Galactorrhea

N14_GALACTORRHEA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N64.3
  • Hospital discharge: ICD-9 2531A
  • Cause of death: ICD-10 N64.3
  • Cause of death: ICD-9 2531A

2 out of 7 registries used, show all original rules.

427

4. Check minimum number of events

None

427

5. Include endpoints

None

427

6. Filter based on genotype QC (FinnGen only)

389

Control definitions (FinnGen only)

Control exclude
N14_BREAST

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
N60-N64
Name in latin
Aliae morbositates mammae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2252 2252 -
Only index persons 2207 2207 -
Unadjusted period prevalence (%)
Whole population 0.06 0.06 -
Only index persons 0.08 0.08 -
Median age at first event (years)
Whole population - 34.59 -
Only index persons - 34.51 -

-FinnGen-

Key figures

All Female Male
Number of individuals 389 389 -
Unadjusted period prevalence (%) 0.14 0.14 -
Median age at first event (years) 34.55 34.55 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
404
Matched controls
4040
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
3708.1
307.7
360
8
E22.1
ICD-10 Finland
Hyperprolactinaemia
23.8
72.8
54
26
G02CB01
ATC
bromocriptine; systemic
11.1
51.3
58
60
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
+∞
46.8
44
*
N64.5
ICD-10 Finland
Other signs and symptoms in breast
12.5
46.6
48
43
HAB00
NOMESCO Finland
Excision of lesion of mammary gland
8.7
20.7
27
33
G02CB03
ATC
cabergoline; oral
19.4
19.4
29
16
N04BC06
ATC
cabergoline; oral
26.5
18.4
25
10
N63
ICD-10 Finland
Unspecified lump in breast
3.9
18.2
59
170
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
18.0
124
562
N62
ICD-10 Finland
Hypertrophy of breast
62.6
15.9
18
*
O92.6
ICD-10 Finland
Galactorrhoea
88.6
15.7
17
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.7
15.5
54
163
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.3
15.0
228
1455
N06AB04
ATC
citalopram; systemic
2.6
14.9
115
545
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
12.8
13.3
23
19
N61
ICD-10 Finland
Inflammatory disorders of breast
5.3
13.1
27
54
X21
ICPC
Breast sympt/compl female other
5.2
12.3
26
53
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
12.2
199
1272
N64.9
ICD-10 Finland
Disorder of breast, unspecified
18.8
12.2
18
10
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.1
12.1
167
1001
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.1
12.0
54
191
R51.80
ICD-10 Finland
Headache
2.3
11.7
111
570
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.4
11.3
96
469
R42
ICD-10 Finland
Dizziness and giddiness
2.3
10.9
97
483
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.5
10.6
73
324
M54.5
ICD-10 Finland
Low back pain
2.0
10.5
190
1241
A04
ICPC
Weakness/tiredness general
2.3
10.2
89
438
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.7
10.1
57
229
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.5
10.0
36
111
N06AB10
ATC
escitalopram; oral
2.1
10.0
134
784
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.9
9.9
48
177
N03AX16
ATC
[U] pregabalin
2.2
9.9
101
531
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
9.8
48
178
P01AB01
ATC
metronidazole; oral, rectal
1.9
9.5
207
1424
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
9.4
88
446
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
2.2
9.2
97
515
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
9.1
85
430
M25.5
ICD-10 Finland
Pain in joint
1.9
9.1
175
1153
N06AX21
ATC
duloxetine; oral
2.3
9.0
73
347
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.6
8.8
29
84
N06AX16
ATC
venlafaxine; oral
2.2
8.8
88
458
N76.0
ICD-10 Finland
Acute vaginitis
2.3
8.7
70
332
N06AX12
ATC
bupropion; oral
2.5
8.6
56
241
N03AX12
ATC
[U] gabapentin; oral
2.3
8.5
74
362
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
8.5
112
644
HAB20
NOMESCO Finland
Excision of lactiferous duct
91.9
8.4
9
*
M79.7
ICD-10 Finland
Fibromyalgia
3.4
8.4
30
92
N05AH04
ATC
quetiapine; oral
2.1
8.4
98
540
M03BC01
ATC
orphenadrine (citrate); systemic
2.0
8.4
126
760
C07AA05
ATC
propranolol; systemic
2.0
8.3
120
713
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
8.3
91
490
ULA02
NOMESCO Finland
Kolposcopy
2.1
8.0
84
444
SPAT1263
SPAT
Sampling
1.8
8.0
183
1260
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
3.1
7.9
34
117
ZXA05
NOMESCO Finland
Left side
2.1
7.9
81
424
N05BA04
ATC
oxazepam; oral
1.9
7.7
127
786
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
7.7
97
548
UJF32
NOMESCO Finland
Coloscopy
2.0
7.7
92
510
D24
ICD-10 Finland
Benign neoplasm of breast
6.4
7.6
19
31
R52.9
ICD-10 Finland
Pain, unspecified
2.4
7.6
53
235
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
7.6
56
255
Z48.0
ICD-10 Finland
Attention to surgical dressings and sutures
4.5
7.5
18
41
R06AE07
ATC
cetirizine; oral
1.8
7.5
216
1584
M79.1
ICD-10 Finland
Myalgia
2.0
7.4
93
523
N06AX11
ATC
mirtazapine; oral
1.8
7.4
155
1033
H02AB06
ATC
prednisolone; systemic
1.8
7.4
192
1364
N05AA02
ATC
levomepromazine; systemic
4.0
7.3
21
55
XLA10, ,
NOMESCO Finland
2.9
7.3
35
128
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.1
7.3
83
451
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
5.8
7.2
19
34
J01DA01
ATC
[U] cefalexin
1.8
7.1
268
2112
XF404
NOMESCO Finland
Ambulatory ECG
3.0
7.0
32
114
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.2
7.0
62
305
G43.9
ICD-10 Finland
Migraine, unspecified
2.3
7.0
56
264
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.0
7.0
81
443
Z71.8
ICD-10 Finland
Other specified counselling
1.8
6.9
174
1216
R53
ICD-10 Finland
Malaise and fatigue
1.8
6.9
125
792
J01MA02
ATC
ciprofloxacin; systemic
1.8
6.9
136
885
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
6.9
67
342
N64.4
ICD-10 Finland
Mastodynia
3.2
6.9
28
93
A02BC05
ATC
esomeprazole; systemic
1.8
6.8
164
1131
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.2
6.8
59
288
R03AC02
ATC
salbutamol; inhalant
1.8
6.8
255
1993
J01AA02
ATC
doxycycline; systemic
1.9
6.7
316
2635
N05CF01
ATC
zopiclone; oral
1.8
6.7
119
749
C07AB07
ATC
bisoprolol; oral
1.8
6.7
139
917
XQ800
NOMESCO Finland
Prick test
2.4
6.7
47
209
SPAT1283
SPAT
Restricted health certificate
1.8
6.6
117
736
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
6.6
108
663
E0000UV, ,
ATC
1.7
6.6
188
1357
O20.0
ICD-10 Finland
Threatened abortion
3.2
6.6
26
85
A11
ICPC
Chest pain NOS
2.8
6.6
33
124
N02BE01
ATC
paracetamol; systemic, rectal
2.4
6.6
367
3240
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
6.6
85
483
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.7
6.5
34
131
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.4
6.5
44
193
HA5CB
NOMESCO Finland
Galactography
70.9
6.4
7
*
F61.0
ICD-10 Finland
Mixed personality disorders
4.2
6.4
17
42
R20.2
ICD-10 Finland
Paraesthesia of skin
2.4
6.4
46
207
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
6.4
47
214
G44.2
ICD-10 Finland
Tension-type headache
1.9
6.3
85
489
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
1.9
6.3
83
474
M79.6
ICD-10 Finland
Pain in limb
1.7
6.3
196
1444
G02CB04
ATC
quinagolide; oral
+∞
6.3
6
*
FP1B5, ,
SPAT
5.2
6.3
18
36
R07.3
ICD-10 Finland
Other chest pain
2.4
6.2
45
203
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.3
6.2
46
210
R06.0
ICD-10 Finland
Dyspnoea
1.8
6.1
104
644
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
6.1
98
596
A02BC02
ATC
pantoprazole; systemic
1.7
6.1
265
2125
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
1.9
6.1
79
448
R52.2
ICD-10 Finland
Other chronic pain
3.4
6.1
22
68
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.5
6.1
21
63
J01DB01
ATC
cefalexin; oral
2.1
6.1
348
3032
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.8
6.1
31
118
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
2.0
6.0
73
405

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
112
290
4.96
41.61
2.3
1.7
558.52
313.11
mu/l
0.45
103
261
47
76
6.87
28.56
2.6
1.6
311.92
356.38
mu/l
0.56
36
65
27
21
13.69
15.90
1.6
1.8
—
—
—
0
0
171
1018
2.18
12.72
3.4
2.3
64.53
61.08
u/l
0.10
157
949
255
1861
2.00
10.07
4.4
4.1
6.07
6.30
mmol/l
1.03
238
1686
218
1510
1.96
10.00
5.6
5.9
1.21
1.22
mmol/l
0.59
202
1299
276
2084
2.02
9.73
11.4
8.7
3.99
3.91
e9/l
0.28
240
1823
234
1696
1.90
9.00
6.1
5.5
9.43
9.34
umol/l
0.05
226
1612
251
1864
1.92
8.93
7.2
6.0
0.04
0.04
e9/l
0.78
220
1635
256
1918
1.91
8.81
7.0
6.0
1.94
2.00
e9/l
0.37
233
1731
78
386
2.26
8.78
2.2
2.1
369.58
370.26
nmol/l
0.01
71
368
250
1861
1.90
8.75
7.2
6.0
0.51
0.52
e9/l
0.54
220
1636
187
1278
1.86
8.49
3.5
3.1
30.17
26.91
u/l
0.88
176
1224
189
1314
1.82
7.97
3.8
4.4
37.62
37.14
g/l
0.74
182
1256
190
1325
1.82
7.92
4.9
5.3
1.21
1.22
mmol/l
1.30
182
1231
138
877
1.87
7.72
4.7
3.2
1.02
1.02
kg/l
0.44
94
568
254
1944
1.83
7.68
7.4
6.3
0.18
0.17
e9/l
0.44
229
1731
387
3473
3.72
7.41
15.8
11.6
139.50
139.63
mmol/l
0.59
381
3407
387
3478
3.68
7.29
16.0
11.6
3.88
3.90
mmol/l
0.82
381
3400
41
164
2.67
7.27
1.2
1.3
14.42
12.19
u/l
0.34
32
136
101
602
1.90
6.78
2.3
2.5
71.18
89.15
ug/g
0.58
85
477
71
377
2.07
6.61
1.7
1.5
—
—
—
0
0
357
3131
2.21
6.25
6.8
5.0
14.34
14.28
pmol/l
0.24
345
2962
137
916
1.75
6.25
3.6
3.8
7.40
7.40
ph
0.59
95
629
133
885
1.75
6.15
1.6
1.4
17.14
26.94
iu/ml
1.06
47
268
279
2269
1.74
6.12
3.7
3.3
71.71
64.26
ug/l
0.71
270
2163
162
1141
1.70
6.09
7.3
5.7
—
—
—
0
0
228
1758
1.68
6.08
7.8
6.0
29.17
29.48
%
0.18
216
1689
310
2611
1.80
5.87
8.8
7.0
71.93
73.57
u/l
0.27
297
2480
46
216
2.27
5.81
2.2
1.2
—
—
—
0
0
225
1743
1.66
5.78
7.6
5.8
57.13
56.64
%
0.29
216
1674
220
1701
1.64
5.64
7.7
6.0
7.83
8.23
%
1.76
208
1615
219
1694
1.64
5.58
7.7
6.0
0.69
0.69
%
0.06
207
1596
219
1696
1.64
5.54
7.6
5.9
2.72
2.72
%
0.01
207
1605
93
573
1.81
5.52
2.5
2.4
465.50
518.55
mosm/kgh2o
1.75
82
506
161
1155
1.65
5.52
9.7
7.4
1.10
1.08
inr
0.27
133
948
123
826
1.70
5.40
1.5
1.3
3.16
10.86
u/ml
2.31
44
351
149
1061
1.64
5.19
3.1
2.3
—
—
—
0
0
68
393
1.88
4.92
3.2
2.1
6134.61
7275.68
u/l
0.08
16
173
64
364
1.90
4.86
1.3
1.2
—
—
—
0
0
203
1576
1.58
4.85
2.3
2.0
—
—
—
0
0
244
1977
1.59
4.85
4.3
3.4
0.00
0.00
estimate
0.50
47
414
51
269
2.03
4.81
3.3
1.5
—
—
—
0
0
155
1133
1.60
4.77
3.1
3.1
2.35
2.35
mmol/l
0.04
144
1060
246
2003
1.58
4.74
4.4
3.5
0.00
0.01
estimate
0.50
48
403
245
1994
1.58
4.72
4.4
3.4
23.42
6.99
estimate
0.30
48
417
100
664
1.67
4.49
2.1
2.5
7.03
9.39
e6/l
0.67
91
596
154
1139
1.57
4.44
3.0
2.7
0.00
0.00
—
5
17
50
270
1.97
4.42
3.4
1.5
—
—
—
0
0
98
651
1.67
4.38
1.6
1.4
543.64
601.96
titre
0.09
22
143
75
463
1.76
4.37
1.3
1.4
24.54
25.03
iu/l
0.04
64
407
15
45
3.42
4.36
1.2
1.2
—
—
nmol/l
—
0
0
64
377
1.83
4.36
1.9
2.5
5.04
5.01
umol/l
0.01
51
319
47
250
2.00
4.34
3.5
1.5
—
—
—
0
0
27
114
2.47
4.33
3.9
1.5
—
—
—
0
0
50
273
1.95
4.29
3.4
1.5
—
—
—
0
0
27
115
2.44
4.26
1.1
1.1
2.28
2.67
u/ml
0.11
17
66
38
191
2.09
4.08
3.8
1.7
—
—
—
0
0
294
2539
1.58
4.02
5.5
4.1
—
1.92
—
0
5
151
1133
1.53
4.00
1.5
1.3
1.74
2.11
u/ml
0.16
36
332
304
2654
1.59
3.89
4.0
3.0
34.43
34.15
u/l
0.04
290
2556
54
314
1.83
3.83
3.8
2.0
6.26
6.19
ph
0.21
39
194
48
269
1.89
3.82
3.4
1.5
—
—
—
0
0
41
219
1.97
3.75
3.0
1.4
—
—
—
0
0
130
960
1.52
3.65
1.7
1.4
1.87
2.12
g/l
1.55
78
630
52
305
1.81
3.59
2.0
1.9
0.00
0.03
estimate
0.49
11
68
153
1172
1.49
3.59
2.5
2.0
—
—
—
0
0
71
457
1.67
3.54
2.7
2.5
4.93
4.82
e6/l
0.03
32
192
93
647
1.57
3.39
3.5
3.5
—
—
—
0
0
384
3613
2.27
3.32
17.0
11.4
14.90
18.67
mg/l
2.42
326
2862
171
1356
1.45
3.30
2.3
1.9
95.85
98.86
pmol/l
0.41
99
746
48
284
1.78
3.23
1.3
1.2
—
—
—
0
0
207
1711
1.43
3.15
3.0
2.5
72.70
75.20
nmol/l
0.68
195
1609
131
995
1.47
3.13
3.0
2.8
16.55
62.97
e6/l
1.99
106
718
12
35
3.50
3.13
1.2
2.0
24.61
21.49
ng/l
0.39
12
35
115
855
1.48
3.05
2.9
2.7
0.16
0.30
e6/l
1.06
90
586
18
75
2.47
3.01
2.4
2.5
3.10
1.89
index
—
10
35
20
88
2.34
2.99
1.1
1.1
5.79
0.95
u/ml
0.63
11
39
5
5
10.10
2.98
1.0
1.0
—
—
—
0
0
88
622
1.53
2.97
1.6
1.6
—
—
—
0
0
21
95
2.28
2.95
1.0
1.1
5.57
5.11
u/ml
0.05
15
49
27
136
2.06
2.93
2.9
2.5
1.02
1.02
ratio
0.48
21
128
106
783
1.48
2.89
2.1
2.4
286.95
301.62
umol/l
0.99
98
724
39
225
1.81
2.86
2.4
3.3
2.79
1.69
mmol/l
1.23
34
187
133
1033
1.43
2.78
3.4
2.8
11.15
18.97
ng/l
1.75
59
496
187
1542
1.40
2.77
4.2
3.2
0.03
0.04
estimate
0.16
35
356
192
1591
1.39
2.76
3.9
3.1
6.37
6.21
ph
1.07
108
917
197
1643
1.39
2.71
10.2
9.2
0.00
0.00
e9/l
0.81
166
1339
23
113
2.10
2.67
1.4
1.5
336.57
407.08
mg/l
1.13
23
106
67
456
1.56
2.67
3.6
3.3
4.18
5.23
e9/l
0.73
59
421
20
93
2.21
2.65
4.5
5.0
2.01
1.69
%
0.47
20
87
61
408
1.58
2.62
2.0
1.9
—
—
—
0
0
50
321
1.64
2.53
3.8
3.8
4.57
4.64
pmol/l
0.25
42
289
68
470
1.54
2.53
1.2
1.2
—
—
—
0
0
73
513
1.52
2.52
4.4
3.0
366.44
350.22
ng/l
0.02
41
277
373
3521
1.77
2.47
8.1
5.9
1.59
1.75
mu/l
2.99
366
3380
21
103
2.10
2.46
1.3
1.3
315.27
320.11
ug/g
0.04
11
56
49
316
1.63
2.44
4.1
5.8
103.78
104.85
mmol/l
1.25
49
316
49
316
1.63
2.44
2.5
2.2
29.31
32.96
u/l
0.40
36
261
113
872
1.41
2.41
2.2
1.7
0.67
0.83
mg/l
0.63
90
660
18
84
2.20
2.38
4.6
5.3
0.86
0.88
%
0.10
18
77
44
278
1.65
2.38
1.4
1.3
—
33.07
—
0
23
7
17
4.17
2.37
2.1
1.8
—
—
—
0
0
19
91
2.14
2.37
1.1
1.1
3.12
17.93
au/ml
—
5
31
132
1050
1.38
2.35
4.4
3.5
0.00
0.00
estimate
0.80
44
402
125
986
1.39
2.33
3.7
3.2
8.72
7.66
mmol/l
1.02
113
853
38
234
1.69
2.27
2.4
3.3
7.38
7.39
ph
0.32
19
131
110
854
1.40
2.25
1.7
1.5
19.11
21.50
nmol/l
1.10
101
755
204
1746
1.34
2.24
2.9
2.6
—
—
estimate
—
0
0
356
3340
1.55
2.18
4.9
4.1
5.61
5.62
mmol/l
0.05
346
3161
35
214
1.70
2.15
3.1
4.1
63.86
75.99
ng/l
0.76
27
193
120
955
1.36
2.10
2.4
2.1
2.52
2.56
mg/l
0.09
108
823
6
15
4.04
2.04
3.8
1.7
11.40
16.91
umol/l
—
6
15
130
1052
1.35
2.03
8.4
5.7
—
—
—
0
0
9
32
2.85
2.01
1.4
1.8
—
—
—
0
0
55
387
1.49
1.90
1.4
1.4
—
—
—
0
0
120
969
1.34
1.89
4.3
4.4
—
—
—
0
0
77
579
1.41
1.88
2.2
2.2
2.42
2.42
mmol/l
0.05
68
523
62
448
1.45
1.88
1.4
1.2
172.28
161.94
u/ml
0.07
20
184
57
406
1.47
1.86
1.4
1.3
—
—
—
0
0
28
169
1.71
1.82
1.1
1.2
—
—
—
0
0
39
257
1.57
1.82
1.3
1.4
219.46
269.10
miu/ml
0.51
15
133
9
35
2.61
1.81
1.1
1.3
69.78
87.97
mmol/l
—
9
30
59
426
1.45
1.80
1.8
1.6
1125.91
1108.57
nmol/l
0.06
50
330
8
29
2.79
1.80
1.0
1.1
—
—
—
0
0
6
18
3.37
1.75
1.2
1.3
—
—
—
0
0
18
97
1.90
1.69
3.1
4.0
36.81
36.94
°c
0.92
18
97
42
287
1.52
1.68
2.9
1.7
—
—
—
0
0
20
112
1.83
1.67
1.2
1.2
—
—
—
0
0
7
25
2.83
1.65
1.3
2.9
—
—
—
0
0
149
1263
1.28
1.62
4.1
3.4
55.47
52.09
e6/l
0.04
111
796
14
70
2.04
1.61
2.9
2.3
5.20
6.63
pmol/l
0.73
14
70
14
70
2.04
1.61
1.4
2.8
7.42
7.41
ph
0.17
14
70
339
3195
1.38
1.59
5.8
4.9
36.81
37.33
mmol/mol
0.62
329
3049
21
122
1.76
1.58
5.4
6.9
24.77
24.70
mmol/l
0.04
21
117
14
71
2.01
1.55
4.3
6.2
1.14
1.20
mmol/l
0.14
14
62
20
326
0.59
1.48
3.9
3.4
—
—
—
0
0
26
164
1.63
1.47
1.8
2.2
3.89
4.63
iu/l
—
9
72
31
205
1.55
1.45
1.5
2.2
8.33
8.96
iu/ml
—
6
50
19
111
1.75
1.41
3.5
5.0
—
—
—
0
0
17
96
1.80
1.41
8.0
6.3
—
—
—
0
0
11
53
2.11
1.39
4.5
2.9
—
—
—
0
0
39
274
1.47
1.39
3.0
4.7
0.20
0.07
%
—
5
58
22
135
1.67
1.39
1.4
1.3
—
—
—
0
0
9
41
2.22
1.38
1.6
1.1
31.07
27.61
mg/l
—
9
29
33
225
1.51
1.36
1.1
1.1
—
—
—
0
0
5
17
2.96
1.36
1.0
1.2
120.80
154.82
nmol/l
—
5
17
16
91
1.79
1.31
1.4
1.5
—
—
—
0
0
6
24
2.52
1.31
1.2
1.8
—
—
—
0
0
33
228
1.49
1.29
1.0
1.1
—
—
—
0
0
389
3787
1.73
1.28
15.5
10.3
—
—
—
0
0
148
1284
1.24
1.27
2.0
2.1
—
—
—
0
0
139
1199
1.24
1.26
3.5
2.8
0.00
0.02
estimate
1.34
37
352
40
289
1.43
1.25
3.1
4.6
0.33
0.95
%
—
6
73
39
281
1.43
1.24
3.5
5.1
0.00
0.22
%
—
5
58
9
45
2.02
1.24
1.3
1.3
—
—
—
0
0
79
638
1.30
1.23
1.5
1.5
440.46
49911940.09
pmol/l
1.33
70
565
8
39
2.07
1.16
1.3
1.1
169.38
190.10
mg/l
—
8
30
17
106
1.63
1.04
1.8
1.3
—
—
—
0
0
31
222
1.43
1.04
1.5
1.2
—
—
—
0
0
18
117
1.56
0.95
2.6
2.1
—
—
—
0
0
21
142
1.51
0.94
2.5
2.0
—
—
—
0
0
6
28
2.16
0.92
1.0
1.4
—
—
—
0
0
19
127
1.52
0.90
1.2
1.1
—
—
—
0
0
22
152
1.47
0.90
1.6
1.8
—
—
—
0
0
30
221
1.39
0.88
3.8
4.5
16.66
7.51
ug/l
0.29
22
168
58
473
1.26
0.86
1.3
1.2
—
—
—
0
0
17
113
1.53
0.83
1.1
1.2
—
—
—
0
0
36
277
1.33
0.82
3.0
4.4
0.33
0.82
%
—
6
66
6
32
1.89
0.82
1.0
1.1
—
—
—
0
0
8
47
1.72
0.81
1.3
1.2
—
—
—
0
0
35
271
1.32
0.77
2.2
2.4
0.24
0.23
g/l
0.44
30
261
24
176
1.39
0.74
2.2
1.6
0.34
0.27
mg/l
0.19
12
67
13
84
1.57
0.72
1.5
1.2
3.13
6.28
u/ml
—
8
29
32
248
1.32
0.71
1.3
1.4
—
—
—
0
0
17
118
1.46
0.70
2.0
1.7
—
10.92
—
0
5
12
77
1.58
0.69
1.2
1.2
—
—
—
0
0
10
61
1.66
0.69
1.1
1.1
—
—
—
0
0
7
42
1.68
0.68
1.3
2.8
8.34
9.34
kpa
—
7
42
7
42
1.68
0.68
1.3
2.8
4.99
5.01
kpa
—
7
42
5
27
1.86
0.68
2.4
1.7
0.49
1.19
promille
—
5
21
7
43
1.64
0.67
1.0
1.7
16.70
7.44
u/ml
—
7
43
19
137
1.41
0.66
1.6
1.6
—
—
—
0
0
33
261
1.29
0.65
3.6
3.4
7.29
7.35
ph
0.51
25
185
120
1085
1.15
0.62
1.8
1.8
—
—
—
0
0
10
64
1.58
0.59
1.1
1.0
—
—
—
0
0
23
176
1.33
0.58
4.0
2.7
76.72
74.81
e9/l
0.08
12
120
49
416
1.20
0.54
1.4
1.4
—
—
—
0
0
31
253
1.24
0.50
5.9
6.9
5.13
5.10
kpa
0.08
31
244
31
253
1.24
0.50
5.9
6.9
15.38
13.42
kpa
0.50
31
245
91
820
1.14
0.49
3.5
3.6
38.29
45.52
mg/l
0.22
50
532
7
107
0.65
0.49
5.0
2.8
1.21
1.33
mg/l
—
7
96
7
48
1.47
0.47
1.1
1.1
—
—
—
0
0
19
147
1.31
0.46
1.4
1.5
0.42
0.42
nmol/l
0.00
14
127
65
576
1.15
0.45
1.9
2.0
—
—
—
0
0
45
520
0.85
0.45
1.3
1.3
—
—
—
0
0
20
157
1.29
0.44
3.0
5.7
25.91
24.72
mmol/l
0.68
20
157
8
57
1.41
0.42
3.5
4.0
3.76
3.76
mmol/l
—
8
57
8
58
1.39
0.41
1.1
1.5
—
60.58
—
0
6
30
250
1.22
0.41
5.2
6.9
1.89
0.90
mmol/l
1.00
20
202
30
251
1.21
0.40
6.2
7.0
7.42
7.41
ph
0.30
21
138
14
106
1.33
0.39
1.6
3.8
572.43
335.18
mg/l
—
7
44
20
160
1.26
0.39
2.0
2.0
0.00
0.00
estimate
—
10
58
50
440
1.16
0.39
1.4
1.3
—
—
—
0
0
9
68
1.33
0.38
3.2
4.0
1.30
1.35
mmol/l
—
9
68
16
125
1.29
0.37
6.8
8.4
15.41
16.12
%
0.55
16
120
5
37
1.36
0.37
1.4
2.6
—
—
—
0
0
6
41
1.47
0.36
1.3
1.2
—
—
—
0
0
21
254
0.82
0.35
1.5
1.5
—
—
—
0
0
19
154
1.25
0.34
2.1
3.3
4.70
5.13
kpa
1.70
19
148
18
221
0.81
0.34
1.1
1.1
0.84
0.87
g/l
0.27
18
221
346
3518
0.89
0.34
4.8
4.2
1.50
1.55
mmol/l
1.73
336
3358
6
45
1.34
0.34
1.5
1.3
—
—
—
0
0
22
263
0.83
0.33
1.5
1.6
—
—
—
0
0
88
824
1.09
0.26
4.0
4.2
9.40
8.98
mg/mmol
0.03
48
504
22
252
0.87
0.22
1.5
1.5
1.09
1.28
mm
1.83
16
178
5
41
1.22
0.22
1.0
1.3
—
—
—
0
0
5
41
1.22
0.22
1.0
1.3
—
—
—
0
0
5
41
1.22
0.22
1.0
1.3
—
—
—
0
0
5
41
1.22
0.22
1.0
1.3
—
—
—
0
0
335
3303
1.08
0.22
4.0
3.6
1.28
1.21
mmol/l
0.99
320
3137
5
42
1.19
0.21
1.2
1.2
—
—
—
0
0
5
43
1.16
0.21
2.6
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
48
1.25
0.20
1.5
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
0.00
—
0
14
12
144
0.83
0.20
8.0
8.2
0.73
0.61
%
0.58
12
144
6
50
1.20
0.20
1.2
1.2
—
—
—
0
0
50
464
1.09
0.19
1.5
1.6
3.54
3.43
mmol/l
0.25
31
330
162
1672
0.95
0.18
2.5
2.6
—
—
—
0
0
7
62
1.13
0.17
2.3
1.3
—
—
—
0
0
7
63
1.11
0.17
2.9
2.0
—
—
—
0
0
23
206
1.12
0.16
5.1
7.1
—
—
—
0
0
36
390
0.92
0.16
1.7
1.6
—
—
—
0
0
19
214
0.88
0.16
1.1
1.1
1.45
1.61
g/l
2.60
19
214
7
90
0.77
0.14
2.3
3.1
56.86
58.58
%
—
7
90
93
896
1.05
0.13
1.7
1.8
—
—
—
0
0
19
172
1.11
0.11
1.5
1.7
1.97
9.24
u/ml
—
6
41
125
1283
0.96
0.11
1.6
1.7
—
—
—
0
0
13
146
0.89
0.10
7.5
8.2
2.10
1.18
%
0.74
13
146
5
44
1.14
0.10
3.0
1.9
—
—
—
0
0
76
734
1.04
0.10
1.7
1.4
—
—
—
0
0
6
56
1.07
0.08
1.2
1.9
52.50
59.26
%
—
6
56
5
63
0.79
0.08
1.4
1.1
—
—
—
0
0
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
150
1482
1.02
0.04
1.9
1.9
1.54
1.33
mmol/l
1.57
135
1320
354
3553
0.97
0.04
5.2
4.6
2.90
2.86
mmol/l
0.38
345
3397
352
3530
0.98
0.02
4.9
4.3
4.80
4.83
mmol/l
0.37
342
3389
54
550
0.98
0.02
1.6
1.6
864.37
959.75
mu/l
0.50
41
455
12
117
1.03
0.00
1.3
1.3
—
—
—
0
0
15
147
1.02
0.00
6.6
8.2
93.29
95.15
%
0.77
15
147
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
66.11
—
0
9
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
1.18
—
0
8
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
7
71
0.99
-0.00
2.0
3.2
4.77
4.33
e9/l
—
7
71
0
5
0.00
-0.00
0.0
1.0
—
0.04
—
0
5
0
7
0.00
-0.00
0.0
4.4
—
16.57
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
0.22
—
0
6
10
100
1.00
-0.00
2.8
3.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
77
0.91
-0.00
1.1
1.1
—
—
—
0
0
12
120
1.00
-0.00
1.3
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
6
60
1.00
-0.00
1.5
2.3
8.75
8.26
kpa
—
6
60
12
120
1.00
-0.00
1.4
1.1
—
—
—
0
0
8
83
0.96
-0.00
1.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
1.40
—
0
6

Mortality – FinRegistry

Association

Association between endpoint N14_GALACTORRHEA and mortality.

Females

Parameter HR [95% CI] p-value
N14_GALACTORRHEA 1.223 [0.94, 1.58] 0.127
Birth year 0.998 [0.99, 1.01] 0.625

During the follow-up period (1.1.1998 — 31.12.2019), 61 out of 1805 females with N14_GALACTORRHEA died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_GALACTORRHEA.

N-year risk Females Males
1 0.156% No data
5 0.657% No data
10 1.85% No data
15 3.8% No data
20 6.645% No data

Relationships between endpoints

Index endpoint: N14_GALACTORRHEA – Galactorrhea

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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