Complications of anaesthesia during labour and delivery

O15_LABOUR_ANEST_COMPLIC

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule only females	313377
2. Check conditions None	313377
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O74 Hospital discharge: ICD-9 — 668 Hospital discharge: ICD-8 — 6629 Cause of death: ICD-10 — O74 Cause of death: ICD-9 — 668 Cause of death: ICD-8 — 6629 2 out of 7 registries used, show all original rules.	159
4. Check minimum number of events None	159
5. Include endpoints None	159
6. Filter based on genotype QC (FinnGen only)	145

Control definitions (FinnGen only)

Control exclude: O15_COMPLIC_LAB_DELIV

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5
Parent code in ICD-10: O60-O75
Name in latin: Complicationes ex anaesthesia intra labores/partum

NAME	O15_LABOUR_ANEST_COMPLIC
CONTROL_EXCLUDE	O15_COMPLIC_LAB_DELIV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O74
HD_ICD_9	668
HD_ICD_8	6629
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O74
COD_ICD_9	668
COD_ICD_8	6629
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Complications of anaesthesia during labour and delivery based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1122	1122	-
Only index persons	1109	1109	-
Unadjusted period prevalence (%)
Whole population	0.03	0.03	-
Only index persons	0.04	0.04	-
Median age at first event (years)
Whole population	-	29.82	-
Only index persons	-	29.87	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	145	145	-
Unadjusted period prevalence (%)	0.05	0.05	-
Median age at first event (years)	30.48	30.48	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
149: Matched controls
1490

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O74.5

ICD-10 Finland

Spinal and epidural anaesthesia-induced headache during labour and delivery

+∞

116.4

TAB22

NOMESCO Finland

Stoppin epidural fluid escape with coagulated blood

199.2

85.0

O68.0

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly

+∞

24.7

O81.4

ICD-10 Finland

Vacuum extractor delivery

28.7

23.8

ZXD05

NOMESCO Finland

Urgent procedure

4.9

21.2

277

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

5.9

18.3

MAE00

NOMESCO Finland

Outlet vacuum delivery

22.8

17.6

O74.0

ICD-10 Finland

Aspiration pneumonitis due to anaesthesia during labour and delivery

+∞

15.9

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

4.0

15.6

296

WX321

NOMESCO Finland

Acute spinal anesthesia for delivery

5.7

15.3

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

3.6

13.2

323

Z39.2

ICD-10 Finland

Routine postpartum follow-up

3.5

12.8

286

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

3.4

12.2

300

O99.80

ICD-10 Finland

The fear of childbirth

4.8

11.9

WX306

NOMESCO Finland

Lumbar epidural anesthesy

4.7

11.7

Z36.3

ICD-10 Finland

Antenatal screening for malformations using ultrasound and other physical methods

3.3

11.4

506

SPAT1379

SPAT

Health check-up of pregnant person

3.4

11.2

237

O63.1

ICD-10 Finland

Prolonged second stage (of labour)

+∞

10.5

MA2JE

NOMESCO Finland

Ultrasound screening of fetal nuchal translucency

3.4

10.3

176

W78

ICPC

Pregnancy

3.0

10.1

373

O72.2

ICD-10 Finland

Delayed and secondary postpartum haemorrhage

+∞

9.5

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

3.3

9.2

162

O82.10

ICD-10 Finland

Delivery by emergency caesarean section

9.6

9.1

Z3232

NOMESCO Finland

Midwife

3.2

8.7

174

O60

ICD-10 Finland

Preterm labour and delivery

+∞

8.4

O70.1

ICD-10 Finland

Second degree perineal laceration during delivery

+∞

8.4

Z34.0

ICD-10 Finland

Supervision of normal first pregnancy

2.8

8.1

248

WX307

NOMESCO Finland

Obstetric epidural analgesia

2.9

7.5

188

O74.8

ICD-10 Finland

Other complications of anaesthesia during labour and delivery

+∞

7.3

6688X

ICD-9 Finland

Complications of the administration of anaesthetic or other sedation in labour and delivery, Other complications of anaesthesia or other sedation in labour and delivery

+∞

7.3

O64.0

ICD-10 Finland

Obstructed labour due to incomplete rotation of fetal head

+∞

7.3

SPAT1380

SPAT

Postpartum check-up

2.8

7.3

204

O24.4

ICD-10 Finland

Diabetes mellitus arising in pregnancy

3.0

7.2

146

SPAT1197

SPAT

Extensive health check-up of expecting family

2.5

6.4

282

ZXE00

NOMESCO Finland

One hour or less

2.4

6.4

409

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

3.0

6.3

125

O68.8

ICD-10 Finland

Labour and delivery complicated by other evidence of fetal stress

+∞

6.3

Z34.9

ICD-10 Finland

Supervision of normal pregnancy, unspecified

2.6

6.2

226

G43.1

ICD-10 Finland

Migraine with aura [classical migraine]

3.0

6.2

126

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

234

2.55

6.19

1.8

1.5

1100.74

1040.04

mu/l

0.16

195

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

444

2.26

5.62

2.3

1.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

132

2.70

5.17

1.6

1.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

642

2.19

5.04

9.3

4.5

5.97

6.23

mmol/l

0.56

585

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

601

2.13

4.82

3.7

2.5

—

estimate

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

114

2.55

4.06

1.5

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

102

2.61

3.99

1.6

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

118

2.46

3.78

1.6

1.4

1.23

1.12

ratio

0.29

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

118

2.46

3.78

1.6

1.4

1.15

1.37

ratio

0.45

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

118

2.46

3.78

1.6

1.4

0.93

0.99

ratio

0.56

(3043238) Trisomy 21 risk [Likelihood] in Fetus

106

2.51

3.69

1.6

1.5

—

(3003694) ABO and Rh group [Type] in Blood

480

1.92

3.69

2.0

1.7

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

3.02

3.65

1.3

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

381

1.91

3.48

2.9

2.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

8.86

3.29

3.3

1.3

93.42

89.77

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

107

2.36

3.17

2.3

1.7

—

(3044290) Cell count panel - Cerebral spinal fluid

3.89

2.94

1.0

1.1

—

(3026389) Candida sp identified in Specimen by Organism specific culture

3.62

2.75

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

122

2.15

2.69

2.0

1.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.22

2.63

1.4

—

(3019977) pH of Arterial blood

2.40

2.55

22.0

10.3

7.40

7.41

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

562

1.67

2.46

2.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

295

1.75

2.40

3.4

3.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

133

1178

2.20

2.37

4.6

4.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

2.20

2.34

1.9

1.5

51.74

56.30

ug/l

0.24

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

378

1.67

2.26

2.9

2.8

—

(3021601) Nitrite [Presence] in Urine by Test strip

707

1.64

2.26

4.3

3.2

0.00

0.01

estimate

0.50

152

(3026008) Bacteria identified in Urine by Culture

370

1.67

2.24

3.4

2.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.81

2.18

1.1

—

(3035350) Ketones [Presence] in Urine by Test strip

714

1.61

2.11

4.4

3.2

0.00

estimate

-0.00

150

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

5.13

2.08

1.6

1.4

—

(3009261) Glucose [Presence] in Urine by Test strip

717

1.60

2.05

4.4

3.2

0.00

estimate

-0.00

145

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

282

1.68

2.03

3.3

1.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

424

1.60

2.01

2.1

1.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

168

1.82

1.98

3.4

2.3

3202.69

57.61

ng/l

0.47

(40761535) Cells panel - Urine sediment

2.27

1.95

2.5

3.4

—

(3018095) Leukocytes [#/volume] in Urine

446

1.58

1.92

3.0

3.4

44.10

31.68

e6/l

0.22

271

(3030467) Casts [#/volume] in Urine by Automated count

312

1.63

1.92

2.7

2.6

0.17

0.22

e6/l

0.22

207

(4024509) Urine culture

2.50

1.90

1.7

1.6

—

(4034850) Laboratory test

2.96

1.89

4.1

4.0

—

(3029937) Albumin [Presence] in Urine by Test strip

375

1.59

1.88

5.0

3.4

0.00

0.01

estimate

0.50

148

(3037467) Urinalysis macro (dipstick) panel - Urine

108

921

1.63

1.88

5.7

3.7

—

(40767503) Oxygen content in Capillary blood by calculation

4.27

1.84

3.6

1.8

17.38

15.94

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

198

1.71

1.78

1.7

1.9

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

2.59

1.77

1.0

1.1

—

(1616796) Gas panel - Central venous blood

3.43

1.76

2.0

1.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

319

1.59

1.74

2.6

2.9

39.27

14.06

ng/l

0.73

126

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

3.94

1.73

1.0

1.2

—

(3002582) Erythrocytes [#/volume] in Urine

356

1.56

1.70

2.8

12.71

126.10

e6/l

0.74

249

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

3.24

1.68

2.0

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.89

1.67

1.0

—

(3015736) pH of Urine

591

1.50

1.65

3.4

2.9

6.36

6.24

0.39

338

(3001019) Free T4 and TSH panel - Serum or Plasma

138

1.79

1.63

1.7

1.4

—

(3027315) Oxygen [Partial pressure] in Blood

3.66

1.63

5.0

1.6

9.88

9.32

kpa

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

3.66

1.63

1.0

1.1

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.66

1.63

5.0

1.6

4.96

5.11

kpa

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

2.58

1.62

1.0

1.3

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

3.08

1.60

1.2

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.36

1.59

14.6

8.7

24.20

24.93

mmol/l

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.41

1.53

3.8

2.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

3.41

1.53

1.0

1.1

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

2.52

1.51

1.1

1.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.12

1.48

1.4

1.7

—

(3019060) Gas panel - Arterial blood

2.39

1.46

12.0

5.3

—

(3023410) Appearance of Cerebral spinal fluid

3.20

1.45

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.20

1.45

1.0

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

104

1.83

1.44

2.4

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.90

1.37

2.9

3.0

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.56

1.31

1.0

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

100

1.79

1.30

2.4

1.4

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

2.84

1.29

1.4

1.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

101

1.77

1.26

20.1

7.9

104.12

105.16

mmol/l

0.51

101

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

166

1.61

1.25

1.0

1.3

93.94

158.48

u/ml

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

183

1.58

1.25

2.4

2.2

0.63

0.88

e6/l

0.41

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

112

0.43

1.18

10.0

3.5

31.60

32.00

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

111

1.71

1.18

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.32

1.12

2.7

1.3

—

(40768797) Stomach Pathology biopsy report

163

1.56

1.10

1.2

1.1

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.18

1.07

1.9

1.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.02

1.06

28.6

13.6

95.44

95.30

—

(3034770) Mitochondria Ab [Titer] in Serum

2.11

1.04

1.1

1.2

—

(3020891) Body temperature

2.11

1.04

2.3

4.6

36.84

36.97

°c

—

(40768443) Skin Pathology biopsy report

2.11

1.04

1.0

1.1

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.97

1.04

28.4

13.3

1.29

1.19

—

(3032773) Endomysium IgG Ab [Titer] in Serum

2.32

1.04

1.0

1.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

316

1.41

1.03

1.2

1.3

17.05

20.61

iu/ml

0.17

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

354

1.39

1.00

1.7

2.2

—

(3012516) Albumin [Mass/volume] in Urine

237

1.45

0.99

3.8

3.6

33.46

40.79

mg/l

0.13

157

(3019150) Specific gravity of Urine by Refractometry

318

1.40

0.99

4.3

3.1

1.01

1.02

kg/l

1.01

199

(3025941) Bacteria identified in Stool by Culture

1.75

0.99

1.5

1.3

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.21

0.99

1.0

1.1

—

(42870588) Differential panel, method unspecified - Blood

383

1.37

0.98

10.6

5.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

125

1160

1.48

0.96

4.8

4.9

13.95

14.21

pmol/l

0.77

120

1088

(3018418) pH of Serum or Plasma

302

1.39

0.95

6.0

3.6

7.39

7.40

0.58

211

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

556

1.34

0.95

4.9

3.0

0.00

0.02

estimate

0.50

127

(3007853) Bacteria identified in Skin by Aerobe culture

144

1.53

0.93

1.7

1.5

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

153

1.51

0.92

1.5

1.7

—

(3006315) Basophils [#/volume] in Blood

666

1.32

0.91

7.5

5.9

0.04

e9/l

0.21

583

(3001604) Monocytes [#/volume] in Blood

667

1.32

0.90

7.6

5.8

0.50

0.52

e9/l

0.33

586

(3020682) Albumin/Creatinine [Ratio] in Urine

242

1.41

0.89

4.4

4.2

4.54

8.72

mg/mmol

0.56

149

(3038177) Helicobacter pylori Ab [Presence] in Serum

2.04

0.88

1.0

1.1

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.04

0.88

1.2

1.9

59.33

52.92

ng/l

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.82

0.86

31.4

13.7

0.90

0.68

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

156

1.48

0.85

3.8

2.6

0.85

0.82

mmol/l

0.56

150

(3013650) Neutrophils [#/volume] in Blood by Automated count

742

1.30

0.83

10.4

8.5

4.22

3.99

e9/l

0.50

652

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

149

1.48

0.81

2.5

1.5

—

(3027945) Reticulocytes/Erythrocytes in Blood

1.64

0.81

4.2

2.8

1.58

1.86

0.47

(40761536) Microorganisms panel - Urine sediment

132

1.50

0.81

6.7

3.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

500

1.30

0.79

2.1

1.9

98.44

94.79

pmol/l

0.36

274

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

457

0.75

0.78

2.6

2.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

491

1.30

0.78

1.5

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

125

1174

1.40

0.76

4.0

3.6

5.44

5.53

mmol/l

0.44

119

1108

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

2.12

0.75

2.0

1.7

7.72

7.81

mmol/l

—

(4035726) Immunohistochemistry procedure

1.60

0.74

1.8

1.3

—

(3000991) Gas panel - Venous blood

1.71

0.74

34.8

10.6

—

(3010421) pH of Blood

2.03

0.73

5.0

2.8

7.42

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

494

0.77

0.72

2.7

2.4

—

(3019198) Lymphocytes [#/volume] in Blood

692

1.27

0.71

7.6

5.8

1.89

1.95

e9/l

0.38

624

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.69

0.70

1.2

1.4

—

(3023368) Bacteria identified in Blood by Culture

216

1.36

0.70

4.4

3.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

451

1.27

0.67

1.3

0.58

2.61

u/ml

1.19

134

(3017143) Hepatitis C virus Ab [Presence] in Serum

264

1.32

0.66

2.2

1.5

—

(3014051) Protein [Presence] in Urine by Test strip

405

1.27

0.65

2.6

2.4

—

(3013115) Eosinophils [#/volume] in Blood

699

1.24

0.62

8.4

6.4

0.21

0.17

e9/l

0.34

621

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

1.63

0.62

2.0

1.3

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

167

1.37

0.61

2.7

3.1

1898.05

686.25

ng/l

0.43

129

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.57

0.61

1.4

1.3

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.61

0.0

1.5

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.61

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.60

0.0

1.2

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.59

0.0

1.4

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

104

966

1.25

0.58

3.8

3.9

8.69

8.43

mm/h

0.11

909

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

118

1113

1.29

0.57

4.8

4.3

35.44

36.48

mmol/mol

0.95

110

1066

(3035933) Granulocytes/Leukocytes in Blood

1.60

0.55

2.3

4.5

61.17

60.00

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

135

1301

1.40

0.52

16.8

10.9

17.77

17.15

mg/l

0.10

113

1013

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

101

1.43

0.51

1.4

1.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

514

1.21

0.49

2.3

1.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.50

0.48

2.9

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

258

1.25

0.47

3.2

2.6

115.38

61.70

ug/g

0.80

189

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.45

0.46

5.6

2.3

78.00

100.96

—

(3000492) Spirometry study

139

1.34

0.46

1.4

1.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

353

1.22

0.46

3.1

2.2

2.57

2.46

mg/l

0.18

319

(36660697) Celiac disease serology panel - Serum

140

0.69

0.46

1.1

1.2

—

(40768793) Breast Pathology biopsy report

1.39

0.44

1.6

1.3

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

1.44

0.44

1.5

1.0

0.86

0.82

g/l

0.25

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

298

1.23

0.44

1.5

2.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.63

0.43

1.6

1.3

—

(3035715) Granulocytes [#/volume] in Blood

1.58

0.42

2.6

4.4

3.27

4.46

e9/l

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.41

0.0

2.9

—

7.91

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.41

0.0

2.4

—

1.19

—

(3042936) Bacteria identified in Isolate by Culture

151

1.30

0.41

1.9

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.41

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

115

1.34

0.40

1.5

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.40

0.0

2.9

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

494

1.18

0.39

15.5

6.1

1.21

1.22

mmol/l

0.26

431

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.40

0.39

1.4

1.1

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.39

0.0

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.40

0.38

14.6

2.6

0.70

1.50

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.40

0.38

14.6

2.6

0.62

0.55

—

(3018010) Neutrophils/Leukocytes in Blood

624

1.17

0.37

8.1

5.3

59.02

56.97

1.05

599

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

117

1.31

0.37

2.9

2.1

30.91

59.86

u/ml

0.67

109

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

125

1208

1.22

0.33

11.7

9.2

96.50

96.30

ml/min/173m2

0.04

115

1090

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.32

0.33

13.5

2.5

22.58

24.43

mmol/l

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

139

1359

1.34

0.32

17.4

11.4

68.04

65.85

umol/l

0.43

139

1345

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.69

0.32

1.6

1.3

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.32

0.29

3.0

2.1

1.24

1.39

g/l

0.24

(3011288) Drugs identified in Urine by Screen method Nominal

117

0.75

0.28

2.3

1.9

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.28

0.28

9.8

2.8

4.20

4.82

kpa

—

(3028707) Methadone [Presence] in Urine by Screen method

0.66

0.26

1.2

1.6

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

170

1.20

0.26

2.5

2.3

3.00

6.67

e6/l

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.25

0.26

2.2

1.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

295

1.15

0.25

1.1

1.3

1.09

7.56

u/ml

—

132

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

1.30

0.25

1.1

1.0

1.75

1.61

g/l

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

1.33

0.23

1.2

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

239

1.16

0.23

1.6

1.7

3.38

3.23

ratio

0.25

172

(40760892) CBC W Ordered Manual Differential panel - Blood

376

1.12

0.22

4.4

5.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.20

0.21

1.6

2.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.21

0.0

1.0

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.1

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.21

0.0

1.9

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.21

0.0

3.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3000475) Leukocytes [#/volume] in Synovial fluid

0.00

0.21

0.0

1.2

—

1417.88

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

184

1.16

0.20

1.4

1.9

2.36

2.40

mmol/l

0.72

167

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.1

—

120.73

—

(3016879) Cocaine [Presence] in Urine

153

0.84

0.19

1.5

1.6

—

(21494755) Public health laboratory ask at order entry panel

206

1.14

0.17

1.5

1.3

—

(3025130) Human papilloma virus identified in Specimen

1.12

0.16

1.4

1.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

169

1.14

0.15

1.9

1.4

—

(3008898) HLA-B27 [Presence]

1.20

0.15

1.0

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

444

1.09

0.14

4.6

2.6

0.00

0.02

estimate

0.50

122

(1761868) Lipid panel - Serum or Plasma

614

1.07

0.13

2.2

2.3

—

(3020961) Endomysium IgA Ab [Titer] in Serum

104

1.17

0.13

1.2

1.1

—

143.33

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.19

0.12

2.3

1.8

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

201

1.11

0.12

2.5

2.1

1906.45

9282.79

u/l

1.58

(3023511) Choriogonadotropin [Units/volume] in Urine

126

0.86

0.12

1.2

1.4

—

(3022145) Colonoscopy Study observation

135

1.12

0.10

1.6

1.3

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.83

0.08

1.3

2.0

—

4.42

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.87

0.07

2.3

2.6

—

(1002224) Polysomnography panel

0.87

0.07

1.4

1.0

—

(3000494) Fungus identified in Specimen by Culture

158

1.09

0.06

1.5

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

109

1.11

0.06

5.1

4.4

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

131

0.91

0.06

1.5

—

(3002256) Pathology report gross observation

169

1.07

0.05

1.1

1.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

393

0.96

0.05

1.8

1.5

2.30

2.05

g/l

0.66

263

(3021589) Normoblasts [#/volume] in Blood

597

1.04

0.04

12.3

8.5

0.00

e9/l

0.74

483

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

200

1.06

0.04

1.4

1.6

3.59

3.21

mmol/l

0.86

136

(40768804) Tissue Pathology biopsy report

571

1.03

0.02

2.3

1.9

—

(40758558) Short blood count panel - Blood

373

1.03

0.01

5.0

5.5

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

116

0.94

0.01

2.3

—

11.31

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

144

1.05

0.00

1.9

1.8

390.07

381.87

nmol/l

0.07

134

(3027008) Opiates [Presence] in Urine

154

1.04

0.00

1.4

1.6

—

(3027944) Amphetamines [Presence] in Urine

154

1.04

0.00

1.4

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

324

1.02

0.00

1.6

1.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.01

0.00

1.3

1.4

—

(3028300) Cannabinoids [Presence] in Urine

155

1.04

0.00

1.4

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

155

1.04

0.00

1.4

1.6

—

(3003740) Influenza virus B Ag [Presence] in Specimen

1.02

-0.00

1.0

1.1

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

2.1

—

(3052912) Proteinase 3 IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.0

—

1.20

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.2

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.6

—

(43055514) Macroprolactin [Presence] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.92

-0.00

1.0

1.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.89

-0.00

1.2

1.1

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.2

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.0

—

9.56

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

-0.00

0.0

1.1

—

(3025378) Microscopic observation [Identifier] in Cervix by Cyto stain

0.00

-0.00

0.0

1.0

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.8

—

(3002523) Influenza virus A Ag [Presence] in Specimen

1.02

-0.00

1.0

1.1

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.2

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

-0.00

0.0

1.7

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.0

—

4.19

—

(3016845) Adenovirus Ag [Presence] in Specimen by Immunofluorescence

0.00

-0.00

0.0

1.1

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

176.20

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

496.25

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

-0.00

0.0

1.2

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.0

—

105.88

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

247.22

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.1

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

2.1

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

1.6

—

1.20

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

4.2

—

(3045209) Lutropin/Follitropin [Ratio] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

0.31

—

(3005880) Parainfluenza virus 3 Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3001556) Androgen free Index in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(40761873) Peanut recombinant (rAra h) 1 IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

0.06

—

(3006270) Folate [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

432.00

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.7

—

(3021578) Parainfluenza virus 2 Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

53.60

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

1.1

—

7.29

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3010464) Parainfluenza virus 1 Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint O15_LABOUR_ANEST_COMPLIC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_LABOUR_ANEST_COMPLIC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: O15_LABOUR_ANEST_COMPLIC – Complications of anaesthesia during labour and delivery

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Complications of anaesthesia during labour and delivery

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints