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Keratoconus

DOID EFO Endpoint Browser PheWeb

H7_CORNEALDEFORM

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H18.6
  • Hospital discharge: ICD-9 — 3716
  • Hospital discharge: ICD-8 — 37103
  • Cause of death: ICD-10 — H18.6
  • Cause of death: ICD-9 — 3716
  • Cause of death: ICD-8 — 37103

2 out of 7 registries used, show all original rules.

1057

4. Check minimum number of events

None

1057

5. Include endpoints

None

1057

6. Filter based on genotype QC (FinnGen only)

954

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H18
Name in latin
Keratoconus

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7756 2530 5162
Only index persons 7472 2441 5031
Unadjusted period prevalence (%)
Whole population 0.12 0.07 0.14
Only index persons 0.16 0.09 0.19
Median age at first event (years)
Whole population 36.99 41.37 34.91
Only index persons 36.87 41.09 34.82

-FinnGen-

Key figures

All Female Male
Number of individuals 954 416 538
Unadjusted period prevalence (%) 0.20 0.15 0.25
Median age at first event (years) 41.86 44.53 39.79

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1005
Matched controls
10050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.6
ICD-10 Finland
Keratoconus
4503599627370496.0
307.7
984
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
378.9
263.7
255
9
XCW99
NOMESCO Finland
Other investigative procedure of eye
10.7
236.0
306
394
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
230.3
212
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
9.6
215.3
305
436
CGG11
NOMESCO Finland
Corneal cross-linking
+∞
183.1
170
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
158.6
148
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
345.4
148.9
147
5
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.2
146.9
629
2434
H52.2
ICD-10 Finland
Astigmatism
18.1
142.7
119
74
TCG10
NOMESCO Finland
Removal of sutures from cornea
710.3
129.5
125
*
H16.0
ICD-10 Finland
Corneal ulcer
14.5
119.6
112
86
Z3229
NOMESCO Finland
Other healthcare associate professional
6.5
104.6
192
350
WX140
NOMESCO Finland
Parabulbar anesthesy
9.6
102.2
128
151
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
961.7
91.3
88
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.4
87.8
202
451
ZXA10
NOMESCO Finland
Bilateral
4.1
81.0
283
875
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.5
79.9
416
1677
3716A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Keratoconus
+∞
78.2
74
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.8
75.0
298
1002
S01BA04
ATC
prednisolone; ophthalmic
17.2
71.5
60
37
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.0
70.4
243
738
XCK10
NOMESCO Finland
Photography of fundus of eye
5.0
69.5
170
396
CGD40
NOMESCO Finland
Implantation of intracorneal ring segments
+∞
66.4
63
*
S01BA01
ATC
dexamethasone; ophthalmic
9.2
60.5
76
89
WX002
NOMESCO Finland
Sedation and analgesia
3.4
59.7
277
1014
H16.9
ICD-10 Finland
Keratitis, unspecified
134.3
59.6
63
5
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.5
57.5
121
246
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.3
56.1
161
423
3604
FHL
Penetration of the cornea
+∞
51.5
49
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.0
50.7
290
1188
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
50.4
48
*
H26.2
ICD-10 Finland
Complicated cataract
17.1
48.9
41
25
S01ED01
ATC
timolol; ophthalmic
9.2
46.2
57
65
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
125.9
45.2
48
*
37103
ICD-8 Finland
Corneal opacity, Keratoconus
+∞
45.1
43
*
ZXA05
NOMESCO Finland
Left side
2.8
44.9
294
1285
H18.7
ICD-10 Finland
Other corneal deformities
+∞
44.1
42
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.8
38.6
93
211
ZXA00
NOMESCO Finland
Right side
2.6
38.0
305
1460
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
37.7
36
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
380.9
37.3
37
*
H26.4
ICD-10 Finland
After-cataract
4.1
36.7
108
286
H18.4
ICD-10 Finland
Corneal degeneration
191.9
36.0
37
*
S01AD03
ATC
aciclovir; ophthalmic
6.6
35.8
59
94
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
34.6
33
*
CG2S4
NOMESCO Finland
Photography of cornea
124.3
33.9
36
*
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
32.5
31
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
31.5
220
975
S01EA05
ATC
brimonidine; ophthalmic
9.4
31.4
38
42
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
30.4
29
*
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
+∞
28.3
27
*
S01GX01
ATC
cromoglicic acid; ophthalmic
2.3
28.2
261
1309
ZXD20
NOMESCO Finland
Day surgery
2.7
27.7
168
690
CGF10
NOMESCO Finland
Suture of laceration of cornea
278.2
26.8
27
*
Z3231
NOMESCO Finland
Registered nurse
2.2
26.7
305
1665
D11AH01
ATC
tacrolimus; topical
9.9
26.0
30
31
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
256.2
24.8
25
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
92.5
24.8
27
*
H26.02
ICD-10 Finland
Presenil cataract
5.4
24.1
48
92
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
6.4
23.8
40
65
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
23.8
379
2325
S01AX11
ATC
[U] ofloxacin
4.9
23.4
52
110
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
122.8
22.7
24
*
H18.8
ICD-10 Finland
Other specified disorders of cornea
122.8
22.7
24
*
S01EC01
ATC
acetazolamide; systemic
7.1
22.6
34
49
XCK00
NOMESCO Finland
Perimetry
3.8
22.0
68
186
H18.2
ICD-10 Finland
Other corneal oedema
+∞
22.0
21
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
22.0
357
2192
S01FA01
ATC
atropine; ophthalmic
28.7
21.0
28
10
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
214.3
20.6
21
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
112.4
20.6
22
*
H16.8
ICD-10 Finland
Other keratitis
112.4
20.6
22
*
L20.0
ICD-10 Finland
Besnier prurigo
2.8
20.4
114
446
ZXE00
NOMESCO Finland
One hour or less
1.9
18.8
386
2529
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
18.8
18
*
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
18.8
18
*
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
6.2
18.7
32
53
S01AA12
ATC
tobramycin; ophthalmic
102.0
18.6
20
*
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
18.3
131
578
3606
FHL
Keratophakic corneal surgery
+∞
17.8
17
*
S01EA03
ATC
apraclonidine; ophthalmic
16.3
17.1
27
17
CGG20
NOMESCO Finland
Epikeratofakia or keratofakia
+∞
16.7
16
*
D07AA02
ATC
hydrocortisone; topical
2.1
16.7
171
878
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
14.6
16.4
27
19
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
15.7
15
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
162.4
15.5
16
*
S01BA07
ATC
fluorometholone; ophthalmic
5.6
15.3
29
53
S01BC03
ATC
diclofenac; ophthalmic
5.3
14.9
30
58
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
152.1
14.5
15
*
S01ED51
ATC
timolol, combinations; ophthalmic
2.9
14.4
68
243
CFD10
NOMESCO Finland
Repair of conjunctiva
76.2
13.6
15
*
H02AB06
ATC
prednisolone; systemic
1.7
13.4
448
3286
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
40.6
13.2
16
*
E000001, ,
ATC
1.9
13.0
203
1201
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.5
12.6
81
339
H18.0
ICD-10 Finland
Corneal pigmentations and deposits
+∞
12.5
12
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
12.5
12
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
131.6
12.5
13
*
S01AA01
ATC
chloramphenicol; ophthalmic
3.0
12.4
56
195
9881
FHL
Bandage replacement, suture or spike removal, or the like in an operating room or anesthesia
38.0
12.2
15
*
S01EE01
ATC
latanoprost; ophthalmic
3.1
12.1
51
171
S01BC05
ATC
ketorolac; ophthalmic
3.9
11.5
34
90
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
13.8
11.5
19
14
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
11.5
11
*
S01GX08
ATC
ketotifen; ophthalmic
2.8
11.4
57
210
CD2S4
NOMESCO Finland
Photography of eye
12.1
10.9
19
16
CKD60
NOMESCO Finland
Anterior vitrectomy
15.7
10.8
17
11
S01XA18
ATC
ciclosporin; ophthalmic
13.1
10.7
18
14
Z96.7
ICD-10 Finland
Presence of other bone and tendon implants
+∞
10.4
10
*
L04AD01
ATC
ciclosporin; systemic
4.3
10.3
26
61
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
32.9
10.3
13
*
XCH00
NOMESCO Finland
Eye pressure measurement
3.0
10.3
45
154
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
8.9
10.3
21
24
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
40.5
10.0
12
*
E0000UV, ,
ATC
1.6
9.9
390
2915
H02AB04
ATC
methylprednisolone; systemic
1.9
9.8
132
741
E000002, ,
ATC
2.0
9.7
111
589
H57.1
ICD-10 Finland
Ocular pain
2.9
9.7
44
154
H18.3
ICD-10 Finland
Changes in corneal membranes
+∞
9.4
9
*
CGE10
NOMESCO Finland
Keratectomy
+∞
9.4
9
*
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.2
9.1
76
357
D07AB08
ATC
desonide; topical
2.0
9.1
109
587
H27.0
ICD-10 Finland
Aphakia
18.8
8.9
13
7
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.3
8.9
65
289
D11AH02
ATC
pimecrolimus; topical
12.7
8.9
15
12
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.0
8.7
101
538
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.0
8.7
37
125
L20
ICD-10 Finland
Atopic dermatitis
2.9
8.7
41
147
CS494
NOMESCO Finland
Other visual field testing
3.6
8.6
28
80
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
9.1
8.6
17
19
D11AX14
ATC
[U] tacrolimus
10.1
8.5
16
16
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
4.6
8.1
19
42
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
33.6
8.1
10
*
R03BA05
ATC
fluticasone; inhalant
1.7
8.0
171
1097
D07AC01
ATC
betamethasone; topical
1.5
8.0
331
2475
S01EE03
ATC
bimatoprost; ophthalmic
4.3
8.0
20
47
Z2221
NOMESCO Finland
Medical doctor
1.6
7.9
241
1685
J05AB01
ATC
aciclovir; systemic
1.6
7.9
194
1289
S01EE05
ATC
tafluprost; ophthalmic
3.1
7.9
32
105
S01EC04
ATC
brinzolamide; ophthalmic
3.2
7.9
30
95
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
7.0
7.8
18
26
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
7.8
269
1935
L04AA01
ATC
[U] ciclosporin
6.4
7.7
19
30
S01FA02
ATC
scopolamine; ophthalmic
15.2
7.7
12
8
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
45.3
7.7
9
*
S01EX03, ,
ATC
8.1
7.6
16
20
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
80.7
7.4
8
*
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
80.7
7.4
8
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
80.7
7.4
8
*
CDW99
NOMESCO Finland
Other operation on eyeball
+∞
7.3
7
*
CGD00
NOMESCO Finland
Keratotomy for error of refraction
+∞
7.3
7
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
7.3
7
*
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
7.3
7
*
N05BB01
ATC
hydroxyzine; systemic
2.2
7.3
62
295
R06AX27
ATC
desloratadine; oral
1.5
7.1
283
2090
S01AX12
ATC
[U] norfloxacin
12.1
7.1
12
10
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
6.8
6.8
16
24
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
40.3
6.8
8
*
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
16.8
6.8
10
6
E66.01
ICD-10 Finland
Obesity due to excess calories
1.8
6.7
98
563
F29
ICPC
Eye symptom/complaint other
1.8
6.7
98
565
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
6.6
171
1148
S01GX05
ATC
lodoxamide; ophthalmic
4.2
6.6
17
41
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.8
6.5
92
524
E66.8
ICD-10 Finland
Other obesity
2.1
6.5
61
302
114
Kela drug reimbursment
Glaucoma
2.2
6.5
54
255
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
70.3
6.4
7
*
CGF20
NOMESCO Finland
Suture of laceration of cornea with plastic repair of conjunctiva
70.3
6.4
7
*
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
2.8
6.3
30
109
CJA10
NOMESCO Finland
Implantation of phakic lens in posterior chamber
+∞
6.3
6
*
CGF35
NOMESCO Finland
Repair of cornea using graft
+∞
6.3
6
*
CJF50
NOMESCO Finland
Removal and implantation of artificial lens in posterior chamber
+∞
6.3
6
*
37108
ICD-8 Finland
Corneal opacity, Alia definita
+∞
6.3
6
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
6.3
6
*
37102
ICD-8 Finland
Corneal opacity, Dystrophia corneae hereditaria
+∞
6.3
6
*
S05.2
ICD-10 Finland
Ocular laceration and rupture with prolapse or loss of intraocular tissue
26.8
6.2
8
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
6.2
705
6242
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
6.2
121
756
A46
ICD-10 Finland
Erysipelas
1.7
6.1
124
784

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
438
3509
1.44
7.26
5.7
5.4
36.75
36.66
g/l
0.14
409
3316
854
7809
1.62
6.93
5.5
4.9
1.90
1.85
mu/l
0.57
795
7335
178
1210
1.57
6.52
2.1
2.1
—
—
—
0
0
730
6493
1.45
6.39
4.6
4.1
14.69
14.64
pmol/l
0.20
679
6047
870
8082
1.57
5.57
6.2
5.7
39.12
38.67
mmol/mol
0.74
821
7727
711
6426
1.36
4.70
8.4
8.3
76.94
78.07
u/l
0.29
680
6157
408
3411
1.33
4.57
2.2
2.0
92.76
97.44
pmol/l
1.12
221
1860
316
2567
1.34
4.24
4.5
4.3
11.14
8.91
mg/mmol
0.30
201
1655
343
2823
1.33
4.20
6.6
6.9
—
—
—
0
0
310
2522
1.33
4.10
4.0
3.7
81.03
52.82
mg/l
0.54
204
1667
249
1964
1.36
4.04
2.4
2.2
2.89
2.82
mg/l
0.18
209
1706
274
2204
1.33
3.89
2.8
2.8
364.40
348.20
umol/l
1.85
247
2004
954
9185
1.76
3.86
19.8
17.4
79.21
76.80
umol/l
1.56
945
9108
9
15
6.04
3.82
1.2
2.3
—
—
—
0
0
900
8577
1.47
3.48
18.2
15.9
139.76
139.71
mmol/l
0.31
885
8426
24
106
2.30
3.47
1.8
1.6
433.05
315.49
mu/l
0.36
19
84
901
8601
1.46
3.32
18.5
16.0
3.97
3.96
mmol/l
0.06
886
8430
144
1074
1.40
3.27
1.7
1.6
1118.46
1168.03
nmol/l
0.24
106
820
82
548
1.54
3.26
5.3
4.4
102.69
85.33
ng/l
0.86
75
490
13
43
3.05
3.26
1.7
1.4
125.46
151.81
nmol/l
1.18
13
43
317
2670
1.27
3.09
2.9
2.7
84.44
59.19
u/l
0.53
295
2514
33
174
1.93
3.08
2.1
2.3
137.16
132.51
g/l
0.44
25
137
914
8771
1.46
3.04
5.7
5.3
2.77
2.82
mmol/l
0.95
855
8329
276
2303
1.27
2.88
5.6
4.4
7.40
7.40
ph
0.08
197
1616
458
4052
1.24
2.86
3.3
3.0
114.84
127.05
ug/l
0.82
422
3837
946
9157
1.56
2.85
12.5
11.3
31.40
29.24
u/l
1.05
925
8973
171
1342
1.33
2.82
2.9
2.6
14.00
13.94
umol/l
0.03
157
1254
335
2870
1.25
2.78
3.7
3.6
8.25
8.33
mmol/l
0.10
285
2492
428
3775
1.23
2.71
2.8
2.5
73.63
74.42
nmol/l
0.24
389
3488
433
3830
1.23
2.65
11.6
11.1
0.00
0.00
e9/l
0.10
368
3143
256
2138
1.26
2.63
4.4
4.3
—
—
—
0
0
188
1511
1.30
2.61
1.9
1.7
421.98
32211600.07
pmol/l
1.48
166
1307
8
20
4.02
2.57
2.4
1.1
—
—
—
0
0
237
1967
1.27
2.56
3.0
2.8
—
—
—
0
0
173
1379
1.31
2.56
3.2
3.6
0.82
0.82
mmol/l
0.14
166
1328
43
262
1.67
2.55
2.2
2.6
—
—
—
0
0
532
4823
1.22
2.51
5.7
5.3
6.80
6.65
mmol/l
0.84
499
4571
32
180
1.80
2.50
1.1
1.1
23.54
1.84
u/ml
0.69
19
90
891
8561
1.36
2.48
15.4
14.0
21.47
23.23
mg/l
0.84
745
6921
14
57
2.48
2.45
1.1
1.0
1630.86
1537.11
miu/ml
0.10
14
57
39
235
1.69
2.42
1.1
1.1
10.20
2.45
u/ml
1.03
23
130
291
2498
1.23
2.31
6.2
6.5
—
—
—
0
0
9
28
3.23
2.31
1.3
1.6
—
—
—
0
0
899
8666
1.35
2.30
5.0
4.7
1.35
1.41
mmol/l
4.78
839
8219
71
499
1.45
2.28
3.4
3.8
4.69
4.72
pmol/l
0.11
61
452
13
53
2.47
2.28
1.2
1.2
—
—
—
0
0
501
4544
1.20
2.27
7.4
6.8
2.05
1.94
e9/l
0.30
458
4030
142
1124
1.31
2.22
1.3
1.2
—
—
—
0
0
11
41
2.70
2.21
37.8
31.4
136.55
125.38
ug/l
0.19
11
32
397
3531
1.21
2.19
13.5
11.5
1.22
1.18
inr
0.93
336
2910
602
5566
1.20
2.18
4.6
4.0
—
3.45
—
0
9
536
4909
1.20
2.13
10.0
10.4
4.08
4.04
e9/l
0.16
485
4284
27
153
1.79
2.09
1.2
1.1
—
—
—
0
0
27
153
1.79
2.09
2.6
3.9
4.21
4.22
e9/l
0.01
27
153
16
75
2.15
2.09
1.4
1.6
71.36
61.09
%
0.80
11
55
83
613
1.39
2.05
1.2
1.2
123.69
136.92
u/ml
0.12
27
247
27
154
1.77
2.05
1.1
1.4
0.87
0.33
nmol/l
0.48
18
125
388
3462
1.20
2.04
8.4
7.0
1.21
1.21
mmol/l
0.84
363
3232
136
1085
1.29
2.01
8.6
6.5
1.05
1.03
mmol/l
0.23
129
1025
133
1061
1.29
1.97
1.3
1.3
—
—
—
0
0
70
506
1.41
1.97
2.6
2.9
261.99
155.42
ng/l
0.39
61
455
850
8166
1.27
1.96
5.1
4.6
6.00
5.89
mmol/l
1.39
798
7642
486
4435
1.19
1.95
7.5
6.8
0.04
0.04
e9/l
0.88
440
3845
899
8699
1.32
1.95
5.1
4.8
4.63
4.71
mmol/l
1.80
842
8285
207
1743
1.24
1.95
2.9
2.6
4.43
5.07
e6/l
0.38
191
1586
10
39
2.58
1.94
1.1
1.5
—
—
—
0
0
297
2598
1.20
1.91
3.6
3.2
18.37
74.98
e6/l
1.46
222
1950
973
9547
1.60
1.89
24.0
21.1
252.53
250.79
e9/l
0.39
958
9406
247
2125
1.22
1.89
1.8
1.6
19.47
19.61
nmol/l
0.06
219
1845
484
4425
1.18
1.88
7.6
6.8
0.58
0.57
e9/l
0.17
439
3837
7
22
3.20
1.88
1.0
1.5
—
—
—
0
0
551
5093
1.18
1.88
4.7
4.1
115.62
1315.04
e6/l
—
8
69
140
1132
1.28
1.87
1.7
1.4
—
—
—
0
0
93
712
1.34
1.86
5.4
4.8
0.38
0.66
%
1.22
29
209
328
2905
1.19
1.84
3.8
4.3
1.48
1.89
ug/l
1.78
302
2685
94
723
1.33
1.82
5.6
5.5
0.00
0.14
%
2.21
26
174
973
9554
1.58
1.79
23.9
21.0
90.34
90.52
fl
0.65
965
9490
92
708
1.33
1.78
5.7
5.2
0.00
0.13
%
5.13
25
192
973
9556
1.57
1.76
23.9
21.0
30.22
30.31
pg
0.88
965
9491
973
9556
1.57
1.76
24.4
21.5
41.49
42.34
%
0.68
965
9483
973
9556
1.57
1.76
23.9
21.0
4.63
4.63
e12/l
0.01
957
9391
27
162
1.69
1.76
3.4
2.5
91.26
90.45
%
0.33
27
157
973
9558
1.57
1.73
24.0
21.1
6.70
6.63
e9/l
0.43
957
9388
476
4368
1.17
1.72
6.5
7.0
11.22
11.71
umol/l
0.53
451
4193
69
511
1.38
1.72
4.3
3.4
7.41
7.42
ph
0.36
61
436
41
275
1.51
1.71
4.2
2.4
25.11
24.75
mmol/l
0.27
41
275
973
9560
1.56
1.71
24.1
21.2
139.15
139.45
g/l
0.25
966
9494
336
3000
1.18
1.69
4.4
3.8
117.38
83.73
e6/l
0.23
237
2087
156
1295
1.24
1.68
3.2
2.9
1.91
2.06
e6/l
0.13
72
601
413
3759
1.17
1.63
2.0
1.9
1.53
1.45
mmol/l
0.75
349
3284
95
747
1.30
1.60
5.6
5.1
0.54
1.06
%
1.55
27
231
8
32
2.51
1.60
5.0
3.1
0.62
0.61
mmol/l
—
8
32
27
167
1.63
1.59
1.1
1.1
14.36
3.67
u/ml
1.21
16
74
256
2246
1.19
1.58
3.2
3.1
0.46
0.41
e6/l
0.11
182
1606
50
356
1.43
1.57
2.0
2.2
—
—
—
0
0
775
7425
1.19
1.55
19.4
17.2
13.46
13.45
%
0.02
767
7342
361
3262
1.17
1.55
2.1
2.1
—
—
—
0
0
177
1503
1.22
1.55
3.0
2.7
531.44
547.13
mosm/kgh2o
0.41
156
1309
15
78
1.94
1.54
1.2
1.3
39990.25
80303.35
e6/l
—
8
55
14
71
1.99
1.54
1.1
1.0
3.06
1.12
u/ml
—
8
27
442
4059
1.16
1.53
7.6
6.9
3.03
2.90
%
0.58
426
3834
425
3894
1.16
1.51
9.4
7.5
1.22
1.21
mmol/l
1.22
374
3417
83
648
1.31
1.49
1.3
1.3
1550.68
204.80
u/ml
2.16
75
606
853
8257
1.22
1.46
4.3
4.0
1.45
1.34
mmol/l
3.33
792
7775
440
4051
1.15
1.45
7.6
7.0
0.71
0.69
%
0.37
424
3823
336
3033
1.16
1.45
3.2
3.4
40.99
58.57
ng/l
0.31
207
1956
7
151
0.46
1.44
1.9
1.2
—
—
—
0
0
6
22
2.74
1.43
3.5
1.8
4.00
3.56
mmol/l
—
6
17
446
4114
1.15
1.43
7.2
6.8
56.77
56.88
%
0.07
436
3960
171
1461
1.21
1.41
2.6
3.0
2.44
2.43
mmol/l
0.32
149
1315
440
4058
1.15
1.40
7.6
7.1
8.91
8.80
%
0.40
423
3839
9
40
2.26
1.40
1.8
3.7
15.42
17.79
%
—
9
40
24
150
1.61
1.39
1.0
1.0
7.25
0.52
u/ml
—
8
55
51
375
1.38
1.37
1.4
1.4
8.14
7.20
u/l
0.30
44
312
216
1891
1.18
1.36
1.6
1.5
2.69
2.43
g/l
1.10
141
1237
452
4185
1.15
1.35
7.5
6.9
28.16
28.27
%
0.07
439
3996
14
75
1.88
1.34
4.9
4.1
—
—
—
0
0
147
1245
1.21
1.33
3.0
2.6
2.38
2.35
g/l
0.32
136
1164
300
2702
1.16
1.32
3.2
3.5
2.36
2.35
mmol/l
0.53
277
2491
30
201
1.51
1.31
1.1
1.1
7.73
1.65
u/ml
0.58
15
88
243
2158
1.17
1.28
4.4
4.2
91.88
92.22
%
0.08
236
2122
30
202
1.50
1.28
1.1
1.1
8.47
1.85
u/ml
1.32
20
105
136
1148
1.21
1.28
3.0
2.6
22.03
24.01
%
1.15
129
1078
51
380
1.36
1.28
1.7
1.6
284.22
268.87
mu/l
0.15
46
350
490
4576
1.14
1.26
7.8
7.2
0.21
0.19
e9/l
1.48
445
4025
16
92
1.75
1.25
4.1
2.6
1.03
1.39
g/24h
—
10
63
230
2039
1.17
1.24
2.9
3.3
1318.79
926.68
ng/l
0.84
191
1694
177
1536
1.18
1.24
4.0
3.9
305.98
632.28
ng/l
1.14
131
1125
31
213
1.47
1.21
1.1
1.1
12.11
6.14
u/ml
0.68
22
123
16
93
1.73
1.21
4.1
2.2
31.94
33.14
pg
0.39
16
93
22
140
1.58
1.21
1.4
1.5
—
—
—
0
0
22
141
1.57
1.18
1.1
1.2
—
—
—
0
0
102
846
1.23
1.15
3.0
3.1
1.80
1.78
%
0.07
92
773
8
39
2.06
1.15
4.5
4.7
—
—
—
0
0
220
1957
1.16
1.14
1.7
1.8
1.35
1.09
mg/l
0.42
170
1491
31
432
0.71
1.10
1.3
3.1
—
—
—
0
0
29
202
1.45
1.08
1.4
1.6
3688.06
18294.89
e6/l
1.78
18
145
78
635
1.25
1.06
3.9
3.1
75.37
71.93
e9/l
0.41
52
457
28
195
1.45
1.05
2.8
3.7
57.29
58.11
%
0.12
28
195
137
1182
1.18
1.04
2.3
2.4
13.43
14.24
nmol/l
0.70
124
1113
16
98
1.64
1.03
1.3
1.4
20.69
26.84
ng/l
0.58
16
98
15
91
1.66
1.01
5.5
2.1
0.98
0.86
%
—
9
59
339
3132
1.12
0.99
3.6
3.5
33.33
33.64
u/l
0.03
323
2975
9
49
1.84
0.98
1.3
3.2
7.39
8.09
mmol/l
—
9
49
14
84
1.68
0.98
1.0
1.1
—
—
—
0
0
21
140
1.51
0.98
1.4
1.3
—
—
—
0
0
473
4457
1.12
0.98
3.8
3.5
0.00
0.37
estimate
0.52
96
833
126
1088
1.18
0.96
3.1
3.3
4.00
5.10
e9/l
1.25
111
971
58
463
1.27
0.94
1.3
1.4
28.03
23.27
iu/l
0.51
47
399
11
62
1.78
0.94
1.7
1.3
—
—
—
0
0
11
62
1.78
0.94
1.2
1.2
—
—
—
0
0
23
158
1.47
0.94
1.4
1.3
—
—
—
0
0
7
37
1.90
0.94
1.4
1.4
6.32
6.38
mmol/l
—
7
37
470
4436
1.11
0.93
3.8
3.5
16.34
7.16
estimate
0.23
106
901
40
305
1.32
0.92
1.4
1.8
—
—
—
0
0
17
110
1.55
0.91
1.8
2.6
—
—
—
0
0
139
1218
1.16
0.90
3.0
2.7
148.50
124.15
ug/g
0.43
117
1005
88
742
1.20
0.88
3.0
2.8
10.42
10.57
g/l
0.16
81
692
71
586
1.23
0.88
2.5
1.8
1.44
1.32
g/l
0.13
61
550
8
43
1.87
0.87
2.3
1.7
—
—
—
0
0
39
502
0.77
0.86
1.3
2.1
—
—
—
0
0
25
179
1.41
0.84
2.4
2.4
27.21
109.57
ug/min
1.88
15
111
235
2145
1.12
0.84
1.3
1.3
2.40
1.73
u/ml
0.22
80
619
116
1011
1.17
0.81
3.5
2.9
10.58
8.23
umol/l
0.42
109
905
22
155
1.43
0.81
1.4
1.9
0.88
0.80
g/l
0.17
17
127
45
356
1.28
0.81
5.4
3.4
—
—
—
0
0
43
540
0.79
0.80
1.7
1.7
0.27
0.33
mg/l
0.55
17
283
19
270
0.70
0.80
1.5
2.9
—
—
—
0
0
6
33
1.82
0.79
3.8
2.4
64544.50
690.12
e6/l
—
6
26
0
27
0.00
0.77
0.0
1.4
—
11.32
—
0
21
113
988
1.16
0.77
1.6
1.6
—
—
—
0
0
51
623
0.81
0.75
1.3
2.2
—
—
—
0
0
230
2111
1.12
0.75
5.5
5.0
—
—
—
0
0
13
83
1.57
0.75
1.2
1.4
—
—
—
0
0
12
75
1.61
0.75
1.0
1.0
—
—
—
0
0
61
506
1.22
0.75
1.3
1.2
0.90
0.93
g/l
0.37
61
506
157
1410
1.13
0.74
2.8
2.8
0.74
0.98
e6/l
0.48
74
724
52
630
0.82
0.72
1.3
2.1
—
—
—
0
0
11
68
1.62
0.72
2.0
1.7
—
—
—
0
0
82
704
1.18
0.71
2.1
2.1
0.04
0.03
estimate
0.11
23
167
141
1262
1.14
0.70
1.3
1.4
507.27
478.13
titre
0.08
22
256
7
41
1.71
0.70
2.0
1.9
77.17
100.02
ng/l
—
7
41
52
627
0.82
0.69
1.3
2.2
—
—
—
0
0
7
42
1.67
0.68
1.1
1.1
—
—
—
0
0
66
558
1.20
0.68
4.2
4.4
1.23
1.23
mmol/l
0.86
55
481
266
2474
1.10
0.68
2.3
2.2
209.64
207.59
u/l
0.02
259
2375
27
205
1.33
0.67
4.3
3.7
1.40
2.39
ratio
1.24
16
116
460
4389
1.09
0.67
3.7
3.4
0.00
0.00
estimate
0.50
102
891
105
925
1.15
0.66
8.8
9.2
7.41
7.41
ph
0.01
56
502
52
624
0.82
0.66
1.3
2.0
—
—
—
0
0
11
70
1.58
0.65
1.1
1.1
—
—
—
0
0
11
70
1.58
0.65
1.3
1.2
—
—
—
0
0
7
44
1.59
0.65
2.9
1.6
27.86
27.23
umol/l
—
7
39
15
103
1.46
0.65
1.2
1.2
—
—
—
0
0
31
393
0.78
0.65
1.8
1.6
1024.64
990.81
mu/l
0.06
25
329
24
181
1.33
0.63
1.0
1.1
—
—
—
0
0
56
471
1.20
0.62
1.1
1.1
0.69
0.70
ratio
—
8
46
31
244
1.28
0.61
1.1
1.1
—
—
—
0
0
5
30
1.67
0.61
1.2
1.9
34.36
41.64
g/l
—
5
30
5
30
1.67
0.61
2.2
2.0
15.40
6.53
%
—
5
30
19
139
1.37
0.60
3.6
1.7
—
—
—
0
0
29
227
1.29
0.60
4.6
4.0
45.80
75.01
mg/l
0.52
24
192
58
493
1.19
0.59
1.1
1.1
1.45
1.48
g/l
0.58
58
493
49
582
0.83
0.58
1.2
2.2
—
—
—
0
0
103
917
1.14
0.58
8.7
9.1
2.10
0.85
mmol/l
3.06
83
783
37
302
1.23
0.56
1.2
1.3
—
—
—
0
0
35
284
1.24
0.56
3.8
4.0
312.83
321.40
mg/l
0.03
24
131
10
65
1.54
0.55
1.1
1.0
—
—
—
0
0
6
38
1.58
0.54
1.0
1.9
—
—
—
0
0
22
169
1.31
0.53
1.2
1.1
2.80
16.72
au/ml
—
6
59
9
63
1.43
0.52
1.2
1.5
—
—
—
0
0
55
472
1.17
0.51
2.9
2.6
—
—
—
0
0
6
40
1.50
0.51
1.0
1.1
—
—
—
0
0
103
927
1.12
0.50
8.9
9.0
12.18
12.59
kpa
0.39
98
903
74
652
1.15
0.50
3.6
3.5
—
—
—
0
0
6
41
1.47
0.50
3.3
1.5
2.00
1.96
umol/l
—
6
34
31
252
1.24
0.50
1.1
1.3
781.23
482.08
mg/l
0.52
31
241
41
344
1.20
0.49
1.2
1.3
—
—
—
0
0
95
853
1.13
0.49
2.4
2.1
368.37
370.33
nmol/l
0.03
86
811
13
178
0.73
0.49
1.3
1.3
—
—
—
0
0
28
226
1.25
0.48
1.7
1.5
—
—
—
0
0
7
46
1.53
0.48
2.1
4.3
447.14
721.07
u/ml
—
7
46
11
76
1.45
0.48
1.1
1.1
—
—
—
0
0
19
244
0.77
0.47
9.8
9.9
—
—
—
0
0
81
722
1.13
0.47
1.2
1.2
—
—
—
0
0
7
48
1.46
0.47
1.4
1.2
—
—
—
0
0
89
800
1.12
0.46
4.4
3.8
1.63
1.86
mmol/l
0.20
79
701
8
121
0.66
0.45
1.0
1.5
—
0.44
nmol/l
—
0
7
24
192
1.26
0.45
1.1
1.1
—
—
—
0
0
46
395
1.17
0.44
2.3
2.1
0.00
1.79
estimate
0.50
17
140
245
2317
1.08
0.44
4.1
3.7
0.00
0.01
estimate
1.34
94
834
26
211
1.24
0.44
1.4
1.5
144.87
152.68
au/ml
—
9
64
19
148
1.29
0.43
1.8
2.7
—
9.60
—
0
5
178
1665
1.08
0.42
1.8
1.7
—
—
—
0
0
5
32
1.57
0.42
2.4
1.9
30.60
31.06
%
—
5
32
10
70
1.43
0.41
20.6
13.2
0.59
0.63
mmol/l
—
10
65
0
15
0.00
0.41
0.0
1.2
—
1.80
—
0
15
665
6508
1.06
0.41
4.0
3.5
44.61
47.87
u/l
0.73
632
6240
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.40
0.0
5.5
—
8.25
—
0
17
0
17
0.00
0.40
0.0
2.6
—
33.36
—
0
17
5
34
1.47
0.40
1.0
1.3
27.20
27.44
s
—
5
34
7
101
0.69
0.39
1.6
2.9
—
—
—
0
0
5
35
1.43
0.39
1.2
1.5
0.66
0.48
e9/l
—
5
35
7
106
0.66
0.39
1.0
1.5
—
—
nmol/l
—
0
0
0
19
0.00
0.39
0.0
1.2
—
339.67
—
0
12
41
354
1.16
0.38
1.5
1.3
301.07
232.33
miu/ml
0.40
15
170
11
80
1.38
0.38
4.3
5.5
47.03
48.30
u/ml
—
6
30
141
1313
1.09
0.38
1.8
1.7
—
—
—
0
0
39
451
0.86
0.38
3.7
2.7
0.56
0.63
%
0.60
39
451
38
327
1.17
0.37
1.4
1.7
8.53
9.34
u/ml
—
7
87
9
69
1.31
0.37
1.0
1.2
—
—
—
0
0
8
116
0.69
0.37
1.0
1.5
0.51
0.60
nmol/l
—
8
111
15
189
0.79
0.34
2.1
2.7
1.50
1.51
mmol/l
0.02
15
184
41
361
1.14
0.31
2.3
1.8
32.36
6.58
iu/ml
—
9
82
35
305
1.15
0.31
3.5
4.0
68.28
1185.50
u/ml
1.42
29
263
370
3585
1.05
0.31
3.1
3.1
6.20
6.16
ph
0.28
200
2116
20
166
1.21
0.30
2.7
3.6
—
—
—
0
0
15
185
0.81
0.30
1.9
1.6
—
—
—
0
0
265
2549
1.05
0.29
3.4
2.8
0.05
0.04
estimate
0.02
87
725
96
893
1.08
0.29
1.4
1.5
—
—
—
0
0
12
94
1.28
0.28
1.2
1.2
—
67.54
—
0
5
8
63
1.27
0.27
3.5
3.2
1597.87
1035.49
mg
—
8
63
90
837
1.08
0.27
4.8
3.8
7.38
7.38
ph
0.30
56
494
24
205
1.17
0.27
1.2
1.5
—
—
—
0
0
8
64
1.25
0.27
2.1
1.3
—
—
—
0
0
38
338
1.13
0.26
1.7
2.2
20.41
20.94
s
0.38
32
310
24
206
1.17
0.26
1.7
1.8
—
—
—
0
0
37
329
1.13
0.26
2.3
2.5
2740.88
5634.27
u/l
0.57
12
138
773
7640
1.05
0.26
19.5
17.5
333.66
334.07
g/l
0.53
766
7610
107
1005
1.07
0.26
1.4
1.4
—
—
—
0
0
30
263
1.15
0.26
1.1
1.1
—
—
—
0
0
15
179
0.84
0.23
1.8
1.5
—
—
—
0
0
5
39
1.28
0.23
1.2
1.2
0.00
0.00
estimate
—
5
39
32
285
1.13
0.23
1.8
2.1
387.23
308.33
ug/l
0.17
32
273
62
669
0.92
0.22
1.4
1.4
—
—
—
0
0
7
95
0.74
0.22
1.0
1.1
—
—
—
0
0
33
367
0.90
0.21
1.1
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
3.8
—
0.20
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
45.60
—
0
12
0
12
0.00
0.21
0.0
2.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
0.12
—
0
6
101
1066
0.94
0.21
2.0
1.9
—
—
—
0
0
123
1290
0.95
0.21
1.5
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
0.02
—
0
14
42
384
1.10
0.20
1.2
1.3
—
—
—
0
0
84
792
1.07
0.20
3.3
2.4
0.22
0.22
g/l
0.29
78
756
15
127
1.18
0.19
1.7
1.9
—
—
—
0
0
52
561
0.92
0.19
4.2
3.2
—
—
—
0
0
11
90
1.22
0.19
1.0
1.0
307.64
283.51
mg/l
0.57
11
82
79
745
1.07
0.19
10.8
10.0
—
—
—
0
0
155
1491
1.05
0.19
1.3
1.3
16.62
12.33
u/ml
0.26
63
595
6
53
1.13
0.18
1.0
1.1
1.12
1.06
ratio
—
6
47
29
261
1.11
0.18
1.1
1.1
4.67
6.25
eliau/ml
—
7
38
7
58
1.21
0.18
1.0
1.2
7.14
9.22
mm/h
—
7
58
405
3974
1.03
0.18
3.2
2.9
—
—
—
0
0
218
2117
1.04
0.17
1.9
2.0
—
—
—
0
0
6
76
0.79
0.15
2.0
1.7
—
—
—
0
0
6
78
0.77
0.15
1.0
1.8
—
—
—
0
0
10
83
1.21
0.15
3.7
7.8
6.93
6.92
mmol/l
—
10
73
9
78
1.16
0.15
3.9
2.5
—
—
—
0
0
13
112
1.16
0.14
1.2
1.4
145.91
178.52
pmol/l
0.52
13
112
81
773
1.05
0.14
8.6
8.7
1.54
1.37
mmol/l
0.34
81
765
53
501
1.06
0.13
9.7
11.4
24.77
24.22
mmol/l
0.53
53
496
64
609
1.05
0.13
1.1
1.1
—
—
—
0
0
167
1626
1.03
0.12
1.3
1.3
28.81
29.56
iu/ml
0.03
49
481
52
549
0.94
0.12
1.3
1.2
—
—
—
0
0
25
229
1.09
0.12
2.7
2.1
3.17
4.31
iu/l
0.63
11
99
10
85
1.18
0.12
1.9
2.3
37.48
36.77
%
—
10
85
28
303
0.92
0.12
1.4
1.3
—
1566.67
—
0
6
257
2618
0.98
0.11
1.5
1.5
—
—
—
0
0
11
126
0.87
0.11
1.5
1.8
—
—
—
0
0
14
157
0.89
0.11
1.3
1.2
2.14
4.82
u/ml
—
7
76
205
2010
1.02
0.10
2.3
2.4
—
—
—
0
0
59
614
0.96
0.09
2.1
2.3
6.82
8.45
ug/l
0.41
51
559
6
54
1.11
0.09
1.2
1.1
324.00
411.68
nmol/l
—
6
47
45
471
0.95
0.08
1.3
1.2
—
—
—
0
0
16
146
1.10
0.08
1.3
3.9
12.74
8.56
pmol/l
0.27
16
146
30
283
1.06
0.08
1.2
1.1
—
—
—
0
0
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
7
65
1.08
0.08
1.0
1.3
—
—
—
0
0
14
127
1.10
0.08
1.6
2.3
—
1760.00
—
0
9
25
235
1.07
0.07
1.9
1.6
—
—
—
0
0
10
112
0.89
0.07
1.4
1.6
—
—
—
0
0
87
848
1.03
0.07
2.6
2.9
39.47
95.12
u/l
0.50
74
742
108
1057
1.02
0.06
1.4
1.4
—
—
—
0
0
27
284
0.95
0.06
1.3
1.3
—
—
—
0
0
13
141
0.92
0.05
1.3
1.2
—
—
—
0
0
176
1783
0.98
0.05
2.6
2.8
0.74
0.69
ug/l
0.23
84
970
73
713
1.03
0.05
4.1
4.9
7.36
26.50
ug/l
0.94
60
585
339
3414
0.99
0.04
3.8
3.3
0.01
0.02
estimate
0.19
83
754
130
1316
0.99
0.03
2.3
2.0
3.64
3.68
ratio
0.16
100
1033
26
250
1.04
0.03
1.6
1.5
331.31
284.27
ug/g
0.35
15
147
66
672
0.98
0.03
5.4
4.5
7.33
7.35
ph
0.31
51
505
52
509
1.02
0.03
1.5
1.7
—
—
—
0
0
23
239
0.96
0.02
1.4
1.3
272.56
238.15
u/ml
0.24
16
147
13
122
1.07
0.02
1.2
1.2
—
—
—
0
0
10
93
1.08
0.02
1.1
1.1
—
—
—
0
0
384
3852
0.99
0.01
2.9
2.8
—
—
estimate
—
0
0
61
618
0.99
0.01
2.3
2.2
6.05
6.06
ph
0.05
44
391
24
233
1.03
0.01
1.1
1.1
—
—
—
0
0
100
992
1.01
0.01
2.0
1.7
3.52
3.54
mmol/l
0.09
69
695
10
94
1.06
0.01
1.8
2.1
—
—
—
0
0
15
156
0.96
0.00
1.9
3.7
—
—
—
0
0
264
2647
1.00
0.00
2.5
2.4
—
—
—
0
0
24
234
1.03
0.00
1.1
1.1
—
—
—
0
0
10
96
1.04
0.00
11.9
17.5
855.00
808.69
nmol/l
—
10
91
11
108
1.02
0.00
1.4
1.8
—
—
—
0
0
22
223
0.99
0.00
4.0
3.4
7.33
2.16
index
—
9
130
10
101
0.99
0.00
3.3
2.5
8.98
11.03
%
—
10
101
11
109
1.01
0.00
2.0
2.3
—
—
—
0
0
122
1223
1.00
0.00
1.3
1.4
—
—
—
0
0
17
165
1.03
0.00
1.2
1.4
62.78
102.04
pmol/l
0.84
17
160
11
115
0.96
0.00
1.4
1.6
—
—
—
0
0
11
115
0.96
0.00
1.4
1.6
—
—
—
0
0
11
115
0.96
0.00
1.4
1.6
—
—
—
0
0
11
115
0.96
0.00
1.4
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
582.44
—
0
5
9
96
0.94
-0.00
1.1
1.4
—
—
—
0
0
197
1970
1.00
-0.00
4.0
3.5
1.02
1.02
kg/l
0.06
136
1283
0
5
0.00
-0.00
0.0
1.2
—
34.52
—
0
5
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
67.50
—
0
8
8
79
1.01
-0.00
2.6
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
0.16
—
0
6
15
150
1.00
-0.00
1.1
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
154.00
—
0
6
0
5
0.00
-0.00
0.0
3.4
—
1.38
—
0
5
0
7
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
74
0.95
-0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.03
—
0
7
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
—
—
0
0
6
65
0.92
-0.00
1.2
1.4
80.50
76.65
umol/l
—
6
65
7
71
0.99
-0.00
1.0
1.2
110.57
110.72
pmol/l
—
7
71
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.8
—
105.60
—
0
5
7
74
0.95
-0.00
1.1
1.8
10.29
11.88
umol/l
—
7
69
7
72
0.97
-0.00
1.1
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
178.67
—
0
6
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CORNEALDEFORM and mortality.

Females

Parameter HR [95% CI] p-value
H7_CORNEALDEFORM 1.128 [0.92, 1.38] 0.242
Birth year 0.996 [0.99, 1.0] 0.321

During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 1933 females with H7_CORNEALDEFORM died.

Males

Parameter HR [95% CI] p-value
H7_CORNEALDEFORM 1.021 [0.86, 1.21] 0.808
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 189 out of 4002 males with H7_CORNEALDEFORM died.

Mortality risk

Mortality risk for people of age

years, who have H7_CORNEALDEFORM.

N-year risk Females Males
1 0.109% 0.207%
5 0.733% 1.187%
10 1.729% 2.947%
15 3.295% 5.608%
20 5.82% 9.48%

Relationships between endpoints

↥

Index endpoint: H7_CORNEALDEFORM – Keratoconus

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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