cleft lip: ['Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditions
|
556897 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
661 |
4. Check minimum number of eventsNone |
661 |
5. Include endpointsNone |
661 |
6. Filter based on genotype QC (FinnGen only) |
603 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Cleft lip, lip and palate or palate
based on the number of shared cases.
Similar with more cases:
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8348 | 4172 | 4162 |
| Only index persons | 6932 | 3502 | 3430 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.12 | 0.12 |
| Only index persons | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 1.21 | 1.31 | 1.00 |
| Only index persons | 1.51 | 1.76 | 1.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 603 | 372 | 231 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.11 |
| Median age at first event (years) | 2.70 | 2.47 | 3.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 626
- Matched controls
- 6259
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q35.1
ICD-10 Finland
Cleft hard palate
2710.2
200.1
183
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
+∞
187.1
170
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
+∞
158.2
145
*
4122
FHL
Tympanostomy (tympanic tube)
16.6
125.1
112
81
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
+∞
101.9
95
*
4364
FHL
Pharyngeal tongue plastic
+∞
90.9
85
*
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
+∞
88.7
83
*
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
9.3
82.6
109
139
4362
FHL
Nozzle reconstruction
+∞
76.7
72
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
11.7
73.3
79
76
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
+∞
71.2
67
*
4361
FHL
Lip plastic or reconstruction due to cleft lip
+∞
71.2
67
*
EB1MA
NOMESCO Finland
Cephalometry with X-ray
9.2
70.9
93
117
SBB10
NOMESCO Finland
Dental impressions
5.5
69.4
165
385
SAA04
NOMESCO Finland
Special examination of mouth
7.0
68.5
117
199
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
7.4
68.0
109
173
EAB30
NOMESCO Finland
Correction of cleft lip
+∞
65.8
62
*
EBB10
NOMESCO Finland
Insertion of dental implant
19.5
65.3
52
29
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
+∞
62.6
59
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
14.5
61.2
57
43
Q35.9
ICD-10 Finland
Cleft palate, unspecified
587.3
55.5
54
*
Q35.71
ICD-10 Finland
Submucous cleft palate
587.3
55.5
54
*
K00.00
ICD-10 Finland
Hypodontia
12.5
51.3
52
45
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
20.7
50.6
39
20
74929
ICD-8 Finland
Cleft palate and cleft lip, Unspecified
+∞
48.6
46
*
1450
FHL
Otomicroscopy
20.6
47.9
37
19
H65.3
ICD-10 Finland
Chronic mucoid otitis media
7.1
47.5
76
119
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
14.3
47.2
44
33
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.6
46.7
81
138
Q36.9
ICD-10 Finland
Cleft lip, unilateral
+∞
46.4
44
*
ECB17
NOMESCO Finland
Operation of gingival cleft
+∞
45.4
43
*
4368
FHL
Closing the fistula of the mouth
+∞
44.3
42
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
6.2
43.3
80
145
7490C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS SUBMUCOSAE]
+∞
43.2
41
*
74924
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis bilateralis
+∞
42.2
40
*
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
+∞
42.2
40
*
4367
FHL
Bone transfer to the upper jaw
+∞
42.2
40
*
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
6.2
39.7
72
128
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
7.4
37.5
57
84
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
36.8
35
*
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
6.4
36.3
63
107
4365
FHL
Correction of nasal deformity
+∞
35.8
34
*
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
8.0
35.7
50
67
EEC05
NOMESCO Finland
Le Fort I osteotomy
54.7
34.9
41
8
4451
FHL
Guitar cutting
5.0
34.2
79
175
ZSZ10
NOMESCO Finland
Secondary repair operation
179.4
33.0
34
*
UDC00
NOMESCO Finland
Ear microscopy
4.5
32.7
87
216
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
4.1
30.7
94
259
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
11.2
30.7
33
31
74910
ICD-8 Finland
Cleft palate and cleft lip, Cheiloschisis unilateralis
+∞
30.5
29
*
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
5.5
30.3
62
123
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
5.9
28.7
54
99
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
7.6
27.4
40
56
DLW00
NOMESCO Finland
Correction of cleft nose
+∞
27.3
26
*
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
35.8
26.8
34
10
EBB15
NOMESCO Finland
Insertion of dental implant abutment
28.4
26.0
35
13
EHC40
NOMESCO Finland
Repair of submucous cleft palate
271.2
25.9
26
*
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
271.2
25.9
26
*
Q35.3
ICD-10 Finland
Cleft soft palate
271.2
25.9
26
*
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
9.1
25.6
32
37
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
8.1
24.9
34
44
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
4.6
22.0
55
129
74912
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis unilateralis
+∞
22.0
21
*
Q37.99
ICD-10 Finland
Cleft palate with cleft lip NOS
+∞
22.0
21
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
21.1
250
1416
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
5.5
21.1
42
81
4366
FHL
Upper jaw scar repair surgery
+∞
20.9
20
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.9
20.8
114
449
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
4.8
20.7
48
106
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
4.5
20.4
52
124
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
+∞
19.9
19
*
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
30.1
19.8
26
9
ZXB10
NOMESCO Finland
Medial
21.6
18.8
27
13
DLD20
NOMESCO Finland
Rhinoplasty
39.7
18.7
23
6
R1260
NOMESCO Finland
Evaluation of communicative skills
8.1
18.4
25
32
Z2221
NOMESCO Finland
Medical doctor
2.2
18.3
211
1169
9808
FHL
Bone graft
185.0
17.6
18
*
K07.14
ICD-10 Finland
Retrognaty, maxillary
21.6
17.4
25
12
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.5
16.7
118
525
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
7.5
16.6
24
33
ZZG00
NOMESCO Finland
Graft of cartilage
174.4
16.6
17
*
4347
FHL
Osteotomy of the upper jaw
174.4
16.6
17
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
16.1
264
1655
Q37.90
ICD-10 Finland
Unspecified cheft palate with cleft lip, unilateral
+∞
15.7
15
*
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
5.2
15.4
32
64
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
20.7
15.2
22
11
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
14.7
317
2165
SXC05
NOMESCO Finland
Other oral or dental procedure
2.7
14.6
85
343
4204
FHL
Molding of the cartilaginous part of the nose
153.4
14.5
15
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
20.6
13.9
20
10
ZSZ00
NOMESCO Finland
Primary repair operation
+∞
13.6
13
*
7491B
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS INCOMPLETA]
+∞
13.6
13
*
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
34.9
13.6
17
5
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
13.1
210
1287
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
4.2
13.0
35
87
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
19.5
13.0
19
10
SPF10
NOMESCO Finland
Demanding reparation of dental prosthesis
23.1
13.0
18
8
H66.9
ICD-10 Finland
Otitis media, unspecified
2.4
12.9
94
423
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
3.9
12.8
39
106
DCD00
NOMESCO Finland
Myringoplasty
12.6
12.7
22
18
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
32.8
12.6
16
5
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
+∞
12.5
12
*
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
24.9
12.5
17
7
SPC20
NOMESCO Finland
Implant borne crown
13.5
12.5
21
16
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
12.0
12.4
22
19
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.5
12.3
44
134
H74.1
ICD-10 Finland
Adhesive middle ear disease
27.3
12.1
16
6
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
11.9
297
2077
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
4.1
11.9
33
84
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.0
11.8
54
191
4141
FHL
Myringoplasty (also for reasons other than inflammation)
66.2
11.6
13
*
J01DA08
ATC
[U] cefaclor
2.1
11.6
119
617
Q35.70
ICD-10 Finland
Cleft uvula
+∞
11.5
11
*
Q37.3
ICD-10 Finland
Cleft soft palate with unilateral cleft lip
+∞
11.5
11
*
DFF00
NOMESCO Finland
Pure tone audiometry
2.8
11.4
60
229
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
15.4
11.4
18
12
EB1WA, ,
NOMESCO Finland
13.0
11.2
19
15
SPF20
NOMESCO Finland
Temporary relining of dentures
25.5
11.2
15
6
ZXA10
NOMESCO Finland
Bilateral
2.2
11.0
106
536
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
11.0
161
949
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
44.1
11.0
13
*
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
3.3
10.9
41
129
H65.2
ICD-10 Finland
Chronic serous otitis media
5.3
10.9
22
43
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
2.6
10.7
67
280
DLD10
NOMESCO Finland
Reconstruction of cartilage and bone of nose
61.1
10.7
12
*
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
4.9
10.6
23
48
Q35
ICD-10 Finland
Cleft palate
111.8
10.4
11
*
7491F
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOGNATOSCHISIS UNILATERALIS INCOMPLETA]
+∞
10.4
10
*
7491A
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS COMPLETA]
+∞
10.4
10
*
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
20.4
9.8
14
7
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
10.9
9.8
18
17
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
11.6
9.6
17
15
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
3.6
9.5
31
89
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
30.5
9.4
12
*
EHC30
NOMESCO Finland
Reconstruction of palate
+∞
9.4
9
*
Q36.0
ICD-10 Finland
Cleft lip, bilateral
+∞
9.4
9
*
H65.0
ICD-10 Finland
Acute serous otitis media
4.3
9.2
24
58
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
3.1
9.2
40
137
SPB20
NOMESCO Finland
Temporary bridge
15.9
9.1
14
9
4203
FHL
Mobilization and repositioning of the external pyramid
37.3
9.0
11
*
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
24.4
8.9
12
5
H04
ICPC
Ear discharge
3.9
8.9
26
69
SXC03
NOMESCO Finland
Other oral or dental procedure
10.9
8.8
16
15
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
10.9
8.8
16
15
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.9
8.8
41
147
DLD00
NOMESCO Finland
Reconstruction of cartilage of nose
50.7
8.7
10
*
SJC10
NOMESCO Finland
Orthodontic band in one tooth
3.2
8.7
35
115
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
4.3
8.5
22
53
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
8.5
75
365
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
91.2
8.4
9
*
ZXE00
NOMESCO Finland
One hour or less
1.7
8.4
237
1672
ECB60
NOMESCO Finland
Reconstruction of alveolus
+∞
8.3
8
*
Q35.7
ICD-10 Finland
Cleft uvula
+∞
8.3
8
*
Q37.8
ICD-10 Finland
Unspecified cleft palate with bilateral cleft lip
+∞
8.3
8
*
R4130
NOMESCO Finland
Speech therapy
3.6
8.2
27
78
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
3.3
8.2
30
93
SJB10
NOMESCO Finland
Fitting of removable appliance incl. patient instructions, demanding
4.5
7.9
19
43
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
6.2
7.9
20
33
ZXA05
NOMESCO Finland
Left side
1.9
7.6
107
615
ZZH22
NOMESCO Finland
Graft of patients own bone, block
18.6
7.6
11
6
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
7.5
53
234
S02CA02
ATC
flumetasone and antiinfectives; otic
3.0
7.5
32
109
R49.2
ICD-10 Finland
Hypernasality and hyponasality
81.0
7.4
8
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
7.8
7.4
16
21
SJC00
NOMESCO Finland
Bondable bracket or other fixed attachement
13.6
7.4
12
9
74913
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis bilateralis
+∞
7.3
7
*
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
7.3
7
*
H66
ICD-10 Finland
Suppurative and unspecified otitis media
3.0
7.3
32
111
J34.2
ICD-10 Finland
Deviated nasal septum
2.5
7.2
43
176
K01.0
ICD-10 Finland
Embedded teeth
3.4
7.0
25
76
SPF30
NOMESCO Finland
Relining of denture
8.4
6.9
14
17
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
3.7
6.8
21
58
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
40.5
6.8
8
*
SPD05
NOMESCO Finland
Mucosa borne complete denture, demanding
40.5
6.8
8
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
16.9
6.8
10
6
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.8
6.7
33
122
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.3
6.6
24
74
78353
ICD-8 Finland
Symptoms referable to respiratory system, Rhinolia
70.5
6.4
7
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
6.4
347
2802
SPC10
NOMESCO Finland
Standard dental crown
5.6
6.3
17
31
EBA10
NOMESCO Finland
Operative extraction of tooth
1.7
6.3
129
827
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.4
6.3
22
66
Q37.2
ICD-10 Finland
Cleft soft palate with bilateral cleft lip
+∞
6.3
6
*
EH1JB
NOMESCO Finland
Functional examination of palate
+∞
6.3
6
*
4363
FHL
Hidden slit reconstruction
+∞
6.3
6
*
4379
FHL
Other measure in this category
+∞
6.3
6
*
4305
FHL
Tooth extraction by cutting
7.1
6.2
14
20
SPF42
NOMESCO Finland
Repair of dental crown, bridge or implant structure, demanding
27.0
6.2
8
*
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
2.5
6.2
37
151
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.3
6.1
22
68
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
80
548
1.53
2.96
9.8
8.5
104.64
104.57
mmol/l
0.05
80
548
16
66
2.46
2.73
1.3
1.3
—
—
—
0
0
40
251
1.63
2.18
15.5
12.5
95.79
93.99
%
3.06
40
251
58
399
1.50
2.14
11.6
10.8
0.97
0.79
mmol/l
0.12
50
330
74
994
0.71
2.05
1.3
1.3
11.31
8.54
u/ml
0.14
35
404
19
99
1.95
1.92
1.1
1.3
—
—
—
0
0
178
1498
1.26
1.85
3.1
3.3
45.16
42.55
e6/l
0.05
142
1106
5
12
4.19
1.82
33.6
8.1
5.62
5.95
kpa
—
5
12
5
12
4.19
1.82
33.6
8.1
5.14
5.03
kpa
—
5
12
14
69
2.05
1.65
1.1
1.3
—
—
—
0
0
7
26
2.71
1.58
1.0
1.2
580.43
691.29
u/l
—
7
21
14
258
0.53
1.56
1.1
1.2
11.31
3.81
u/ml
—
8
146
120
989
1.26
1.48
2.4
2.8
8.59
7.45
e6/l
0.28
111
884
33
220
1.53
1.46
18.0
13.0
24.30
24.39
mmol/l
0.06
33
215
34
487
0.68
1.38
2.8
3.7
30.93
31.05
%
0.02
27
345
30
200
1.52
1.35
1.1
1.1
4.58
7.17
eliau/ml
—
8
35
151
1294
1.22
1.31
3.2
3.2
0.49
0.26
e6/l
0.53
116
914
59
451
1.34
1.28
9.9
6.9
1.92
1.55
mmol/l
0.32
53
384
51
385
1.35
1.21
16.6
10.3
1.21
1.30
mmol/l
0.30
51
377
60
465
1.32
1.20
8.5
6.7
5.92
5.82
kpa
0.39
60
457
10
50
2.02
1.17
1.1
3.4
—
—
—
0
0
0
33
0.00
1.16
0.0
1.0
—
—
—
0
0
9
164
0.54
1.09
1.2
1.2
—
—
—
0
0
9
165
0.54
1.09
1.2
1.2
—
—
—
0
0
8
41
1.96
1.09
1.1
1.1
1514.25
1523.80
miu/ml
—
8
41
53
412
1.31
1.06
7.9
6.5
4.81
4.80
kpa
0.01
53
406
6
125
0.47
1.05
1.3
1.6
—
—
—
0
0
303
2803
1.16
1.04
4.0
3.3
0.00
5.24
estimate
0.80
58
556
19
122
1.57
1.03
3.5
2.8
2.14
2.55
index
—
7
70
5
106
0.47
1.02
2.6
2.2
127.60
132.97
g/l
—
5
88
27
374
0.71
0.96
1.6
1.5
66.75
62.56
ug/l
0.22
19
316
0
31
0.00
0.96
0.0
1.0
—
101.53
—
0
17
0
31
0.00
0.96
0.0
1.0
—
93.53
—
0
17
10
173
0.57
0.96
1.4
1.2
—
—
—
0
0
8
143
0.55
0.94
1.1
1.7
—
—
—
0
0
92
1078
0.83
0.92
1.3
1.3
19.25
23.53
iu/ml
0.32
25
322
298
2773
1.14
0.91
3.9
3.3
0.00
0.00
estimate
0.50
56
558
303
2823
1.14
0.91
4.0
3.4
0.00
0.01
estimate
0.80
54
527
8
43
1.87
0.87
1.3
1.4
88.75
74.00
umol/l
—
8
43
115
1314
0.85
0.87
2.1
2.2
—
—
—
0
0
29
214
1.37
0.84
9.9
5.5
0.59
0.62
%
0.20
29
214
196
2145
0.87
0.83
1.9
1.9
1.36
1.39
mmol/l
0.24
179
1903
8
46
1.75
0.82
1.1
2.1
—
1.07
—
0
14
93
798
1.19
0.82
3.2
2.8
1.11
0.73
e6/l
0.70
48
392
45
357
1.28
0.81
16.3
12.1
25.06
24.94
mmol/l
0.10
45
357
29
216
1.36
0.80
2.4
3.2
76.04
103.53
ng/l
0.46
23
194
0
25
0.00
0.79
0.0
2.3
—
123.68
—
0
25
7
123
0.56
0.78
1.1
1.5
—
—
—
0
0
0
27
0.00
0.77
0.0
3.2
—
—
—
0
0
0
27
0.00
0.77
0.0
3.2
—
—
—
0
0
0
27
0.00
0.77
0.0
1.6
—
—
—
0
0
17
115
1.49
0.77
6.2
6.3
—
2572.27
—
0
11
95
823
1.18
0.76
3.7
3.3
234.91
630.98
ng/l
0.86
58
489
127
1423
0.86
0.75
2.2
2.4
—
—
—
0
0
230
2134
1.12
0.70
3.7
3.1
0.00
0.03
estimate
1.73
51
476
9
58
1.56
0.70
1.1
1.1
—
—
—
0
0
21
284
0.73
0.69
1.5
1.4
—
—
—
0
0
127
1136
1.15
0.69
1.5
1.6
—
—
—
0
0
360
3766
0.90
0.68
8.1
7.4
84.15
78.51
u/l
0.37
347
3587
501
5139
0.87
0.66
4.0
4.2
1.45
1.44
mmol/l
0.22
485
4912
7
44
1.60
0.65
1.9
1.5
0.56
0.50
e9/l
—
7
44
8
128
0.62
0.64
1.1
1.4
12.88
17.59
u/l
—
8
108
210
1951
1.11
0.62
5.5
5.4
37.00
37.36
g/l
0.44
202
1854
79
690
1.17
0.60
3.1
2.5
2.39
2.42
g/l
0.19
72
640
27
343
0.78
0.60
1.6
1.5
—
—
—
0
0
11
72
1.54
0.59
1.9
1.5
—
—
—
0
0
32
396
0.80
0.58
1.2
1.3
—
23.70
—
0
23
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
98
1.44
0.57
5.8
4.7
0.25
0.33
iu/ml
—
6
52
86
761
1.15
0.55
3.2
3.0
3.06
2.93
e6/l
0.05
41
354
28
348
0.80
0.53
1.6
1.5
0.96
1.23
ratio
0.94
13
217
28
348
0.80
0.53
1.6
1.5
1.17
1.20
ratio
0.05
13
217
28
348
0.80
0.53
1.6
1.5
0.89
0.96
ratio
0.65
13
217
23
293
0.78
0.53
1.5
1.8
2.00
3.27
mg/l
1.16
15
211
84
746
1.15
0.52
3.1
2.6
14.08
14.63
umol/l
0.27
79
700
6
97
0.61
0.52
1.3
2.1
—
—
—
0
0
508
5187
0.89
0.52
4.5
4.6
2.92
2.83
mmol/l
1.56
492
4958
505
5158
0.89
0.52
4.1
4.2
4.79
4.72
mmol/l
1.01
489
4953
61
529
1.17
0.52
1.6
1.6
914.28
1193.63
nmol/l
2.04
48
420
10
145
0.68
0.51
1.6
1.8
—
—
—
0
0
64
729
0.86
0.50
1.8
2.1
—
—
—
0
0
90
807
1.13
0.49
1.8
1.6
445.66
46345251.70
pmol/l
1.29
79
725
27
333
0.80
0.49
1.5
1.7
0.38
0.29
mg/l
0.40
13
154
7
106
0.66
0.49
1.9
2.4
—
—
—
0
0
105
1155
0.89
0.49
2.7
2.7
333.52
329.22
umol/l
0.17
96
1069
55
476
1.17
0.48
1.7
1.8
—
—
—
0
0
11
154
0.71
0.47
1.6
2.0
—
—
—
0
0
5
32
1.57
0.42
1.4
1.2
—
—
—
0
0
10
70
1.44
0.42
1.5
1.6
—
—
—
0
0
493
4829
1.10
0.41
16.1
15.0
13.34
13.28
%
0.48
486
4786
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
2.0
—
0.16
—
0
11
395
4061
0.93
0.40
3.5
3.4
39.58
39.01
u/l
0.07
383
3935
292
2805
1.08
0.39
6.2
5.3
6.37
6.41
mmol/l
0.12
265
2595
5
35
1.43
0.39
2.0
1.6
—
—
—
0
0
132
1228
1.09
0.39
2.3
2.2
—
—
—
0
0
10
136
0.73
0.38
1.1
1.6
—
—
—
0
0
57
507
1.14
0.37
3.9
2.5
37.67
30.68
u/l
1.38
48
420
55
488
1.14
0.37
1.7
1.7
—
—
—
0
0
57
637
0.88
0.36
1.5
1.6
1082.18
998.14
mu/l
0.20
45
535
40
348
1.16
0.35
1.4
1.3
263.87
250.33
miu/ml
0.08
22
175
528
5200
1.10
0.34
13.8
12.7
139.58
139.60
mmol/l
0.06
515
5092
144
1529
0.92
0.34
2.9
3.0
24.48
37.68
ng/l
0.53
77
771
135
1266
1.08
0.34
2.6
2.4
2.61
2.56
mg/l
0.08
120
1102
475
4835
0.93
0.33
3.4
3.6
1.28
1.26
mmol/l
0.36
457
4591
6
90
0.66
0.33
3.8
2.2
—
—
—
0
0
457
4657
0.93
0.32
4.9
4.9
37.73
37.60
mmol/mol
0.11
440
4471
194
1849
1.07
0.32
1.9
1.8
97.38
96.17
pmol/l
0.14
106
988
184
1753
1.07
0.31
1.8
1.8
—
—
—
0
0
26
221
1.18
0.31
1.3
1.4
—
—
—
0
0
7
100
0.70
0.30
4.0
3.6
18.86
25.56
nmol/l
—
7
94
39
344
1.14
0.30
2.7
2.5
0.24
0.40
e6/l
0.25
34
327
31
356
0.86
0.30
2.0
2.4
85.60
76.09
ml/min/173m2
—
5
150
11
141
0.78
0.29
1.0
2.1
4.57
3.62
mmol/l
0.45
11
134
7
56
1.25
0.29
2.4
1.4
—
—
—
0
0
8
108
0.74
0.29
1.1
1.5
—
—
—
0
0
152
1444
1.07
0.28
4.0
3.4
0.04
0.01
estimate
0.39
56
537
15
183
0.82
0.28
1.3
1.6
0.26
0.23
g/l
0.47
15
175
24
205
1.18
0.27
2.6
4.3
3.13
3.37
g/l
0.50
24
200
474
4814
0.94
0.27
3.9
3.9
5.71
5.71
mmol/l
0.01
450
4535
34
300
1.14
0.27
1.6
1.6
—
—
—
0
0
5
71
0.70
0.26
1.0
1.1
—
—
—
0
0
5
72
0.69
0.26
1.0
1.1
—
—
—
0
0
5
75
0.66
0.26
1.2
1.5
—
—
—
0
0
16
132
1.22
0.26
1.3
1.9
—
—
—
0
0
202
1944
1.06
0.25
9.9
7.5
1.21
1.21
mmol/l
0.77
192
1820
47
427
1.11
0.24
5.6
5.7
—
—
—
0
0
6
83
0.72
0.24
1.3
1.5
—
—
—
0
0
338
3301
1.05
0.24
4.2
4.0
19.00
481.00
e6/l
—
6
42
6
84
0.71
0.24
1.3
1.5
6.12
7.43
mmol/l
—
6
74
247
2394
1.05
0.23
2.8
2.7
—
—
estimate
—
0
0
228
2206
1.05
0.23
9.6
7.7
1.21
1.21
mmol/l
0.26
210
1948
144
1506
0.94
0.23
4.1
2.7
59.40
59.09
u/l
0.02
136
1418
372
3794
0.95
0.23
4.3
4.0
9.71
8.69
mm/h
0.96
360
3601
7
91
0.77
0.22
1.1
1.4
—
—
—
0
0
28
315
0.88
0.22
2.4
1.9
—
—
—
0
0
5
41
1.22
0.22
1.2
1.2
5.20
8.20
mm/h
—
5
41
5
42
1.19
0.21
4.2
2.4
105.80
105.93
mmol/l
—
5
42
5
42
1.19
0.21
4.2
2.4
1.14
1.19
mmol/l
—
5
42
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
15
126
1.19
0.21
1.0
1.1
2.51
1.95
eliau/ml
—
9
63
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
9
113
0.79
0.20
1.2
1.2
—
—
—
0
0
33
298
1.11
0.20
1.6
1.6
—
—
—
0
0
22
193
1.14
0.20
1.7
1.5
129.69
214.48
u/ml
1.57
13
109
44
404
1.10
0.20
1.0
1.0
—
—
—
0
0
6
50
1.20
0.19
1.0
1.3
—
—
—
0
0
48
519
0.92
0.19
1.2
1.4
30.69
20.81
iu/l
1.22
43
431
26
291
0.89
0.19
2.7
4.7
109.08
22.14
ug/l
0.37
17
229
39
426
0.91
0.19
1.5
1.4
—
—
—
0
0
6
51
1.18
0.19
1.0
1.3
—
—
—
0
0
171
1651
1.05
0.19
3.1
2.6
0.02
0.02
estimate
0.08
51
461
6
52
1.16
0.19
1.0
1.1
—
—
—
0
0
42
386
1.09
0.18
2.3
2.6
—
—
—
0
0
7
58
1.21
0.18
1.3
1.5
26.93
34.57
nmol/l
—
7
47
534
5384
0.94
0.18
12.8
12.2
23.16
20.82
mg/l
0.75
439
4271
24
214
1.13
0.17
2.2
1.5
—
—
—
0
0
7
61
1.15
0.17
1.0
1.3
20.11
10.54
u/l
—
7
55
7
62
1.13
0.17
1.1
1.4
—
—
—
0
0
7
63
1.11
0.17
1.0
1.5
—
—
—
0
0
5
67
0.74
0.17
1.2
1.2
—
—
—
0
0
17
194
0.87
0.17
1.5
2.2
6.84
4.19
iu/l
—
9
82
5
69
0.72
0.17
2.6
2.3
18.12
17.43
%
—
5
69
26
287
0.90
0.16
6.8
2.0
81.32
37.52
u/ml
0.53
26
272
52
487
1.07
0.16
1.3
1.3
225.31
291.57
u/ml
0.23
47
453
34
313
1.09
0.15
3.5
5.9
1.22
1.13
mmol/l
0.07
23
227
7
86
0.81
0.14
1.0
1.2
—
—
—
0
0
84
877
0.95
0.14
1.9
2.2
—
—
—
0
0
458
4534
1.04
0.13
3.8
3.7
—
—
—
0
0
129
1331
0.96
0.13
2.5
2.1
163.07
229.78
u/l
0.61
123
1278
110
1138
0.96
0.13
1.8
1.5
19.20
20.65
nmol/l
0.57
100
1008
35
326
1.08
0.12
1.1
1.1
1.53
1.52
g/l
0.01
35
326
25
229
1.10
0.12
1.4
1.3
—
—
—
0
0
427
4312
0.97
0.12
4.4
4.3
14.44
14.43
pmol/l
0.00
408
4048
524
5204
1.04
0.12
14.1
12.8
3.94
3.93
mmol/l
0.62
509
5082
22
201
1.10
0.11
1.6
1.5
—
41.02
—
0
5
15
167
0.90
0.11
1.1
1.4
—
—
—
0
0
13
146
0.89
0.10
1.6
1.4
82.92
80.33
pmol/l
0.03
13
140
37
392
0.94
0.10
1.3
1.4
—
—
—
0
0
5
45
1.11
0.10
1.0
1.6
—
—
—
0
0
117
1201
0.97
0.10
4.0
4.3
5.95
8.89
mg/mmol
0.79
79
784
86
888
0.96
0.09
1.9
1.8
3.69
3.53
ratio
0.42
59
681
35
330
1.06
0.09
1.1
1.1
0.96
0.90
g/l
0.62
35
330
130
1270
1.03
0.09
4.2
3.3
1.02
1.02
kg/l
0.85
75
827
192
1952
0.98
0.08
3.7
3.4
79.93
31.40
u/l
0.47
182
1872
5
61
0.82
0.08
1.2
1.2
—
—
—
0
0
53
551
0.96
0.08
1.1
1.3
116.86
158.46
u/ml
0.31
23
230
152
1549
0.98
0.08
3.5
3.6
8.27
8.49
mmol/l
0.17
131
1375
75
727
1.04
0.08
3.3
3.4
18.30
21.14
%
0.73
25
236
17
156
1.09
0.08
1.2
1.3
—
—
—
0
0
24
256
0.93
0.08
1.7
1.7
—
—
—
0
0
69
668
1.04
0.08
1.8
1.8
—
—
—
0
0
168
1652
1.02
0.07
1.3
1.4
1.03
2.11
u/ml
1.35
46
434
71
689
1.03
0.07
1.6
1.7
3.68
3.48
mmol/l
0.58
41
485
7
81
0.86
0.07
1.0
1.7
—
—
—
0
0
8
93
0.86
0.06
1.0
1.3
—
—
—
0
0
14
128
1.10
0.06
10.0
2.1
0.62
0.89
nmol/l
1.23
14
111
121
1233
0.98
0.06
1.9
2.1
0.77
1.04
mg/l
1.17
101
925
89
911
0.97
0.06
2.3
1.8
1.45
1.41
%
0.23
81
838
315
3124
1.02
0.06
9.0
9.7
4.10
3.94
e9/l
0.61
276
2705
562
5636
0.97
0.05
10.5
10.1
27.92
27.82
u/l
0.04
549
5527
25
263
0.95
0.05
1.8
1.7
—
—
—
0
0
19
202
0.94
0.05
1.5
2.0
257.95
217.48
pmol/l
1.03
19
194
297
2949
1.01
0.04
3.4
3.2
87.08
90.12
ug/l
0.15
285
2828
248
2499
0.99
0.04
5.4
6.3
11.45
11.13
umol/l
0.10
233
2391
24
251
0.95
0.04
1.3
2.0
4.10
4.60
iu/ml
—
5
54
496
4976
0.98
0.04
5.1
5.2
1.85
1.77
mu/l
0.96
481
4743
76
772
0.98
0.03
2.2
2.4
2.44
2.42
mmol/l
0.76
68
688
22
211
1.04
0.03
1.8
1.5
0.00
0.04
iu/ml
—
6
30
157
1556
1.01
0.03
2.5
3.0
2.37
2.36
mmol/l
0.83
141
1455
18
172
1.05
0.02
1.9
1.6
153.25
133.89
au/ml
—
8
59
12
113
1.06
0.01
1.1
1.1
59.60
90.65
iu/ml
—
5
28
48
472
1.02
0.01
2.2
2.3
5347.42
6073.71
u/l
0.07
21
199
565
5655
0.99
0.00
14.5
13.8
74.05
71.00
umol/l
0.80
559
5590
489
4895
0.99
0.00
11.4
10.5
92.51
93.96
ml/min/173m2
0.80
434
4394
11
111
0.99
0.00
1.3
1.3
2.40
4.08
u/ml
—
5
53
23
226
1.02
0.00
1.5
1.5
46.61
55.48
ug/l
0.50
23
226
11
109
1.01
0.00
1.0
1.3
—
—
—
0
0
601
6014
0.98
0.00
19.3
18.4
4.61
4.60
e12/l
0.05
589
5911
24
235
1.02
0.00
1.6
1.4
—
—
—
0
0
14
137
1.02
0.00
2.2
1.6
—
—
—
0
0
15
146
1.03
0.00
1.6
1.4
380.25
296.53
ug/g
—
8
75
88
884
0.99
0.00
4.8
3.5
996.25
712.76
ng/l
0.32
72
715
76
755
1.01
0.00
6.4
4.8
0.80
0.82
mmol/l
0.86
70
729
601
6009
1.00
0.00
19.3
18.4
266.05
259.67
e9/l
1.68
589
5915
24
238
1.01
0.00
1.3
1.6
—
—
—
0
0
62
620
1.00
0.00
2.9
3.6
4.81
7.30
umol/l
2.04
54
533
234
2337
1.00
0.00
3.0
2.8
70.82
72.77
nmol/l
0.57
223
2196
57
569
1.00
0.00
2.8
2.4
0.68
0.64
ug/l
0.13
30
263
37
366
1.01
0.00
1.3
1.5
—
—
—
0
0
7
76
0.92
0.00
1.0
1.2
—
240.00
—
0
7
6
60
1.00
-0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.6
—
27.20
—
0
5
8
81
0.99
-0.00
4.8
3.9
6.78
7.21
pmol/l
—
8
81
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
9.82
—
0
5
5
51
0.98
-0.00
1.2
1.1
—
47.50
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
60
1.00
-0.00
1.2
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.1
302.00
211.84
mg/l
—
5
45
5
56
0.89
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.2
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.1
85.20
35.22
mg/l
—
5
43
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
5.93
—
0
7
0
7
0.00
-0.00
0.0
3.6
—
4.14
—
0
7
6
62
0.97
-0.00
1.2
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
59
1.02
-0.00
1.2
1.4
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.4
—
—
—
0
0
5
55
0.91
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
66
0.91
-0.00
1.0
1.5
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_LIP_CLEFT_PALATE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_LIP_CLEFT_PALATE | 1.527 [1.11, 2.1] | 0.009 |
| Birth year | 0.998 [0.99, 1.01] | 0.627 |
During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 1650 females with Q17_CLEFT_LIP_CLEFT_PALATE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_LIP_CLEFT_PALATE | 1.453 [1.11, 1.9] | 0.007 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 61 out of 1668 males with Q17_CLEFT_LIP_CLEFT_PALATE died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_LIP_CLEFT_PALATE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | 0.288% |
| 5 | 0.868% | 1.897% |
| 10 | 2.146% | 4.739% |
| 15 | 4.504% | 8.678% |
| 20 | 8.001% | 14.407% |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_LIP_CLEFT_PALATE – Cleft lip, lip and palate or palate
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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