No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
112 |
4. Check minimum number of eventsNone |
112 |
5. Include endpoints |
294 |
6. Filter based on genotype QC (FinnGen only) |
268 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF3
Increased muscle tone
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2783 | 1485 | 1289 |
| Only index persons | 2421 | 1322 | 1099 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 25.36 | 29.73 | 20.19 |
| Only index persons | 27.32 | 31.23 | 22.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 268 | 176 | 92 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.04 |
| Median age at first event (years) | 51.94 | 48.24 | 59.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 275
- Matched controls
- 2750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M62.4
ICD-10 Finland
Contracture of muscle
2229.9
203.4
172
*
R29.3
ICD-10 Finland
Abnormal posture
+∞
66.4
61
*
R29.0
ICD-10 Finland
Tetany
+∞
36.3
34
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.8
12.3
41
121
M79.6
ICD-10 Finland
Pain in limb
2.2
9.7
145
917
R4120
NOMESCO Finland
Occupational therapy
3.7
9.7
33
99
N03AX16
ATC
[U] pregabalin
2.5
9.5
76
368
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
4.3
9.0
24
60
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.7
8.8
29
85
78850
ICD-8 Finland
Other general symptoms, Tetany
+∞
8.4
8
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
8.4
122
752
WX702
NOMESCO Finland
Supraglottic ventilation device
3.7
8.0
26
75
Z3226
NOMESCO Finland
Physiotherapist
2.4
7.6
61
293
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.8
7.5
23
64
A02BC02
ATC
pantoprazole; systemic
2.1
7.4
189
1406
M20.1
ICD-10 Finland
Hallux valgus (acquired)
3.0
7.1
32
114
TLC00
NOMESCO Finland
Insertion of intrauterine device
3.5
7.0
25
77
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
7.0
93
546
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
7.0
52
241
M25.5
ICD-10 Finland
Pain in joint
2.0
6.9
105
647
Z2221
NOMESCO Finland
Medical doctor
2.1
6.7
83
473
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.7
6.5
37
150
R4110
NOMESCO Finland
Physiotherapy
2.0
6.4
83
480
U07
ICPC
Urine symptom/complaint other
2.8
6.3
34
134
H11.3
ICD-10 Finland
Conjunctival haemorrhage
3.9
6.3
19
52
R2110
NOMESCO Finland
Giving the first information
3.5
6.3
22
67
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
6.3
48
225
M03BC51
ATC
orphenadrine, combinations; systemic
2.0
6.1
83
489
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
2.8
6.0
31
119
M76.6
ICD-10 Finland
Achilles tendinitis
3.3
6.0
23
74
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
76
394
2.28
7.98
2.6
3.3
3.55
2.50
e6/l
0.34
44
184
41
167
2.71
7.17
2.3
2.5
4.40
19.85
au/ml
—
6
14
38
153
2.72
6.79
1.2
1.3
—
25.74
—
0
13
127
844
1.94
6.65
3.3
3.4
—
—
—
0
0
75
429
2.03
5.95
3.8
3.7
148.59
312.84
ng/l
0.57
54
302
74
426
2.01
5.75
2.9
3.2
1.03
0.86
e6/l
0.19
43
214
137
998
1.74
4.87
2.5
2.0
104.20
97.78
pmol/l
0.78
76
513
98
675
1.70
4.10
3.3
3.3
0.18
0.42
e6/l
1.23
76
479
47
259
1.98
4.05
2.2
1.9
—
—
—
0
0
48
268
1.96
3.98
2.2
1.9
—
—
—
0
0
133
1005
1.63
3.83
5.6
5.4
36.72
36.27
g/l
0.42
127
956
33
165
2.14
3.68
1.1
1.0
—
—
—
0
0
41
223
1.99
3.66
1.7
2.7
31.63
30.06
u/l
0.23
32
183
85
585
1.66
3.49
2.4
3.2
328.85
334.79
umol/l
0.20
73
521
59
370
1.76
3.39
2.2
2.0
—
—
—
0
0
93
659
1.62
3.38
2.6
2.1
2.39
2.76
mg/l
1.01
80
569
217
1883
1.72
3.35
5.4
4.4
14.28
14.69
pmol/l
1.81
207
1729
19
78
2.54
3.29
1.4
1.4
—
—
—
0
0
173
1423
1.58
3.29
8.1
10.2
4.20
4.00
e9/l
0.66
152
1240
134
1045
1.55
3.19
8.5
8.0
1.22
1.22
mmol/l
0.66
128
980
158
1281
1.55
3.14
4.8
7.0
9.85
11.35
umol/l
1.88
151
1222
79
548
1.62
3.10
1.8
2.0
1.41
1.51
mg/l
0.08
69
433
144
1147
1.54
3.08
9.5
8.1
1.22
1.21
mmol/l
0.77
130
1013
92
671
1.56
2.90
2.0
1.7
20.67
20.58
nmol/l
0.02
80
565
92
673
1.55
2.85
1.5
1.3
0.85
1.34
u/ml
0.76
11
177
192
1645
1.55
2.82
3.8
3.5
—
—
—
0
0
100
749
1.53
2.77
2.4
2.6
55.31
68.84
u/l
0.92
91
698
65
441
1.62
2.76
1.3
1.3
15.31
10.22
u/ml
0.18
18
184
139
1116
1.50
2.76
2.9
2.6
76.46
75.73
nmol/l
0.12
128
1010
203
1768
1.57
2.71
5.0
4.4
12.59
10.98
mm/h
0.74
194
1639
108
826
1.51
2.70
3.6
3.3
2.35
2.36
mmol/l
0.50
96
755
124
982
1.48
2.59
1.9
1.9
1.35
1.33
mmol/l
0.13
111
835
41
253
1.73
2.48
8.0
11.6
0.96
0.85
mmol/l
0.06
32
213
204
1795
1.53
2.44
7.6
8.4
80.19
80.95
u/l
0.06
197
1706
159
1332
1.46
2.43
4.0
3.8
62.04
5.86
estimate
0.42
23
277
59
404
1.59
2.40
2.5
2.3
—
—
—
0
0
16
71
2.33
2.39
1.4
1.2
—
—
—
0
0
153
1278
1.44
2.34
3.8
3.0
92.68
96.87
ug/l
0.15
145
1190
16
72
2.30
2.32
1.4
1.2
—
—
—
0
0
30
173
1.82
2.28
3.6
3.7
64.74
66.19
g/l
0.47
25
162
159
1345
1.43
2.23
4.2
3.8
0.00
0.01
estimate
0.50
18
256
5
9
5.63
2.22
1.2
1.2
—
—
—
0
0
8
24
3.40
2.19
1.1
1.1
—
—
—
0
0
8
24
3.40
2.19
1.1
1.1
—
—
—
0
0
225
2043
1.56
2.13
23.0
18.5
13.45
13.49
%
0.24
220
2029
54
374
1.55
2.09
2.2
2.2
—
—
—
0
0
32
195
1.73
2.04
1.3
1.3
177.30
131.25
u/ml
—
10
79
155
1323
1.39
1.96
3.8
3.7
0.00
0.00
estimate
-0.00
22
278
5
11
4.61
1.95
1.0
1.5
—
—
—
0
0
51
357
1.53
1.88
1.8
1.6
885.76
1223.77
nmol/l
2.78
36
272
162
1400
1.38
1.87
5.8
5.8
6.49
6.50
mmol/l
0.02
154
1312
15
73
2.12
1.84
1.4
1.2
—
—
—
0
0
184
1628
1.39
1.81
3.5
3.5
38.89
42.58
u/l
0.37
177
1552
25
147
1.77
1.81
4.7
4.0
4.43
4.63
pmol/l
0.67
25
130
27
164
1.72
1.76
2.1
1.5
—
—
—
0
0
64
477
1.45
1.74
1.5
1.3
13.16
29.28
iu/ml
2.58
23
155
17
89
1.97
1.74
1.6
1.3
—
—
—
0
0
22
129
1.77
1.62
1.5
1.4
—
—
—
0
0
6
20
3.04
1.59
1.3
1.2
—
—
—
0
0
238
2224
1.52
1.58
6.8
5.4
1.79
1.88
mu/l
0.75
228
2068
12
57
2.16
1.57
3.3
3.0
0.00
1.77
index
—
5
35
135
1157
1.33
1.53
2.9
2.9
—
—
estimate
—
0
0
101
832
1.34
1.50
3.1
3.7
28.12
30.94
u/l
0.84
95
787
9
40
2.29
1.41
1.2
1.3
—
—
—
0
0
9
40
2.29
1.41
1.2
1.3
—
—
—
0
0
15
255
0.56
1.35
12.7
6.4
—
—
—
0
0
22
137
1.66
1.34
1.4
1.4
—
—
—
0
0
11
55
2.04
1.29
4.4
3.1
28.55
32.80
umol/l
0.43
11
50
226
2117
1.38
1.23
6.5
6.1
37.86
38.82
mmol/mol
1.03
218
2003
72
580
1.33
1.22
3.6
3.7
1.02
1.02
kg/l
0.44
50
374
6
26
2.34
1.19
1.0
1.4
—
—
—
0
0
23
151
1.57
1.16
5.8
5.7
23.91
24.19
mmol/l
0.17
23
151
255
2448
1.57
1.14
12.6
11.9
25.08
26.16
u/l
0.53
250
2397
246
2348
1.45
1.10
23.0
17.6
3.95
3.96
mmol/l
0.15
241
2307
248
2371
1.47
1.09
21.0
14.9
24.62
22.79
mg/l
0.35
203
1899
56
444
1.33
1.06
1.9
1.8
147917058.46
446.63
pmol/l
0.49
48
376
9
48
1.90
1.01
1.4
1.5
—
—
—
0
0
7
35
2.03
1.00
1.0
1.5
0.37
0.49
nmol/l
—
7
30
9
51
1.79
0.95
1.1
1.3
—
—
—
0
0
7
37
1.91
0.94
1.1
1.4
6.56
7.31
mmol/l
—
7
30
6
27
2.25
0.94
1.0
1.3
—
—
—
0
0
22
151
1.50
0.94
4.6
5.7
0.69
1.46
mmol/l
0.54
15
109
6
28
2.17
0.92
1.2
2.1
—
—
—
0
0
56
455
1.29
0.90
2.1
2.4
2.42
2.44
mmol/l
0.57
44
413
6
29
2.09
0.90
1.0
1.2
—
—
—
0
0
6
29
2.09
0.90
1.0
1.2
—
—
—
0
0
20
136
1.51
0.89
2.3
1.8
—
—
—
0
0
15
95
1.61
0.89
1.4
2.2
1.45
1.46
g/l
0.02
15
85
77
653
1.25
0.87
3.1
3.6
1284.17
1136.08
ng/l
0.10
64
546
6
30
2.02
0.87
1.0
1.2
—
—
—
0
0
6
30
2.02
0.87
1.0
1.2
—
—
—
0
0
16
104
1.57
0.86
2.1
1.7
—
—
—
0
0
33
250
1.36
0.85
2.5
2.2
—
—
—
0
0
6
31
1.96
0.85
1.0
1.4
—
—
—
0
0
12
73
1.67
0.83
1.9
2.0
22.68
23.95
mmol/l
0.49
12
73
53
433
1.28
0.82
5.6
4.4
20.76
22.98
%
0.57
25
215
8
47
1.72
0.81
3.3
8.5
—
233.22
—
0
9
15
98
1.56
0.80
1.3
1.5
—
—
—
0
0
27
200
1.39
0.80
11.9
9.0
11.49
9.11
mmol/l
0.46
27
193
6
33
1.84
0.79
1.0
1.2
—
—
—
0
0
6
33
1.84
0.79
1.2
1.9
—
—
—
0
0
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
15
100
1.53
0.74
1.3
1.5
1.15
1.19
ratio
—
8
57
15
100
1.53
0.74
1.3
1.5
1.13
1.18
ratio
—
8
57
15
100
1.53
0.74
1.3
1.5
1.10
0.93
ratio
—
8
57
28
213
1.35
0.72
2.0
2.1
—
—
—
0
0
224
2141
1.25
0.71
4.2
4.1
1.27
1.25
mmol/l
0.10
215
1986
12
77
1.58
0.69
1.5
1.4
—
—
—
0
0
5
93
0.53
0.68
1.4
1.4
—
—
—
0
0
229
2199
1.25
0.66
16.7
14.1
86.79
84.89
ml/min/173m2
0.61
211
2027
35
279
1.29
0.66
2.1
2.0
3.36
3.38
ratio
0.03
29
224
69
600
1.20
0.62
2.7
2.5
—
—
—
0
0
55
468
1.22
0.61
1.7
1.5
—
—
—
0
0
19
140
1.38
0.60
1.2
1.4
0.31
0.30
mg/l
0.05
12
55
22
167
1.34
0.59
7.5
10.5
24.85
24.83
mmol/l
0.01
22
167
23
176
1.33
0.58
1.8
1.4
—
—
—
0
0
18
133
1.38
0.56
1.4
1.5
—
—
—
0
0
6
38
1.59
0.54
1.0
1.3
—
—
—
0
0
30
244
1.26
0.51
4.9
5.1
1.37
1.64
mmol/l
0.14
23
207
38
318
1.23
0.50
7.8
7.6
104.08
104.31
mmol/l
0.12
38
318
62
547
1.17
0.48
6.4
5.3
2.17
1.93
ug/l
0.26
57
483
10
68
1.49
0.47
4.2
2.8
—
—
—
0
0
232
2252
1.19
0.46
5.1
4.8
1.51
1.49
mmol/l
0.34
221
2097
233
2263
1.19
0.45
5.2
4.9
4.75
4.65
mmol/l
0.79
224
2124
11
78
1.43
0.44
1.6
1.4
325.50
327.33
ug/g
—
6
44
8
56
1.44
0.43
2.6
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
3.7
—
1.33
—
0
15
235
2289
1.18
0.41
6.1
5.4
2.77
2.72
mmol/l
0.37
225
2136
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
23
187
1.25
0.40
3.4
2.9
54.27
68.27
ml/min/173m2
1.22
15
78
9
67
1.35
0.38
1.2
1.4
—
55.23
—
0
11
6
44
1.37
0.34
1.8
6.4
—
4983.20
—
0
5
227
2213
1.15
0.34
5.0
4.8
5.79
5.81
mmol/l
0.13
215
2045
6
89
0.67
0.33
1.5
1.7
—
—
—
0
0
66
719
0.89
0.32
4.1
3.7
0.00
0.01
estimate
0.74
21
259
7
98
0.71
0.31
2.3
1.7
—
—
—
0
0
92
859
1.11
0.31
4.1
3.9
102.86
103.04
ng/l
0.00
49
586
7
56
1.26
0.29
1.7
1.5
—
—
—
0
0
8
63
1.28
0.28
1.0
1.5
—
—
—
0
0
77
718
1.10
0.26
4.3
4.2
16.76
12.63
mg/mmol
0.21
49
450
36
321
1.14
0.26
3.1
3.0
0.77
0.76
ug/l
0.02
24
207
12
96
1.26
0.25
1.2
1.9
—
—
—
0
0
13
106
1.24
0.23
1.6
1.4
155.89
281.05
miu/ml
—
8
55
5
38
1.32
0.23
1.4
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
9.29
—
0
11
0
11
0.00
0.21
0.0
1.0
—
6.00
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
186.71
—
0
14
0
14
0.00
0.20
0.0
3.5
—
—
—
0
0
0
14
0.00
0.20
0.0
3.5
—
—
—
0
0
6
50
1.20
0.20
4.2
1.6
—
—
—
0
0
18
206
0.86
0.19
1.5
1.7
685.28
935.37
mu/l
0.86
12
185
24
214
1.13
0.18
1.7
1.8
3.45
3.47
mmol/l
0.03
18
158
8
69
1.16
0.16
1.3
1.4
—
—
—
0
0
16
141
1.14
0.14
5.3
2.5
33.25
45.54
u/ml
0.27
16
135
10
84
1.20
0.14
1.5
1.4
—
2.75
—
0
15
103
996
1.05
0.13
3.7
3.5
0.00
0.02
estimate
0.78
16
231
10
85
1.18
0.12
1.5
1.4
—
6.41
—
0
22
77
741
1.05
0.12
3.5
3.2
0.00
0.00
estimate
-0.00
17
227
5
46
1.09
0.09
2.4
1.8
6.28
6.87
pmol/l
—
5
46
61
588
1.05
0.09
2.4
1.7
—
—
—
0
0
10
88
1.14
0.08
1.5
1.4
—
2.58
—
0
6
7
64
1.10
0.08
1.6
1.7
—
—
—
0
0
7
81
0.86
0.07
1.6
1.9
—
—
—
0
0
9
86
1.05
0.07
2.0
1.9
0.65
4.22
ug/l
—
9
78
22
231
0.95
0.04
3.2
3.2
—
—
—
0
0
22
229
0.96
0.03
1.9
4.5
2.48
35.46
ug/l
0.58
15
191
29
289
1.00
0.00
4.1
4.6
30.57
31.68
%
0.22
21
195
5
49
1.02
0.00
2.4
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
54.43
—
0
7
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
71
0.99
-0.00
1.3
1.4
—
1.00
—
0
8
9
95
0.95
-0.00
2.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
8.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.2
—
185.56
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.35
—
0
5
5
50
1.00
-0.00
1.4
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
65
0.92
-0.00
2.0
1.8
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.2
0.75
0.89
g/l
—
8
85
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
83
0.96
-0.00
1.1
1.1
1.51
1.58
g/l
—
8
83
8
83
0.96
-0.00
1.6
2.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint INCREASEDMUSCLETONE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| INCREASEDMUSCLETONE | 1.498 [1.12, 2.01] | 0.006 |
| Birth year | 0.997 [0.99, 1.01] | 0.455 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1243 females with INCREASEDMUSCLETONE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| INCREASEDMUSCLETONE | 1.505 [1.12, 2.02] | 0.006 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 1128 males with INCREASEDMUSCLETONE died.
Mortality risk
Mortality risk for people of age
years, who have INCREASEDMUSCLETONE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.187% | 0.339% |
| 5 | 0.974% | 1.718% |
| 10 | 2.335% | 4.324% |
| 15 | 4.498% | 8.337% |
| 20 | 7.859% | 13.408% |
Relationships between endpoints
↥Index endpoint: INCREASEDMUSCLETONE – Increased muscle tone
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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