Congenital malformations of eye, ear, face and neck

Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q10-Q18
  • Cause of death: ICD-10 Q10-Q18

2 out of 7 registries used, show all original rules.

3011

4. Check minimum number of events

None

3011

5. Include endpoints

3011

6. Filter based on genotype QC (FinnGen only)

2719

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q
Name in latin
Malformationes congenitae oculorum, aurium, faciei et colli

Similar endpoints

List of similar endpoints to Congenital malformations of eye, ear, face and neck based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 42386 21671 20654
Only index persons 33417 17407 16010
Unadjusted period prevalence (%)
Whole population 0.60 0.62 0.58
Only index persons 0.63 0.64 0.61
Median age at first event (years)
Whole population 6.75 7.53 5.86
Only index persons 11.62 13.48 9.60

-FinnGen-

Key figures

All Female Male
Number of individuals 2719 1715 1004
Unadjusted period prevalence (%) 0.55 0.61 0.46
Median age at first event (years) 32.76 29.10 39.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2845
Matched controls
28446
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q18.0
ICD-10 Finland
Sinus, fistula and cyst of branchial cleft
+∞
307.7
710
*
Q18.8
ICD-10 Finland
Other specified congenital malformations of face and neck
+∞
307.7
336
*
Q17.5
ICD-10 Finland
Prominent ear
4537.3
307.7
403
*
ENB40
NOMESCO Finland
Excision of branchial cyst or fistula
1639.8
307.7
419
*
DAD30
NOMESCO Finland
Plastic repair of auricle
+∞
307.7
369
*
Q13.2
ICD-10 Finland
Other congenital malformations of iris
2625.2
263.5
251
*
Q18.1
ICD-10 Finland
Preauricular sinus and cyst
+∞
199.3
189
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
6.3
180.8
327
575
Q10.5
ICD-10 Finland
Congenital stenosis and stricture of lacrimal duct
324.4
180.3
181
6
Q12.0
ICD-10 Finland
Congenital cataract
+∞
178.0
169
*
ENB50
NOMESCO Finland
Excision of cyst or fistula of thyroglossic duct
300.7
167.7
169
6
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
31.0
146.5
96
32
Q10.0
ICD-10 Finland
Congenital ptosis
447.6
130.0
129
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.0
91.5
275
733
Q14.10
ICD-10 Finland
Congenital retinoschis
800.2
79.8
78
*
Q16.1
ICD-10 Finland
Congenital absence, atresia and stricture of auditory canal (external)
726.3
72.5
71
*
Q17.2
ICD-10 Finland
Microtia
+∞
72.2
69
*
DAB20
NOMESCO Finland
Closure of preauricular fistula
+∞
64.8
62
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
54.7
780
4506
H27.0
ICD-10 Finland
Aphakia
20.8
54.0
41
20
Q14.2
ICD-10 Finland
Congenital malformation of optic disc
+∞
52.2
50
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
10.2
50.5
57
57
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
49.9
1011
6523
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
6.8
48.9
77
116
ZXA10
NOMESCO Finland
Bilateral
2.1
46.1
510
2666
Q15.0
ICD-10 Finland
Congenital glaucoma
+∞
44.9
43
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
43.2
910
5888
ZXA00
NOMESCO Finland
Right side
1.9
41.2
603
3469
DAD10
NOMESCO Finland
Reconstruction of auricle
413.4
41.2
41
*
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
10.6
41.1
45
43
L02.1
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of neck
7.2
39.9
59
83
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
8.0
39.2
53
67
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
8.1
38.9
52
65
Q14.8
ICD-10 Finland
Other congenital malformations of posterior segment of eye
+∞
36.5
35
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
5.2
34.2
71
140
H02.4
ICD-10 Finland
Ptosis of eyelid
4.0
33.7
97
249
Q16.0
ICD-10 Finland
Congenital absence of (ear) auricle
+∞
32.3
31
*
Q18.9
ICD-10 Finland
Congenital malformation of face and neck, unspecified
+∞
32.3
31
*
L04.0
ICD-10 Finland
Acute lymphadenitis of face, head and neck
4.8
31.6
72
154
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
30.6
411
2279
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.3
30.3
249
1147
Z3229
NOMESCO Finland
Other healthcare associate professional
2.3
30.3
247
1134
Q18.2
ICD-10 Finland
Other branchial cleft malformations
+∞
30.3
29
*
S01ED01
ATC
timolol; ophthalmic
4.0
30.1
87
224
ZXA05
NOMESCO Finland
Left side
1.8
29.9
523
3153
Q16.3
ICD-10 Finland
Congenital malformation of ear ossicles
+∞
29.2
28
*
Q17.3
ICD-10 Finland
Other misshapen ear
+∞
29.2
28
*
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
10.1
29.2
33
33
H53.0
ICD-10 Finland
Amblyopia ex anopsia
4.5
27.6
68
155
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
7.6
26.3
37
49
DAB00
NOMESCO Finland
Excision of lesion of auricle
7.2
26.3
39
55
CBJ10
NOMESCO Finland
Fascia plate sling or synthetic material for ptosis correction
+∞
25.0
24
*
Q13.0
ICD-10 Finland
Coloboma of iris
+∞
25.0
24
*
UDC00
NOMESCO Finland
Ear microscopy
2.1
24.8
238
1166
ZXE00
NOMESCO Finland
One hour or less
1.5
24.1
1019
7612
Q14.18
ICD-10 Finland
Congenital malformation of retina
+∞
24.0
23
*
XCK00
NOMESCO Finland
Perimetry
2.6
24.0
139
545
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
6.8
23.8
37
55
Q89.23
ICD-10 Finland
Cyst of the ductus thyreoglossus
33.7
23.3
30
9
S01EC01
ATC
acetazolamide; systemic
4.1
22.8
63
157
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.3
22.6
187
862
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
22.3
301
1663
XCK10
NOMESCO Finland
Photography of fundus of eye
2.1
21.6
205
999
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
4.3
21.6
55
129
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
18.0
20.8
32
18
DFF00
NOMESCO Finland
Pure tone audiometry
2.0
20.7
237
1238
S01EA05
ATC
brimonidine; ophthalmic
4.1
20.6
56
138
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
3.6
20.6
67
188
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
20.4
471
3038
Q17.0
ICD-10 Finland
Accessory auricle
+∞
19.8
19
*
Q17.8
ICD-10 Finland
Other specified congenital malformations of ear
+∞
19.8
19
*
S01EC03
ATC
dorzolamide; ophthalmic
6.3
19.7
33
53
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
6.3
19.3
32
51
DC1AD
NOMESCO Finland
Temporalbone CT
4.9
19.2
42
87
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
18.3
19.1
29
16
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.8
19.0
99
368
7433A
ICD-9 Finland
Congenital anomalies of eye, Congenital cataract and lens anomalies
70.3
18.7
21
*
CKD60
NOMESCO Finland
Anterior vitrectomy
7.4
18.7
27
37
S01ED51
ATC
timolol, combinations; ophthalmic
2.3
18.5
139
615
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
18.3
194
985
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
4.1
18.3
50
124
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
17.7
18.2
28
16
ZXB10
NOMESCO Finland
Medial
5.4
18.1
35
65
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
4.7
18.0
41
88
S01EX03, ,
ATC
5.1
17.9
37
73
Q10.30
ICD-10 Finland
Other congenital malformations of eyelid
+∞
17.7
17
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.8
17.4
290
1707
Z31.5
ICD-10 Finland
Genetic counselling
2.0
17.1
196
1023
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
5.9
17.0
30
51
WX402
NOMESCO Finland
General anaesthesia
1.5
16.8
602
4286
74439
ICD-8 Finland
Congenital anomalies of eye, Cataracta NUD
63.7
16.7
19
*
114
Kela drug reimbursment
Glaucoma
2.2
16.6
138
638
UJC01
NOMESCO Finland
Scopy of lower throat
5.6
16.5
31
56
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
2.5
16.0
101
413
XCD00
NOMESCO Finland
Clinical examination of eye in general anaesthesia
12.3
15.8
28
23
Q13.1
ICD-10 Finland
Absence of iris
+∞
15.6
15
*
DEE00
NOMESCO Finland
Osseous fixation of hearing aid
85.6
15.6
17
*
74482
ICD-8 Finland
Congenital anomalies of eye, Ptosis
85.6
15.6
17
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
15.4
2071
18544
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.1
15.2
142
687
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.8
15.2
224
1270
EP1CM
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with 3 Tesla magnet
20.1
15.1
22
11
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
15.1
14.9
24
16
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.5
14.6
610
4460
DBD30
NOMESCO Finland
Correction of atresia of external auditory canal
+∞
14.6
14
*
Q17.9
ICD-10 Finland
Congenital malformation of ear, unspecified
+∞
14.6
14
*
J01DA01
ATC
[U] cefalexin
1.4
14.5
1478
12576
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
2.7
14.3
74
275
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
10.5
14.2
27
26
Q13.4
ICD-10 Finland
Other congenital corneal malformations
+∞
13.5
13
*
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
13.5
281
1756
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.1
13.3
122
587
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
13.3
846
6654
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
4.7
13.3
30
64
JDB10
NOMESCO Finland
Percutaneous gastrostomy
3.9
13.2
38
98
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
13.2
546
3977
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
5.8
13.2
24
42
S01AX11
ATC
[U] ofloxacin
2.6
13.2
73
281
H26.00
ICD-10 Finland
Infantile, juvenile and presenile cataract
40.3
13.1
16
*
J01DB01
ATC
cefalexin; oral
1.4
13.0
2223
20358
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
3.4
12.9
45
133
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.7
12.8
254
1568
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
2.4
12.6
82
341
Q16.9
ICD-10 Finland
Congenital malformation of ear causing impairment of hearing, unspecified
+∞
12.5
12
*
Q14.0
ICD-10 Finland
Congenital malformation of vitreous humour
+∞
12.5
12
*
WX400
NOMESCO Finland
Inhalation anesthesy
2.0
12.5
135
691
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
9.3
12.5
25
27
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
21.4
12.0
17
8
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
4.6
11.9
28
62
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.8
11.8
169
949
TCG10
NOMESCO Finland
Removal of sutures from cornea
9.0
11.7
24
27
P85
ICPC
Mental retardation
4.9
11.7
25
51
H50.1
ICD-10 Finland
Divergent concomitant strabismus
4.0
11.7
32
80
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
65.2
11.6
13
*
Z97.4
ICD-10 Finland
Presence of external hearing-aid
2.4
11.6
78
330
ZXD20
NOMESCO Finland
Day surgery
1.6
11.5
287
1874
Q12.1
ICD-10 Finland
Congenital displaced lens
+∞
11.5
11
*
H26.2
ICD-10 Finland
Complicated cataract
3.8
11.3
34
91
H26.4
ICD-10 Finland
After-cataract
1.9
11.2
140
755
H44.5
ICD-10 Finland
Degenerated conditions of globe
25.1
11.1
15
6
D18.1
ICD-10 Finland
Lymphangioma, any site
11.2
11.0
20
18
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
11.0
207
1259
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
3.7
10.9
34
93
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
3.3
10.9
41
127
Q67.0
ICD-10 Finland
Facial asymmetry
28.1
10.7
14
5
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
10.7
678
5299
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
4.1
10.7
29
72
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
2.9
10.5
48
167
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
10.5
392
2792
Q16.4
ICD-10 Finland
Other congenital malformations of middle ear
+∞
10.4
10
*
Q10.2
ICD-10 Finland
Congenital entropion
+∞
10.4
10
*
S01EA03
ATC
apraclonidine; ophthalmic
4.2
10.3
27
65
8070/3-C09.9
ICD-O-3
Squamous cell carcinoma, NOS, of tonsil, NOS
32.6
10.3
13
*
3768
FHL
Eye examination under general anesthesia
23.4
10.2
14
6
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
4.0
10.2
28
70
K11.2
ICD-10 Finland
Sialoadenitis
2.2
10.2
84
389
DFF15
NOMESCO Finland
Speech audiometry
2.2
10.1
86
403
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.9
10.1
130
708
RL140, ,
NOMESCO Finland
5.0
10.0
21
42
S01EE01
ATC
latanoprost; ophthalmic
2.1
10.0
93
452
R51.80
ICD-10 Finland
Headache
1.4
9.8
470
3500
H50.0
ICD-10 Finland
Convergent concomitant strabismus
3.1
9.8
40
131
ZZG00
NOMESCO Finland
Graft of cartilage
10.6
9.8
18
17
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.4
9.7
470
3506
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
3.5
9.7
33
96
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
3.2
9.7
37
116
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.7
9.6
178
1079
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.6
9.6
52
199
Q87.03
ICD-10 Finland
Syndrome Goldenhar
100.4
9.4
10
*
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
7.5
9.4
21
28
DAW99
NOMESCO Finland
Other operation on auricle
17.6
9.4
14
8
S01EC04
ATC
brinzolamide; ophthalmic
2.4
9.4
62
261
7442B
ICD-9 Finland
Congenital anomalies of ear, face and neck, Other specified anomalies of ear[MICROTIA]
+∞
9.4
9
*
Q11.1
ICD-10 Finland
Other anophthalmos
+∞
9.4
9
*
74420
ICD-8 Finland
Congenital anomalies of eye, Buphthalmus (glaucoma)
+∞
9.4
9
*
DAX08
NOMESCO Finland
Fitting of hearing aid
2.1
9.2
90
445
EP1AE, ,
SPAT
2.1
9.1
80
381
QAA10
NOMESCO Finland
Incision of skin of head or neck
11.5
9.1
16
14
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
9.0
459
3455
S01EC54
ATC
brinzolamide, combinations; ophthalmic
4.1
9.0
24
59
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
1.8
9.0
137
787
Z3231
NOMESCO Finland
Registered nurse
1.3
9.0
638
5058
D18.0
ICD-10 Finland
Haemangioma, any site
2.4
8.9
62
267
WX140
NOMESCO Finland
Parabulbar anesthesy
2.2
8.9
76
357
H54.1
ICD-10 Finland
Severe visual impairment, binocular
24.1
8.9
12
5
N02BE01
ATC
paracetamol; systemic, rectal
1.3
8.9
2257
21086
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
8.0
8.8
19
24
H57.0
ICD-10 Finland
Anomalies of pupillary function
3.7
8.7
27
74
DDA00
NOMESCO Finland
Stapedotomy
4.1
8.7
23
56
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
8.7
947
7953
UGC02
NOMESCO Finland
Rigid bronchoscopy
4.6
8.6
20
44
CJD20
NOMESCO Finland
Extracapsular cataract extraction with implantation of artificial lens in posterior chamber
11.6
8.6
15
13
H27.1
ICD-10 Finland
Dislocation of lens
9.0
8.5
17
19
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
3.5
8.5
28
80
3242
FHL
Levator resection
90.3
8.4
9
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
3.9
8.4
24
62
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
8.4
773
6347
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.8
8.3
126
722
Q11.2
ICD-10 Finland
Microphthalmos
+∞
8.3
8
*
7432A
ICD-9 Finland
Congenital anomalies of eye, Buphthalmos[GLAUCOMA CONGENITUM]
+∞
8.3
8
*
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
4.0
8.3
23
58
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.0
8.3
90
463
WX002
NOMESCO Finland
Sedation and analgesia
1.4
8.3
356
2597
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
8.3
1149
9919
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
8.2
554
4352
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
8.2
912
7664
S01EB01
ATC
pilocarpine; ophthalmic
8.1
8.1
17
21
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
17.2
8.1
12
7
ZXC10
NOMESCO Finland
Use of laser
2.4
8.1
51
211
H26.01
ICD-10 Finland
Infantile, juvenile and presenile cataract
11.7
8.1
14
12
ENB99
NOMESCO Finland
Other excision of pharynx and adjacent structures
22.1
8.0
11
5
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
3.5
7.8
26
75
ZXD05
NOMESCO Finland
Urgent procedure
1.3
7.8
685
5581
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.7
7.8
133
791
J01MA02
ATC
ciprofloxacin; systemic
1.3
7.7
727
5974
4105
FHL
Earlobe reconstruction or plastic
45.1
7.7
9
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.7
7.7
123
717
J01FF01
ATC
clindamycin; systemic
1.3
7.6
557
4421
R13
ICD-10 Finland
Dysphagia
1.7
7.6
138
833
Q25.0
ICD-10 Finland
Patent ductus arteriosus
3.7
7.6
23
62
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
1.9
7.6
86
450
ENA32
NOMESCO Finland
Incision of deep pharyngeal infection
8.0
7.6
16
20
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
8.0
7.6
16
20
Z3226
NOMESCO Finland
Physiotherapist
1.4
7.5
394
2974
SPAT1153
SPAT
Removal of sutures
1.3
7.5
585
4687
H60.0
ICD-10 Finland
Abscess of external ear
3.7
7.5
23
63
QAB10
NOMESCO Finland
Major dressing of wound of skin of head or neck
3.9
7.4
21
54
7436B
ICD-9 Finland
Congenital anomalies of eyelids, lachrymal system and orbit[PTOSIS CONGENITA]
80.3
7.4
8
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
1.7
7.3
118
690
3719
FHL
Other measure in this category
+∞
7.3
7
*
Q87.27
ICD-10 Finland
CHARGE association
+∞
7.3
7
*
Q14.9
ICD-10 Finland
Congenital malformation of posterior segment of eye, unspecified
+∞
7.3
7
*
3743A
ICD-9 Finland
Other disorders of eyelids, Ptosis of eyelid[PTOSIS]
+∞
7.3
7
*
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
7.3
7
*
QAE40
NOMESCO Finland
Repair of anomaly or lesion after disease of skin of head or neck
10.9
7.3
13
12
WX704
NOMESCO Finland
Intubation
1.6
7.3
174
1127
Q87.09
ICD-10 Finland
Other congenital malformations that mainly affect the appearance of the face
15.8
7.2
11
7
D21.0
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of head, face and neck
5.8
7.2
19
33
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
3.7
7.2
22
60
ELB40
NOMESCO Finland
Partial parotidectomy
3.1
7.1
28
90
H26.02
ICD-10 Finland
Presenil cataract
2.4
7.1
48
205
EP1AT
NOMESCO Finland
Punction of soft tissue of neck with ultrasound guidance
12.0
7.1
12
10
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2.3
7.1
52
231
H03AA01
ATC
levothyroxine sodium; systemic
1.3
7.1
455
3545
C09.0
ICD-10 Finland
Malignant neoplasm: Tonsillar fossa
8.8
7.0
14
16
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.5
7.0
201
1356
WX142
NOMESCO Finland
Sub-tenon anesthesy
4.2
7.0
18
43
CG2T4
NOMESCO Finland
Topography assessment of cornea
3.3
7.0
25
76
DFF20
NOMESCO Finland
Audiometry for children
3.3
7.0
25
76
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.7
6.9
116
686
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.2
6.8
952
8176
R62.0
ICD-10 Finland
Delayed milestone
2.4
6.8
46
197
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
4.3
6.7
17
40
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
4.3
6.7
17
40
H54.0
ICD-10 Finland
Blindness, binocular
16.7
6.7
10
6
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.6
6.7
161
1044
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.7
6.7
115
685
Q21.10
ICD-10 Finland
Persistent ostium secundum
2.9
6.7
29
99
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.3
6.7
481
3805
H52.0
ICD-10 Finland
Hypermetropia
2.0
6.7
67
337
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
6.6
291
2131
H60.8
ICD-10 Finland
Other otitis externa
1.9
6.6
82
443
H50.30
ICD-10 Finland
Intermittent esotropy
3.1
6.6
27
89
H52.1
ICD-10 Finland
Myopia
1.7
6.6
118
711
F82
ICD-10 Finland
Specific developmental disorder of motor function
2.7
6.6
33
122
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
2.9
6.6
29
100
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
12.3
6.6
11
9
H52.2
ICD-10 Finland
Astigmatism
2.0
6.5
67
340
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
6.2
6.5
16
26
DEW99
NOMESCO Finland
Other operation on mastoid and temporal bone
70.0
6.4
7
*
H40.0
ICD-10 Finland
Glaucoma suspect
1.7
6.4
124
763
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
1.7
6.4
105
618
F83
ICD-10 Finland
Mixed specific developmental disorders
2.3
6.4
44
190
C01
ICD-10 Finland
Malignant neoplasm of base of tongue
14.3
6.4
10
7
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
6.4
1429
12872
K01.0
ICD-10 Finland
Embedded teeth
1.9
6.4
77
413
XKD00
NOMESCO Finland
Uroflowmetry
1.5
6.4
210
1459
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
11.0
6.3
11
10
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
6.3
208
1446
R06.4
ICD-10 Finland
Hyperventilation
2.4
6.3
40
167
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
1.8
6.3
93
532
RK320, ,
NOMESCO Finland
3.8
6.3
18
47
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
1.8
6.3
86
481
Q16.2
ICD-10 Finland
Absence of eustachian tube
+∞
6.3
6
*
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
6.3
6
*
3690A
ICD-9 Finland
Blindness and low vision, Profound impairment, both eyes
+∞
6.3
6
*
Q15.8
ICD-10 Finland
Other specified congenital malformations of eye
+∞
6.3
6
*
37400
ICD-8 Finland
Cataract, Infantilis, juvenilis
+∞
6.3
6
*
Q10.1
ICD-10 Finland
Congenital ectropion
+∞
6.3
6
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
6.3
6
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
2.2
6.2
48
218
A02BC02
ATC
pantoprazole; systemic
1.2
6.2
1462
13226
H60.9
ICD-10 Finland
Otitis externa, unspecified
1.5
6.1
212
1486
A02BA02
ATC
ranitidine; systemic
1.4
6.1
290
2154
S18
ICPC
Laceration/cut
1.2
6.1
1022
8929
Q53.2
ICD-10 Finland
Undescended testicle, bilateral
8.6
6.0
12
14
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.3
6.0
522
4231

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
159
483
3.43
43.13
1.3
1.2
—
—
—
0
0
1136
9383
1.35
13.05
5.7
5.4
36.97
36.72
g/l
0.72
1063
8842
1556
13473
1.34
13.00
6.1
5.3
6.47
6.40
mmol/l
0.49
1452
12520
1162
9654
1.34
12.75
8.7
7.4
1.21
1.21
mmol/l
0.01
1091
9006
1281
10800
1.34
12.72
8.9
7.6
1.21
1.21
mmol/l
0.10
1120
9439
1075
8860
1.34
12.32
2.0
2.0
—
—
—
0
0
2584
24455
1.62
12.15
15.4
13.3
22.37
21.98
mg/l
0.22
2119
19582
1637
14367
1.33
12.02
9.3
9.8
4.11
3.98
e9/l
1.42
1447
12469
2504
23549
1.53
11.89
16.7
14.5
139.58
139.59
mmol/l
0.09
2465
23043
42
126
3.37
11.77
9.7
7.3
5.72
146.62
ug/l
0.56
32
84
2502
23597
1.50
10.97
17.0
14.6
3.93
3.93
mmol/l
0.08
2461
23026
2142
19676
1.36
10.84
4.9
4.3
14.68
14.52
pmol/l
2.40
1975
18277
1525
13404
1.30
10.33
7.1
7.1
2.02
2.03
e9/l
0.12
1372
11906
1405
12233
1.29
10.16
7.1
7.0
55.60
55.57
%
0.03
1355
11782
398
2867
1.45
10.02
1.3
1.2
—
—
—
0
0
1525
13456
1.29
9.79
7.3
7.4
0.20
0.19
e9/l
1.31
1364
11837
1372
11955
1.28
9.68
7.3
7.3
0.67
0.67
%
0.15
1301
11299
1373
11974
1.28
9.58
7.3
7.2
2.90
2.83
%
0.55
1302
11318
1374
11993
1.28
9.49
7.3
7.3
8.50
8.52
%
0.11
1299
11353
405
2958
1.43
9.44
1.8
1.7
—
—
—
0
0
2399
22582
1.40
9.34
6.0
5.2
1.88
1.82
mu/l
0.47
2271
21399
1476
13025
1.28
9.23
7.1
7.1
0.57
0.56
e9/l
1.14
1310
11278
1477
13039
1.28
9.19
7.1
7.1
0.04
0.04
e9/l
0.09
1312
11293
1887
17181
1.29
9.14
8.0
7.6
79.39
79.63
u/l
0.07
1801
16368
2642
25364
1.58
8.99
17.7
15.5
72.90
71.63
umol/l
1.06
2623
25063
1412
12462
1.26
8.54
7.2
7.1
29.90
29.93
%
0.04
1358
11923
1044
8887
1.28
8.54
10.1
10.9
1.16
1.17
inr
0.25
884
7377
57
250
2.31
7.93
7.7
4.7
171.56
80.84
u/ml
0.57
21
78
676
5527
1.29
7.42
4.6
4.2
—
—
—
0
0
1735
15825
1.25
7.34
4.8
4.3
1206.79
1237.40
e6/l
0.01
24
201
18
42
4.31
7.21
1.2
1.3
2.00
1.09
iu/ml
—
10
19
246
1730
1.46
6.99
4.0
3.5
4.65
4.65
pmol/l
0.05
220
1556
1292
11471
1.23
6.81
6.2
6.3
12.40
11.88
umol/l
0.35
1216
10880
1241
10980
1.23
6.73
2.8
2.6
73.91
73.09
nmol/l
0.48
1159
10246
2767
27055
1.82
6.51
23.1
20.1
261.42
258.87
e9/l
1.33
2730
26533
1810
16687
1.23
6.49
4.9
4.3
1.40
3.06
—
5
19
2619
25296
1.44
6.47
11.2
10.5
26.26
26.13
u/l
0.10
2566
24680
737
6184
1.26
6.42
4.9
4.0
7.39
7.39
ph
0.19
521
4339
2767
27063
1.81
6.39
23.0
20.0
89.84
89.76
fl
0.36
2753
26835
2767
27067
1.81
6.32
23.0
20.0
30.02
30.00
pg
0.25
2753
26840
2767
27068
1.81
6.31
23.7
20.6
42.25
40.99
%
0.34
2753
26830
2767
27069
1.80
6.29
23.0
20.1
4.56
4.56
e12/l
0.01
2728
26490
1271
11330
1.22
6.25
3.0
2.9
—
—
estimate
—
0
0
737
6203
1.25
6.23
2.3
2.3
358.33
218.22
u/l
0.64
705
5932
2767
27076
1.79
6.19
23.3
20.3
136.04
135.88
g/l
0.25
2753
26849
378
2920
1.34
6.18
1.5
1.5
—
—
—
0
0
2767
27079
1.79
6.14
23.1
20.1
6.84
6.76
e9/l
1.22
2727
26486
403
3164
1.32
5.88
2.1
2.0
—
—
—
0
0
859
7405
1.23
5.75
3.4
3.2
2.36
2.36
mmol/l
0.00
782
6835
175
1200
1.49
5.69
7.5
6.9
24.62
24.39
mmol/l
0.57
167
1159
2227
21105
1.25
5.69
3.8
3.7
1.26
1.24
mmol/l
0.65
2099
19884
952
8313
1.22
5.58
3.1
3.4
29.76
30.97
u/l
0.55
902
7911
855
7386
1.23
5.58
5.3
6.5
—
—
—
0
0
220
1583
1.42
5.56
5.7
4.8
86.68
77.45
ng/l
0.82
200
1439
242
1776
1.40
5.47
6.8
6.2
7.41
7.41
ph
0.80
212
1489
246
1811
1.39
5.46
6.8
6.1
5.23
5.10
kpa
1.72
238
1746
578
4798
1.26
5.42
3.8
3.4
1269.86
1050.82
ng/l
0.32
485
3990
324
2503
1.33
5.29
1.4
1.4
—
—
—
0
0
843
7334
1.21
5.03
3.7
3.2
43.85
52.71
ng/l
0.24
479
4227
317
2463
1.32
4.98
6.1
5.9
5.90
5.83
kpa
0.74
309
2400
434
3516
1.28
4.97
3.2
2.6
2.41
2.41
g/l
0.06
405
3267
687
5862
1.23
4.97
2.7
2.4
—
—
—
0
0
187
1335
1.43
4.96
7.2
6.7
—
—
—
0
0
2260
21542
1.24
4.96
4.5
4.1
5.73
5.71
mmol/l
0.25
2104
20134
763
6584
1.22
4.93
1.5
1.5
2.06
2.13
g/l
0.52
490
4171
2268
21653
1.23
4.75
18.2
16.3
13.37
13.35
%
0.33
2238
21384
814
7093
1.21
4.73
2.9
2.7
59.24
69.63
u/l
0.43
765
6612
464
3812
1.26
4.72
3.2
2.6
13.39
14.09
umol/l
1.32
438
3569
315
2469
1.31
4.65
6.0
5.9
7.37
7.37
ph
0.79
197
1492
396
3203
1.27
4.59
3.3
2.7
22.16
23.47
%
1.20
372
2994
306
2396
1.31
4.55
6.1
6.0
1.50
1.55
mmol/l
0.09
267
2023
15
36
4.18
4.51
1.3
1.3
0.79
0.22
iu/ml
—
9
20
1028
9185
1.19
4.48
2.1
1.9
97.83
96.77
pmol/l
0.33
562
5085
879
7748
1.19
4.46
2.6
2.4
—
—
—
0
0
855
7532
1.19
4.35
1.5
1.5
1.45
1.73
u/ml
0.33
228
2034
501
4197
1.23
4.27
2.7
2.8
142.36
109.30
ug/g
0.79
422
3366
372
3014
1.27
4.25
1.2
1.2
—
—
—
0
0
435
3595
1.25
4.19
5.2
5.0
0.82
0.82
mmol/l
0.35
415
3428
2348
22576
1.23
4.15
4.5
4.3
4.61
4.63
mmol/l
0.47
2237
21499
2363
22739
1.23
4.12
5.0
4.7
2.75
2.75
mmol/l
0.00
2243
21559
275
2152
1.31
4.12
5.2
5.7
4.84
4.76
kpa
0.26
266
2095
734
6412
1.19
4.06
2.5
2.4
2.69
2.65
mg/l
0.19
649
5605
379
3095
1.26
4.05
9.7
7.4
1.13
1.10
mmol/l
0.89
359
2901
764
6704
1.19
4.01
3.1
2.7
—
—
—
0
0
259
2019
1.31
4.00
10.9
9.6
7.62
7.76
mmol/l
0.15
253
1958
274
2155
1.30
3.96
2.3
2.2
11.92
12.03
nmol/l
0.07
254
1972
1486
13771
1.17
3.96
3.6
3.3
85.98
89.18
ug/l
0.35
1412
13075
613
5297
1.20
3.80
2.8
2.7
335.33
328.26
umol/l
0.95
566
4780
244
1904
1.31
3.75
13.1
11.8
25.04
24.69
mmol/l
1.08
244
1896
1256
11529
1.16
3.71
11.4
10.9
0.00
0.00
e9/l
0.24
1026
9376
170
1266
1.36
3.60
3.2
3.6
149.90
175.66
ng/l
0.46
153
1132
2330
22461
1.21
3.60
4.5
4.2
1.43
1.45
mmol/l
1.65
2212
21281
231
1804
1.31
3.54
5.1
3.7
7.36
7.35
ph
0.37
164
1321
104
716
1.47
3.44
2.3
2.5
366.69
369.92
ug/l
0.01
98
672
113
794
1.44
3.37
1.9
2.1
3.33
3.82
iu/l
0.44
45
349
824
7368
1.17
3.36
3.7
3.7
7.92
8.21
mmol/l
0.90
704
6510
671
5906
1.18
3.33
4.7
4.7
91.82
91.75
%
0.03
663
5788
25
116
2.17
3.22
1.1
1.1
10.79
9.02
u/ml
—
5
23
267
2152
1.27
3.22
10.6
9.3
7.41
7.41
ph
0.02
146
1153
145
1076
1.37
3.17
14.5
12.3
16.34
16.08
%
0.56
137
1035
537
4657
1.19
3.16
1.4
1.3
22.67
25.74
iu/ml
0.32
142
1297
268
2166
1.26
3.16
1.4
1.3
313.08
264.42
u/ml
0.15
242
2020
145
1079
1.36
3.12
2.7
3.8
21.23
21.24
s
0.00
129
968
2159
20749
1.17
3.11
5.5
5.1
37.76
37.67
mmol/mol
0.17
2045
19766
270
2189
1.26
3.10
11.9
10.3
—
—
—
0
0
10
25
4.01
3.08
2.3
3.1
103.80
99.04
g/l
—
10
25
365
3064
1.22
3.04
2.5
3.1
4.05
4.73
e9/l
1.91
326
2734
395
3345
1.21
3.02
2.9
3.2
29.29
29.61
s
0.65
388
3254
13
46
2.83
2.91
1.6
1.2
—
—
—
0
0
238
1918
1.26
2.89
11.1
9.8
96.12
95.71
%
0.50
224
1857
281
2311
1.24
2.86
4.4
4.1
31.86
32.07
%
0.12
202
1663
1155
10676
1.14
2.86
3.6
3.2
6.25
6.25
ph
0.03
618
6024
46
275
1.68
2.84
1.6
1.3
0.17
0.24
nmol/l
0.47
36
212
213
1699
1.27
2.82
1.4
1.5
—
—
—
0
0
317
2649
1.22
2.78
2.6
2.2
365.55
374.50
nmol/l
0.33
297
2479
41
240
1.72
2.74
2.7
2.2
0.90
0.88
%
0.08
29
150
445
3845
1.19
2.73
4.0
3.5
848.82
453.96
ng/l
0.43
282
2495
259
2127
1.24
2.68
10.7
9.3
0.99
0.75
mmol/l
0.48
206
1727
128
961
1.35
2.65
9.8
10.2
1.37
1.26
mg/l
0.93
120
911
649
5794
1.16
2.64
4.8
4.3
12.10
12.43
mg/mmol
0.03
430
3774
458
3981
1.18
2.62
3.0
2.9
0.97
1.16
e6/l
0.48
253
1991
1407
13215
1.13
2.62
4.1
3.6
0.00
5.83
estimate
2.77
299
2788
610
5424
1.16
2.62
2.0
2.1
1.13
1.06
mg/l
0.20
453
4051
431
3729
1.18
2.61
3.1
3.0
3.64
2.99
e6/l
0.56
225
1738
481
4200
1.17
2.61
1.6
1.6
45107848.35
37708071.24
pmol/l
0.08
419
3612
652
5833
1.15
2.57
1.8
1.6
19.43
19.84
nmol/l
0.33
568
5110
48
300
1.61
2.53
1.3
1.3
0.43
0.39
g/l
0.28
38
219
48
300
1.61
2.53
1.3
1.3
—
—
—
0
0
48
300
1.61
2.53
1.3
1.3
6.73
6.41
g/l
0.25
38
223
48
300
1.61
2.53
1.3
1.3
3.02
2.84
g/l
0.28
38
222
10
31
3.23
2.51
1.1
1.5
—
—
—
0
0
975
8974
1.13
2.50
4.4
4.0
84.83
79.95
e6/l
0.08
676
5970
193
1546
1.27
2.50
1.2
1.2
—
—
—
0
0
1410
13269
1.12
2.50
4.1
3.6
0.00
0.12
estimate
0.54
289
2677
246
2026
1.23
2.50
4.8
4.6
0.45
0.62
%
1.18
75
556
350
2985
1.20
2.50
1.8
1.7
1068.70
1181.94
nmol/l
1.59
268
2311
487
4276
1.17
2.46
1.3
1.3
9.25
9.71
u/ml
0.05
194
1722
247
2039
1.23
2.46
5.2
4.9
0.06
0.11
%
0.93
70
514
721
6516
1.14
2.45
3.6
3.2
0.55
0.34
e6/l
0.93
534
4674
12
45
2.67
2.45
1.0
1.2
—
—
—
0
0
48
303
1.59
2.44
2.1
3.1
1138.50
1366.63
e6/l
1.19
34
249
1390
13083
1.12
2.43
4.1
3.6
0.00
0.00
estimate
0.80
298
2785
777
7060
1.14
2.43
4.2
3.7
0.00
0.00
estimate
1.94
284
2637
31
174
1.79
2.42
1.8
3.3
0.34
0.29
e9/l
0.21
14
100
27
145
1.87
2.41
2.2
3.4
31.55
39.21
mg/l
0.19
21
109
46
289
1.60
2.39
4.8
7.6
10.54
10.75
mg/l
0.11
41
270
565
5028
1.15
2.39
3.2
2.7
10.42
7.05
e6/l
0.53
502
4568
636
5710
1.15
2.38
4.1
3.6
66.11
59.14
mg/l
0.23
435
3798
286
2407
1.21
2.36
4.5
3.7
1.74
1.70
%
0.23
261
2195
133
1025
1.31
2.34
1.7
1.6
5.41
10.74
u/ml
2.10
31
270
138
1069
1.31
2.34
4.6
4.6
0.63
0.61
%
0.22
138
1064
814
7435
1.13
2.34
3.8
3.4
44.45
60.80
e6/l
0.51
626
5553
140
1087
1.30
2.33
4.8
4.6
1.32
1.27
%
0.18
140
1080
278
2338
1.21
2.31
1.2
1.2
133.19
147.88
u/ml
0.28
117
856
323
2758
1.19
2.29
3.2
3.4
7.41
7.20
umol/l
0.04
277
2370
258
2158
1.21
2.27
10.7
9.2
5.17
5.10
kpa
0.70
246
2081
161
1278
1.28
2.27
5.2
4.7
129.97
131.42
g/l
0.35
156
1246
258
2159
1.21
2.26
10.7
9.2
13.00
12.89
kpa
0.11
247
2083
239
1985
1.22
2.26
10.9
9.2
1.41
1.34
mmol/l
0.41
234
1942
44
278
1.59
2.25
1.5
1.3
—
—
nmol/l
—
0
0
79
565
1.41
2.24
7.6
7.1
1.19
1.25
mmol/l
0.40
69
488
217
1788
1.23
2.22
10.9
10.0
122.17
122.79
g/l
0.18
209
1749
41
256
1.61
2.21
2.0
3.2
214.73
200.39
e6/l
0.15
26
202
280
2373
1.20
2.16
2.3
2.4
9579.92
7140.44
u/l
0.51
119
915
247
2070
1.21
2.15
5.3
5.1
0.00
0.11
%
3.69
63
477
513
4571
1.15
2.13
5.1
4.8
2.04
2.10
ug/l
0.14
461
4153
139
1094
1.28
2.12
7.0
7.4
25.07
24.23
mmol/l
1.82
129
1046
257
2171
1.20
2.07
2.6
2.8
0.22
0.22
g/l
0.45
250
2046
1815
17427
1.11
2.06
3.4
3.3
40.21
39.06
u/l
0.24
1720
16689
53
358
1.49
2.05
9.6
9.3
10.87
11.52
mmol/l
0.64
45
322
53
359
1.49
2.02
1.9
1.7
63.29
69.23
mmol/l
0.47
41
304
53
359
1.49
2.02
9.6
9.3
104.73
105.30
mmol/l
0.39
45
323
56
384
1.47
2.01
1.7
1.7
—
—
—
0
0
56
384
1.47
2.01
1.7
1.7
—
—
—
0
0
56
384
1.47
2.01
1.7
1.7
—
—
—
0
0
56
384
1.47
2.01
1.7
1.7
—
—
—
0
0
70
503
1.40
1.97
6.9
3.7
—
—
—
0
0
250
2118
1.20
1.96
5.3
4.8
0.78
0.91
%
0.31
74
590
5
11
4.55
1.94
5.0
3.2
—
—
—
0
0
226
1900
1.21
1.93
1.6
1.5
18.69
19.28
iu/l
0.11
177
1536
39
251
1.56
1.89
2.0
3.2
373.87
540.27
e6/l
1.82
23
192
1072
10049
1.11
1.88
2.6
2.6
—
—
—
0
0
1060
9940
1.11
1.84
4.0
3.4
0.02
0.03
estimate
0.34
249
2334
38
246
1.55
1.81
1.6
4.2
—
—
—
0
0
62
444
1.41
1.80
8.0
4.0
2.03
2.28
mmol/l
0.27
42
273
62
444
1.41
1.80
8.0
4.0
9.02
9.06
kpa
0.08
62
438
194
1619
1.21
1.80
3.0
2.5
0.36
0.35
e6/l
0.00
185
1538
62
445
1.40
1.78
8.0
4.0
5.05
4.95
kpa
0.60
62
439
209
1759
1.20
1.78
4.8
3.4
78.01
70.52
e9/l
1.45
158
1247
70
514
1.37
1.77
3.3
3.2
33.48
33.63
umol/l
0.02
65
478
28
170
1.65
1.73
1.3
1.3
187.41
224.47
pmol/l
0.28
28
170
253
2172
1.18
1.73
3.0
3.1
10.28
10.33
g/l
0.05
238
2036
385
3414
1.15
1.73
1.8
1.8
3.43
3.44
ratio
0.05
270
2498
93
720
1.30
1.66
7.0
6.4
0.88
0.89
%
0.10
86
676
101
791
1.29
1.66
6.6
6.0
1.57
1.58
%
0.04
93
745
21
119
1.77
1.66
2.1
2.0
—
—
—
0
0
425
3806
1.14
1.66
2.7
2.6
2.43
2.43
mmol/l
0.26
373
3407
28
173
1.62
1.64
1.2
1.1
—
—
—
0
0
12
56
2.15
1.61
1.2
1.3
5.28
7.27
pmol/l
—
7
20
64
474
1.36
1.56
1.3
1.1
—
—
—
0
0
25
152
1.65
1.56
2.0
3.1
958.96
1026.51
u/ml
0.07
25
152
143
1177
1.23
1.56
1.8
1.7
—
—
—
0
0
162
1351
1.21
1.55
1.8
1.6
8.85
8.39
u/l
0.16
126
1040
23
137
1.68
1.55
2.3
4.5
198.71
159.88
umol/l
0.19
14
76
8
33
2.43
1.53
2.1
3.2
—
—
—
0
0
302
2658
1.15
1.53
1.2
1.2
—
—
—
0
0
5
15
3.34
1.52
1.0
1.1
—
—
—
0
0
116
936
1.25
1.52
1.2
1.2
—
—
—
0
0
647
5973
1.11
1.50
4.1
3.5
1.02
1.54
kg/l
0.81
420
3873
153
1275
1.21
1.49
13.5
11.4
94.39
94.12
%
0.24
153
1269
204
1749
1.18
1.46
1.6
1.7
350.00
303.63
mu/l
0.97
185
1569
802
7501
1.10
1.42
3.4
2.9
0.00
0.05
estimate
1.01
241
2288
12
60
2.00
1.38
2.3
6.4
5.10
5.14
kpa
0.05
12
60
43
306
1.41
1.36
1.5
1.5
7.39
7.70
mmol/l
0.27
43
301
197
1696
1.17
1.35
1.2
1.2
—
—
—
0
0
259
2278
1.15
1.35
2.2
2.5
33.27
59.55
u/l
0.65
228
1906
125
1033
1.22
1.34
1.9
2.9
—
—
—
0
0
192
1652
1.17
1.33
1.2
1.3
49.38
44.83
au/ml
0.12
12
95
892
8405
1.09
1.33
2.4
2.2
—
—
—
0
0
0
40
0.00
1.32
0.0
1.2
—
8.88
—
0
6
0
41
0.00
1.31
0.0
1.0
—
—
—
0
0
43
309
1.40
1.30
1.5
1.4
285.81
412.56
pmol/l
1.46
38
259
163
1389
1.18
1.28
2.1
2.3
7.03
7.49
ug/l
0.10
135
1247
477
4372
1.11
1.28
3.4
2.9
535.62
542.10
mosm/kgh2o
0.24
416
3859
29
194
1.50
1.26
1.7
2.3
-0.21
0.65
mmol/l
0.77
29
180
32
219
1.47
1.25
1.3
1.1
—
—
—
0
0
35
245
1.43
1.23
1.4
1.4
1.14
1.17
promille
0.04
27
195
30
204
1.48
1.22
1.4
1.2
116.87
113.35
pmol/l
0.15
30
204
85
683
1.25
1.21
6.8
3.7
7.41
7.41
ph
0.08
85
677
100
1214
0.82
1.20
1.5
1.5
1.30
1.26
mm
0.44
72
888
295
2642
1.13
1.19
1.6
1.6
3.36
3.40
mmol/l
0.22
187
1742
461
4234
1.11
1.19
1.9
1.7
—
—
—
0
0
8
38
2.11
1.18
3.5
2.9
8.00
5.73
ug/l
—
8
38
194
1690
1.16
1.18
2.4
1.9
1.30
1.30
g/l
0.00
185
1590
111
921
1.21
1.18
2.1
2.3
—
—
—
0
0
67
525
1.28
1.17
2.2
2.4
130.19
132.04
g/l
0.27
53
430
70
552
1.27
1.17
2.9
2.5
—
—
—
0
0
103
1241
0.82
1.16
1.5
1.5
—
—
—
0
0
30
207
1.45
1.15
3.1
2.3
23.36
28.55
mg/l
0.31
14
139
40
292
1.37
1.13
1.3
1.2
—
—
—
0
0
133
1128
1.19
1.13
2.0
2.0
0.00
0.64
estimate
0.51
30
396
103
853
1.22
1.12
1.6
1.9
0.23
0.23
g/l
0.07
95
810
5
21
2.38
1.09
1.0
1.0
—
—
—
0
0
18
112
1.61
1.08
1.4
1.2
—
—
—
0
0
182
1590
1.15
1.08
5.1
3.6
1.22
1.23
mmol/l
1.02
161
1361
27
185
1.46
1.08
1.0
1.0
—
—
—
0
0
14
82
1.71
1.05
2.2
2.3
27.07
29.83
%
0.39
14
82
71
571
1.25
1.03
1.2
1.2
—
—
—
0
0
9
46
1.96
1.03
2.0
1.1
—
—
—
0
0
7
34
2.06
1.02
1.0
1.1
—
—
—
0
0
7
34
2.06
1.02
1.0
2.1
—
—
—
0
0
31
221
1.41
1.02
1.8
1.7
58.65
55.25
%
0.17
20
146
107
1263
0.84
1.00
1.6
1.6
—
—
—
0
0
63
503
1.26
0.99
1.2
1.1
45.79
1127.64
iu/ml
0.58
22
128
15
92
1.63
0.97
1.8
1.6
0.20
0.03
estimate
0.37
15
92
20
132
1.52
0.97
2.6
2.3
1.92
2.34
u/field
0.20
12
79
35
258
1.36
0.96
1.5
1.5
0.51
0.51
e9/l
0.08
35
258
101
851
1.19
0.96
1.1
1.1
2.02
5.96
eliau/ml
—
5
127
104
881
1.19
0.93
1.6
1.9
1.14
1.18
g/l
0.79
97
837
31
226
1.38
0.92
1.7
2.2
—
—
—
0
0
666
6293
1.08
0.92
5.0
4.7
—
—
—
0
0
17
110
1.55
0.90
5.7
4.2
—
—
—
0
0
103
876
1.18
0.89
4.3
4.4
306.28
348.32
mg/l
0.22
57
461
30
219
1.37
0.89
2.8
3.3
—
—
—
0
0
199
1780
1.13
0.87
2.3
2.4
22.29
19.69
au/ml
0.22
17
213
33
247
1.34
0.85
1.3
1.2
—
—
—
0
0
23
162
1.42
0.84
1.6
1.6
23.79
34.54
%
0.90
14
104
123
1070
1.16
0.82
1.3
1.2
0.24
1.04
u/ml
—
10
79
59
481
1.23
0.81
1.3
1.6
0.83
0.71
g/l
0.30
46
384
87
738
1.18
0.80
2.5
2.8
5.43
6.35
umol/l
0.51
63
569
85
720
1.19
0.80
1.9
2.0
1.86
1.82
ug/l
0.02
72
640
0
24
0.00
0.79
0.0
1.6
—
11.33
—
0
12
126
1103
1.15
0.79
1.6
2.0
3.80
7.72
iu/ml
1.79
27
264
49
393
1.25
0.78
1.4
1.5
7.37
6.83
mmol/l
0.63
41
356
23
165
1.40
0.77
1.3
1.3
96.13
75.75
umol/l
0.38
23
165
17
115
1.48
0.76
1.0
1.1
—
—
—
0
0
6
34
1.77
0.76
1.2
1.2
—
226.40
—
0
5
6
34
1.77
0.76
5.8
5.6
0.17
0.19
%
—
6
34
6
34
1.77
0.76
2.5
1.7
—
—
—
0
0
19
132
1.44
0.75
1.7
1.8
0.82
1.32
nmol/l
1.96
12
104
404
3778
1.08
0.75
1.4
1.4
395.61
492.13
titre
0.68
82
755
2234
22018
1.07
0.75
18.1
16.6
333.54
333.40
g/l
0.31
2226
21877
5
24
2.08
0.74
1.8
1.3
38.06
29.13
nmol/l
—
5
24
179
1611
1.12
0.74
3.0
4.3
12.63
18.51
ug/l
0.35
134
1265
28
368
0.76
0.73
1.5
2.9
—
—
—
0
0
296
2738
1.09
0.72
3.1
3.0
0.72
0.73
ug/l
0.03
174
1582
10
159
0.63
0.72
3.4
2.1
—
—
—
0
0
51
417
1.23
0.70
1.7
1.7
7.89
7.49
mmol/l
0.75
46
400
18
252
0.71
0.70
1.6
1.5
—
—
—
0
0
124
1096
1.14
0.70
1.1
1.2
0.70
2.75
u/ml
4.68
76
637
7
41
1.71
0.70
4.4
2.8
—
—
—
0
0
54
445
1.22
0.69
3.6
3.8
91.11
90.97
%
0.08
54
430
156
1400
1.12
0.69
1.7
1.7
0.25
0.28
mg/l
0.24
77
648
72
611
1.18
0.69
2.0
2.2
11.09
10.97
mg/l
0.05
64
579
28
214
1.31
0.66
1.6
1.8
21.21
22.84
umol/l
0.11
28
197
133
1488
0.89
0.66
1.5
1.5
—
—
—
0
0
5
95
0.53
0.66
1.0
1.2
37.71
7.50
u/ml
—
5
81
32
250
1.28
0.65
3.1
3.8
—
—
—
0
0
18
128
1.41
0.65
2.2
2.0
113.40
100.52
umol/l
—
5
25
779
7488
1.06
0.64
3.1
2.7
0.00
0.02
0.50
12
101
20
146
1.37
0.63
1.1
1.0
11.87
17.61
u/ml
0.47
14
97
99
870
1.14
0.62
1.2
1.2
—
—
—
0
0
15
104
1.44
0.62
1.3
1.3
—
—
—
0
0
13
88
1.48
0.60
1.2
1.2
—
—
—
0
0
113
1005
1.13
0.60
1.1
1.1
6.16
6.15
u/ml
0.00
70
612
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
111
987
1.13
0.59
1.7
1.8
—
—
—
0
0
134
1206
1.12
0.59
1.3
1.4
—
—
—
0
0
107
950
1.13
0.59
1.1
1.1
3.87
2.33
u/ml
0.48
67
554
22
166
1.33
0.58
1.3
1.2
5.91
8.21
mm/h
2.16
22
166
8
54
1.48
0.57
1.4
1.3
—
—
—
0
0
47
392
1.20
0.57
4.7
3.8
—
—
—
0
0
6
36
1.67
0.56
1.2
1.1
—
—
—
0
0
246
2289
1.08
0.55
1.7
2.2
—
—
—
0
0
163
1489
1.10
0.55
3.0
2.8
67.77
66.95
g/l
0.64
149
1396
212
1963
1.09
0.54
1.6
2.2
—
—
—
0
0
44
367
1.20
0.54
2.2
1.4
—
7.91
u/ml
—
0
9
64
739
0.86
0.54
1.2
1.4
—
1287.00
—
0
20
6
39
1.54
0.53
1.0
1.0
44.77
14.55
u/ml
—
6
31
6
40
1.50
0.51
1.3
1.3
61.17
65.30
ug/l
—
6
40
6
40
1.50
0.51
4.0
7.3
86.13
28.91
ug/min
—
6
26
30
242
1.24
0.51
1.1
1.0
—
—
—
0
0
588
5650
1.05
0.50
2.0
1.9
—
—
—
0
0
75
661
1.14
0.49
1.4
1.4
257.31
307.16
ug/g
0.89
35
360
7
107
0.65
0.48
1.0
1.1
9.84
40.43
iu/ml
—
7
107
65
568
1.15
0.48
3.7
2.2
10.02
10.40
g/l
0.24
55
517
172
1592
1.09
0.46
1.5
1.6
—
—
—
0
0
107
968
1.11
0.46
1.1
1.1
1.55
1.18
u/ml
0.33
57
501
55
632
0.87
0.46
1.3
1.2
10.46
43.47
u/ml
—
10
57
14
187
0.75
0.45
1.5
1.7
—
—
—
0
0
19
147
1.29
0.45
1.2
1.4
22974.44
75095.17
e6/l
—
9
80
38
320
1.19
0.44
1.6
1.7
—
—
—
0
0
79
883
0.89
0.44
1.8
1.5
194.08
219.02
u/ml
0.49
51
507
957
9326
1.04
0.44
1.8
1.9
1.39
1.35
mmol/l
0.78
830
8186
34
284
1.20
0.43
2.3
1.7
287.81
284.50
mosm/kgh2o
0.33
26
216
67
593
1.13
0.43
2.3
3.2
2.12
3.15
index
0.59
34
341
72
641
1.13
0.42
1.3
2.3
—
—
—
0
0
6
91
0.66
0.42
1.2
1.1
—
—
—
0
0
693
6715
1.04
0.42
1.9
1.8
—
—
—
0
0
26
212
1.23
0.42
1.2
1.2
—
—
—
0
0
20
158
1.27
0.41
2.5
2.8
35.68
43.66
%
1.28
12
80
11
150
0.73
0.41
2.5
3.5
—
—
—
0
0
36
306
1.18
0.39
1.4
1.6
—
—
—
0
0
8
61
1.31
0.39
1.1
2.0
40.24
41.62
g/l
—
8
61
25
205
1.22
0.39
1.0
1.1
1667.68
1450.99
miu/ml
0.53
25
205
72
646
1.12
0.38
5.8
9.5
—
—
—
0
0
35
298
1.18
0.38
2.0
2.0
—
—
—
0
0
259
2458
1.06
0.37
1.7
2.1
—
—
—
0
0
57
506
1.13
0.36
1.3
1.4
17.83
18.93
u/l
0.11
49
432
258
2451
1.06
0.36
1.7
2.1
—
—
—
0
0
38
328
1.16
0.36
2.0
2.0
1.61
1.67
mmol/l
0.12
38
322
176
1653
1.07
0.36
2.1
2.0
—
—
—
0
0
257
2443
1.06
0.36
1.7
2.1
—
—
—
0
0
9
124
0.72
0.35
1.1
1.4
129.56
165.51
mmol/24h
—
9
124
49
433
1.13
0.34
3.0
2.7
16.75
16.84
%
0.07
49
422
6
45
1.33
0.33
1.3
2.2
—
—
—
0
0
18
221
0.81
0.33
1.1
1.1
—
—
—
0
0
68
750
0.90
0.33
1.2
1.4
50.00
89.63
titre
—
8
82
60
666
0.90
0.33
1.1
1.1
5.53
21.11
au/ml
3.48
12
159
21
173
1.22
0.32
1.2
1.4
3304.25
2205.73
e6/l
0.44
12
114
20
242
0.83
0.32
1.1
1.1
—
—
—
0
0
228
2168
1.06
0.32
1.9
2.0
0.00
0.02
estimate
1.31
49
505
13
101
1.29
0.31
1.0
1.0
907.13
739.34
ng/l
—
8
73
83
762
1.09
0.31
1.3
2.0
399.05
472.41
mg/l
2.03
78
727
7
55
1.27
0.30
1.3
1.4
41.43
57.78
%
—
7
45
57
515
1.11
0.29
1.8
1.9
—
—
—
0
0
55
496
1.11
0.29
1.1
1.1
2.53
2.44
eliau/ml
0.04
23
227
7
56
1.25
0.29
1.0
1.6
9.61
9.65
mmol/l
—
7
56
134
1260
1.07
0.28
1.1
1.1
—
—
—
0
0
127
1193
1.07
0.28
1.6
1.6
60.06
59.57
ug/l
0.04
127
1193
19
158
1.20
0.28
2.9
2.6
—
—
—
0
0
12
94
1.28
0.28
3.3
2.7
—
—
—
0
0
156
1476
1.06
0.28
1.3
1.3
200.73
226.90
miu/ml
0.41
69
727
8
65
1.23
0.27
1.0
1.1
—
—
—
0
0
8
65
1.23
0.27
1.0
1.1
—
—
—
0
0
8
65
1.23
0.27
1.0
1.1
—
—
—
0
0
26
224
1.16
0.27
3.3
3.4
0.82
0.86
nmol/l
0.20
21
180
25
215
1.16
0.26
2.7
3.6
13.35
15.16
index
0.40
17
160
8
67
1.19
0.26
1.1
1.2
—
—
—
0
0
252
2424
1.04
0.25
1.7
2.1
—
—
—
0
0
13
105
1.24
0.24
2.5
2.0
120.31
102.20
ng/l
0.23
13
105
73
676
1.08
0.24
1.3
2.2
9.24
22.29
e6/l
1.02
49
479
17
142
1.20
0.24
1.2
1.4
—
—
—
0
0
46
507
0.91
0.24
1.1
1.1
—
—
—
0
0
6
85
0.71
0.24
1.0
1.0
—
—
—
0
0
21
180
1.17
0.23
1.0
1.2
5.38
21.60
u/ml
0.51
15
125
32
284
1.13
0.23
1.1
1.1
0.64
3.11
u/ml
0.84
16
103
23
199
1.16
0.23
1.2
1.2
—
—
—
0
0
37
332
1.12
0.23
1.4
1.2
0.88
3.13
u/ml
1.57
18
158
13
106
1.23
0.23
1.2
1.1
—
—
—
0
0
13
157
0.83
0.22
1.1
1.2
—
—
—
0
0
49
448
1.10
0.22
3.7
3.4
22.53
24.07
mg/l
0.13
34
294
30
267
1.12
0.21
1.7
1.6
90.68
765.92
pmol/l
—
5
33
13
107
1.22
0.21
1.0
1.0
—
—
—
0
0
184
1766
1.04
0.21
2.0
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
0.06
—
0
10
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
5.89
—
0
5
0
11
0.00
0.21
0.0
2.0
—
345.83
—
0
6
56
517
1.08
0.21
1.2
1.2
—
—
—
0
0
77
721
1.07
0.21
1.2
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
25
282
0.89
0.20
1.2
1.2
22.44
39.04
mg/l
6.04
18
233
19
164
1.16
0.20
1.4
1.4
678.84
386.61
mu/l
0.99
19
158
0
14
0.00
0.20
0.0
1.1
—
0.08
—
0
7
6
48
1.25
0.20
1.3
1.3
55.00
32.65
%
—
6
42
16
136
1.18
0.20
1.9
1.6
0.28
2.47
u/ml
2.63
16
136
77
723
1.07
0.19
1.2
1.1
—
—
—
0
0
6
50
1.20
0.19
1.0
1.4
3.00
2.45
%
—
6
42
36
327
1.10
0.19
2.1
2.3
—
—
—
0
0
73
685
1.07
0.19
1.4
2.2
1074.49
7276.77
e6/l
0.54
53
511
50
462
1.08
0.19
1.1
1.3
3.29
4.31
u/ml
0.52
21
209
11
90
1.22
0.19
1.8
1.7
—
—
—
0
0
94
892
1.06
0.18
1.3
1.3
—
—
—
0
0
7
60
1.17
0.17
4.7
4.9
1.20
1.20
mmol/l
—
7
55
222
2151
1.03
0.17
4.6
3.6
—
—
—
0
0
54
503
1.07
0.17
5.1
3.5
45.83
45.29
mg/l
0.01
42
427
116
1213
0.95
0.17
1.1
1.1
0.59
0.64
ratio
—
8
111
157
1630
0.96
0.17
1.5
1.5
63.21
59.91
ug/l
0.42
133
1392
74
698
1.06
0.17
1.4
1.5
0.31
0.41
nmol/l
0.64
60
567
7
62
1.13
0.17
1.4
1.1
—
—
—
0
0
47
506
0.93
0.17
1.1
1.1
—
—
—
0
0
281
2736
1.03
0.17
1.6
1.5
—
—
—
0
0
54
504
1.07
0.17
5.1
3.5
53.28
55.56
mg/l
0.04
42
427
17
148
1.15
0.16
1.3
1.0
19.89
19.33
mmol/l
0.27
17
140
21
236
0.89
0.16
1.1
1.1
—
—
—
0
0
311
3034
1.03
0.16
1.3
1.3
—
—
—
0
0
186
1922
0.97
0.16
1.5
1.5
—
—
—
0
0
88
838
1.05
0.15
1.4
1.3
—
—
—
0
0
19
168
1.13
0.15
1.4
1.4
73.00
73.88
%
0.15
19
162
171
1655
1.04
0.15
1.5
1.4
—
—
—
0
0
203
1971
1.03
0.15
2.5
2.2
6.12
6.17
ph
0.34
119
1257
12
102
1.18
0.15
1.4
1.6
83.42
93.42
nmol/24h
0.20
12
102
16
140
1.14
0.15
1.0
1.0
—
—
—
0
0
11
93
1.18
0.14
1.0
1.3
—
—
—
0
0
37
343
1.08
0.14
2.2
1.2
16.42
36.00
u/l
1.38
32
293
46
431
1.07
0.14
2.6
2.6
—
41.65
—
0
30
12
103
1.17
0.13
1.7
2.5
8.46
8.23
mmol/l
0.07
12
103
12
103
1.17
0.13
1.8
1.6
1440.00
2936.47
titre
—
6
17
8
98
0.82
0.13
3.1
2.6
17.11
16.59
%
—
8
98
116
1118
1.04
0.13
3.1
2.4
—
—
—
0
0
105
1011
1.04
0.13
3.5
3.0
1.02
1.02
ratio
0.05
92
908
17
190
0.89
0.13
1.4
1.3
—
—
—
0
0
13
148
0.88
0.12
1.2
1.6
—
—
—
0
0
78
747
1.05
0.12
1.1
1.2
—
—
—
0
0
44
414
1.06
0.12
2.3
2.6
81.51
107.03
ug/min
0.17
25
266
15
133
1.13
0.12
1.3
1.3
—
—
—
0
0
20
220
0.91
0.12
1.2
1.1
—
—
—
0
0
13
147
0.88
0.11
1.6
2.7
21.78
240.29
ug/l
0.69
13
129
871
8631
1.01
0.11
1.7
1.7
—
—
—
0
0
17
153
1.11
0.11
1.1
1.4
—
—
—
0
0
123
1267
0.97
0.11
1.1
1.1
—
—
—
0
0
61
638
0.96
0.11
2.9
3.6
2101.33
2416.84
u/ml
0.06
54
548
10
115
0.87
0.10
1.3
1.3
51.70
71.61
ug/l
—
10
115
52
495
1.05
0.10
1.1
1.1
—
—
—
0
0
72
692
1.04
0.10
1.0
1.1
0.43
0.65
u/ml
0.24
25
261
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
81
782
1.04
0.09
1.1
1.1
4.87
4.73
u/ml
0.02
44
427
5
47
1.06
0.09
1.8
1.2
—
0.36
—
0
8
17
155
1.10
0.09
2.5
1.8
2.98
3.58
mg/l
0.60
17
150
56
537
1.04
0.09
1.4
1.3
—
—
—
0
0
296
3004
0.98
0.09
1.6
1.6
956.50
984.34
mu/l
0.24
258
2599
16
175
0.91
0.08
1.5
1.3
17324.00
100489.37
e6/l
—
10
115
71
686
1.04
0.08
1.2
2.0
3.78
3.62
mmol/l
0.57
65
654
28
297
0.94
0.08
1.1
1.1
32.75
17.02
u/ml
—
6
113
22
205
1.07
0.07
1.9
2.2
0.69
3.89
u/ml
—
8
68
6
75
0.80
0.07
1.2
1.0
—
—
—
0
0
6
75
0.80
0.07
1.2
1.0
—
—
—
0
0
6
75
0.80
0.07
1.2
1.0
—
—
—
0
0
89
866
1.03
0.07
2.8
2.0
1.43
1.38
g/l
0.19
74
770
24
225
1.07
0.07
2.5
2.6
1.40
1.33
g/24h
0.03
14
140
8
77
1.04
0.07
1.0
1.9
—
—
—
0
0
47
489
0.96
0.07
1.6
1.7
19469.25
12914.60
e6/l
0.37
32
347
13
118
1.10
0.07
1.2
1.1
—
—
—
0
0
9
86
1.05
0.07
1.0
1.3
26.78
28.12
s
—
9
86
20
214
0.93
0.07
25.4
23.3
1284.00
1395.87
nmol/l
0.30
20
207
9
88
1.02
0.07
1.6
1.7
—
—
—
0
0
42
403
1.04
0.06
1.3
1.3
—
—
—
0
0
8
95
0.84
0.06
1.5
2.1
—
—
—
0
0
56
542
1.03
0.06
1.6
1.6
626.86
354.32
mu/l
0.98
51
441
24
227
1.06
0.06
1.1
1.0
—
—
—
0
0
10
110
0.91
0.05
3.6
2.8
38.00
43.17
%
—
10
110
10
110
0.91
0.05
7.2
5.6
9.00
8.28
%
—
10
110
76
743
1.02
0.05
2.0
1.6
—
—
—
0
0
31
323
0.96
0.05
1.3
1.3
0.94
13.09
u/ml
0.97
13
130
25
262
0.95
0.04
1.3
1.3
2.42
4.65
u/ml
0.61
16
148
30
312
0.96
0.04
1.1
1.1
10.40
8.97
iu/ml
—
5
72
17
160
1.06
0.04
2.6
3.9
1.12
0.74
index
0.51
17
160
12
111
1.08
0.04
3.3
2.6
—
—
—
0
0
20
209
0.96
0.03
18.9
17.3
691.60
817.66
nmol/l
0.70
20
202
21
201
1.04
0.03
1.2
1.2
—
—
—
0
0
12
127
0.94
0.01
1.1
1.4
133.83
135.76
nmol/l
0.04
12
127
45
442
1.02
0.01
5.5
3.3
1.96
3.09
ratio
0.42
16
249
18
173
1.04
0.01
1.3
1.3
1133.33
1010.00
titre
—
6
30
22
227
0.97
0.01
1.3
1.2
0.51
0.67
ratio
2.86
12
127
38
374
1.02
0.00
1.0
1.1
1.47
1.47
g/l
0.01
38
340
21
205
1.02
0.00
1.1
1.2
—
—
—
0
0
41
415
0.99
0.00
1.1
1.2
—
—
—
0
0
74
735
1.01
0.00
1.1
1.1
5.88
7.95
u/ml
0.55
38
373
71
709
1.00
0.00
2.0
1.7
124.43
133.99
au/ml
0.25
21
209
75
751
1.00
0.00
1.3
1.3
3.28
12.06
u/ml
—
9
110
22
216
1.02
0.00
1.2
1.4
1.48
1.47
nmol/l
0.01
22
196
11
114
0.96
0.00
1.5
1.3
157.09
386.46
u/l
1.23
11
100
13
125
1.04
0.00
1.0
1.1
311.08
208.41
iu/ml
0.28
13
125
75
754
0.99
0.00
1.3
1.2
3.03
2.75
u/ml
—
7
66
31
310
1.00
0.00
1.2
1.2
—
—
—
0
0
27
271
1.00
0.00
2.4
2.1
—
—
—
0
0
15
155
0.97
0.00
1.1
1.1
—
—
—
0
0
18
178
1.01
0.00
1.6
1.1
—
—
—
0
0
5
53
0.94
0.00
1.2
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
8
82
0.98
-0.00
2.3
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.0
166.20
165.22
g/l
—
5
58
6
69
0.87
-0.00
2.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
25.84
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
3000.00
—
0
8
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
1.49
—
0
8
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.02
—
0
7
7
72
0.97
-0.00
5.3
2.8
0.62
0.62
mmol/l
—
7
72
0
7
0.00
-0.00
0.0
1.6
—
2.14
—
0
7
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.0
—
6.28
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
118.60
—
0
5
0
9
0.00
-0.00
0.0
5.1
—
139.33
—
0
9
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
70
1.00
-0.00
1.9
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
-0.00
1.0
1.1
—
0.05
—
0
5

Mortality – FinRegistry

Association

Association between endpoint Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK and mortality.

Females

Parameter HR [95% CI] p-value
Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK 1.228 [1.05, 1.43] 0.01
Birth year 0.989 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 596 out of 19221 females with Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK died.

Males

Parameter HR [95% CI] p-value
Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK 1.217 [1.07, 1.39] 0.003
Birth year 0.989 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 742 out of 18380 males with Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK died.

Mortality risk

Mortality risk for people of age

years, who have Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK.

N-year risk Females Males
1 0.12% 0.234%
5 0.592% 1.33%
10 1.52% 3.435%
15 2.831% 6.677%
20 4.722% 12.141%

Relationships between endpoints

Index endpoint: Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK – Congenital malformations of eye, ear, face and neck

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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