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Drug-induced systemic lupus erythematosus

EFO Endpoint Browser PheWeb

DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M32.0#

1 out of 7 registries used, show all original rules.

261

4. Check minimum number of events

None

261

5. Include endpoints

None

261

6. Filter based on genotype QC (FinnGen only)

237

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1257 1021 229
Only index persons 1098 918 180
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.01
Only index persons 0.03 0.03 0.01
Median age at first event (years)
Whole population 52.81 51.34 58.87
Only index persons 50.83 49.95 55.29

-FinnGen-

Key figures

All Female Male
Number of individuals 237 199 38
Unadjusted period prevalence (%) 0.06 0.07 0.02
Median age at first event (years) 46.87 46.11 50.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
243
Matched controls
2430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
307.7
242
*
P01BA02
ATC
hydroxychloroquine; oral
57.3
232.5
186
131
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
996.1
223.5
187
8
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
34.7
182.1
175
168
L04AX01
ATC
azathioprine; systemic
39.2
149.7
102
44
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
761.6
103.9
95
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
1364.0
96.9
88
*
L04AA06
ATC
mycophenolic acid; systemic
43.9
96.7
60
18
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
47.1
90.7
55
15
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
16.0
89.1
92
89
H02AB07
ATC
prednisone; oral
10.0
70.2
113
195
M05BA04
ATC
alendronic acid; oral
10.6
59.9
80
108
L04AX03
ATC
methotrexate; systemic
8.6
53.5
88
151
M32
ICD-10 Finland
Systemic lupus erythematosus
313.0
51.2
50
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
15.9
50.9
47
36
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.4
48.6
177
649
L01BA01
ATC
methotrexate; systemic
15.6
48.2
45
35
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.4
45.8
72
116
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.1
43.8
71
118
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
178.1
43.4
44
*
H02AB06
ATC
prednisolone; systemic
7.9
41.4
200
900
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
402.2
35.9
35
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.5
35.6
59
99
C08CA05
ATC
nifedipine; systemic
9.1
35.3
48
64
L93.0
ICD-10 Finland
Discoid lupus erythematosus
86.6
33.9
37
5
TPH04
NOMESCO Finland
Cathetrisation of vein
4.8
31.0
105
334
L88
ICPC
Rheumatoid/seropositive arthritis
9.7
30.9
39
47
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.9
30.0
173
815
B01AA03
ATC
warfarin; systemic
5.3
27.2
68
167
ZX120
NOMESCO Finland
Intravenous
5.6
26.2
59
132
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
277.3
25.2
25
*
R50.9
ICD-10 Finland
Fever, unspecified
4.5
24.4
76
222
M05BA07
ATC
risedronic acid; oral
9.8
22.9
28
32
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
+∞
22.2
21
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.7
21.7
61
163
M35.1
ICD-10 Finland
Other overlap syndromes
66.2
21.3
24
*
C03CA01
ATC
furosemide; systemic
3.7
21.0
100
389
L04AA01
ATC
[U] ciclosporin
46.2
20.9
25
6
G73.7*M32.1
ICD-10 Finland
Myopathy in systemic lupus erythematosus
+∞
20.1
19
*
H02AB04
ATC
methylprednisolone; systemic
4.1
20.1
69
214
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
6.1
19.9
38
72
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.6
18.9
84
309
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.4
18.7
56
156
E000001, ,
ATC
3.5
17.8
83
314
Z01.8
ICD-10 Finland
Other specified special examinations
3.3
17.3
90
364
A07AA02
ATC
nystatin; oral
5.3
17.0
37
79
D68.8
ICD-10 Finland
Other specified coagulation defects
19.7
16.9
25
14
D07AB08
ATC
desonide; topical
4.0
16.7
57
174
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
16.6
107
489
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.4
16.1
46
123
N02AX02
ATC
tramadol; systemic, rectal
2.9
15.2
143
794
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
15.1
65
231
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.9
15.0
51
155
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
38.7
14.7
18
5
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.6
14.5
56
185
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
7.0
14.4
23
36
J01MA12
ATC
levofloxacin; systemic
3.2
13.8
70
274
L04AD01
ATC
ciclosporin; systemic
15.0
13.5
22
16
B07.9
ICD-10 Finland
Verruca simplex
6.8
13.5
22
35
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.7
13.3
48
151
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.5
13.2
27
54
M05BX04
ATC
denosumab; parenteral
4.7
13.2
33
79
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
13.1
146
862
XF400
NOMESCO Finland
ECG with 12 standard connections
3.4
13.0
56
198
A02BC03
ATC
lansoprazole; oral
2.7
12.8
102
508
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.7
12.7
21
34
B01AB05
ATC
enoxaparin; parenteral
2.7
12.5
107
552
A02BC02
ATC
pantoprazole; systemic
3.4
12.4
202
1436
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
5.0
12.2
28
62
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
5.1
12.2
27
58
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
11.9
78
349
E0000UV, ,
ATC
2.5
11.4
137
820
XX9XE
NOMESCO Finland
Other ultrasound examination
18.2
11.4
17
10
Z50.1
ICD-10 Finland
Other physical therapy
4.8
11.3
27
62
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.0
11.2
35
99
R4120
NOMESCO Finland
Occupational therapy
3.9
11.2
36
104
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
6.1
11.2
20
35
J01MA14
ATC
moxifloxacin; systemic
3.6
11.1
40
125
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.2
11.0
31
81
J05AB01
ATC
aciclovir; systemic
2.6
10.9
90
450
J01FF01
ATC
clindamycin; systemic
2.5
10.7
94
483
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.4
10.6
42
140
J99.1*M32.1
ICD-10 Finland
Respiratory disorders in systemic: lupus erythematosus
+∞
10.5
10
*
J01MA02
ATC
ciprofloxacin; systemic
2.4
10.5
114
646
P01BA01
ATC
chloroquine; systemic
24.6
10.4
14
6
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.2
10.2
22
46
A02BC01
ATC
omeprazole; systemic
2.5
10.2
90
462
B01AB04
ATC
dalteparin; parenteral
5.0
10.0
22
47
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.9
9.9
31
88
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.3
9.3
25
63
Z3231
NOMESCO Finland
Registered nurse
2.4
9.2
87
458
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
16.4
9.1
14
9
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.5
9.1
23
55
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
9.1
50
201
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.5
9.1
73
356
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.5
9.1
34
109
H26.3
ICD-10 Finland
Drug-induced cataract
25.1
9.0
12
5
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.1
8.9
41
149
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.0
8.9
26
70
AA1AD
NOMESCO Finland
CT of head and brain
2.4
8.9
86
456
205
Kela drug reimbursment
Chronic hypertension
2.5
8.8
66
311
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.4
8.8
34
111
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
3.0
8.8
44
168
318
Kela drug reimbursment
Teriparatide
51.9
8.7
10
*
J01FA06
ATC
roxithromycin; oral
2.2
8.7
127
798
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
17.1
8.6
13
8
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
8.4
8.5
18
23
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.6
8.5
29
87
SAA03
NOMESCO Finland
Extended examination of mouth
2.2
8.4
122
761
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.5
8.4
21
50
N16.4*M32.1
ICD-10 Finland
Renal tubulo-interstitial disorders in systemic lupus erythematosus
+∞
8.4
8
*
R06.0
ICD-10 Finland
Dyspnoea
2.3
8.4
86
466
M05BB03
ATC
alendronic acid and colecalciferol; oral
8.0
8.3
18
24
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.5
8.2
60
278
C08CA02
ATC
felodipine; oral
3.6
8.2
28
84
L99
ICPC
Musculoskeletal disease other
7.7
8.1
18
25
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.7
8.1
49
207
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
22.9
8.1
11
5
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
22.9
8.1
11
5
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.1
8.0
23
61
J02AC01
ATC
fluconazole; systemic
2.2
8.0
139
926
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.8
7.9
25
71
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.1
7.9
36
130
I35.0
ICD-10 Finland
Aortic (valve) stenosis
4.8
7.8
18
40
H05AA02
ATC
teriparatide; parenteral
46.5
7.8
9
*
N32.9
ICD-10 Finland
Bladder disorder, unspecified
46.5
7.8
9
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.4
7.7
30
98
XCK00
NOMESCO Finland
Perimetry
3.8
7.6
24
68
J05AB11
ATC
valaciclovir; oral
2.4
7.5
59
282
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.8
7.5
42
170
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
7.5
40
158
ULA02
NOMESCO Finland
Kolposcopy
2.7
7.5
44
183
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
8.8
7.4
15
18
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.8
7.4
40
159
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
9.8
7.4
14
15
B02.9
ICD-10 Finland
Zoster without complication
3.2
7.4
30
101
M13.9
ICD-10 Finland
Arthritis, unspecified
3.3
7.3
29
96
N05.8
ICD-10 Finland
Unspecified nephritic syndrome, other
+∞
7.3
7
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
7.3
87
496
D07AC01
ATC
betamethasone; topical
2.1
7.3
107
661
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.6
7.3
45
192
Z3226
NOMESCO Finland
Physiotherapist
2.4
7.2
61
301
Z2221
NOMESCO Finland
Medical doctor
2.2
7.2
87
498
UJF30
NOMESCO Finland
Ileoscopy through colon
2.8
7.2
40
161
M05BA01
ATC
etidronic acid; systemic
20.8
7.2
10
5
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
12.5
7.2
12
10
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.2
7.1
30
103
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
10.5
7.1
13
13
WZC00
NOMESCO Finland
Treatment plan or consultation
2.1
7.1
104
641
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.1
7.1
31
109
C09AA02
ATC
enalapril; systemic
2.5
7.1
51
234
GD1AD
NOMESCO Finland
Thorax CT examination
3.7
6.9
22
63
X59
ICD-10 Finland
Exposure to unspecified factor
2.3
6.9
60
300
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
6.9
29
100
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
2.5
6.8
48
218
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
41.2
6.8
8
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.8
6.8
21
59
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.5
6.7
48
219
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
6.7
47
213
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.0
6.7
31
113
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
4.4
6.7
17
41
M01AH02
ATC
rofecoxib; oral
2.6
6.7
43
187
L04AA13
ATC
[U] leflunomide
7.2
6.6
15
22
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
7.2
6.6
15
22
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.6
6.6
42
181
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
6.5
6.6
16
26
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.7
6.6
37
150
R4110
NOMESCO Finland
Physiotherapy
2.1
6.5
85
499
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.3
6.5
17
42
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
5.8
6.4
17
31
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.0
6.4
92
558
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
9.6
6.4
12
13
C08CA01
ATC
amlodipine; oral
2.0
6.3
99
619
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
6.3
6
*
7108X
ICD-9 Finland
Diffuse diseases of connective tissue, Other specified diffuse diseases of connective tissue
+∞
6.3
6
*
1XC02, ,
NOMESCO Finland
27.5
6.3
8
*
N18.0
ICD-10 Finland
End-stage renal disease
27.5
6.3
8
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
6.2
116
770
A02BA02
ATC
ranitidine; systemic
2.2
6.2
60
312
WW500
NOMESCO Finland
Blood transfusion
4.3
6.2
16
39
I50.9
ICD-10 Finland
Heart failure, unspecified
2.8
6.2
33
130
SAA04
NOMESCO Finland
Special examination of mouth
3.7
6.2
20
58
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
6.1
109
712
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
4.1
6.1
17
44
N18.8
ICD-10 Finland
Other chronic renal failure
10.4
6.1
11
11
N02AA05
ATC
oxycodone; systemic
2.3
6.1
52
257
H11.3
ICD-10 Finland
Conjunctival haemorrhage
3.9
6.0
18
49
J01MA01
ATC
ofloxacin; systemic
3.0
6.0
28
102
D07AD01
ATC
clobetasol; topical
2.2
6.0
57
294

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
160
119
37.44
190.76
10.4
2.0
21.11
5.75
iu/ml
6.36
98
29
86
83
15.49
83.03
1.9
1.3
18.63
2.68
u/ml
0.76
27
12
86
83
15.49
83.03
2.0
1.4
11.08
7.47
u/ml
0.28
33
20
86
87
14.75
80.43
1.9
1.3
46.52
1.40
u/ml
—
16
6
78
105
10.47
58.41
1.9
1.3
0.90
2.04
u/ml
—
8
5
141
366
7.80
58.31
3.0
1.4
774.69
555.06
titre
1.00
98
89
63
71
11.63
53.56
1.8
1.3
51.99
50.80
u/ml
0.02
21
12
47
41
13.97
47.03
1.7
1.1
8.07
5.07
u/ml
0.39
28
15
40
27
17.54
46.16
2.9
2.0
—
—
—
0
0
38
24
18.58
45.30
1.7
1.3
—
—
—
0
0
39
26
17.68
45.26
1.8
1.3
—
—
—
0
0
178
732
6.35
40.55
17.2
6.0
—
—
—
0
0
213
1148
7.93
32.17
20.8
6.1
0.58
0.55
e9/l
1.17
203
995
213
1155
7.84
31.74
20.8
6.1
0.04
0.04
e9/l
0.41
203
999
213
1174
7.60
30.57
20.9
6.1
1.63
1.93
e9/l
2.84
207
1046
213
1197
7.31
29.20
21.4
6.2
0.15
0.18
e9/l
3.07
207
1055
73
184
5.24
28.46
7.7
4.3
0.44
0.87
%
0.81
32
50
68
180
4.86
24.72
8.5
4.3
0.00
0.21
%
1.74
28
43
214
1291
6.51
24.61
24.0
9.8
3.64
3.97
e9/l
1.76
206
1134
71
196
4.70
24.48
8.4
4.2
0.58
1.02
%
0.99
31
59
118
479
3.84
23.77
5.2
2.5
3.16
7.87
e6/l
2.05
109
441
191
1080
4.59
23.25
13.5
6.5
1.22
1.22
mmol/l
0.55
175
927
122
531
3.61
21.65
6.3
3.8
—
—
—
0
0
185
1057
4.14
21.34
4.3
2.6
81.53
78.20
nmol/l
0.92
179
960
65
186
4.41
21.16
8.9
4.7
0.04
0.16
%
0.37
23
43
102
401
3.66
21.10
7.3
2.5
495.75
505.00
mosm/kgh2o
0.18
92
352
199
1212
4.55
20.53
8.7
3.7
0.00
0.00
estimate
-0.00
49
242
142
701
3.47
20.23
8.0
3.1
14.10
125.87
e6/l
0.65
120
537
128
594
3.44
20.16
7.8
2.9
0.13
0.36
e6/l
1.75
104
425
198
1222
4.35
19.54
8.9
3.7
75.04
0.00
estimate
1.07
53
250
58
161
4.42
19.53
1.7
1.7
1.22
1.40
g/l
0.33
53
150
199
1238
4.35
19.28
8.9
3.8
0.09
0.00
estimate
0.49
47
230
171
970
3.57
18.98
7.2
3.4
6.28
6.16
ph
0.66
91
541
57
166
4.18
17.92
9.2
7.1
9.93
8.57
mmol/l
0.73
57
157
135
681
3.21
17.91
8.0
3.9
7.40
7.40
ph
0.01
109
473
168
964
3.41
17.84
8.8
4.2
34.66
36.45
g/l
4.13
162
916
152
824
3.26
17.76
10.6
3.8
64.89
74.68
e6/l
0.09
121
565
26
38
7.54
17.33
2.0
1.3
—
—
—
0
0
75
279
3.44
16.35
3.8
3.2
3.61
6.07
e9/l
1.10
67
251
47
128
4.31
16.06
1.8
2.3
—
—
—
0
0
113
540
3.04
16.06
4.2
2.2
2.71
2.98
mg/l
0.52
105
465
55
171
3.86
15.66
3.7
3.1
62.42
74.21
e9/l
1.50
39
128
66
240
3.40
14.77
2.3
2.2
346.20
385.18
nmol/l
0.76
61
229
126
663
2.87
14.67
6.7
2.8
0.40
0.18
—
5
11
60
208
3.50
14.45
6.4
4.0
7.37
7.39
ph
2.28
38
112
127
686
2.78
13.84
3.5
2.9
—
—
—
0
0
24
42
6.23
13.49
1.2
2.0
—
—
—
0
0
35
87
4.53
13.35
1.4
1.2
—
—
—
0
0
24
43
6.08
13.17
1.3
1.5
—
—
—
0
0
22
39
6.10
12.18
1.4
1.4
156.34
174.57
au/ml
—
7
13
72
312
2.86
11.65
3.0
2.0
—
—
—
0
0
74
328
2.81
11.45
7.4
2.9
1.88
3.32
e6/l
0.97
42
147
26
58
4.90
11.25
1.3
3.0
35.04
28.57
mg/l
0.50
21
52
156
1004
2.55
10.96
25.0
10.4
0.00
0.00
e9/l
0.09
140
818
25
58
4.69
10.32
1.4
3.0
41.74
130.78
mg/l
0.44
20
52
23
50
4.98
10.24
1.2
2.9
1.15
1.28
ratio
—
9
25
59
245
2.86
10.21
2.7
1.5
—
—
—
0
0
147
942
2.42
10.11
33.6
10.6
1.37
1.15
inr
3.65
132
757
118
692
2.37
9.87
8.1
3.9
18.09
9.65
mg/mmol
0.76
87
388
122
730
2.35
9.69
6.1
3.1
6.31
7.27
mmol/l
2.05
113
611
97
528
2.39
9.55
2.9
1.8
1.30
1.08
mg/l
0.36
84
415
103
577
2.36
9.48
13.3
4.7
—
—
—
0
0
12
5
25.12
9.00
1.4
2.0
—
—
—
0
0
15
12
13.23
8.99
2.0
2.3
32.27
206.17
e6/l
1.98
15
12
32
100
3.53
8.85
1.3
1.2
—
—
—
0
0
114
683
2.26
8.80
6.2
3.2
95.19
53.21
mg/l
0.89
80
405
20
31
6.93
8.38
2.6
3.7
0.70
1.94
%
1.25
20
26
22
55
4.30
8.26
2.7
2.6
6.36
2.15
index
0.42
11
33
43
168
2.89
8.23
14.0
7.7
—
—
—
0
0
110
673
2.16
7.83
7.9
3.9
0.00
0.00
estimate
-0.00
47
232
52
230
2.60
7.83
3.3
2.0
0.00
0.06
estimate
—
10
51
13
11
12.40
7.67
1.5
1.2
29.69
27.73
s
0.33
13
11
34
122
3.08
7.53
3.5
2.1
0.00
0.02
estimate
—
9
46
42
170
2.78
7.50
1.5
1.4
—
—
—
0
0
56
263
2.47
7.42
1.7
1.6
—
—
—
0
0
109
683
2.08
7.12
7.8
3.1
0.00
0.00
estimate
-0.00
45
193
13
13
10.49
7.12
1.5
1.2
—
—
—
0
0
25
77
3.50
7.05
3.6
4.0
0.78
0.91
%
0.86
25
72
68
356
2.26
7.01
1.7
1.6
—
—
—
0
0
72
388
2.22
6.91
6.9
3.5
323.21
139.69
ng/l
0.75
58
278
12
11
11.40
6.87
1.2
1.1
—
—
—
0
0
64
330
2.28
6.83
1.3
1.2
—
—
—
0
0
134
916
2.03
6.80
8.5
3.6
0.00
0.00
estimate
0.50
44
201
21
59
3.80
6.75
1.8
2.1
14.90
11.31
mg/l
1.22
21
59
19
50
4.04
6.67
1.3
1.5
—
—
—
0
0
73
401
2.17
6.66
2.0
2.0
—
—
—
0
0
56
276
2.34
6.62
9.0
5.8
105.48
103.79
mmol/l
2.27
56
276
26
86
3.27
6.57
3.4
3.7
1.69
1.62
%
0.12
26
81
9
5
18.61
6.31
2.0
2.0
2.22
9.80
%
—
9
5
154
1127
2.00
6.22
5.8
3.1
179.16
92.14
ug/l
2.11
147
1063
91
556
2.02
6.19
1.8
1.4
2.40
2.18
g/l
0.74
65
344
17
44
4.08
6.10
5.2
3.2
3.70
4.92
e9/l
1.71
17
44
162
1212
2.01
6.08
7.5
6.1
9.75
10.26
umol/l
0.31
157
1144
9
6
15.50
5.95
1.9
1.8
36.56
30.00
%
—
9
6
136
963
1.94
5.94
2.4
2.0
102.09
99.26
pmol/l
0.25
67
471
17
35
5.14
5.86
1.6
1.5
—
—
—
0
0
20
60
3.54
5.86
1.8
1.6
90.22
197.11
ug/l
1.51
20
55
39
173
2.49
5.77
7.7
2.6
0.10
0.15
e6/l
0.30
39
162
60
322
2.15
5.72
4.0
2.1
151.17
96.16
ug/g
0.84
53
253
13
20
6.80
5.64
1.1
1.3
—
—
—
0
0
46
224
2.30
5.54
9.2
6.6
7.45
7.42
ph
2.78
27
134
117
803
1.88
5.49
4.7
3.5
26.33
34.62
ng/l
0.44
88
505
21
68
3.29
5.49
1.3
1.5
—
—
—
0
0
14
25
5.87
5.46
1.2
1.6
—
—
—
0
0
60
328
2.10
5.43
1.6
1.7
1167.79
1255.80
nmol/l
0.38
51
250
9
8
11.62
5.33
1.9
1.3
—
—
—
0
0
104
702
1.84
5.03
3.2
2.3
—
—
—
0
0
19
62
3.24
4.91
5.5
3.0
62.16
61.69
%
0.05
19
62
16
47
3.57
4.83
1.3
1.2
—
—
—
0
0
24
91
2.82
4.82
6.1
3.6
—
—
—
0
0
55
305
2.04
4.75
1.8
1.4
—
—
—
0
0
12
22
5.68
4.66
1.7
1.7
—
—
—
0
0
12
22
5.68
4.66
1.7
1.7
—
—
—
0
0
12
22
5.68
4.66
1.7
1.7
—
—
—
0
0
12
22
5.68
4.66
1.7
1.7
—
—
—
0
0
7
5
14.35
4.60
1.1
1.6
—
—
—
0
0
139
1043
1.78
4.58
3.8
2.7
—
—
estimate
—
0
0
43
222
2.14
4.47
9.4
6.6
-0.41
1.04
mmol/l
0.90
37
188
99
682
1.76
4.33
14.7
6.6
—
—
—
0
0
20
73
2.90
4.30
4.8
2.8
198.90
280.85
mg/l
—
10
27
113
812
1.73
4.23
3.6
3.0
2.34
2.36
mmol/l
0.80
108
740
11
22
5.18
4.05
1.2
1.2
—
—
—
0
0
14
43
3.39
3.97
2.5
2.0
—
—
—
0
0
8
11
7.47
3.89
1.5
1.6
0.65
0.62
mmol/l
—
8
11
92
637
1.71
3.86
1.9
1.6
20.23
21.42
nmol/l
0.38
80
532
29
135
2.30
3.86
6.0
3.5
7.41
7.42
ph
0.73
23
108
16
55
3.04
3.81
8.7
2.4
66.75
57.31
%
0.98
16
55
39
206
2.06
3.81
1.2
1.2
—
—
—
0
0
7
8
8.96
3.79
1.1
1.5
—
—
—
0
0
10
21
4.92
3.59
3.7
4.5
—
—
—
0
0
73
482
1.74
3.59
1.4
1.4
10.75
9.12
u/ml
0.09
31
196
27
128
2.25
3.45
1.1
1.1
—
—
—
0
0
36
192
2.03
3.43
3.6
2.2
6.20
6.17
ph
0.05
20
124
13
40
3.37
3.19
2.2
1.4
—
—
—
0
0
9
20
4.63
3.14
2.0
1.8
0.59
0.58
e9/l
—
9
20
76
527
1.64
3.06
7.4
3.8
1.02
1.02
kg/l
0.26
62
332
86
616
1.61
3.04
1.4
1.3
0.67
1.52
u/ml
0.77
20
194
5
5
10.17
2.99
1.2
1.2
63.00
66.90
%
—
5
5
6
9
6.80
2.88
1.0
1.1
—
—
—
0
0
10
28
3.68
2.81
1.3
1.7
—
—
—
0
0
17
72
2.46
2.79
6.9
3.9
24.15
24.92
mmol/l
0.39
17
72
25
126
2.10
2.77
7.0
2.8
1.40
1.26
%
0.24
25
126
13
48
2.80
2.76
10.2
2.0
67.85
58.01
%
1.21
13
48
36
208
1.86
2.73
1.4
1.4
—
—
—
0
0
24
124
2.04
2.51
7.4
2.8
0.56
0.61
%
0.39
24
124
6
12
5.10
2.41
1.2
1.1
—
—
—
0
0
12
46
2.69
2.39
4.6
2.6
9.16
8.50
pmol/l
0.12
12
46
5
8
6.35
2.38
1.0
1.0
2267.00
1764.12
miu/ml
—
5
8
17
78
2.27
2.37
1.2
1.4
352.60
316.90
ug/g
—
10
47
9
28
3.30
2.33
1.4
1.4
—
—
—
0
0
9
28
3.30
2.33
1.4
1.4
3.36
3.04
g/l
—
9
23
9
28
3.30
2.33
1.4
1.4
0.75
0.44
g/l
—
9
23
9
28
3.30
2.33
1.4
1.4
7.84
6.39
g/l
—
9
23
24
128
1.97
2.31
7.2
7.1
23.76
24.92
mmol/l
0.69
24
128
6
13
4.70
2.28
1.2
1.2
—
—
—
0
0
5
10
5.08
2.08
2.8
1.5
38.40
65.07
ug/l
—
5
10
5
10
5.08
2.08
2.0
2.3
3093.00
844.30
mg
—
5
10
7
20
3.57
2.07
1.4
1.2
—
—
—
0
0
19
97
2.04
2.06
2.6
1.9
—
—
—
0
0
11
44
2.57
2.04
1.4
1.0
28.58
18.51
au/ml
—
5
16
10
39
2.63
1.96
1.6
1.1
—
—
—
0
0
5
11
4.62
1.95
1.0
1.2
—
—
—
0
0
7
22
3.24
1.89
1.1
1.3
—
—
—
0
0
8
28
2.92
1.88
3.1
2.1
—
—
—
0
0
18
94
1.99
1.85
2.1
2.4
—
—
—
0
0
22
125
1.84
1.79
12.4
8.0
0.58
0.64
%
0.29
22
125
116
963
1.39
1.77
2.4
2.1
—
—
—
0
0
76
955
0.70
1.76
3.2
3.2
—
—
—
0
0
10
43
2.38
1.61
10.5
3.8
—
—
—
0
0
12
57
2.16
1.58
2.4
2.7
7.40
7.42
ph
0.72
12
57
5
15
3.38
1.53
1.0
1.3
—
—
—
0
0
68
527
1.40
1.52
1.5
1.4
27.73
25.60
iu/ml
0.07
20
176
6
22
2.77
1.44
2.7
3.0
105.83
106.32
mmol/l
—
6
22
6
22
2.77
1.44
2.7
3.0
1.19
1.19
mmol/l
—
6
22
6
22
2.77
1.44
2.7
3.0
3.97
3.85
mmol/l
—
6
22
5
17
2.98
1.36
1.0
1.1
—
—
—
0
0
8
34
2.40
1.30
1.4
1.2
—
—
—
0
0
21
131
1.66
1.28
12.7
7.8
1.33
1.37
%
0.04
21
131
226
2157
1.68
1.26
42.9
14.2
17.38
20.86
mg/l
1.33
217
1744
34
240
1.48
1.25
1.6
4.1
18.99
9.82
ug/l
0.23
24
190
27
183
1.53
1.19
1.6
2.9
47.86
54.36
u/ml
0.13
27
177
6
26
2.34
1.19
1.2
1.0
—
—
—
0
0
6
26
2.34
1.19
3.0
2.0
12.18
10.77
%
—
6
26
11
57
1.97
1.19
1.8
2.4
—
—
—
0
0
37
271
1.43
1.14
1.7
1.3
—
—
—
0
0
7
32
2.22
1.09
1.1
1.0
—
—
—
0
0
5
22
2.30
1.04
1.0
1.5
—
—
—
0
0
9
52
1.76
0.93
1.0
1.1
—
—
—
0
0
9
52
1.76
0.93
1.0
1.1
—
—
—
0
0
32
238
1.40
0.92
1.5
1.5
—
—
—
0
0
6
29
2.10
0.90
1.2
3.2
—
—
—
0
0
216
2233
0.71
0.87
29.6
12.7
—
—
—
0
0
26
190
1.41
0.83
11.0
3.5
—
—
—
0
0
12
73
1.68
0.83
1.4
1.1
—
—
—
0
0
17
116
1.50
0.76
1.0
1.1
—
—
—
0
0
7
38
1.87
0.74
1.4
1.2
—
—
—
0
0
5
27
1.87
0.69
1.0
1.1
109.00
110.00
pmol/l
—
5
27
109
988
1.19
0.64
1.9
1.9
1.43
1.40
mmol/l
0.16
93
851
22
287
0.74
0.62
1.6
1.5
—
—
—
0
0
188
1794
1.21
0.58
5.8
4.9
14.79
14.60
pmol/l
0.53
180
1667
229
2332
0.69
0.58
58.5
22.2
30.20
30.24
pg
0.12
229
2314
10
65
1.56
0.56
6.8
5.3
1.18
1.22
mmol/l
—
10
59
12
170
0.69
0.55
1.8
2.7
0.89
0.80
ug/l
—
5
102
204
2106
0.80
0.55
5.2
4.9
5.48
5.84
mmol/l
4.30
197
1962
229
2331
0.69
0.55
58.6
22.2
91.68
91.09
fl
1.06
229
2313
6
38
1.59
0.54
2.2
2.2
5.12
4.97
kpa
—
6
38
6
38
1.59
0.54
2.2
2.2
7.70
8.72
kpa
—
6
38
6
39
1.55
0.53
1.2
1.1
—
—
—
0
0
13
178
0.72
0.50
1.4
1.3
—
—
—
0
0
20
254
0.77
0.48
1.3
1.3
—
—
—
0
0
214
2193
0.80
0.48
6.4
5.8
2.55
2.80
mmol/l
4.45
207
2054
191
1838
1.18
0.47
50.4
17.8
14.19
13.54
%
7.86
191
1825
56
632
0.85
0.45
1.5
1.5
—
—
—
0
0
5
32
1.57
0.42
5.2
2.1
36.20
33.16
pg
—
5
32
0
16
0.00
0.41
0.0
15.5
—
876.69
—
0
16
0
17
0.00
0.41
0.0
12.8
—
0.71
—
0
17
0
18
0.00
0.40
0.0
1.1
—
356.36
—
0
11
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
6
41
1.47
0.36
3.0
2.8
—
—
—
0
0
35
303
1.18
0.35
1.4
1.3
—
—
—
0
0
180
1857
0.88
0.34
50.1
18.5
328.96
331.35
g/l
3.11
180
1852
17
137
1.26
0.33
1.2
1.2
—
—
—
0
0
223
2190
1.22
0.32
37.3
16.0
139.43
139.82
mmol/l
1.49
223
2148
223
2194
1.20
0.28
38.1
16.1
3.94
3.94
mmol/l
0.04
223
2146
24
207
1.18
0.26
1.6
1.7
—
—
—
0
0
213
2166
0.87
0.26
5.9
5.2
4.48
4.81
mmol/l
5.16
206
2031
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
0.00
—
0
12
0
13
0.00
0.21
0.0
2.5
—
145.38
—
0
13
7
58
1.21
0.18
3.1
4.4
3.80
3.84
mmol/l
—
7
58
5
70
0.71
0.17
53.4
6.7
—
—
—
0
0
8
68
1.18
0.17
1.4
1.9
—
—
—
0
0
213
2156
0.90
0.16
5.8
5.1
1.45
1.54
mmol/l
2.49
207
2014
209
2072
1.06
0.08
6.8
5.9
1.99
1.86
mu/l
0.78
201
1944
229
2276
1.11
0.08
46.3
18.2
79.10
71.47
umol/l
1.26
229
2251
10
88
1.14
0.08
1.1
1.1
0.93
0.90
g/l
—
10
88
11
98
1.13
0.08
4.8
4.8
36.95
36.97
°c
0.10
11
98
9
84
1.07
0.07
1.0
1.1
1.53
1.60
g/l
—
9
84
229
2278
1.09
0.06
31.3
11.8
25.79
24.76
u/l
0.44
229
2229
28
268
1.05
0.05
3.2
5.1
0.85
2.00
ug/l
2.90
21
244
26
249
1.05
0.04
1.7
1.8
—
—
—
0
0
14
141
0.99
0.00
1.4
1.1
—
—
—
0
0
206
2055
1.02
0.00
5.0
4.3
1.28
1.29
mmol/l
0.07
201
1908
20
196
1.02
0.00
1.5
1.2
124.23
140.72
u/ml
—
6
86
8
87
0.92
0.00
1.4
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
1.83
—
0
5
8
81
0.99
0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
8
81
0.99
0.00
1.4
1.1
—
—
—
0
0
8
87
0.92
0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
8
87
0.92
0.00
1.4
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
10.97
—
0
6
7
71
0.99
-0.00
1.4
1.3
—
—
—
0
0
5
54
0.92
-0.00
1.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
65
0.92
-0.00
1.0
1.1
—
—
—
0
0
8
89
0.90
-0.00
1.5
1.3
—
—
—
0
0
6
63
0.95
-0.00
1.8
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
1.20
—
0
7
0
7
0.00
-0.00
0.0
1.7
—
15.04
—
0
7

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT and mortality.

Females

Parameter HR [95% CI] p-value
DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT 2.507 [2.07, 3.04] < 0.001
Birth year 0.993 [0.99, 1.0] 0.127

During the follow-up period (1.1.1998 — 31.12.2019), 239 out of 944 females with DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT died.

Males

Parameter HR [95% CI] p-value
DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT 1.985 [1.37, 2.88] < 0.001
Birth year 0.991 [0.98, 1.0] 0.061

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 199 males with DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT.

N-year risk Females Males
1 0.361% 0.465%
5 1.382% 2.756%
10 3.588% 6.675%
15 6.665% 12.351%
20 11.246% 20.503%

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT – Drug-induced systemic lupus erythematosus

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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