No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
530 |
4. Check minimum number of eventsNone |
530 |
5. Include endpointsNone |
530 |
6. Filter based on genotype QC (FinnGen only) |
484 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D68
- Name in latin
- Morbus von Willebrand
Similar endpoints
↥List of similar endpoints to
Von Willebrand disease
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3361 | 2297 | 1052 |
| Only index persons | 3158 | 2208 | 950 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.07 | 0.03 |
| Only index persons | 0.07 | 0.08 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 28.87 | 33.42 | 18.84 |
| Only index persons | 28.84 | 33.23 | 18.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 484 | 408 | 76 |
| Unadjusted period prevalence (%) | 0.13 | 0.14 | 0.03 |
| Median age at first event (years) | 37.86 | 37.84 | 37.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 502
- Matched controls
- 5020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
307.7
488
*
B02AA02
ATC
tranexamic acid; systemic
22.3
270.4
380
616
126
Kela drug reimbursment
Chronic coagulation defects
+∞
147.3
134
*
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
46.4
90.6
54
13
D68.9
ICD-10 Finland
Coagulation defect, unspecified
+∞
69.4
65
*
D68.8
ICD-10 Finland
Other specified coagulation defects
166.7
57.2
59
*
2864A
ICD-9 Finland
Coagulation defects, von Willebrand's disease
+∞
40.1
38
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
10.9
39.5
44
44
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.6
39.3
68
116
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
136.7
36.2
38
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
5.6
31.5
65
131
28630
ICD-8 Finland
Coagulation defects, Vascular haemophilia
+∞
30.5
29
*
N02AX02
ATC
tramadol; systemic, rectal
2.7
27.0
260
1416
EBA10
NOMESCO Finland
Operative extraction of tooth
3.1
24.9
131
514
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
3.1
22.9
112
420
R04.0
ICD-10 Finland
Epistaxis
4.5
22.7
60
148
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
20.7
267
1606
M01AE01
ATC
ibuprofen; systemic, rectal
0.4
19.3
351
4300
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
18.4
246
1480
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
6.1
18.1
32
55
2BD06, ,
NOMESCO Finland
+∞
17.8
17
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.2
17.3
232
1389
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
+∞
16.8
16
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.8
16.4
53
151
ZX120
NOMESCO Finland
Intravenous
3.3
16.4
69
234
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
16.4
166
880
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.7
16.3
101
426
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.1
14.7
199
1177
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
16.0
14.5
23
15
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
14.1
198
1185
R42
ICD-10 Finland
Dizziness and giddiness
2.3
13.9
133
682
ZXE00
NOMESCO Finland
One hour or less
2.1
13.9
230
1461
D66
ICD-10 Finland
Hereditary factor VIII deficiency
+∞
13.6
13
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.3
13.4
53
173
UJF32
NOMESCO Finland
Coloscopy
2.2
13.1
135
711
N02AJ06
ATC
codeine and paracetamol; systemic
2.0
12.8
246
1633
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
12.5
12
*
194
Kela drug reimbursment
Blood coagulation factor VIII and von Willebrand factor for the treatment of von Willebrand disease
+∞
12.5
12
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
12.5
203
1268
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.8
12.3
67
262
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
11.8
174
1046
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
11.5
242
1637
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
11.5
132
723
R01AD12
ATC
fluticasone furoate; nasal
1.9
11.4
212
1376
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
25.7
11.2
15
6
R51.80
ICD-10 Finland
Headache
2.1
11.2
123
661
K01.0
ICD-10 Finland
Embedded teeth
5.2
11.1
23
46
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.4
10.8
79
358
AA1AD
NOMESCO Finland
CT of head and brain
2.1
10.7
132
740
H02AB06
ATC
prednisolone; systemic
1.9
10.7
248
1720
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
10.5
77
348
B02BD02
ATC
coagulation factor VIII; parenteral
+∞
10.4
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
10.2
115
623
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
2.6
10.1
60
245
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.0
9.9
150
900
G43.9
ICD-10 Finland
Migraine, unspecified
2.5
9.9
65
279
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.5
9.9
24
55
SAA03
NOMESCO Finland
Extended examination of mouth
1.8
9.9
245
1721
K08.3
ICD-10 Finland
Retained dental root
3.0
9.9
44
154
N02BE01
ATC
paracetamol; systemic, rectal
2.7
9.7
458
3982
J01DB01
ATC
cefalexin; oral
2.3
9.5
436
3718
B02BD06
ATC
von Willebrand factor and coagulation factor VIII in combination; parenteral, topical, urethral
+∞
9.4
9
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
9.2
92
473
3AC01, ,
NOMESCO Finland
14.0
9.2
15
11
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.4
9.1
64
284
J01DA01
ATC
[U] cefalexin
1.8
9.0
322
2495
N03AX16
ATC
[U] pregabalin
2.0
9.0
123
711
J01FA10
ATC
azithromycin; systemic
1.8
8.9
340
2685
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.5
8.9
57
242
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.7
8.8
28
79
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
8.7
107
594
D69.0
ICD-10 Finland
Allergic purpura
50.9
8.7
10
*
C01CA24
ATC
epinephrine; parenteral
2.6
8.7
54
226
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
16.6
8.6
13
8
Z31.5
ICD-10 Finland
Genetic counselling
2.6
8.4
50
204
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.8
8.4
172
1127
2BDXX, ,
NOMESCO Finland
+∞
8.4
8
*
3A149, ,
NOMESCO Finland
+∞
8.4
8
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
8.3
134
816
S06.0
ICD-10 Finland
Concussion
2.3
8.3
70
336
P01AB01
ATC
metronidazole; oral, rectal
1.7
8.3
228
1627
M25.5
ICD-10 Finland
Pain in joint
1.7
8.2
202
1395
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
8.2
212
1485
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
8.1
61
278
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.2
8.1
74
367
J01FA06
ATC
roxithromycin; oral
1.7
8.0
204
1422
J01FF01
ATC
clindamycin; systemic
1.8
7.9
139
868
Z3231
NOMESCO Finland
Registered nurse
1.8
7.9
147
935
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.0
7.9
34
117
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
7.9
111
646
R03AC02
ATC
salbutamol; inhalant
1.7
7.7
309
2426
D50.8
ICD-10 Finland
Other iron deficiency anaemias
8.2
7.6
16
20
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.9
7.6
108
628
J01MA02
ATC
ciprofloxacin; systemic
1.7
7.6
175
1180
M25.0
ICD-10 Finland
Haemarthrosis
10.2
7.6
14
14
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.7
7.6
41
160
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
7.4
47
199
D68.1
ICD-10 Finland
Hereditary factor XI deficiency
+∞
7.3
7
*
EBB10
NOMESCO Finland
Insertion of dental implant
6.7
7.2
17
26
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
3.0
7.1
31
107
SPAT1229
SPAT
Assessment of need for aid
2.8
7.1
36
136
M79.7
ICD-10 Finland
Fibromyalgia
3.0
7.0
31
108
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.3
7.0
55
256
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
7.0
43
179
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.9
7.0
32
114
R03BA02
ATC
budesonide; inhalant
1.9
7.0
106
630
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.5
7.0
46
198
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
7.0
103
607
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.0
6.9
83
455
R5140
NOMESCO Finland
Monitoring the use of the aid
2.3
6.9
55
257
J01AA02
ATC
doxycycline; systemic
1.8
6.9
383
3234
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.0
6.9
78
419
Z2221
NOMESCO Finland
Medical doctor
1.7
6.9
152
1009
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.6
6.9
292
2296
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
6.9
74
391
9981A
ICD-9 Finland
Other complications of procedures, not elsewhere classified, Haemorrhage or haematoma complicating a procedure
11.1
6.8
12
11
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
6.8
97
565
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.5
6.8
23
68
D69.8
ICD-10 Finland
Other specified haemorrhagic conditions
40.6
6.8
8
*
M54.5
ICD-10 Finland
Low back pain
1.7
6.7
199
1427
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
5.6
6.7
18
33
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.3
6.6
52
242
C07AA05
ATC
propranolol; systemic
1.8
6.6
124
785
R06AE07
ATC
cetirizine; oral
1.6
6.6
247
1875
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
6.6
113
696
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
6.6
190
1352
R01AD09
ATC
mometasone; nasal
1.6
6.5
261
2014
Z71.8
ICD-10 Finland
Other specified counselling
1.6
6.4
202
1467
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.4
6.4
45
200
A06AD11
ATC
lactulose; oral
2.1
6.4
60
301
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
6.3
63
323
N02BF02
ATC
pregabalin; oral
2.4
6.3
43
188
SPAT1104
SPAT
Monitoring of emergency patient
2.8
6.3
32
121
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
6.3
64
331
O991, D680,
ICD-10 Finland
+∞
6.3
6
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
6.3
156
1066
S93.4
ICD-10 Finland
Sprain and strain of ankle
1.9
6.2
78
434
N02CC04
ATC
rizatriptan; oral
2.3
6.2
45
203
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
6.1
51
244
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
204
7
488.73
219.44
6.0
1.3
84.49
152.71
%
—
193
7
284
547
10.65
162.49
3.9
1.9
30.71
28.95
s
5.66
272
528
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
71
14
58.90
125.19
1.4
1.0
114.89
138.93
%
1.06
64
14
66
14
54.13
114.45
1.2
1.0
94.07
96.38
%
—
28
8
64
15
48.75
108.47
1.3
1.1
100.96
108.00
%
—
28
9
269
1061
4.31
57.99
6.2
3.5
99.24
95.81
%
1.46
258
1035
201
643
4.55
57.60
4.4
3.3
0.82
0.82
mmol/l
0.22
196
612
49
0
+∞
51.99
1.6
0.0
52.00
—
%
—
43
0
115
317
4.41
38.56
2.9
2.4
84.80
74.45
ml/min/173m2
2.00
88
116
235
1061
3.28
37.28
3.4
1.8
0.59
0.93
mg/l
3.17
183
810
162
610
3.44
34.19
4.6
2.3
2.48
2.43
g/l
0.61
157
562
298
1734
2.77
27.16
5.5
4.3
37.50
36.71
g/l
1.76
282
1647
170
783
2.77
23.99
3.6
2.4
2.43
2.44
mmol/l
0.47
164
698
258
1498
2.49
22.11
3.7
3.0
2.37
2.36
mmol/l
0.51
247
1378
210
1146
2.43
20.17
4.5
2.1
2.67
2.80
mg/l
0.29
188
986
315
2191
2.18
15.44
5.7
5.7
10.98
10.12
umol/l
0.34
297
2085
418
3286
2.63
15.07
8.7
7.2
74.83
78.01
u/l
1.03
401
3128
354
2609
2.21
14.55
9.9
9.2
3.97
3.92
e9/l
0.19
327
2273
292
2014
2.08
14.11
7.3
6.3
1.22
1.22
mmol/l
0.05
255
1748
13
0
+∞
13.60
1.5
0.0
—
—
—
0
0
297
2085
2.04
13.38
13.4
10.0
0.01
0.00
e9/l
1.04
260
1695
413
3336
2.34
12.18
5.1
4.2
9.02
10.35
mm/h
1.47
395
3134
334
2498
2.01
11.97
5.3
3.2
88.70
78.35
ug/l
0.60
321
2366
259
1791
1.92
11.56
6.4
5.6
1.22
1.22
mmol/l
0.01
247
1664
153
905
1.99
10.68
2.4
2.5
6.90
7.88
e6/l
0.27
140
814
320
2425
1.88
10.24
4.8
4.2
6.21
6.46
mmol/l
1.71
306
2245
175
1134
1.83
9.00
2.9
2.9
0.28
0.32
e6/l
0.24
142
784
277
2099
1.71
7.97
3.7
2.6
—
—
estimate
—
0
0
200
1431
1.66
6.83
3.1
3.2
26.26
105.42
ng/l
0.80
114
841
272
2123
1.61
6.42
3.1
2.5
75.43
76.37
nmol/l
0.23
260
1963
186
1325
1.64
6.36
2.6
2.4
53.39
64.30
u/l
1.91
174
1234
66
350
2.02
6.04
5.5
7.6
5.21
5.14
kpa
0.21
66
337
478
4412
2.74
5.90
18.6
12.6
20.26
20.84
mg/l
0.13
435
3523
63
332
2.03
5.86
3.3
3.9
4.47
4.62
pmol/l
0.55
55
295
152
1057
1.63
5.60
3.0
2.0
—
—
—
0
0
97
600
1.76
5.52
2.3
1.8
—
—
—
0
0
63
341
1.97
5.44
5.6
7.8
0.89
1.07
mmol/l
0.12
52
287
82
485
1.83
5.41
6.6
5.3
1.05
1.06
mmol/l
0.12
77
452
418
3706
1.76
5.34
6.2
4.7
14.50
14.50
pmol/l
0.00
403
3475
179
1314
1.56
5.18
4.8
3.7
0.00
0.01
estimate
0.74
77
499
133
910
1.63
5.18
2.9
2.9
1186.35
779.96
ng/l
0.56
110
770
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
70
3.09
5.16
3.5
3.2
0.21
0.41
iu/ml
2.52
16
35
165
1206
1.55
4.81
1.9
1.7
—
—
—
0
0
39
185
2.20
4.77
7.8
6.8
24.80
24.87
mmol/l
0.05
39
177
455
4172
1.97
4.77
17.1
11.8
89.10
87.99
ml/min/173m2
0.56
434
3801
71
420
1.80
4.68
2.0
1.7
—
—
—
0
0
15
36
4.26
4.55
2.1
2.0
91.53
91.77
%
0.06
15
36
76
463
1.76
4.53
6.4
6.0
104.24
104.39
mmol/l
0.11
76
463
79
489
1.73
4.46
2.3
2.7
8.95
6.82
umol/l
0.18
66
426
56
313
1.89
4.41
4.2
3.6
1.23
1.23
mmol/l
0.03
49
265
339
2920
1.50
4.23
5.6
4.3
224.57
1315.90
e6/l
—
7
48
202
1577
1.47
4.17
3.0
3.0
27.66
28.88
u/l
0.35
192
1503
42
217
2.02
4.15
1.4
1.8
7.86
7.53
iu/ml
0.02
12
55
291
2438
1.46
4.14
4.6
3.6
0.00
3.14
estimate
0.50
79
518
232
1869
1.45
4.03
4.5
3.4
0.00
0.03
estimate
1.56
61
438
71
439
1.72
4.02
2.0
1.7
—
—
—
0
0
222
1781
1.44
3.90
2.1
2.0
103.84
97.55
pmol/l
0.89
116
926
378
3359
1.51
3.81
3.8
3.6
—
—
—
0
0
24
102
2.42
3.80
1.5
1.6
—
—
—
0
0
64
395
1.71
3.65
1.4
1.2
75.83
196.79
u/ml
1.26
59
371
286
2423
1.42
3.62
4.7
3.6
0.00
0.00
estimate
0.50
78
515
137
1014
1.48
3.62
3.1
2.6
317.83
315.92
umol/l
0.08
122
918
46
259
1.85
3.57
1.6
1.6
—
—
—
0
0
171
1327
1.44
3.52
1.4
1.4
0.60
1.72
u/ml
1.94
65
372
289
2463
1.41
3.48
4.7
3.7
0.00
0.02
estimate
1.08
77
495
454
4244
1.73
3.28
7.3
5.7
1.78
1.78
mu/l
0.04
434
4023
23
105
2.25
3.14
1.4
1.6
—
—
—
0
0
10
26
3.90
2.99
1.0
1.1
1868.30
1758.58
miu/ml
—
10
26
59
378
1.64
2.95
3.4
2.9
—
—
—
0
0
140
1078
1.41
2.94
4.9
3.5
1.02
1.02
kg/l
0.18
100
697
8
17
4.76
2.93
2.8
2.2
60.83
80.60
ug/l
—
8
17
72
486
1.56
2.90
2.3
1.9
—
—
—
0
0
84
588
1.51
2.87
2.4
2.0
—
—
—
0
0
21
96
2.24
2.87
2.7
2.6
2.33
2.20
index
0.04
12
50
125
949
1.42
2.83
1.4
1.3
32.10
13.86
u/ml
0.26
53
384
134
1032
1.41
2.79
1.5
1.3
24.81
29.57
iu/ml
0.16
39
315
19
85
2.28
2.74
2.6
3.2
6.83
7.99
pmol/l
0.29
19
85
53
337
1.64
2.73
2.5
2.3
5004.16
5579.44
u/l
0.06
19
150
18
79
2.33
2.70
1.3
1.2
6.63
1.46
u/ml
—
8
26
20
93
2.20
2.64
1.2
1.3
—
—
—
0
0
13
49
2.70
2.64
1.6
1.6
—
—
—
0
0
8
20
4.05
2.57
1.0
1.4
—
—
—
0
0
18
81
2.27
2.57
1.3
1.2
6.50
3.34
u/ml
—
10
32
33
187
1.82
2.56
1.5
1.4
—
—
—
0
0
97
717
1.44
2.53
3.4
3.2
431.98
277.46
ng/l
0.19
55
452
21
102
2.11
2.51
1.1
1.2
—
—
—
0
0
11
38
2.94
2.43
2.2
1.8
33.18
32.16
pg
0.41
11
38
48
311
1.60
2.32
3.6
3.6
72.54
69.51
ng/l
0.11
42
280
91
676
1.42
2.31
2.9
2.6
0.54
0.98
e6/l
2.05
53
324
174
1437
1.32
2.27
3.4
3.0
0.03
0.01
estimate
0.31
64
430
32
193
1.70
2.05
1.8
1.8
—
—
—
0
0
15
70
2.18
2.00
1.6
1.8
—
—
—
0
0
16
77
2.11
1.98
1.1
1.2
—
—
—
0
0
29
174
1.71
1.90
1.6
1.3
—
—
—
0
0
20
107
1.91
1.89
1.5
1.5
—
—
—
0
0
16
79
2.06
1.87
1.8
1.8
—
—
—
0
0
29
175
1.70
1.87
1.8
1.4
13.60
10.99
u/l
0.22
22
138
36
231
1.60
1.85
2.4
2.2
4.05
5.55
ug/l
0.39
31
205
6
17
3.56
1.84
3.8
2.6
0.83
0.76
index
—
6
17
83
632
1.38
1.83
2.9
2.7
2.00
3.44
e6/l
1.67
45
279
24
138
1.78
1.83
3.5
1.8
—
—
—
0
0
31
192
1.66
1.82
1.5
1.6
—
—
—
0
0
27
161
1.72
1.82
1.3
1.3
1.82
11.09
u/ml
—
5
30
345
3170
1.28
1.82
3.4
3.2
39.33
39.86
u/l
0.05
323
3037
63
458
1.43
1.81
1.3
1.2
157.53
143.96
u/ml
0.09
24
191
12
54
2.25
1.75
1.2
1.1
—
—
—
0
0
56
403
1.44
1.71
2.1
2.5
31.41
37.39
u/l
0.61
51
343
216
1893
1.25
1.66
1.9
1.9
1.52
1.33
mmol/l
2.09
187
1650
30
190
1.62
1.64
1.5
1.7
6.66
7.75
u/ml
—
7
50
18
98
1.87
1.63
1.6
1.4
—
—
—
0
0
8
33
2.45
1.54
2.0
1.7
—
—
—
0
0
6
21
2.88
1.51
1.0
1.5
—
—
—
0
0
27
171
1.61
1.49
1.4
1.5
1.09
1.24
g/l
1.90
27
166
45
320
1.45
1.48
4.0
6.5
1.13
1.23
mmol/l
0.50
45
314
22
132
1.70
1.48
3.4
1.7
—
—
—
0
0
26
164
1.62
1.46
1.4
1.6
0.20
0.24
g/l
1.83
26
159
56
416
1.39
1.46
1.6
1.4
21.54
25.60
iu/l
0.53
49
352
7
28
2.52
1.45
1.1
1.6
—
—
—
0
0
7
28
2.52
1.45
1.0
1.4
67.29
66.71
umol/l
—
7
28
7
28
2.52
1.45
2.0
1.6
—
—
—
0
0
7
28
2.52
1.45
2.0
1.6
—
—
—
0
0
7
28
2.52
1.45
2.0
1.6
—
—
—
0
0
56
418
1.38
1.42
6.2
5.4
—
—
—
0
0
9
40
2.27
1.40
1.9
1.6
—
—
—
0
0
7
29
2.43
1.39
1.0
2.2
—
1.06
—
0
8
5
17
2.96
1.36
1.8
4.1
138.60
963.35
mg
—
5
17
44
318
1.42
1.35
1.6
1.4
—
—
—
0
0
12
61
1.99
1.34
1.6
1.7
—
—
—
0
0
11
54
2.06
1.33
1.0
1.1
—
—
—
0
0
21
129
1.66
1.32
1.2
1.2
—
—
—
0
0
6
24
2.52
1.30
3.0
4.0
—
—
—
0
0
6
24
2.52
1.30
1.0
1.0
—
—
—
0
0
5
18
2.79
1.29
1.0
1.4
—
—
—
0
0
10
48
2.11
1.28
1.5
1.1
0.45
0.47
u/ml
—
5
19
109
908
1.26
1.28
2.5
2.2
—
—
—
0
0
18
107
1.71
1.27
1.7
1.9
121.46
262.64
ug/l
1.28
18
97
9
44
2.06
1.27
3.8
1.5
—
—
—
0
0
26
171
1.55
1.26
2.0
2.1
2.06
4.62
iu/l
2.21
11
69
449
4331
1.35
1.26
5.1
4.6
4.70
4.77
mmol/l
0.69
426
4107
15
85
1.79
1.24
1.9
4.5
1.59
2.84
ratio
—
10
49
11
56
1.99
1.23
1.4
1.1
—
—
—
0
0
5
19
2.65
1.22
1.0
1.1
—
—
—
0
0
5
19
2.65
1.22
1.0
1.1
—
—
—
0
0
136
1169
1.22
1.20
1.8
1.6
21.80
21.11
nmol/l
0.21
121
1008
492
4834
1.89
1.19
31.7
19.9
90.42
90.47
fl
0.09
492
4799
6
26
2.32
1.19
4.3
2.3
10.67
12.00
index
—
6
17
8
38
2.12
1.19
1.0
1.0
—
—
—
0
0
447
4316
1.33
1.18
5.0
4.5
1.48
1.53
mmol/l
2.17
422
4074
492
4835
1.88
1.18
32.0
20.2
40.26
40.23
%
0.04
492
4797
492
4835
1.88
1.18
31.9
19.9
4.48
4.48
e12/l
0.02
492
4753
10
50
2.02
1.17
1.2
1.1
—
—
—
0
0
451
4361
1.34
1.17
5.5
5.1
2.76
2.80
mmol/l
0.56
428
4125
35
250
1.43
1.16
2.4
3.1
5.02
5.06
kpa
0.12
29
244
5
20
2.51
1.15
1.0
1.0
—
—
—
0
0
492
4837
1.86
1.14
32.2
20.1
133.91
134.13
g/l
0.14
492
4801
425
4081
1.27
1.14
4.3
3.9
1.33
1.22
mmol/l
2.48
403
3832
14
80
1.77
1.14
1.6
1.4
—
—
—
0
0
10
51
1.98
1.12
1.3
1.5
—
—
—
0
0
430
4138
1.27
1.11
4.9
4.4
5.71
5.74
mmol/l
0.21
398
3860
30
212
1.44
1.06
2.6
3.1
1.59
1.33
mmol/l
0.13
19
153
20
130
1.56
1.04
1.3
1.2
—
—
—
0
0
7
34
2.07
1.03
1.3
1.2
—
—
—
0
0
23
155
1.51
1.03
1.4
1.4
—
—
—
0
0
99
837
1.23
1.03
2.6
2.1
—
—
—
0
0
7
35
2.01
1.00
1.0
1.1
93.43
114.80
pmol/l
—
7
35
9
49
1.85
0.99
1.0
1.1
—
—
—
0
0
9
49
1.85
0.99
3.4
2.9
27.21
38.78
u/ml
—
9
49
5
23
2.19
0.98
2.0
3.7
628.80
469.70
u/ml
—
5
23
10
54
1.87
0.97
1.1
1.1
100.90
95.76
%
—
10
49
10
54
1.87
0.97
1.4
1.1
—
—
—
0
0
14
85
1.67
0.95
1.5
1.4
—
—
—
0
0
34
252
1.37
0.95
1.7
1.6
—
—
—
0
0
6
27
2.24
0.93
1.2
1.6
—
—
—
0
0
18
119
1.53
0.89
2.4
2.1
9.84
10.22
g/l
0.16
18
111
8
44
1.83
0.86
1.0
1.1
—
—
—
0
0
68
565
1.24
0.84
1.9
1.6
1094.00
1169.60
nmol/l
0.31
55
426
37
285
1.32
0.83
1.4
1.4
—
—
—
0
0
11
65
1.71
0.83
1.1
1.3
—
—
—
0
0
153
1373
1.16
0.83
3.2
3.3
6.95
7.61
mmol/l
1.20
132
1202
8
46
1.75
0.83
1.0
1.1
—
—
—
0
0
8
46
1.75
0.83
1.0
1.1
—
—
—
0
0
23
164
1.42
0.81
1.2
1.4
149.00
155.56
pmol/l
0.02
23
159
18
122
1.49
0.81
1.5
1.3
297.60
322.96
ug/g
0.19
11
71
0
24
0.00
0.79
0.0
1.1
—
37.45
—
0
24
15
98
1.55
0.79
1.3
1.3
—
—
—
0
0
44
352
1.27
0.76
6.1
3.5
1.52
1.77
mmol/l
0.23
39
303
5
25
2.01
0.73
1.0
1.2
—
—
—
0
0
7
40
1.76
0.71
1.0
1.3
—
—
—
0
0
7
41
1.72
0.70
1.0
1.3
—
—
—
0
0
5
27
1.86
0.68
1.4
1.1
—
—
—
0
0
24
179
1.36
0.68
5.2
7.9
17.09
15.84
%
1.28
24
173
413
4009
1.17
0.66
6.1
5.4
37.70
38.09
mmol/mol
0.43
384
3822
19
137
1.40
0.65
2.4
2.1
3.20
3.94
g/l
1.60
19
130
19
137
1.40
0.65
2.4
2.1
4.06
4.36
g/l
1.25
19
130
19
137
1.40
0.65
2.4
2.1
6.77
7.44
g/l
1.01
19
130
18
129
1.41
0.64
2.5
2.2
2.79
3.00
g/l
0.81
18
122
25
190
1.33
0.64
2.8
2.6
1.46
1.23
%
0.45
25
190
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
29
1.73
0.64
1.2
1.1
—
—
—
0
0
12
79
1.53
0.63
1.4
1.4
155.20
154.32
au/ml
—
5
26
8
50
1.61
0.61
1.0
1.0
1.41
1.38
g/l
—
8
45
29
227
1.29
0.61
1.7
1.7
—
—
—
0
0
10
64
1.57
0.59
1.8
1.3
—
—
—
0
0
14
98
1.44
0.57
1.6
1.4
7129.00
9832.30
e6/l
—
6
67
70
611
1.17
0.55
1.5
1.6
1.46
1.37
%
0.48
61
552
24
186
1.30
0.55
2.8
2.6
0.64
0.63
%
0.06
24
186
9
61
1.48
0.54
2.0
1.4
—
—
—
0
0
11
74
1.50
0.53
1.3
1.3
—
—
—
0
0
11
74
1.50
0.53
1.3
1.3
—
—
—
0
0
11
74
1.50
0.53
1.2
1.1
—
—
—
0
0
15
108
1.40
0.53
2.5
2.2
0.00
0.05
g/l
0.50
15
101
16
118
1.37
0.50
2.8
2.5
1.06
0.61
g/l
0.34
16
108
7
45
1.56
0.49
1.3
1.1
—
72.20
—
0
5
40
469
0.84
0.46
3.9
4.3
28.16
32.79
%
1.63
25
327
13
95
1.38
0.44
1.1
1.2
140.00
231.03
u/ml
—
8
59
28
230
1.23
0.43
1.6
1.5
—
—
—
0
0
5
31
1.62
0.43
3.0
2.3
—
—
—
0
0
8
57
1.41
0.42
1.1
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
8
60
1.34
0.40
1.8
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
8
61
1.32
0.39
1.1
1.2
—
—
—
0
0
129
1203
1.10
0.38
4.0
4.1
7.08
8.73
mg/mmol
0.25
78
717
8
115
0.69
0.37
1.0
1.3
—
—
—
0
0
10
72
1.40
0.37
1.1
1.1
124.60
119.38
%
—
10
64
6
45
1.34
0.34
1.0
1.1
—
—
—
0
0
6
46
1.31
0.33
1.0
1.2
—
—
—
0
0
6
46
1.31
0.33
1.0
1.2
—
—
—
0
0
6
46
1.31
0.33
1.0
1.2
—
—
—
0
0
6
47
1.28
0.32
1.5
1.4
—
—
—
0
0
20
166
1.21
0.30
1.8
1.6
63.85
52.72
ug/l
0.59
20
166
7
56
1.25
0.29
2.1
1.7
11.97
73.81
u/ml
—
7
56
90
837
1.09
0.29
2.1
1.6
501.91
16872867.57
pmol/l
0.78
78
729
18
216
0.83
0.28
1.0
1.1
0.88
0.88
g/l
0.04
18
216
26
300
0.86
0.27
1.7
1.5
—
—
—
0
0
10
127
0.78
0.25
1.8
1.6
—
—
—
0
0
9
74
1.22
0.25
1.3
1.4
—
—
—
0
0
23
198
1.17
0.25
2.9
2.1
12.04
11.46
nmol/l
0.15
23
185
6
81
0.74
0.24
1.7
1.3
276.00
333.94
mu/l
—
6
66
18
211
0.85
0.23
1.0
1.1
1.48
1.58
g/l
0.80
18
211
50
458
1.10
0.23
1.8
1.6
786.75
997.10
mu/l
1.21
40
391
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
6
51
1.18
0.19
1.0
1.2
—
—
—
0
0
6
51
1.18
0.19
1.0
1.2
—
—
—
0
0
6
51
1.18
0.19
1.0
1.2
—
—
—
0
0
20
228
0.87
0.19
3.5
2.5
0.50
0.75
ug/l
1.81
15
116
28
251
1.12
0.19
1.3
1.3
110.01
246.21
miu/ml
2.33
13
135
7
58
1.21
0.18
1.1
1.1
—
14.00
—
0
27
33
301
1.10
0.17
1.1
1.0
—
—
—
0
0
25
225
1.12
0.16
1.8
1.5
0.19
0.28
mg/l
—
10
91
8
71
1.13
0.16
1.3
1.3
—
—
—
0
0
6
78
0.77
0.15
1.8
1.8
13.32
13.27
%
—
6
78
11
129
0.85
0.15
1.3
1.2
—
—
—
0
0
14
123
1.14
0.12
2.1
2.9
9.48
10.52
mg/l
0.46
14
116
25
269
0.93
0.10
1.7
1.6
58.87
62.78
ug/l
0.08
20
229
38
359
1.06
0.10
2.6
4.3
3.50
20.56
ug/l
0.76
29
282
10
87
1.15
0.09
3.3
2.4
—
—
—
0
0
22
237
0.92
0.09
1.5
1.8
4.09
2.90
mg/l
0.28
17
175
11
97
1.14
0.09
1.1
1.1
0.96
2.06
eliau/ml
—
5
50
23
214
1.08
0.08
3.0
2.8
126.83
131.07
g/l
0.40
23
209
21
195
1.08
0.08
2.1
1.8
—
—
—
0
0
28
297
0.94
0.08
4.1
3.8
24.21
22.53
%
0.25
16
115
116
1136
1.03
0.07
1.7
1.5
—
—
—
0
0
49
474
1.04
0.06
1.6
1.7
3.34
3.35
mmol/l
0.04
38
336
16
153
1.05
0.01
1.3
1.1
1.57
1.74
u/ml
0.05
11
81
62
613
1.01
0.01
1.7
1.9
3.54
3.29
ratio
0.76
49
471
19
196
0.97
0.00
1.3
1.9
—
—
—
0
0
24
246
0.97
0.00
1.7
1.5
1.03
0.95
ratio
0.71
17
160
24
246
0.97
0.00
1.7
1.5
1.16
1.19
ratio
0.03
17
160
24
246
0.97
0.00
1.7
1.5
1.00
1.20
ratio
0.82
17
160
24
243
0.99
0.00
1.7
1.5
—
—
—
0
0
13
129
1.01
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
76.80
—
0
5
0
8
0.00
0.00
0.0
1.1
—
1.20
—
0
8
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_VONVILLEBRAND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_VONVILLEBRAND | 1.504 [1.17, 1.94] | 0.002 |
| Birth year | 0.996 [0.99, 1.0] | 0.303 |
During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 1902 females with D3_VONVILLEBRAND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_VONVILLEBRAND | 1.609 [1.22, 2.12] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 821 males with D3_VONVILLEBRAND died.
Mortality risk
Mortality risk for people of age
years, who have D3_VONVILLEBRAND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | 0.35% |
| 5 | 0.906% | 2.071% |
| 10 | 2.221% | 5.037% |
| 15 | 4.34% | 9.326% |
| 20 | 7.565% | 15.692% |
Relationships between endpoints
↥Index endpoint: D3_VONVILLEBRAND – Von Willebrand disease
GWS hits: 12
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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