Risteys ·

OMOP concept ID	Test name	Measurement unit (harmonized unit)	N people	N records	Missing measurement value	Harmonized value distribution
3021584	s-pappa	mu/l (—)	21607	30639	100.00%	Distribution not available
3021584	s-pappa	— (—)	6685	8234	100.00%	Distribution not available
3021584	retikulosyytit	e9/l (—)	299	532	100.00%	Distribution not available
3021584	s-plasmaproteiinia,raskauteenliittyvä	mu/l (—)	124	125	100.00%	Distribution not available
3021584	plasmaproteiinia,raskauteenliittyvä	mu/l (—)	112	120	100.00%	Distribution not available

LabWAS

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

Delivery

4133

2837

9.37

307.65

1.6

1.2

—

Maternal care for known or suspected abnormality of pelvic organs

3096

7607

3.40

307.65

1.7

1.4

—

Premature rupture of membranes

3446

8236

4.05

307.65

1.6

1.4

—

Other maternal disorders predominantly related to pregnancy

6225

14436

3.14

307.65

1.6

1.5

—

Perineal laceration during delivery

3131

10668

3.69

307.65

1.6

1.5

—

Postpartum haemorrhage

3372

10490

3.48

307.65

1.6

1.5

—

Gestational diabetes (for exclusion)

6111

18199

3.02

307.65

1.6

1.5

—

Delivery, wide proxy

3997

1987

13.57

307.65

1.6

1.1

—

Obstructed labour due to malposition and malpresentation of fetus

2216

8944

2.68

307.65

1.5

1.4

—

Diabetes mellitus in pregnancy

5579

13958

3.34

307.65

1.6

1.5

—

Maternal care related to the fetus and amniotic cavity and possible delivery problems

5405

9201

4.17

307.65

1.6

1.4

—

False labour

4293

8961

3.75

307.65

1.6

1.4

—

Pregnancy, childbirth and the puerperium

3248

1336

15.78

307.65

1.6

1.0

—

Maternal care for other known or suspected fetal problems

4225

8803

4.14

307.65

1.6

1.4

—

Maternal care for known or suspected fetal abnormality and damage

2533

7297

4.16

307.65

1.7

1.4

—

Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium

6702

17336

3.51

307.65

1.6

1.5

—

Long labour

2811

9891

2.95

307.65

1.5

—

Labour and delivery complicated by fetal stress [distress]

4094

10764

3.31

307.65

1.6

1.5

—

Other obstetric conditions, not elsewhere classified

6708

17351

3.47

307.65

1.6

1.5

—

Single delivery by caesarean section

2921

2573

9.13

307.65

1.6

1.1

—

Prolonged pregnancy

2534

7824

3.99

307.65

1.6

1.4

—

Single delivery by forceps and vacuum extractor

2727

2458

10.13

307.65

1.6

1.1

—

Complications of labour and delivery

5888

11956

3.12

307.65

1.6

1.5

—

Supervision of normal pregnancy

3272

1737

14.44

307.65

1.6

1.2

—

Other disorders of amniotic fluid and membranes

1797

6694

3.32

307.65

1.6

1.4

—

Antenatal screening

3559

1758

15.52

307.65

1.5

1.2

—

Supervision of high-risk pregnancy

2893

1663

13.99

307.65

1.7

1.2

—

Contraceptive management

1264

1752

5.31

307.65

1.5

1.3

—

Postpartum care and examination

3142

1666

20.10

307.65

1.7

1.2

—

Persons encountering health services in circumstances related to reproduction

3299

1878

13.13

307.65

1.5

1.3

—

Single spontaneous delivery

3896

2826

8.82

307.65

1.7

1.2

—

Outcome of delivery

3032

1626

17.14

307.65

1.7

1.2

—

Pregnancy examination and test

2954

1694

16.20

307.65

1.6

1.2

—

Procreative management

1806

1620

10.42

307.65

1.6

1.3

—

Other complications of labour and delivery, not elsewhere classified

2675

9430

4.52

307.65

1.6

1.5

—

Maternal care for known or suspected malpresentation of fetus

2536

7309

3.20

307.65

1.6

1.4

—

Female infertility

4018

13473

2.10

303.07

1.5

—

Postpartum hemorraghe, all women as controls

3372

18215

2.16

285.40

1.6

1.5

—

Factors influencing health status and contact with health services

726

690

5.41

270.09

1.5

1.2

—

Female infertility, cervigal, vaginal, other or unspecified origin

3512

12786

2.09

267.33

1.5

—

Maternal care for other conditions predominantly related to pregnancy

2331

11221

2.36

258.39

1.6

1.5

—

Spontaneous abortion

3842

14750

1.92

248.25

1.7

1.4

—

Other abnormal products of conception

3678

14029

1.95

235.12

1.8

1.4

—

Medical treatment for female infertility

2580

13793

2.17

224.92

1.4

1.5

—

Failed induction of labour

975

3672

3.79

210.81

1.5

—

Abnormal findings on antenatal screening of mother

1516

7154

2.87

204.23

1.7

1.5

—

Haemorrhage in early pregnancy

2089

10472

2.12

191.78

1.6

1.5

—

Dental caries 2, only avohilmo

4266

21185

1.65

180.97

1.5

—

Dental caries 2

4247

21153

1.64

174.84

1.5

—

Dental caries 2 and operation codes

4228

21331

1.64

173.18

1.5

—

Multiple delivery

371

762

5.35

172.71

1.5

1.2

—

Pregnancy with abortive outcome

4870

16656

1.61

166.28

1.7

1.4

—

Finngen Rheumatological endpoints

1933

20449

0.52

161.13

1.5

—

Use of hypnotics and sedatives

1223

15269

0.45

160.32

1.4

1.5

—

Complications predominantly related to the puerperium

2441

14154

1.90

158.26

1.6

1.5

—

Antepartum haemorrhage, not elsewhere classified

867

3470

2.94

152.27

1.6

1.4

—

Any operation in hilmo

267

156

9.23

149.44

1.5

1.1

—

Persons encountering health services for specific procedures and health care

1892

21342

0.54

148.19

1.5

—

Benzodiazepine use

1665

22032

0.52

141.77

1.4

1.5

—

Preterm labour and delivery

1225

5765

2.25

139.25

1.6

1.4

—

ILD medications: prednisolone, methylprednisolone, prednisone

2301

22096

0.57

138.81

1.5

—

Cardiovascular diseases (excluding rheumatic etc)

2081

20606

0.56

133.94

1.5

—

Sleep disorders (combined)

1072

14808

0.46

132.49

1.4

1.5

—

Exclusions for E4_PCOS_CONSORTIUM

1815

20025

0.55

129.25

1.4

1.5

—

Other diseases of intestines

2348

22603

0.59

128.26

1.5

—

Statin medication

349

6684

0.29

127.33

1.4

1.5

—

Fall on same level

2629

23603

0.61

125.82

1.5

—

Any event in cancer register

1396

15573

0.52

121.38

1.5

—

Diabetes, insulin treatment (Kela reimbursement)

721

10477

0.41

121.14

1.5

—

Diseases of oesophagus, stomach and duodenum

1554

17190

0.54

120.76

1.5

—

Pre-eclampsia or poor fetal growth

2762

17657

1.69

120.58

1.6

1.5

—

Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium

3276

18889

1.60

119.68

1.5

—

Nerve, nerve root and plexus disorders

1468

16978

0.53

118.79

1.4

1.5

—

Diabetes, insuline treatment (Kela reimbursement), excluding more controls

719

10306

0.42

117.28

1.5

—

ILD medications

2689

23176

0.62

115.84

1.5

—

Inflammatory bowel disease treatment related agents

2570

23114

0.62

115.23

1.5

—

Codeine or tramadol medication

2596

22664

0.62

113.94

1.5

—

Pregnancy hypertension

3118

18594

1.60

113.18

1.5

—

Oral corticosteroids

1961

19909

0.58

112.77

1.5

—

Tramadol

775

10986

0.44

108.36

1.4

1.5

—

Influenza and pneumonia

2089

22412

0.60

108.28

1.5

—

Antihypertensive medication - note that there are other indications

2742

22865

0.63

106.96

1.4

1.5

—

Codeine

2555

21786

0.63

104.96

1.5

—

Postpartum hemorraghe, parous women as controls

3372

20711

1.59

101.42

1.6

1.5

—

Abnormalities of breathing

2288

21334

0.62

99.64

1.5

—

Other intervertebral disc disorders

1069

12529

0.51

98.38

1.5

—

Sleep apnoea, including avohilmo

605

9179

0.42

97.98

1.4

1.5

—

Placenta praevia

461

1682

3.30

97.94

1.6

1.4

—

Pain in throat and chest

1477

15662

0.56

96.81

1.5

—

Other heart diseases, wide

1567

16521

0.58

94.96

1.5

—

Diabetes mellitus

1718

17019

0.59

94.19

1.5

—

Female infertility, associated with anovulation

1353

8003

2.07

92.33

1.5

—

First line medication for Crohn's disease

2846

22947

0.66

91.30

1.5

—

Polyhydramnios

504

2009

3.05

91.26

1.6

1.4

—

Poor fetal growth

1644

10198

1.87

89.81

1.6

1.5

—

Other obstetric trauma

558

2352

2.84

89.49

1.6

1.4

—

Diabetes, varying definitions

1678

16516

0.60

89.07

1.5

—

Autoimmune diseases excluding thyroid diseases, strict definition

2412

20396

0.65

88.54

1.5

—

Multiple gestation

663

2968

2.47

88.41

1.5

1.4

—

Autoimmune diseases excluding thyroid diseases

2461

20609

0.65

87.71

1.5

—

Twin gestation

645

2888

2.47

86.03

1.5

1.4

—

Malignant neoplasm, wide definition for exclusion, excluding all cancers (controls excluding all cancers)

783

9394

0.49

85.62

1.5

—

Malignant neoplasm, wide definition for exclusion

783

9394

0.49

85.61

1.5

—

Malignant neoplasm, excluding all cancers (controls excluding all cancers)

783

9385

0.49

85.35

1.5

—

1844

18284

0.62

83.38

1.5

—

COPD/asthma/ILD related pneumonia or pneumonia derived septicaemia

1844

18284

0.62

83.38

1.5

—

Metabolic disorders

715

9171

0.48

82.35

1.4

1.5

—

All pneumoniae

1836

19965

0.62

81.83

1.5

—

Hypertensive diseases

481

6472

0.41

80.54

1.5

—

Pneumonias (Asthma/COPD co-morbidities)

1816

19771

0.62

80.01

1.5

—

Gestational [pregnancy-induced] hypertension

2188

14554

1.61

79.81

1.5

—

Hypertension

481

6445

0.42

79.74

1.5

—

Hypertensive diseases (excluding secondary)

468

6462

0.41

79.12

1.5

—

Artrosis, including avohilmo

565

6868

0.45

78.51

1.4

1.5

—

Excessive vomiting in pregnancy

750

3754

2.27

77.65

1.5

—

Other puerperal infections

1112

6534

2.05

76.66

1.6

1.5

—

Diabetes medication

1740

16624

0.63

75.52

1.5

—

Malignant neoplasm

648

7928

0.48

74.17

1.5

—

Liveborn infants according to place of birth

11.97

73.15

1.8

1.2

—

Symptoms and signs involving cognition, perception, emotional state and behaviour

1496

16856

0.61

72.72

1.5

—

Other specific joint derangements/joint disorders

2192

21679

0.66

72.35

1.5

—

Pneumonia (excl. viral and due to other infectious organisms not elsewhere classified)

1683

18472

0.63

72.12

1.5

—

Tonsillectomy and adenotomy

3970

20618

1.39

70.25

1.5

—

Parodontitis or/and operation codes

904

9743

0.54

69.84

1.5

—

Other antidepressants

2544

19064

0.68

69.35

1.4

1.5

—

Sleep apnoea

458

7040

0.44

68.57

1.4

1.5

—

Hypertension, essential

419

5547

0.43

65.98

1.5

—

Retained placenta and membranes, without haemorrhage

531

2456

2.30

63.59

1.6

1.5

—

Other assisted single delivery

133

276

5.80

63.23

1.5

1.2

—

Pain in limb

1803

19456

0.66

62.88

1.5

—

Asthma/COPD (KELA code 203)

2250

22735

0.69

62.84

1.5

—

Kela-code for severe mental illness

462

9907

0.45

62.75

1.4

1.5

—

Abnormalities of forces of labour

515

2381

2.31

62.12

1.6

1.4

—

Polyarthropathies

1056

11755

0.59

60.24

1.5

—

Other soft tissue disorders, not elsewhere classified

2537

21870

0.70

60.10

1.5

—

Special screening examination for infectious and parasitic diseases

2287

12018

1.49

59.73

1.5

—

Unspecified mental disorder

670

12445

0.52

59.07

1.4

1.5

—

Shoulder lesions

490

6282

0.47

58.80

1.4

1.5

—

Personality disorders, excluding more controls

744

13232

0.54

58.71

1.4

1.5

—

Intracranial trauma

1438

16471

0.64

57.75

1.5

—

Infections of genitourinary tract in pregnancy

840

4814

1.93

57.48

1.5

—

Type 2 diabetes

1384

12806

0.63

57.43

1.5

—

Arthrosis

365

4649

0.43

57.14

1.5

—

Disorders of adult personality and behaviour

773

13493

0.55

56.73

1.4

1.5

—

Schizophrenia or delusion, excluding more controls

409

8729

0.45

56.29

1.5

—

Pneumonia, organism unspecified

1412

15667

0.64

55.71

1.5

—

Disorders of gallbladder, biliary tract and pancreas

1178

12161

0.62

55.71

1.5

—

Labour and delivery complicated by umbilical cord complications

342

1413

2.71

55.10

1.6

1.4

—

Cardiac arrhythmias

1239

12872

0.62

54.93

1.5

—

Polycystic ovarian syndrome, consortium definition

2829

22971

0.72

54.80

1.5

—

Menorrhagia

861

8133

0.57

54.49

1.5

—

Other obstructed labour

410

1841

2.41

53.69

1.6

1.4

—

Lower back pain or/and sciatica

2419

23148

0.71

53.67

1.4

1.5

—

Injuries to the head

2665

23583

0.73

53.17

1.5

—

Opioids

3218

22341

0.74

52.30

1.5

—

Pre-eclampsia

1295

8544

1.60

48.55

1.6

1.5

—

Condition for Implicit Sepsis (Organ dysfunction codes)

1069

12260

0.63

48.08

1.5

—

Pre-eclampsia or eclampsia

1315

8723

1.58

47.79

1.6

1.5

—

Polycystic ovarian syndrome, broad definition

1565

11073

1.60

47.61

1.5

—

Schizophrenia or delusion

409

8249

0.48

46.74

1.5

—

Other bacterial diseases

1019

11191

0.62

46.71

1.5

—

Schizophrenia, schizotypal and delusional disorders

409

8247

0.48

46.70

1.5

—

Personality disorders

744

12403

0.58

45.77

1.4

1.5

—

Leiomyoma of uterus

553

5741

0.53

45.02

1.4

1.5

—

Injuries to the knee and lower leg

3107

23139

0.76

44.99

1.5

—

Leiomyoma of uterus

557

5797

0.54

43.93

1.4

1.5

—

Specific personality disorders

667

11189

0.57

42.37

1.4

1.5

—

Substance abuse, excluding more controls

914

12611

0.62

42.01

1.4

1.5

—

Cardiovascular diseases

3198

22236

0.77

41.22

1.5

—

Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified

987

9993

0.64

40.84

1.5

—

Acute upper respiratory infections

3945

19645

1.27

40.79

1.5

—

Any reimbursement code in KELA

3024

19452

0.76

40.21

1.5

—

Spondylopathies

573

6163

0.56

40.13

1.5

—

Complications of surgical and medical care, not elsewhere classified

1838

18093

0.72

39.50

1.5

—

Other and unspecified nonorganic psychotic disorders

315

6481

0.47

39.03

1.5

—

Other disorders of ear

978

9967

0.65

37.60

1.5

—

Complications of the puerperium, not elsewhere classified

428

2306

2.16

37.45

1.5

—

Dental caries 2 and operation codes, only avohilmo

3089

14990

1.30

37.27

1.5

—

Chronic lower respiratory diseases

3359

22881

0.78

37.07

1.5

—

Other heart diseases

815

8479

0.62

36.49

1.5

—

Benign neoplasms

3212

22624

0.78

36.44

1.5

—

Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified (FINNGEN)

658

6903

0.59

36.17

1.5

—

Type 2 diabetes, definitions combined, including avohilmo

1236

10628

0.68

36.11

1.5

—

Migraine, single triptan purchase ok & required. ICD-code if available is included

3779

20606

1.26

36.05

1.5

—

Triptan medication for migraine, single purchase ok

3779

20606

1.26

36.05

1.5

—

Any event in hilmo or specialist outpatient

11.65

35.84

1.5

1.0

—

Habitual aborter

311

1558

2.56

35.79

2.0

1.5

—

Cholelithiasis, broad definition with cholecystitis

1058

10785

0.67

35.63

1.5

—

Low back pain

1938

19939

0.74

35.55

1.4

1.5

—

Infections of breast associated with childbirth

427

2365

2.13

35.11

1.6

1.5

—

Cystitis

4049

20110

1.25

34.96

1.5

—

Other disorders of breast and lactation associated with childbirth

317

1684

2.65

33.66

1.7

1.5

—

Schizophrenia

2642

0.24

33.58

1.4

1.5

—

Endometriosis diagnosis and infertility diagnosis occurring together

752

4825

1.67

32.85

1.4

1.5

—

Hernia

1135

11128

0.69

32.73

1.5

—

Anaemias

990

9627

0.66

32.68

1.6

1.5

—

Ectopic pregnancy

784

5034

1.62

32.56

1.6

1.4

—

Other (not insulin) diabetes medications

1261

10772

0.70

32.14

1.6

1.5

—

Type 2 diabetes, wide definition

290

3822

0.49

31.69

1.5

—

Oxicams

294

3346

0.49

31.55

1.4

1.5

—

Dermatitis and eczema

4047

21797

1.23

31.32

1.5

—

Emotionally unstable personality disorder

476

7926

0.56

30.96

1.4

1.5

—

Dorsalgia

3181

21372

0.80

30.93

1.5

—

Intrahepatic Cholestasis of Pregnancy (ICP)

638

4039

1.74

30.72

1.6

1.5

—

Constipation

927

9827

0.67

30.57

1.4

1.5

—

Any mental disorder

2978

18642

0.79

30.46

1.5

—

Type 2 diabetes, definitions combined

1208

10193

0.70

30.40

1.5

—

Type 2 diabetes, strict (exclude DM1)

1207

10186

0.70

30.32

1.5

—

Parodontitis or operation codes

957

10334

0.68

30.09

1.5

—

Bleeding

597

7033

0.61

30.01

1.5

—

Benign neoplasms

3158

22058

0.80

29.98

1.5

—

Psychiatric diseases

2982

18630

0.79

29.97

1.5

—

Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8

639

4044

1.70

29.96

1.6

1.5

—

Endometriosis

1447

11668

0.72

29.91

1.4

1.5

—

Hyperkinetic disorders, excluding more controls

480

7655

0.57

29.87

1.4

1.5

—

Parodontitis

957

10325

0.68

29.83

1.5

—

Atopic dermatitis

3131

21670

1.26

29.46

1.5

—

Lumbar disc prolapse

797

9557

0.66

29.43

1.5

—

Renal tubulo-interstitial diseases

1843

18526

0.75

29.36

1.5

—

Personal history of other diseases and conditions

811

5403

1.59

29.24

1.8

1.5

—

Cholelithiasis

1041

10476

0.69

29.07

1.5

—

Persons with potential health hazards related to family and personal history and certain conditions influencing health status

2049

18008

0.76

28.96

1.6

1.5

—

Chronic periodontitis, including avohilmo

955

10275

0.68

28.77

1.5

—

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

1772

16708

0.75

28.56

1.6

1.5

—

Bipolar affective disorders

520

8404

0.60

28.43

1.4

1.5

—

Exposure to unspecified factor

2406

23562

0.78

28.37

1.5

—

Persons encountering health services for other counselling and medical advice, not elsewhere classified

4010

18911

1.22

28.30

1.5

—

Behavioural and emotional disorders with onset usually occurring in childhood and adolescence

1208

14845

0.71

27.27

1.4

1.5

—

Inflammatory disorders of breast

582

3720

1.73

27.25

1.7

1.5

—

Dyspnoea

1488

15235

0.74

27.10

1.5

—

Placental disorders

110

383

3.73

26.72

1.7

1.4

—

Depression medications

1911

12374

0.76

26.70

1.5

—

Noninflammatory disorders of female genital tract

3577

14941

1.24

25.65

1.5

—

Pre-existing hypertension complicating pregnancy, childbirth and the puerperium

482

2949

1.75

25.50

1.5

—

Injuries to the shoulder and upper arm

1095

12713

0.72

25.27

1.5

—

Ovarian cyst

1794

13285

0.76

24.60

1.5

—

Malignant neoplasm of breast, excluding all cancers (controls excluding all cancers)

183

2584

0.46

24.56

1.3

1.5

—

Malignant neoplasm of breast, HER2-negative, excluding all cancers (controls excluding all cancers)

183

2583

0.46

24.53

1.3

1.5

—

Other joint disorders

3392

21736

0.82

24.47

1.5

—

Implicit Sepsis

805

9096

0.68

24.47

1.5

—

Disorders of lipoprotein metabolism and other lipidaemias

233

2920

0.50

24.43

1.5

—

Chronic diseases of tonsils and adenoids

3479

18291

1.22

24.34

1.5

—

Selective serotonin reuptake inhibitors

2982

19068

0.82

23.48

1.5

—

Suicide or other Intentional self-harm

506

7913

0.62

23.44

1.4

1.5

—

Disorders of choroid and retina

532

6073

0.63

23.29

1.5

—

Disorders of eyelid, lacrimal system and orbit

1256

13197

0.74

23.29

1.4

1.5

—

Heart failure, not strict

171

2561

0.46

23.22

1.5

—

Persistent mood disorders

276

5022

0.54

23.11

1.4

1.5

—

Concussion

1374

15627

0.75

22.93

1.5

—

Premature separation of placenta [abruptio placentae]

144

605

2.64

22.66

1.8

1.4

—

Biguanides

1236

10222

0.74

22.55

1.6

1.5

—

Acute upper respiratory infections of multiple and unspecified sites

3145

19584

1.22

22.45

1.5

—

Gonarthrosis

188

2243

0.48

22.29

1.4

1.5

—

Disturbance of activity and attention

462

7041

0.61

22.14

1.4

1.5

—

Hyperkinetic disorders

480

7245

0.62

21.85

1.4

1.5

—

867

10844

0.71

21.39

1.4

1.5

—

Hypothyroidism, drug reimbursement

382

4455

0.60

21.03

1.5

—

Mental and behavioural disorders due to psychoactive substance use

957

12356

0.72

20.94

1.4

1.5

—

Phobic anxiety disorders

513

7709

0.64

20.90

1.4

1.5

—

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

429

6744

0.61

20.90

1.4

1.5

—

Malignant neoplasm of breast

163

2489

0.47

20.80

1.3

1.5

—

Venous complications and haemorrhoids in pregnancy

177

861

2.41

20.78

1.6

1.5

—

Parodontitis and operation codes

920

9876

0.72

20.78

1.5

—

Dizziness and giddiness

1099

11968

0.74

20.75

1.5

—

ILD medications: immunosuppressive drugs

1147

14607

0.74

20.58

1.5

—

Conductive and sensorineural hearing loss

460

5013

0.63

20.45

1.5

—

Care involving use of rehabilitation procedures

770

10310

0.70

20.17

1.5

—

Diseases of middle ear and mastoid

3252

22521

1.20

20.03

1.5

—

Other arrhythmias

959

9999

0.73

19.96

1.5

—

Gonarthrosis [arthrosis of knee](FG)

194

2249

0.51

19.62

1.5

—

Malaise and fatigue

680

8124

0.69

19.52

1.5

—

Postpartum haemorrhage due to anatomy

1751

14471

1.34

19.21

1.6

1.5

—

Disorders of psychological development

421

5987

0.62

18.88

1.5

—

Poisoning by drugs, medicaments and biological substances

648

9217

0.69

18.84

1.4

1.5

—

All anxiety disorders

3152

21492

1.20

18.79

1.5

—

Substance abuse

914

11830

0.73

18.78

1.4

1.5

—

Medical abortion

3549

16441

1.19

18.76

1.5

1.4

—

Ovarian hyperstimulation (induction)

215

1187

2.20

18.66

1.5

—

Complications associated with artificial fertilization

229

1288

2.14

18.65

1.4

1.5

—

Gender identity disorders

899

0.10

18.43

1.0

1.5

—

Schizoaffective disorder

1976

0.35

18.36

1.3

1.5

—

Other diseases of urinary system

4144

20138

1.17

17.98

1.5

—

Poisoning by medicine

597

8524

0.68

17.83

1.4

1.5

—

Hard cardiovascular diseases

168

2145

0.50

17.72

1.6

1.5

—

Social phobias

300

4864

0.58

17.57

1.4

1.5

—

Malignant neoplasm of breast, HER2-negative

150

2254

0.49

17.44

1.3

1.5

—

Other degenerative diseases of the nervous system

214

2956

0.54

17.44

1.4

1.5

—

Excessive, frequent and irregular menstruation

2163

14533

0.81

17.40

1.5

—

Sensorineural hearing loss

325

3731

0.61

17.39

1.6

1.5

—

Rotator cuff syndrome

257

3317

0.57

17.38

1.4

1.5

—

816

10189

0.73

17.18

1.4

1.5

—

Autoimmune diseases related-to ILD

1995

21357

0.81

17.15

1.5

—

Disorders of lens

126

1721

0.46

17.02

1.8

1.5

—

Other neurological diseases

596

6869

0.69

16.94

1.5

—

Polyp of the female genital tract

557

4707

0.68

16.93

1.4

1.5

—

Coxibs

902

6429

0.73

16.65

1.4

1.6

—

Bronchitis

3898

22147

1.16

16.58

1.5

—

Disorders of skin appendages

1301

16450

0.78

16.54

1.4

1.5

—

Other disorders of urethra and urinary system

1733

15968

0.80

16.36

1.5

—

Alcohol use disorder, Swedish definition

648

8405

0.71

16.19

1.4

1.5

—

Maternal care for cervical incompetence

253

1484

1.85

16.17

1.7

1.5

—

Other specified and unspecified personality disorders

170

3148

0.52

15.76

1.5

—

Hypothyroidism, strict autoimmune, 3 medication purchases required

2672

21455

0.84

15.72

1.5

—

Asthma, unspecified (mode), excluding more controls

1008

10317

0.76

15.70

1.5

—

Anxiety (asthma-related co-morbidities)

3001

20319

1.18

15.18

1.5

—

Artificial joint operation, meniscal resection

495

4802

0.68

15.17

1.5

—

Puerperal sepsis

355

2270

1.60

15.07

1.6

1.5

—

Wide developmental disorders, excluding more controls

1371

0.31

15.00

1.5

1.6

—

Meniscus derangement

349

3715

0.64

14.91

1.5

—

Asthma, unspecified (mode)

1008

10333

0.77

14.80

1.5

—

Other symptoms and signs involving the nervous and musculoskeletal systems

713

9606

0.73

14.47

1.4

1.5

—

Symptoms and signs involving the nervous and musculoskeletal systems

911

11868

0.76

14.46

1.4

1.5

—

Other retinal disorders

403

4837

0.67

14.38

1.5

—

Neurotic, stress-related and somatoform disorders

3484

21567

1.16

14.17

1.5

—

Disorders of thyroid, IBD co-morbidities

727

7080

0.73

14.16

1.5

—

Autism spe, excluding more controls

1120

0.27

14.04

1.5

—

Cerebrovascular diseases

216

2644

0.58

13.76

1.5

—

Anxiety disorders

3485

21565

1.16

13.65

1.5

—

Other nutritional deficiencies

2597

21768

1.18

13.65

1.5

—

Insulin, fast-acting (human)

276

4358

0.62

13.63

1.4

1.5

—

Wide developmental disorders

1319

0.33

13.53

1.5

—

Persons with potential health hazards related to communicable diseases

2495

21255

1.19

13.50

1.5

—

Generalized anxiety disorder

724

9508

0.74

13.40

1.4

1.5

—

Contact with and exposure to communicable diseases

2338

19953

1.19

13.32

1.5

—

Mental and behavioural disorders due to alcohol

717

9288

0.74

13.25

1.5

—

Autism

1109

0.29

13.04

1.5

—

Pure hypercholesterolaemia

188

2204

0.57

13.01

1.6

1.5

—

Mixed and other personality disorders

141

2591

0.52

12.81

1.3

1.5

—

Asthma (diagnoses ohter than nonallergic)

2274

22773

0.85

12.80

1.5

—

STROKE

237

2693

0.61

12.78

1.5

—

Autism spe

1064

0.29

12.73

1.5

—

Neurological diseases

3542

20296

0.87

12.68

1.5

—

Other diseases of hard tissues of teeth

1990

12482

1.20

12.59

1.5

—

Other reaction to severe stress, and adjustment disorders

1415

17164

0.81

12.54

1.4

1.5

—

Inguinal hernia

483

4596

0.70

12.51

1.6

1.5

—

Cerebrovascular diseases (FINNGEN)

164

2095

0.56

12.47

1.5

—

Carpal tunnel syndrome

592

7258

0.73

12.43

1.4

1.5

—

Fenamates

455

4326

0.69

12.36

1.4

1.5

—

Female infertility, tubal origin

252

1592

1.66

11.82

1.4

1.5

—

Injuries to the elbow and forearm

1627

17575

0.83

11.80

1.5

—

Iron deficiency

226

1435

1.80

11.75

1.7

1.5

—

Postpartum haemorrhage due to retained placenta

1379

11538

1.26

11.73

1.6

1.5

—

Mental and behavioural disorders due to alcohol, excluding acute intoxication

485

6711

0.72

11.72

1.4

1.5

—

Sub-endpoint used in defining T1D endpoints

503

6797

0.72

11.72

1.5

—

Irregular menses

2374

22231

0.85

11.70

1.5

—

Acne

556

7390

0.72

11.70

1.4

1.5

—

Diseases of arteries, arterioles and capillaries

263

3064

0.64

11.62

1.4

1.5

—

Acute and transient psychotic disorders

114

2187

0.51

11.62

1.4

1.5

—

Type 1 diabetes, wide definition

449

6253

0.71

11.60

1.5

—

Chronic lymphocytic leukaemia and small lyphocytis leukaemia, excluding all cancers (controls excluding all cancers)

23.21

11.59

3.6

1.3

—

Chronic lymphocytic leukaemia, helper endpoint

23.21

11.59

3.6

1.3

—

Insulin, intermediate and long-acting

542

7217

0.73

11.49

1.5

—

Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis

2830

20194

1.16

11.47

1.5

—

KRA_PSY_EATING, excluding more controls

733

9234

0.75

11.34

1.5

—

Disorders of synovium and tendon

1094

12192

0.80

11.31

1.5

—

Type 1 diabetes, wide definition, subgroup 1

445

6151

0.71

11.04

1.5

—

Dislocation, sprain and strain of joints and ligaments of knee

1613

17797

0.83

11.03

1.5

—

Alcohol dependence

118

2219

0.53

11.03

1.3

1.6

—

Injuries to the wrist and hand

2832

23410

0.87

11.01

1.5

—

Behavioural syndromes associated with physiological disturbances and physical factors

1406

16801

0.82

10.97

1.5

—

Nonorganic sleeping disorders, excluding more controls

557

7402

0.74

10.87

1.4

1.5

—

Follow-up examination after treatment for conditions other than malignant neoplasms

1487

11662

0.83

10.83

1.6

1.5

—

Chronic lymphocytic leukaemia

18.05

10.74

3.6

2.3

—

Other and unspecified mood [affective] disorders

278

4102

0.65

10.74

1.5

—

Other arthrosis

152

1902

0.57

10.74

1.4

1.5

—

Mental and behavioural disorders due to multiple drug use and use of multiple drugs and use of other psychoactive substances

118

2162

0.53

10.68

1.3

1.5

—

Alcohol use disorder, ICD-based

459

6313

0.72

10.68

1.4

1.5

—

Type 1 diabetes

501

6761

0.73

10.62

1.5

—

Gastro-oesophageal reflux disease

814

9156

0.78

10.47

1.5

—

Abrasion of teeth

470

4721

0.72

10.44

1.5

—

General examination and investigation of persons without complaint and reported diagnosis

1953

12161

0.85

10.38

1.4

1.5

—

Arthropathies

3819

21736

0.89

10.37

1.5

—

Family history of certain disabilities and chronic diseases leading to disablement

322

2230

1.53

10.32

1.9

1.5

—

Symptoms and signs involving the urinary system

903

8755

0.79

10.31

1.6

1.5

—

Speech and linguistic disorders, excluding more controls

331

4428

0.68

10.26

1.5

1.6

—

L04AX Other immunosuppressants

921

11464

0.80

10.18

1.5

—

Insulin, fast-acting or short human

513

6868

0.74

10.13

1.5

—

Episodal and paroxysmal disorders

3829

21919

0.89

10.11

1.5

—

Oxycodone

1848

0.52

10.06

1.5

—

Soft tissue disorders

3775

21905

0.89

10.03

1.5

—

Depression or dysthymia

1830

12002

0.85

10.02

1.5

1.6

—

Infections, IBD-co-morbidities

231

2597

0.64

9.99

1.5

—

Genitourinary diseases

2288

9909

1.17

9.96

1.5

—

Insulin, fast-acting

513

6840

0.74

9.88

1.5

—

Multiple myeloma, Monoclonal gammopathy of undetermined significance (MGUS), excluding all cancers (controls excluding all cancers)

3.73

9.86

2.2

1.4

—

Exposure to other specified factors

1922

20907

0.86

9.82

1.5

—

Post-traumatic stress disorder

461

6114

0.72

9.74

1.5

—

Falls/tendency to fall

3884

21653

0.89

9.64

1.5

—

Dissociative [conversion] disorders

130

2208

0.55

9.63

1.4

1.5

—

Second line medication for Crohn's disease

997

12228

0.81

9.62

1.5

—

Non-selective monoamine reuptake inhibitors

226

3368

0.65

9.59

1.4

1.5

—

Gonarthrosis,primary

155

1650

0.59

9.59

1.4

1.5

—

Ischemic heart diseases

155

1642

0.59

9.57

1.8

1.5

—

Insulin medication

791

8500

0.79

9.37

1.5

—

Epilepsy

471

6291

0.74

9.36

1.4

1.5

—

Mental retardation, excluding more controls

842

0.31

9.35

1.4

1.6

—

Neoplasms

3633

21680

0.89

9.33

1.5

—

Other dorsopathies, not elsewhere classified

3638

21381

0.89

9.27

1.5

—

Symptoms and signs involving the digestive system and abdomen

3543

15889

1.12

8.98

1.5

—

Oter anti-inflammatory and antirheumatic agents, non-steroids

949

0.51

8.89

1.3

1.5

—

Substance use, excluding alcohol

365

5025

0.72

8.87

1.4

1.5

—

Organic, including symptomatic, mental disorders

1140

0.50

8.84

1.6

1.5

—

Childhood allergy (age < 16)

1506

14339

0.83

8.79

1.5

—

Abdominal and pelvic pain

3526

15888

1.12

8.72

1.5

—

Agoraphobia

101

1781

0.53

8.64

1.5

—

Acne vulgaris

435

5714

0.73

8.54

1.4

1.5

—

Obsessive-compulsive disorder

304

4215

0.69

8.52

1.4

1.5

—

Use of disulfiram, acamprosate or naltrexone

733

0.30

8.43

1.1

1.5

—

Mental and behavioural disorders due to opioids

1372

0.48

8.42

1.3

1.5

—

Sciatica+with lumbago

807

9472

0.80

8.41

1.4

1.5

—

Panic disorder

745

9178

0.79

8.29

1.4

1.5

—

Mental retardation, wide definition

806

0.34

8.29

1.4

1.5

—

L04AA Selective immunosuppressants

228

3371

0.67

8.24

1.4

1.5

—

Stroke, including SAH

133

1650

0.59

8.13

1.5

—

Complications of procedures, not elsewhere classified

1608

16110

0.86

8.12

1.5

—

Supplementary factors related to causes of morbidity and mortality classified elsewhere

573

7316

0.77

8.10

1.4

1.5

—

Mental retardation

794

0.34

8.07

1.4

1.5

—

Diabetic nephropathy, excluding more controls

1154

0.49

8.04

1.3

1.5

—

Major coronary heart disease event

934

0.50

7.85

1.8

1.6

—

Osteopathies and chondropathies

694

8195

0.80

7.74

1.4

1.5

—

Intentional self-harm by sharp object

1314

0.49

7.72

1.3

1.5

—

Convulsions, not elsewhere classified

544

6852

0.77

7.71

1.5

—

Malignant neoplasm of breast, ER-positive, excluding all cancers (controls excluding all cancers)

1207

0.52

7.68

1.3

1.4

—

Headache

2691

20117

1.13

7.65

1.5

—

Other surgical follow-up care

153

959

1.68

7.64

1.7

1.5

—

Intracranial injury

1277

14445

0.85

7.49

1.5

—

Any mental disorder, or suicide (or attempt), or psychic disorders complicating pregnancy, partum or puerperium or nerve system disorders

1650

14398

1.16

7.45

1.5

—

Mood disorders, excluding more controls

2745

18632

0.89

7.39

1.4

1.5

—

Dental caries

411

5358

0.75

7.37

1.5

—

Hydatidiform mole

474

2.00

7.37

1.7

1.4

—

Unspecified maternal hypertension

107

632

1.92

7.34

1.6

1.5

—

Neurological diseases, wide definition

2029

11540

0.87

7.30

1.5

—

Stroke, excluding SAH

115

1438

0.59

7.21

1.5

—

Systemic connective tissue disorders

444

5760

0.76

7.10

1.5

—

Type of accident

510

6491

0.78

7.09

1.4

1.5

—

Obesity

2341

20698

1.13

7.09

1.5

—

Other eating disorders

364

4724

0.73

7.09

1.5

—

Other systemic involvement of connective tissue (FG)

343

4575

0.74

7.08

1.5

—

Injuries to the hip and thigh

439

5225

0.76

7.05

1.6

1.5

—

Nonorganic sleeping disorders

557

6985

0.78

7.05

1.4

1.5

—

Obesity and other hyperalimentation

2344

20723

1.13

7.03

1.5

—

Monoclonal gammopathy of undetermined significance (MGUS), excluding all cancers (controls excluding all cancers)

4.22

7.02

2.6

1.4

—

Sleep disorders

597

7430

0.79

7.01

1.4

1.5

—

Other systemic involvement of connective tissue

347

4645

0.74

7.01

1.5

—

Mental disorders, not otherwise specified

244

3404

0.70

6.86

1.5

—

Open wound of wrist and hand

974

11439

0.84

6.79

1.5

—

Schizotypal disorder

548

0.28

6.79

1.3

1.5

—

Senile cataract

793

0.52

6.74

2.1

1.5

—

Speech and linguistic disorders

331

4209

0.73

6.73

1.5

—

Fibromyalgia

160

2415

0.65

6.72

1.3

1.5

—

Focal epilepsy

274

3767

0.72

6.68

1.4

1.5

—

Acetic acid derivatives and related substances

1031

6356

0.84

6.63

1.5

1.6

—

Erysipelas

256

3258

0.71

6.60

1.5

—

Transplanted organ and tissue status

813

0.41

6.54

1.6

1.5

—

Focal epilepsy, strict definition

217

3092

0.69

6.54

1.4

1.5

—

Type 1 diabetes, strict definition

287

3858

0.72

6.52

1.4

1.5

—

Hallux valgus (acquired)

223

2304

0.70

6.51

1.4

1.5

—

Focal epilepsy, mode (most common among epilepsy diagnosis)

222

3136

0.70

6.39

1.4

1.5

—

Other diseases of pleura

114

1635

0.62

6.25

1.5

—

Type1 diabetes, definitions combined, early onset

265

3562

0.72

6.20

1.5

—

Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium

155

1040

1.61

6.15

1.6

1.5

—

Cervicobrachial syndrome

262

3581

0.72

6.14

1.3

1.5

—

Bacterial pneumoniae

460

5164

0.78

6.11

1.6

1.5

—

Multiple myeloma and malignant plasma cell neoplasms

3.78

6.09

1.7

1.4

—

Multiple myeloma, excluding all cancers (controls excluding all cancers)

3.78

6.09

1.7

1.4

—

Ischaemic Stroke, excluding all haemorrhages

1230

0.59

6.09

1.5

—

Disorders of ocular muscles, binocular movement, accommodation and refraction

1487

16773

0.87

6.08

1.5

—

Nephropathy related operations

774

0.42

6.06

1.8

1.5

—

Abnormal findings on diagnostic imaging and in function studies, without diagnosis

418

4963

0.78

6.02

1.5

—

External causes of morbidity and mortality

2784

15379

0.90

5.99

1.5

—

Intestinal infectious diseases

3233

23002

1.10

5.98

1.5

—

Multiple myeloma and malignant plasma cell neoplasms

3.70

5.92

1.7

1.6

—

Type 1 diabetes, strict definition, subgroup 1

286

3786

0.73

5.90

1.4

1.5

—

Care involving dialysis

501

0.30

5.90

1.5

1.6

—

Coronary revascularization (ANGIO or CABG)

569

0.44

5.89

1.3

1.6

—

Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified

121

760

1.63

5.88

1.4

1.5

—

Anankastic personality disorder

1357

0.57

5.83

1.4

1.5

—

Dialysis, with operation codes

775

0.43

5.82

1.9

1.5

—

L02BG Aromatase inhibitors

250

1810

1.39

5.81

1.5

—

Other enthesopathies

307

4065

0.75

5.79

1.4

1.5

—

Hirsutism in women

1273

0.55

5.78

1.4

1.5

—

Viral hepatitis, IBD co-morbidity

109

1723

0.62

5.78

1.4

1.5

—

Syncope and collapse

728

7741

0.83

5.76

1.5

—

Dental pulpitis 3, only avohilmo

1571

10229

1.16

5.75

1.6

1.5

—

Fever of other and unknown origin

1232

13127

0.86

5.75

1.5

—

Mental and behavioural disorders due to sedatives or hypnotics

1366

0.57

5.74

1.3

1.5

—

Hypertrophy of breast

315

4128

0.75

5.68

1.4

1.5

—

Asthma, including avohilmo

3588

22650

0.92

5.67

1.5

—

Abnormal findings in secretions and smears from cervix uteri vagina vulva

2792

20031

1.11

5.66

1.4

1.5

—

Psychotic depression

138

2061

0.65

5.65

1.4

1.6

—

Abnormal findings on examination of blood, without diagnosis

344

4186

0.77

5.63

1.5

—

Eating disorders

746

8779

0.82

5.61

1.5

—

Obstructed labour due to maternal pelvic abnormality

163

1100

1.49

5.60

1.6

1.4

—

Type 1 diabetes, definitions combined

320

4147

0.75

5.59

1.5

—

Hypertrichosis

1376

0.57

5.57

1.4

1.5

—

Unspecified abortion

515

1.74

5.57

1.7

1.4

—

Eating disorder

733

8600

0.82

5.55

1.5

—

Type 1 diabetes, strict (exclude DM2)

320

4142

0.75

5.55

1.5

—

Coxarthrosis

924

0.58

5.52

1.6

1.5

—

Somatoform disorder

347

4469

0.77

5.51

1.5

—

Hypertrophy of breast in women and men

317

4136

0.76

5.50

1.4

1.5

—

Other menopausal disorders

110

1009

0.63

5.49

1.3

1.4

—

Asthma, hospital admissions , main diagnosis only

2321

22939

0.90

5.49

1.5

—

Inflammatory disease of uterus

873

7463

1.20

5.49

1.6

1.5

—

Anxious personality disorder

812

0.46

5.48

1.2

1.5

—

Other cataract

1127

0.60

5.47

1.6

1.5

—

L01XX Other antineoplastic agents

3.48

5.45

2.5

1.6

—

Migraine without aura

1047

12051

0.85

5.45

1.5

—

Diseases of liver

220

3031

0.72

5.42

1.5

—

Emergency coronary revascularization (for ACS)

605

0.47

5.40

1.3

1.6

—

Cholecystectomy

876

9095

0.85

5.38

1.5

—

Congenital malformations and deformations of the musculoskeletal system

272

3565

0.74

5.35

1.5

—

Bacterial pneumonia, not elsewhere classified

427

4743

0.79

5.27

1.6

1.5

—

Coronary angioplasty

533

0.43

5.26

1.3

1.5

—

Other and unspecified coagulation defects

186

1318

1.46

5.26

1.5

—

Dislocation, sprain and strain of joints and ligaments at wrist and hand level

760

8977

0.84

5.25

1.5

—

Implicit bacterial Sepsis

146

1970

0.68

5.22

1.5

—

Secondary uncertain malignant neoplasm, excluding all cancers (controls excluding all cancers)

114

1549

0.64

5.19

1.3

1.5

—

Diverticular disease of intestine

161

1553

0.69

5.19

1.4

1.5

—

Hypermobility syndrome

198

2707

0.71

5.19

1.4

1.5

—

Acute tubulo-interstitial nephritis

1529

15253

0.88

5.16

1.5

—

Open wound of forearm

141

2065

0.67

5.15

1.4

1.5

—

Fentanyl

318

0.28

5.15

1.2

1.6

—

Kidney transplant status

477

0.33

5.15

1.3

1.5

—

Mild mental retardation

543

0.37

5.13

1.5

—

Glucagon-like peptide-1 (GLP-1) analogues

1062

0.59

5.12

1.4

1.5

—

Other disorders of skin and subcutaneous tissue

867

9282

0.85

5.05

1.5

—

Covid-19 confirmed case

880

7544

1.18

5.03

1.6

1.5

—

Dentinal caries

341

4331

0.78

4.99

1.5

—

Rheumatoid arthritis

333

3878

0.78

4.93

1.5

—

Bacterial pneumonia (organism specified)

487

5441

0.81

4.90

1.6

1.5

—

Accidents

3120

16973

0.92

4.88

1.5

—

Insulin, combination of fast acting with intermediate-acting or long-acting

791

8555

0.85

4.87

1.5

—

Diabetic nephropathy

1160

0.58

4.85

1.3

1.5

—

Migraine without aura and triptan purchases

829

9608

0.85

4.85

1.4

1.5

—

Rheumatism, unspecified

1459

0.63

4.83

1.5

—

Dental pulpitis 3

1661

10808

1.14

4.82

1.6

1.5

—

Use of pramipexole

1225

0.59

4.82

1.4

1.5

—

Diseases of the musculoskeletal system and connective tissue

2972

16200

0.91

4.79

1.5

—

Other external causes of accidental injury

3123

16973

0.92

4.79

1.5

—

Bacterial Sepsis

272

3169

0.76

4.75

1.5

—

Renal failure

120

1644

0.67

4.75

1.6

1.5

—

Ischaemic heart disease, wide definition

137

1261

0.68

4.75

1.9

1.5

—

Reimbursement for rheumatic diseases

945

10877

0.86

4.73

1.5

—

Adalimumab

160

2248

0.70

4.70

1.3

1.5

—

Diseases of the skin and subcutaneous tissue

3439

18625

0.92

4.68

1.5

—

Other symptoms and signs involving cognitive functions and awareness

279

3399

0.77

4.61

1.5

—

Embedded teeth, including avohilmo

539

6420

0.82

4.60

1.5

—

Complications specific to multiple gestation

174

2.40

4.59

1.5

1.4

—

Other medical care

424

5106

0.81

4.56

1.5

—

Coxarthrosis [arthrosis of hip](FG)

951

0.61

4.55

1.7

1.5

—

Venous complications and haemorrhoids in the puerperium

275

1.98

4.53

1.9

1.5

—

Other condition

211

2826

0.74

4.53

1.4

1.5

—

Diarrhoea and gastroenteritis of presumed infectious origin

2103

20965

0.91

4.52

1.5

—

Presence of other functional implants

137

1407

0.69

4.49

1.6

1.5

—

Insomnia

431

5269

0.81

4.48

1.4

1.5

—

Mouth breathing

323

4094

0.78

4.47

1.4

1.5

—

Sequelae of injuries of head

679

0.48

4.45

1.5

—

Disorders of parathyroid gland

820

0.53

4.45

1.2

1.5

—

Other special examinations and investigations of persons without complaint or reported diagnosis

2188

12161

0.91

4.44

1.5

—

Other coagulation defects

239

1813

1.35

4.43

1.6

1.5

—

Varicose veins

249

2473

0.76

4.42

1.6

1.5

—

Conjunctivitis

2885

23230

1.09

4.41

1.5

—

Emotional disorders starting during childhood or adolecense, excluding more controls

347

4179

0.78

4.40

1.5

1.6

—

Biological medication for rheuma

352

4389

0.79

4.37

1.4

1.5

—

Deposits [accretions] on teeth

999

0.58

4.33

1.6

1.5

—

Demyelinating diseases of the central nervous system

208

2754

0.74

4.26

1.4

1.5

—

Malignant neoplasm of breast, HER-positive

1228

0.62

4.22

1.3

1.5

—

Other and unspecified mental retardation

268

0.29

4.22

1.1

1.5

—

L04AC Interleukin inhibitors

947

0.57

4.21

1.4

1.5

—

Use of biperiden

445

0.38

4.21

1.1

1.5

—

Fracture of lower leg, including ankle

837

9608

0.86

4.19

1.5

—

Persons encountering health services in other circumstances, wide

3903

18911

1.07

4.15

1.5

—

Malignant neoplasm of brain, excluding all cancers (controls excluding all cancers)

580

0.46

4.13

1.2

1.5

—

MS-disease / Multiple Sclerosis

185

2476

0.73

4.13

1.4

1.5

—

Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified

844

9503

0.87

4.11

1.5

—

Mental and behavioural disorders due to use of other stimulants, including caffeine

981

0.58

4.10

1.3

1.5

—

Other chronic obstructive pulmonary disease, including avohilmo

100

1252

0.66

4.08

1.5

—

Respiratory diseases principally affecting the interstitium, IBD co-morbidites

419

0.45

4.06

1.9

1.5

—

Exclusions for E4_PCOS_BROAD

306

3840

0.79

4.04

1.4

1.5

—

Symptoms and signs involving the circulatory and respiratory systems

3986

21334

0.93

4.04

1.5

—

Persons encountering health services for examination and investigation

2221

12161

0.91

4.03

1.5

—

Secondary malignant neoplasm of respiratory and digestive organs, excluding all cancers (controls excluding all cancers)

452

0.40

4.02

1.3

1.5

—

Extracorporeal dialysis

362

0.33

4.01

1.3

1.6

—

Infections of the skin and subcutaneous tissue

1354

15016

0.89

3.99

1.5

—

Other dialysis

211

0.23

3.99

1.2

1.6

—

Asthma, excluding more controls

2504

14483

0.92

3.97

1.5

—

Sodium-glucose co-transporter 2 (SGLT2) inhibitors

1393

0.66

3.95

1.4

1.5

—

Other abnormal uterine and vaginal bleeding

499

4255

0.83

3.94

1.5

—

Trochanteric bursitis

1145

0.62

3.91

1.4

1.5

—

Maternal care for known or suspected disproportion

125

871

1.47

3.91

1.4

1.3

—

COPD

990

0.63

3.91

1.6

—

Bulimia nervosa (incl. atypical)

271

3357

0.76

3.89

1.5

—

Spondylosis

179

2069

0.74

3.89

1.4

1.5

—

Paranoid personality disorder

476

0.42

3.87

1.7

1.5

—

Other viral hepatitis

116

1656

0.69

3.85

1.4

1.5

—

Injury, poisoning and certain other consequences of external causes

2435

13237

0.92

3.84

1.5

—

Dialysis

274

0.32

3.84

1.3

1.6

—

Viral hepatitis

123

1738

0.70

3.82

1.5

—

Other disorders of adrenal gland

820

0.56

3.82

1.5

—

Ill-defined and unknown causes of mortality

101

0.00

3.81

0.0

1.6

—

Other functional intestinal disorders

691

7631

0.86

3.81

1.5

—

Tumor necrosis factor alpha inhibitors

331

4084

0.80

3.81

1.4

1.5

—

Leisure time condition

310

3857

0.80

3.79

1.3

1.5

—

Anomalies of dental arch relationship, including avohilmo

699

7243

0.86

3.78

1.5

—

Mixed disorders of conduct and emotions, excluding more controls

149

1992

0.71

3.78

1.6

—

Cerebral palsy and other paralytic syndromes

123

1740

0.70

3.78

1.4

1.5

—

Complications of anaesthesia during labour and delivery

212

2.16

3.77

1.6

1.5

—

Dorsopathies

3935

21396

0.93

3.77

1.5

—

Other disorders of fluid, electrolyte and acid-base balance

119

1639

0.70

3.77

1.4

1.5

—

Valvular heart disease excluding rheumatic fever

219

2087

0.76

3.74

1.5

—

Pain and other conditions associated with female genital organs and menstrual cycle

1232

13113

0.89

3.74

1.5

—

Crowding of teeth, including avohilmo

478

4666

0.83

3.73

1.5

—

Chronic periodontitis

809

0.57

3.73

1.4

1.6

—

Endocrine, nutritional and metabolic diseases

3953

18879

1.07

3.71

1.5

—

Diabetic retinopathy, excluding more controls

182

1372

0.74

3.69

1.5

—

Superficial injury of wrist and hand

633

7341

0.85

3.68

1.5

—

Hyperparathyroidism

564

0.49

3.66

1.3

1.5

—

Diseases of appendix

1981

19651

0.91

3.66

1.5

—

Non-invasive ventilation

418

4726

0.82

3.66

1.4

1.5

—

Vaginitis/vulvovaginitis/vulvitis/abscess of vulva

1120

10049

1.13

3.64

1.5

—

severe traumatic brain injury, does not include concussion

1283

0.66

3.63

1.5

—

Chronic viral hepatitis

1413

0.67

3.63

1.4

1.5

—

Migraine

2755

21824

1.08

3.62

1.5

—

Tooth eruption problems

1033

11403

0.88

3.60

1.5

—

Other follicular disorders

150

2026

0.73

3.59

1.4

1.5

—

Mixed specific developmental disorders

787

0.58

3.59

1.4

1.5

—

Malignant neoplasm of eye, brain and central nervous system, excluding all cancers (controls excluding all cancers)

694

0.54

3.58

1.3

1.5

—

Fracture at wrist and hand level

648

7499

0.86

3.58

1.5

—

Malignant neoplasm of eye, brain and central nervous system

439

0.43

3.57

1.2

1.5

—

Asthma

2506

14514

0.92

3.56

1.5

—

Sequelae of cerebrovascular disease

813

0.60

3.56

1.6

1.5

—

Myalgia

590

6867

0.85

3.55

1.5

—

Hypothyroidism, strict autoimmune

2722

19366

0.93

3.55

1.5

—

Diseases of arteries, arterioles and capillaries (FINNGEN)

701

0.62

3.54

1.5

—

Heart failure and antihypertensive medication

505

0.56

3.53

1.3

1.5

—

Other disorders of eye and adnexa

268

3355

0.79

3.53

1.5

—

Other and unspecified tonsillitis

1873

17266

0.91

3.51

1.5

—

Appendicitis, broad definition

1975

19619

0.92

3.51

1.5

—

Non-rheumatic valve diseases

214

2024

0.77

3.51

1.5

—

Paroxysmal tachycardia

379

3879

0.82

3.50

1.5

—

Multiple myeloma, Monoclonal gammopathy of undetermined significance (MGUS)

10.06

3.50

2.2

2.8

—

Multiple myeloma

10.06

3.50

2.2

2.8

—

Other ill-defined and unspecified causes of mortality

0.00

3.49

0.0

1.6

—

Personal history of risk-factors, not elsewhere classified

491

0.46

3.49

1.6

1.5

—

Female genital prolapse

349

2470

0.81

3.49

1.5

—

Bitten or struck by other mammals

327

3989

0.81

3.48

1.4

1.5

—

Secondary malignant neoplasm of other and unspecified sites, excluding all cancers (controls excluding all cancers)

573

0.50

3.48

1.2

1.4

—

Visual disturbances and blindness

925

10438

0.88

3.47

1.5

—

Congenital malformations of the nervous system

860

0.59

3.45

1.5

—

Obesity due to excess calories

1696

15523

1.10

3.45

1.5

—

Neuralgia and neuritis, unspecified

734

0.56

3.44

1.3

1.5

—

Bacterial infection, other or unspecified

435

4686

0.83

3.44

1.6

1.5

—

Adhesive capsulitis of shoulder

826

0.59

3.42

1.4

1.5

—

Lateral epicondylitis

1228

0.66

3.42

1.4

1.5

—

Alcohol abuse, main dg, excluding more controls

270

3366

0.79

3.41

1.4

1.5

—

Other headache syndromes

1202

13336

0.90

3.40

1.5

—

Other and unspecified nerve root and plexus disorders, also in other diseases

191

2485

0.76

3.39

1.4

1.5

—

Previous suicide attempt

428

0.44

3.38

1.6

1.5

—

Other diseases of liver

126

1742

0.72

3.38

1.5

—

Coagulation defects, purpura and other haemorrhagic conditions

467

3943

1.20

3.37

1.6

1.5

—

Transport accidents

1677

16214

0.91

3.32

1.5

—

Vitreous haemorrhage

766

0.58

3.30

1.3

1.6

—

Lack of expected normal physiological development

1093

0.66

3.30

1.5

—

Early lumbar disc prolapse, operated

265

3288

0.79

3.29

1.4

1.5

—

Feeding problems of newborn

168

2.13

3.29

1.6

1.5

—

Cough

710

7791

0.87

3.29

1.6

1.5

—

Elevated blood glucose level

1082

0.65

3.28

1.3

1.5

—

Pervasive developmental disorders excl. Autism + Asperger

344

0.39

3.27

1.5

—

Monoplegia

220

0.31

3.26

1.0

1.5

—

Algoneurodystrophy

780

0.59

3.26

1.3

1.5

—

Certain conditions originating in the perinatal period

440

4586

0.83

3.26

1.5

—

malignant neoplasm of female genital organs, excluding all cancers (controls excluding all cancers)

1333

0.69

3.24

1.4

1.5

—

Sequelae of injuries of neck and trunk

364

0.40

3.24

1.2

1.5

—

Exclusion endpoint for clefts

598

0.53

3.23

1.6

1.5

—

Malignant neoplasm of brain

392

0.43

3.23

1.2

1.5

—

COPD related to multimorbidity

460

0.51

3.22

1.3

1.6

—

Gastrointestinal diseases

3146

16803

0.93

3.18

1.5

—

Medical observation and evaluation for suspected diseases and conditions

2198

12161

0.92

3.18

1.6

1.5

—

COPD, early/later onset

932

0.66

3.15

1.6

—

Other chronic obstructive pulmonary disease

918

0.66

3.15

1.6

—

Persistent delusional disorders

615

0.55

3.14

1.4

1.5

—

Monoamine oxidase A inhibitors

1168

0.67

3.13

1.3

1.5

—

Deep bite

242

2640

0.79

3.12

1.5

—

Cerebral cysts

116

1590

0.71

3.12

1.4

1.5

—

Fracture of forearm

1107

11501

0.90

3.11

1.5

—

Benign neoplasm of colon, rectum, anus and anal canal

204

1868

0.78

3.11

1.6

1.5

—

COPD, hospital admissions

931

0.66

3.10

1.6

—

Disorders of continuity of bone

128

1732

0.73

3.09

1.5

—

Other specified congenital malformation syndromes affecting multiple systems

472

0.49

3.08

1.4

1.5

—

Disorders of refraction and accommodation

843

9431

0.88

3.08

1.5

—

General symptoms and signs

3794

20139

0.94

3.08

1.5

—

Cervicalgia

259

3206

0.80

3.07

1.5

—

Chronic kidney disease

1041

0.66

3.06

1.6

1.5

—

Disturbances of skin sensation

758

8567

0.88

3.05

1.5

—

Other symptoms and signs involving general sensations and perceptions

617

0.56

3.02

1.8

1.5

—

Early lumbar disc prolapse operation

270

3309

0.81

3.02

1.4

1.5

—

Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances

175

2247

0.76

3.00

1.4

1.5

—

L02BA Anti-estrogens

1003

0.65

3.00

1.3

1.5

—

Certolizumab pegol

125

933

1.42

3.00

1.5

—

Used for control exclusion in common control thyroid runs

3771

20232

0.94

2.99

1.5

—

Acute alcohol intoxication

336

4042

0.83

2.99

1.5

—

Use of teriflunomide

303

0.38

2.99

1.7

1.5

—

Ehlers-Danlos syndrome

484

0.50

2.98

1.6

1.5

—

Diabetic neuropathy

473

0.50

2.98

1.2

1.5

—

Other inflammation of vagina/vulva

250

2037

1.27

2.97

1.6

1.5

—

Nonalcoholic fatty liver disease

938

0.64

2.96

1.5

—

Visual disturbances

894

10000

0.89

2.96

1.5

—

Brachial plexus disorders

188

2394

0.77

2.95

1.5

—

Soft tissue disorders related to use, overuse and pressure

182

2338

0.78

2.95

1.4

1.5

—

Benign intracranial hypertension

649

0.57

2.91

1.4

1.5

—

Vocal cord dysfunction

230

2659

0.80

2.90

1.4

1.5

—

950

8605

1.13

2.89

1.5

—

Acute suppurative otitis media

1533

15523

0.91

2.89

1.5

—

Causalgia

301

0.39

2.88

1.2

1.5

—

Radiculopathy

1172

0.69

2.88

1.4

1.5

—

Plantar fascial fibromatosis

1063

0.67

2.87

1.4

1.5

—

Emotional disorders and disorders of social functioning with onset specific to childhood

373

4309

0.83

2.87

1.5

1.6

—

Total colectomy operation

632

0.58

2.86

1.6

1.5

—

Total colectomy

632

0.58

2.86

1.6

1.5

—

Hypothyreosis and Thyroxine purchase for inclusion criteria

3131

21922

0.94

2.85

1.5

—

Hypoglycaemia, other or unspecified

1197

0.69

2.82

1.6

1.5

—

Sleep disorders, other/unspecified

1152

0.68

2.82

1.5

—

Strabismus

700

7887

0.88

2.79

1.5

—

Pyogenic granuloma

390

1.59

2.79

1.5

—

Abnormalities of heart beat

754

8403

0.88

2.78

1.5

—

Other and unspecified disorders of psychological development

393

0.48

2.78

1.4

1.5

—

Haemorrhoids and perianal venous thrombosis

319

2648

1.21

2.76

1.5

—

Gestational [pregnancy-induced] oedema and proteinuria without hypertension

291

2408

1.23

2.76

1.5

—

Other disorders of glucose regulation and pancreatic internal secretion

107

1457

0.73

2.74

1.6

1.5

—

Unspecified behavioural syndromes associated with physiological disturbances and physical factors +Physiological and behavioural factors associated with disorders of diseases classified elsewhere

516

0.54

2.73

1.5

—

Dementia, including avohilmo

419

0.58

2.73

1.7

1.6

—

Fracture of femur

1017

0.69

2.72

1.6

—

Thyrotoxicosis, other and/or unspecified

524

4553

1.16

2.72

1.5

—

Dermatitis

1217

13332

0.91

2.72

1.5

—

Combinations of oral blood glucose lowering drugs

590

0.58

2.72

2.5

1.5

—

Disorders of conjunctiva

2947

23257

1.06

2.71

1.5

—

Diffuse brain injury

597

0.58

2.70

1.4

1.6

—

Specific development disorders of scholastic skills

183

2265

0.78

2.70

1.5

1.6

—

COPD, hospital admissions 1, only main diagnosis

714

0.64

2.70

1.7

1.6

—

Acute alcohol intoxication, ICD10

331

3940

0.83

2.70

1.4

1.5

—

Squamous cell neoplasms and carcinomas of the skin, excluding all cancers (controls excluding all cancers)

2.50

2.69

1.8

1.4

—

Open wound of head

636

7109

0.88

2.69

1.5

—

Volume depletion

723

0.62

2.69

1.4

1.5

—

Colectomy operation

894

0.66

2.68

1.5

1.6

—

Conduction disorders

148

1603

0.76

2.68

1.4

1.5

—

Pneumonitis due to solids and liquids

323

0.43

2.67

1.1

1.5

—

Cervical disc disorders

169

2161

0.78

2.67

1.6

1.5

—

Autoimmune diseases

3876

20854

0.95

2.66

1.5

—

Lesion of ulnar nerve

103

1408

0.73

2.66

1.5

1.6

—

Drug-induced neutropenia

571

0.57

2.66

1.5

1.6

—

Habit and impulse disorders

436

0.51

2.66

1.7

1.5

—

Coxarthrosis, primary

660

0.63

2.64

2.0

1.5

—

Malignant neoplasm of breast, ER-negative, excluding all cancers (controls excluding all cancers)

107

1396

0.73

2.63

1.3

1.5

—

Neuromuscular dysfunction of bladder

900

0.66

2.63

1.6

1.5

—

Superficial injury of lower leg

630

7127

0.88

2.63

1.5

—

Malignant neoplasm of breast, HER-negative

1044

0.69

2.63

1.2

1.5

—

Golimumab

773

0.63

2.62

1.3

1.5

—

malignant neoplasm of female genital organs

841

0.65

2.62

1.4

1.5

—

Any dementia, excluding more controls

309

0.52

2.62

2.0

1.6

—

Contact with other sharp object(s)

159

2027

0.77

2.62

1.6

1.5

—

Hyperkinetic disorders (excl. ADHD)

603

0.59

2.61

1.6

1.5

—

Asthma-related infections

1397

14929

0.92

2.60

1.5

—

Asthma, hospital admission 2, infections

1397

14929

0.92

2.60

1.5

—

Diseases of the myoneural junction and muscle

911

0.67

2.60

1.4

1.5

—

Use of fingolimod

463

0.53

2.60

1.2

1.5

—

Temporomandibular joint disorders, including avohilmo

1988

21237

0.93

2.60

1.5

—

Optic atrophy

209

0.38

2.58

1.4

1.5

—

Other noninflammatory disorders of uterus, except cervix

118

1079

0.74

2.58

1.5

—

Diseases of the eye and adnexa

3653

19284

0.95

2.58

1.5

—

Speech therapy

207

2571

0.80

2.58

1.4

1.5

—

Pregnant state, incidental

6.25

2.57

1.7

1.0

—

Chronic periodontitis, complicated

425

0.51

2.57

1.3

1.6

—

Delayed milestone in childhood

356

0.49

2.57

1.4

1.5

—

Other disorders of penis

4.01

2.56

2.0

3.1

—

Disorder of the sleep-wake schedule

543

0.57

2.55

1.4

1.5

—

Lung cancer and mesothelioma

167

0.36

2.55

1.3

1.7

—

Other metabolic disorders

220

2701

0.81

2.52

1.4

1.5

—

Chronic rhinitis, nasopharyngitis and pharyngitis

643

7249

0.88

2.52

1.5

—

Dementia

392

0.58

2.52

1.8

1.6

—

Hidradenitis suppurativa

1333

0.72

2.51

1.4

1.5

—

Corns and callosities

611

0.60

2.51

2.0

1.5

—

COPD (mode)

654

0.65

2.51

1.7

1.6

—

Vasomotor and allergic rhinitis

1417

15115

0.92

2.50

1.5

—

Other respiratory disorders and diseases

831

0.66

2.49

1.5

—

Other diseases of the respiratory system

831

0.66

2.49

1.5

—

158

0.31

2.47

1.0

1.5

—

Irritable bowel syndrome

733

8182

0.89

2.46

1.5

—

3843

19292

1.05

2.46

1.5

—

Pulmonary heart disease, diseases of pulmonary circulation

145

1866

0.77

2.45

1.7

1.5

—

Psoriasis

316

3745

0.84

2.45

1.6

1.5

—

Glomerular diseases

164

2076

0.79

2.45

1.6

1.5

—

Fibroblastic disorders

1285

0.73

2.44

1.4

1.5

—

Primary ovarian failure

787

0.65

2.43

1.4

1.5

—

Glomerular disorders in diseases classified elsewhere

1235

0.72

2.43

1.4

1.5

—

Malignant neoplasm of bronchus and lung, excluding all cancers (controls excluding all cancers)

146

0.34

2.43

1.3

—

Parodontitis, under 40 years, or operation codes

824

9062

0.89

2.43

1.5

—

Asthma (only as main-diagnosis), excluding more controls

2282

14483

0.94

2.41

1.5

—

Myelodysplastic syndrome

5.08

2.41

2.8

1.4

—

Congenital malformations of the musculoskeletal system, not elsewhere classified

592

0.60

2.41

1.6

1.5

—

Triptan medication for migraine, min. 3 purchases

2754

22971

0.94

2.41

1.4

1.5

—

Disorders of optic nerve and visual pathways

197

2428

0.80

2.40

1.5

—

Parodontitis, under 40 years

824

9056

0.89

2.40

1.5

—

Abnormal results of function studies

1299

0.73

2.40

1.4

1.5

—

Other and unspecified dermatitis

1021

11198

0.91

2.39

1.5

—

Complications following abortion and ectopic and molar pregnancy

290

1.61

2.39

1.6

1.4

—

Unknown and unspecified causes of morbidity

105

1400

0.74

2.38

1.5

—

Diseases of salivary glands

284

3384

0.83

2.38

1.5

—

Other specified/unspecified systemic involvement of connective tissue

901

0.68

2.38

1.4

1.5

—

Thyrotoxicosis

581

5139

1.14

2.36

1.5

—

Other disorders of teeth and supporting structures

258

3097

0.83

2.34

1.5

—

Hypokalaemia

901

0.68

2.34

1.5

—

Postprocedural endocrine and metabolic disorders, not elsewhere classified

207

2530

0.81

2.31

1.4

1.5

—

Other local infections of skin and subcutaneous tissue

112

1473

0.75

2.30

1.5

—

Other fall from one level to another

535

6051

0.88

2.30

1.5

—

Other shoulder lesions

140

1786

0.78

2.30

1.4

1.5

—

Recurrent dislocation of patella

292

3425

0.83

2.29

1.5

—

Pilonidal cyst

208

2534

0.81

2.29

1.5

—

Adrenocortical insufficiency

494

0.58

2.29

1.5

—

Any dementia

299

0.54

2.28

2.0

1.6

—

Specific development disorders of speech and language

180

2136

0.80

2.28

1.6

1.5

—

Inflammatory diseases of female pelvic organs

3130

22412

1.06

2.28

1.5

—

Agranulocytosis

1220

0.73

2.27

1.5

—

Other and unspecified polyneuropathies, also in other diseases

694

0.65

2.27

1.5

1.6

—

Other strabismus

667

7419

0.89

2.27

1.5

—

Other mental disorders due to brain damage and dysfunction and to physical disease

445

0.56

2.26

1.5

—

Ganglion

493

5601

0.87

2.25

1.5

—

Chronic pancreatitis

406

0.54

2.25

1.3

1.6

—

Other symptoms and signs involving the urinary system

116

881

1.33

2.25

2.0

1.5

—

Heart failure, strict

706

0.70

2.23

1.3

1.6

—

Papulosquamous disorders

417

4795

0.87

2.22

1.5

—

Crossbite

161

1860

0.79

2.22

1.4

1.5

—

Haemorrhage from respiratory passages

239

2669

0.83

2.21

1.4

1.5

—

Degenerative diseases of the nervous system

151

0.40

2.20

1.0

1.7

—

Mixed disorders of conduct and emotions

149

1846

0.77

2.20

1.6

—

Injury of muscle and tendon at shoulder and upper arm level

1250

0.74

2.19

1.4

1.5

—

Fungal Sepsis

348

0.51

2.19

1.4

1.5

—

Asthma (mode)

2510

14596

0.94

2.18

1.5

—

Unspecified acute lower respiratory infection

171

2119

0.80

2.17

1.5

—

358

4140

0.86

2.17

1.6

1.5

—

Methotrexate

183

2251

0.81

2.17

1.5

—

Other and unspecified local infections of skin and subcutaneous tissue

111

1447

0.76

2.17

1.5

—

Secondary hypertension

784

0.68

2.17

1.5

—

Myopia

489

5526

0.87

2.16

1.5

—

Allergic rhinitis

1313

14013

0.92

2.16

1.5

—

COPD, hospital admission 2, with asthma infections

617

0.66

2.16

1.5

1.6

—

Heart failure,strict

685

0.70

2.14

1.3

1.6

—

Mixed connective tissue disease

1067

0.72

2.14

1.4

1.5

—

Hepatic failure, not elsewhere classified

238

0.42

2.14

1.6

1.5

—

COPD, hospital admissions 3, with asthma pneumonia sepsis

373

0.57

2.13

1.6

—

All influenza (not pneumonia)

222

2672

0.83

2.13

1.4

1.5

—

Extrapyramidal and movement disorders

253

3015

0.84

2.13

1.3

1.5

—

Follow-up care involving plastic surgery

496

0.60

2.12

1.3

1.5

—

Viral and other specified intestinal infections

1140

12042

0.92

2.12

1.5

—

Uterine polyps

130

1013

1.29

2.12

1.5

—

Ulcer of lower limb, not elsewhere classified

423

0.57

2.11

1.5

1.6

—

Pulmonary embolism

132

1681

0.78

2.11

1.6

1.5

—

Other disorders of bone

401

4595

0.87

2.10

1.5

—

Parodontitis, operation under 40 years and operation codes

793

8666

0.90

2.10

1.5

—

Pulmonary heart disease

132

1679

0.78

2.09

1.6

1.5

—

Other adrenocortical overactivity

280

0.47

2.09

1.6

1.5

—

Unspecific neurodegenerative disorder

221

0.50

2.09

1.2

1.7

—

Dislocation, sprain and strain of joints and ligaments at ankle and foot level

1576

16822

0.93

2.09

1.5

—

Functional dyspepsia

442

5031

0.87

2.08

1.5

—

Manic episode

802

0.68

2.08

1.4

1.5

—

Toxic effect of other and unspecified substances

425

0.57

2.08

1.4

1.5

—

Parodontitis, under 40 years and operation codes

793

8661

0.90

2.08

1.5

—

Medial epicondylitis

342

0.52

2.08

1.6

1.5

—

All-cause Heart Failure

688

0.71

2.07

1.3

1.6

—

Cerebral palsy

548

0.62

2.07

1.5

—

Intermittent heterotropia

227

2699

0.82

2.06

1.5

—

Dissocial personality disorder

175

0.39

2.06

1.1

1.5

—

Major coronary heart disease event excluding revascularizations

520

0.68

2.05

2.0

1.6

—

Direct fill therapy

225

2691

0.83

2.05

1.4

1.5

—

Nonsuppurative otitis media

1563

14414

0.93

2.05

1.5

—

Acute appendicitis

1899

19047

0.94

2.04

1.5

—

Other sleep disorders

162

2001

0.80

2.04

1.4

1.5

—

Squamous cell neoplasms and carcinomas of the skin

2.18

2.04

1.8

1.7

—

Angina pectoris

500

0.67

2.04

1.5

1.6

—

Asthma-related pneumonia

443

5028

0.88

2.03

1.5

—

Nystagmus and other irregular eye movements

322

0.51

2.03

1.5

—

Other septicaemia

292

3357

0.85

2.03

1.5

—

Continuous positive airway pressure

716

0.70

2.02

1.2

1.5

—

Childhood asthma (age<16), excluding more controls

1280

10889

0.92

2.02

1.5

—

Fracture of shoulder and upper arm

461

5219

0.88

2.01

1.5

—

Astigmatism

138

1724

0.79

2.01

1.4

1.5

—

Childhood asthma (age<16)

1280

10891

0.92

2.01

1.5

—

Postmenopausal bleeding

0.39

2.01

1.9

1.4

—

Other specified/unspecified arthritis

458

5187

0.88

2.01

1.5

—

Asthma, hospital admissions 3, pneumonia

447

5064

0.88

2.00

1.5

—

Asthma-related pneumonia or sepsis

447

5064

0.88

2.00

1.5

—

Other orthopaedic follow-up care

658

0.66

2.00

1.5

—

Other neurotic disorders

439

0.59

2.00

1.2

1.5

—

Motor disorders, excluding more controls

506

0.62

1.99

1.5

1.6

—

Optic neuritis

107

1375

0.76

1.99

1.4

1.5

—

Pain, not elsewhere classified

655

7256

0.90

1.98

1.4

1.5

—

Injury of muscle and tendon at hip and thigh level

962

0.72

1.98

1.5

—

Disorders of speech understanding and production

1238

0.75

1.97

1.5

—

Congenital malformations of uterus and cervix

177

1470

1.26

1.96

1.5

—

Other disorders of nervous system

296

0.50

1.95

1.4

1.5

—

Diseases of peritoneum

820

0.70

1.94

1.4

1.5

—

Panniculitis affecting regions of neck and back

544

0.64

1.93

1.5

—

ILD, hospital admission 2, with pulmonary infections

282

0.49

1.93

2.2

1.6

—

Polycystic ovarian syndrome

609

5539

1.13

1.93

1.5

—

Preparation and fitting of bite rail to mouth

294

3416

0.85

1.93

1.5

—

Any prescribed medicine buy

1.76

1.91

1.7

1.4

—

Trigger finger

114

1456

0.78

1.91

1.4

1.5

—

Other and unspecified disorders of adult personality and behaviour

271

0.48

1.91

1.1

1.5

—

Benign neoplasm: Colon

149

1419

0.80

1.91

1.7

1.5

—

Mental and behavioural disorders of puerperium, not classified elsewhere

648

1.39

1.91

1.5

—

Alcohol abuse counselling and surveillance

251

0.47

1.90

1.3

1.5

—

Rosacea

174

2114

0.82

1.90

1.5

—

Polyuria

162

1987

0.81

1.90

1.5

—

Atherosclerosis, excluding cerebral and coronary sclerosis

338

0.59

1.89

1.7

1.6

—

Hydronephrosis

165

1344

1.24

1.88

1.6

1.5

—

Diplopia

138

1718

0.80

1.88

1.5

—

Benign leiomyoma with endometriosis

1092

0.75

1.88

1.3

1.5

—

Seborrhoeic keratosis

704

1.32

1.88

1.4

1.6

—

Benign leiomyoma with endometriosis

1091

0.75

1.87

1.3

1.4

—

Enthesopathies of lower limb, excluding foot

296

3435

0.86

1.87

1.5

—

Malignant neoplasm of cervix uteri, excluding all cancers (controls excluding all cancers)

608

0.66

1.87

1.4

1.5

—

Thyrotoxicosis with diffuse goitre

399

3511

1.15

1.86

1.4

1.5

—

Malignant neoplasm of thyroid gland

835

0.71

1.86

1.4

1.5

—

Superficial injury of ankle and foot

402

4550

0.87

1.86

1.5

—

Acute peritonitis

430

0.60

1.85

1.5

—

Diseases of the digestive system

571

6337

0.90

1.85

1.5

—

Other acute lower respiratory infections

1164

11961

0.93

1.85

1.5

—

Chronic hepatitis, not elsewhere classified

428

0.60

1.85

1.7

1.5

—

Emotional disorders starting during childhood or adolescence

348

3914

0.86

1.84

1.5

—

Unspecified haematuria

218

2223

0.84

1.84

1.5

—

Benign mammary dysplasia

141

1746

0.80

1.84

1.4

1.5

—

Other CVD (FINNGEN)

622

0.71

1.83

2.0

1.5

—

ILD, hospital admissions 3, with pneumonia sepsis

198

0.45

1.83

2.8

1.5

—

Spinal stenosis

693

0.72

1.83

1.4

1.5

—

Alzheimer disease, including avohilmo

122

0.41

1.83

1.0

1.8

—

Alcohol abuse, main dg

270

3145

0.85

1.83

1.4

1.5

—

Poisoning by narcotics and psychodysleptics [hallucinogens]

566

0.65

1.82

1.4

1.5

—

Toxic effects of substances chiefly nonmedicinal as to source

256

2990

0.85

1.82

1.5

—

Implicit fungal Sepsis

326

0.55

1.82

1.4

1.5

—

499

0.63

1.81

1.3

1.5

—

Crohn's disease of large intestine

1226

0.76

1.81

1.5

—

Cystic fibrosis with intestinal manifestations

0.00

1.81

0.0

1.5

—

SLE (Finngen)

676

0.68

1.81

1.5

—

Systemic lupus erythematosus

676

0.68

1.81

1.5

—

Ocular pain

174

2098

0.82

1.81

1.4

1.5

—

Sequelae of injuries, of poisoning and of other consequences of external causes

319

3670

0.87

1.80

1.5

—

Mental and behavioural disorders associated with the puerperium

654

1.37

1.80

1.5

—

Other and unspecified injuries of lower leg

164

1988

0.82

1.80

1.5

—

DVT of lower extremities and pulmonary embolism

235

2761

0.85

1.80

1.6

1.5

—

Complications of medical and surgical care

1315

13369

0.93

1.79

1.5

—

Drugs, medicaments and biological substances causing adverse effects in therapeutic use

137

1693

0.80

1.79

1.5

—

Congenital malformations, deformations and chromosomal abnormalities

2288

23059

0.95

1.79

1.5

—

Unspecified privation

149

1826

0.81

1.79

1.6

1.5

—

Urticaria and erythema

1089

11724

0.92

1.78

1.5

—

Neurofibromatosis, type 2

0.00

1.78

0.0

1.5

—

Venous thromboembolism

390

4297

0.88

1.78

1.6

1.5

—

Hypothyroidism, other/unspecified

3119

21522

0.95

1.77

1.5

—

Asthma (only as main-diagnosis)

2283

14514

0.95

1.77

1.5

—

Struck by thrown, projected or falling objec

928

0.73

1.77

1.5

—

Pustular psoriasis

448

0.62

1.77

1.6

1.5

—

Non-Hodgkin lymphoma, all, excluding all cancers (controls excluding all cancers)

437

1.40

1.77

1.9

1.5

—

Arthropod-borne viral fevers and viral haemorrhagic fevers

931

0.74

1.77

1.4

1.5

—

Pedal cyclist injured in transport accident

504

5619

0.89

1.77

1.5

—

Cholecystitis

863

0.73

1.76

1.3

1.5

—

TMD related operations

397

4485

0.88

1.76

1.5

—

Viral Sepsis

218

2577

0.84

1.76

1.6

1.5

—

Fracture of foot, except ankle

613

6761

0.90

1.76

1.5

—

ICD-8 DM (Sub-endpoint used for defining DM endpoints)

284

0.52

1.75

1.4

1.3

—

Erythema intertrigo

193

0.46

1.74

1.6

1.5

—

Any mental disorder, or suicide (or attempt), or psychic disorders complicating pregnancy, partum or puerperum or nerve system disorders, excluding more controls

1650

15564

1.07

1.74

1.5

—

Injury of muscle and tendon at wrist and hand level

128

1590

0.80

1.73

1.5

—

Cardiac arrest

211

0.49

1.73

1.4

1.5

—

Malignant neoplasm of cervix uteri

380

0.59

1.73

1.6

1.5

—

Other disorders of patella

424

4767

0.88

1.73

1.5

—

Convergent concomitant strabismus

164

1976

0.82

1.73

1.5

—

Other and unspecified rosacea

1198

0.77

1.73

1.4

1.5

—

Clefts and syndromes for tooth agenesis exclusion, including avohilmo

1098

0.76

1.73

1.4

1.5

—

Explicit fungal Sepsis

0.00

1.73

0.0

1.5

—

Implicit viral Sepsis

218

2572

0.84

1.73

1.6

1.5

—

Other disorders originating in the perinatal period

294

1.52

1.72

1.6

1.5

—

Intentional self-harm by jumping from a high place

186

0.46

1.72

2.0

1.5

—

Impingement syndrome of shoulder

963

0.75

1.72

1.5

—

Traumatic subdural haemorrhage

278

0.53

1.71

1.5

1.7

—

Shock, not elsewhere classified

0.00

1.71

0.0

1.6

—

Superficial injury of shoulder and upper arm

183

2186

0.83

1.70

1.6

1.5

—

Myelodysplastic syndrome, excluding all cancers (controls excluding all cancers)

1.93

1.70

2.6

1.4

—

Other sexually transmitted chlamydial diseases

583

5312

1.12

1.70

1.5

—

Other enthesopathy of foot (+metatarsalgia)

151

1837

0.82

1.70

1.4

1.5

—

Dislocation, sprain and strain of joints and ligaments of shoulder girdle

381

4312

0.88

1.70

1.5

—

L04AD Calcineurin inhibitors

110

1385

0.79

1.70

1.6

1.5

—

Coxarthrosis, primary, with hip surgery

352

0.59

1.70

1.5

—

Malignant neoplasm of endocrine gland

889

0.74

1.70

1.4

1.5

—

Viral haemorrhagic fevers, not elsewhere classified/unspecified

832

0.73

1.69

1.5

—

Torsion of ovary, ovarian pedicle and fallopian tube

118

948

1.28

1.69

1.4

1.5

—

Other respiratory diseases principally affecting the interstitium

529

0.66

1.69

1.8

1.6

—

Other interstitial pulmonary diseases

395

0.61

1.69

2.0

1.6

—

Interstitial lung disease endpoints

395

0.61

1.69

2.0

1.6

—

Interstitial lung disease

395

0.61

1.69

2.0

1.6

—

Lung diseases due to external agents

600

0.68

1.69

1.2

1.5

—

Obesity, other/unspecified

1130

10529

1.08

1.69

1.5

—

Abnormal findings on diagnostic imaging of lung

132

1589

0.81

1.69

1.7

1.5

—

Autonomic disorders

266

0.52

1.69

1.4

1.5

—

Fall on same level involving ice and snow

1055

11354

0.93

1.68

1.5

—

Mental and behavioural disorders due to cannabinoids

973

0.75

1.68

1.5

—

Other/unspecified enthesopathies of lower limb, excluding foot

105

1326

0.78

1.68

1.4

1.5

—

Polyneuropathies and other disorders of the peripheral nervous system

993

0.75

1.68

1.4

1.5

—

Status epilepticus

429

0.62

1.68

1.3

1.5

—

All influenza

362

4104

0.88

1.68

1.5

—

Superficial injury of forearm

280

3220

0.86

1.67

1.6

1.5

—

Cutaneous abscess, furuncle and carbuncle

554

6126

0.90

1.67

1.6

1.5

—

1247

13222

0.93

1.67

1.5

—

Fall on and from stairs and steps

378

4272

0.88

1.67

1.5

—

Other acute viral hepatitis

224

0.48

1.66

1.5

—

LSIL lesion of the cervix uteri, vagina or vulva

617

6763

0.90

1.66

1.4

1.5

—

Mandibular retrognathia

261

2249

1.17

1.66

1.5

—

ILD, hospital admissions

393

0.61

1.66

2.0

1.6

—

Assault

341

3870

0.87

1.66

1.5

—

Other and unspecified follicular disorders

733

0.71

1.65

1.4

1.5

—

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

Coding

Definition

OMOP mapping QC

Cohort

Year of birth distribution

Age at first measurement

Age at last measurement

Age at start of registry

Duration from first to last measurement

Statistics

Number of measurements over the years

Number of measurements per person

Distribution of lab values

Value range per person

LabWAS