Benign neoplasm: Choroid

CD2_BENIGN_CHOROID

choroid cancer: Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D31.3&
  • Hospital discharge: ICD-9 2246
  • Cause of death: ICD-10 D31.3&
  • Cause of death: ICD-9 2246

2 out of 7 registries used, show all original rules.

2879

4. Check minimum number of events

None

2879

5. Include endpoints

None

2879

6. Filter based on genotype QC (FinnGen only)

2594

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D31
Name in latin
Neoplasma benignum chorioideae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11875 7347 4502
Only index persons 11506 7160 4346
Unadjusted period prevalence (%)
Whole population 0.18 0.21 0.13
Only index persons 0.23 0.26 0.17
Median age at first event (years)
Whole population 65.87 65.27 66.87
Only index persons 65.71 65.12 66.70

-FinnGen-

Key figures

All Female Male
Number of individuals 2594 1589 1005
Unadjusted period prevalence (%) 0.52 0.56 0.46
Median age at first event (years) 66.13 64.19 69.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2673
Matched controls
26730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.6
312.0
731
1680
XCK10
NOMESCO Finland
Photography of fundus of eye
6.1
307.7
715
1518
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
14.9
307.7
960
971
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
4503599627370496.0
307.7
2664
30
XCD10
NOMESCO Finland
Electrophysiological examination of eye
16.5
307.7
372
260
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
55.6
307.7
266
53
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.6
195.3
903
3336
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
59.2
173.2
97
17
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.4
127.9
541
1837
CKE60
NOMESCO Finland
Brachytherapy of choroid and retina
44.4
109.3
65
15
CKE65
NOMESCO Finland
Removal of brachytherapeutic plate from eye
43.7
107.2
64
15
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
26.0
102.2
71
28
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
18.7
97.8
78
43
XCD20
NOMESCO Finland
Photoangiography of eye
6.3
62.5
107
176
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
49.0
1356
9662
D31.2
ICD-10 Finland
Benign neoplasm: Retina
70.0
48.2
55
8
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
45.8
305
1287
C69.32
ICD-10 Finland
Malignant tumor of the chorioidea melanoma
78.1
41.0
46
6
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.9
32.0
475
2731
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
7.1
31.8
48
69
WX140
NOMESCO Finland
Parabulbar anesthesy
2.6
30.2
184
740
D31.4
ICD-10 Finland
Benign neoplasm: Ciliary body
83.6
29.8
33
*
XCH00
NOMESCO Finland
Eye pressure measurement
2.6
29.5
180
725
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.0
28.4
335
1777
CD2S4
NOMESCO Finland
Photography of eye
7.2
27.1
40
56
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
2.6
25.9
159
642
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
5.0
23.2
50
102
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
2.6
23.2
138
549
ZXA10
NOMESCO Finland
Bilateral
1.7
22.8
524
3392
H26.4
ICD-10 Finland
After-cataract
1.8
20.4
328
1916
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
20.4
811
5953
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
19.4
351
2122
XCW10
NOMESCO Finland
Assessment of vision
3.6
19.3
63
177
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
19.2
927
7061
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
2.1
18.3
191
965
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.8
18.0
266
1512
D31.0
ICD-10 Finland
Benign neoplasm: Conjunctiva
4.9
17.1
37
76
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
50.3
17.0
20
*
H31.9
ICD-10 Finland
Disorder of choroid, unspecified
63.7
16.7
19
*
A98
ICPC
Health maint/preventive medicine
2.4
16.6
2577
24531
H53.1
ICD-10 Finland
Subjective visual disturbances
1.9
15.2
200
1094
OAB50, ,
SPAT
1.8
15.1
232
1333
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.1
15.1
150
745
CK2J4
NOMESCO Finland
Infrared imaging of ocular fundus
+∞
14.6
14
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.7
14.4
257
1542
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
2.1
13.5
133
659
CH2S4
NOMESCO Finland
Photography of iris
40.3
13.1
16
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.6
12.9
372
2520
H40.0
ICD-10 Finland
Glaucoma suspect
1.7
12.3
230
1397
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.1
12.2
109
520
C69.3
ICD-10 Finland
Malignant neoplasm: Choroid
21.4
12.0
17
8
ZXA00
NOMESCO Finland
Right side
1.4
12.0
677
5217
CA1ME
NOMESCO Finland
Ultrasound oculometry
4.7
11.9
27
58
CKC12
NOMESCO Finland
Photocoagulation of retina
2.1
11.7
113
556
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.4
11.5
567
4265
H35.7
ICD-10 Finland
Separation of retinal layers
3.5
11.4
38
109
SPAT1153
SPAT
Removal of sutures
1.4
11.3
815
6525
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
4.6
11.2
26
57
ZXA05
NOMESCO Finland
Left side
1.4
11.1
623
4788
L17
ICPC
Foot/toe symptom/complaint
1.4
10.9
798
6394
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.3
10.9
867
7037
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
2.2
10.8
89
411
H25.0
ICD-10 Finland
Senile incipient cataract
1.7
10.8
191
1143
R01AD09
ATC
mometasone; nasal
1.3
10.7
1073
8998
J01DB01
ATC
cefalexin; oral
1.4
10.7
2097
19350
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
10.7
1267
10876
R44
ICPC
Respiratory, Preventive immunization/medic
2.8
10.7
52
188
H35.4
ICD-10 Finland
Peripheral retinal degeneration
4.3
10.6
27
64
SPAT1262
SPAT
Handing over of treatment supplies
1.4
10.5
434
3157
A02BC05
ATC
esomeprazole; systemic
1.3
10.5
1018
8494
E0000UV, ,
ATC
1.3
10.0
1016
8516
8720/3-C69.9
ICD-O-3
Malignant melanoma, NOS, of eye, NOS
40.2
10.0
12
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.4
9.9
627
4904
H3600, E113,
ICD-10 Finland
3.2
9.9
38
120
Z2221
NOMESCO Finland
Medical doctor
1.4
9.8
637
5002
C10AA05
ATC
atorvastatin; oral
1.3
9.7
1135
9680
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
2.2
9.4
73
330
F29
ICPC
Eye symptom/complaint other
1.5
9.4
267
1798
8720/3-C69.3
ICD-O-3
Malignant melanoma, NOS, of choroid
17.6
9.4
14
8
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
1.6
9.3
229
1492
C69.39
ICD-10 Finland
Malignant tumor in chorioidea other or unspecified histology
36.8
9.0
11
*
XCK00
NOMESCO Finland
Perimetry
1.7
9.0
153
908
SDA03
NOMESCO Finland
Periodontal treatment
1.3
8.9
946
7938
H31.8
ICD-10 Finland
Other specified disorders of choroid
24.1
8.9
12
5
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
8.8
679
5456
G04CB01
ATC
finasteride; oral
1.5
8.7
240
1606
A11
ICPC
Chest pain NOS
1.6
8.6
228
1511
F43
ICPC
Eye, Other diagnostic procedure
2.3
8.6
63
278
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
3.2
8.5
33
105
N02BE01
ATC
paracetamol; systemic, rectal
1.4
8.5
2344
22247
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
2.5
8.5
52
212
WX110
NOMESCO Finland
Infiltration anesthesia
1.3
8.3
1763
16074
WX720
NOMESCO Finland
Own respiration
1.8
8.3
128
738
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
8.2
604
4817
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.1
8.1
79
391
M01AH05
ATC
etoricoxib; oral
1.3
8.1
1533
13761
CF2S4
NOMESCO Finland
Photography of conjunctiva
10.0
8.0
15
15
SPAT1325
SPAT
Vaccination
1.3
7.9
812
6764
S82
ICPC
Naevus/mole
1.4
7.9
342
2503
D31.9
ICD-10 Finland
Benign neoplasm: Eye, unspecified
13.1
7.9
13
10
D31.1
ICD-10 Finland
Benign neoplasm: Cornea
45.1
7.7
9
*
R42
ICD-10 Finland
Dizziness and giddiness
1.3
7.7
576
4598
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
7.6
551
4375
S18
ICPC
Laceration/cut
1.3
7.5
1207
10590
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
7.5
840
7061
WX002
NOMESCO Finland
Sedation and analgesia
1.3
7.5
477
3717
F38
ICPC
Eye, Other laboratory test NEC
2.3
7.5
54
238
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.4
7.4
307
2226
Z010, D313,
ICD-10 Finland
+∞
7.3
7
*
1906B
ICD-9 Finland
Malignant neoplasm of eye, Choroid[MELANOMA CHORIOIDEAE]
+∞
7.3
7
*
SFA20
NOMESCO Finland
Two-surface restoration
1.2
7.3
1368
12202
M79.6
ICD-10 Finland
Pain in limb
1.3
7.3
1095
9527
J01FA10
ATC
azithromycin; systemic
1.2
7.3
1320
11730
L15
ICPC
Knee symptom/complaint
1.3
7.2
638
5204
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.4
7.1
318
2339
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
3.2
7.1
27
85
WX704
NOMESCO Finland
Intubation
1.5
7.0
195
1307
R01AD58
ATC
fluticasone, combinations; nasal
1.3
7.0
525
4183
SPAT1263
SPAT
Sampling
1.3
7.0
976
8410
WX142
NOMESCO Finland
Sub-tenon anesthesy
3.2
7.0
26
81
R01AD12
ATC
fluticasone furoate; nasal
1.3
7.0
681
5623
T90
ICPC
Diabetes non-insulin dependent
1.3
6.9
617
5032
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
4.1
6.8
18
44
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
1.5
6.8
178
1178
JAETT, ,
NOMESCO Finland
3.8
6.8
20
53
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
1.8
6.8
95
534
H25.8
ICD-10 Finland
Other senile cataract
1.4
6.8
283
2057
R4110, ,
SPAT
1.4
6.8
349
2629
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
1.8
6.8
96
542
SPAT1141
SPAT
Excision of skin or mucous membrane lesion
1.8
6.7
103
594
H3601, E103,
ICD-10 Finland
3.9
6.7
19
49
H35.9
ICD-10 Finland
Retinal disorder, unspecified
3.9
6.7
19
49
N17
ICPC
Vertigo/dizziness
1.4
6.7
326
2433
Z01.2
ICD-10 Finland
Dental examination
1.2
6.7
1072
9368
SPAT1310
SPAT
Counselling related to known health issue
1.3
6.7
738
6182
J01CA04
ATC
amoxicillin; systemic
1.3
6.6
2002
18742
H34.8
ICD-10 Finland
Other retinal vascular occlusions
2.1
6.6
58
278
C10AA01
ATC
simvastatin; oral
1.2
6.6
1055
9215
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
6.5
1005
8738
XKD00
NOMESCO Finland
Uroflowmetry
1.4
6.5
341
2578
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
6.4
424
3316
SDA04
NOMESCO Finland
Demanding periodontal treatment
1.3
6.4
645
5336
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.4
6.4
280
2051
K07.60
ICD-10 Finland
Snapping jaw
1.7
6.4
108
641
UDC00
NOMESCO Finland
Ear microscopy
1.5
6.4
167
1105
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.6
6.4
144
922
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
4.1
6.4
17
42
J01MA02
ATC
ciprofloxacin; systemic
1.2
6.3
923
7970
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
3.3
6.3
23
71
2246A
ICD-9 Finland
Benign neoplasm of eye, Choroid
+∞
6.3
6
*
G04BD12
ATC
mirabegron; oral
1.4
6.2
316
2375
103
Kela drug reimbursment
Diabetes, insulin-treated
1.3
6.2
641
5318
L01
ICPC
Neck symptom/complaint
1.3
6.2
382
2957
SFA10
NOMESCO Finland
One-surface restoration
1.2
6.2
1276
11416
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.4
6.1
226
1605
T89
ICPC
Diabetes insulin dependent
1.8
6.1
82
457
UKC02
NOMESCO Finland
Cystoscopy
1.3
6.0
368
2844
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
6.0
625
5188

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
2426
22335
1.93
21.56
7.7
6.8
40.06
39.67
mmol/mol
1.43
2250
20822
2619
24966
3.43
19.98
29.1
26.8
249.16
250.17
e9/l
0.34
2574
24461
2619
24971
3.42
19.87
28.9
26.7
91.27
91.46
fl
1.40
2591
24695
2619
24972
3.41
19.85
29.5
27.3
41.65
40.00
%
0.64
2591
24686
2619
24972
3.41
19.85
28.9
26.7
30.35
30.37
pg
0.25
2591
24694
2619
24973
3.41
19.83
29.0
26.8
4.46
4.44
e12/l
1.76
2559
24380
2619
24974
3.41
19.80
29.1
26.8
6.68
6.75
e9/l
0.70
2562
24380
2619
24978
3.40
19.72
29.2
27.0
134.68
133.78
g/l
2.75
2591
24711
2501
23430
2.05
18.64
6.9
6.2
2.59
2.67
mmol/l
4.15
2303
21681
2574
24399
2.48
18.43
14.9
13.1
25.24
25.27
u/l
0.04
2493
23702
2590
24624
2.67
18.35
25.5
23.2
78.88
78.08
umol/l
0.51
2564
24340
2464
23065
1.87
16.94
5.9
5.4
4.56
4.61
mmol/l
1.82
2277
21454
2450
22919
1.83
16.52
5.8
5.3
1.48
1.48
mmol/l
0.05
2253
21170
2469
23168
1.86
16.24
18.6
17.6
23.10
24.73
mg/l
1.69
2041
19302
2360
21902
1.66
15.68
6.2
5.7
1.89
1.95
mu/l
1.49
2179
20203
2529
23966
2.03
15.42
22.7
21.0
139.81
139.69
mmol/l
1.73
2490
23529
2531
24008
2.02
15.13
22.8
21.2
3.98
3.98
mmol/l
0.06
2486
23537
2426
22771
1.71
14.26
6.1
5.5
5.98
5.98
mmol/l
0.00
2221
20821
1246
10440
1.36
13.50
2.1
2.0
1.31
1.35
mmol/l
1.05
1038
8723
2103
19207
1.45
13.21
9.7
8.6
77.93
80.01
u/l
1.39
1995
18257
1410
12073
1.36
13.13
7.2
6.7
1.22
1.21
mmol/l
1.67
1292
11168
1635
14356
1.36
12.74
9.9
9.9
4.06
4.13
e9/l
0.59
1433
12439
1087
8975
1.36
12.68
4.7
4.2
9.42
8.69
mg/mmol
0.17
669
5527
2017
18332
1.41
12.61
5.0
4.6
12.05
12.96
mm/h
2.09
1878
17144
1205
10122
1.35
12.49
2.5
2.2
—
—
—
0
0
2048
18680
1.41
12.40
4.9
4.6
14.93
14.90
pmol/l
0.16
1865
17102
1099
9125
1.35
12.22
3.9
3.4
7.17
7.21
mmol/l
0.10
902
7693
1065
8814
1.35
12.05
4.0
3.5
48.03
46.07
mg/l
0.09
671
5576
1530
13398
1.33
11.58
8.0
7.5
1.22
1.21
mmol/l
1.25
1288
11598
1364
11793
1.32
11.07
2.3
2.2
98.04
95.98
pmol/l
0.74
667
6128
1395
12122
1.32
10.81
16.2
16.3
1.24
1.27
inr
1.33
1188
10125
1040
8702
1.32
10.48
6.5
6.3
—
—
—
0
0
2330
21946
1.48
10.25
4.8
4.5
1.27
1.29
mmol/l
0.61
2127
20047
1492
13187
1.30
9.73
6.7
6.6
0.19
0.19
e9/l
0.31
1322
11428
1794
16337
1.30
8.86
5.4
5.0
2698.37
1800.36
e6/l
0.13
16
239
105
558
1.92
8.82
5.3
7.5
11.27
11.28
mmol/l
0.01
93
503
105
558
1.92
8.82
5.3
7.5
105.05
105.05
mmol/l
0.00
93
503
1335
11743
1.27
8.55
2.7
2.5
80.92
79.03
nmol/l
1.50
1191
10570
1440
12801
1.27
8.39
6.6
6.4
0.04
0.04
e9/l
0.61
1256
10911
1337
11780
1.27
8.38
6.9
6.7
8.81
8.93
%
0.97
1263
11041
1436
12766
1.27
8.34
6.6
6.3
0.58
0.59
e9/l
0.90
1254
10880
1333
11766
1.27
8.13
6.8
6.6
2.78
2.83
%
0.35
1258
11027
135
797
1.73
8.08
5.2
6.4
1.30
1.32
mmol/l
0.05
117
703
1332
11762
1.26
8.08
6.9
6.7
0.68
0.68
%
0.03
1257
11016
2049
19082
1.32
8.06
22.8
21.8
13.67
13.73
%
1.30
2021
18831
1331
11777
1.26
7.84
6.7
6.5
57.27
57.60
%
0.48
1275
11249
1456
13022
1.26
7.80
6.7
6.4
1.92
1.91
e9/l
0.06
1294
11384
677
5518
1.30
7.76
1.4
1.3
1.39
1.30
u/ml
0.09
168
1444
1513
13611
1.26
7.63
7.4
6.8
11.10
11.50
umol/l
1.05
1445
13012
1351
12007
1.25
7.54
6.8
6.6
27.92
27.26
%
1.36
1288
11378
400
3039
1.37
7.38
1.9
2.3
118.01
134.83
ug/g
0.38
320
2429
1278
11340
1.24
7.04
3.2
3.1
120.96
130.85
ug/l
1.07
1180
10537
273
1960
1.44
6.99
1.2
1.2
—
—
—
0
0
90
495
1.85
6.88
2.0
1.9
5.47
4.89
mmol/24h
0.76
75
428
901
7764
1.24
6.28
5.9
6.4
—
—
—
0
0
1629
14949
1.23
6.17
5.8
5.2
6.76
6.74
mmol/l
0.11
1565
14267
293
2187
1.38
6.01
3.6
3.8
87.97
90.81
ng/l
0.20
247
1881
296
2215
1.38
5.97
4.2
3.0
173.20
197.57
ng/l
0.46
269
2029
439
3485
1.31
5.97
1.3
1.3
615.06
534.49
titre
0.27
85
795
1453
13221
1.22
5.82
4.5
4.2
0.01
2.83
estimate
1.58
302
2875
1463
13326
1.22
5.78
4.5
4.2
0.00
0.12
estimate
0.56
296
2686
938
8176
1.23
5.75
3.0
2.7
57.93
70.73
u/l
0.70
866
7588
836
7208
1.23
5.68
6.6
5.8
2.55
2.80
ug/l
0.39
751
6499
1435
13060
1.21
5.67
4.4
4.1
0.00
0.00
estimate
0.42
303
2785
800
6877
1.23
5.57
3.5
3.6
1.06
0.14
estimate
0.43
246
2179
937
8199
1.22
5.47
5.0
4.3
7.40
7.40
ph
0.24
683
5942
1683
15595
1.21
5.39
3.7
3.4
47.31
50.79
u/l
0.67
1571
14553
229
1676
1.40
5.29
8.0
7.0
24.68
24.46
mmol/l
0.38
218
1609
943
8283
1.21
5.24
2.2
2.2
168.36
215.20
u/l
1.50
895
7830
378
2998
1.30
5.15
1.3
1.3
—
—
—
0
0
579
4860
1.24
4.95
1.6
1.5
2.30
2.50
g/l
1.91
335
2925
1166
10495
1.20
4.91
3.8
3.6
6.21
6.25
ph
0.63
660
5836
1298
11801
1.19
4.87
5.7
5.2
35.70
35.35
g/l
1.44
1211
11100
894
7867
1.20
4.78
1.7
1.7
21.31
20.54
nmol/l
0.64
747
6611
1094
9820
1.19
4.68
4.4
4.0
28.22
109.13
ng/l
1.14
755
7229
57
310
1.86
4.63
1.1
1.1
5.69
3.60
u/ml
0.43
33
151
322
2537
1.31
4.61
2.2
2.2
0.00
0.01
estimate
0.78
63
521
1090
9795
1.19
4.57
4.3
4.1
2.10
0.10
estimate
0.47
240
2278
178
1281
1.42
4.56
2.3
2.2
0.00
0.63
estimate
0.50
48
396
938
8326
1.20
4.50
3.9
3.2
30.07
33.46
u/l
2.38
891
7852
187
1362
1.40
4.47
2.4
2.4
—
—
—
0
0
205
1534
1.36
4.18
4.0
3.5
4.40
4.45
pmol/l
0.36
183
1358
65
381
1.72
4.15
1.1
1.1
0.20
1.73
u/ml
3.12
34
209
54
304
1.79
3.97
1.1
1.1
0.67
1.30
u/ml
0.52
24
125
161
1178
1.39
3.79
1.3
1.2
—
—
—
0
0
663
5794
1.19
3.67
4.6
4.4
1.02
1.27
kg/l
0.50
478
3913
100
674
1.50
3.65
2.4
2.1
12.44
12.25
mg/l
0.09
90
625
251
1985
1.29
3.52
3.0
3.0
10.17
10.58
g/l
0.83
228
1823
826
7381
1.17
3.48
4.8
4.3
0.00
0.00
estimate
1.54
275
2595
121
856
1.43
3.47
1.4
1.4
29.31
31.85
iu/l
0.38
107
739
436
3681
1.22
3.46
1.3
1.3
—
—
—
0
0
205
1581
1.32
3.46
1.3
1.3
129.54
198.70
u/ml
1.14
189
1468
49
281
1.76
3.43
1.0
1.1
1.44
1.10
u/ml
0.14
25
141
594
5168
1.19
3.43
4.6
4.1
393.58
382.30
ng/l
0.02
478
4181
413
3489
1.22
3.26
1.4
1.3
—
—
—
0
0
920
8325
1.16
3.26
3.4
3.2
1545.22
1334.29
ng/l
0.41
785
7237
10
24
4.18
3.19
3.9
2.7
—
—
—
0
0
629
5535
1.18
3.16
2.0
1.8
1.01
1.32
mg/l
2.93
487
4340
386
3249
1.22
3.16
2.6
3.4
4.21
4.61
e9/l
0.97
326
2794
296
2426
1.25
3.11
3.1
2.9
66.04
66.32
g/l
0.29
264
2229
33
173
1.92
3.09
1.1
1.1
42.32
41.13
mg/l
0.04
28
144
745
6659
1.16
3.07
3.0
2.9
342.94
343.53
umol/l
0.05
637
5854
374
3149
1.22
3.05
5.8
5.2
33.46
32.92
%
0.42
246
2053
203
1603
1.29
2.92
9.5
10.0
16.10
15.89
%
0.49
194
1551
201
1586
1.29
2.91
2.3
1.9
1.33
1.41
g/l
0.15
181
1449
493
4287
1.18
2.84
3.8
3.4
0.74
0.76
ug/l
0.30
335
2924
41
238
1.73
2.81
1.0
1.1
0.87
3.85
u/ml
1.78
18
101
31
165
1.89
2.80
1.0
1.1
264.12
292.03
mg/l
0.30
26
141
1263
11777
1.14
2.78
2.9
2.9
—
—
estimate
—
0
0
25
124
2.03
2.76
1.1
1.2
0.48
0.52
ratio
0.59
11
76
769
6941
1.15
2.74
3.0
3.2
0.18
0.03
0.38
17
181
150
1148
1.32
2.73
1.6
2.7
2.65
2.93
g/l
2.96
131
1046
24
118
2.04
2.71
2.6
2.6
1850.46
990.76
u/ml
0.41
24
118
71
481
1.49
2.62
1.5
1.4
11.38
11.27
u/l
0.02
56
390
350
2983
1.20
2.53
1.7
1.8
—
—
—
0
0
156
1216
1.30
2.51
1.7
2.6
3.42
3.73
g/l
2.22
137
1114
156
1217
1.30
2.50
1.7
2.6
4.14
4.22
g/l
0.68
137
1115
156
1217
1.30
2.50
1.7
2.6
7.11
7.41
g/l
1.52
137
1113
99
722
1.39
2.48
1.1
1.1
—
—
—
0
0
18
82
2.20
2.47
3.4
2.3
905.01
119.21
ug/l
0.41
18
70
599
5349
1.15
2.45
5.2
4.9
—
—
—
0
0
84
597
1.42
2.44
1.5
1.3
3.79
3.78
mmol/l
0.03
78
562
194
1561
1.26
2.44
1.3
1.3
90.85
57.44
au/ml
—
10
113
22
110
2.01
2.40
1.1
1.1
3936.11
410.51
ng/l
—
9
33
348
2982
1.19
2.38
3.4
2.7
8.04
7.98
umol/l
0.02
307
2648
515
4561
1.16
2.36
2.7
2.7
12.97
12.68
umol/l
0.42
470
4260
13
52
2.51
2.36
1.2
1.0
—
—
—
0
0
77
543
1.43
2.35
1.6
1.4
—
—
—
0
0
36
214
1.69
2.32
2.8
3.1
98.12
32.01
mg/l
0.41
27
160
56
372
1.52
2.31
1.6
1.4
23.22
64.51
mu/l
1.80
50
334
47
302
1.57
2.25
1.6
1.5
49.67
60.35
%
0.98
30
191
280
2369
1.20
2.21
1.5
1.4
—
—
—
0
0
17
80
2.13
2.18
1.5
1.5
7.47
7.32
mmol/l
0.04
17
80
82
594
1.39
2.18
1.1
1.1
3.68
5.35
eliau/ml
—
9
56
237
1977
1.22
2.17
4.9
4.3
—
—
—
0
0
204
1677
1.23
2.15
2.5
2.3
13.47
12.96
nmol/l
0.35
182
1497
100
1316
0.75
2.13
3.2
3.6
1.02
1.02
ratio
0.09
90
1197
496
4414
1.15
2.12
1.3
1.3
10.86
11.88
u/ml
0.12
184
1640
510
4553
1.15
2.09
1.8
1.8
1217.53
1170.88
nmol/l
0.54
379
3440
144
1142
1.28
2.08
4.7
5.6
0.91
0.87
%
0.73
133
1082
999
9318
1.12
2.00
4.0
3.6
2.36
2.36
mmol/l
0.29
887
8457
35
217
1.62
1.97
1.3
1.2
107.34
105.39
pmol/l
0.13
35
217
300
2584
1.18
1.96
4.6
4.5
7.36
7.36
ph
0.26
211
1844
132
1045
1.28
1.95
1.7
2.7
9.22
10.30
g/l
2.42
112
935
40
607
0.65
1.95
3.7
4.5
—
—
—
0
0
51
347
1.48
1.92
1.5
1.3
289.81
315.21
pmol/l
0.31
43
297
12
52
2.31
1.87
1.8
1.8
0.20
0.14
e9/l
—
7
18
11
46
2.40
1.85
1.2
1.5
—
—
—
0
0
192
2294
0.82
1.84
3.2
3.0
4.52
4.52
kpa
0.01
186
2228
55
385
1.44
1.81
1.7
2.5
—
—
—
0
0
22
123
1.80
1.80
1.6
1.7
39.05
39.75
g/l
0.24
22
123
35
223
1.58
1.79
4.9
5.3
43.27
44.40
u/ml
0.02
14
67
39
255
1.54
1.79
3.1
4.3
—
—
—
0
0
27
161
1.68
1.78
2.3
2.2
1.42
2.06
ug/l
1.42
19
140
34
216
1.58
1.76
1.0
1.1
0.03
0.24
u/ml
—
7
77
1946
18871
1.11
1.75
24.2
22.9
332.38
331.58
g/l
3.92
1939
18767
12
54
2.23
1.74
9.3
7.6
6.42
5.48
kpa
0.54
12
54
39
257
1.53
1.73
1.3
1.4
37.20
31.09
u/l
0.46
34
210
795
7373
1.11
1.73
4.5
4.5
—
—
—
0
0
40
266
1.51
1.71
1.2
1.2
—
—
—
0
0
54
383
1.42
1.68
1.3
1.3
0.61
5.28
nmol/l
0.50
54
367
364
3225
1.15
1.68
7.9
7.7
7.41
7.42
ph
0.15
222
1757
202
1707
1.20
1.67
2.6
2.5
24.00
23.43
au/ml
0.03
25
161
515
4674
1.13
1.64
1.3
1.3
46.62
35.68
iu/ml
0.27
158
1474
11
49
2.25
1.63
1.0
1.1
—
—
—
0
0
25
150
1.67
1.63
5.8
6.8
15.14
149.17
ug/l
0.56
14
88
89
688
1.30
1.62
2.0
2.0
3.74
12.55
iu/l
0.52
40
272
156
1290
1.22
1.62
2.0
2.0
—
—
—
0
0
352
3122
1.15
1.60
1.6
1.5
—
—
—
0
0
360
3198
1.15
1.60
7.9
7.6
0.91
1.01
mmol/l
0.21
290
2638
471
4258
1.13
1.60
2.7
2.7
2.31
2.30
g/l
0.16
424
3945
38
254
1.50
1.60
1.0
1.1
1.62
2.32
u/ml
0.29
15
121
36
238
1.52
1.60
2.5
2.5
—
—
—
0
0
280
2447
1.16
1.57
2.4
2.2
358.11
381.93
nmol/l
1.42
254
2266
331
2932
1.15
1.54
5.0
4.3
15.15
18.99
ug/l
0.22
276
2399
44
306
1.45
1.54
2.9
2.7
—
—
—
0
0
188
1593
1.19
1.53
1.2
1.2
82.47
141.43
u/ml
2.71
67
589
502
4569
1.12
1.53
4.1
3.3
0.83
0.82
mmol/l
1.01
461
4314
881
8262
1.10
1.51
3.4
3.4
—
—
—
0
0
77
590
1.31
1.51
4.2
4.0
—
—
—
0
0
6
21
2.86
1.50
1.8
1.7
—
—
—
0
0
598
5505
1.11
1.48
1.8
1.8
48967381.02
30261004.17
pmol/l
0.27
484
4567
406
3658
1.13
1.47
6.3
5.9
1.04
1.04
mmol/l
0.02
361
3393
436
3949
1.12
1.45
2.6
2.7
22.78
22.19
%
0.44
394
3684
75
577
1.31
1.44
1.5
1.4
13.93
39.22
e6/l
0.89
58
432
91
719
1.28
1.44
1.3
1.2
410.00
1230.00
titre
—
5
21
126
1034
1.23
1.44
1.6
1.9
8.73
7.72
iu/ml
0.11
27
248
149
1244
1.21
1.43
4.7
5.3
1.70
1.55
%
1.27
138
1180
21
125
1.69
1.43
1.1
1.1
1.07
1.06
ratio
0.19
15
104
104
836
1.25
1.43
1.4
1.4
282.90
276.70
ug/g
0.12
60
505
303
2690
1.14
1.38
8.7
8.3
119.39
120.47
g/l
0.42
294
2635
96
768
1.26
1.38
1.2
1.2
48.24
42.45
u/ml
—
7
43
114
932
1.23
1.36
3.8
3.9
24.73
24.93
mmol/l
0.33
96
865
123
1016
1.22
1.33
3.4
3.8
43.23
108.83
mg/l
0.67
103
877
123
1016
1.22
1.33
3.4
3.8
35.06
71.71
mg/l
1.50
104
878
359
3231
1.13
1.33
8.0
7.6
12.18
12.26
kpa
0.11
344
3118
359
3231
1.13
1.33
8.0
7.6
5.04
5.10
kpa
0.65
343
3118
118
971
1.23
1.33
1.2
1.3
2.23
1.17
u/ml
0.23
13
72
75
585
1.29
1.33
1.6
1.5
351.40
818.98
e6/l
0.82
58
465
200
1728
1.17
1.33
3.8
3.7
7.41
7.42
ph
0.37
159
1452
243
2761
0.87
1.32
3.5
3.6
5.87
5.81
kpa
0.50
236
2687
45
325
1.39
1.32
1.3
1.3
—
—
nmol/l
—
0
0
283
2516
1.14
1.28
2.3
2.7
70.77
70.04
e9/l
0.10
219
1850
745
6983
1.09
1.27
2.5
2.4
2.52
2.88
mg/l
5.37
639
6051
12
62
1.94
1.27
1.4
1.1
282.00
288.42
pmol/l
—
6
45
321
2881
1.13
1.26
8.3
7.9
95.63
95.59
%
0.03
307
2792
39
539
0.72
1.25
3.1
3.8
29.67
26.87
mg/l
0.13
27
376
179
1543
1.17
1.24
1.4
1.4
—
—
—
0
0
112
926
1.22
1.22
1.3
1.2
—
—
—
0
0
54
409
1.33
1.20
1.4
1.6
1.05
0.79
g/l
0.23
40
326
85
685
1.25
1.18
1.7
1.6
11818.49
12334.20
e6/l
0.04
55
480
238
2684
0.88
1.18
3.5
3.6
1.98
1.84
mmol/l
0.25
216
2335
95
776
1.23
1.18
3.1
3.1
1.67
1.60
mg/l
0.35
87
698
203
1779
1.15
1.15
3.8
3.7
5.12
5.15
kpa
0.20
188
1716
109
906
1.21
1.15
3.3
3.5
2.49
3.42
ratio
0.45
62
538
891
8457
1.08
1.12
3.3
3.3
—
—
—
0
0
18
111
1.63
1.12
1.1
1.3
149.00
168.57
mmol/24h
0.47
18
111
778
7349
1.08
1.10
3.7
3.4
0.36
0.45
e6/l
0.55
577
5438
122
1436
0.84
1.08
3.4
2.6
0.58
0.61
%
0.78
122
1427
26
177
1.47
1.07
2.4
1.6
360.33
319.84
mu/l
0.20
21
139
34
244
1.40
1.07
1.2
1.5
2.80
2.93
g/l
0.16
22
181
34
244
1.40
1.07
1.2
1.5
0.34
0.40
g/l
0.52
23
181
34
244
1.40
1.07
1.2
1.5
6.11
6.80
g/l
0.64
23
181
696
6554
1.08
1.06
4.0
4.2
89.03
89.02
%
0.01
673
6414
46
349
1.32
1.04
1.0
1.1
—
—
—
0
0
152
1315
1.17
1.04
1.6
1.7
—
—
—
0
0
88
725
1.22
1.03
1.2
1.3
7.43
7.07
u/ml
—
9
122
20
299
0.67
1.02
1.2
1.2
—
—
—
0
0
119
1012
1.18
1.01
3.3
2.5
—
—
—
0
0
46
351
1.32
1.01
1.0
1.1
—
—
—
0
0
47
361
1.31
0.99
1.4
1.4
—
—
—
0
0
47
361
1.31
0.99
1.4
1.4
—
—
—
0
0
47
361
1.31
0.99
1.4
1.4
—
—
—
0
0
47
361
1.31
0.99
1.4
1.4
—
—
—
0
0
34
249
1.37
0.97
1.4
1.3
154368.05
107476.98
e6/l
0.12
19
165
18
116
1.56
0.96
3.1
2.8
—
—
—
0
0
125
1450
0.86
0.95
3.3
2.7
1.23
1.17
%
0.31
125
1438
69
561
1.24
0.94
2.7
2.7
15.94
16.28
%
0.34
69
552
252
2784
0.90
0.93
3.6
3.7
7.38
7.38
ph
0.35
136
1580
199
2227
0.89
0.92
2.5
2.4
6.31
6.89
ug/l
0.23
164
1995
264
2396
1.11
0.90
4.7
4.5
1.07
0.91
%
0.36
83
742
27
193
1.40
0.90
1.2
1.2
0.62
1.13
u/ml
0.42
16
104
630
5951
1.08
0.89
3.1
2.8
5.74
5.70
e6/l
0.01
584
5426
44
341
1.30
0.89
1.3
1.3
0.18
0.24
nmol/l
0.66
37
273
33
245
1.35
0.89
1.2
1.5
—
—
—
0
0
139
1213
1.15
0.88
3.7
3.8
—
—
—
0
0
86
721
1.20
0.88
1.3
1.2
66.67
92.03
titre
—
9
59
241
2182
1.11
0.87
4.6
3.9
1.23
1.23
mmol/l
0.07
202
1893
290
2652
1.10
0.87
2.4
2.2
0.21
0.21
g/l
0.09
273
2480
41
316
1.30
0.87
1.8
1.5
22.74
28.84
ng/l
0.49
41
316
48
378
1.27
0.87
4.9
2.7
—
—
—
0
0
143
1253
1.15
0.86
1.4
1.2
—
—
—
0
0
71
586
1.22
0.86
2.7
2.4
213.02
108.68
ug/min
0.37
38
360
6
31
1.94
0.84
1.0
1.1
0.05
0.02
u/ml
—
6
31
24
332
0.72
0.84
1.3
1.7
—
—
—
0
0
32
239
1.34
0.84
1.2
1.1
—
—
—
0
0
40
309
1.30
0.84
1.5
1.9
—
—
—
0
0
252
2293
1.11
0.83
4.6
4.3
0.66
0.67
%
0.05
82
706
65
534
1.22
0.83
4.1
4.6
2.57
2.66
mmol/l
0.09
47
378
23
163
1.41
0.82
2.3
1.7
—
—
—
0
0
6
32
1.88
0.81
1.0
1.3
—
—
—
0
0
6
32
1.88
0.81
1.5
1.7
—
—
—
0
0
6
32
1.88
0.81
1.0
1.3
—
—
—
0
0
6
32
1.88
0.81
1.0
1.3
—
—
—
0
0
22
155
1.42
0.81
1.3
1.0
—
—
—
0
0
41
321
1.28
0.79
2.8
3.4
7.07
22.56
nmol/l
0.43
41
312
41
321
1.28
0.79
1.2
1.2
—
—
—
0
0
47
375
1.26
0.78
1.2
1.1
35.83
18.38
au/ml
—
7
78
251
2293
1.10
0.78
4.8
4.6
0.07
0.12
%
0.74
71
642
33
253
1.31
0.75
1.3
1.7
—
1744.00
—
0
5
9
54
1.67
0.74
1.4
2.2
—
—
—
0
0
17
116
1.47
0.74
1.2
1.1
—
—
—
0
0
252
2311
1.10
0.74
5.0
4.8
0.24
0.22
%
0.02
72
608
37
289
1.28
0.74
4.0
6.0
7.01
7.44
mmol/l
0.41
28
243
7
38
1.84
0.73
2.4
2.2
16.71
18.91
umol/l
—
7
38
40
316
1.27
0.73
1.4
1.2
—
—
—
0
0
105
914
1.15
0.73
1.5
1.6
9.93
16.24
u/ml
0.50
20
178
19
264
0.72
0.71
3.7
3.4
11.89
11.65
index
—
9
153
5
26
1.92
0.70
1.6
1.6
0.48
0.49
e9/l
—
5
26
399
3744
1.08
0.69
2.1
2.1
—
—
—
0
0
73
621
1.18
0.68
2.1
1.7
—
—
—
0
0
9
59
1.53
0.68
3.2
2.8
414.44
5.07
ug/l
—
9
59
882
8497
1.06
0.68
3.9
3.5
106.42
78.04
e6/l
0.25
683
6530
5
92
0.54
0.67
2.0
1.9
—
—
—
0
0
34
267
1.28
0.67
1.7
1.5
0.47
0.31
nmol/l
0.37
23
198
66
558
1.19
0.66
1.2
1.2
61.02
46.95
u/ml
0.25
13
62
54
448
1.21
0.66
2.1
1.8
201.39
203.54
pmol/l
0.05
54
423
41
332
1.24
0.63
1.3
1.2
—
—
—
0
0
69
590
1.17
0.62
3.5
3.5
0.87
0.81
nmol/l
0.40
54
483
5
30
1.67
0.61
1.0
1.2
1.51
1.81
umol/24h
—
5
30
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
986
9557
1.05
0.60
4.7
4.1
100.05
105.47
e6/l
0.08
723
6805
0
22
0.00
0.59
0.0
1.6
—
0.06
—
0
14
64
547
1.17
0.59
3.9
3.2
55.94
57.86
%
0.66
64
547
26
201
1.30
0.59
1.2
1.2
—
—
—
0
0
7
113
0.62
0.58
7.1
15.6
878.57
835.83
nmol/l
—
7
108
15
106
1.42
0.57
13.3
6.5
221.56
67.61
mg/l
—
9
79
48
571
0.84
0.57
1.3
1.3
146.86
216.44
miu/ml
0.65
15
255
6
36
1.67
0.56
1.2
1.6
—
—
—
0
0
217
2008
1.09
0.56
2.0
2.0
3.46
3.46
ratio
0.00
164
1587
20
150
1.34
0.55
2.1
2.2
515.80
496.15
min
—
10
111
6
37
1.62
0.55
2.5
4.5
50.00
42.30
umol/l
—
6
29
22
168
1.31
0.55
1.6
2.0
8.40
6.94
mmol/l
0.56
15
106
6
38
1.58
0.54
1.0
1.0
—
—
—
0
0
36
294
1.23
0.54
1.7
1.4
—
—
—
0
0
14
99
1.42
0.54
1.3
1.1
—
—
—
0
0
28
222
1.26
0.54
1.3
1.5
40.17
31.31
%
0.46
12
136
31
249
1.25
0.53
1.2
1.2
—
—
—
0
0
12
170
0.70
0.53
1.4
2.1
8.29
8.69
mmol/l
0.11
12
170
23
178
1.29
0.53
2.7
1.8
141.27
104.50
ng/l
0.53
23
178
43
360
1.20
0.51
1.1
1.1
1.46
1.52
g/l
0.40
36
328
41
342
1.20
0.51
1.5
2.4
—
—
—
0
0
32
391
0.82
0.51
1.7
1.6
828.87
973.39
mu/l
0.88
27
319
15
109
1.38
0.51
1.7
1.3
163.20
154.76
pmol/l
0.10
15
109
9
65
1.39
0.50
1.0
1.2
—
—
—
0
0
36
297
1.22
0.50
1.5
1.2
—
—
—
0
0
158
1718
0.91
0.50
3.4
3.0
128.89
128.15
g/l
0.17
151
1667
49
417
1.18
0.50
2.5
2.1
2884.23
3603.72
u/l
0.12
18
169
22
171
1.29
0.49
1.2
1.1
—
—
—
0
0
113
1022
1.11
0.49
1.1
1.1
—
—
—
0
0
158
1454
1.09
0.48
1.7
1.8
3.53
3.48
mmol/l
0.25
107
1030
427
4076
1.06
0.48
2.1
2.1
29.38
29.68
s
0.50
415
3962
14
102
1.37
0.47
1.1
1.3
—
0.25
—
0
10
190
1766
1.08
0.47
1.4
1.4
—
—
—
0
0
12
85
1.41
0.47
1.3
1.2
—
—
—
0
0
77
683
1.13
0.46
1.3
1.3
—
—
—
0
0
49
569
0.86
0.46
2.9
2.7
31.44
34.06
umol/l
0.35
43
511
48
411
1.17
0.46
1.9
2.2
1.06
0.90
%
0.45
36
288
16
120
1.34
0.46
1.1
1.0
—
—
—
0
0
80
716
1.12
0.43
1.1
1.1
—
—
—
0
0
124
1138
1.09
0.42
1.8
1.9
3.57
1.92
ug/l
0.58
103
1017
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
20
250
0.80
0.41
1.5
2.3
—
—
—
0
0
41
351
1.17
0.41
2.9
2.3
457.32
927.60
u/ml
0.23
41
343
0
16
0.00
0.41
0.0
1.3
—
17.43
—
0
11
8
59
1.36
0.41
1.1
1.1
—
—
—
0
0
48
417
1.15
0.40
2.0
1.9
1.97
1.70
mmol/l
0.82
48
407
14
183
0.76
0.40
1.5
1.6
—
—
—
0
0
5
35
1.43
0.39
9.0
15.4
4.52
5.08
mmol/l
—
5
35
225
2382
0.94
0.39
8.7
8.5
—
—
—
0
0
27
224
1.21
0.38
1.0
1.1
—
—
—
0
0
34
289
1.18
0.38
1.5
1.4
—
—
—
0
0
57
505
1.13
0.37
1.2
1.5
0.76
0.84
nmol/l
0.37
41
424
264
2509
1.06
0.37
2.7
2.4
34.71
58.33
u/l
0.65
232
2116
9
69
1.31
0.37
1.1
1.0
—
—
—
0
0
51
449
1.14
0.37
1.4
1.4
—
—
—
0
0
10
72
1.39
0.37
1.5
1.3
—
—
—
0
0
9
70
1.29
0.36
3.6
2.3
—
—
—
0
0
634
6157
1.04
0.36
4.5
4.0
0.50
0.13
—
6
70
9
71
1.27
0.36
1.1
2.0
1.99
1.17
ug/l
—
9
66
186
1751
1.07
0.35
1.3
1.3
—
—
—
0
0
23
190
1.21
0.34
1.4
1.3
—
—
—
0
0
22
181
1.22
0.34
1.2
1.2
390.91
385.43
nmol/l
0.06
22
156
14
178
0.79
0.34
1.4
1.5
—
—
—
0
0
6
45
1.33
0.33
1.0
1.2
65.50
69.24
ug/l
—
6
45
346
3324
1.05
0.33
1.8
1.7
—
—
—
0
0
336
3228
1.05
0.32
2.2
2.7
1.86
1.84
%
0.12
292
2892
66
728
0.90
0.32
2.9
3.5
1.26
2.02
index
0.81
31
374
17
209
0.81
0.32
1.8
2.1
0.67
1.77
u/field
—
9
109
21
174
1.21
0.31
1.1
1.3
—
—
—
0
0
622
6384
0.97
0.31
2.5
2.5
—
—
—
0
0
18
147
1.23
0.30
1.1
1.1
—
—
—
0
0
15
120
1.25
0.30
2.6
3.9
—
—
—
0
0
63
572
1.10
0.30
1.7
1.7
260.16
313.78
mu/l
1.20
55
528
33
288
1.15
0.29
1.2
1.4
6.85
6.43
mmol/l
0.51
33
274
8
62
1.29
0.28
1.0
1.0
—
—
—
0
0
1116
10993
1.03
0.26
13.3
12.1
0.00
0.00
e9/l
2.34
916
8971
23
197
1.17
0.25
1.3
1.4
12.70
13.39
u/l
0.28
23
188
12
149
0.80
0.25
2.8
1.7
—
—
—
0
0
51
463
1.10
0.25
1.2
1.8
—
—
—
0
0
110
1034
1.07
0.25
4.1
3.4
90.05
1614.97
u/ml
0.95
91
895
239
2486
0.96
0.25
7.8
7.3
1.40
1.34
mmol/l
0.26
234
2444
44
486
0.90
0.24
1.1
1.3
49.73
35.50
u/l
0.25
37
417
18
212
0.85
0.24
1.5
1.2
—
—
—
0
0
849
8346
1.03
0.24
2.5
2.6
—
—
—
0
0
18
152
1.19
0.23
2.7
2.6
39.22
40.83
%
—
9
84
31
349
0.89
0.23
3.4
5.3
347.42
352.42
umol/l
0.05
24
307
228
2193
1.04
0.23
2.7
2.5
0.69
0.47
e6/l
0.43
214
2097
12
147
0.82
0.23
1.1
1.1
—
—
—
0
0
11
88
1.25
0.22
2.4
2.4
0.64
0.61
mmol/l
0.92
11
88
13
107
1.22
0.21
1.0
1.1
1525.69
1600.52
miu/ml
0.09
13
107
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
313.10
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
86
915
0.94
0.21
1.4
1.6
0.39
0.33
mg/l
0.28
36
424
8
101
0.79
0.21
1.1
1.2
17.50
10.10
mm/h
—
8
101
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
40.48
—
0
13
0
14
0.00
0.20
0.0
1.1
—
0.02
—
0
5
26
291
0.89
0.19
1.8
1.7
—
—
—
0
0
6
52
1.15
0.19
1.3
1.2
—
—
—
0
0
251
2434
1.03
0.19
1.6
1.5
—
—
—
0
0
7
58
1.21
0.18
1.6
1.5
—
—
—
0
0
7
58
1.21
0.18
5.3
3.9
—
—
—
0
0
31
341
0.91
0.17
1.3
1.3
—
—
—
0
0
22
195
1.13
0.17
2.1
2.4
816.83
633.81
ml
0.85
12
134
29
262
1.11
0.17
1.7
1.5
—
—
—
0
0
46
496
0.93
0.17
1.8
1.6
—
—
—
0
0
13
110
1.18
0.17
2.9
4.1
—
—
—
0
0
38
413
0.92
0.17
1.3
1.2
303.95
266.22
u/ml
0.35
20
234
5
67
0.75
0.17
1.6
1.3
27.20
28.35
s
—
5
67
45
485
0.93
0.17
1.1
1.2
—
—
—
0
0
90
946
0.95
0.16
2.2
2.0
20.67
21.30
s
0.89
73
850
43
398
1.08
0.16
1.5
1.4
116.87
157.48
au/ml
—
8
112
17
149
1.14
0.15
1.2
1.2
—
—
—
0
0
27
245
1.10
0.15
1.1
1.1
—
—
—
0
0
9
79
1.14
0.15
1.1
1.9
—
—
—
0
0
31
338
0.92
0.15
5.2
2.3
1.06
1.25
g/24h
0.21
17
200
9
82
1.10
0.15
1.7
1.6
69.89
421.05
nmol/24h
—
9
82
7
90
0.78
0.14
1.4
2.1
0.00
0.03
estimate
—
7
90
15
131
1.15
0.14
1.9
1.6
—
—
—
0
0
207
2014
1.03
0.14
2.2
2.9
6.00
6.05
ph
0.42
139
1376
430
4226
1.02
0.14
3.6
3.2
1.97
2.56
e6/l
1.28
204
2092
14
159
0.88
0.13
1.5
2.3
15.16
16.37
%
0.79
14
159
19
211
0.90
0.13
1.1
1.1
—
—
—
0
0
19
211
0.90
0.13
1.0
1.0
847.46
698.90
ng/l
0.46
13
137
9
106
0.85
0.13
18.4
12.9
0.59
0.64
mmol/l
—
9
98
16
142
1.13
0.12
1.4
1.2
138.56
136.92
nmol/l
0.05
16
142
31
287
1.08
0.12
1.2
1.1
6.36
2.21
eliau/ml
0.35
12
111
19
210
0.90
0.12
1.0
1.0
332.83
309.65
ng/l
0.13
12
140
158
1623
0.97
0.11
1.4
1.4
—
—
—
0
0
52
494
1.05
0.11
1.2
1.7
—
—
—
0
0
43
406
1.06
0.11
1.2
1.1
—
—
—
0
0
18
163
1.11
0.10
1.7
1.5
163.00
82.58
umol/l
0.44
18
163
63
603
1.05
0.10
3.4
3.4
13186.25
750.60
u/ml
0.52
55
557
52
495
1.05
0.10
1.2
1.8
—
—
—
0
0
42
397
1.06
0.10
1.1
1.1
117.17
63.15
iu/ml
—
9
81
27
290
0.93
0.10
1.7
1.6
—
—
—
0
0
52
496
1.05
0.10
1.2
1.8
—
—
—
0
0
37
349
1.06
0.10
1.4
1.4
1282.15
4201.02
e6/l
0.60
26
240
5
46
1.09
0.09
1.2
1.4
—
—
—
0
0
129
1324
0.97
0.09
1.4
1.8
1.62
1.55
g/l
0.37
103
1153
5
48
1.04
0.09
1.2
1.1
—
—
—
0
0
52
498
1.05
0.08
1.2
1.7
—
—
—
0
0
6
56
1.07
0.08
1.8
1.6
—
—
—
0
0
17
156
1.09
0.08
1.2
1.3
7.44
7.41
ph
0.36
12
104
32
303
1.06
0.07
1.5
1.4
30075.13
95785.08
e6/l
1.19
15
165
54
561
0.96
0.07
1.3
1.4
57.66
61.10
mmol/l
0.34
47
457
51
490
1.04
0.07
1.3
1.2
—
—
—
0
0
20
215
0.93
0.07
1.2
2.2
—
—
—
0
0
20
186
1.08
0.07
1.3
1.1
—
—
—
0
0
40
383
1.05
0.07
1.2
1.8
—
—
—
0
0
9
87
1.03
0.07
2.0
1.6
—
—
—
0
0
41
393
1.04
0.07
1.2
1.1
—
—
—
0
0
59
609
0.97
0.06
1.1
1.2
—
—
—
0
0
11
99
1.11
0.06
1.8
2.1
30.00
30.41
%
0.03
11
99
667
6626
1.01
0.06
1.4
1.4
—
—
—
0
0
33
345
0.96
0.06
1.2
1.3
—
—
—
0
0
69
672
1.03
0.05
2.4
2.3
124.45
128.75
g/l
0.77
56
528
32
306
1.05
0.05
2.8
2.2
—
—
—
0
0
18
192
0.94
0.05
1.1
1.1
31.11
33.90
mmol/l
0.33
18
172
555
5515
1.01
0.05
3.1
3.1
2.46
2.46
mmol/l
0.21
484
4984
32
307
1.04
0.05
1.5
1.4
285.67
275.14
mosm/kgh2o
0.97
24
231
465
4622
1.01
0.04
3.4
3.0
0.97
1.22
e6/l
0.95
244
2497
11
101
1.09
0.04
1.8
2.0
8.73
7.70
%
0.19
11
96
291
2929
0.99
0.03
1.6
1.6
—
—
—
0
0
76
748
1.02
0.03
15.6
10.2
—
—
—
0
0
99
978
1.01
0.02
1.7
1.8
—
—
—
0
0
35
341
1.03
0.02
1.2
1.2
1.87
4.70
u/ml
2.30
15
151
66
650
1.02
0.02
1.2
1.2
1.58
1.56
g/l
0.29
66
650
68
670
1.02
0.02
1.3
1.2
—
—
—
0
0
25
258
0.97
0.02
1.1
1.2
—
—
—
0
0
99
999
0.99
0.01
2.3
2.2
268.06
694.23
ug/l
1.30
93
951
19
197
0.96
0.01
4.1
2.7
18.42
31.81
mg/l
1.99
12
146
60
592
1.01
0.01
1.1
1.1
0.52
0.65
ratio
2.01
13
85
60
607
0.99
0.01
2.8
2.4
57.65
61.15
%
0.58
60
602
89
891
1.00
0.00
2.7
3.2
292.79
345.63
mg/l
0.16
38
369
12
124
0.97
0.00
1.7
1.3
282.12
317.06
u/l
0.10
12
112
248
2485
1.00
0.00
9.9
7.2
10.36
10.12
mmol/l
0.20
234
2386
21
206
1.02
0.00
1.2
1.1
—
—
—
0
0
24
244
0.98
0.00
2.2
2.3
—
—
—
0
0
14
138
1.01
0.00
1.2
1.1
14.41
16.29
u/ml
—
7
59
62
624
0.99
0.00
1.3
1.2
—
—
—
0
0
29
292
0.99
0.00
1.6
1.5
—
—
—
0
0
505
5048
1.00
0.00
3.4
3.0
496.73
522.87
mosm/kgh2o
2.28
454
4440
34
343
0.99
0.00
2.4
2.3
21.34
22.08
mg/l
0.04
15
125
0
5
0.00
-0.00
0.0
1.2
—
1270.00
—
0
5
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.0
—
—
—
0
0
8
81
0.99
-0.00
1.3
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.08
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
27.72
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
236.63
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
58
0.86
-0.00
1.4
1.2
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
179.80
—
0
5

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_CHOROID and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CHOROID 0.835 [0.74, 0.94] 0.002
Birth year 0.994 [0.98, 1.0] 0.195

During the follow-up period (1.1.1998 — 31.12.2019), 842 out of 5914 females with CD2_BENIGN_CHOROID died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_CHOROID 0.838 [0.73, 0.97] 0.016
Birth year 0.989 [0.98, 1.0] 0.023

During the follow-up period (1.1.1998 — 31.12.2019), 654 out of 3580 males with CD2_BENIGN_CHOROID died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CHOROID.

N-year risk Females Males
1 0.083% 0.147%
5 0.466% 1.013%
10 1.192% 2.645%
15 2.354% 4.999%
20 4.394% 8.679%

Relationships between endpoints

Index endpoint: CD2_BENIGN_CHOROID – Benign neoplasm: Choroid

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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