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Graves disease, strict definition

Endpoint Browser PheWeb

E4_GRAVES_STRICT

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

  • GRAVES_COND
  • and not AMIODARONE
9738

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

4613

6. Filter based on genotype QC (FinnGen only)

4417

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

↥

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 23064 18836 4057
Only index persons 22484 18513 3971
Unadjusted period prevalence (%)
Whole population 0.46 0.54 0.11
Only index persons 0.59 0.68 0.15
Median age at first event (years)
Whole population 49.31 49.21 50.36
Only index persons 49.26 49.12 49.95

-FinnGen-

Key figures

All Female Male
Number of individuals 4417 3732 685
Unadjusted period prevalence (%) 1.17 1.32 0.31
Median age at first event (years) 50.45 49.67 54.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
4613
Matched controls
46130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03BB01
ATC
carbimazole; oral
3983.8
307.7
4514
522
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
30.7
307.7
435
156
H03AA01
ATC
levothyroxine sodium; systemic
12.5
307.7
3348
8071
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
116.7
307.7
2271
380
BAA60
NOMESCO Finland
Total thyroidectomy
47.5
307.7
1438
436
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
59.9
307.7
596
114
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
14.6
307.7
436
327
C07AA05
ATC
propranolol; systemic
5.1
307.7
2191
6978
104
Kela drug reimbursment
Thyroid insufficiency
9.5
307.7
1275
1775
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
20269.2
307.7
4554
175
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
103.3
307.7
940
114
T85
ICPC
Hyperthyroidism/thyrotoxicosis
47.3
307.7
342
78
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
319.4
307.7
610
22
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
31.6
307.7
473
166
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
37.1
307.7
971
329
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
35.7
289.7
182
53
E05.89
ICD-10 Finland
Other thyrotoxicosis
59.8
259.9
145
25
C07AB07
ATC
bisoprolol; oral
2.8
253.9
2479
13506
T86
ICPC
Hypothyroidism/myxoedema
4.9
229.8
554
1254
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.5
215.6
574
1405
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
14.0
204.6
190
141
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
26.9
198.3
136
52
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.9
197.4
468
1041
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
46.7
194.4
114
25
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
7.2
182.1
280
412
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
171.7
1926
10647
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
19.5
167.9
131
69
H062, E050,
ICD-10 Finland
345.5
167.3
168
5
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
288.2
163.8
166
6
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.8
162.9
1026
4302
H03BA02
ATC
propylthiouracil; oral
73.0
159.1
86
12
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
126.4
2300
14906
H05.2
ICD-10 Finland
Exophthalmic conditions
33.1
117.0
75
23
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
11.5
116.9
122
109
E03
ICD-10 Finland
Other hypothyroidism
3.0
108.0
515
1831
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
20.1
102.8
79
40
CA1AD
NOMESCO Finland
Orbita CT
26.3
101.4
70
27
A11CC03
ATC
alfacalcidol; systemic
5.4
83.9
170
327
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
5.4
76.3
154
295
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
20.2
73.1
56
28
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.4
73.0
145
274
E83.51
ICD-10 Finland
Hypocalcemia
8.7
66.3
84
98
E05.5
ICD-10 Finland
Thyroid crisis or storm
140.1
65.1
69
5
106
Kela drug reimbursment
Hypoparathyroidism
11.1
62.4
66
60
E06.3
ICD-10 Finland
Autoimmune thyroiditis
6.9
62.2
96
141
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.0
54.3
251
869
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.7
48.1
273
1055
H50.2
ICD-10 Finland
Vertical strabismus
6.5
43.8
71
110
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
4.3
43.2
114
273
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
70.5
37.0
42
6
WX402
NOMESCO Finland
General anaesthesia
1.6
36.1
1078
7407
ZXA10
NOMESCO Finland
Bilateral
1.7
35.3
759
4796
R00.2
ICD-10 Finland
Palpitations
1.9
35.1
467
2557
H53.2
ICD-10 Finland
Diplopia
2.8
34.6
174
631
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
171.2
32.7
34
*
XCK00
NOMESCO Finland
Perimetry
2.3
32.4
265
1210
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
31.5
768
5002
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
2.8
30.2
157
579
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
29.8
617
3847
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.9
29.2
427
2406
A11CC02
ATC
dihydrotachysterol; oral
10.4
28.0
31
30
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
3.7
27.9
90
250
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
27.4
1072
7745
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
23.9
26.9
38
16
C07AB02
ATC
metoprolol; systemic
1.6
26.1
661
4328
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
25.7
1448
11195
E06.9
ICD-10 Finland
Thyroiditis, unspecified
6.4
24.8
41
65
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
6.3
24.0
40
64
CEC00
NOMESCO Finland
Recession of extraocular muscle
7.0
23.7
36
52
CAC44
NOMESCO Finland
Combined decompression of orbit
87.2
23.7
26
*
CAC20
NOMESCO Finland
Lateral decompression of orbit
241.2
23.7
24
*
H50.6
ICD-10 Finland
Mechanical strabismus
33.5
23.3
30
9
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
4.0
23.0
64
160
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
4.8
22.7
50
104
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
231.1
22.6
23
*
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
20.8
22.5
33
16
H02AB06
ATC
prednisolone; systemic
1.4
21.6
1998
16641
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
20.8
883
6438
K04
ICPC
Palpitations/awareness of heart
1.9
19.7
255
1379
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.6
19.7
495
3224
H50.8
ICD-10 Finland
Other specified strabismus
15.3
19.7
32
21
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.1
19.5
182
877
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
2.5
19.0
122
501
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.7
18.0
98
372
WF099
NOMESCO Finland
Other radiotherapy
5.3
17.9
36
69
2AB04, ,
NOMESCO Finland
7.3
17.8
26
36
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
19.3
16.8
25
13
ZX120
NOMESCO Finland
Intravenous
1.7
16.8
356
2223
K90.0
ICD-10 Finland
Coeliac disease
2.2
16.3
140
653
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
+∞
15.6
15
*
BA1AE, ,
SPAT
2.6
15.5
88
341
K80
ICPC
Cardiac arrhythmia NOS
1.6
15.4
347
2198
N02BE01
ATC
paracetamol; systemic, rectal
1.4
15.1
4000
37810
E05.81
ICD-10 Finland
Overproduction of thyroid-stimulating hormone
45.1
15.0
18
*
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
10.8
14.9
28
26
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
1.9
14.9
173
904
H02AB07
ATC
prednisone; oral
1.5
14.8
518
3620
G73.0*E05.9
ICD-10 Finland
Myasthenic syndromes in thyrotoxicosis [hyperthyroidism]
+∞
14.6
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
14.5
1704
14415
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
2.2
14.4
125
587
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
12.7
13.9
24
19
CA1BD
NOMESCO Finland
Extensive orbita CT
20.1
13.8
20
10
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
75.4
13.6
15
*
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
75.4
13.6
15
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
3.6
13.5
43
119
H04AA01
ATC
glucagon; nasal, parenteral
2.3
13.2
103
463
T89
ICPC
Diabetes insulin dependent
1.9
12.9
161
862
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
14.7
11.8
19
13
E06.1
ICD-10 Finland
Subacute thyroiditis
3.2
11.6
45
142
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
65.1
11.6
13
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.7
11.4
220
1340
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
2.3
11.4
87
388
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
11.3
1452
12323
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
11.2
791
6214
E20.8
ICD-10 Finland
Other hypoparathyroidism
25.1
11.1
15
6
E89.1
ICD-10 Finland
Postprocedural hypoinsulinaemia
20.1
11.1
16
8
A04
ICPC
Weakness/tiredness general
1.4
11.0
641
4893
WX110
NOMESCO Finland
Infiltration anesthesia
1.3
10.9
3200
29687
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
3.2
10.7
41
129
R53
ICD-10 Finland
Malaise and fatigue
1.3
10.6
1072
8830
E07.89
ICD-10 Finland
Other specified disorders of thyroid
9.2
10.5
21
23
N07BA03
ATC
varenicline; oral
1.7
10.5
201
1224
O992, E050,
ICD-10 Finland
+∞
10.4
10
*
R06.0
ICD-10 Finland
Dyspnoea
1.3
10.4
989
8081
XCK10
NOMESCO Finland
Photography of fundus of eye
1.5
10.3
281
1863
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
8.8
10.3
21
24
A02BC02
ATC
pantoprazole; systemic
1.2
10.2
2863
26322
207
Kela drug reimbursment
Chronic arrhythmias
1.5
10.1
361
2533
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.5
10.0
304
2061
R63.4
ICD-10 Finland
Abnormal weight loss
1.8
10.0
136
751
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
9.9
1283
10872
UDQ12
NOMESCO Finland
Flexible laryngoscopy
1.6
9.5
215
1367
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
9.4
374
2675
TFP20
NOMESCO Finland
Cardiodefibrillation
1.7
9.3
166
992
R25.1
ICD-10 Finland
Tremor, unspecified
1.9
9.3
106
553
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
9.5
9.2
18
19
SPAT1249
SPAT
Treatment-related counselling outside office
1.2
9.0
1572
13714
CS494
NOMESCO Finland
Other visual field testing
2.0
9.0
90
448
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
36.8
9.0
11
*
A10AB05
ATC
insulin aspart; parenteral
1.5
9.0
239
1576
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
9.0
692
5492
A60
ICPC
General and Unspecified, Result test/procedure
1.7
9.0
159
950
A10AB01
ATC
insulin (human); parenteral
1.8
8.9
122
676
CKC12
NOMESCO Finland
Photocoagulation of retina
1.8
8.9
133
758
CEW99
NOMESCO Finland
Other operation on extraocular muscle
12.5
8.9
15
12
H3601, E103,
ICD-10 Finland
3.0
8.8
37
123
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
1.5
8.7
233
1538
SPAT1097
SPAT
Recording of ECG
1.4
8.7
432
3211
M14.5*E05.9
ICD-10 Finland
Arthropathy in thyrotoxicosis [hyperthyroidism]
50.1
8.7
10
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
8.6
337
2403
XCH00
NOMESCO Finland
Eye pressure measurement
1.7
8.5
152
911
A10AE05
ATC
insulin detemir; parenteral
1.7
8.4
166
1020
E10
ICD-10 Finland
Type 1 diabetes mellitus
2.1
8.4
78
379
R49.08
ICD-10 Finland
Other specified dysphonia
1.9
8.1
94
495
E03.4
ICD-10 Finland
Atrophy of thyroid (acquired)
17.2
8.1
12
7
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
2.7
7.9
40
148
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.3
7.9
502
3879
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
3.1
7.8
32
105
A10AE04
ATC
insulin glargine; parenteral
1.5
7.8
275
1927
A12AA04
ATC
calcium carbonate; oral
2.5
7.7
46
185
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.5
7.6
217
1455
ZXE00
NOMESCO Finland
One hour or less
1.2
7.4
1520
13406
N05CF01
ATC
zopiclone; oral
1.2
7.4
1150
9877
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.2
7.4
873
7290
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
6.0
7.4
19
32
K29.4
ICD-10 Finland
Chronic atrophic gastritis
2.1
7.2
61
286
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
3.0
7.2
31
105
A99
ICPC
Disease/condition unspecnature/site
1.4
7.2
381
2864
A91
ICPC
Abnormal result investigation NOS
1.5
7.2
187
1231
F29
ICPC
Eye symptom/complaint other
1.3
7.1
418
3191
XCW12
NOMESCO Finland
Assessment of colour vision
10.0
7.0
13
13
A10AB04
ATC
insulin lispro; parenteral
1.7
6.9
112
654
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
2.4
6.9
44
183
K02.1
ICD-10 Finland
Caries of dentine
1.2
6.9
2594
24056
ZYC06
NOMESCO Finland
Real-time text-based remote transaction
4.0
6.9
19
48
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.3
6.8
408
3127
Z3231
NOMESCO Finland
Registered nurse
1.2
6.8
946
8035
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.3
6.7
686
5627
C07AA07
ATC
sotalol; systemic
1.9
6.7
78
412
A10AA01, ,
ATC
1.8
6.7
89
491
SGA02
NOMESCO Finland
Opening and preparing the root canals
1.3
6.7
478
3752
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
2.3
6.6
45
193
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
4.2
6.5
17
41
A10AA02, ,
ATC
1.8
6.5
97
554
A98
ICPC
Health maint/preventive medicine
1.6
6.5
4483
44089
E06.0
ICD-10 Finland
Acute thyroiditis
5.7
6.4
17
30
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
14.3
6.4
10
7
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.2
6.4
2365
21846
WX704
NOMESCO Finland
Intubation
1.4
6.3
288
2114
H50.52
ICD-10 Finland
Exophoria
2.2
6.3
51
236
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
1.7
6.3
105
620
O90.5
ICD-10 Finland
Postpartum thyroiditis
11.0
6.3
11
10
E8901, E050,
ICD-10 Finland
+∞
6.2
6
*
CE2W4
NOMESCO Finland
Eye movement mapping
5.3
6.1
17
32
A10AE06
ATC
insulin degludec; parenteral
1.7
6.1
114
694
R21
ICPC
Throat symptom/complaint
1.2
6.1
969
8325
WX290
NOMESCO Finland
Other blockage of nerve
1.2
6.1
2112
19383

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
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OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Dysthyroid exophthalmos
H06.2 (45542958)
Dysthyroid exophthalmos and Thyrotoxicosis with diffuse goitre
H06.2*E05.0 (2000503914)
SMOKING - SMOKE2: no - SMOKE3: never - SMOKE5: never
SMOKING-2-3-5 (2002330114)
Autoimmune thyroiditis
E06.3 (45557105)
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
2420A (2000402259)
Dysthyroid exophthalmos
H06.2*E05.9 (2000502261)
Total thyroidectomy
BAA60 (2001300753)
Eye and orbita MRI examination with high intensity magnet
CA1BG (2001300865)
Decompression of orbit to sinuses
CAC30 (2001300892)
Combined decompression of orbit
CAC44 (2001300895)
Radioiodine therapy of thyroid tissue
XX7CT (2001311149)
Hypoparathyroidism
106 (2001600106)
SMOKING - SMOKE2: no - SMOKE3: former - SMOKE5: Unspecified
SMOKING-2-2-0 (2002330110)
SMOKING - SMOKE2: no - SMOKE3: Unspecified - SMOKE5: Unspecified
SMOKING-2-0-0 (2002330112)
SMOKING - SMOKE2: no - SMOKE3: never - SMOKE5: Unspecified
SMOKING-2-3-0 (2002330113)
SMOKING - SMOKE2: yes - SMOKE3: current - SMOKE5: Unspecified
SMOKING-1-1-0 (2002330116)
propylthiouracil; oral
H03BA02 (21602762)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Thyrotoxicosis [hyperthyroidism]
E05 (45533007)
Abnormal results of thyroid function studies
R94.6 (45563335)
Thyroid crisis or storm
E05.5 (45566720)
Postprocedural hypoparathyroidism
E89.2 (45586178)
Thyrotoxicosis with diffuse goitre
E05.0 (45600628)
Chronic thyroiditis with transient thyrotoxicosis
E06.2 (45605391)
Other specified hypothyroidism
E03.89 (2000501408)
Hypocalcemia
E83.51 (2000501538)
Postirradiation hypothyroidism
E89.00 (2000501553)
Electrophysiological examination of eye
XCD10 (2001300413)
Thyroid ultrasound examination
BA1AE (2001300735)
Lobectomy and resection of contralateral lobe of thyroid gland
BAA50 (2001300752)
Orbita CT
CA1AD (2001300861)
Eye and orbita extensive MRI examination with high intensity magnet
CA1CG (2001300869)
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
CBK00 (2001300991)
Extensive structural and functional ultrasound examination of heart
FM1EE (2001303307)
Intubation
WX704 (2001310820)
Radiotherapy with large shaped fields - isocentric therapy
ZX012 (2001311468)
Intravenous
ZX120 (2001311495)
Telephone, letter or other consultation without direct patient contact
ZY020 (2001311600)
Weakness/tiredness general
A04 (2002000145)
Hyperthyroidism/thyrotoxicosis
T85 (2002001127)
Hypothyroidism/myxoedema
T86 (2002001128)
carbimazole; oral
H03BB01 (21602765)
Thyrotropin receptor Ab [Units/volume] in Serum
5385-0 (3017044)
Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma
14928-6 (3026989)
Pediatric Medicine
37 (38004477)
Papillary adenocarcinoma, NOS, of thyroid gland
8260/3-C73.9 (44503609)
Vertical strabismus
H50.2 (45533348)
Convergent concomitant strabismus
H50.0 (45552716)
Thyrotoxicosis with toxic single thyroid nodule
E05.1 (45557104)
Hypothyroidism due to medicaments and other exogenous substances
E03.2 (45566718)
Mechanical strabismus
H50.6 (45567092)
Primary hyperparathyroidism
E21.0 (45571667)
Spontaneous vertex delivery
O80.0 (45577661)
Other specified special examinations
Z01.8 (45581003)
Other hypothyroidism
E03 (45581337)
Coeliac disease
K90.0 (45586745)
Thyrotoxicosis with toxic multinodular goitre
E05.2 (45600629)
Subacute thyroiditis
E06.1 (45600632)
Iron deficiency anaemia, unspecified
D50.9 (45605373)
Tachycardia, unspecified
R00.0 (45606790)
Thyrotoxicosis, unspecified
E05.9 (45586131)
Endocrinology
46 (38004485)
propranolol; oral, parenteral
C07AA05 (21601670)
Thyroperoxidase Ab [Units/volume] in Serum or Plasma
8099-4 (3027238)
Thyroxine (T4) free [Moles/volume] in Serum or Plasma
14920-3 (3008486)
Internal Medicine
11 (38004456)
Thyrotropin [Units/volume] in Serum or Plasma
3016-3 (3009201)
Thyroid insufficiency
104 (2001600104)
Subacute thyrotoxicosis
E05.80 (2000501412)
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
O99.2 (45534321)
Neck ultrasound examination
EP1AE (2001302284)
Supplier / Service Provider
OMOP5117446 (33004)
Postprocedural hypothyroidism
E89.0 (45552421)
Cytology report of Tissue fine needle aspirate Cyto stain
33718-8 (3043109)
Outpatient Visit
OP (9202)
Pharmacy visit
OMOP4822462 (581458)
Postsurgical hypothyroidism
E89.01 (2000501554)
pH of Serum or Plasma
2753-2 (3018418)
Atrial fibrillation and flutter
I48 (45596206)
Calcium.ionized [Moles/volume] in Serum or Plasma
1995-0 (3021347)
Neutrophils [#/volume] in Blood by Automated count
751-8 (3013650)
Nontoxic multinodular goitre
E04.2 (45576425)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
19072-8 (3016431)
Observation for other suspected diseases and conditions
Z03.80 (2000503756)
General Surgery
2 (38004447)
Nontoxic goitre, unspecified
E04.9 (45537948)
Cytology of thyroid with ultrasound quidance
BA3AT (2001300769)
Short blood count panel - Blood
55429-5 (40758558)
bisoprolol; oral
C07AB07 (21601689)
Office Visit
OMOP4822458 (581477)
Parathyrin.intact [Moles/volume] in Serum or Plasma
14866-8 (3010566)
levothyroxine sodium; oral, parenteral
H03AA01 (21602754)
12 lead EKG panel
34534-8 (3044889)
Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
6768-6 (3035995)
Thyroglobulin Ab [Units/volume] in Serum or Plasma
8098-6 (3025547)
Parathyrin.intact [Mass/volume] in Serum or Plasma
2731-8 (3000067)
Chronic arrhythmias
207 (2001600205)
Thyroxine (T4) free [Moles/volume] in Serum or Plasma by Dialysis
70217-5 (42868691)
Palpitations/awareness of heart
K04 (2002000547)
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
290 (2001600222)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
MCH [Entitic mass]
28539-5 (3035941)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
Platelets [#/volume] in Blood
26515-7 (3007461)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1742-6 (3006923)
Ophthalmology
18 (38004463)
Calcium [Moles/volume] in Serum or Plasma
2000-8 (3015377)
25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
68438-1 (40771025)
Outpatient Hospital
22 (8756)
Troponin T.cardiac [Mass/volume] in Serum or Plasma
6598-7 (3019800)
Emergency Room Visit
ER (9203)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
351 (2001600312)
CBC panel - Blood by Automated count
58410-2 (40761511)
alfacalcidol; oral, parenteral
A11CC03 (21600818)
Cardiodefibrillation
TFP20 (2001303224)
pH of Specimen
17433-4 (3019225)
EKG study
11524-6 (3013512)
Inpatient Hospital
21 (8717)
Papillary carcinoma of the thyroid gland (thyroid gland)
C73.91 (2000501197)
Otolaryngology
4 (38004449)
Medical doctor
Z2221 (2001311556)
varenicline; oral
N07BA03 (21604819)
Essential (primary) hypertension
I10 (45591453)
Glucose [Moles/volume] in Serum or Plasma
14749-6 (3013826)
Normoblasts [#/volume] in Blood
715-3 (3021589)
Other thyrotoxicosis
E05.89 (2000501414)
Palpitations
R00.2 (45558446)
Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma
13875-0 (3036185)
prednisolone; oral, parenteral
H02AB06 (21602734)
prednisolone
A07EA01 (21600653)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)
Diplopia
H53.2 (45576792)
Free T4 and TSH panel - Serum or Plasma
24348-5 (3001019)
potassium chloride; oral
A12BA01 (21600877)
Alkaline phosphatase.liver 1 [Enzymatic activity/volume] in Serum or Plasma
13874-3 (3035062)
Laboratory Visit
OMOP4822461 (32036)
Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method
4537-7 (3013707)
Emergency Medicine
93 (38004510)
More than three and less than five hours
ZXE20 (2001311408)
Upper gastrointestinal surgery
106 (44777669)
Abnormal weight loss
R63.4 (45568144)
Type 2 diabetes mellitus, without complications
E11.9 (45561952)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
Paroxysmal atrial fibrillation
I48.0 (45581776)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
Neutrophils [#/volume] in Blood
26499-4 (3017732)
Atherosclerotic heart disease
I25.1 (45596196)
dihydrotachysterol; oral
A11CC02 (21600817)
Paralysis of vocal cords and larynx
J38.0 (45543265)
prednisone
A07EA03 (21600655)
prednisone; oral
H02AB07 (21602735)
calcium (different salts in combination); oral
A12AA20 (21600872)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
47598-8 (3048816)
Celiac disease serology panel - Serum
94494-2 (36660697)
Alkaline phosphatase.intestinal [Enzymatic activity/volume] in Serum or Plasma
1778-0 (3020013)
IgA [Mass/volume] in Serum or Plasma
2458-8 (3007164)
Eosinophils [#/volume] in Blood
26449-9 (3013115)
Thyroglobulin [Mass/volume] in Serum or Plasma
3013-0 (3036535)
Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M
62238-1 (40764999)
Cardiac arrhythmia NOS
K80 (2002000607)
Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1920-8 (3013721)
Perimetry
XCK00 (2001301380)
Blood group antibody screen [Presence] in Serum or Plasma
890-4 (3001079)
Tremor, unspecified
R25.1 (45539327)
Basophils/Leukocytes in Blood
30180-4 (3022096)
Lymphocytes/Leukocytes in Blood
26478-8 (3002030)
Eosinophils/Leukocytes in Blood
26450-7 (3006504)
Monocytes/Leukocytes in Blood
26485-3 (3019069)
Neutrophils/Leukocytes in Blood
26511-6 (3018010)
Biopsy from other organ close to skin with ultrasound quidance
XW1AT (2001311084)
Scheduled procedure
ZXD10 (2001311387)
Case Management Agency
251B00000X (38004193)
Lymphocytes [#/volume] in Blood
26474-7 (3019198)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
Recording of ECG
SPAT1097 (2001700198)
Type 1 diabetes mellitus, Without complications
E10.9 (45581351)
Tissue transglutaminase IgA Ab [Units/volume] in Serum
31017-7 (3019050)
Differential panel, method unspecified - Blood
69738-3 (42870588)
General anesthesia, balanced
WX408 (2001310808)
hypromellose
S01KA02 (21605115)
Monocytes [#/volume] in Blood
26484-6 (3001604)
Basophils [#/volume] in Blood
26444-0 (3006315)
metoprolol; oral, parenteral
C07AB02 (21601684)
Emergency Room and Inpatient Visit
ERIP (262)
Bilateral
ZXA10 (2001311348)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
Cortisol [Moles/volume] in Serum or Plasma
14675-3 (3036481)
Other investigative procedure of eye
XCW99 (2001301491)
Bilirubin.total [Moles/volume] in Serum or Plasma
14631-6 (3006140)
Neuro-ophthalmology Physician
207WX0109X (903241)
Dry eye syndrome
H04.10 (2000502254)
Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability
16182-8 (3021952)
Extensive CT examination of arteria pulmonalis
FB1BD (2001302407)
Alkaline phosphatase.bone [Enzymatic activity/volume] in Serum or Plasma
1777-2 (3001467)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
FEV1/FVC
19926-5 (3011505)
Forced vital capacity [Volume] Respiratory system
19870-5 (3020158)
FEV1
20150-9 (3024653)
Reticulocytes/Erythrocytes in Blood
4679-7 (3027945)
retinol
S01XA02 (21605128)
Amylase [Enzymatic activity/volume] in Serum or Plasma
1798-8 (3016771)
Forced vital capacity [Volume] Respiratory system --post bronchodilation
19875-4 (3001668)
FEV1 --post bronchodilation
20155-8 (3023550)
FEV1/FVC --post bronchodilation
69970-2 (42868459)
FVC percent change Respiratory system
69982-7 (42868471)
FEV1 percent change
69983-5 (42868472)
Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
33762-6 (3029187)
Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
2324-2 (3026910)
Treatment plan or consultation
WZC00 (2001310885)
INR in Blood by Coagulation assay
34714-6 (3032080)
Speech therapy
Z50.5 (45547321)
Heart failure, unspecified
I50.9 (45576879)
Intravenous general anesthesia
WX404 (2001310807)
Asthma, unspecified
J45.9 (45562456)
More than one and less than three hours
ZXE10 (2001311401)
Cathetrisation of vein
TPH04 (2001309597)
Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
30248-9 (3015399)
rivaroxaban; oral
B01AF01 (43534761)
Other specified dysphonia
R49.08 (2000503601)
Neoplasm of uncertain or unknown behaviour: Thyroid gland
D44.0 (45605366)
General anaesthesia
WX402 (2001310806)
Examination of eyes and vision
Z01.0 (45566391)
Sleep apnoea
G47.3 (45562094)
Calcium [Moles/volume] corrected for albumin in Serum or Plasma
29265-6 (3020059)
Cardiology
6 (38004451)
Folate [Moles/volume] in Red Blood Cells
14731-4 (3019309)
Tissue Pathology biopsy report
66121-5 (40768804)
apixaban; oral
B01AF02 (43534762)
CBC W Ordered Manual Differential panel - Blood
57782-5 (40760892)
Neurology
13 (38004458)
Postprocedural hypothyroidism, other or several procedures
E89.09 (2000501555)
Iron/Transferrin [Ratio] in Serum or Plasma
60517-0 (40763571)
Malaise and fatigue
R53 (45553741)
zopiclone; oral
N05CF01 (21604654)
Thorax X-ray examination
GD1AA (2001303617)
Transferrin [Mass/volume] in Serum or Plasma
3034-6 (3004789)
Dyspnoea
R06.0 (45558449)
Bilirubin.conjugated [Moles/volume] in Serum or Plasma
29760-6 (3005772)
Inpatient Visit
IP (9201)
Recession of extraocular muscle
CEC00 (2001301083)
Iron [Moles/volume] in Serum or Plasma
14798-3 (3022948)
Microorganisms panel - Urine sediment
58435-9 (40761536)
Exophthalmic conditions
H05.2 (45571878)
Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
48065-7 (3051714)
One hour or less
ZXE00 (2001311394)
ABO and Rh group [Type] in Blood by Confirmatory method
77397-8 (46236098)
Cardiac arrhythmia, unspecified
I49.9 (45581778)
Obstetrics / Gynecology
16 (38004461)
Audiology
64 (38004489)
Shortness of breath/dyspnoea
R02 (2002000883)
Measurement of bone density from two or more locations with X-ray
NK6QA (2001308500)
Prothrombin time (PT) actual/Normal
5894-1 (3033658)
Holo-transcobalamin II [Moles/volume] in Serum
72160-5 (43054903)
Other visual field testing
CS494 (2001301478)
Teaching
WZC30 (2001310891)
pantoprazole; oral, parenteral
A02BC02 (21600097)
Telehealth
OMOP5556618 (722455)
Oedema, unspecified
R60.9 (45568143)
Magnesium [Moles/volume] in Serum or Plasma
2601-3 (3012095)
Blood type and Crossmatch panel - Blood
34531-4 (3044640)
Other disorders affecting eyelid function
H02.5 (45581540)
Immunohistochemistry procedure
117617002 (4035726)
Ferritin [Mass/volume] in Serum or Plasma
2276-4 (3001122)
Troponin I.cardiac [Mass/volume] in Serum or Plasma
10839-9 (3021337)
Other radiotherapy
WF099 (2001310707)
Fasting glucose [Moles/volume] in Serum or Plasma
14771-0 (3018251)
Person consulting for explanation of investigation findings
Z71.2 (45552100)
Hemoglobin A1c/Hemoglobin.total in Blood
4548-4 (3004410)
Sodium and Potassium panel [Moles/volume] - Serum or Plasma
34548-8 (3045783)
Vascular Surgery
77 (38004496)
Flexible laryngoscopy
UDQ12 (2001301827)
ABO and Rh group [Type] in Blood
882-1 (3003694)
calcium carbonate
A02AC01 (21600065)
calcium carbonate; oral
A12AA04 (21600863)
Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
2157-6 (3007220)
Calcium [Moles/time] in 24 hour Urine
14637-3 (3010838)
Phosphate [Moles/volume] in Serum or Plasma
14879-1 (3003458)
Folate [Moles/volume] in Serum or Plasma
14732-2 (3021960)
Physiotherapist
Z3226 (2001311560)
Infiltration anesthesia
WX110 (2001310767)
hydrocortisone
S01BA02 (21603619)
hydrocortisone
S01CB03 (21603666)
codeine and paracetamol
N02AJ06 (1123647)
ibuprofen
R02AX02 (1588667)
ibuprofen; oral, parenteral, rectal
M01AE01 (21603967)
paracetamol; oral, parenteral, rectal
N02BE01 (21604344)
cefalexin; oral
J01DB01 (21602870)
azithromycin; oral, parenteral
J01FA10 (21602978)
Cholesterol in HDL [Moles/volume] in Serum or Plasma
14646-4 (3023602)
Cholesterol [Moles/volume] in Serum or Plasma
14647-2 (3019900)
Cholesterol in LDL [Moles/volume] in Serum or Plasma
22748-8 (3001308)
Triglyceride [Moles/volume] in Serum or Plasma --fasting
47210-0 (3048773)
Exophoria
H50.52 (2000502357)
Hypothyroidism, unspecified
E03.9 (45537945)
Medical Oncology
90 (38004507)
Spinalanesthesia
WX320 (2001310799)
Postpartum check-up
SPAT1380 (2001700480)
Outcome of delivery
Z37 (45581024)
Intraoral radiographic dental examination
EB1AA (2001301903)
diclofenac; oral, parenteral, rectal
M01AB05 (21603945)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1628
3871
5.95
307.65
1.5
1.2
226.75
143.40
u/ml
8.51
894
1454
2980
1131
72.61
307.65
3.7
1.6
21.90
8.53
iu/l
0.56
2071
392
3121
3046
29.59
307.65
8.9
2.9
4.87
4.46
pmol/l
35.18
2989
2733
4523
34332
17.27
284.68
18.6
4.6
15.55
14.54
pmol/l
151.54
4426
32244
2991
19309
2.56
196.60
7.5
6.7
1.21
1.22
mmol/l
2.32
2589
16811
858
2992
3.29
191.77
2.8
3.6
52.73
81.20
ng/l
22.80
767
2593
2663
17133
2.31
163.57
6.3
6.1
1.21
1.22
mmol/l
0.43
2500
15953
2004
11718
2.26
151.54
4.9
4.0
7.40
7.40
ph
1.40
1506
8333
4541
39020
11.49
145.07
20.0
5.6
1.68
1.81
mu/l
5.11
4445
36941
3295
24027
2.30
138.43
10.1
9.7
3.68
3.99
e9/l
16.90
2866
21063
2158
14177
1.98
108.73
3.0
3.4
2.34
2.36
mmol/l
9.93
1995
13069
3765
30894
2.19
91.48
9.5
8.0
80.12
76.29
u/l
6.19
3636
29463
128
170
7.72
90.82
1.6
1.5
15.89
14.39
pmol/l
1.41
114
141
2661
20117
1.76
74.17
2.8
2.5
75.01
76.69
nmol/l
2.61
2479
18653
3673
30982
1.91
66.51
4.5
4.4
10.78
11.01
mm/h
0.56
3504
29360
192
509
3.89
63.38
4.4
4.9
89.78
83.38
u/ml
0.06
79
162
617
3072
2.16
62.03
2.3
1.7
—
—
—
0
0
127
300
4.32
48.98
5.3
7.2
40.10
84.26
ug/l
0.34
89
192
2559
20351
1.58
48.60
5.6
6.6
29.15
28.94
%
0.48
2400
19398
2751
22299
1.58
47.66
5.7
6.7
0.19
0.19
e9/l
0.12
2430
19776
1735
12680
1.59
47.04
7.2
6.2
—
—
—
0
0
2482
19726
1.56
46.28
5.7
6.7
0.65
0.70
%
3.91
2298
18561
4383
40571
2.61
46.08
16.3
15.2
139.80
139.70
mmol/l
2.39
4321
39802
4388
40664
2.62
45.55
16.6
15.4
3.93
3.93
mmol/l
0.73
4323
39815
2482
19768
1.55
45.52
5.7
6.7
8.74
8.49
%
4.15
2302
18666
1597
11513
1.59
45.51
1.4
1.3
2.02
1.59
u/ml
0.56
447
3325
2478
19742
1.55
45.28
5.6
6.6
2.83
2.82
%
0.06
2302
18604
2497
20026
1.54
43.53
5.4
6.5
55.98
56.63
%
2.17
2369
19212
2700
22070
1.54
42.78
5.5
6.5
1.90
1.95
e9/l
0.95
2405
19717
2648
21610
1.53
41.82
5.5
6.5
0.04
0.04
e9/l
6.21
2297
18831
2641
21568
1.53
41.36
5.5
6.5
0.55
0.55
e9/l
0.13
2298
18808
2291
18653
1.45
33.10
12.7
10.6
0.00
0.00
e9/l
0.30
1886
15226
4496
42848
2.94
31.56
15.1
11.4
24.61
25.02
u/l
1.00
4439
41872
1330
9817
1.50
31.36
1.5
1.5
2.17
2.24
g/l
0.84
807
6277
2714
22947
1.44
31.19
4.5
4.7
6.51
6.47
mmol/l
0.47
2550
21448
4329
40728
2.02
29.27
14.5
14.1
19.58
21.14
mg/l
2.61
3583
33191
562
3527
1.68
26.30
4.6
3.9
7.38
7.35
ph
8.35
451
2520
667
4386
1.61
25.91
2.1
2.3
371.73
374.17
nmol/l
0.12
619
4078
4480
42938
2.50
25.21
18.9
17.2
69.25
70.62
umol/l
3.68
4439
42490
488
3009
1.70
24.33
3.9
3.6
1.22
1.23
mmol/l
2.61
426
2612
4034
37545
1.59
23.61
6.2
5.6
38.76
38.17
mmol/mol
3.51
3802
35653
2623
22714
1.36
22.19
3.5
3.2
95.07
91.73
ug/l
0.37
2465
21553
4118
38645
1.61
21.75
4.9
4.6
5.81
5.76
mmol/l
1.62
3857
36208
2076
17527
1.34
19.87
4.3
4.8
36.59
36.41
g/l
0.88
1936
16532
1658
13590
1.34
19.20
2.2
2.3
—
—
—
0
0
684
4846
1.48
18.48
4.0
5.6
1.07
1.04
mmol/l
2.26
644
4494
2421
21057
1.32
18.10
5.7
6.4
10.45
10.37
umol/l
0.15
2290
20065
856
6352
1.43
18.08
2.9
3.4
0.80
0.82
mmol/l
5.19
809
5997
1531
12492
1.34
17.98
3.4
3.2
1.00
0.74
—
5
27
3773
35061
1.42
17.95
22.3
17.1
13.45
13.48
%
0.94
3731
34614
572
3955
1.51
17.35
1.2
1.2
—
—
—
0
0
1012
7789
1.38
17.18
2.7
2.8
2.43
2.44
mmol/l
1.72
888
7018
4556
44471
2.98
16.40
28.4
21.5
90.30
90.72
fl
9.31
4537
44131
4556
44471
2.98
16.40
28.4
21.4
30.02
30.18
pg
7.96
4537
44132
4556
44474
2.98
16.34
28.8
21.9
40.60
40.70
%
0.17
4534
44109
4556
44477
2.97
16.28
28.5
21.5
4.54
4.47
e12/l
21.18
4497
43682
4555
44463
2.94
16.27
28.5
21.6
263.76
262.78
e9/l
0.53
4509
43761
4556
44480
2.97
16.22
28.6
21.6
6.48
6.65
e9/l
5.00
4497
43670
166
831
2.03
16.09
2.0
2.0
5.03
5.26
mmol/24h
0.42
147
747
4556
44487
2.95
16.09
28.7
21.7
135.45
134.09
g/l
12.01
4538
44148
1190
9520
1.34
15.51
3.1
3.0
927.19
952.58
ng/l
0.10
986
8032
1268
10240
1.33
15.48
2.1
2.2
—
—
—
0
0
2269
19805
1.29
15.45
2.6
2.7
—
—
estimate
—
0
0
1320
10733
1.32
15.33
2.3
2.3
2.57
2.71
mg/l
1.59
1153
9365
1653
13870
1.30
15.21
3.4
3.3
47.03
83.99
ng/l
0.42
938
8092
1989
17139
1.28
14.74
2.1
2.0
96.92
98.67
pmol/l
0.91
1089
8939
2043
17922
1.25
12.19
2.1
2.1
—
—
—
0
0
1877
16314
1.25
12.14
11.5
11.0
1.17
1.16
inr
0.62
1584
13420
1247
10345
1.28
11.86
3.9
4.6
—
—
—
0
0
861
6915
1.30
10.34
1.4
1.4
501.11
553.08
titre
0.44
216
1485
63
255
2.49
10.31
1.9
1.6
101.38
91.08
ng/l
0.13
63
255
3187
29709
1.24
9.63
3.4
3.2
40.88
40.36
u/l
0.13
3042
28295
1168
9816
1.25
9.62
2.0
1.8
0.80
1.03
mg/l
4.11
900
7542
707
5586
1.31
9.52
3.0
3.1
4.27
4.39
e9/l
0.13
620
4967
4172
40284
1.37
8.96
5.0
4.7
4.73
4.80
mmol/l
5.51
3937
38321
1488
12924
1.22
8.90
2.6
2.7
71.56
65.29
u/l
0.15
1365
12048
4154
40118
1.36
8.60
4.9
4.6
1.50
1.53
mmol/l
3.33
3907
37974
452
3399
1.37
8.47
3.8
3.7
—
—
—
0
0
759
6141
1.28
8.47
2.3
2.5
2.43
2.40
g/l
0.70
695
5701
4204
40700
1.37
8.36
5.6
5.3
2.81
2.83
mmol/l
0.98
3953
38562
1953
17498
1.20
8.31
2.0
1.9
1.32
1.36
mmol/l
1.55
1629
15109
808
6690
1.25
7.36
2.3
2.5
13.87
13.74
umol/l
0.20
745
6263
333
2449
1.39
7.17
1.1
1.1
91.82
163.93
titre
0.81
17
70
1026
8750
1.22
7.07
1.3
1.3
6.04
9.61
u/ml
1.54
388
3614
481
3757
1.31
6.97
1.5
1.4
27.34
28.18
iu/l
0.23
414
3260
837
7001
1.24
6.93
3.8
3.5
122.08
387.07
ng/l
4.68
565
4671
227
1570
1.47
6.88
1.3
1.3
54.00
32.51
u/ml
—
9
98
3949
38087
1.26
6.71
4.1
4.0
1.22
1.25
mmol/l
1.91
3683
35792
1098
9491
1.21
6.53
1.4
1.3
26.68
28.84
iu/ml
0.19
315
2939
5
288
0.17
6.47
18.8
15.2
734.00
5358.07
nmol/l
—
5
277
205
1409
1.48
6.43
1.3
1.3
—
—
—
0
0
675
5572
1.25
6.26
2.4
2.5
22.48
23.02
%
0.54
621
5180
1459
12979
1.18
6.23
1.6
1.6
—
—
—
0
0
6
298
0.20
6.22
19.3
20.6
1171.50
4669.02
nmol/l
—
6
288
699
5798
1.24
6.21
1.7
1.7
1074.92
1182.41
nmol/l
2.79
549
4470
478
3818
1.28
5.85
2.4
2.7
1.69
1.77
%
1.07
432
3417
205
1445
1.44
5.68
1.3
1.3
29.00
7.56
u/ml
0.69
22
227
848
7241
1.21
5.65
2.8
2.8
511.48
516.60
mosm/kgh2o
0.28
735
6330
1326
11798
1.17
5.52
2.1
2.1
207.52
179.52
u/l
0.20
1253
11227
27
99
2.74
5.52
1.2
1.2
6.71
11.03
pmol/l
—
8
31
204
1446
1.43
5.50
1.3
1.3
2.44
5.14
u/ml
0.61
12
145
705
5933
1.22
5.43
1.3
1.2
—
—
—
0
0
1166
10278
1.18
5.42
3.9
3.8
93.01
95.12
%
2.36
1139
10033
57
294
1.95
5.34
1.1
1.1
5.30
5.47
nmol/l
—
6
51
1404
12578
1.17
5.33
3.4
3.1
0.16
0.11
estimate
0.12
435
3753
590
4898
1.23
5.18
2.7
2.6
5.77
6.77
umol/l
1.37
505
4238
188
1329
1.43
5.16
1.1
1.1
5.25
6.44
eliau/ml
0.21
33
194
221
1611
1.39
5.10
1.4
1.5
11.66
11.23
iu/ml
—
5
43
2890
27337
1.15
5.08
4.7
4.5
2323.76
2010.39
e6/l
0.08
41
319
306
2352
1.32
5.02
3.3
2.9
141.72
155.37
ng/l
0.42
269
2126
174
1220
1.44
5.00
1.2
1.3
47.99
36.54
u/ml
0.40
19
124
1205
10730
1.17
4.87
1.6
1.7
20.12
20.64
nmol/l
0.65
1035
9273
439
3574
1.25
4.60
3.5
4.9
0.05
0.30
%
1.06
84
822
107
694
1.55
4.52
1.1
1.1
205.14
16373.25
iu/ml
0.60
25
159
180
1308
1.39
4.29
1.3
1.2
127.27
152.96
titre
0.22
22
125
94
602
1.57
4.22
1.3
1.3
—
—
—
0
0
427
3501
1.24
4.22
3.6
4.7
0.09
0.12
%
0.33
86
857
918
8097
1.17
4.12
1.6
1.7
62225524.03
35296250.89
pmol/l
0.56
773
6930
91
585
1.57
4.04
2.2
1.5
62.18
57.73
mu/l
0.13
81
533
351
2832
1.26
4.01
2.2
2.7
73.89
71.06
e9/l
0.60
256
2041
1591
14619
1.13
3.96
3.2
3.2
29.28
30.93
u/l
0.83
1522
13894
439
3644
1.23
3.88
3.6
4.7
1.01
0.92
%
0.16
95
1002
84
542
1.56
3.70
1.2
1.3
0.17
0.21
nmol/l
0.66
66
414
277
2199
1.28
3.64
3.0
3.4
5.22
5.16
kpa
0.46
267
2124
1371
12535
1.13
3.63
3.4
3.2
25.34
73.62
e6/l
3.31
1035
9418
94
626
1.51
3.60
1.3
1.3
0.59
3.40
nmol/l
0.50
94
606
178
1332
1.35
3.59
2.2
2.3
2.82
2.88
g/l
0.47
164
1232
195
1481
1.33
3.57
1.5
2.0
0.24
0.23
g/l
0.54
185
1405
268
2125
1.28
3.56
2.9
3.5
7.41
7.42
ph
0.99
216
1777
747
6568
1.16
3.47
2.0
2.4
105.71
113.29
ug/g
0.23
583
5224
1193
10865
1.13
3.32
3.3
3.0
0.30
0.37
e6/l
0.79
861
7838
559
4830
1.18
3.23
1.3
1.4
—
—
—
0
0
95
650
1.47
3.23
1.3
1.3
0.36
0.41
nmol/l
—
7
23
529
4550
1.18
3.23
4.9
4.5
32.79
32.51
%
0.25
372
3176
1614
15008
1.12
3.12
4.0
3.8
60.50
86.26
e6/l
1.40
1115
10173
413
3487
1.20
3.11
3.4
4.5
0.84
0.69
%
0.43
90
961
260
2095
1.26
3.07
1.7
2.0
4.24
6.99
iu/ml
1.98
44
509
403
3400
1.20
3.06
2.2
2.9
10.28
10.50
g/l
0.55
369
3161
182
1405
1.31
3.02
2.4
2.2
3.66
3.69
g/l
0.10
167
1307
2359
22410
1.11
3.01
3.8
3.8
0.00
0.00
estimate
1.84
519
4618
182
1407
1.31
2.99
2.5
2.2
4.27
4.30
g/l
0.13
168
1306
182
1408
1.30
2.98
2.5
2.2
7.38
7.37
g/l
0.04
167
1307
1911
17973
1.11
2.94
2.9
2.8
—
—
—
0
0
42
242
1.74
2.93
1.1
1.1
—
21.00
u/ml
—
0
26
195
1529
1.29
2.89
1.5
1.9
1.23
1.18
g/l
1.31
184
1455
2376
22624
1.10
2.82
3.8
3.8
2.85
4.55
estimate
0.23
528
4718
119
873
1.37
2.80
2.0
2.2
5.27
4.74
umol/l
0.25
82
640
184
1441
1.29
2.77
1.5
1.3
11.20
12.24
u/l
0.46
151
1200
1257
11605
1.11
2.71
4.5
4.1
6.05
8.55
mg/mmol
1.49
751
6943
952
8663
1.12
2.64
2.8
2.6
6.99
7.22
e6/l
0.16
859
7854
187
1480
1.27
2.61
2.8
3.5
—
—
—
0
0
641
5693
1.15
2.60
1.2
1.3
—
—
—
0
0
2387
22795
1.10
2.57
3.8
3.8
0.11
0.09
estimate
0.07
514
4523
1383
12864
1.11
2.57
3.5
3.4
7.37
7.33
mmol/l
0.13
1185
11072
5
7
7.15
2.55
1.0
1.0
—
—
—
0
0
101
736
1.38
2.51
1.1
1.1
2.98
3.84
eliau/ml
0.35
51
364
1237
11463
1.11
2.46
3.7
3.4
33.46
44.66
mg/l
1.38
757
6923
137
1050
1.31
2.46
2.9
2.9
1.66
2.13
index
0.56
64
546
41
248
1.66
2.46
1.9
1.7
5.61
3.99
nmol/l
0.17
36
185
78
547
1.43
2.42
1.4
1.4
271.97
379.20
pmol/l
1.33
65
479
333
2828
1.19
2.41
2.4
2.7
65.93
67.02
g/l
1.89
306
2619
94
1273
0.73
2.35
9.7
8.8
—
—
—
0
0
150
1173
1.29
2.34
2.1
2.2
10.93
11.43
mg/l
0.34
141
1104
101
747
1.36
2.32
3.5
3.4
—
—
—
0
0
36
214
1.69
2.31
1.7
2.2
2075.03
1936.08
ml
0.36
30
198
677
6085
1.13
2.30
3.0
2.8
3.85
3.76
e6/l
0.07
341
2816
149
1168
1.28
2.28
2.4
3.6
24.83
24.95
mmol/l
0.18
137
1083
157
1239
1.28
2.28
1.5
1.4
292.51
298.35
ug/g
0.13
100
662
151
1186
1.28
2.28
2.6
2.2
9.55
10.20
g/l
1.54
136
1076
88
639
1.38
2.27
1.2
1.3
49.98
60.52
u/ml
—
5
41
214
1766
1.22
2.12
2.3
2.2
11.23
11.28
nmol/l
0.03
195
1599
462
4072
1.15
2.12
2.8
2.4
40.07
49.87
u/l
0.34
389
3412
387
3367
1.16
2.12
2.8
3.6
5.87
5.82
kpa
0.54
369
3273
1099
10198
1.10
2.10
2.4
2.4
313.39
317.44
umol/l
0.77
971
9186
102
770
1.33
2.08
1.6
1.6
0.79
0.68
g/l
0.48
74
605
70
497
1.41
2.08
4.0
3.5
0.76
0.79
nmol/l
0.39
59
409
400
3496
1.16
2.07
2.7
2.5
6.11
6.13
ph
0.20
271
2232
23
124
1.86
2.06
1.0
1.2
—
—
—
0
0
1360
12769
1.09
2.01
2.8
2.9
0.06
0.05
0.07
17
237
58
403
1.44
1.95
1.3
1.2
0.98
1.35
u/ml
0.19
29
206
374
3271
1.16
1.93
2.8
3.6
1.78
1.85
mmol/l
0.13
312
2866
9
33
2.73
1.93
2.7
2.0
—
—
—
0
0
400
3517
1.15
1.92
1.5
1.6
952.39
1008.73
mu/l
0.58
319
2933
35
545
0.64
1.91
6.3
6.0
368.67
371.31
umol/l
0.04
29
475
399
3513
1.15
1.88
1.4
1.4
—
—
—
0
0
370
3243
1.15
1.86
1.2
1.3
—
—
—
0
0
685
6243
1.11
1.86
1.5
1.5
—
—
—
0
0
33
205
1.61
1.85
1.2
1.4
156.42
152.38
mmol/24h
0.13
33
205
122
965
1.27
1.81
2.5
3.3
57.96
57.43
%
0.19
122
965
87
658
1.33
1.80
1.4
1.4
69.69
63.05
mmol/l
0.62
67
532
171
1407
1.22
1.79
1.3
1.3
—
—
—
0
0
131
1047
1.26
1.79
1.3
1.3
30.16
27.60
u/l
0.36
106
860
51
355
1.44
1.73
2.1
2.1
18.64
19.38
nmol/l
0.24
46
339
477
4288
1.13
1.66
5.2
4.8
2.03
2.21
ug/l
0.25
413
3890
46
317
1.46
1.66
1.1
1.1
1.07
1.05
ratio
0.77
33
257
415
3700
1.13
1.65
2.2
2.3
0.21
0.22
g/l
0.46
387
3491
65
480
1.36
1.60
1.4
1.4
6.18
6.67
g/l
0.72
44
350
65
480
1.36
1.60
1.4
1.4
0.34
0.39
g/l
0.75
43
347
65
480
1.36
1.60
1.4
1.4
2.82
2.95
g/l
0.30
44
350
451
5010
0.89
1.60
1.3
1.3
—
—
—
0
0
382
3396
1.14
1.60
2.9
3.6
7.38
7.38
ph
0.02
216
1896
388
3453
1.14
1.60
1.4
1.3
142.86
206.47
u/ml
1.26
368
3231
56
405
1.39
1.57
1.2
1.2
116.61
112.49
pmol/l
0.27
56
405
58
422
1.38
1.57
1.2
1.2
—
—
—
0
0
176
1477
1.20
1.55
1.8
1.8
1.45
1.50
g/l
0.34
147
1285
90
701
1.29
1.55
1.4
1.6
436.46
367.98
mu/l
0.45
71
559
253
2191
1.16
1.54
1.5
1.7
272.74
294.60
mu/l
0.71
215
1964
115
924
1.25
1.54
1.8
1.7
7490.96
8711.83
e6/l
0.19
72
646
133
1088
1.23
1.52
1.8
1.9
—
—
—
0
0
304
2672
1.15
1.52
1.6
1.9
1.11
1.33
g/l
3.62
283
2484
378
3371
1.13
1.52
2.4
2.4
15.81
20.45
au/ml
1.08
42
430
0
43
0.00
1.52
0.0
1.3
—
108.60
—
0
8
1275
12068
1.08
1.51
3.9
3.9
0.00
0.00
estimate
2.60
501
4402
57
417
1.37
1.50
2.2
2.1
29.70
24.18
mg/l
0.30
27
162
63
469
1.35
1.49
1.4
1.4
—
—
—
0
0
5
126
0.40
1.49
3.0
2.1
8.66
16.21
umol/l
—
5
126
44
308
1.43
1.49
1.3
1.2
—
—
—
0
0
28
178
1.58
1.48
3.0
3.1
—
—
—
0
0
29
186
1.56
1.48
1.3
1.3
—
—
—
0
0
947
8883
1.08
1.41
1.7
1.7
—
—
—
0
0
316
2802
1.14
1.41
2.2
2.2
5755.93
5654.39
u/l
0.02
131
1134
147
1227
1.20
1.40
1.9
2.3
206.34
577.22
ug/l
1.36
135
1148
97
777
1.25
1.37
1.1
1.1
—
—
—
0
0
236
2062
1.15
1.32
1.3
1.3
0.47
1.35
u/ml
1.69
17
161
46
334
1.38
1.30
2.9
2.6
23.31
26.65
mg/l
0.31
36
231
1785
17170
1.06
1.30
3.7
3.6
1.19
0.21
estimate
0.40
433
3812
52
386
1.35
1.29
1.2
1.2
—
—
—
0
0
19
114
1.67
1.28
1.1
1.1
—
—
—
0
0
69
882
0.78
1.27
2.3
3.9
3.78
3.82
mmol/l
0.36
69
875
86
691
1.25
1.21
3.3
3.6
2.43
2.52
mmol/l
0.12
58
456
229
2015
1.14
1.18
1.1
1.1
—
—
—
0
0
46
341
1.35
1.17
1.2
1.2
230.00
210.75
titre
—
8
67
29
198
1.47
1.16
3.0
3.0
—
—
—
0
0
1318
12602
1.06
1.14
3.0
3.0
—
—
—
0
0
27
183
1.48
1.13
2.6
2.4
16.19
16.33
%
0.09
27
183
87
1064
0.81
1.12
2.3
3.7
1.24
1.37
mmol/l
0.78
87
1049
73
582
1.26
1.12
1.1
1.1
1.50
1.49
g/l
0.06
67
525
102
844
1.21
1.11
2.0
2.3
132.73
129.71
g/l
0.72
80
674
88
717
1.23
1.11
2.6
2.6
52.60
83.49
ug/min
0.63
62
434
214
1886
1.14
1.10
2.9
3.2
1.02
1.02
ratio
0.79
191
1686
124
1048
1.19
1.09
3.4
3.5
38.25
51.41
mg/l
0.87
104
904
345
3131
1.11
1.09
1.3
1.3
49.59
47.11
au/ml
0.07
17
204
135
1576
0.85
1.06
1.8
2.8
—
—
—
0
0
421
3865
1.10
1.06
6.4
7.9
5.11
5.08
kpa
0.18
406
3721
421
3865
1.10
1.06
6.4
7.9
13.02
12.95
kpa
0.08
404
3720
431
3965
1.10
1.04
1.4
1.5
—
—
—
0
0
30
417
0.72
1.03
2.3
2.5
1.19
1.14
g/24h
0.07
17
246
85
699
1.22
1.01
2.5
2.5
17.00
16.52
%
0.84
85
687
585
5463
1.08
1.01
2.1
2.0
—
—
—
0
0
117
993
1.18
1.00
1.4
1.4
2.23
3.79
ug/l
2.82
107
893
44
334
1.32
1.00
3.1
2.8
—
—
—
0
0
123
1049
1.18
1.00
3.4
3.5
33.30
52.68
mg/l
0.97
103
905
20
131
1.53
0.99
1.2
1.3
7.44
7.40
ph
0.38
15
84
27
189
1.43
0.98
2.4
3.0
—
—
—
0
0
213
1895
1.13
0.97
7.8
10.5
16.38
15.97
%
1.38
205
1821
10
54
1.85
0.96
1.7
1.3
—
—
—
0
0
60
746
0.80
0.94
2.2
2.9
35.77
33.80
umol/l
0.18
53
690
14
85
1.65
0.94
1.1
1.1
10.36
6.75
u/ml
0.39
14
85
11
62
1.78
0.94
2.0
1.9
—
—
—
0
0
36
268
1.35
0.94
1.2
1.2
9.61
9.76
mm/h
0.03
36
268
169
1913
0.88
0.91
1.1
1.1
0.59
0.63
ratio
0.40
18
223
218
1953
1.12
0.91
1.9
1.9
—
—
—
0
0
117
1005
1.17
0.89
1.7
1.3
15.57
28.63
e6/l
0.73
88
730
109
931
1.17
0.89
3.5
3.2
1.24
2.92
ratio
2.33
59
527
6
29
2.07
0.89
1.0
1.1
—
—
—
0
0
29
211
1.38
0.88
1.7
2.6
157.57
175.32
umol/l
0.09
14
112
368
3395
1.09
0.87
6.7
8.4
95.79
95.95
%
0.21
352
3288
39
298
1.31
0.87
1.5
1.6
6.34
6.17
mmol/l
0.18
30
223
60
485
1.24
0.87
2.2
1.5
—
—
—
0
0
146
1279
1.15
0.87
3.2
3.6
110.14
1358.42
u/ml
0.95
122
1097
326
2992
1.10
0.87
7.4
8.7
—
—
—
0
0
6
30
2.00
0.87
1.5
1.1
—
—
—
0
0
413
3834
1.08
0.85
6.5
8.0
0.80
0.92
mmol/l
0.24
338
3139
6
31
1.94
0.84
1.2
1.4
0.16
0.16
umol/l
—
6
31
282
2576
1.10
0.83
1.2
1.2
—
—
—
0
0
46
363
1.27
0.82
1.0
1.0
0.86
1.80
u/ml
0.39
14
113
40
310
1.29
0.82
1.2
1.1
—
—
—
0
0
45
356
1.27
0.79
9.7
5.5
7.26
7.10
mmol/l
0.09
35
308
0
25
0.00
0.79
0.0
1.4
—
39.76
—
0
25
283
2599
1.09
0.77
2.9
3.0
0.68
0.72
ug/l
0.56
165
1525
46
367
1.26
0.77
1.0
1.1
—
—
—
0
0
117
1021
1.15
0.76
1.8
1.4
755.25
1355.35
e6/l
0.66
92
791
208
1882
1.11
0.76
1.5
1.6
11.95
12.52
u/ml
0.06
45
511
414
3866
1.08
0.76
6.5
8.0
7.42
7.42
ph
0.68
214
2097
180
1616
1.12
0.76
1.2
1.2
—
—
—
0
0
9
53
1.70
0.75
4.7
7.0
0.13
0.18
%
—
9
53
14
92
1.52
0.72
1.0
1.0
72.73
76.83
ug/l
—
8
79
7
40
1.75
0.71
5.3
2.9
30.29
21.78
mg/l
—
7
40
53
435
1.22
0.70
1.4
1.6
48.65
53.95
%
0.44
37
263
5
26
1.92
0.70
1.0
1.1
—
—
—
0
0
959
9969
0.95
0.69
3.7
3.9
1.02
1.32
kg/l
0.80
678
6578
324
3011
1.08
0.69
2.4
2.4
0.28
0.42
e6/l
1.13
305
2838
989
9520
1.05
0.68
3.9
4.1
—
—
—
0
0
7
117
0.60
0.67
1.1
1.2
—
—
—
0
0
182
2006
0.90
0.67
1.4
1.3
231.88
229.98
miu/ml
0.02
98
989
509
4813
1.06
0.67
1.9
1.7
—
—
—
0
0
338
3152
1.08
0.66
6.5
7.5
1.29
1.27
mmol/l
0.10
327
3096
276
2554
1.09
0.66
2.0
2.2
5.50
6.55
ug/l
0.68
233
2269
706
6746
1.05
0.66
2.9
2.7
1.12
1.24
e6/l
0.24
372
3482
120
1063
1.13
0.66
1.1
1.1
—
—
—
0
0
88
763
1.16
0.65
1.2
1.2
—
—
—
0
0
17
120
1.42
0.64
2.5
2.7
—
—
—
0
0
127
1132
1.13
0.63
1.7
1.4
0.50
0.43
nmol/l
0.55
97
887
139
1247
1.12
0.63
1.5
1.5
69.49
60.65
ug/l
1.14
139
1247
208
1907
1.10
0.62
2.4
2.3
—
—
—
0
0
71
610
1.17
0.60
2.5
2.3
—
—
—
0
0
51
427
1.20
0.58
2.1
2.7
—
—
—
0
0
1851
18114
1.04
0.58
3.2
3.4
6.16
6.23
ph
1.83
1089
10400
0
23
0.00
0.58
0.0
1.0
—
0.03
—
0
10
11
162
0.68
0.58
2.6
2.5
111.36
154.67
nmol/l
1.01
11
145
342
3211
1.07
0.58
7.2
8.8
121.96
120.94
g/l
0.40
332
3139
393
3709
1.07
0.57
3.4
4.2
11.95
30.15
ug/l
0.99
300
2874
329
3087
1.07
0.57
3.4
3.4
48.54
51.27
u/ml
0.07
317
2991
53
448
1.19
0.56
1.4
1.5
274.83
278.69
mosm/kgh2o
0.58
36
353
40
329
1.22
0.55
1.4
1.6
35.08
37.13
%
0.11
26
188
8
123
0.65
0.54
5.9
5.0
—
—
—
0
0
6
38
1.58
0.54
1.3
2.7
22.17
16.74
mg/mmol
—
6
32
609
5835
1.05
0.53
1.5
1.6
—
—
—
0
0
9
63
1.43
0.52
1.3
2.0
5.04
654006.16
nmol/l
—
9
50
19
144
1.32
0.50
1.6
1.7
40.02
40.87
g/l
0.27
19
144
76
860
0.88
0.49
1.0
1.1
1.38
3.95
u/ml
2.03
33
367
22
279
0.79
0.48
1.2
1.2
—
—
—
0
0
205
1907
1.08
0.48
1.4
1.5
1.06
1.16
ratio
1.02
119
1148
16
211
0.76
0.47
1.3
1.3
219.63
286.40
u/l
0.45
16
194
81
720
1.13
0.47
1.2
1.2
—
—
—
0
0
137
1254
1.10
0.47
1.1
1.1
—
—
—
0
0
11
154
0.71
0.47
2.0
1.6
—
—
—
0
0
48
411
1.17
0.46
1.4
1.4
26.28
33.73
nmol/l
1.15
41
372
82
731
1.12
0.46
3.7
4.1
—
—
—
0
0
218
2038
1.07
0.45
1.4
1.5
59.86
59.87
ug/l
0.00
174
1692
156
1439
1.09
0.45
2.7
3.0
25.51
25.36
mmol/l
0.22
146
1379
36
301
1.20
0.45
2.6
3.0
18.35
46.66
mg/l
0.69
23
218
13
175
0.74
0.44
1.6
2.1
26.00
30.26
%
0.54
13
175
7
51
1.37
0.44
1.7
1.5
—
—
—
0
0
25
307
0.81
0.43
1.8
1.7
2.75
3.60
mg/l
0.92
25
299
22
274
0.80
0.43
3.0
2.0
2.73
1.83
u/field
0.48
11
147
135
1242
1.09
0.42
2.9
3.3
1503.81
404.89
mg/l
0.43
62
518
113
1031
1.10
0.42
4.3
6.6
1.21
1.23
mmol/l
0.11
98
906
11
151
0.73
0.42
1.3
1.1
—
—
—
0
0
224
2103
1.07
0.42
2.7
3.0
132.75
129.26
g/l
1.63
215
2039
174
1620
1.08
0.42
2.1
2.0
21.11
20.65
s
0.27
148
1396
85
765
1.11
0.42
3.0
2.4
0.91
0.88
nmol/l
0.12
66
664
24
294
0.82
0.41
1.0
1.1
1476.50
1521.71
miu/ml
0.07
24
294
0
16
0.00
0.41
0.0
8.1
—
108.31
—
0
16
0
17
0.00
0.40
0.0
2.8
—
—
—
0
0
215
2022
1.07
0.40
2.8
3.9
24.36
24.33
mmol/l
0.05
215
2003
27
223
1.21
0.39
2.1
2.8
41.91
45.72
%
0.58
14
126
46
401
1.15
0.38
1.9
1.7
89.49
90.19
%
0.23
46
396
8
113
0.71
0.37
1.1
1.1
—
—
—
0
0
47
535
0.88
0.36
2.4
2.3
—
—
—
0
0
22
180
1.22
0.35
1.7
1.4
128.32
238.62
nmol/24h
0.31
22
180
110
1015
1.09
0.35
1.0
1.1
—
—
—
0
0
15
117
1.28
0.35
4.5
3.3
53.33
115.65
ng/l
—
7
53
1006
10290
0.97
0.35
3.4
3.7
0.00
0.20
—
8
93
652
6331
1.03
0.34
1.7
1.8
—
—
—
0
0
40
458
0.87
0.34
2.5
2.9
—
—
—
0
0
6
44
1.36
0.34
2.2
2.1
40.28
56.58
pmol/l
—
6
37
84
919
0.91
0.34
1.0
1.1
3.34
3.58
u/ml
0.06
36
437
87
949
0.92
0.33
1.8
2.8
—
—
—
0
0
6
46
1.30
0.33
1.3
1.1
144.00
78.61
titre
—
6
46
136
1271
1.07
0.32
1.3
1.3
—
—
—
0
0
41
360
1.14
0.32
3.4
3.1
16.07
13.76
index
0.38
29
224
71
780
0.91
0.32
1.0
1.1
0.25
0.35
u/ml
0.19
26
238
18
146
1.23
0.32
13.7
5.1
93.69
63.58
mg/l
0.91
13
106
93
857
1.09
0.31
1.2
1.4
161.48
154.11
au/ml
0.23
25
244
22
183
1.20
0.31
1.5
1.6
0.53
0.49
e9/l
0.27
22
183
7
54
1.30
0.30
2.4
1.1
—
—
—
0
0
109
1014
1.08
0.30
1.0
1.1
—
—
—
0
0
41
362
1.13
0.30
1.2
1.4
1.40
1.44
nmol/l
0.09
36
326
103
958
1.08
0.29
1.7
1.3
—
—
—
0
0
8
106
0.75
0.29
1.0
1.2
—
—
—
0
0
8
111
0.72
0.28
1.6
2.0
—
—
—
0
0
26
302
0.86
0.28
2.2
2.0
—
—
—
0
0
154
1455
1.06
0.28
4.3
5.4
1.74
1.60
%
0.68
145
1372
29
252
1.15
0.27
1.8
1.8
1.62
1.75
u/ml
—
8
70
55
499
1.10
0.27
2.5
2.4
13.51
546.97
u/ml
0.53
55
494
64
586
1.09
0.26
1.2
1.3
35.29
25.77
u/l
0.18
59
507
17
203
0.84
0.25
1.8
1.7
5696.00
3437.33
titre
—
5
30
168
1765
0.95
0.25
2.5
2.9
0.63
0.62
%
0.33
168
1755
84
781
1.08
0.25
3.6
3.4
20.31
23.29
mg/l
0.40
54
537
36
403
0.89
0.24
1.2
1.4
—
—
—
0
0
429
4414
0.97
0.24
1.6
1.6
3.52
3.51
mmol/l
0.09
290
2978
33
371
0.89
0.24
1.7
2.2
41.65
40.72
%
0.14
33
365
9
77
1.17
0.24
1.8
1.3
—
143.80
—
0
10
37
331
1.12
0.24
2.6
2.0
20.95
23.44
ug/l
0.14
37
325
15
124
1.21
0.24
1.1
1.1
—
—
—
0
0
15
124
1.21
0.24
1.1
1.1
—
—
—
0
0
15
124
1.21
0.24
1.1
1.1
—
—
—
0
0
36
322
1.12
0.23
1.3
1.4
1835.43
2546.73
e6/l
0.59
28
215
45
408
1.10
0.23
1.8
2.3
32.02
32.00
pg
0.01
45
408
33
294
1.12
0.23
1.6
1.5
4.83
5.51
u/l
1.03
24
259
40
361
1.11
0.23
2.3
2.7
11.38
10.43
mmol/l
0.95
40
356
71
763
0.93
0.22
1.3
1.2
3.41
3.93
u/ml
0.25
41
319
99
933
1.06
0.22
1.2
1.4
—
—
—
0
0
34
305
1.12
0.21
1.4
1.2
0.78
0.63
ratio
0.35
21
193
83
778
1.07
0.21
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
33.37
—
0
11
0
11
0.00
0.21
0.0
1.0
—
9943.73
—
0
11
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
71.51
—
0
10
289
2799
1.03
0.21
2.6
3.1
4.55
4.56
kpa
0.02
275
2719
0
12
0.00
0.21
0.0
1.0
—
2.23
—
0
7
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
4.38
—
0
12
0
13
0.00
0.21
0.0
1.0
—
0.18
—
0
7
11
134
0.82
0.20
1.5
1.5
10.08
8.63
ug/l
0.32
11
134
0
14
0.00
0.20
0.0
4.7
—
3.09
—
0
9
9
111
0.81
0.20
1.1
1.2
—
—
—
0
0
9
113
0.80
0.20
1.0
1.0
—
—
—
0
0
39
355
1.10
0.20
1.3
1.4
32.74
34.25
g/l
0.32
34
326
18
156
1.15
0.18
2.1
2.2
1.71
2.73
ug/l
1.01
13
136
122
1165
1.05
0.18
1.4
1.3
467.07
486.67
mg/l
0.22
115
1122
98
931
1.05
0.18
1.1
1.1
10.93
15.58
au/ml
0.37
29
248
166
1723
0.96
0.17
1.6
2.1
—
—
—
0
0
127
1216
1.05
0.17
1.2
1.1
—
—
—
0
0
36
393
0.92
0.17
1.1
1.2
—
—
—
0
0
10
82
1.22
0.17
1.1
1.3
56.00
63.89
ug/l
—
10
82
5
67
0.75
0.17
7.0
7.1
6.96
5.36
kpa
—
5
67
524
5145
1.02
0.16
1.5
1.5
—
—
—
0
0
543
5527
0.98
0.16
2.3
2.1
30.00
29.17
s
2.24
521
5373
14
162
0.86
0.16
3.4
1.5
—
—
—
0
0
15
130
1.15
0.15
1.1
1.1
25.81
38.70
iu/ml
0.59
15
130
17
149
1.14
0.15
1.0
1.1
0.07
1.80
u/ml
—
6
80
6
78
0.77
0.15
1.2
1.1
—
—
—
0
0
60
565
1.06
0.15
3.1
3.2
1.08
1.50
%
0.92
51
516
31
338
0.92
0.15
1.5
1.4
—
—
—
0
0
43
400
1.08
0.15
1.1
1.1
16.32
15.85
u/ml
0.05
23
186
19
169
1.12
0.14
2.7
1.9
—
—
—
0
0
181
1865
0.97
0.14
1.3
1.6
0.23
0.30
mg/l
1.38
77
820
13
149
0.87
0.13
1.2
1.6
—
—
—
0
0
121
1254
0.96
0.13
2.0
1.9
1.55
2.00
ug/l
0.24
102
1120
45
422
1.07
0.13
1.9
2.2
0.79
0.89
%
0.58
29
270
209
2145
0.97
0.13
9.0
9.8
0.63
0.65
%
0.33
209
2134
28
257
1.09
0.13
1.2
1.1
—
—
—
0
0
15
132
1.14
0.13
3.5
2.6
0.61
0.62
mmol/l
0.21
15
132
14
159
0.88
0.13
1.0
1.0
—
—
—
0
0
19
211
0.90
0.13
4.5
2.7
13.10
148.49
ug/l
0.78
19
197
132
1277
1.03
0.13
2.8
2.5
3.52
3.60
g/l
0.25
126
1218
1050
10403
1.01
0.12
1.9
2.0
—
—
—
0
0
44
414
1.06
0.12
1.3
1.1
40.33
36.03
mg/l
0.24
36
358
25
272
0.92
0.12
1.4
1.4
—
—
—
0
0
11
95
1.16
0.11
1.3
1.2
47.82
38.57
g/l
—
5
50
31
333
0.93
0.11
1.0
1.0
0.11
0.23
u/ml
—
5
73
44
415
1.06
0.11
1.1
1.2
—
—
—
0
0
28
302
0.93
0.11
1.0
1.5
15.54
7.81
ug/l
0.35
21
268
89
857
1.04
0.11
1.2
1.2
—
—
—
0
0
183
1875
0.98
0.11
1.2
1.2
—
—
—
0
0
26
281
0.92
0.11
1.3
1.2
—
—
—
0
0
106
1025
1.03
0.11
1.0
1.1
1.74
1.43
u/ml
0.17
56
499
304
2986
1.02
0.11
6.5
7.5
8.58
8.58
mmol/l
0.00
293
2878
97
938
1.03
0.10
1.2
1.2
261.40
263.03
u/ml
0.02
68
582
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
12
135
0.89
0.09
1.3
1.5
9.31
8.25
mmol/l
0.24
12
135
38
359
1.06
0.09
1.1
1.0
0.53
1.38
u/ml
—
6
81
38
359
1.06
0.09
3.2
3.0
54.90
56.49
%
0.17
31
322
144
1405
1.03
0.09
1.3
1.3
—
—
—
0
0
42
399
1.05
0.09
1.2
1.1
238.92
224.32
mg/l
0.20
36
357
219
2230
0.98
0.09
8.7
9.6
94.66
94.16
%
1.00
219
2221
30
282
1.06
0.08
1.3
1.4
20436.95
71569.94
e6/l
0.97
21
146
5
62
0.81
0.08
2.0
3.4
—
26.64
—
0
14
405
4002
1.01
0.08
2.0
2.1
0.00
0.02
estimate
1.95
69
869
7
64
1.09
0.08
1.4
2.0
—
—
—
0
0
7
65
1.08
0.08
1.1
1.8
—
—
—
0
0
7
67
1.04
0.08
3.0
2.6
—
—
—
0
0
6
71
0.84
0.07
1.3
2.5
12.67
5.32
ug/l
—
6
71
73
708
1.03
0.07
3.0
3.6
45.78
751.18
u/ml
1.21
68
648
30
284
1.06
0.07
1.6
1.6
—
—
—
0
0
12
108
1.11
0.07
1.0
1.2
44.33
67.39
ug/l
2.01
12
108
36
343
1.05
0.07
2.9
3.5
30.26
27.68
mu/l
0.17
36
330
115
1176
0.98
0.07
2.7
3.4
1.45
1.42
mg/l
0.16
109
1099
13
118
1.10
0.07
2.7
1.5
—
—
—
0
0
3552
35461
1.01
0.07
22.5
17.7
331.98
331.83
g/l
0.49
3539
35274
18
167
1.08
0.06
1.1
1.1
—
—
—
0
0
106
1084
0.98
0.06
1.0
1.1
3.44
5.05
u/ml
0.77
59
576
53
512
1.04
0.06
1.7
1.5
—
—
—
0
0
53
512
1.04
0.06
1.7
1.5
—
—
—
0
0
53
512
1.04
0.06
1.7
1.5
—
—
—
0
0
53
512
1.04
0.06
1.7
1.5
—
—
—
0
0
9
100
0.90
0.06
1.1
1.1
—
222.86
—
0
7
30
315
0.95
0.06
1.3
1.7
1.05
1.19
promille
0.23
24
250
16
148
1.08
0.06
1.2
1.2
27.94
28.28
s
0.10
16
148
22
207
1.06
0.06
1.5
3.2
—
—
—
0
0
63
648
0.97
0.05
2.2
1.6
—
—
—
0
0
198
2007
0.99
0.05
2.1
2.1
0.04
0.37
estimate
0.45
54
700
32
306
1.05
0.05
1.4
1.6
—
—
—
0
0
27
257
1.05
0.05
1.1
1.5
68.70
72.67
umol/l
0.68
27
257
14
151
0.93
0.05
1.1
1.4
—
—
—
0
0
16
149
1.07
0.05
1.8
1.4
16.65
17.16
umol/l
0.23
16
124
24
228
1.05
0.05
1.0
1.4
135.58
131.30
nmol/l
0.25
24
228
39
404
0.97
0.05
1.2
1.1
—
—
—
0
0
166
1638
1.01
0.05
1.5
1.6
—
—
—
0
0
219
2214
0.99
0.04
1.5
2.1
—
—
—
0
0
123
1249
0.98
0.04
1.1
1.1
2.22
1.88
u/ml
0.12
59
647
99
973
1.02
0.04
2.9
2.3
—
—
—
0
0
14
150
0.93
0.04
1.3
1.7
0.00
0.02
estimate
0.50
14
150
10
91
1.10
0.04
1.0
1.0
—
—
—
0
0
10
91
1.10
0.04
1.0
1.0
—
—
—
0
0
10
91
1.10
0.04
1.0
1.0
—
—
—
0
0
33
318
1.04
0.04
1.4
1.4
26928.74
114965.70
e6/l
1.33
19
214
36
372
0.97
0.04
1.1
1.1
—
—
—
0
0
52
533
0.98
0.04
1.1
1.1
—
—
—
0
0
15
141
1.06
0.03
1.3
1.4
197.28
146.12
pmol/l
0.67
15
141
161
1593
1.01
0.03
1.4
1.5
—
—
—
0
0
135
1334
1.01
0.03
4.5
5.8
0.81
0.90
%
1.61
127
1255
203
2012
1.01
0.03
4.3
7.1
24.62
24.45
mmol/l
0.32
192
1922
18
189
0.95
0.03
1.1
1.5
6.60
4.63
%
—
5
30
66
672
0.98
0.03
5.8
8.4
105.38
105.23
mmol/l
0.10
58
603
217
2187
0.99
0.03
1.5
2.1
—
—
—
0
0
66
671
0.98
0.02
5.8
8.4
11.22
11.12
mmol/l
0.10
58
602
70
689
1.02
0.02
1.5
1.4
6.45
7.06
mmol/l
1.80
63
626
219
2204
0.99
0.02
1.5
2.0
—
—
—
0
0
198
1968
1.01
0.02
1.9
1.9
—
—
—
0
0
32
312
1.03
0.02
1.6
1.2
—
—
—
0
0
158
1569
1.01
0.02
1.4
1.5
1.21
1.26
mm
0.77
106
1130
76
769
0.99
0.01
1.3
1.2
—
—
—
0
0
582
5807
1.00
0.01
1.8
1.9
3.48
3.39
ratio
0.61
440
4338
202
2029
1.00
0.01
1.5
2.1
—
—
—
0
0
42
413
1.02
0.01
1.0
1.1
7.38
9.23
iu/ml
0.41
11
120
219
2196
1.00
0.00
1.5
2.1
—
—
—
0
0
28
275
1.02
0.00
1.2
1.1
—
—
—
0
0
15
154
0.97
0.00
1.7
2.1
0.21
0.17
e9/l
—
8
77
43
426
1.01
0.00
1.7
2.3
1248.45
1312.59
e6/l
0.23
38
371
25
247
1.01
0.00
1.1
1.2
—
—
—
0
0
104
1044
1.00
0.00
1.0
1.1
0.40
1.00
u/ml
2.20
42
441
19
191
0.99
0.00
2.4
2.5
8.47
8.61
mmol/l
0.09
19
191
24
241
1.00
0.00
1.2
1.2
1483.33
1042.55
titre
—
6
47
30
299
1.00
0.00
1.7
2.2
534.40
538.80
e6/l
0.02
25
237
5
49
1.02
0.00
2.0
2.6
15.60
15.15
ml/dl
—
5
44
6
64
0.94
0.00
1.7
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
-0.00
1.0
1.1
0.02
0.03
u/ml
—
5
59
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.27
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.7
—
—
—
0
0
9
99
0.91
-0.00
1.2
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
37.17
—
0
6
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
6
69
0.87
-0.00
2.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.3
1.3
5.30
5.66
mmol/l
—
6
62
0
8
0.00
-0.00
0.0
1.3
—
34.57
—
0
8
28
280
1.00
-0.00
1.2
1.4
—
—
—
0
0
8
87
0.92
-0.00
1.1
1.2
0.01
5.67
u/ml
—
8
87
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
11
110
1.00
-0.00
1.4
1.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_GRAVES_STRICT and mortality.

Females

Parameter HR [95% CI] p-value
E4_GRAVES_STRICT 1.07 [0.94, 1.22] 0.294
Birth year 0.992 [0.98, 1.0] 0.082

During the follow-up period (1.1.1998 — 31.12.2019), 1142 out of 16342 females with E4_GRAVES_STRICT died.

Males

Parameter HR [95% CI] p-value
E4_GRAVES_STRICT 1.036 [0.89, 1.21] 0.654
Birth year 0.991 [0.98, 1.0] 0.053

During the follow-up period (1.1.1998 — 31.12.2019), 345 out of 3489 males with E4_GRAVES_STRICT died.

Mortality risk

Mortality risk for people of age

years, who have E4_GRAVES_STRICT.

N-year risk Females Males
1 0.062% 0.176%
5 0.599% 1.156%
10 1.414% 3.262%
15 2.705% 6.508%
20 4.747% 11.059%

Relationships between endpoints

↥

Index endpoint: E4_GRAVES_STRICT – Graves disease, strict definition

GWS hits: 24

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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