≡ Risteys
R14

Documentation Changelog GitHub Contact & Feedback

Congenital malformations of eyelid, lacrimal apparatus and orbit

EFO Endpoint Browser PheWeb

Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q10
  • Cause of death: ICD-10 — Q10

2 out of 7 registries used, show all original rules.

363

4. Check minimum number of events

None

363

5. Include endpoints

None

363

6. Filter based on genotype QC (FinnGen only)

329

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q1
Name in latin
Malformationes congenitae palpebrarum, apparatus lacrimalis et orbitae

Similar endpoints

↥

List of similar endpoints to Congenital malformations of eyelid, lacrimal apparatus and orbit based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12033 5863 6168
Only index persons 7548 3712 3836
Unadjusted period prevalence (%)
Whole population 0.17 0.17 0.17
Only index persons 0.14 0.14 0.15
Median age at first event (years)
Whole population 1.30 1.32 1.26
Only index persons 1.36 1.40 1.32

-FinnGen-

Key figures

All Female Male
Number of individuals 329 200 129
Unadjusted period prevalence (%) 0.07 0.07 0.06
Median age at first event (years) 3.21 2.29 4.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
343
Matched controls
3429
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q10.5
ICD-10 Finland
Congenital stenosis and stricture of lacrimal duct
974.3
204.6
181
*
Q10.0
ICD-10 Finland
Congenital ptosis
+∞
145.4
129
*
H02.4
ICD-10 Finland
Ptosis of eyelid
47.3
98.5
59
15
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
418.1
96.1
92
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
23.1
54.8
41
20
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
137.7
35.4
37
*
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
317.4
29.2
29
*
CBJ10
NOMESCO Finland
Fascia plate sling or synthetic material for ptosis correction
+∞
25.3
24
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
18.6
145
713
74482
ICD-8 Finland
Congenital anomalies of eye, Ptosis
+∞
17.9
17
*
Q10.30
ICD-10 Finland
Other congenital malformations of eyelid
+∞
17.9
17
*
ZXA10
NOMESCO Finland
Bilateral
2.9
14.5
82
334
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
72.6
12.7
14
*
ZXE00
NOMESCO Finland
One hour or less
2.2
11.3
145
853
XCK10
NOMESCO Finland
Photography of fundus of eye
3.9
10.9
34
95
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
113.3
10.5
11
*
Q10.2
ICD-10 Finland
Congenital entropion
+∞
10.5
10
*
ZXA00
NOMESCO Finland
Right side
2.6
9.9
67
296
ZXA05
NOMESCO Finland
Left side
2.6
9.7
63
273
3242
FHL
Levator resection
+∞
9.4
9
*
S01AA01
ATC
chloramphenicol; ophthalmic
4.6
9.2
22
50
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
9.2
102
558
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
24.8
9.0
12
5
ZXD20
NOMESCO Finland
Day surgery
2.8
8.7
46
179
CBJ99
NOMESCO Finland
Other operation for ptosis
+∞
8.4
8
*
7436B
ICD-9 Finland
Congenital anomalies of eyelids, lachrymal system and orbit[PTOSIS CONGENITA]
+∞
8.4
8
*
H02.3
ICD-10 Finland
Blepharochalasis
6.8
8.3
20
31
S01AX11
ATC
[U] ofloxacin
4.9
8.2
18
38
H53.0
ICD-10 Finland
Amblyopia ex anopsia
6.6
8.1
20
32
WX400
NOMESCO Finland
Inhalation anesthesy
3.3
7.6
29
93
3743A
ICD-9 Finland
Other disorders of eyelids, Ptosis of eyelid[PTOSIS]
+∞
7.3
7
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.0
6.3
18
47
Q10.1
ICD-10 Finland
Congenital ectropion
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
257
1.82
3.13
1.6
1.6
968.09
1128.05
nmol/l
0.70
35
188
45
271
1.76
2.90
1.4
1.4
230.54
638.01
u/ml
0.65
39
257
316
2947
1.91
2.73
12.5
9.9
—
—
—
0
0
48
301
1.69
2.69
1.4
1.6
—
—
—
0
0
150
1214
1.42
2.57
3.1
3.1
72.05
69.54
nmol/l
0.51
139
1134
34
198
1.80
2.46
1.8
2.1
14.33
13.53
iu/l
0.06
28
157
104
804
1.42
2.26
1.9
1.9
—
—
—
0
0
139
1130
1.39
2.25
9.6
12.0
1.22
1.23
mmol/l
1.67
129
1063
307
2870
1.66
2.21
13.7
12.9
24.39
21.67
mg/l
0.59
244
2197
9
33
2.77
1.94
1.0
1.0
—
—
—
0
0
247
2236
1.37
1.87
4.1
3.9
14.62
14.55
pmol/l
0.15
223
2028
133
1099
1.34
1.87
6.8
8.9
—
—
—
0
0
31
192
1.68
1.85
8.5
16.9
7.38
7.42
ph
0.91
17
101
84
649
1.39
1.80
3.7
4.1
7.39
7.39
ph
0.00
51
463
174
1508
1.31
1.72
6.0
7.3
6.07
6.13
mmol/l
0.18
165
1387
32
205
1.62
1.69
2.3
1.9
6.13
6.31
ph
0.41
19
128
184
1609
1.31
1.69
3.9
3.5
67.09
65.14
ug/l
0.10
176
1527
12
55
2.22
1.69
3.1
13.7
0.83
0.84
%
0.02
12
50
205
1823
1.31
1.65
6.9
7.1
90.07
91.56
u/l
0.13
199
1725
29
183
1.64
1.63
1.8
2.2
6.75
6.95
u/l
0.05
23
136
77
597
1.37
1.61
2.9
3.0
7.62
8.69
e6/l
0.24
70
540
30
192
1.62
1.60
8.7
16.7
14.11
13.81
kpa
0.09
30
187
30
192
1.62
1.60
8.7
16.7
5.28
5.20
kpa
0.14
30
186
105
856
1.33
1.58
7.4
8.8
1.12
1.14
inr
0.31
92
716
74
574
1.37
1.54
5.8
4.5
—
—
—
0
0
283
2649
1.39
1.51
15.4
14.6
139.62
139.50
mmol/l
0.41
278
2587
128
1080
1.29
1.49
4.8
4.8
61.85
92.21
e6/l
0.26
96
708
96
780
1.32
1.47
3.2
2.4
2.52
2.53
mg/l
0.02
89
677
41
288
1.48
1.47
10.0
13.9
105.02
105.10
mmol/l
0.04
41
288
38
265
1.49
1.42
1.3
1.3
—
—
—
0
0
107
887
1.30
1.42
2.2
1.8
97.79
95.77
pmol/l
0.17
64
468
243
2236
1.30
1.38
4.1
4.0
2.70
2.63
mmol/l
0.66
230
2120
184
1638
1.27
1.36
7.8
8.9
0.23
0.20
e9/l
0.98
164
1424
49
363
1.41
1.35
2.1
1.7
—
—
—
0
0
169
1492
1.26
1.33
7.4
8.4
0.62
0.63
%
0.16
164
1417
90
735
1.30
1.33
2.5
2.8
50.26
63.16
u/l
1.26
84
673
20
122
1.68
1.30
10.9
20.0
0.67
0.65
%
0.05
20
122
196
1766
1.26
1.28
9.9
11.0
3.90
3.85
e9/l
0.09
174
1506
140
1217
1.25
1.24
5.7
7.4
16.90
17.35
umol/l
0.05
130
1140
24
156
1.58
1.24
1.3
1.2
—
—
—
0
0
184
1652
1.24
1.22
7.6
8.2
2.24
2.21
e9/l
0.09
165
1454
42
309
1.41
1.21
10.8
10.5
—
—
—
0
0
83
679
1.29
1.20
2.7
3.0
20.74
33.50
ng/l
0.64
42
350
106
895
1.27
1.20
4.1
4.1
8.08
117.02
e6/l
0.84
87
668
142
1244
1.24
1.16
9.3
11.2
1.21
1.22
mmol/l
1.17
128
1110
5
20
2.52
1.15
1.2
1.3
—
—
—
0
0
67
536
1.31
1.15
2.6
3.4
1.14
1.34
mg/l
0.25
41
388
177
1593
1.23
1.11
7.7
8.3
0.04
0.04
e9/l
0.63
158
1356
177
1593
1.23
1.11
7.7
8.3
0.60
0.56
e9/l
0.96
158
1360
13
74
1.79
1.08
2.2
1.6
1.45
4.49
u/ml
—
8
50
110
945
1.24
1.06
6.3
7.3
—
—
—
0
0
95
803
1.25
1.06
3.9
3.9
0.43
0.36
e6/l
0.07
76
577
222
2053
1.23
1.04
3.3
3.3
1.16
1.18
mmol/l
0.17
208
1940
35
257
1.40
1.04
1.2
1.2
—
—
—
0
0
29
206
1.44
1.02
6.0
7.5
68.17
61.99
ng/l
0.16
24
194
50
392
1.32
0.99
12.4
18.0
24.90
24.58
mmol/l
0.41
50
392
240
2243
1.23
0.99
3.8
3.7
4.44
4.43
mmol/l
0.04
227
2136
67
809
0.79
0.99
2.1
1.8
—
—
—
0
0
133
1174
1.22
0.98
3.0
3.3
—
—
estimate
—
0
0
9
50
1.82
0.97
6.8
3.9
9.44
9.05
kpa
—
9
50
9
50
1.82
0.97
6.8
3.9
5.27
4.80
kpa
—
9
50
11
62
1.80
0.95
3.2
12.3
1.55
1.51
%
0.10
11
57
329
3210
1.60
0.94
21.5
19.1
265.24
262.59
e9/l
0.32
323
3133
25
176
1.45
0.93
1.1
1.2
0.94
1.03
u/ml
0.04
16
105
11
63
1.77
0.91
1.8
1.8
—
—
—
0
0
11
63
1.77
0.91
1.8
1.8
—
—
—
0
0
11
63
1.77
0.91
1.8
1.8
—
—
—
0
0
11
63
1.77
0.91
1.8
1.8
—
—
—
0
0
268
2545
1.24
0.89
5.2
4.8
1.89
1.90
mu/l
0.02
252
2394
8
42
1.93
0.89
3.3
4.3
4.66
5.59
pmol/l
—
8
42
11
64
1.74
0.87
6.0
3.8
7.40
7.41
ph
0.43
11
64
27
197
1.40
0.85
1.2
1.2
0.08
2.91
u/ml
3.24
17
129
6
31
1.95
0.84
4.0
3.3
5.63
6.34
mmol/l
—
6
31
329
3216
1.56
0.84
21.4
19.0
4.61
4.59
e12/l
0.34
322
3138
45
357
1.30
0.84
2.5
2.4
2757.09
4647.20
u/l
0.27
14
116
329
3217
1.55
0.83
21.5
19.1
6.94
6.90
e9/l
0.09
322
3137
236
2222
1.20
0.81
3.8
3.7
1.37
1.42
mmol/l
1.19
224
2101
135
1213
1.19
0.80
4.0
3.2
6.50
6.27
ph
1.47
65
634
7
123
0.56
0.79
1.9
1.8
—
—
—
0
0
70
591
1.23
0.79
1.7
1.5
16.04
20.64
nmol/l
2.80
59
512
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
0
27
0.00
0.77
0.0
1.0
—
—
—
0
0
47
380
1.27
0.77
10.7
9.8
7.40
7.41
ph
0.08
40
309
43
344
1.29
0.76
2.3
2.1
—
—
—
0
0
13
196
0.65
0.76
2.1
2.3
—
14.11
—
0
15
52
427
1.26
0.75
1.3
1.2
—
—
—
0
0
7
38
1.86
0.74
3.0
2.4
0.36
4.46
u/ml
—
7
38
123
1104
1.18
0.73
1.6
1.6
1.08
2.47
u/ml
1.06
27
243
47
383
1.26
0.73
11.0
9.8
5.20
5.08
kpa
0.54
47
373
5
25
2.01
0.73
1.0
1.0
—
—
—
0
0
9
56
1.62
0.73
1.0
1.1
—
—
—
0
0
9
56
1.62
0.73
6.4
4.2
—
—
—
0
0
17
118
1.46
0.70
1.1
1.1
0.04
0.44
u/ml
—
8
53
5
27
1.86
0.68
1.6
1.1
—
—
—
0
0
5
95
0.52
0.67
1.0
1.5
—
—
—
0
0
7
43
1.64
0.67
3.1
3.3
—
—
—
0
0
5
28
1.80
0.66
2.0
2.9
473.60
1138.96
u/ml
—
5
28
48
400
1.23
0.63
6.0
10.4
1.35
0.96
mmol/l
0.40
38
315
104
932
1.17
0.62
2.3
2.3
—
—
—
0
0
23
174
1.34
0.61
1.2
1.2
5.73
1.98
u/ml
0.33
17
119
8
50
1.61
0.61
1.4
3.9
42.21
35.57
%
—
8
50
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
181.07
—
0
22
14
195
0.71
0.58
1.5
1.4
—
—
—
0
0
6
35
1.73
0.58
1.0
1.1
—
—
—
0
0
43
359
1.23
0.56
3.7
5.0
6.14
7.95
umol/l
0.48
35
301
6
37
1.63
0.56
1.3
2.1
—
—
—
0
0
8
122
0.65
0.56
1.4
1.5
—
—
—
0
0
92
825
1.16
0.55
2.9
3.1
—
—
—
0
0
38
314
1.24
0.55
12.0
10.5
9.03
9.44
kpa
0.75
38
305
30
241
1.27
0.54
1.5
1.5
—
—
—
0
0
6
39
1.55
0.53
1.0
2.4
—
—
—
0
0
10
66
1.53
0.53
2.5
2.7
1.60
4.95
index
—
5
39
75
842
0.86
0.53
4.1
3.8
8.52
8.37
mmol/l
0.08
68
758
6
40
1.51
0.52
4.0
3.0
1.18
1.29
mmol/l
—
6
40
11
75
1.48
0.51
4.1
3.2
108.91
393.04
ug/l
1.49
11
67
82
735
1.15
0.49
4.7
3.0
1.01
1.02
kg/l
1.44
57
463
8
120
0.66
0.46
1.4
1.4
—
—
—
0
0
8
120
0.66
0.46
1.5
1.4
—
—
—
0
0
43
368
1.19
0.45
1.7
1.6
514.68
20552595.37
pmol/l
0.50
37
326
15
112
1.35
0.45
1.0
1.1
1.45
1.49
g/l
0.33
15
112
15
112
1.35
0.45
1.0
1.1
—
0.47
—
0
10
15
113
1.34
0.43
1.0
1.1
0.88
0.80
g/l
0.78
15
113
231
2222
1.12
0.42
4.1
3.5
5.53
5.57
mmol/l
0.18
211
2054
26
213
1.24
0.42
1.7
1.9
0.00
0.00
estimate
—
6
55
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
47
410
1.17
0.41
6.1
10.3
7.37
7.37
ph
0.60
33
274
5
34
1.48
0.40
2.0
2.1
—
—
—
0
0
66
592
1.14
0.40
2.9
2.7
136.11
97.91
ug/g
0.31
53
466
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
11
80
1.39
0.39
1.0
1.1
—
—
—
0
0
59
527
1.14
0.38
2.9
3.0
576.41
552.54
mosm/kgh2o
0.31
53
465
8
112
0.71
0.38
1.4
1.4
1.52
1.24
mm
—
8
86
32
273
1.19
0.36
1.3
1.3
—
—
—
0
0
34
292
1.18
0.36
1.3
1.2
—
41.50
—
0
10
12
90
1.35
0.36
4.3
8.5
—
—
—
0
0
6
41
1.47
0.36
6.7
3.7
3.77
3.86
mmol/l
—
6
41
5
80
0.62
0.35
1.4
2.2
—
—
—
0
0
109
1016
1.11
0.35
1.7
1.6
—
—
—
0
0
28
329
0.84
0.35
2.1
2.4
—
—
—
0
0
22
181
1.23
0.35
13.8
18.9
1.08
1.14
mg/l
0.37
22
173
32
274
1.18
0.35
1.4
1.3
42.89
158.66
u/ml
—
9
91
51
454
1.14
0.35
1.3
1.3
13.83
24.95
iu/ml
1.23
13
112
69
756
0.89
0.35
2.1
2.0
—
—
—
0
0
157
1494
1.09
0.33
10.5
11.5
0.00
0.00
e9/l
0.40
129
1183
64
702
0.89
0.33
5.7
5.1
—
—
—
0
0
6
46
1.31
0.33
1.7
1.4
0.63
0.49
e9/l
—
6
46
6
47
1.28
0.32
1.2
1.2
—
—
—
0
0
7
52
1.35
0.31
1.0
1.1
—
—
—
0
0
14
173
0.80
0.29
5.4
4.2
7.37
7.32
ph
—
8
124
36
318
1.15
0.28
1.8
1.6
—
—
—
0
0
8
65
1.24
0.27
1.5
1.2
—
—
—
0
0
15
182
0.82
0.27
1.9
1.5
0.20
0.28
mg/l
—
6
77
44
485
0.89
0.25
5.0
4.4
6.31
45.83
mg/mmol
0.59
30
323
14
114
1.24
0.25
1.1
2.0
0.00
0.00
estimate
—
5
41
9
77
1.17
0.24
2.1
1.8
0.45
0.60
nmol/l
—
9
67
40
361
1.12
0.24
10.5
13.3
—
—
—
0
0
37
410
0.89
0.24
1.5
1.4
560.00
449.86
titre
—
9
73
154
1482
1.07
0.23
4.5
3.6
0.00
0.00
estimate
-0.00
30
316
7
91
0.76
0.22
1.0
1.5
—
70.59
—
0
17
12
146
0.82
0.22
2.6
1.8
113.83
170.28
u/ml
—
7
81
84
791
1.08
0.22
3.7
2.5
—
—
—
0
0
46
421
1.11
0.22
1.3
1.2
12.65
6.26
u/ml
0.23
15
153
25
283
0.87
0.22
2.6
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
4.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
18.5
—
0.64
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
28.11
—
0
10
0
10
0.00
0.21
0.0
1.0
—
159.30
—
0
10
0
10
0.00
0.21
0.0
1.9
—
123.60
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
8
104
0.76
0.21
1.5
2.8
52.39
54.35
%
—
8
104
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
62.25
—
0
12
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.7
—
241.08
—
0
13
104
991
1.07
0.20
1.7
1.6
1.84
1.89
g/l
0.17
62
567
10
80
1.26
0.20
14.8
5.2
36.98
36.99
°c
—
10
80
32
288
1.12
0.20
5.2
4.7
1.61
1.65
ug/l
0.03
26
254
0
14
0.00
0.20
0.0
4.4
—
—
—
0
0
51
474
1.09
0.19
4.1
4.1
4.75
3.33
e6/l
0.30
30
234
152
1472
1.06
0.18
4.4
3.5
0.00
0.00
estimate
-0.00
30
321
22
247
0.88
0.18
3.4
3.5
—
—
—
0
0
8
69
1.16
0.16
1.1
1.2
—
3.75
—
0
11
113
1088
1.06
0.16
4.3
3.1
0.00
0.01
estimate
0.80
22
269
17
149
1.15
0.16
1.5
1.6
—
—
—
0
0
14
161
0.86
0.15
1.3
1.5
54.78
63.50
ug/l
0.27
14
141
30
327
0.91
0.15
1.6
1.6
1046.94
927.70
mu/l
0.44
30
298
13
112
1.17
0.14
1.2
1.5
—
—
—
0
0
43
459
0.93
0.14
1.6
1.9
—
—
—
0
0
87
905
0.95
0.14
2.1
1.9
1.33
1.27
mmol/l
0.31
79
813
13
149
0.87
0.14
3.0
4.4
2.20
40.06
ug/l
—
8
108
43
458
0.93
0.14
1.6
1.9
—
—
—
0
0
153
1491
1.05
0.14
4.6
3.6
0.00
0.00
estimate
-0.00
27
307
8
99
0.80
0.14
3.0
1.3
—
—
—
0
0
44
413
1.07
0.13
3.5
3.8
339.70
436.76
ng/l
0.16
20
237
23
209
1.11
0.13
4.2
4.7
0.67
0.49
%
—
9
60
43
457
0.93
0.13
1.6
1.9
—
—
—
0
0
45
476
0.94
0.12
4.2
3.8
32.72
89.74
mg/l
1.58
31
327
15
133
1.13
0.12
7.2
13.2
0.71
0.62
%
0.73
15
133
28
259
1.09
0.12
1.4
1.4
3.44
3.17
mmol/l
0.51
16
165
25
230
1.09
0.12
2.8
5.8
74.44
70.37
e9/l
0.18
20
158
59
565
1.05
0.10
1.5
1.7
—
—
—
0
0
36
339
1.07
0.10
3.0
2.9
4.52
4.43
e9/l
0.05
29
306
44
461
0.95
0.09
1.6
1.9
—
—
—
0
0
6
54
1.11
0.09
1.3
1.4
22.80
14.14
u/l
—
6
47
6
57
1.05
0.08
3.0
3.5
19.38
70.27
u/ml
—
6
57
5
62
0.80
0.08
8.0
8.0
—
—
—
0
0
32
337
0.94
0.08
1.5
1.6
—
—
—
0
0
205
2025
1.03
0.07
4.9
4.5
36.40
36.67
mmol/mol
0.20
197
1921
8
75
1.07
0.07
1.0
1.9
15.25
20.20
ng/l
—
8
75
16
172
0.93
0.06
1.3
1.1
—
—
—
0
0
18
192
0.93
0.05
1.8
2.5
—
—
—
0
0
10
90
1.11
0.05
1.1
1.2
—
—
—
0
0
13
120
1.09
0.05
1.2
1.1
—
32.65
—
0
26
11
101
1.09
0.04
1.9
2.2
—
—
—
0
0
42
432
0.97
0.04
1.6
1.9
—
—
—
0
0
13
121
1.08
0.03
1.0
1.0
6.99
8.35
mu/l
0.48
13
113
15
159
0.94
0.03
2.5
2.7
0.68
0.67
ug/l
—
7
94
10
92
1.09
0.03
1.5
1.1
—
—
—
0
0
85
839
1.02
0.02
3.3
2.9
0.00
0.00
estimate
0.50
23
262
79
780
1.02
0.02
4.5
3.5
0.00
0.00
estimate
-0.00
28
302
110
1108
0.99
0.01
2.4
2.4
—
—
—
0
0
22
214
1.03
0.00
5.6
5.4
0.13
0.09
%
—
8
54
23
224
1.03
0.00
5.4
5.4
0.00
0.04
%
—
8
55
10
98
1.02
0.00
1.4
1.3
—
—
—
0
0
10
98
1.02
0.00
1.4
1.3
—
—
—
0
0
10
96
1.04
0.00
1.0
1.2
—
—
—
0
0
10
95
1.05
0.00
1.0
1.2
—
1.62
—
0
6
10
95
1.05
0.00
1.0
1.0
—
—
—
0
0
11
114
0.96
0.00
1.0
1.2
—
—
—
0
0
29
287
1.01
0.00
1.2
1.2
—
—
—
0
0
22
215
1.02
0.00
1.3
1.4
186.93
262.30
miu/ml
0.49
12
112
17
168
1.01
0.00
1.0
1.0
—
—
—
0
0
12
117
1.03
0.00
1.7
1.8
—
—
—
0
0
37
367
1.01
0.00
1.6
2.0
—
—
—
0
0
10
99
1.01
0.00
1.0
1.1
—
—
—
0
0
22
225
0.98
0.00
5.8
5.3
1.13
0.76
%
—
8
66
84
838
1.00
0.00
1.7
1.8
—
—
—
0
0
12
115
1.04
0.00
1.2
1.3
0.21
0.22
g/l
0.07
12
110
0
6
0.00
0.00
0.0
4.5
—
10.83
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
0.00
1.3
3.9
—
—
—
0
0
5
50
1.00
0.00
2.6
13.5
1.34
1.17
mmol/l
—
5
42
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
0.00
1.4
1.7
186.60
212.50
pmol/l
—
5
54
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
152.67
—
0
9
7
75
0.93
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
86.84
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
-0.00
1.8
2.4
139.38
130.74
g/l
—
8
65
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.4
—
138.86
—
0
7
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.7
—
0.56
—
0
7
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.9
—
29.14
—
0
7
5
54
0.92
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
-0.00
1.8
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
197.00
—
0
5
7
70
1.00
-0.00
1.0
1.2
—
3.34
—
0
8
5
49
1.02
-0.00
1.4
4.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT and mortality.

Females

Parameter HR [95% CI] p-value
Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT 1.242 [0.85, 1.81] 0.263
Birth year 1.0 [0.99, 1.01] 0.939

During the follow-up period (1.1.1998 — 31.12.2019), 61 out of 5131 females with Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT died.

Males

Parameter HR [95% CI] p-value
Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT 1.42 [1.06, 1.9] 0.018
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 5456 males with Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT died.

Mortality risk

Mortality risk for people of age

years, who have Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT.

N-year risk Females Males
1 0.099% 0.215%
5 0.743% 1.521%
10 2.266% 4.077%
15 4.051% 7.793%
20 7.108% 12.713%

Relationships between endpoints

↥

Index endpoint: Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT – Congenital malformations of eyelid, lacrimal apparatus and orbit

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data