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Pervasive developmental disorders excl. Autism + Asperger

DOID EFO Endpoint Browser PheWeb

F5_PERVASIVE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F84
  • Hospital discharge: ICD-9 — 2998|2999B
  • Hospital discharge: excluded ICD-10 — F84.0, F84.1, F84.5
  • Cause of death: ICD-10 — F84
  • Cause of death: ICD-9 — 2998|2999B
  • Cause of death: excluded ICD-10 — F84.0, F84.1, F84.5

2 out of 7 registries used, show all original rules.

584

4. Check minimum number of events

None

584

5. Include endpoints

None

584

6. Filter based on genotype QC (FinnGen only)

491

Control definitions (FinnGen only)

Control exclude
F5_PSYCHDEV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F80-F89
Name in latin
Perturbationes formationales pervasivae (in pueritia)

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13185 3541 9638
Only index persons 10180 2894 7286
Unadjusted period prevalence (%)
Whole population 0.22 0.10 0.27
Only index persons 0.23 0.11 0.28
Median age at first event (years)
Whole population 8.61 10.02 8.07
Only index persons 10.22 11.89 9.55

-FinnGen-

Key figures

All Female Male
Number of individuals 491 219 272
Unadjusted period prevalence (%) 0.10 0.08 0.12
Median age at first event (years) 14.50 17.75 11.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
548
Matched controls
5407
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
2223.1
307.7
344
*
F84.8
ICD-10 Finland
Other pervasive developmental disorders
+∞
296.6
258
*
N05AX08
ATC
risperidone; systemic
14.3
162.9
174
170
F84.5
ICD-10 Finland
Asperger syndrome
244.6
160.8
159
9
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
14.9
151.6
154
138
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
26.6
118.2
85
37
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
9.6
113.4
159
220
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
9.4
112.2
161
229
F83
ICD-10 Finland
Mixed specific developmental disorders
650.2
111.6
107
*
IGV01
NOMESCO Finland
Psychiatric network contact
15.0
108.3
104
83
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
11.0
108.1
132
152
Z2445
NOMESCO Finland
Psychologist
8.8
107.0
163
248
N05AX12
ATC
aripiprazole; systemic
10.2
105.1
136
169
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
10.4
98.5
124
148
ZY010
NOMESCO Finland
Hospital outpatient
7.9
97.4
165
281
F29
ICD-10 Finland
Unspecified nonorganic psychosis
10.3
92.6
116
137
XA800
NOMESCO Finland
Neuropsychological investigation
10.8
88.8
106
117
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
7.6
88.5
150
254
N06BA04
ATC
methylphenidate; oral
6.6
88.2
184
385
F90.0
ICD-10 Finland
Disturbance of activity and attention
6.3
88.0
197
441
IGY99
NOMESCO Finland
Other psychiatric treatment contact
8.6
84.9
125
180
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
5.6
81.2
222
590
IGP01
NOMESCO Finland
Psychiatric family contact
10.0
80.8
102
121
IEV99
NOMESCO Finland
Other psychiatric network intervention
15.9
79.5
72
51
Z2446
NOMESCO Finland
Social worker
6.0
78.3
181
413
N05AH04
ATC
quetiapine; oral
5.3
76.5
224
627
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
7.2
76.4
134
233
R62.0
ICD-10 Finland
Delayed milestone
13.2
73.4
74
63
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
5.7
70.7
166
381
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
9.8
70.5
89
105
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
12.8
69.2
71
62
N05AH03
ATC
olanzapine; systemic
7.0
69.1
123
216
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
9.3
64.8
85
105
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
10.2
63.9
77
85
ICB06, ,
NOMESCO Finland
13.1
63.6
64
54
IGY02
NOMESCO Finland
Psychiatric monitoring contact
6.1
63.5
132
269
F84.0
ICD-10 Finland
Childhood autism
+∞
63.5
60
*
N06AB03
ATC
fluoxetine; oral
6.1
63.3
131
266
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
14.3
63.1
60
46
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
7.2
62.3
104
170
P85
ICPC
Mental retardation
22.0
61.6
47
23
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
11.1
57.7
65
65
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
6.9
55.4
95
159
N03AG01
ATC
valproic acid; systemic, rectal
6.9
54.9
94
157
ZYC01
NOMESCO Finland
Remote contact by phone
6.4
54.5
103
190
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
11.7
54.0
58
54
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
5.4
52.8
122
271
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
5.5
52.8
120
263
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
6.2
52.1
100
187
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
6.3
50.0
94
172
R5599
NOMESCO Finland
Other rehabilitation service
10.3
47.8
56
59
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
5.7
47.6
101
207
IAZ98
NOMESCO Finland
Other internal psychiatric consultation
16.1
46.6
41
27
N06AB06
ATC
sertraline; oral
4.4
46.5
144
404
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.1
46.4
165
513
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
11.5
46.1
50
47
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
9.8
45.1
55
61
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
15.7
44.8
40
27
F80.9
ICD-10 Finland
Developmental disorder of speech and language, unspecified
241.3
44.4
45
*
ZXY80
NOMESCO Finland
Doctor in multidisciplinary team
16.7
44.1
38
24
Z3226
NOMESCO Finland
Physiotherapist
3.8
44.0
182
626
F93.89
ICD-10 Finland
Other childhood emotional disorders
7.9
42.5
62
86
F82
ICD-10 Finland
Specific developmental disorder of motor function
84.5
42.4
47
6
IEP99
NOMESCO Finland
Other psychiatric family intervention
8.9
42.0
55
67
F88
ICD-10 Finland
Other disorders of psychological development
82.5
41.3
46
6
N05BA01
ATC
diazepam; systemic, rectal
5.4
41.0
91
193
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
7.1
40.7
66
103
N03AX09
ATC
lamotrigine; oral
5.9
40.6
80
152
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
12.8
40.0
40
33
IEP03
NOMESCO Finland
Focused parental counselling
7.9
39.9
58
80
IER01
NOMESCO Finland
Psychoeducation, group
11.7
39.6
42
38
F80.2
ICD-10 Finland
Receptive language disorder
112.0
39.1
42
*
Z2221
NOMESCO Finland
Medical doctor
3.3
37.7
205
828
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.9
37.4
93
217
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
7.4
37.4
57
83
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
15.7
37.1
33
22
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
5.5
36.9
78
158
F99
ICD-10 Finland
Mental disorder, not otherwise specified
7.9
36.0
52
71
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
5.3
35.8
79
166
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.4
35.5
171
638
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
10.3
35.5
41
42
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
5.8
35.4
70
133
Z3231
NOMESCO Finland
Registered nurse
3.0
34.9
246
1144
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
5.3
34.6
76
159
P99
ICPC
Psychological disorders other
6.6
34.5
59
97
N05AD01
ATC
haloperidol; systemic
13.9
33.7
32
24
F20.9
ICD-10 Finland
Schizophrenia, unspecified
10.3
33.7
39
40
Z50.5
ICD-10 Finland
Speech therapy
6.2
33.5
61
107
N06AB04
ATC
citalopram; systemic
4.2
32.8
100
273
N06AX16
ATC
venlafaxine; oral
3.9
32.6
115
348
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.4
31.7
68
139
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.4
31.6
90
233
F89
ICD-10 Finland
Unspecified disorder of psychological development
63.2
31.3
36
6
N06AX12
ATC
bupropion; oral
4.1
31.2
98
273
N05BA06
ATC
lorazepam; systemic, sublingual
8.9
30.4
39
46
P29
ICPC
Psychological sympt/compl other
3.4
30.3
136
481
SPAT1389
SPAT
Visit based on need for special support
3.7
30.0
110
341
R4120
NOMESCO Finland
Occupational therapy
5.0
29.5
69
152
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.4
29.4
83
213
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.4
29.1
61
122
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
11.6
27.3
29
26
R4130
NOMESCO Finland
Speech therapy
7.0
27.1
43
65
F80.1
ICD-10 Finland
Expressive language disorder
78.3
26.9
30
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.3
26.0
46
78
N06BA12
ATC
lisdexamfetamine; oral
5.7
25.9
51
96
N05AH02
ATC
clozapine; systemic
7.8
25.7
37
50
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.3
25.7
72
183
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
6.7
25.5
42
66
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
10.7
25.1
28
27
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
5.2
24.9
54
111
IAB03
NOMESCO Finland
Neuropsychiatric consultation
93.3
24.7
27
*
ZY000
NOMESCO Finland
Hospital inpatient
7.1
24.5
38
56
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
7.5
24.5
36
50
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
8.9
24.3
31
36
F80.8
ICD-10 Finland
Other developmental disorders of speech and language
69.8
23.9
27
*
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
8.9
23.5
30
35
IEY01
NOMESCO Finland
Psychoeducation, individual
8.6
23.0
30
36
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.4
22.8
93
306
IBB01
NOMESCO Finland
Psychiatric functioning capacity evaluation
22.3
22.2
32
15
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
39.9
21.8
27
7
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.9
21.6
68
188
F61.0
ICD-10 Finland
Mixed personality disorders
9.0
21.4
27
31
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
7.1
20.7
32
47
N05AB03
ATC
perphenazine; systemic, rectal
6.9
20.3
32
48
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.5
20.0
52
124
N05BA04
ATC
oxazepam; oral
2.7
19.9
132
569
F81.3
ICD-10 Finland
Mixed disorder of scholastic skills
59.1
19.9
23
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
6.5
19.6
33
53
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.3
19.5
84
285
N03AX11
ATC
topiramate; oral
6.1
19.0
34
58
IAB01
NOMESCO Finland
Psychiatric pharmacotherapy consultation
7.7
18.9
27
36
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
71.5
18.7
21
*
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.1
18.7
41
85
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
6.7
18.6
30
46
N05BA09
ATC
clobazam; oral
7.9
18.5
26
34
OAB43, ,
SPAT
0.3
18.4
68
1659
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
4.5
18.3
46
107
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
7.3
18.1
27
38
F81.8
ICD-10 Finland
Other developmental disorders of scholastic skills
68.1
17.7
20
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.7
17.6
116
496
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
5.4
17.4
35
67
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
21.5
17.3
25
12
N05AA02
ATC
levomepromazine; systemic
6.1
17.3
31
53
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.9
17.1
94
366
N03AF02
ATC
oxcarbazepine; oral
4.7
17.0
41
92
N06AX22
ATC
agomelatine; oral
5.9
17.0
31
54
IER05
NOMESCO Finland
Rehabilitative psychiatric group intervention, social skills
26.2
16.9
23
9
ZXY83
NOMESCO Finland
Social worker in multidisciplinary team
19.8
16.9
25
13
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
6.8
16.9
27
41
RS140, ,
NOMESCO Finland
22.4
16.9
24
11
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
16.7
128
588
F34.1
ICD-10 Finland
Dysthymia
4.6
16.3
40
91
IEP01
NOMESCO Finland
Psychoeducation, family
7.0
15.5
24
35
F60.9
ICD-10 Finland
Personality disorder, unspecified
12.7
15.4
27
22
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
4.9
15.3
35
75
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
11.6
15.3
28
25
F41.8
ICD-10 Finland
Other specified anxiety disorders
3.7
15.2
50
142
N05AN01
ATC
lithium; oral
5.2
15.1
32
64
F39
ICD-10 Finland
Unspecified mood [affective] disorder
5.0
15.1
33
68
N06AB10
ATC
escitalopram; oral
2.3
15.0
142
714
ZXY81
NOMESCO Finland
Psychologist in multidisciplinary team
12.8
14.9
26
21
N05AF03
ATC
chlorprothixene; systemic
6.4
14.9
25
40
SPAT1234
SPAT
Support of social functional capacity
5.9
14.8
27
47
N06AX26
ATC
vortioxetine; oral
2.9
14.7
75
279
N06BA09
ATC
atomoxetine; oral
6.9
14.7
23
34
ZXY01
NOMESCO Finland
Chief Physician, Head of Department or Deputy Chief Physician
12.2
14.6
26
22
RT150, ,
NOMESCO Finland
12.2
14.6
26
22
F84.4
ICD-10 Finland
Overactive disorder associated with mental retardation and stereotyped movements
+∞
14.6
14
*
P22
ICPC
Child behaviour symptom/complaint
3.2
14.3
59
194
F40.1
ICD-10 Finland
Social phobias
3.5
14.3
52
158
N03AE01
ATC
clonazepam; systemic
5.0
14.2
31
64
N03AX14
ATC
levetiracetam; systemic
5.1
13.9
30
61
RT420, ,
NOMESCO Finland
24.2
13.8
19
8
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.8
13.6
73
279
F84.2
ICD-10 Finland
Rett syndrome
+∞
13.5
13
*
SPAT1307
SPAT
Psychosocial counselling and guidance
2.5
13.5
94
410
Z07
ICPC
Education problem
4.7
13.4
32
71
N06AX21
ATC
duloxetine; oral
3.1
13.4
59
202
N05BE01
ATC
buspirone; oral
5.3
13.3
27
52
Z3229
NOMESCO Finland
Other healthcare associate professional
2.8
13.3
70
265
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
10.7
13.2
25
24
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
11.2
13.0
24
22
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.5
13.0
47
142
Z71.8
ICD-10 Finland
Other specified counselling
2.0
13.0
235
1495
RT490, ,
NOMESCO Finland
19.4
12.9
19
10
ZXY60
NOMESCO Finland
2-person team, nurses
10.7
12.7
24
23
A06AC01
ATC
ispaghula (psylla seeds); oral
2.7
12.6
76
308
A28
ICPC
Limited function/disability NOS
3.1
12.6
54
182
F81.0
ICD-10 Finland
Specific reading disorder
17.6
12.5
19
11
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
24.7
12.4
17
7
IEZ99
NOMESCO Finland
Other psychiatric rehabilitation intervention
14.6
12.3
20
14
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
14.6
12.3
20
14
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
9.2
12.2
25
28
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
38.0
12.2
15
*
ZXY03
NOMESCO Finland
Occupational therapist
12.6
12.1
21
17
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
18.3
12.0
18
10
N05CD08
ATC
midazolam; nasal, systemic
4.2
12.0
32
78
OAA43, ,
SPAT
2.8
12.0
64
244
K59.09
ICD-10 Finland
Constipation, unspecified
3.1
11.9
52
177
RS312, ,
NOMESCO Finland
47.1
11.9
14
*
F64.9
ICD-10 Finland
Gender identity disorder, unspecified
11.9
11.8
21
18
P27
ICPC
Fear of mental disorder
4.5
11.8
29
66
IBB03
NOMESCO Finland
Assessment of vocational rehabilitation needs in a mental health context
14.9
11.8
19
13
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.0
11.4
52
181
DFF20
NOMESCO Finland
Audiometry for children
5.1
11.4
24
48
P72
ICPC
Schizophrenia
5.8
11.3
21
37
N05AE04
ATC
ziprasidone; systemic
12.9
11.1
19
15
SPAT1240
SPAT
Therapeutic discussion
2.3
11.0
94
447
183
Kela drug reimbursment
Lamotrigin and topiramate
8.7
11.0
23
27
Z31.5
ICD-10 Finland
Genetic counselling
2.8
10.9
57
214
N06AB05
ATC
paroxetine; oral
4.0
10.9
31
79
F33.8
ICD-10 Finland
Other recurrent depressive disorders
10.7
10.8
20
19
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
18.0
10.7
16
9
N06AX03
ATC
mianserin; oral
5.2
10.7
22
43
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
3.5
10.6
37
109
ZYY79
NOMESCO Finland
Other indirect service without contact with patient
13.1
10.6
18
14
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.1
10.5
112
582
P74
ICPC
Anxiety disorder/anxiety state
2.6
10.5
63
255
ZXY57
NOMESCO Finland
2-person team, nurse-social worker
14.4
10.5
17
12
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
110.6
10.4
11
*
2998A
ICD-9 Finland
Psychoses with origin specific to childhood, Other specified early childhood psychoses[LAPSUUDEN LAAJA-ALAIN KEHITYSHÄIR,TÄYDEL OIREYHTYMÄ]
+∞
10.4
10
*
RL720, ,
NOMESCO Finland
+∞
10.4
10
*
3159X
ICD-9 Finland
Specific delays in development, Unspecified delay in development
+∞
10.4
10
*
ICZ04
NOMESCO Finland
Preparation of psychiatric treatment plan
12.2
10.3
18
15
RL140, ,
NOMESCO Finland
12.2
10.3
18
15
IBB02
NOMESCO Finland
Psychiatric evaluation of working capacity and rehabilitation
8.3
10.3
22
27
SPAT1396
SPAT
Meeting with multidisciplinary group of experts
4.0
10.3
30
78
N06AA04
ATC
clomipramine; systemic
10.7
10.3
19
18
ZXY56
NOMESCO Finland
2-person team, nurse-psychologist
10.7
10.3
19
18
T07
ICPC
Weight gain
4.5
10.2
25
57
F32.8
ICD-10 Finland
Other depressive episodes
5.0
10.1
22
45
IEP02
NOMESCO Finland
Child-centred family therapy
3.7
10.1
33
93
F94.9
ICD-10 Finland
Childhood disorder of social functioning, unspecified
40.3
9.9
12
*
N06AX11
ATC
mirtazapine; oral
2.0
9.9
139
798
RS220, ,
NOMESCO Finland
4.7
9.9
23
50
ZXY52
NOMESCO Finland
2-person team, doctor-psychologist
12.3
9.8
17
14
R1260
NOMESCO Finland
Evaluation of communicative skills
8.2
9.8
21
26
F81.9
ICD-10 Finland
Developmental disorder of scholastic skills, unspecified
20.2
9.8
14
7
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
3.5
9.7
33
96
H50.30
ICD-10 Finland
Intermittent esotropy
5.0
9.7
21
43
XA820, ,
NOMESCO Finland
13.5
9.6
16
12
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
9.2
9.5
19
21
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
4.1
9.4
26
65
R1250
NOMESCO Finland
Evaluation of functional capability
7.6
9.4
21
28
ZYB05
NOMESCO Finland
Outreach service at patient’s workplace, school or occupational/school health care
17.7
9.4
14
8
F84.3
ICD-10 Finland
Other childhood disintegrative disorder
+∞
9.4
9
*
F84.11
ICD-10 Finland
Autism with atypical symptoms
+∞
9.4
9
*
3153A
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[KIELENKEHITYKSEN ERITYISVAIKEUS]
+∞
9.4
9
*
RL130, ,
NOMESCO Finland
12.5
9.3
16
13
F21
ICD-10 Finland
Schizotypal disorder
21.8
9.3
13
6
ZYY01
NOMESCO Finland
Contact between professionals
9.6
9.2
18
19
R5140
NOMESCO Finland
Monitoring the use of the aid
3.4
9.2
33
99
N03AX16
ATC
[U] pregabalin
2.5
9.2
62
265
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.8
9.2
46
169
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.9
9.1
140
827
ZXY49
NOMESCO Finland
Other health care provider
8.4
9.0
19
23
IBZ08
NOMESCO Finland
Gender identity assessment
11.6
9.0
16
14
Z61.8
ICD-10 Finland
Other negative life events in childhood
11.6
9.0
16
14
G40.89
ICD-10 Finland
Other epilepsy
15.7
9.0
14
9
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.2
8.8
76
362
RT160, ,
NOMESCO Finland
8.7
8.8
18
21
F43.1
ICD-10 Finland
Post-traumatic stress disorder
3.2
8.8
36
118
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.7
8.7
28
78
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.8
8.7
44
163
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
50.1
8.6
10
*
N03AF01
ATC
carbamazepine; oral, rectal
6.7
8.6
21
32
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
6.7
8.6
21
32
N05AE05
ATC
lurasidone; oral
11.7
8.5
15
13
P24
ICPC
Specific learning problem
3.1
8.5
36
120
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
16.4
8.5
13
8
F90.1
ICD-10 Finland
Hyperkinetic conduct disorder
27.6
8.5
11
*
ZXY54
NOMESCO Finland
2-person team, doctor-occupational therapist
90.2
8.4
9
*
F91.3
ICD-10 Finland
Oppositional defiant disorder
12.8
8.3
14
11
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.9
8.3
24
62
3153X
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[PUHEEN KEHITYKSEN ERITYISVAIKEUS]
+∞
8.3
8
*
T82
ICPC
Obesity
3.5
8.3
28
81
ZXY61
NOMESCO Finland
2-person team, special workers
10.8
8.3
15
14
D12
ICPC
Constipation
3.8
8.3
25
67
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
9.5
8.2
16
17
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
4.7
8.2
19
41
K03.66
ICD-10 Finland
Tooth plaque
2.0
8.2
94
500
R4110
NOMESCO Finland
Physiotherapy
1.8
8.2
137
828
F42.1
ICD-10 Finland
Predominantly compulsive acts [obsessional rituals]
6.6
8.2
20
31
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
7.6
8.1
18
24
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
8.1
107
599
ZYA02
NOMESCO Finland
Contact at day ward in specialised medical care or in other intensive outpatient care setting
33.4
8.0
10
*
P06
ICPC
Sleep disturbance
2.1
8.0
84
432
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.1
8.0
34
114
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.9
7.9
37
131
OAB95, ,
SPAT
0.2
7.9
8
373
RS214, ,
NOMESCO Finland
13.1
7.8
13
10
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
7.8
150
943
P01
ICPC
Feeling anxious/nervous/tense
1.8
7.8
158
1010
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
10.9
7.8
14
13
P03
ICPC
Feeling depressed
1.9
7.7
108
615
F94.8
ICD-10 Finland
Other childhood disorders of social functioning
45.0
7.7
9
*
IAB11
NOMESCO Finland
Psychiatric mood consultation
45.0
7.7
9
*
F84
ICD-10 Finland
Pervasive developmental disorders
45.0
7.7
9
*
ZXY85
NOMESCO Finland
Other special worker in multidisciplinary team
45.0
7.7
9
*
Z63.5
ICD-10 Finland
Disruption of family by separation and divorce
7.5
7.6
17
23
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.5
7.6
26
76
SPAT1229
SPAT
Assessment of need for aid
4.4
7.6
19
44
Z72.8
ICD-10 Finland
Other problems related to lifestyle
8.1
7.6
16
20
IAB13
NOMESCO Finland
Psychiatric sleep disorder consultation
25.1
7.5
10
*
R4170
NOMESCO Finland
Therapy forms involving educational rehabilitation
25.1
7.5
10
*
IER02, ,
SPAT
25.1
7.5
10
*
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
25.1
7.5
10
*
SPAT1298
SPAT
Other function in accordance with nutritional therapy nomenclature
10.1
7.5
14
14
N04AA02
ATC
biperiden; systemic
10.1
7.5
14
14
E66.00
ICD-10 Finland
Metabolic syndrome
3.7
7.5
24
67
OAA80, ,
SPAT
0.2
7.5
10
467
C07AA05
ATC
propranolol; systemic
1.9
7.4
103
585
ZXE00
NOMESCO Finland
One hour or less
1.7
7.4
203
1406
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.7
7.3
40
154
P28
ICPC
Limited function/disability (P)
8.4
7.3
15
18
R4140
NOMESCO Finland
Psychotherapy
8.4
7.3
15
18
F84.10
ICD-10 Finland
Autism in atypical age
+∞
7.3
7
*
2999A
ICD-9 Finland
Psychoses with origin specific to childhood, Unspecified[LAPSUUDEN LAAJA-AL.KEHITYSHÄIR,NUD,TÄYDEL OIREYHTYM]
+∞
7.3
7
*
RT190, ,
NOMESCO Finland
10.9
7.3
13
12
F20.8
ICD-10 Finland
Other schizophrenia
15.8
7.2
11
7
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
7.1
122
739
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.5
7.1
47
199
ZXY58
NOMESCO Finland
2-person team, nurse-occupational therapist
20.1
7.1
10
5
Z03
ICPC
Housing/neighbourhood problem
20.1
7.1
10
5
ZXY84
NOMESCO Finland
Occupational therapist in multidisciplinary team
20.1
7.1
10
5
C02AC02
ATC
guanfacine; oral
20.1
7.1
10
5
F90.8
ICD-10 Finland
Other hyperkinetic disorders
12.1
7.0
12
10
F41.1
ICD-10 Finland
Generalized anxiety disorder
2.2
7.0
61
291
F92.0
ICD-10 Finland
Depressive conduct disorder
10.1
7.0
13
13
F42
ICD-10 Finland
Obsessive-compulsive disorder
10.1
7.0
13
13
WYA30, ,
SPAT
7.0
7.0
16
23
IAB07
NOMESCO Finland
Consultation concerning a patient with self-harm intention
7.6
6.9
15
20
H60.9
ICD-10 Finland
Otitis externa, unspecified
2.2
6.8
59
281
F32
ICD-10 Finland
Depressive episode
2.6
6.8
40
160
N05AX15
ATC
cariprazine; oral
8.3
6.8
14
17
IBZ07
NOMESCO Finland
Neurological assessment in psychiatry
40.0
6.7
8
*
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
4.1
6.7
18
44
N05AF05
ATC
zuclopenthixol; systemic
16.7
6.7
10
6
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.3
6.7
53
244
H53.0
ICD-10 Finland
Amblyopia ex anopsia
3.5
6.6
22
63
G47.3
ICD-10 Finland
Sleep apnoea
2.1
6.6
62
305
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
3.3
6.6
24
73
R53
ICD-10 Finland
Malaise and fatigue
1.8
6.6
125
779
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
5.9
6.6
17
29
Z13.88
ICD-10 Finland
Special screening examination for other specified diseases and disorders
2.0
6.6
80
434
RT130, ,
NOMESCO Finland
12.3
6.5
11
9
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.7
6.5
34
128
IEY06
NOMESCO Finland
Psychiatric treatment and rehabilitation coaching
8.7
6.5
13
15
ICC03
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric ward
10.1
6.5
12
12
P76
ICPC
Depressive disorder
2.2
6.5
59
287
SPAT1365
SPAT
Health check-up performed during first study year due to special need in students of upper secondary schools or vocational schools
6.9
6.5
15
22
C07AB07
ATC
bisoprolol; oral
1.9
6.4
86
481
Z29
ICPC
Social problem NOS
3.1
6.4
27
90
R4110, ,
SPAT
2.3
6.4
47
209
SPAT1243
SPAT
Psychiatric/psychological examination
2.7
6.3
34
130
IBC98
NOMESCO Finland
Other child protection assessment
6.6
6.3
15
23
A04
ICPC
Weakness/tiredness general
1.8
6.3
105
631
AA1AD
NOMESCO Finland
CT of head and brain
2.0
6.2
72
383
ZXY59
NOMESCO Finland
2-person team, nurse-other special worker
18.0
6.2
9
5
OAB48, ,
SPAT
0.4
6.2
30
698
ZYB06
NOMESCO Finland
Outreach service in patient's nursery
+∞
6.2
6
*
2999B
ICD-9 Finland
Psychoses with origin specific to childhood, Unspecified[LAPSUUDEN LAAJA-ALAINEN KEHITYSHÄIRIÖ NUD,JÄLKITILA]
+∞
6.2
6
*
F93.2
ICD-10 Finland
Social anxiety disorder of childhood
+∞
6.2
6
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
6.2
122
767
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.2
6.2
24
76
L28
ICPC
Limited function/disability (L)
2.3
6.2
49
225
F60.1
ICD-10 Finland
Schizoid personality disorder
26.6
6.2
8
*
N05AE03
ATC
sertindole; oral
26.6
6.2
8
*
A06AD11
ATC
lactulose; oral
2.5
6.2
39
162
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
6.3
6.1
15
24
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
6.1
112
691
F41.09
ICD-10 Finland
UNS Panic Syndrome
2.7
6.0
31
116
IAB08
NOMESCO Finland
Consultation concerning a patient who has attempted suicide
10.0
6.0
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
54
82
7.10
34.04
6.4
6.3
405.27
410.91
umol/l
0.08
48
76
314
1765
2.77
29.83
6.4
12.5
1.23
1.23
mmol/l
0.27
302
1686
329
1902
2.77
29.43
6.5
11.7
1.23
1.22
mmol/l
0.28
304
1752
36
44
8.57
27.21
22.1
30.5
1385.78
1422.30
nmol/l
0.06
36
44
219
1079
2.67
26.25
2.2
1.7
100.92
97.18
pmol/l
0.69
126
577
92
294
3.51
23.67
2.0
1.7
436.60
308.40
mu/l
2.13
84
273
448
3240
3.00
22.74
5.5
3.8
14.38
14.53
pmol/l
0.68
429
2997
294
1750
2.42
22.61
3.1
3.5
66.88
67.51
nmol/l
0.16
276
1666
81
246
3.64
22.47
1.6
1.6
884.18
1066.89
nmol/l
1.18
59
193
178
847
2.59
22.28
3.4
4.5
7.39
7.39
ph
0.09
117
582
90
301
3.33
21.46
5.1
2.9
—
—
—
0
0
200
1034
2.43
20.70
2.8
3.0
2.38
2.39
mmol/l
0.42
187
960
485
3733
3.45
20.69
6.6
4.4
1.92
1.87
mu/l
0.57
472
3545
148
667
2.63
20.50
1.9
1.4
17.26
19.78
nmol/l
1.61
136
596
502
4016
3.78
18.58
14.7
12.6
3.88
3.93
mmol/l
4.23
493
3904
502
4018
3.77
18.52
14.7
12.6
139.78
139.48
mmol/l
3.09
495
3925
157
761
2.45
18.42
3.5
2.9
226.55
383.28
u/l
0.78
148
744
225
1333
2.13
15.89
4.6
4.2
28.83
31.88
u/l
1.47
214
1272
301
2020
2.04
14.87
3.9
2.5
—
—
—
0
0
404
3028
2.20
14.74
5.1
2.8
5.71
5.50
mmol/l
2.05
388
2811
360
2592
2.08
14.47
6.5
6.5
104.19
102.45
u/l
0.15
344
2457
322
2265
1.98
13.35
5.6
7.2
6.06
6.18
mmol/l
0.42
303
2112
218
1357
1.97
12.79
4.3
8.1
38.29
38.28
g/l
0.01
200
1307
67
254
2.83
12.66
1.4
1.7
0.16
0.24
mg/l
1.03
23
116
505
4341
2.88
10.81
11.1
9.3
29.18
27.68
u/l
0.69
499
4242
269
1868
1.83
10.73
7.2
10.0
—
—
—
0
0
185
1165
1.86
9.96
5.1
4.8
8.83
8.84
mmol/l
0.00
161
1073
205
1339
1.82
9.77
2.0
1.9
1.39
1.32
mmol/l
0.41
182
1228
96
491
2.13
9.36
6.4
3.1
—
—
—
0
0
80
383
2.24
9.18
1.6
1.5
477.22
19198145.69
pmol/l
0.50
65
349
322
2442
1.73
8.80
8.2
9.4
0.64
0.63
%
0.16
301
2348
139
827
1.88
8.79
2.9
3.2
597.19
577.42
mosm/kgh2o
0.38
124
733
224
1556
1.71
8.30
7.2
7.6
—
—
—
0
0
17
20
8.62
8.28
2.4
2.1
21.35
14.24
umol/l
1.30
17
20
234
1647
1.70
8.24
5.3
6.8
18.37
18.17
umol/l
0.03
219
1537
401
3282
1.77
7.88
4.7
3.4
2.75
2.73
mmol/l
0.16
381
3144
79
401
2.10
7.80
4.0
13.4
105.57
105.13
mmol/l
0.31
79
401
319
2462
1.67
7.73
8.3
9.4
8.10
8.45
%
2.13
299
2367
318
2453
1.66
7.71
8.2
9.4
2.87
3.18
%
1.47
295
2356
330
2573
1.67
7.65
8.0
9.2
0.04
0.04
e9/l
0.50
266
2152
338
2655
1.67
7.58
9.0
10.0
0.19
0.21
e9/l
1.64
279
2260
315
2434
1.65
7.50
10.8
11.2
0.00
0.00
e9/l
1.18
241
1866
14
527
0.24
7.43
1.1
1.3
—
—
—
0
0
328
2580
1.63
7.11
8.1
9.2
0.56
0.56
e9/l
0.04
265
2159
363
2931
1.66
7.07
5.5
3.9
35.97
36.21
mmol/mol
0.19
340
2821
399
3302
1.71
7.06
4.6
3.3
4.43
4.50
mmol/l
0.87
380
3183
183
1249
1.67
6.99
3.8
4.0
0.36
0.23
e6/l
0.51
131
897
395
3266
1.69
6.95
4.5
3.3
1.29
1.39
mmol/l
6.68
375
3131
349
2801
1.63
6.85
14.6
11.4
3.64
3.65
e9/l
0.04
290
2340
196
1373
1.64
6.70
3.9
4.2
19.44
41.59
e6/l
1.55
142
1019
333
2659
1.60
6.53
8.0
9.1
2.33
2.29
e9/l
0.28
279
2296
120
742
1.76
6.51
5.0
11.3
—
—
—
0
0
24
74
3.30
6.48
1.6
2.4
—
—
—
0
0
93
1460
0.55
6.34
1.7
1.9
—
—
—
0
0
342
2759
1.59
6.33
5.0
3.8
31.34
30.98
u/l
0.06
332
2667
224
1643
1.58
6.23
5.1
5.1
19.53
48.53
e6/l
1.27
149
1074
322
2570
1.57
6.17
8.4
9.2
34.15
34.20
%
0.03
305
2495
76
416
1.93
6.07
2.4
2.0
2.39
2.41
mmol/l
1.06
64
358
42
184
2.36
5.92
3.0
4.4
7.38
7.32
ph
1.77
33
144
73
398
1.93
5.89
2.2
2.5
24.71
31.83
u/l
2.38
58
325
125
808
1.68
5.73
4.0
10.1
1.17
1.08
mmol/l
0.13
101
655
175
1233
1.59
5.67
3.8
4.0
—
4.00
estimate
—
0
5
95
571
1.78
5.64
5.0
2.2
—
—
—
0
0
125
813
1.67
5.58
3.9
10.2
7.37
7.37
ph
0.33
85
544
314
2527
1.53
5.53
8.4
9.0
50.86
50.90
%
0.02
299
2457
161
1119
1.59
5.50
2.3
3.3
2.15
2.49
mg/l
1.72
142
1005
120
778
1.67
5.41
4.9
11.0
1.24
1.31
mmol/l
1.51
112
746
18
53
3.43
5.23
4.9
3.3
1.59
1.73
mmol/l
0.21
18
53
359
2993
1.53
5.21
3.8
2.9
1.28
1.16
mmol/l
1.66
338
2856
79
460
1.81
5.20
2.6
2.4
8.81
12.38
nmol/l
2.31
69
430
139
945
1.60
5.17
3.0
2.9
51.94
57.72
u/l
1.40
128
892
14
27
5.22
5.05
7.5
4.9
320.22
240.58
umol/l
—
9
12
130
881
1.60
4.87
2.6
3.4
8.66
6.51
e6/l
0.70
118
789
20
66
3.07
4.87
6.3
8.4
1.70
2.22
mmol/l
0.43
12
32
64
357
1.87
4.83
2.2
2.2
6.71
6.21
u/l
0.18
42
227
120
801
1.61
4.78
3.6
3.7
1.55
1.81
e6/l
0.22
53
404
116
778
1.60
4.52
1.2
1.3
—
—
—
0
0
85
528
1.70
4.47
2.3
5.4
6.55
6.87
umol/l
0.07
68
437
95
608
1.66
4.46
2.2
3.1
15.15
14.38
umol/l
0.41
88
582
5
214
0.22
4.20
1.0
1.0
1.39
1.46
g/l
—
5
214
69
412
1.75
4.18
1.4
1.3
135.80
134.22
u/ml
0.01
15
139
14
41
3.43
4.12
1.1
1.1
264.79
287.50
mg/l
0.38
14
36
88
565
1.64
4.08
3.4
4.2
316.54
92.23
mg/l
0.44
56
426
101
673
1.59
4.02
5.1
2.2
—
—
—
0
0
13
31
4.21
3.98
1.8
3.1
—
—
—
0
0
10
18
5.56
3.94
1.1
1.1
—
—
—
0
0
87
562
1.63
3.93
2.1
3.1
2.58
2.48
g/l
0.76
76
533
536
5064
3.03
3.87
24.4
17.4
275.64
265.62
e9/l
3.27
520
4917
42
221
1.95
3.79
3.2
14.0
139.52
130.02
g/l
3.25
42
215
536
5069
2.98
3.76
24.3
17.3
4.76
4.68
e12/l
3.69
517
4910
6
216
0.27
3.71
1.5
1.1
0.84
0.87
g/l
—
6
216
23
484
0.45
3.70
1.5
1.6
777.52
966.52
mu/l
0.64
17
435
536
5072
2.95
3.70
24.4
17.3
6.90
6.91
e9/l
0.02
519
4906
51
289
1.82
3.69
4.2
5.3
0.23
0.49
%
0.63
13
97
8
12
6.66
3.64
1.0
3.8
—
—
—
0
0
229
1829
1.40
3.64
1.8
1.8
1.77
3.11
u/ml
0.85
44
373
127
1666
0.68
3.61
2.9
2.4
—
—
—
0
0
49
277
1.82
3.57
1.9
2.0
0.00
0.00
estimate
-0.00
15
81
25
111
2.28
3.49
1.8
1.3
337.64
374.65
ug/g
0.31
14
64
104
722
1.52
3.44
5.0
2.1
—
—
—
0
0
75
1087
0.63
3.42
2.4
2.0
—
—
—
0
0
104
723
1.52
3.42
5.0
2.2
—
—
—
0
0
19
75
2.55
3.40
3.2
7.2
—
—
—
0
0
85
566
1.57
3.39
4.0
5.0
1.18
40.55
mg/mmol
0.83
50
410
104
725
1.51
3.37
5.1
2.2
—
—
—
0
0
466
4255
1.54
3.23
21.3
15.6
13.11
13.11
%
0.03
460
4211
112
805
1.47
3.12
3.3
4.1
—
—
—
0
0
119
867
1.45
3.09
2.5
2.5
—
—
—
0
0
51
306
1.71
3.07
4.7
5.6
0.73
0.60
%
0.08
11
102
61
385
1.63
3.04
2.0
2.0
13.26
12.82
iu/l
0.04
40
260
8
16
4.99
3.02
1.0
1.4
—
—
—
0
0
49
294
1.71
2.95
4.7
5.7
0.00
0.03
%
—
10
90
49
300
1.67
2.75
4.7
5.9
0.00
0.04
%
—
7
89
35
196
1.81
2.68
2.3
13.4
0.64
0.58
%
0.57
35
196
274
2334
1.32
2.61
3.4
3.5
60.97
64.35
ug/l
0.20
255
2238
142
1099
1.37
2.59
5.1
6.0
1.07
1.14
inr
0.82
124
913
212
1744
1.33
2.58
3.9
3.2
6.39
6.27
ph
0.67
94
881
99
721
1.43
2.57
3.2
2.0
—
—
—
0
0
30
163
1.86
2.53
1.8
1.7
22.91
28.77
ng/l
0.33
30
163
6
11
5.43
2.52
1.0
1.5
—
—
—
0
0
103
763
1.41
2.43
7.1
9.3
5.06
5.02
kpa
0.25
98
742
102
758
1.40
2.36
7.2
9.3
7.40
7.41
ph
1.28
87
615
204
1687
1.31
2.34
1.7
1.7
1.69
1.74
g/l
0.17
91
922
110
1387
0.73
2.31
2.5
2.1
—
—
—
0
0
25
135
1.87
2.17
1.9
16.6
61.96
72.44
%
1.51
25
135
9
203
0.43
2.12
1.8
1.5
—
—
—
0
0
307
2703
1.27
2.09
4.6
4.2
—
3.30
—
0
5
89
1143
0.72
2.08
1.9
1.7
—
—
—
0
0
483
4530
1.44
2.03
11.5
8.5
—
—
—
0
0
32
193
1.68
1.95
1.3
1.3
—
—
—
0
0
5
11
4.52
1.92
2.4
1.3
112.20
56.91
nmol/24h
—
5
11
128
1539
0.77
1.89
1.5
1.7
—
—
—
0
0
24
135
1.79
1.86
1.2
1.6
—
—
—
0
0
48
326
1.50
1.81
2.1
2.6
0.78
1.19
ug/l
1.32
38
293
21
115
1.83
1.78
2.2
3.7
0.85
7.52
index
1.58
13
73
63
453
1.42
1.78
1.5
1.9
—
—
—
0
0
30
185
1.63
1.71
1.5
2.0
31.90
35.03
nmol/l
0.26
30
179
0
47
0.00
1.71
0.0
5.4
—
8.04
—
0
47
0
47
0.00
1.71
0.0
2.7
—
43.38
—
0
47
23
133
1.74
1.65
1.9
2.2
2.19
4.12
iu/l
—
6
54
15
76
1.97
1.60
1.7
1.5
4.10
12.42
u/l
3.48
15
66
5
14
3.55
1.60
4.4
2.7
—
—
—
0
0
8
32
2.49
1.57
3.3
4.4
1577.13
584.53
u/ml
—
8
32
81
622
1.33
1.55
1.3
1.5
304.62
403.11
titre
0.49
13
90
23
136
1.70
1.54
1.4
1.1
—
—
—
0
0
0
43
0.00
1.52
0.0
1.1
—
—
—
0
0
0
44
0.00
1.51
0.0
1.0
—
—
—
0
0
5
15
3.31
1.50
2.2
3.0
20.62
26.80
umol/l
—
5
15
5
15
3.31
1.50
2.2
2.9
32.06
33.67
umol/l
—
5
15
33
216
1.54
1.50
6.2
15.4
125.61
122.57
g/l
0.43
33
207
39
268
1.47
1.42
5.8
14.5
0.42
0.28
mmol/l
0.09
32
223
92
1114
0.78
1.41
3.0
2.9
1.47
0.00
estimate
0.49
34
325
17
95
1.79
1.39
1.1
1.1
—
—
—
0
0
22
133
1.66
1.38
2.0
17.4
61.73
71.79
%
1.30
22
133
120
989
1.25
1.35
3.8
3.0
1.02
1.02
kg/l
0.39
83
613
5
17
2.92
1.34
2.0
3.0
108.00
105.94
mmol/l
—
5
17
5
17
2.92
1.34
2.0
3.0
1.22
1.19
mmol/l
—
5
17
16
89
1.80
1.33
1.0
1.1
—
—
—
0
0
26
166
1.57
1.33
1.1
1.1
—
—
—
0
0
76
594
1.30
1.31
3.1
3.3
61.60
1293.11
ng/l
4.18
35
311
8
33
2.41
1.30
1.0
1.4
—
—
nmol/l
—
0
0
32
451
0.68
1.30
1.6
1.4
—
—
—
0
0
21
128
1.64
1.29
6.3
8.5
25.07
24.51
mmol/l
0.41
21
121
5
18
2.76
1.27
2.0
2.9
4.04
3.86
mmol/l
—
5
18
35
242
1.46
1.26
1.3
1.1
—
—
—
0
0
25
162
1.55
1.22
2.0
2.1
0.00
0.00
estimate
-0.00
12
68
7
143
0.48
1.21
1.0
1.2
—
—
—
0
0
5
19
2.61
1.20
1.4
1.2
77.80
71.95
umol/l
—
5
19
38
270
1.42
1.20
6.0
14.4
5.21
5.23
kpa
0.08
38
257
38
270
1.42
1.20
5.9
14.4
11.80
15.65
kpa
5.81
38
257
147
1662
0.83
1.19
2.4
3.2
—
—
estimate
—
0
0
38
271
1.41
1.17
6.0
14.5
7.40
7.41
ph
0.16
14
98
8
38
2.09
1.17
1.3
1.3
116.50
115.18
pmol/l
—
8
38
0
35
0.00
1.15
0.0
3.0
—
4.89
—
0
35
14
230
0.59
1.14
2.0
2.0
—
—
—
0
0
35
249
1.41
1.11
6.2
15.5
94.63
96.06
%
0.26
35
238
7
32
2.17
1.07
1.7
1.7
8.23
9.72
umol/l
—
7
32
472
4498
1.26
1.06
13.2
11.4
21.23
22.74
mg/l
0.48
350
3307
11
188
0.57
1.05
1.1
1.5
—
—
—
0
0
43
323
1.34
1.00
2.3
1.9
—
—
—
0
0
108
1236
0.83
0.98
1.8
1.8
—
—
—
0
0
15
91
1.64
0.97
1.8
3.3
141.67
138.88
g/l
0.24
15
78
0
31
0.00
0.96
0.0
1.5
—
—
—
0
0
0
31
0.00
0.96
0.0
1.2
—
272.11
—
0
31
20
131
1.53
0.96
1.4
1.5
0.22
0.33
nmol/l
0.91
15
104
18
115
1.56
0.96
1.6
1.5
—
—
—
0
0
11
61
1.80
0.95
1.3
1.9
—
—
—
0
0
0
32
0.00
0.95
0.0
1.8
—
97.25
—
0
32
25
173
1.45
0.93
6.0
16.4
17.12
16.05
%
1.24
25
164
22
149
1.48
0.91
2.1
3.1
40.95
19.84
mu/l
0.47
22
142
42
320
1.32
0.90
2.3
2.2
14.82
17.30
au/ml
—
5
30
21
295
0.69
0.89
1.2
1.4
204.80
249.59
miu/ml
—
5
156
131
1459
0.85
0.88
3.2
3.1
0.68
0.02
estimate
0.48
37
332
39
296
1.32
0.87
1.3
1.2
—
28.90
—
0
13
12
189
0.62
0.86
1.5
1.6
—
—
—
0
0
14
87
1.60
0.84
1.0
1.0
1.37
1.38
g/l
0.07
14
82
17
112
1.51
0.81
2.3
2.4
—
—
—
0
0
21
145
1.45
0.81
1.1
1.1
—
—
—
0
0
19
266
0.69
0.80
1.0
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
3.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
13
81
1.60
0.78
4.7
5.9
1.86
1.84
ug/l
0.01
13
81
80
674
1.20
0.76
7.9
8.9
—
—
—
0
0
26
190
1.37
0.75
7.4
16.6
95.32
95.74
%
0.32
26
190
109
1215
0.86
0.74
2.4
3.0
—
—
—
0
0
7
39
1.78
0.72
1.1
1.4
148.61
230.83
pmol/l
—
7
39
225
2063
1.13
0.70
3.7
3.5
0.00
0.00
estimate
-0.00
49
398
38
299
1.27
0.68
3.1
3.7
—
—
—
0
0
226
2080
1.12
0.66
3.8
3.6
0.00
0.00
estimate
-0.00
48
372
92
799
1.16
0.63
1.8
3.5
0.64
1.52
mg/l
2.13
65
563
11
70
1.56
0.62
4.1
6.1
—
—
—
0
0
91
792
1.16
0.61
4.4
2.4
13.76
53.45
ng/l
0.87
44
331
12
79
1.51
0.60
1.2
4.6
4.16
3.37
e9/l
0.79
12
79
224
2072
1.11
0.58
3.8
3.5
0.00
3.19
estimate
0.50
47
385
6
34
1.75
0.58
1.0
1.1
—
—
—
0
0
15
204
0.72
0.57
1.2
1.2
—
—
—
0
0
5
86
0.57
0.56
1.0
1.3
—
—
—
0
0
15
203
0.72
0.56
1.2
1.2
—
—
—
0
0
5
89
0.55
0.56
2.0
2.6
—
23.16
—
0
5
22
166
1.32
0.55
2.9
4.3
52.75
161.27
ng/l
2.73
16
144
23
175
1.31
0.55
1.8
1.8
0.33
0.61
ug/l
—
10
62
9
62
1.44
0.52
1.0
1.5
—
275.00
—
0
14
37
302
1.22
0.52
1.4
1.6
—
—
—
0
0
6
40
1.49
0.51
1.0
1.1
—
—
—
0
0
48
552
0.84
0.50
1.6
1.7
—
—
—
0
0
12
164
0.72
0.48
1.3
1.6
—
10.33
—
0
7
32
260
1.23
0.47
1.2
1.2
—
—
—
0
0
7
48
1.44
0.46
2.3
5.2
0.86
0.88
index
—
7
48
5
81
0.61
0.46
1.8
1.1
—
—
—
0
0
15
110
1.36
0.46
2.1
5.9
—
—
—
0
0
10
68
1.46
0.44
1.4
2.3
—
—
—
0
0
9
126
0.70
0.44
1.2
1.2
0.22
2.23
u/ml
—
9
76
27
218
1.23
0.43
2.9
3.8
0.42
0.14
e6/l
0.38
27
208
5
32
1.55
0.42
1.2
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
5
34
1.46
0.40
1.4
1.4
—
—
—
0
0
18
223
0.79
0.39
1.2
1.6
—
—
—
0
0
10
70
1.42
0.39
3.4
12.4
0.89
0.84
%
—
10
60
109
994
1.10
0.38
2.0
3.6
120.79
112.27
ug/g
0.05
82
812
9
70
1.27
0.36
1.6
1.2
—
—
—
0
0
11
80
1.36
0.36
3.5
11.6
1.84
1.56
%
0.39
11
68
13
98
1.32
0.35
3.0
7.4
37.00
36.99
°c
0.08
13
98
31
261
1.18
0.35
1.1
1.1
1.75
10.26
u/ml
6.15
20
172
6
43
1.38
0.34
1.8
2.4
—
—
—
0
0
6
44
1.35
0.34
1.2
1.1
—
—
—
0
0
6
45
1.32
0.33
1.3
1.0
170.33
244.40
mg/l
—
6
39
16
196
0.80
0.33
1.3
1.2
—
—
—
0
0
6
46
1.29
0.32
1.2
1.2
—
—
—
0
0
6
46
1.29
0.32
1.2
1.2
—
—
—
0
0
10
73
1.36
0.32
1.1
1.0
—
—
—
0
0
41
357
1.14
0.31
1.1
1.2
—
—
—
0
0
13
100
1.29
0.31
1.0
1.2
—
—
—
0
0
56
499
1.12
0.31
7.0
13.8
4.87
5.53
mmol/l
0.87
56
489
12
92
1.29
0.29
2.1
4.4
—
—
—
0
0
43
378
1.13
0.29
1.3
1.4
—
—
—
0
0
8
105
0.75
0.29
1.9
3.5
9.63
9.05
%
—
8
105
8
109
0.72
0.29
1.8
3.4
41.56
38.49
%
—
8
109
8
61
1.30
0.28
1.1
1.1
—
—
—
0
0
18
148
1.21
0.26
2.1
4.6
—
—
—
0
0
5
71
0.69
0.26
2.0
1.6
0.44
0.52
e9/l
—
5
71
10
76
1.30
0.26
1.0
1.2
0.25
0.42
g/l
—
10
61
10
76
1.30
0.26
1.0
1.2
1.90
2.36
g/l
—
10
61
10
76
1.30
0.26
1.0
1.2
5.40
6.16
g/l
—
10
61
10
76
1.30
0.26
1.0
1.2
—
—
—
0
0
44
479
0.90
0.25
1.6
2.2
—
—
—
0
0
108
1007
1.07
0.24
3.4
3.6
0.00
0.01
estimate
0.74
46
372
48
519
0.90
0.24
1.6
1.5
—
—
—
0
0
30
262
1.14
0.23
1.2
1.2
—
—
—
0
0
19
160
1.18
0.23
2.0
4.4
2.29
9.20
e6/l
0.77
14
103
5
39
1.27
0.22
1.4
3.7
-0.08
-0.05
mmol/l
—
5
32
7
92
0.75
0.22
2.1
4.2
—
—
—
0
0
11
133
0.81
0.22
1.0
1.1
—
16.68
—
0
26
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
10.3
—
—
—
0
0
0
13
0.00
0.20
0.0
1.0
—
0.06
—
0
5
0
13
0.00
0.20
0.0
1.6
—
—
—
0
0
0
13
0.00
0.20
0.0
2.5
—
—
—
0
0
9
111
0.80
0.20
1.9
3.9
14.89
14.80
%
—
9
111
6
49
1.21
0.20
2.0
2.0
26.17
30.10
mg/l
—
6
31
6
51
1.16
0.19
1.3
1.0
13.83
36.67
iu/ml
—
6
51
11
89
1.22
0.19
2.1
9.3
—
—
—
0
0
16
183
0.86
0.19
2.1
1.6
1.21
1.16
g/l
0.26
16
177
33
358
0.90
0.18
5.2
5.3
64.72
63.38
e9/l
0.10
21
203
13
151
0.85
0.18
1.2
1.3
—
—
—
0
0
7
58
1.19
0.18
2.1
2.3
—
—
—
0
0
24
211
1.13
0.18
5.5
9.3
154.38
361.42
mg/l
2.89
16
165
105
992
1.05
0.17
4.7
5.0
—
—
—
0
0
47
432
1.08
0.16
4.0
2.5
2546.15
5648.69
u/l
0.55
13
163
6
76
0.78
0.15
2.3
1.9
—
—
—
0
0
29
261
1.10
0.15
1.9
1.7
6.30
6.31
ph
0.02
22
155
8
96
0.82
0.14
1.9
3.6
29.38
26.74
%
—
8
96
24
216
1.10
0.13
1.3
1.3
—
—
—
0
0
31
283
1.09
0.13
1.1
1.1
1.14
6.36
u/ml
4.35
20
196
28
256
1.08
0.11
1.1
1.1
0.12
0.41
u/ml
1.30
17
136
58
599
0.95
0.11
2.6
4.0
321.74
312.04
umol/l
0.28
50
567
65
616
1.05
0.10
1.4
1.3
11.90
18.63
iu/ml
0.91
14
137
46
477
0.95
0.10
6.4
2.7
4.46
4.69
e9/l
0.11
41
432
31
326
0.93
0.10
1.7
1.9
—
—
—
0
0
63
599
1.04
0.09
1.6
1.7
—
—
—
0
0
13
141
0.91
0.07
1.3
1.2
—
—
—
0
0
38
392
0.95
0.07
1.1
1.2
1.63
2.45
u/ml
0.42
25
291
42
399
1.04
0.06
1.1
1.2
2.50
6.91
u/ml
2.30
27
313
11
98
1.11
0.06
2.4
21.5
12.98
12.19
%
0.31
11
98
41
394
1.03
0.03
1.1
1.2
1.21
0.78
u/ml
0.33
25
279
58
561
1.02
0.03
1.4
1.2
19.31
5.09
u/ml
0.36
13
201
12
112
1.06
0.01
1.4
1.4
28.02
13.62
u/ml
—
7
93
86
842
1.01
0.00
1.9
1.7
—
—
—
0
0
16
152
1.04
0.00
1.6
1.7
4.60
5.61
u/ml
—
5
42
10
93
1.06
0.00
2.9
11.3
23.82
24.22
mmol/l
—
10
83
17
165
1.02
0.00
1.0
1.0
—
—
—
0
0
10
100
0.99
0.00
1.1
1.1
—
—
—
0
0
18
178
1.00
0.00
1.9
3.0
54.75
53.26
%
0.17
18
178
12
123
0.96
0.00
1.5
2.0
—
—
—
0
0
12
123
0.96
0.00
1.5
2.0
—
—
—
0
0
12
123
0.96
0.00
1.5
2.0
—
—
—
0
0
12
123
0.96
0.00
1.5
2.0
—
—
—
0
0
44
431
1.01
0.00
1.1
1.3
2.24
2.88
u/ml
0.25
31
315
16
160
0.99
0.00
1.2
1.5
0.65
2.96
u/ml
1.83
11
109
0
9
0.00
0.00
0.0
3.3
—
138.78
—
0
9
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.8
—
0.46
—
0
9
0
9
0.00
0.00
0.0
3.3
—
28.67
—
0
9
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
16.8
—
14.00
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
68.00
—
0
8
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
27.50
—
0
6
6
65
0.91
-0.00
3.0
9.2
5.55
5.74
pmol/l
—
6
65
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
27.74
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
42.31
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
13.64
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
9
93
0.95
-0.00
5.8
5.0
2.67
9.79
u/ml
—
9
93
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
2.67
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint F5_PERVASIVE and mortality.

Females

Parameter HR [95% CI] p-value
F5_PERVASIVE 4.437 [2.83, 6.96] < 0.001
Birth year 0.992 [0.98, 1.0] 0.09

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 2735 females with F5_PERVASIVE died.

Males

Parameter HR [95% CI] p-value
F5_PERVASIVE 2.447 [1.92, 3.12] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 7819 males with F5_PERVASIVE died.

Mortality risk

Mortality risk for people of age

years, who have F5_PERVASIVE.

N-year risk Females Males
1 0.416% 0.596%
5 2.348% 2.963%
10 6.356% 6.658%
15 12.009% 12.015%
20 20.443% 20.517%

Relationships between endpoints

↥

Index endpoint: F5_PERVASIVE – Pervasive developmental disorders excl. Autism + Asperger

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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