≡ Risteys
R14

Documentation Changelog GitHub Contact & Feedback

Increased muscle tone

EFO MESH Endpoint Browser PheWeb

INCREASEDMUSCLETONE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — R29.0, R29.3
  • Hospital discharge: ICD-9 — 7817
  • Hospital discharge: ICD-8 — 78850
  • Cause of death: ICD-10 — R29.0, R29.3
  • Cause of death: ICD-9 — 7817
  • Cause of death: ICD-8 — 78850

2 out of 7 registries used, show all original rules.

103

4. Check minimum number of events

None

103

5. Include endpoints

275

6. Filter based on genotype QC (FinnGen only)

268

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2783 1485 1289
Only index persons 2421 1322 1099
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.05 0.05 0.04
Median age at first event (years)
Whole population 25.36 29.73 20.19
Only index persons 27.32 31.23 22.61

-FinnGen-

Key figures

All Female Male
Number of individuals 268 176 92
Unadjusted period prevalence (%) 0.06 0.06 0.04
Median age at first event (years) 51.94 48.24 59.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
275
Matched controls
2750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M62.4
ICD-10 Finland
Contracture of muscle
2229.9
203.4
172
*
R29.3
ICD-10 Finland
Abnormal posture
+∞
66.4
61
*
R29.0
ICD-10 Finland
Tetany
+∞
36.3
34
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.8
12.3
41
121
M79.6
ICD-10 Finland
Pain in limb
2.2
9.7
145
917
R4120
NOMESCO Finland
Occupational therapy
3.7
9.7
33
99
N03AX16
ATC
[U] pregabalin
2.5
9.5
76
368
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
4.3
9.0
24
60
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.7
8.8
29
85
78850
ICD-8 Finland
Other general symptoms, Tetany
+∞
8.4
8
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
8.4
122
752
WX702
NOMESCO Finland
Supraglottic ventilation device
3.7
8.0
26
75
Z3226
NOMESCO Finland
Physiotherapist
2.4
7.6
61
293
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.8
7.5
23
64
A02BC02
ATC
pantoprazole; systemic
2.1
7.4
189
1406
M20.1
ICD-10 Finland
Hallux valgus (acquired)
3.0
7.1
32
114
TLC00
NOMESCO Finland
Insertion of intrauterine device
3.5
7.0
25
77
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
7.0
93
546
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
7.0
52
241
M25.5
ICD-10 Finland
Pain in joint
2.0
6.9
105
647
Z2221
NOMESCO Finland
Medical doctor
2.1
6.7
83
473
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.7
6.5
37
150
R4110
NOMESCO Finland
Physiotherapy
2.0
6.4
83
480
U07
ICPC
Urine symptom/complaint other
2.8
6.3
34
134
H11.3
ICD-10 Finland
Conjunctival haemorrhage
3.9
6.3
19
52
R2110
NOMESCO Finland
Giving the first information
3.5
6.3
22
67
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
6.3
48
225
M03BC51
ATC
orphenadrine, combinations; systemic
2.0
6.1
83
489
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
2.8
6.0
31
119
M76.6
ICD-10 Finland
Achilles tendinitis
3.3
6.0
23
74

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Contracture of muscle
M62.4 (45577312)
SMOKING - SMOKE2: no - SMOKE3: never - SMOKE5: Unspecified
SMOKING-2-3-0 (2002330113)
Abnormal posture
R29.3 (45582699)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Achilles tendinitis
M76.6 (45596682)
Physiotherapy
R4110 (2001310233)
tizanidine; oral
M03BX02 (21604116)
General Practice
1 (38004446)
Neurology
13 (38004458)
Orthopedic Surgery
20 (38004465)
Plantar fascial fibromatosis
M72.2 (45553265)
Tetany
R29.0 (45563297)
Hallux valgus (acquired)
M20.1 (45606152)
Pediatric Surgery
OMOP4822020 (45756819)
Inpatient Hospital
21 (8717)
Emergency Room Visit
ER (9203)
Outpatient Visit
OP (9202)
Supplier / Service Provider
OMOP5117446 (33004)
Case Management Agency
251B00000X (38004193)
Pharmacy visit
OMOP4822462 (581458)
Laboratory Visit
OMOP4822461 (32036)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
76
394
2.28
7.98
2.6
3.3
3.55
2.50
e6/l
0.34
44
184
41
167
2.71
7.17
2.3
2.5
4.40
19.85
au/ml
—
6
14
38
153
2.72
6.79
1.2
1.3
—
25.74
—
0
13
133
904
1.91
6.45
4.1
4.2
20.38
74.23
e6/l
2.30
97
612
75
429
2.03
5.95
3.8
3.7
148.59
312.84
ng/l
0.57
54
302
111
737
1.85
5.59
3.1
3.1
—
0.25
—
0
8
48
237
2.24
5.53
1.3
1.2
—
—
—
0
0
158
1196
1.75
4.92
6.2
6.8
29.17
29.02
%
0.06
150
1142
137
998
1.74
4.87
2.5
2.0
104.20
97.78
pmol/l
0.78
76
513
154
1174
1.71
4.53
6.2
6.7
56.43
56.39
%
0.02
148
1124
111
778
1.72
4.42
3.5
3.4
22.67
51.51
e6/l
1.17
89
583
152
1163
1.69
4.34
6.4
6.8
0.60
0.69
%
1.52
144
1090
117
837
1.69
4.29
5.1
6.6
—
—
—
0
0
98
675
1.70
4.10
3.3
3.3
0.18
0.42
e6/l
1.23
76
479
152
1174
1.66
4.10
6.4
6.9
8.88
8.59
%
0.69
144
1106
151
1169
1.65
4.00
6.3
6.7
2.76
2.83
%
0.15
144
1096
58
347
1.85
3.91
1.4
1.4
220.00
545.13
titre
3.44
12
78
133
1005
1.63
3.83
5.6
5.4
36.72
36.27
g/l
0.42
127
956
105
751
1.64
3.75
3.3
2.9
—
—
—
0
0
41
223
1.99
3.66
1.7
2.7
31.63
30.06
u/l
0.23
32
183
160
1274
1.61
3.65
5.8
6.7
0.04
0.04
e9/l
0.12
141
1105
162
1297
1.61
3.59
5.9
6.6
1.93
2.00
e9/l
0.27
150
1159
16
57
2.92
3.59
1.5
1.9
—
—
—
0
0
164
1317
1.61
3.58
6.0
7.1
0.20
0.19
e9/l
0.48
149
1160
159
1269
1.60
3.55
5.8
6.7
0.60
0.57
e9/l
0.84
141
1105
85
585
1.66
3.49
2.4
3.2
328.85
334.79
umol/l
0.20
73
521
93
659
1.62
3.38
2.6
2.1
2.39
2.76
mg/l
1.01
80
569
217
1883
1.72
3.35
5.4
4.4
14.28
14.69
pmol/l
1.81
207
1729
173
1423
1.58
3.29
8.1
10.2
4.20
4.00
e9/l
0.66
152
1240
67
440
1.69
3.26
2.7
2.9
512.73
515.33
mosm/kgh2o
0.03
61
387
97
702
1.59
3.21
5.5
4.2
7.39
7.40
ph
0.77
70
492
134
1045
1.55
3.19
8.5
8.0
1.22
1.22
mmol/l
0.66
128
980
158
1281
1.55
3.14
4.8
7.0
9.85
11.35
umol/l
1.88
151
1222
79
548
1.62
3.10
1.8
2.0
1.41
1.51
mg/l
0.08
69
433
144
1147
1.54
3.08
9.5
8.1
1.22
1.21
mmol/l
0.77
130
1013
9
21
4.39
3.02
1.2
2.3
—
—
—
0
0
129
1008
1.53
2.99
24.3
11.9
1.19
1.19
inr
0.02
106
833
21
96
2.29
2.92
2.6
2.4
—
—
—
0
0
92
671
1.56
2.90
2.0
1.7
20.67
20.58
nmol/l
0.02
80
565
74
513
1.61
2.89
2.8
2.7
3.55
7.29
e6/l
1.53
67
471
92
673
1.55
2.85
1.5
1.3
0.85
1.34
u/ml
0.76
11
177
100
749
1.53
2.77
2.4
2.6
55.31
68.84
u/l
0.92
91
698
65
441
1.62
2.76
1.3
1.3
15.31
10.22
u/ml
0.18
18
184
139
1116
1.50
2.76
2.9
2.6
76.46
75.73
nmol/l
0.12
128
1010
84
608
1.55
2.71
1.5
1.4
2.05
2.30
g/l
0.75
45
366
108
826
1.51
2.70
3.6
3.3
2.35
2.36
mmol/l
0.50
96
755
124
982
1.48
2.59
1.9
1.9
1.35
1.33
mmol/l
0.13
111
835
41
253
1.73
2.48
8.0
11.6
0.96
0.85
mmol/l
0.06
32
213
204
1795
1.53
2.44
7.6
8.4
80.19
80.95
u/l
0.06
197
1706
159
1332
1.46
2.43
4.0
3.8
62.04
5.86
estimate
0.42
23
277
153
1278
1.44
2.34
3.8
3.0
92.68
96.87
ug/l
0.15
145
1190
132
1073
1.44
2.34
3.1
3.4
6.37
6.25
ph
0.52
57
583
16
72
2.30
2.32
1.4
1.3
—
—
—
0
0
120
961
1.44
2.29
2.5
2.0
—
—
—
0
0
30
173
1.82
2.28
3.6
3.7
64.74
66.19
g/l
0.47
25
162
41
260
1.68
2.26
8.2
11.3
7.42
7.41
ph
0.38
17
152
33
197
1.77
2.25
4.0
2.2
6.57
6.12
ph
2.26
21
129
159
1345
1.43
2.23
4.2
3.8
0.00
0.01
estimate
0.50
18
256
225
2043
1.56
2.13
23.0
18.5
13.45
13.49
%
0.24
220
2029
10
37
2.77
2.09
1.2
1.2
—
—
—
0
0
35
218
1.69
2.07
1.5
2.6
9.81
10.42
g/l
0.53
30
204
32
195
1.73
2.04
1.3
1.3
177.30
131.25
u/ml
—
10
79
82
623
1.45
2.04
4.7
4.1
—
—
—
0
0
34
211
1.70
2.03
7.4
11.9
—
—
—
0
0
19
98
2.01
2.00
1.7
1.8
—
—
—
0
0
155
1323
1.39
1.96
3.8
3.7
0.00
0.00
estimate
-0.00
22
278
6
16
3.81
1.94
1.0
1.1
—
—
—
0
0
51
357
1.53
1.88
1.8
1.6
885.76
1223.77
nmol/l
2.78
36
272
40
265
1.60
1.87
1.3
1.3
—
—
—
0
0
162
1400
1.38
1.87
5.8
5.8
6.49
6.50
mmol/l
0.02
154
1312
94
745
1.40
1.83
6.7
7.2
—
—
—
0
0
20
109
1.90
1.82
2.1
1.8
—
—
—
0
0
184
1628
1.39
1.81
3.5
3.5
38.89
42.58
u/l
0.37
177
1552
25
147
1.77
1.81
4.7
4.0
4.43
4.63
pmol/l
0.67
25
130
64
477
1.45
1.74
1.5
1.3
13.16
29.28
iu/ml
2.58
23
155
25
149
1.75
1.74
1.4
1.3
—
—
—
0
0
14
68
2.12
1.73
1.4
2.3
—
—
—
0
0
11
48
2.35
1.73
1.2
1.1
—
—
—
0
0
11
48
2.35
1.73
1.2
1.1
—
—
—
0
0
15
76
2.03
1.68
1.1
1.2
—
—
—
0
0
23
137
1.74
1.61
1.4
3.0
—
—
—
0
0
8
32
2.54
1.61
2.0
2.6
—
—
—
0
0
7
26
2.74
1.59
1.4
1.3
—
—
—
0
0
238
2224
1.52
1.58
6.8
5.4
1.79
1.88
mu/l
0.75
228
2068
12
57
2.16
1.57
3.3
3.0
0.00
1.77
index
—
5
35
135
1157
1.33
1.53
2.9
2.9
—
—
estimate
—
0
0
78
617
1.37
1.50
2.3
2.1
—
—
—
0
0
11
55
2.04
1.29
4.4
3.1
28.55
32.80
umol/l
0.43
11
50
226
2117
1.38
1.23
6.5
6.1
37.86
38.82
mmol/mol
1.03
218
2003
72
580
1.33
1.22
3.6
3.7
1.02
1.02
kg/l
0.44
50
374
42
311
1.41
1.20
1.4
1.2
—
—
—
0
0
8
38
2.14
1.19
1.3
1.2
—
—
—
0
0
23
151
1.57
1.16
5.8
5.7
23.91
24.19
mmol/l
0.17
23
151
255
2448
1.57
1.14
12.6
11.9
25.08
26.16
u/l
0.53
250
2397
10
51
2.00
1.12
1.1
2.0
—
—
—
0
0
246
2348
1.45
1.10
23.0
17.6
3.95
3.96
mmol/l
0.15
241
2307
248
2371
1.47
1.09
21.0
14.9
24.62
22.79
mg/l
0.35
203
1899
56
444
1.33
1.06
1.9
1.8
147917058.46
446.63
pmol/l
0.49
48
376
7
35
2.03
1.00
1.0
1.5
0.37
0.49
nmol/l
—
7
30
7
36
1.97
0.97
1.0
1.1
—
—
—
0
0
6
28
2.17
0.92
1.0
1.2
—
—
—
0
0
56
455
1.29
0.90
2.1
2.4
2.42
2.44
mmol/l
0.57
44
413
15
95
1.61
0.89
1.4
2.2
1.45
1.46
g/l
0.02
15
85
39
302
1.34
0.87
1.4
1.5
—
—
—
0
0
17
112
1.55
0.87
1.1
1.1
—
—
—
0
0
13
80
1.66
0.86
1.1
1.2
—
76.36
—
0
11
19
129
1.51
0.86
1.5
1.8
—
—
—
0
0
33
250
1.36
0.85
5.3
5.1
7.35
7.39
ph
2.45
22
154
6
31
1.96
0.85
1.0
1.2
—
—
—
0
0
12
73
1.67
0.83
1.9
2.0
22.68
23.95
mmol/l
0.49
12
73
92
801
1.22
0.82
3.6
3.5
7.91
7.70
mmol/l
0.17
78
679
69
583
1.25
0.81
4.5
4.5
92.72
92.48
%
0.03
69
577
16
106
1.54
0.81
1.3
1.2
—
—
—
0
0
27
200
1.39
0.80
11.9
9.0
11.49
9.11
mmol/l
0.46
27
193
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
33
254
1.34
0.78
1.2
1.4
—
—
—
0
0
7
38
1.86
0.74
2.4
2.1
—
—
—
0
0
224
2141
1.25
0.71
4.2
4.1
1.27
1.25
mmol/l
0.10
215
1986
5
26
1.94
0.71
1.6
2.7
—
—
—
0
0
42
340
1.28
0.71
2.0
1.6
—
—
—
0
0
7
41
1.73
0.70
1.0
1.1
—
—
—
0
0
37
295
1.29
0.70
3.0
1.6
—
—
—
0
0
14
202
0.68
0.68
4.6
3.5
—
—
—
0
0
29
224
1.33
0.68
3.3
2.0
0.00
0.00
estimate
—
5
52
12
78
1.56
0.66
12.6
9.4
—
—
—
0
0
7
44
1.61
0.65
1.1
1.7
—
—
—
0
0
61
521
1.22
0.65
1.8
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
83
930
0.85
0.60
3.1
3.1
—
—
—
0
0
19
140
1.38
0.60
1.2
1.4
0.31
0.30
mg/l
0.05
12
55
22
167
1.34
0.59
7.5
10.5
24.85
24.83
mmol/l
0.01
22
167
123
1131
1.16
0.56
8.7
11.0
0.00
0.00
e9/l
0.33
94
924
11
74
1.51
0.54
1.3
1.3
—
—
—
0
0
88
792
1.16
0.53
2.4
2.4
—
—
—
0
0
41
344
1.23
0.53
3.4
2.1
—
—
—
0
0
17
126
1.37
0.53
5.3
9.0
—
—
—
0
0
79
707
1.16
0.51
3.9
3.5
77.27
73.98
mg/l
0.03
55
455
30
244
1.26
0.51
4.9
5.1
1.37
1.64
mmol/l
0.14
23
207
38
318
1.23
0.50
7.8
7.6
104.08
104.31
mmol/l
0.12
38
318
62
547
1.17
0.48
6.4
5.3
2.17
1.93
ug/l
0.26
57
483
232
2252
1.19
0.46
5.1
4.8
1.51
1.49
mmol/l
0.34
221
2097
44
378
1.20
0.46
2.4
2.3
48.11
111.78
ug/g
3.06
38
299
233
2263
1.19
0.45
5.2
4.9
4.75
4.65
mmol/l
0.79
224
2124
11
78
1.43
0.44
1.6
1.4
325.50
327.33
ug/g
—
6
44
5
31
1.62
0.43
1.2
1.5
21.56
34.75
ng/l
—
5
31
0
15
0.00
0.41
0.0
2.3
—
0.87
—
0
15
0
15
0.00
0.41
0.0
3.1
—
666.50
—
0
6
235
2289
1.18
0.41
6.1
5.4
2.77
2.72
mmol/l
0.37
225
2136
24
198
1.23
0.38
4.7
4.6
7.29
7.35
ph
0.42
19
143
5
37
1.36
0.37
1.8
1.8
—
—
—
0
0
5
37
1.36
0.37
1.8
1.8
—
—
—
0
0
5
37
1.36
0.37
1.8
1.8
—
—
—
0
0
5
37
1.36
0.37
1.8
1.8
—
—
—
0
0
21
171
1.25
0.37
1.3
1.3
—
—
—
0
0
227
2213
1.15
0.34
5.0
4.8
5.79
5.81
mmol/l
0.13
215
2045
66
719
0.89
0.32
4.1
3.7
0.00
0.01
estimate
0.74
21
259
92
859
1.11
0.31
4.1
3.9
102.86
103.04
ng/l
0.00
49
586
35
307
1.16
0.30
1.2
1.3
—
—
—
0
0
25
215
1.18
0.28
1.7
1.5
—
—
—
0
0
77
718
1.10
0.26
4.3
4.2
16.76
12.63
mg/mmol
0.21
49
450
36
321
1.14
0.26
3.1
3.0
0.77
0.76
ug/l
0.02
24
207
248
2443
1.15
0.25
16.1
12.9
—
—
—
0
0
13
106
1.24
0.23
1.6
1.4
155.89
281.05
miu/ml
—
8
55
16
134
1.21
0.23
1.3
1.1
—
—
—
0
0
5
39
1.29
0.23
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
3.97
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
27.40
—
0
10
0
10
0.00
0.21
0.0
1.5
—
58.60
—
0
10
0
10
0.00
0.21
0.0
1.1
—
171.07
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
11
89
1.25
0.21
1.3
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
3.2
—
501.67
—
0
6
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
13
108
1.21
0.20
1.3
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
16.83
—
0
14
0
14
0.00
0.20
0.0
1.3
—
186.71
—
0
14
18
206
0.86
0.19
1.5
1.7
685.28
935.37
mu/l
0.86
12
185
24
214
1.13
0.18
1.7
1.8
3.45
3.47
mmol/l
0.03
18
158
11
92
1.20
0.16
1.4
1.6
—
—
—
0
0
38
352
1.09
0.16
1.9
1.6
—
—
—
0
0
14
121
1.17
0.15
5.7
6.3
—
—
—
0
0
7
89
0.78
0.14
3.0
7.5
1.90
1.30
mg/l
—
7
81
16
141
1.14
0.14
5.3
2.5
33.25
45.54
u/ml
0.27
16
135
103
996
1.05
0.13
3.7
3.5
0.00
0.02
estimate
0.78
16
231
15
132
1.14
0.13
2.1
1.5
—
—
—
0
0
77
741
1.05
0.12
3.5
3.2
0.00
0.00
estimate
-0.00
17
227
5
46
1.09
0.09
2.4
1.8
6.28
6.87
pmol/l
—
5
46
12
108
1.12
0.07
1.1
3.1
20.83
21.82
s
0.48
12
100
9
86
1.05
0.07
2.0
1.9
0.65
4.22
ug/l
—
9
78
22
207
1.07
0.06
1.6
3.6
58.68
72.19
e9/l
1.63
12
151
79
773
1.03
0.05
1.6
1.6
—
—
—
0
0
39
376
1.04
0.05
1.9
1.8
—
—
—
0
0
22
229
0.96
0.03
1.9
4.5
2.48
35.46
ug/l
0.58
15
191
61
600
1.02
0.02
2.9
4.8
—
—
—
0
0
14
147
0.95
0.01
2.1
1.5
—
—
—
0
0
11
104
1.06
0.01
3.8
4.9
36.87
36.94
°c
0.24
11
104
13
124
1.05
0.00
2.8
2.0
0.00
0.00
estimate
—
6
44
15
144
1.04
0.00
2.1
1.5
—
—
—
0
0
20
199
1.01
0.00
1.3
1.5
—
—
—
0
0
15
145
1.04
0.00
2.1
1.5
—
—
—
0
0
14
144
0.97
0.00
2.1
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
26.33
—
0
6
0
6
0.00
0.00
0.0
1.2
—
1.21
—
0
6
0
6
0.00
0.00
0.0
5.0
—
1.98
—
0
6
0
6
0.00
0.00
0.0
4.8
—
42.17
—
0
6
0
6
0.00
0.00
0.0
6.5
—
3.06
—
0
6
0
6
0.00
0.00
0.0
9.8
—
8.04
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
2.61
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
8
83
0.96
-0.00
1.1
1.1
1.51
1.58
g/l
—
8
83
8
85
0.94
-0.00
1.1
1.2
0.75
0.89
g/l
—
8
85
0
5
0.00
-0.00
0.0
1.6
—
11.32
—
0
5
7
75
0.93
-0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
28.6
—
149.40
—
0
5
7
70
1.00
-0.00
1.1
2.1
12.49
11.42
mg/l
—
7
65
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
60.60
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.6
—
16.38
—
0
5
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
154.33
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
2.5
1.8
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint INCREASEDMUSCLETONE and mortality.

Females

Parameter HR [95% CI] p-value
INCREASEDMUSCLETONE 1.498 [1.12, 2.01] 0.006
Birth year 0.997 [0.99, 1.01] 0.455

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1243 females with INCREASEDMUSCLETONE died.

Males

Parameter HR [95% CI] p-value
INCREASEDMUSCLETONE 1.505 [1.12, 2.02] 0.006
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 1128 males with INCREASEDMUSCLETONE died.

Mortality risk

Mortality risk for people of age

years, who have INCREASEDMUSCLETONE.

N-year risk Females Males
1 0.187% 0.339%
5 0.974% 1.718%
10 2.335% 4.324%
15 4.498% 8.337%
20 7.859% 13.408%

Relationships between endpoints

↥

Index endpoint: INCREASEDMUSCLETONE – Increased muscle tone

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data