obsolete_cleft palate: ['Congenital fissure of the soft and/or hard palate, due to faulty fusion.']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditions
|
556897 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
426 |
4. Check minimum number of eventsNone |
426 |
5. Include endpointsNone |
426 |
6. Filter based on genotype QC (FinnGen only) |
389 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CLEFT_LIP_CLEFT_PALATE
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Cleft palate
based on the number of shared cases.
Similar with more cases:
- Cleft lip, lip and palate or palate
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5369 | 3001 | 2360 |
| Only index persons | 4471 | 2522 | 1949 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.07 |
| Only index persons | 0.08 | 0.09 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 1.83 | 1.71 | 1.86 |
| Only index persons | 1.89 | 1.81 | 1.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 389 | 268 | 121 |
| Unadjusted period prevalence (%) | 0.08 | 0.10 | 0.06 |
| Median age at first event (years) | 2.70 | 2.05 | 4.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 402
- Matched controls
- 4020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q35.1
ICD-10 Finland
Cleft hard palate
3351.5
205.7
181
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
+∞
193.9
170
*
4122
FHL
Tympanostomy (tympanic tube)
20.6
118.7
98
62
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
+∞
90.1
83
*
4364
FHL
Pharyngeal tongue plastic
+∞
77.7
72
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
15.5
76.2
71
55
4362
FHL
Nozzle reconstruction
+∞
65.4
61
*
Q35.71
ICD-10 Finland
Submucous cleft palate
618.8
56.0
54
*
Q35.9
ICD-10 Finland
Cleft palate, unspecified
592.3
53.8
52
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
+∞
53.3
50
*
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
9.1
52.7
71
93
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
16.9
51.0
44
29
EB1MA
NOMESCO Finland
Cephalometry with X-ray
9.7
50.7
64
77
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
7.8
48.1
74
113
SAA04
NOMESCO Finland
Special examination of mouth
7.4
46.8
76
123
7490C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS SUBMUCOSAE]
+∞
43.5
41
*
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
+∞
42.5
40
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
7.7
41.2
63
95
H65.3
ICD-10 Finland
Chronic mucoid otitis media
8.5
40.9
57
77
SBB10
NOMESCO Finland
Dental impressions
4.8
36.1
99
258
4451
FHL
Guitar cutting
6.0
34.7
68
132
K00.00
ICD-10 Finland
Hypodontia
12.3
31.3
32
28
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
+∞
26.3
25
*
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
+∞
26.3
25
*
Q35.3
ICD-10 Finland
Cleft soft palate
277.5
26.0
26
*
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
5.9
25.6
49
92
4361
FHL
Lip plastic or reconstruction due to cleft lip
+∞
25.3
24
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.1
24.7
46
84
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
6.0
23.4
44
81
UDC00
NOMESCO Finland
Ear microscopy
4.8
23.4
58
137
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
6.2
23.4
42
74
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
+∞
23.1
22
*
4368
FHL
Closing the fistula of the mouth
+∞
22.1
21
*
1450
FHL
Otomicroscopy
23.9
20.7
29
13
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
6.2
20.6
37
65
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
20.1
20.3
30
16
EAB30
NOMESCO Finland
Correction of cleft lip
+∞
20.0
19
*
EBB10
NOMESCO Finland
Insertion of dental implant
17.9
19.5
30
18
EHC40
NOMESCO Finland
Repair of submucous cleft palate
198.9
18.7
19
*
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
5.9
17.7
33
60
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
187.9
17.7
18
*
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
14.8
17.6
29
21
EEC05
NOMESCO Finland
Le Fort I osteotomy
66.3
16.9
19
*
ECB17
NOMESCO Finland
Operation of gingival cleft
+∞
16.8
16
*
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
7.3
16.7
25
36
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
6.9
16.4
26
40
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
+∞
15.7
15
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.0
14.7
74
281
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
11.0
14.5
27
26
EBB15
NOMESCO Finland
Insertion of dental implant abutment
28.4
14.4
19
7
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
23.3
14.4
20
9
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.8
14.0
85
357
74929
ICD-8 Finland
Cleft palate and cleft lip, Unspecified
+∞
13.6
13
*
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
41.6
13.2
16
*
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
5.2
12.8
27
55
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.4
12.7
48
153
4365
FHL
Correction of nasal deformity
+∞
12.6
12
*
4367
FHL
Bone transfer to the upper jaw
+∞
12.6
12
*
H66.9
ICD-10 Finland
Otitis media, unspecified
2.8
12.5
71
287
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
4.2
12.5
34
86
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
27.7
12.1
16
6
DCD00
NOMESCO Finland
Myringoplasty
19.7
11.7
17
9
ZSZ10
NOMESCO Finland
Secondary repair operation
67.0
11.7
13
*
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
11.5
11
*
74924
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis bilateralis
+∞
11.5
11
*
Q35.70
ICD-10 Finland
Cleft uvula
+∞
11.5
11
*
ZXB10
NOMESCO Finland
Medial
17.7
11.3
17
10
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
28.9
10.8
14
5
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
61.7
10.7
12
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
61.7
10.7
12
*
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
10.5
10.6
20
20
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
3.9
10.5
32
88
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.2
10.4
44
150
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
11.0
10.4
19
18
SPC20
NOMESCO Finland
Implant borne crown
19.4
10.3
15
8
H74.1
ICD-10 Finland
Adhesive middle ear disease
41.2
10.0
12
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
17.2
9.9
15
9
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
9.8
147
893
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
15.5
9.6
15
10
Q35
ICD-10 Finland
Cleft palate
102.3
9.5
10
*
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
30.8
9.5
12
*
EHC30
NOMESCO Finland
Reconstruction of palate
+∞
9.4
9
*
Q36.9
ICD-10 Finland
Cleft lip, unilateral
+∞
9.4
9
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.6
9.2
31
91
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
37.6
9.1
11
*
ZXA10
NOMESCO Finland
Bilateral
2.4
9.0
71
334
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
8.9
166
1079
DFF00
NOMESCO Finland
Pure tone audiometry
3.0
8.8
40
142
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
8.7
207
1454
R1260
NOMESCO Finland
Evaluation of communicative skills
10.4
8.6
16
16
SPF10
NOMESCO Finland
Demanding reparation of dental prosthesis
28.2
8.5
11
*
K07.14
ICD-10 Finland
Retrognaty, maxillary
20.6
8.5
12
6
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
20.6
8.5
12
6
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
4.1
8.5
23
58
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
4.8
8.4
19
41
Q35.7
ICD-10 Finland
Cleft uvula
+∞
8.4
8
*
DLW00
NOMESCO Finland
Correction of cleft nose
+∞
8.4
8
*
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
3.9
8.3
25
68
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
8.3
194
1349
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
3.8
8.1
25
69
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
6.5
8.1
20
32
J01DA08
ATC
[U] cefaclor
2.2
8.1
82
428
H04
ICPC
Ear discharge
4.6
8.0
19
43
H65.2
ICD-10 Finland
Chronic serous otitis media
7.2
7.9
18
26
S02CA02
ATC
flumetasone and antiinfectives; otic
3.6
7.8
26
76
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
18.8
7.6
11
6
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
25.6
7.6
10
*
SPF20
NOMESCO Finland
Temporary relining of dentures
25.6
7.6
10
*
Z2221
NOMESCO Finland
Medical doctor
1.9
7.5
126
784
9808
FHL
Bone graft
81.5
7.4
8
*
4347
FHL
Osteotomy of the upper jaw
81.5
7.4
8
*
R49.2
ICD-10 Finland
Hypernasality and hyponasality
81.5
7.4
8
*
74912
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis unilateralis
+∞
7.3
7
*
Q37.99
ICD-10 Finland
Cleft palate with cleft lip NOS
+∞
7.3
7
*
K01.0
ICD-10 Finland
Embedded teeth
4.1
7.2
20
51
H65.0
ICD-10 Finland
Acute serous otitis media
4.6
7.2
17
38
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
3.6
6.8
22
63
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
12.5
6.6
11
9
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.8
6.6
33
124
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
3.1
6.6
28
96
ZZG00
NOMESCO Finland
Graft of cartilage
70.9
6.4
7
*
4741B
ICD-9 Finland
Chronic disease of tonsils and adenoids, Hypertrophy of tonsils and adenoids[HYPERTROPHIA TONSILLAE PHARYNGICAE]
3.8
6.3
19
52
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
+∞
6.3
6
*
4363
FHL
Hidden slit reconstruction
+∞
6.3
6
*
Q37.3
ICD-10 Finland
Cleft soft palate with unilateral cleft lip
+∞
6.3
6
*
EH1JB
NOMESCO Finland
Functional examination of palate
+∞
6.3
6
*
Q37.90
ICD-10 Finland
Unspecified cheft palate with cleft lip, unilateral
+∞
6.3
6
*
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
27.1
6.2
8
*
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
3.0
6.2
27
94
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.7
6.2
144
980
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
3.9
6.2
18
48
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
8.8
6.1
12
14
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
3.6
6.1
20
58
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
13
49
2.71
2.65
1.4
1.3
—
—
—
0
0
14
58
2.46
2.39
1.1
1.4
—
—
—
0
0
50
328
1.60
2.33
8.0
9.8
104.90
104.60
mmol/l
0.21
50
328
8
28
2.89
1.87
1.1
1.1
1514.25
1590.14
miu/ml
—
8
28
36
232
1.61
1.83
9.0
13.4
1.84
0.60
mmol/l
1.33
29
189
8
31
2.61
1.66
1.1
1.2
—
—
—
0
0
111
1340
0.76
1.64
1.8
1.8
1.32
1.35
mmol/l
0.13
102
1207
7
26
2.72
1.58
1.1
2.6
—
0.79
—
0
10
7
27
2.62
1.52
1.0
3.9
—
—
—
0
0
14
72
1.98
1.50
4.2
3.0
2.50
2.90
index
—
6
40
18
107
1.71
1.28
6.6
4.7
55.71
50.58
%
0.43
18
107
6
25
2.42
1.25
1.0
1.1
—
—
—
0
0
23
148
1.59
1.23
12.2
14.6
1.46
1.37
%
0.14
23
148
6
26
2.33
1.19
1.0
1.2
—
—
—
0
0
6
26
2.33
1.19
3.8
1.6
10.50
10.81
mmol/l
—
6
26
13
219
0.58
1.13
1.6
1.7
0.53
0.29
mg/l
—
6
96
50
641
0.75
1.12
1.3
1.3
16.54
8.35
u/ml
0.33
23
258
22
144
1.56
1.11
12.4
15.0
0.74
0.67
%
0.38
22
144
22
146
1.54
1.05
12.6
14.8
96.03
94.17
%
1.93
22
146
135
1183
1.21
1.03
5.3
5.6
36.93
37.62
g/l
0.75
130
1131
7
35
2.02
1.00
1.1
1.4
—
—
—
0
0
25
176
1.45
0.93
1.8
1.8
—
—
—
0
0
84
985
0.81
0.92
2.1
2.2
—
—
—
0
0
92
1065
0.82
0.88
2.3
2.3
—
—
—
0
0
314
3269
0.82
0.87
3.8
3.9
1.46
1.45
mmol/l
0.25
304
3146
23
319
0.70
0.86
1.6
1.6
66.59
62.03
ug/l
0.21
17
268
14
88
1.61
0.85
1.3
1.3
—
—
—
0
0
8
45
1.79
0.84
1.0
1.0
—
—
—
0
0
45
561
0.78
0.84
1.8
2.0
—
—
—
0
0
316
3284
0.82
0.83
3.9
4.0
4.79
4.70
mmol/l
0.97
305
3166
11
65
1.71
0.83
1.9
1.5
—
—
—
0
0
193
1774
1.17
0.82
5.1
5.7
6.18
6.32
mmol/l
0.49
173
1612
6
32
1.89
0.82
2.0
1.6
0.57
0.48
e9/l
—
6
32
94
815
1.20
0.80
3.0
3.2
0.66
0.21
e6/l
0.74
74
570
0
24
0.00
0.79
0.0
1.0
—
101.53
—
0
17
0
24
0.00
0.79
0.0
3.4
—
639.29
—
0
24
0
24
0.00
0.79
0.0
1.0
—
93.53
—
0
17
6
33
1.83
0.79
1.2
1.4
—
—
—
0
0
6
33
1.83
0.79
1.2
1.4
—
—
—
0
0
6
33
1.83
0.79
1.2
1.4
—
—
—
0
0
26
191
1.39
0.79
2.8
5.5
1.04
0.90
mmol/l
0.09
17
136
13
197
0.65
0.77
1.2
1.5
—
—
—
0
0
13
83
1.59
0.76
1.4
1.5
439.17
289.37
ug/g
—
6
42
318
3295
0.83
0.75
4.1
4.2
2.93
2.84
mmol/l
1.21
306
3166
10
60
1.68
0.72
2.3
5.5
366.30
371.70
umol/l
—
10
53
28
212
1.34
0.72
1.1
1.1
1.52
1.52
g/l
0.02
28
212
209
1952
1.15
0.68
3.4
3.3
69.45
79.46
ug/l
0.81
199
1874
5
94
0.53
0.67
1.2
1.8
—
—
—
0
0
28
215
1.32
0.67
1.1
1.1
0.98
0.89
g/l
1.06
28
215
340
3295
1.21
0.67
12.3
12.1
139.52
139.58
mmol/l
0.16
330
3226
368
3597
1.27
0.65
13.5
13.0
71.33
69.56
umol/l
0.32
363
3556
146
1336
1.15
0.63
8.3
8.4
1.21
1.22
mmol/l
0.34
133
1173
51
427
1.22
0.63
2.9
2.5
2.42
2.42
g/l
0.02
46
395
61
709
0.84
0.62
1.3
1.3
20.05
22.68
iu/ml
0.14
18
206
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.6
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
6
35
1.72
0.58
1.2
1.4
—
—
—
0
0
6
35
1.72
0.58
1.2
1.4
—
—
—
0
0
19
141
1.36
0.57
1.1
1.1
0.80
9.22
eliau/ml
—
5
26
12
172
0.69
0.57
1.2
1.2
15.05
3.63
u/ml
—
6
98
129
1179
1.14
0.57
7.7
8.1
1.20
1.22
mmol/l
0.93
120
1102
5
86
0.58
0.57
1.2
1.5
—
—
—
0
0
6
38
1.59
0.54
1.2
1.3
—
—
—
0
0
18
134
1.36
0.54
1.5
1.3
—
—
—
0
0
61
699
0.85
0.53
2.9
2.9
326.59
322.00
umol/l
0.15
56
658
23
292
0.77
0.53
1.7
1.5
—
—
—
0
0
46
537
0.84
0.50
1.6
1.6
1139.22
973.05
mu/l
0.36
36
456
151
1404
1.12
0.50
4.0
3.1
0.00
0.03
estimate
1.22
33
317
7
108
0.64
0.49
1.1
1.2
—
—
—
0
0
7
108
0.64
0.49
1.1
1.2
—
—
—
0
0
7
109
0.64
0.49
1.7
2.1
—
—
—
0
0
7
45
1.57
0.49
1.0
1.5
—
—
—
0
0
391
3866
1.42
0.48
18.8
18.1
270.80
261.62
e9/l
2.08
384
3817
338
3298
1.16
0.47
12.6
12.1
3.93
3.92
mmol/l
0.50
326
3217
56
489
1.17
0.46
2.7
3.2
332.03
584.83
ng/l
0.27
31
269
24
297
0.80
0.46
1.6
1.5
0.90
0.98
ratio
0.68
12
188
24
297
0.80
0.46
1.6
1.5
1.20
1.19
ratio
0.02
12
188
24
297
0.80
0.46
1.6
1.5
1.00
1.19
ratio
0.59
12
188
51
585
0.85
0.46
2.3
1.8
1.40
1.36
%
0.13
45
540
125
1157
1.12
0.44
1.7
1.9
102.64
96.92
pmol/l
0.73
67
632
13
95
1.38
0.44
1.3
1.9
—
—
—
0
0
391
3869
1.39
0.43
18.7
18.1
4.59
4.59
e12/l
0.11
384
3815
15
195
0.76
0.42
1.4
1.8
2.59
3.33
mg/l
—
9
131
60
674
0.87
0.42
2.0
2.2
—
—
—
0
0
192
1823
1.10
0.42
4.1
3.3
0.00
0.00
estimate
0.50
36
372
195
1853
1.10
0.42
4.1
3.4
0.00
0.01
estimate
0.50
37
351
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
2.9
—
123.50
—
0
16
28
232
1.22
0.41
12.3
12.3
1.30
1.35
mmol/l
0.10
28
226
21
168
1.26
0.41
1.4
1.4
—
—
—
0
0
194
1845
1.10
0.41
4.1
3.4
0.00
7.90
estimate
0.80
39
369
7
101
0.69
0.40
1.6
1.9
—
—
—
0
0
64
712
0.88
0.39
1.8
1.5
18.08
20.49
nmol/l
0.89
57
639
38
327
1.18
0.39
1.6
1.5
1002.77
1190.27
nmol/l
0.76
30
261
25
300
0.82
0.38
2.6
3.3
31.70
32.30
%
0.09
20
220
17
134
1.28
0.37
7.7
6.8
0.63
0.62
%
0.05
17
134
92
849
1.11
0.35
1.6
1.6
—
—
—
0
0
42
477
0.87
0.35
2.3
2.3
2.43
2.41
mmol/l
0.49
37
423
353
3471
1.14
0.34
12.5
12.0
22.02
20.40
mg/l
0.41
295
2724
26
221
1.19
0.31
12.5
13.0
25.51
24.85
mmol/l
0.61
26
221
253
2605
0.92
0.31
3.4
3.4
32.46
35.59
u/l
0.85
245
2529
318
3114
1.10
0.31
10.1
9.9
95.20
95.84
ml/min/173m2
0.21
278
2769
12
153
0.78
0.31
1.8
2.1
37.92
40.34
u/l
0.29
12
142
16
129
1.25
0.30
2.4
4.9
3.08
3.28
g/l
0.30
16
124
315
3212
0.91
0.30
5.1
5.2
1.80
1.74
mu/l
0.48
305
3079
28
241
1.17
0.30
2.3
2.7
—
—
—
0
0
32
364
0.87
0.28
1.5
1.4
—
—
—
0
0
8
62
1.30
0.28
1.5
1.6
8.61
7.38
mmol/l
—
8
62
9
117
0.76
0.28
1.0
1.3
—
2.66
—
0
10
302
3079
0.92
0.26
3.3
3.4
1.26
1.21
mmol/l
0.53
289
2939
93
989
0.92
0.26
2.6
3.1
2.37
2.35
mmol/l
0.56
81
925
9
74
1.22
0.25
5.4
7.3
—
3425.00
—
0
8
75
804
0.92
0.25
2.2
2.0
140.74
255.87
u/l
0.77
70
771
237
2433
0.94
0.24
4.3
4.0
9.72
8.33
mm/h
1.02
229
2309
6
85
0.70
0.24
1.0
1.3
—
1.28
—
0
5
86
808
1.08
0.24
2.9
2.3
2.60
2.57
mg/l
0.05
78
705
117
1228
0.93
0.23
3.2
3.6
26.86
29.35
u/l
0.79
112
1177
33
295
1.13
0.23
1.7
1.8
—
—
—
0
0
16
189
0.84
0.23
1.6
1.5
46.98
53.28
ug/l
0.24
16
189
7
92
0.76
0.22
1.0
1.9
3.30
3.48
mmol/l
—
7
87
231
2369
0.94
0.22
7.4
7.4
87.59
77.53
u/l
0.45
221
2251
10
124
0.80
0.22
1.3
1.2
—
2.57
—
0
6
206
2001
1.06
0.21
9.3
9.9
4.26
3.89
e9/l
1.48
187
1751
0
11
0.00
0.21
0.0
1.2
—
7.62
—
0
11
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
22.83
—
0
10
8
104
0.76
0.21
1.4
1.2
—
60.77
—
0
10
0
13
0.00
0.21
0.0
3.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
3.4
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
6
50
1.20
0.20
1.3
1.4
27.73
35.20
nmol/l
—
6
40
23
203
1.14
0.19
1.6
2.0
—
—
—
0
0
6
51
1.18
0.19
6.0
4.3
7.25
6.33
pmol/l
—
6
51
286
2909
0.94
0.19
4.3
4.6
37.25
37.20
mmol/mol
0.03
273
2804
96
914
1.07
0.19
3.2
2.8
30.74
47.29
ng/l
0.34
51
410
13
109
1.20
0.19
1.5
1.7
280.62
219.01
pmol/l
1.34
13
104
33
300
1.11
0.18
1.7
1.7
—
—
—
0
0
7
60
1.17
0.18
1.9
2.3
—
—
—
0
0
363
3597
1.09
0.17
9.9
9.8
27.21
27.35
u/l
0.04
354
3535
301
3052
0.95
0.16
3.6
3.7
5.59
5.64
mmol/l
0.27
282
2884
34
370
0.91
0.16
1.1
1.3
53.19
163.49
u/ml
3.21
13
156
19
168
1.14
0.16
1.6
1.7
—
—
—
0
0
6
77
0.78
0.15
1.3
1.5
—
—
—
0
0
6
79
0.76
0.15
15.7
2.5
0.62
0.91
nmol/l
—
6
69
16
182
0.87
0.15
1.3
1.6
—
—
—
0
0
18
159
1.14
0.15
1.3
1.2
—
—
—
0
0
114
1100
1.05
0.15
3.7
2.7
0.03
0.02
estimate
0.10
32
307
29
266
1.10
0.14
4.0
5.2
—
—
—
0
0
28
257
1.10
0.13
1.3
1.4
—
—
—
0
0
87
837
1.05
0.13
3.7
3.3
1.02
1.02
kg/l
0.25
51
536
309
3056
1.05
0.12
4.0
3.9
—
—
—
0
0
162
1583
1.04
0.12
2.8
2.8
—
—
estimate
—
0
0
11
126
0.87
0.11
2.5
1.5
—
—
—
0
0
24
259
0.92
0.10
1.8
4.0
4.67
4.84
pmol/l
0.35
24
232
109
1120
0.96
0.10
1.2
1.4
0.72
2.10
u/ml
1.77
29
297
10
114
0.87
0.09
2.3
1.6
—
—
—
0
0
20
217
0.92
0.09
1.8
1.8
—
—
—
0
0
50
478
1.05
0.09
3.4
2.9
4.10
3.57
e6/l
0.15
24
216
23
247
0.93
0.09
2.2
2.0
0.73
0.68
ug/l
—
10
102
41
430
0.95
0.08
1.8
1.9
—
—
—
0
0
6
71
0.84
0.07
1.3
1.1
—
—
—
0
0
7
85
0.82
0.07
1.1
1.4
14.40
17.15
u/l
—
7
70
7
85
0.82
0.07
1.1
1.7
—
—
—
0
0
11
122
0.90
0.07
1.2
1.4
—
—
—
0
0
125
1227
1.03
0.07
1.8
1.8
—
—
—
0
0
18
193
0.93
0.06
6.3
2.1
66.08
31.83
u/ml
0.38
18
183
30
314
0.95
0.06
2.7
3.0
17.97
22.69
%
—
9
91
23
243
0.94
0.06
1.2
1.3
—
17.30
—
0
17
47
456
1.03
0.05
1.6
1.6
3.61
3.44
mmol/l
0.43
29
316
27
258
1.05
0.05
1.4
1.4
179.91
271.28
miu/ml
0.97
15
139
51
497
1.03
0.04
4.0
3.7
714.98
651.64
ng/l
0.11
42
391
277
2786
0.98
0.04
4.3
4.5
14.44
14.43
pmol/l
0.02
265
2627
78
769
1.02
0.02
1.9
2.2
0.69
1.03
mg/l
1.17
61
576
51
502
1.02
0.01
1.9
1.6
442.78
48344799.05
pmol/l
1.07
45
453
96
952
1.01
0.01
4.1
3.4
0.05
0.01
estimate
0.39
37
360
11
104
1.06
0.01
1.6
1.4
62.82
89.86
pmol/l
0.31
11
98
13
136
0.95
0.00
8.2
10.6
1.17
1.21
mg/l
0.11
13
129
13
136
0.95
0.00
2.0
2.0
7.37
6.08
ug/l
0.17
13
124
29
284
1.02
0.00
1.0
1.0
—
—
—
0
0
51
504
1.01
0.00
3.4
2.8
0.82
0.72
e6/l
0.13
25
242
80
806
0.99
0.00
2.1
2.2
—
—
—
0
0
154
1546
0.99
0.00
4.6
6.6
12.25
10.78
umol/l
0.37
144
1482
69
692
1.00
0.00
3.8
4.4
5.52
8.96
mg/mmol
0.67
45
469
17
171
0.99
0.00
2.6
4.7
184.15
9.37
ug/l
—
10
130
21
209
1.01
0.00
1.2
1.4
—
—
—
0
0
148
1478
1.00
0.00
3.1
2.8
71.80
72.56
nmol/l
0.13
141
1397
25
251
1.00
0.00
1.8
1.6
—
—
—
0
0
14
137
1.02
0.00
1.2
2.2
2.93
4.26
iu/l
—
6
57
13
135
0.96
0.00
2.0
1.5
95.00
219.82
u/ml
—
8
79
58
583
0.99
0.00
1.9
1.8
3.67
3.42
ratio
0.61
42
438
39
390
1.00
-0.00
2.2
2.3
1184.82
6497.07
u/l
2.27
18
165
6
63
0.95
-0.00
1.0
1.3
—
—
—
0
0
5
55
0.91
-0.00
1.0
3.7
61.06
5.82
u/ml
—
5
55
7
76
0.92
-0.00
1.1
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
2.69
—
0
7
7
69
1.01
-0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
9
98
0.92
-0.00
1.0
2.0
487.44
387.34
mg/l
—
9
92
0
9
0.00
-0.00
0.0
1.8
—
1.20
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_PALATE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_PALATE | 1.685 [1.24, 2.3] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1196 males with Q17_CLEFT_PALATE died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_PALATE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.31% |
| 5 | No data | 2.108% |
| 10 | No data | 4.96% |
| 15 | No data | 9.258% |
| 20 | No data | 15.23% |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_PALATE – Cleft palate
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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