Pre-eclampsia superimposed on chronic hypertension

O15_PREECLAMPS_CHRONIC_HYPERT

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O11
  • Cause of death: ICD-10 O11

2 out of 7 registries used, show all original rules.

233

4. Check minimum number of events

None

233

5. Include endpoints

None

233

6. Filter based on genotype QC (FinnGen only)

209

Control definitions (FinnGen only)

Control exclude
O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O10-O16
Name in latin
Hypertensio prae-existens cum proteinuria superposita

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1336 1336 -
Only index persons 1325 1325 -
Unadjusted period prevalence (%)
Whole population 0.04 0.04 -
Only index persons 0.05 0.05 -
Median age at first event (years)
Whole population - 32.55 -
Only index persons - 32.55 -

-FinnGen-

Key figures

All Female Male
Number of individuals 209 209 -
Unadjusted period prevalence (%) 0.07 0.07 -
Median age at first event (years) 33.15 33.15 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
215
Matched controls
2150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O11
ICD-10 Finland
Pre-eclampsia superimposed on chronic hypertension
+∞
311.3
215
*
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
+∞
137.8
117
*
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1876.6
114.6
101
*
205
Kela drug reimbursment
Chronic hypertension
19.4
71.2
62
44
C09AA02
ATC
enalapril; systemic
16.2
70.1
69
61
I10
ICD-10 Finland
Essential (primary) hypertension
11.3
65.4
161
449
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
+∞
55.7
51
*
C07AG01
ATC
labetalol; systemic
183.5
54.8
55
*
C08CA05
ATC
nifedipine; systemic
20.0
50.0
41
25
C08CA01
ATC
amlodipine; oral
7.5
46.7
96
209
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
5.8
37.1
112
338
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
391.6
33.9
33
*
C07AB02
ATC
metoprolol; systemic
6.4
29.8
60
123
O14.1
ICD-10 Finland
Severe pre-eclampsia
+∞
28.8
27
*
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
4.8
27.7
90
278
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
4.9
27.6
89
273
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
5.3
26.0
67
170
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
10.7
25.0
29
31
K85
ICPC
Elevated blood pressure
5.7
21.0
45
96
103
Kela drug reimbursment
Diabetes, insulin-treated
4.4
20.5
64
187
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.4
19.7
63
187
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
8.0
18.7
27
38
C07AB07
ATC
bisoprolol; oral
3.5
18.1
98
414
C09CA03
ATC
valsartan; oral
7.7
16.9
25
36
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
3.6
16.5
72
262
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.6
16.2
28
48
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.1
15.4
29
54
A10AB05
ATC
insulin aspart; parenteral
6.2
15.2
28
51
A10AC01
ATC
insulin (human); parenteral
4.7
14.9
38
93
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
3.0
14.5
111
558
O60
ICD-10 Finland
Preterm labour and delivery
6.0
14.4
27
50
C09CA01
ATC
losartan; oral
3.8
14.4
53
171
A10BJ06
ATC
semaglutide; parenteral
5.9
14.1
27
51
A10AB04
ATC
insulin lispro; parenteral
6.8
14.0
23
37
A10BA02
ATC
metformin; oral
3.3
13.3
63
238
A10AE04
ATC
insulin glargine; parenteral
5.0
13.1
30
67
C09AA05
ATC
ramipril; oral
4.4
13.0
36
94
O10.9
ICD-10 Finland
Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium
+∞
12.6
12
*
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
3.5
12.4
50
170
W84
ICPC
Pregnancy high risk
4.5
12.2
32
80
C09DA06
ATC
candesartan and diuretics; oral
6.4
12.0
21
36
C09BA02
ATC
enalapril and diuretics; systemic
15.9
12.0
19
13
E66.01
ICD-10 Finland
Obesity due to excess calories
3.3
11.8
55
205
E66.8
ICD-10 Finland
Other obesity
3.8
11.3
39
119
O82.0
ICD-10 Finland
Delivery by elective caesarean section
3.8
11.2
38
115
T89
ICPC
Diabetes insulin dependent
5.7
10.8
21
40
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
4.5
10.8
28
69
E66.00
ICD-10 Finland
Metabolic syndrome
5.2
10.8
23
48
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
2.6
10.5
103
564
O10.1
ICD-10 Finland
Pre-existing hypertensive heart disease complicating pregnancy, childbirth and the puerperium
+∞
10.5
10
*
B01AB05
ATC
enoxaparin; parenteral
2.7
10.5
74
345
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
14.1
10.4
17
13
C09DA01
ATC
losartan and diuretics; oral
4.9
10.0
23
51
C08CA13
ATC
lercanidipine; oral
4.5
9.7
25
61
T90
ICPC
Diabetes non-insulin dependent
3.2
9.7
44
160
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.2
9.6
43
155
A10BH01
ATC
sitagliptin; oral
5.1
9.5
21
45
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.1
9.3
20
42
C03AA03
ATC
hydrochlorothiazide; oral
8.6
9.1
19
24
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
3.2
9.0
39
138
SPAT1262
SPAT
Handing over of treatment supplies
3.3
8.9
36
122
K86
ICPC
Hypertension uncomplicated
4.9
8.8
20
44
A10AB01
ATC
insulin (human); parenteral
6.9
8.7
21
33
C09DA03
ATC
valsartan and diuretics; oral
12.3
8.7
15
13
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
7.9
8.7
19
26
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.2
8.7
38
135
O24.9
ICD-10 Finland
Diabetes mellitus in pregnancy, unspecified
4.8
8.6
20
45
A10AE05
ATC
insulin detemir; parenteral
5.2
8.5
18
37
C09CA06
ATC
candesartan; oral
2.6
8.4
64
306
O16
ICD-10 Finland
Unspecified maternal hypertension
+∞
8.4
8
*
6420X
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Benign essential hypertension complicating pregnancy, childbirth and the puerperium
+∞
8.4
8
*
OAB50, ,
SPAT
4.9
8.3
19
42
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
34.8
8.1
10
*
H04AA01
ATC
glucagon; nasal, parenteral
7.9
7.8
17
23
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
15.8
7.8
12
8
MAA00
NOMESCO Finland
Amniocentesis
4.4
7.7
20
49
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
4.0
7.7
23
63
C10AA05
ATC
atorvastatin; oral
2.6
7.7
51
227
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.5
7.5
61
299
E66.9
ICD-10 Finland
Obesity, unspecified
4.1
7.5
21
55
WX320
NOMESCO Finland
Spinalanesthesy
2.4
7.0
61
308
XMA22
NOMESCO Finland
General examination of pregnant woman
2.6
6.9
46
204
C10AA07
ATC
rosuvastatin; oral
2.3
6.9
64
331
ZXD05
NOMESCO Finland
Urgent procedure
2.2
6.9
93
561
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
9.8
6.9
13
14
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
4.0
6.8
20
54
H3603, E103,
ICD-10 Finland
23.4
6.7
9
*
A10BK01
ATC
dapagliflozin; oral
4.1
6.7
19
50
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.6
6.5
42
184
C07AB08
ATC
celiprolol; oral
71.9
6.5
7
*
C02EA02, ,
ATC
+∞
6.3
6
*
6424A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, ENNEN SYNNYTYSTÄ]
+∞
6.3
6
*
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.0
6.2
29
106
J01DB01
ATC
cefalexin; oral
3.3
6.2
196
1633
A10BK03
ATC
empagliflozin; oral
3.6
6.2
21
63
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
3.3
6.1
24
79
MAC96
NOMESCO Finland
Other induction or advancement of labour
3.4
6.1
22
69
SPAT1263
SPAT
Sampling
2.0
6.0
96
609
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.7
6.0
36
151
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
2.0
6.0
126
882

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
110
347
5.44
34.10
7.6
3.4
33.83
6.15
mg/mmol
2.05
88
201
109
346
5.36
33.42
6.6
2.9
122.28
36.24
mg/l
2.45
88
214
117
435
4.71
28.46
6.2
2.6
7.64
7.98
mmol/l
0.37
105
385
12
7
18.04
8.17
3.5
1.9
3823.58
723.00
mg
—
12
7
90
521
2.25
7.54
9.5
5.7
1.07
1.04
inr
0.33
73
432
127
891
2.04
6.03
6.1
3.7
7.42
6.11
mmol/l
4.45
116
815
47
228
2.36
5.79
3.4
2.1
2.45
2.47
g/l
0.09
42
215
108
724
1.99
5.74
9.0
5.1
1.21
1.21
mmol/l
0.50
94
637
40
183
2.46
5.60
2.8
1.8
29.17
29.53
s
0.17
40
177
76
454
2.04
5.56
2.3
1.7
1.02
0.76
mg/l
0.38
55
342
48
247
2.21
5.12
1.2
1.3
93.65
157.49
u/ml
1.08
23
114
45
239
2.12
4.40
3.4
2.8
0.89
0.83
mmol/l
0.44
45
229
108
789
1.74
3.89
2.2
1.7
1.56
1.36
mmol/l
1.43
93
735
19
74
2.72
3.66
16.4
5.3
—
—
—
0
0
73
486
1.76
3.58
2.8
2.5
12.89
272.41
ng/l
0.53
37
162
163
1368
1.79
3.32
8.7
6.9
74.56
72.03
u/l
0.50
155
1308
14
49
2.99
3.26
11.3
1.9
22.71
23.97
mmol/l
1.04
14
49
13
45
3.01
3.08
3.0
3.1
—
—
—
0
0
12
37
3.37
2.98
2.8
2.9
853.57
266.43
mg/l
—
7
14
93
689
1.62
2.95
2.1
2.0
107.69
98.22
pmol/l
0.99
59
400
9
22
4.22
2.91
1.0
1.2
—
—
—
0
0
85
618
1.62
2.90
3.4
1.9
—
—
—
0
0
105
804
1.60
2.88
3.2
2.7
5.95
6.20
ph
1.66
62
484
77
547
1.64
2.88
1.9
1.7
—
—
—
0
0
63
432
1.65
2.68
7.1
3.1
7.40
7.40
ph
0.08
45
300
12
41
3.04
2.67
1.8
1.5
—
—
—
0
0
5
7
7.28
2.56
1.0
1.0
179.20
177.38
mmol/24h
—
5
7
113
897
1.55
2.56
3.3
2.5
—
—
estimate
—
0
0
19
90
2.22
2.47
11.1
2.4
7.29
7.39
ph
—
8
47
58
398
1.63
2.44
4.1
2.3
0.53
0.28
e6/l
0.25
37
275
193
1762
1.93
2.28
4.8
3.3
1.43
1.17
mmol/l
5.65
185
1692
35
213
1.77
2.28
2.7
1.9
—
—
—
0
0
64
457
1.57
2.27
2.8
1.9
—
—
—
0
0
7
18
3.98
2.27
5.3
1.8
67.14
63.22
%
—
7
18
9
29
3.19
2.25
1.1
1.1
—
—
nmol/l
—
0
0
33
203
1.74
2.08
2.5
1.4
—
—
—
0
0
31
188
1.76
2.05
1.5
1.6
1042.57
1129.19
nmol/l
0.23
23
151
184
1673
1.69
1.98
6.2
5.0
14.34
14.14
pmol/l
0.53
178
1619
10
39
2.64
1.97
1.1
1.1
—
—
—
0
0
6
16
3.83
1.95
3.7
2.7
39.53
13.57
mu/l
—
6
16
7
22
3.25
1.89
1.6
1.3
16.66
22.99
ng/l
—
7
22
120
1005
1.44
1.87
4.2
3.1
0.00
0.00
estimate
-0.00
27
195
63
467
1.49
1.85
2.3
2.1
3.01
2.51
mg/l
1.02
56
405
5
12
4.24
1.83
1.8
1.6
52.80
88.75
nmol/24h
—
5
12
119
998
1.43
1.82
4.2
3.0
0.00
14.36
estimate
0.80
27
203
24
140
1.80
1.81
1.5
1.4
—
—
—
0
0
63
470
1.48
1.79
4.1
2.4
21.97
76.39
e6/l
0.94
43
347
24
141
1.79
1.77
1.5
1.4
—
—
—
0
0
24
141
1.79
1.77
1.5
1.4
—
—
—
0
0
23
134
1.80
1.74
1.6
1.4
—
—
—
0
0
117
985
1.41
1.71
4.2
3.0
0.00
0.00
estimate
0.50
27
201
23
135
1.79
1.70
1.1
1.1
—
—
—
0
0
43
299
1.55
1.69
1.9
2.1
—
—
—
0
0
8
31
2.64
1.67
1.6
1.3
0.50
1.55
ug/l
—
8
26
24
144
1.75
1.66
5.0
2.8
—
—
—
0
0
201
1893
1.95
1.64
6.5
4.1
2.89
2.91
mmol/l
0.08
192
1842
32
209
1.62
1.63
1.7
2.7
3.43
4.94
umol/l
3.11
23
184
23
139
1.73
1.56
1.6
1.4
—
—
—
0
0
43
307
1.50
1.50
1.3
1.4
421.41
425.03
pmol/l
0.04
37
284
199
1876
1.82
1.50
5.9
3.8
1.35
1.55
mmol/l
12.84
192
1823
24
149
1.69
1.48
2.9
4.6
1.54
1.04
%
0.25
13
37
7
28
2.55
1.46
1.4
1.1
—
—
—
0
0
17
96
1.84
1.43
10.1
6.6
7.44
7.41
ph
—
8
59
199
1881
1.78
1.41
5.9
3.9
4.68
4.87
mmol/l
2.50
193
1835
23
144
1.67
1.39
2.9
4.4
0.46
1.09
%
0.78
13
33
23
144
1.67
1.39
2.6
5.1
0.00
0.26
%
0.59
12
27
36
252
1.51
1.38
4.3
2.7
3294.50
221.53
ng/l
0.44
18
108
75
603
1.37
1.38
3.3
2.3
0.00
0.04
estimate
1.15
25
162
9
43
2.14
1.32
2.0
4.8
—
—
—
0
0
42
308
1.45
1.29
3.5
2.2
9.63
11.10
e6/l
0.15
35
278
38
275
1.46
1.25
1.6
1.5
794.14
1065.81
mu/l
1.25
30
209
76
622
1.34
1.23
5.0
3.0
21.31
29.64
e6/l
0.36
48
386
11
57
1.98
1.19
4.5
4.8
23.96
24.79
mmol/l
0.59
11
57
5
20
2.53
1.15
2.2
4.2
3.76
3.62
mmol/l
—
5
20
12
66
1.87
1.11
1.6
1.2
—
—
—
0
0
12
66
1.87
1.11
1.1
1.5
—
—
—
0
0
74
612
1.32
1.10
7.0
5.8
—
—
—
0
0
201
1923
1.69
1.10
16.3
10.6
16.11
16.36
mg/l
0.05
180
1489
73
604
1.32
1.08
2.9
2.5
—
0.00
—
0
7
43
328
1.39
1.07
1.8
1.4
—
—
—
0
0
26
181
1.50
1.04
3.9
2.4
31.30
33.49
u/l
0.12
20
152
5
22
2.30
1.04
1.2
1.5
—
—
—
0
0
9
47
1.95
1.03
14.2
7.8
1.43
1.21
%
—
9
47
9
47
1.95
1.03
15.8
7.8
0.62
0.68
%
—
9
47
9
48
1.91
1.02
15.8
7.7
95.94
94.61
%
—
9
48
9
49
1.87
1.00
10.9
2.0
0.53
0.61
%
—
9
49
62
507
1.31
0.99
4.6
2.9
0.00
0.01
estimate
0.80
26
199
20
133
1.56
0.98
15.7
5.1
104.90
104.99
mmol/l
0.02
20
133
54
434
1.33
0.97
1.9
1.5
16.35
21.19
nmol/l
1.96
47
401
9
51
1.80
0.96
10.9
2.0
1.31
1.45
%
—
9
51
21
143
1.52
0.94
3.0
4.7
0.00
0.16
%
—
10
31
79
673
1.27
0.92
2.0
2.0
—
—
—
0
0
10
56
1.82
0.89
1.1
1.2
—
—
—
0
0
186
1768
1.39
0.86
5.5
3.7
5.97
5.53
mmol/l
4.58
173
1702
30
226
1.38
0.82
1.7
1.3
—
—
—
0
0
40
316
1.33
0.81
4.6
3.0
—
—
—
0
0
88
769
1.24
0.81
3.9
2.7
0.00
0.07
estimate
1.39
25
168
52
427
1.29
0.80
3.8
2.8
1.02
1.02
kg/l
0.41
36
284
29
218
1.38
0.80
3.6
2.2
4.20
4.58
e6/l
—
10
93
14
90
1.59
0.80
2.3
2.4
2.04
4.35
iu/l
—
7
37
0
25
0.00
0.79
0.0
18.8
—
959.08
—
0
25
0
27
0.00
0.78
0.0
22.4
—
1730.74
—
0
27
11
171
0.62
0.76
1.1
1.2
—
—
—
0
0
46
375
1.29
0.75
1.6
1.4
1200.00
503.59
titre
—
10
78
45
544
0.78
0.74
3.2
4.1
—
—
—
0
0
5
25
2.02
0.73
2.2
2.1
7.40
7.43
ph
—
5
25
5
25
2.02
0.73
2.2
4.4
1.42
1.35
mmol/l
—
5
25
14
93
1.54
0.71
1.4
1.5
0.30
0.27
mg/l
—
6
34
12
180
0.65
0.71
1.3
1.8
—
—
—
0
0
18
248
0.70
0.70
1.8
1.8
—
—
—
0
0
62
531
1.24
0.68
1.3
1.4
14.50
20.82
iu/ml
0.77
22
157
50
418
1.26
0.67
4.0
3.2
—
—
—
0
0
17
120
1.45
0.67
1.6
1.4
—
—
—
0
0
5
29
1.74
0.64
1.0
1.1
—
—
—
0
0
14
96
1.49
0.63
3.2
3.0
—
—
—
0
0
5
30
1.68
0.62
1.0
1.2
—
—
—
0
0
70
614
1.21
0.61
1.7
1.3
0.58
2.43
u/ml
1.37
21
166
8
52
1.56
0.60
7.1
6.9
—
—
—
0
0
22
167
1.35
0.59
1.5
1.5
43.46
60.77
ug/l
1.69
17
131
6
35
1.73
0.58
3.2
2.0
—
—
—
0
0
54
464
1.22
0.57
1.6
1.7
—
—
—
0
0
20
151
1.36
0.56
1.8
1.7
0.00
0.11
estimate
—
5
45
6
40
1.51
0.52
1.0
1.2
—
—
—
0
0
9
65
1.40
0.51
1.3
1.6
—
—
—
0
0
38
324
1.21
0.44
1.5
1.3
—
—
—
0
0
8
57
1.42
0.42
2.1
2.9
50.88
78.71
ng/l
—
8
51
8
57
1.42
0.42
1.1
2.3
—
—
—
0
0
55
490
1.16
0.40
1.3
1.3
8.21
9.04
u/ml
0.05
28
198
5
35
1.44
0.39
2.0
1.3
—
—
—
0
0
172
1773
0.85
0.38
21.6
14.0
331.47
331.82
g/l
0.20
172
1764
62
560
1.15
0.38
5.0
6.1
—
—
—
0
0
96
895
1.13
0.36
2.1
1.9
—
—
—
0
0
33
285
1.19
0.35
4.1
2.2
561.43
528.67
mosm/kgh2o
0.39
28
254
11
82
1.36
0.35
2.0
1.2
1.40
1.86
u/ml
—
5
5
6
46
1.31
0.33
1.0
1.3
—
—
—
0
0
205
2018
1.34
0.33
17.6
9.5
—
—
—
0
0
72
664
1.13
0.32
2.0
1.6
—
—
—
0
0
12
93
1.31
0.30
1.6
1.2
—
—
—
0
0
58
530
1.13
0.30
1.7
1.4
2.56
2.06
g/l
1.45
39
338
5
75
0.66
0.26
1.0
1.1
—
—
—
0
0
99
939
1.10
0.26
2.9
2.4
—
—
—
0
0
5
39
1.29
0.23
14.2
3.4
36.94
36.96
°c
—
5
39
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
1.18
—
0
10
0
12
0.00
0.21
0.0
1.8
—
155.08
—
0
12
0
12
0.00
0.21
0.0
2.2
—
1.19
—
0
12
0
12
0.00
0.21
0.0
2.2
—
105.33
—
0
12
0
12
0.00
0.21
0.0
2.2
—
3.91
—
0
12
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
109.95
—
0
13
6
50
1.21
0.20
1.0
1.7
—
—
—
0
0
7
58
1.21
0.18
1.3
1.3
—
—
—
0
0
25
278
0.89
0.18
2.0
1.7
3.72
3.42
mmol/l
0.57
14
180
16
138
1.17
0.18
1.7
1.4
1.31
1.28
mm
—
10
92
82
858
0.93
0.18
12.8
8.5
0.00
0.00
e9/l
0.78
65
686
13
152
0.85
0.17
1.0
1.1
0.95
0.87
g/l
0.63
13
152
176
1729
1.10
0.17
19.8
13.3
13.47
13.32
%
0.75
176
1717
16
139
1.16
0.17
1.7
1.4
—
—
—
0
0
24
216
1.13
0.16
1.5
1.4
—
—
—
0
0
12
102
1.19
0.15
2.1
1.6
—
—
—
0
0
13
150
0.86
0.15
1.0
1.1
1.50
1.64
g/l
1.46
13
150
25
228
1.11
0.14
1.3
1.2
—
—
—
0
0
20
180
1.12
0.13
1.8
2.0
25.58
39.47
u/ml
0.39
20
173
29
269
1.09
0.12
1.3
1.2
—
—
—
0
0
22
201
1.11
0.12
1.3
1.4
—
—
—
0
0
16
144
1.12
0.10
1.7
1.5
—
—
—
0
0
31
329
0.93
0.09
2.6
2.5
107.12
71.97
ug/g
0.54
26
264
15
136
1.11
0.09
1.0
1.1
—
—
—
0
0
13
144
0.90
0.08
1.0
1.1
—
0.63
—
0
7
7
85
0.82
0.07
1.4
1.7
—
—
—
0
0
9
104
0.86
0.06
1.3
4.0
2.62
9.29
ug/l
—
9
74
103
1014
1.03
0.05
6.3
6.2
0.04
0.04
e9/l
0.19
89
892
12
130
0.92
0.04
1.3
1.2
205.14
258.45
miu/ml
—
7
70
12
130
0.92
0.04
1.3
1.3
—
—
—
0
0
22
229
0.96
0.03
1.2
1.4
—
—
—
0
0
23
222
1.04
0.02
2.8
2.1
913.58
3316.00
u/l
—
9
91
96
951
1.02
0.02
6.6
5.8
28.09
29.53
%
0.79
90
911
105
1058
0.99
0.01
6.4
6.6
0.22
0.17
e9/l
1.71
95
949
92
927
0.99
0.01
6.8
5.9
2.85
2.75
%
0.16
85
876
102
1013
1.01
0.01
6.4
6.2
0.56
0.51
e9/l
1.32
88
894
14
134
1.05
0.00
1.4
1.1
—
121.67
—
0
6
112
1126
0.99
0.00
8.5
9.4
4.46
3.92
e9/l
1.48
98
986
14
136
1.03
0.00
1.9
1.4
—
—
—
0
0
44
441
1.00
0.00
1.5
1.4
—
—
—
0
0
93
926
1.01
0.00
6.8
5.9
0.61
0.71
%
1.21
86
865
14
137
1.02
0.00
2.1
2.0
6.61
6.20
ph
—
9
79
95
945
1.01
0.00
6.3
5.8
57.73
56.76
%
0.38
88
905
92
925
0.99
0.00
6.8
5.9
7.68
8.01
%
0.54
86
875
26
262
0.99
0.00
1.2
1.1
—
—
—
0
0
17
168
1.01
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.4
—
7.46
—
0
5
0
5
0.00
0.00
0.0
1.8
—
14.80
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
0.03
—
0
8
6
63
0.95
-0.00
1.7
2.1
—
—
—
0
0
6
69
0.87
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
69
0.87
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
104
1040
1.00
-0.00
6.4
6.2
2.06
1.98
e9/l
0.35
94
938
0
8
0.00
-0.00
0.0
1.0
—
87.13
—
0
8
0
7
0.00
-0.00
0.0
3.3
—
8.45
—
0
7

Mortality – FinRegistry

Association

Association between endpoint O15_PREECLAMPS_CHRONIC_HYPERT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PREECLAMPS_CHRONIC_HYPERT.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_PREECLAMPS_CHRONIC_HYPERT – Pre-eclampsia superimposed on chronic hypertension

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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