No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
230 |
4. Check minimum number of eventsNone |
230 |
5. Include endpointsNone |
230 |
6. Filter based on genotype QC (FinnGen only) |
208 |
Control definitions (FinnGen only)
- Control exclude
- E4_NUTRIDEF
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E50-E64
- Name in latin
- Deficientia thiamini
Similar endpoints
↥List of similar endpoints to
Thiamine deficiency
based on the number of shared cases.
Similar with more cases:
- Vitamin deficiency, wide
- Vitamin deficiency
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2748 | 938 | 1792 |
| Only index persons | 2295 | 816 | 1479 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.03 | 0.05 |
| Only index persons | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 59.15 | 58.66 | 59.36 |
| Only index persons | 59.28 | 58.60 | 59.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 208 | 74 | 134 |
| Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | 59.70 | 56.87 | 61.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 216
- Matched controls
- 2160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E51.2
ICD-10 Finland
Wernicke encephalopathy
+∞
223.7
174
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
20.8
113.4
113
108
F10.25
ICD-10 Finland
Alcohol dependence continuous use
32.2
73.3
50
20
P15
ICPC
Chronic alcohol abuse
16.8
59.4
55
43
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
15.3
54.4
53
45
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.3
38.1
93
233
N05AH04
ATC
quetiapine; oral
6.3
38.1
90
219
F10.20
ICD-10 Finland
Alcohol dependence currently independent
15.4
35.6
33
25
N07BB01
ATC
disulfiram; oral
8.9
34.1
48
67
R41.0
ICD-10 Finland
Disorientation, unspecified
13.7
33.3
33
28
AA1AD
NOMESCO Finland
CT of head and brain
5.2
32.6
121
425
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
34.0
28.7
37
13
R56.8
ICD-10 Finland
Other and unspecified convulsions
9.0
28.1
38
50
F10.09
ICD-10 Finland
Alcohol intoxication UNS
11.1
27.4
31
32
A28
ICPC
Limited function/disability NOS
5.0
26.7
77
215
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
38.6
26.4
33
10
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
9.5
25.1
32
39
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
35.5
22.1
28
9
E51.9
ICD-10 Finland
Thiamine deficiency, unspecified
+∞
20.1
19
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.7
20.1
104
432
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
60.8
19.3
22
*
A06AD11
ATC
lactulose; oral
4.4
19.1
58
165
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.7
18.7
25
32
K70.1
ICD-10 Finland
Alcoholic hepatitis
57.8
18.3
21
*
N05AX08
ATC
risperidone; systemic
5.5
18.1
39
83
N03AG01
ATC
valproic acid; systemic, rectal
6.4
17.9
32
57
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.7
17.6
47
120
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
21.5
17.3
25
13
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.4
17.3
51
141
SPAT1254
SPAT
Administration of medicine
4.3
17.3
53
151
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
22.3
16.8
24
12
E87.6
ICD-10 Finland
Hypokalaemia
7.8
16.5
24
34
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
27.0
16.4
22
9
F10.03
ICD-10 Finland
Alcohol-related acute intoxication with delirium
91.9
15.8
17
*
N05BA01
ATC
diazepam; systemic, rectal
4.0
15.5
53
163
F10.24
ICD-10 Finland
Alcohol depence active use
13.9
15.3
26
21
F05.9
ICD-10 Finland
Delirium, unspecified
16.7
15.3
24
16
N06AB04
ATC
citalopram; systemic
3.5
15.2
67
244
N06AX11
ATC
mirtazapine; oral
3.1
15.0
105
504
F10.73
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol dementia
86.1
14.8
16
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
6.4
14.3
25
43
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.7
13.6
27
53
W19
ICD-10 Finland
Unspecified fall
4.3
13.5
39
105
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
11.6
13.1
24
23
N05BA04
ATC
oxazepam; oral
3.0
13.1
79
344
N05AH03
ATC
olanzapine; systemic
4.8
13.0
32
76
K70.0
ICD-10 Finland
Alcoholic fatty liver
34.4
12.8
16
5
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.7
12.7
47
151
N05AA02
ATC
levomepromazine; systemic
5.9
12.6
24
45
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
12.5
64
253
D64.9
ICD-10 Finland
Anaemia, unspecified
3.9
12.4
41
122
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
13.6
11.9
20
16
E51.8
ICD-10 Finland
Other manifestations of thiamine deficiency
+∞
11.6
11
*
C03CA01
ATC
furosemide; systemic
2.8
11.5
85
409
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
11.5
84
402
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
12.9
11.1
19
16
G62.1
ICD-10 Finland
Alcoholic polyneuropathy
45.8
11.0
13
*
K70.4
ICD-10 Finland
Alcoholic hepatic failure
45.8
11.0
13
*
P16
ICPC
Acute alcohol abuse
11.5
11.0
20
19
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
16.6
11.0
17
11
XF400
NOMESCO Finland
ECG with 12 standard connections
3.1
10.9
55
214
N99
ICPC
Neurological disease other
29.8
10.9
14
5
N07
ICPC
Convulsion/seizure
63.2
10.7
12
*
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
11.5
10.5
19
18
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.1
10.5
23
49
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
20.0
10.4
15
8
N05BA02
ATC
chlordiazepoxide; systemic
9.9
10.3
20
22
P20
ICPC
Memory disturbance
3.2
10.1
46
168
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
42.2
10.1
12
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.7
10.0
35
108
N05CD07
ATC
temazepam; oral
3.5
9.8
38
125
Z72.1
ICD-10 Finland
Alcohol use
12.2
9.7
17
15
R53
ICD-10 Finland
Malaise and fatigue
2.6
9.7
73
350
S01.0
ICD-10 Finland
Open wound of scalp
3.6
9.3
33
102
OAB43, ,
SPAT
0.2
9.3
7
383
L28
ICPC
Limited function/disability (L)
2.9
9.3
54
226
XA800
NOMESCO Finland
Neuropsychological investigation
5.2
9.0
19
39
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.2
8.8
38
134
F10.6
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Amnesic syndrome
52.2
8.7
10
*
E86
ICD-10 Finland
Volume depletion
9.6
8.7
17
19
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.5
8.7
22
53
A29
ICPC
General symptom/complaint other
2.9
8.4
44
173
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
7.3
8.3
19
28
A04
ICPC
Weakness/tiredness general
2.9
8.1
42
164
S82.6
ICD-10 Finland
Fracture of lateral malleolus
4.3
7.8
21
53
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
12.5
7.7
13
11
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
7.6
37
139
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
7.5
64
320
F10.4
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state with delirium
82.8
7.5
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.8
7.4
41
166
N06AB03
ATC
fluoxetine; oral
2.9
7.3
38
148
U04
ICPC
Incontinence urine
4.8
7.3
17
38
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.8
7.3
40
161
N05AD01
ATC
haloperidol; systemic
6.4
7.3
18
30
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
20.9
7.2
10
5
F05.8
ICD-10 Finland
Other delirium
20.9
7.2
10
5
N29
ICPC
Neurological sympt/complt other
12.6
7.2
12
10
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
7.2
42
175
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
10.6
7.1
13
13
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.8
7.1
19
35
Z02.7
ICD-10 Finland
Issue of medical certificate
3.5
7.1
25
77
D64.8
ICD-10 Finland
Other specified anaemias
14.4
7.0
11
8
SPAT1265
SPAT
Breathalyser
14.4
7.0
11
8
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.6
6.8
23
69
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.7
6.8
22
64
SPAT1229
SPAT
Assessment of need for aid
3.7
6.8
22
64
Z2446
NOMESCO Finland
Social worker
3.5
6.6
24
75
N05CF01
ATC
zopiclone; oral
2.1
6.6
83
486
X59
ICD-10 Finland
Exposure to unspecified factor
2.4
6.5
55
272
WX872
NOMESCO Finland
Intensive care
3.6
6.5
22
66
K29.2
ICD-10 Finland
Alcoholic gastritis
71.9
6.5
7
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.2
6.4
27
93
P03
ICPC
Feeling depressed
3.1
6.3
27
94
B03BA03
ATC
hydroxocobalamin; parenteral
4.0
6.2
18
48
N02AA05
ATC
oxycodone; systemic
2.4
6.2
52
256
G72.8
ICD-10 Finland
Other specified myopathies
8.1
6.2
13
17
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
6.2
69
383
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.7
6.2
36
149
N05BA06
ATC
lorazepam; systemic, sublingual
3.6
6.2
21
63
SPAT1240
SPAT
Therapeutic discussion
3.0
6.1
29
107
K92.0
ICD-10 Finland
Haematemesis
7.0
6.1
14
21
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.0
6.1
28
102
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.0
118
806
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
71
184
5.26
26.98
3.2
2.7
0.17
0.22
g/l
5.12
63
168
100
342
4.58
26.84
4.5
3.8
0.76
0.82
mmol/l
5.95
95
330
86
265
4.73
26.36
3.3
2.0
2.26
1.57
%
3.00
79
225
86
271
4.61
25.50
6.4
6.1
0.99
1.02
mmol/l
0.52
81
253
86
286
4.33
23.48
2.4
1.6
1113.05
1233.09
nmol/l
0.58
75
224
46
101
5.52
20.76
2.3
1.8
0.71
0.38
mg/l
1.68
32
50
32
52
7.05
19.53
1.1
1.3
441.63
518.79
mg/l
0.48
27
47
84
336
3.45
16.64
2.2
1.9
—
—
—
0
0
143
811
3.26
15.33
3.2
2.0
87.63
94.63
pmol/l
1.05
96
420
26
44
6.58
15.17
1.1
1.4
2.40
9.12
e6/l
0.51
15
34
145
833
3.25
15.12
8.2
5.5
31.97
35.80
g/l
7.55
138
790
26
45
6.43
14.84
1.1
1.5
391.44
200.94
e6/l
0.27
16
35
97
451
3.09
14.58
2.9
2.0
2.74
2.79
mg/l
0.08
90
395
115
602
2.95
13.76
4.8
2.3
318.24
226.41
u/l
0.63
109
577
109
560
2.91
13.41
2.4
1.7
17.30
20.88
nmol/l
1.72
97
479
115
628
2.78
12.31
4.9
2.8
59.21
72.44
u/l
0.59
109
591
51
186
3.28
11.27
4.6
3.7
-0.36
2.15
mmol/l
2.03
46
161
36
105
3.91
11.13
3.7
3.0
-0.10
1.96
mmol/l
2.33
28
77
36
109
3.76
10.54
2.0
1.6
—
—
—
0
0
154
1037
2.69
9.97
11.1
7.9
21.23
12.22
umol/l
1.50
149
1002
57
237
2.91
9.96
10.7
8.4
0.51
1.03
mmol/l
0.33
51
198
26
67
4.27
9.45
1.8
1.8
—
—
—
0
0
25
63
4.36
9.34
1.6
1.6
—
—
—
0
0
39
139
3.20
8.84
2.5
1.6
—
—
—
0
0
58
258
2.71
8.83
2.2
1.9
—
—
—
0
0
140
939
2.40
8.53
12.4
7.8
1.18
1.21
mmol/l
2.99
125
821
55
246
2.66
8.24
2.2
1.9
—
—
—
0
0
130
853
2.32
8.22
11.1
6.7
1.17
1.21
mmol/l
4.77
125
791
59
280
2.52
7.79
3.3
2.5
24.72
24.37
%
0.05
59
265
70
373
2.30
7.07
2.0
1.7
554.41
35780270.98
pmol/l
0.50
56
327
11
8
14.40
6.97
1.1
1.3
—
—
—
0
0
14
17
8.72
6.94
1.1
1.1
—
—
—
0
0
21
60
3.77
6.62
1.6
1.3
—
—
—
0
0
50
238
2.43
6.47
3.4
5.6
358.90
238.29
u/l
0.54
50
229
15
23
6.92
6.46
1.0
1.1
—
—
—
0
0
33
129
2.84
6.31
10.8
8.0
24.24
24.75
mmol/l
0.23
33
129
57
291
2.30
6.28
9.6
6.8
101.02
104.26
mmol/l
2.81
57
291
79
462
2.12
6.22
3.3
2.4
—
—
—
0
0
14
22
6.72
5.96
1.0
1.1
—
—
—
0
0
104
695
1.96
5.50
6.1
3.6
171.66
32.78
u/l
0.83
98
656
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
12
8.67
5.12
1.1
1.3
—
—
—
0
0
16
50
3.38
4.43
1.5
1.7
—
—
—
0
0
9
12
7.77
4.40
1.1
1.0
—
—
—
0
0
62
373
1.93
4.29
5.4
4.2
120.01
455.07
ng/l
1.61
54
298
175
1455
2.07
4.28
14.0
9.2
88.15
80.08
u/l
1.19
168
1382
31
585
0.45
4.18
3.6
3.0
0.67
0.74
ug/l
0.24
22
376
162
1317
1.92
4.16
9.2
3.5
138.26
53.85
u/l
2.55
156
1255
25
106
2.54
4.08
2.9
2.4
1.37
1.30
%
0.12
25
106
19
70
2.88
4.04
4.8
4.6
44.99
57.18
mg/l
0.18
14
62
19
70
2.88
4.04
4.8
4.6
64.97
139.55
mg/l
0.42
13
61
24
103
2.50
3.83
3.0
2.3
0.57
0.60
%
0.20
24
103
106
777
1.72
3.71
3.0
2.5
64.65
77.13
nmol/l
3.45
95
699
112
835
1.71
3.67
3.8
2.8
223.17
149.67
ug/l
1.27
107
779
163
1837
0.54
3.47
4.7
5.3
1.39
1.42
mmol/l
0.30
151
1707
6
205
0.27
3.43
2.8
2.2
3.78
3.51
ratio
—
6
170
168
1875
0.53
3.40
5.2
6.1
2.51
2.69
mmol/l
1.91
157
1746
115
883
1.65
3.23
3.8
2.8
—
—
estimate
—
0
0
102
761
1.64
3.20
5.5
3.8
46.15
33.42
ng/l
0.31
86
561
6
8
7.67
3.07
1.0
1.3
—
—
—
0
0
165
1841
0.56
3.04
4.8
5.4
4.35
4.58
mmol/l
2.01
153
1725
16
64
2.62
2.95
5.5
4.1
1.56
2.53
ratio
0.54
11
36
27
138
2.09
2.90
12.9
9.4
0.52
0.64
%
1.10
27
138
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
53
2.76
2.85
2.6
2.3
0.30
0.36
iu/ml
—
9
25
15
59
2.66
2.85
1.3
1.4
—
—
—
0
0
18
78
2.43
2.83
3.7
2.8
—
—
—
0
0
7
14
5.13
2.75
1.4
1.8
13.71
14.43
u/l
—
7
14
49
313
1.73
2.71
4.3
3.2
2.00
1.55
e6/l
0.24
26
161
157
1760
0.60
2.61
3.9
4.5
1.48
1.30
mmol/l
0.83
141
1630
9
26
3.57
2.51
1.3
1.5
—
—
—
0
0
9
26
3.57
2.51
1.3
1.5
—
—
—
0
0
9
26
3.57
2.51
1.3
1.5
—
—
—
0
0
26
139
1.99
2.49
13.2
9.1
1.07
1.33
%
1.18
26
139
11
38
2.99
2.45
5.2
3.0
4.68
4.93
kpa
0.52
11
38
55
769
0.62
2.44
3.5
4.5
21.94
21.79
%
0.02
25
361
51
339
1.66
2.43
4.2
3.0
1.42
0.94
e6/l
0.56
30
186
20
98
2.15
2.40
1.6
1.4
—
—
—
0
0
5
8
6.36
2.38
3.8
1.9
—
—
—
0
0
14
59
2.47
2.34
1.6
1.5
231.40
254.20
ug/g
—
5
37
12
47
2.64
2.31
1.4
1.6
—
—
—
0
0
12
48
2.59
2.22
1.4
1.6
—
—
—
0
0
5
9
5.66
2.22
1.0
1.3
—
—
—
0
0
8
24
3.42
2.20
1.3
1.5
—
—
—
0
0
8
24
3.42
2.20
1.3
1.5
—
—
—
0
0
34
208
1.75
2.18
4.9
3.2
—
—
—
0
0
8
25
3.28
2.11
1.3
1.5
—
—
—
0
0
83
638
1.49
2.07
4.4
3.9
2.29
2.35
mmol/l
1.95
75
583
15
291
0.48
2.06
1.5
1.5
—
—
—
0
0
8
27
3.04
1.95
1.0
1.7
—
—
—
0
0
5
11
4.62
1.95
1.0
3.0
—
—
—
0
0
7
22
3.25
1.89
1.1
1.3
—
—
—
0
0
71
538
1.48
1.87
5.3
3.3
0.40
0.35
e6/l
0.13
59
389
5
12
4.24
1.83
1.0
1.2
—
—
—
0
0
5
12
4.24
1.83
1.6
1.0
—
—
—
0
0
5
12
4.24
1.83
1.6
1.0
—
—
—
0
0
6
18
3.40
1.76
4.7
2.4
-1.73
0.81
mmol/l
—
6
18
12
55
2.25
1.71
2.5
1.4
—
—
—
0
0
10
40
2.57
1.69
1.3
1.6
—
—
—
0
0
33
220
1.59
1.55
3.7
5.4
12.95
57.00
ug/l
0.63
28
183
26
163
1.68
1.55
2.7
2.4
0.36
0.12
e6/l
0.96
26
158
5
15
3.39
1.53
1.4
1.3
7.00
7.60
u/l
—
5
15
13
65
2.06
1.52
1.4
1.7
—
—
—
0
0
57
432
1.43
1.48
1.3
1.3
0.78
1.08
u/ml
0.43
13
118
6
22
2.77
1.44
1.2
1.1
—
—
—
0
0
10
46
2.23
1.42
1.4
1.4
—
—
—
0
0
12
61
2.02
1.35
1.4
1.6
—
—
—
0
0
125
1093
1.34
1.31
11.3
11.2
4.27
4.05
e9/l
0.41
110
952
9
44
2.09
1.28
1.3
1.2
—
—
—
0
0
5
19
2.67
1.22
1.4
1.4
103.40
192.88
u/l
—
5
19
81
959
0.75
1.22
3.9
5.2
2.01
2.30
ug/l
0.24
69
860
45
582
0.71
1.20
3.8
3.0
0.00
0.15
estimate
0.52
15
178
8
38
2.15
1.19
1.5
2.0
—
—
—
0
0
6
26
2.34
1.19
1.2
2.1
—
—
—
0
0
168
1793
0.72
1.18
5.7
5.2
6.07
5.99
mmol/l
0.29
155
1653
0
33
0.00
1.17
0.0
1.5
—
965.89
—
0
28
124
1097
1.31
1.13
2.8
2.8
—
—
—
0
0
12
66
1.87
1.11
1.4
1.8
—
—
—
0
0
177
1653
1.39
1.07
5.8
5.1
1.85
1.97
mu/l
0.70
167
1519
148
1349
1.31
1.04
4.7
4.1
14.46
14.85
pmol/l
1.11
137
1230
31
225
1.44
1.02
4.0
5.0
32.62
31.24
%
0.24
24
143
48
377
1.35
1.01
3.6
3.2
2.46
2.46
mmol/l
0.11
43
336
5
23
2.20
0.98
1.2
2.2
—
—
—
0
0
0
29
0.00
0.98
0.0
3.3
—
—
—
0
0
67
795
0.77
0.97
4.8
3.5
0.00
0.02
estimate
0.68
15
191
9
51
1.80
0.96
1.1
1.2
—
—
—
0
0
9
152
0.57
0.92
1.1
1.8
—
—
—
0
0
9
153
0.57
0.92
1.7
1.4
—
—
—
0
0
24
331
0.69
0.92
1.0
1.3
12.83
34.82
iu/ml
—
6
115
0
26
0.00
0.79
0.0
1.3
—
5.33
—
0
12
72
827
0.81
0.76
2.2
2.0
1.39
1.37
mmol/l
0.06
63
696
149
1389
1.23
0.71
4.9
4.4
16.77
11.58
mm/h
2.92
142
1289
5
27
1.87
0.69
1.4
1.1
—
—
—
0
0
10
62
1.64
0.66
2.6
2.7
2.00
1.39
mg/l
—
10
53
14
96
1.49
0.63
3.6
4.2
16.57
762.19
u/ml
1.11
14
83
9
138
0.64
0.63
1.0
1.6
—
—
—
0
0
8
49
1.66
0.63
1.4
1.6
—
—
—
0
0
5
30
1.68
0.62
1.6
1.7
—
—
—
0
0
5
30
1.68
0.62
1.6
1.7
—
—
—
0
0
75
664
1.20
0.59
4.6
4.1
13.26
9.13
mg/mmol
0.29
56
428
0
23
0.00
0.58
0.0
1.4
—
4.57
—
0
7
6
36
1.69
0.57
1.7
1.5
—
—
—
0
0
6
36
1.69
0.57
1.7
1.5
—
—
—
0
0
6
38
1.60
0.55
1.5
1.1
20.85
25.03
u/l
—
6
33
188
1815
1.28
0.54
35.3
16.5
30.12
24.93
mg/l
1.48
175
1487
13
179
0.71
0.52
1.5
1.6
—
—
—
0
0
6
40
1.51
0.52
1.2
2.4
6.33
6.81
pmol/l
—
6
40
7
46
1.54
0.49
4.6
3.1
0.58
2.21
index
—
7
29
67
604
1.16
0.42
2.6
3.2
1780.16
1197.54
ng/l
0.43
62
513
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
4.3
—
1.06
—
0
16
0
18
0.00
0.40
0.0
1.4
—
0.96
—
0
12
0
18
0.00
0.40
0.0
1.4
—
1.39
—
0
12
0
18
0.00
0.40
0.0
1.4
—
1.15
—
0
12
6
42
1.44
0.36
1.2
1.3
—
—
—
0
0
15
120
1.27
0.31
1.1
1.3
—
22.55
—
0
10
176
1803
0.87
0.29
31.3
15.8
85.93
80.99
ml/min/173m2
2.12
170
1685
58
533
1.12
0.27
3.3
3.1
381.22
351.42
umol/l
0.92
50
472
16
133
1.22
0.25
2.0
2.5
—
13.81
—
0
8
15
125
1.21
0.23
1.1
1.2
161.26
143.26
u/ml
—
8
41
0
11
0.00
0.21
0.0
4.6
—
205.36
—
0
11
0
11
0.00
0.21
0.0
1.4
—
12.09
—
0
11
0
10
0.00
0.21
0.0
1.2
—
90.60
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
60.38
—
0
10
0
10
0.00
0.21
0.0
1.2
—
27.40
—
0
10
0
12
0.00
0.21
0.0
1.5
—
73.53
—
0
12
45
415
1.11
0.20
1.9
1.7
0.92
1.29
mg/l
0.94
38
334
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
52
1.16
0.19
2.2
1.4
—
—
—
0
0
19
214
0.88
0.16
6.6
7.9
—
—
—
0
0
98
1016
0.94
0.16
4.4
3.5
0.00
0.00
estimate
-0.00
23
215
55
579
0.93
0.14
4.8
3.6
0.00
0.01
estimate
0.50
23
203
11
95
1.17
0.12
1.2
2.3
41.65
39.09
u/l
0.17
11
83
47
447
1.07
0.11
4.6
3.8
1.02
1.02
kg/l
0.05
33
297
177
1791
0.94
0.10
7.2
6.4
38.71
39.49
mmol/mol
0.46
170
1693
6
57
1.05
0.08
1.3
1.1
—
—
—
0
0
6
57
1.05
0.08
1.3
1.1
—
—
—
0
0
6
58
1.04
0.08
1.3
1.2
—
—
—
0
0
7
83
0.84
0.07
1.4
1.3
—
—
—
0
0
101
1029
0.97
0.07
4.3
3.6
0.00
0.00
estimate
-0.00
22
217
102
1034
0.97
0.04
4.5
3.6
0.00
1.49
estimate
0.50
19
201
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
10
100
1.00
-0.00
3.9
4.2
4.41
4.60
pmol/l
—
10
91
8
83
0.96
-0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
6.98
—
0
5
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.2
—
105.60
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
30.54
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
43.07
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint E4_THIA_DEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THIA_DEF | 4.252 [3.12, 5.8] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.177 |
During the follow-up period (1.1.1998 — 31.12.2019), 230 out of 671 females with E4_THIA_DEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THIA_DEF | 4.98 [4.14, 5.99] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 604 out of 1344 males with E4_THIA_DEF died.
Mortality risk
Mortality risk for people of age
years, who have E4_THIA_DEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.316% | 0.751% |
| 5 | 2.24% | 4.701% |
| 10 | 5.913% | 11.842% |
| 15 | 11.245% | 21.364% |
| 20 | 18.957% | 33.304% |
Relationships between endpoints
↥Index endpoint: E4_THIA_DEF – Thiamine deficiency
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data