Hodgkins lymphoma: Hodgkin lymphoma (HL) is a heterogeneous group of malignant lymphoid neoplasms of B-cell origin characterized histologically by the presence of Hodgkin and Reed-Sternberg (HRS) cells in the vast majority of cases. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
777 |
4. Check minimum number of eventsNone |
777 |
5. Include endpointsNone |
777 |
6. Filter based on genotype QC (FinnGen only) |
700 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L98
- Name in latin
- Granuloma pyogenicum
Similar endpoints
↥List of similar endpoints to
Pyogenic granuloma
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue, not elsewhere classified
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4805 | 2431 | 2340 |
| Only index persons | 4301 | 2212 | 2089 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 42.38 | 42.80 | 41.78 |
| Only index persons | 43.15 | 42.91 | 43.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 700 | 396 | 304 |
| Unadjusted period prevalence (%) | 0.14 | 0.14 | 0.14 |
| Median age at first event (years) | 53.04 | 47.30 | 60.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 725
- Matched controls
- 7250
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L98.0
ICD-10 Finland
Pyogenic granuloma
4503599627370496.0
307.7
698
*
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
44.1
94.9
57
14
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.7
80.0
145
262
ZXC10
NOMESCO Finland
Use of laser
8.9
39.0
50
60
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
8.4
34.5
46
58
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
11.1
28.8
31
29
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
24.3
26.3
37
16
ZXC50
NOMESCO Finland
Cryotherapy
6.3
22.7
39
65
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
9.1
22.5
28
32
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
3.5
19.8
72
221
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
6.9
19.3
30
45
ZXC07
NOMESCO Finland
Carbon dioxide laser
102.7
18.6
20
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
5.6
17.8
34
63
XQ848
NOMESCO Finland
Dermatological photography
5.1
16.8
36
74
6861A
ICD-9 Finland
Other local infections of skin and subcutaneous tissue, Pyogenic granuloma
+∞
16.7
16
*
D18.0
ICD-10 Finland
Haemangioma, any site
4.9
15.3
34
72
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
4.4
13.2
33
77
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.7
12.7
41
116
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.9
12.1
59
216
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.6
11.9
71
289
68610
ICD-8 Finland
Other local infections of skin and subcutaneous tissue, Granuloma pyogenicum
+∞
11.5
11
*
J01DB01
ATC
cefalexin; oral
1.9
10.4
598
5136
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.3
10.1
81
377
S18
ICPC
Laceration/cut
1.7
10.0
328
2406
S04
ICPC
Lump/swelling localized
2.2
10.0
94
468
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
9.9
88
428
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
26.4
9.8
13
5
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
30.5
9.4
12
*
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
22.0
9.4
13
6
E0000UV, ,
ATC
1.6
8.9
291
2119
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.8
8.7
155
959
C08CA01
ATC
amlodipine; oral
1.6
8.5
240
1679
QCA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of upper limb
27.9
8.5
11
*
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
4.8
8.1
18
38
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
22.3
8.0
11
5
A46
ICD-10 Finland
Erysipelas
2.0
8.0
95
515
TQW99
NOMESCO Finland
Other minor procedure on skin
2.9
7.9
38
138
L03.9
ICD-10 Finland
Cellulitis, unspecified
4.7
7.9
18
39
L89
ICD-10 Finland
Decubitus ulcer and pressure area
13.2
7.9
13
10
D02AX
ATC
Other emollients and protectives
3.3
7.7
28
86
A28
ICPC
Limited function/disability NOS
1.8
7.7
117
687
XQ845
NOMESCO Finland
Dermatoscopy
4.6
7.7
18
40
NHQ40
NOMESCO Finland
Amputation of toe
9.0
7.6
15
17
S21
ICPC
Skin texture symptom/complaint
1.8
7.5
111
647
E000001, ,
ATC
1.7
7.5
140
875
E000003, ,
ATC
2.8
7.4
37
138
ZZR00
NOMESCO Finland
Flap of skin
4.2
7.3
19
46
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
5.9
7.3
19
33
S97
ICPC
Chronic ulcer skin
2.6
7.2
41
163
L04AA06
ATC
mycophenolic acid; systemic
4.6
7.2
17
38
ZZA00
NOMESCO Finland
Split skin graft
3.6
7.2
23
65
J01FF01
ATC
clindamycin; systemic
1.6
7.2
178
1199
L30.3
ICD-10 Finland
Infective dermatitis
3.1
7.2
30
101
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
20.2
7.1
10
5
J01CF05
ATC
flucloxacillin; systemic
2.2
7.1
58
272
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.4
7.0
47
202
ZXE00
NOMESCO Finland
One hour or less
1.5
6.9
260
1928
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
3.7
6.8
21
58
Z2221
NOMESCO Finland
Medical doctor
1.6
6.7
186
1283
DHB10
NOMESCO Finland
Excision of lesion of internal nose
12.4
6.6
11
9
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
10.1
6.5
12
12
S29
ICPC
Skin symptom/complaint other
1.7
6.5
137
883
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
4.0
6.5
18
46
D07AC13
ATC
mometasone; topical
1.6
6.4
188
1314
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.4
244
1810
ZXA05
NOMESCO Finland
Left side
1.6
6.3
151
1004
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.3
6.3
45
200
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
2.2
6.1
48
223
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
6.0
142
941
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
340
2557
1.62
9.16
6.8
4.9
35.63
36.12
g/l
0.86
326
2415
224
1607
1.57
6.90
2.8
2.3
2.86
2.80
mg/l
0.14
205
1383
430
3589
1.49
6.23
6.0
4.9
6.80
6.57
mmol/l
1.10
401
3352
382
3116
1.48
6.21
4.2
3.1
100.95
106.95
ug/l
0.34
366
2920
139
913
1.65
6.09
2.7
2.4
2.41
2.33
g/l
0.71
134
843
241
1800
1.51
6.03
2.3
2.1
128.15
237.57
u/l
2.21
231
1716
70
380
1.93
5.86
4.1
3.1
162.28
208.12
ng/l
0.47
62
343
661
6119
1.91
5.84
20.4
14.3
24.55
23.18
mg/l
0.45
560
4984
203
1473
1.53
5.79
3.0
2.7
343.97
343.15
umol/l
0.04
183
1315
223
1652
1.51
5.76
3.3
3.2
1825.79
1172.30
ng/l
1.07
186
1391
334
2680
1.46
5.76
21.6
12.9
1.32
1.22
inr
2.31
291
2218
326
2606
1.46
5.72
2.1
2.1
92.59
95.36
pmol/l
0.44
168
1404
423
3553
1.46
5.70
10.5
9.6
4.14
4.11
e9/l
0.09
372
3075
584
5243
1.59
5.63
26.3
17.8
13.68
13.53
%
1.84
577
5192
357
2912
1.45
5.58
3.6
2.8
—
—
estimate
—
0
0
339
2753
1.43
5.35
2.8
2.5
75.61
75.31
nmol/l
0.07
314
2505
103
650
1.68
5.24
6.3
8.1
5.05
5.07
kpa
0.05
97
625
524
4622
1.48
5.24
9.7
7.7
80.44
78.51
u/l
0.37
496
4387
474
4103
1.45
5.21
5.5
4.4
1047.50
831.23
e6/l
—
6
65
102
643
1.68
5.21
6.2
8.3
1.25
0.92
mmol/l
0.31
87
537
103
651
1.68
5.21
6.2
8.1
12.61
12.33
kpa
0.14
97
629
120
792
1.62
5.12
7.3
7.4
104.32
104.49
mmol/l
0.13
120
792
147
1022
1.55
5.03
3.2
3.5
0.81
0.82
mmol/l
0.31
136
977
360
2981
1.41
4.97
8.8
7.1
1.21
1.21
mmol/l
0.94
321
2594
121
807
1.60
4.94
7.7
5.5
1.08
1.04
mmol/l
0.84
114
753
610
5582
1.59
4.88
6.8
5.9
39.61
38.80
mmol/mol
1.32
582
5265
17
52
3.32
4.77
1.4
1.8
—
—
—
0
0
679
6406
1.94
4.68
13.9
11.0
27.28
26.43
u/l
0.63
662
6244
91
587
1.63
4.26
5.8
4.1
2.15
1.76
mmol/l
0.48
77
495
393
3359
1.37
4.22
4.5
3.7
0.00
4.96
estimate
0.80
82
706
29
129
2.30
4.11
2.1
1.6
—
—
—
0
0
700
6712
2.24
4.03
31.2
21.9
253.21
251.05
e9/l
0.37
691
6589
700
6712
2.24
4.03
30.9
21.8
90.40
90.65
fl
0.80
694
6648
700
6714
2.24
3.99
31.5
22.3
40.20
40.57
%
1.26
694
6645
700
6714
2.24
3.99
31.1
21.8
4.49
4.52
e12/l
1.23
688
6581
322
2683
1.36
3.99
8.1
6.4
1.20
1.21
mmol/l
1.85
301
2496
193
1479
1.42
3.97
4.3
3.6
1.02
1.02
kg/l
0.10
135
978
182
1381
1.42
3.96
1.8
1.7
—
—
—
0
0
388
3330
1.36
3.95
4.5
3.7
0.00
0.00
estimate
0.50
82
698
14
43
3.30
3.92
2.6
3.4
687.14
1054.91
mg
0.66
14
43
700
6718
2.22
3.91
31.2
22.0
133.98
135.92
g/l
2.87
694
6653
266
2161
1.36
3.84
3.0
3.1
31.23
32.18
u/l
0.22
253
2054
240
1919
1.37
3.82
3.5
2.6
53.15
62.88
u/l
1.87
220
1802
67
412
1.69
3.78
2.0
1.6
—
—
—
0
0
652
6139
1.62
3.73
23.7
16.4
139.66
139.66
mmol/l
0.01
641
6016
391
3386
1.34
3.63
4.6
3.7
0.04
0.46
estimate
0.46
80
670
125
904
1.46
3.49
1.7
1.7
1118.36
1174.61
nmol/l
0.28
100
709
651
6148
1.58
3.43
24.0
16.5
3.95
3.96
mmol/l
0.03
638
6009
72
463
1.62
3.43
5.6
4.0
87.37
80.84
ng/l
0.28
63
413
75
490
1.59
3.35
1.6
1.6
1079.62
982.43
mu/l
0.51
64
419
177
1375
1.38
3.31
3.2
2.5
6.48
6.38
e6/l
0.02
163
1243
148
1117
1.41
3.28
4.6
3.7
251.11
400.06
ng/l
0.50
118
809
610
5698
1.44
3.26
5.8
5.1
1.89
1.87
mu/l
0.16
580
5295
92
636
1.51
3.21
2.5
2.0
387.77
386.90
nmol/l
0.02
87
594
77
512
1.56
3.20
4.5
3.8
4.42
4.60
kpa
0.47
72
497
43
719
0.57
3.20
4.9
4.5
29.97
31.59
%
0.49
32
486
14
51
2.78
3.00
1.6
1.5
—
—
—
0
0
244
2017
1.32
2.98
3.9
3.2
2.36
2.35
mmol/l
0.28
228
1837
250
2078
1.31
2.93
4.2
3.4
7.49
8.06
mmol/l
1.18
220
1775
228
1876
1.31
2.86
5.2
4.1
12.31
8.32
mg/mmol
0.72
163
1175
525
4825
1.32
2.80
4.7
4.2
14.50
14.68
pmol/l
1.07
490
4433
673
6452
1.60
2.75
26.3
18.1
78.79
75.57
umol/l
1.76
668
6381
635
6019
1.44
2.71
5.7
5.3
2.59
2.73
mmol/l
3.66
597
5643
361
3171
1.28
2.70
7.1
6.2
11.77
11.35
umol/l
0.34
342
3023
66
443
1.54
2.66
2.6
2.5
57.42
70.18
ml/min/173m2
1.59
26
185
12
43
2.82
2.65
1.4
1.6
—
—
—
0
0
12
43
2.82
2.65
1.4
1.6
—
—
—
0
0
12
43
2.82
2.65
1.4
1.6
—
—
—
0
0
102
748
1.42
2.65
1.9
1.8
—
—
—
0
0
39
230
1.74
2.61
1.7
1.9
1.04
2.86
ug/l
0.72
34
202
7
15
4.70
2.60
2.4
1.6
0.59
0.60
mmol/l
—
7
15
52
333
1.60
2.57
1.5
1.5
—
—
—
0
0
144
1125
1.35
2.56
3.5
2.8
2.45
2.44
mmol/l
0.14
129
1008
206
1703
1.29
2.45
1.7
1.6
20.20
20.15
nmol/l
0.02
184
1444
83
596
1.44
2.43
3.6
3.1
—
—
—
0
0
97
717
1.41
2.42
3.4
2.6
10.01
7.64
umol/l
0.38
88
627
96
709
1.41
2.41
2.0
1.8
—
—
—
0
0
626
5945
1.39
2.40
5.2
4.7
4.46
4.62
mmol/l
3.75
592
5592
293
2540
1.26
2.35
4.4
3.5
0.00
0.03
estimate
1.95
70
590
225
1891
1.28
2.34
4.0
3.1
0.00
0.06
estimate
0.77
68
570
46
293
1.61
2.34
1.7
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
28
157
1.81
2.24
3.4
2.6
0.28
0.41
iu/ml
1.29
15
79
128
1006
1.33
2.19
2.1
1.8
—
—
—
0
0
27
151
1.82
2.19
1.8
1.5
—
—
—
0
0
492
4549
1.25
2.14
4.8
4.1
13.75
10.98
mm/h
3.14
473
4259
620
5908
1.34
2.07
5.0
4.7
1.41
1.45
mmol/l
1.76
583
5530
133
1060
1.31
2.06
3.7
2.9
0.91
0.89
e6/l
0.03
75
549
465
4283
1.24
2.04
3.4
3.3
48.13
44.87
u/l
0.33
441
4074
27
155
1.77
2.03
1.7
1.5
—
—
—
0
0
33
201
1.67
2.02
2.0
1.7
—
—
—
0
0
235
2022
1.24
1.95
4.6
3.2
33.75
87.77
e6/l
0.92
191
1535
150
1227
1.28
1.91
1.9
1.7
439.00
26978508.56
pmol/l
1.20
125
1049
30
181
1.69
1.91
1.6
1.5
54.03
55.11
ug/l
0.04
30
181
59
417
1.45
1.91
2.2
2.4
4.08
8.41
ug/l
1.95
51
366
14
65
2.18
1.89
1.7
1.3
—
—
—
0
0
125
1003
1.30
1.85
4.3
3.1
3.14
2.29
e6/l
0.47
65
492
25
145
1.75
1.83
1.4
1.4
—
—
—
0
0
7
23
3.06
1.80
1.0
1.0
—
—
—
0
0
36
232
1.58
1.79
1.7
1.7
—
—
—
0
0
203
1735
1.24
1.77
4.2
3.1
0.61
0.41
e6/l
0.48
160
1254
27
163
1.68
1.73
1.6
1.5
—
—
—
0
0
22
125
1.78
1.73
1.4
1.4
—
—
—
0
0
604
5770
1.28
1.71
5.5
4.7
5.97
5.89
mmol/l
0.75
572
5330
34
219
1.58
1.71
2.6
1.6
—
—
—
0
0
25
150
1.69
1.65
1.5
1.3
—
—
—
0
0
139
1152
1.26
1.60
1.4
1.3
17.87
29.37
iu/ml
1.23
42
349
31
200
1.57
1.56
2.2
2.3
3.62
3.61
g/l
0.02
31
194
211
1833
1.21
1.56
5.2
5.3
2.03
2.38
ug/l
0.48
192
1660
35
234
1.52
1.52
1.4
1.3
—
—
—
0
0
178
1524
1.22
1.52
3.1
2.3
—
—
—
0
0
54
394
1.40
1.51
3.9
3.6
4.38
4.61
pmol/l
1.17
44
354
9
37
2.45
1.48
1.3
1.5
184.76
185.50
pmol/l
—
9
37
9
38
2.39
1.46
2.6
3.1
0.56
0.92
index
—
9
38
7
28
2.51
1.45
1.0
1.9
53.04
92.88
ng/l
—
7
28
22
133
1.67
1.44
1.4
1.2
—
—
—
0
0
20
120
1.69
1.35
1.5
1.4
—
—
—
0
0
31
208
1.51
1.35
1.9
2.5
3.36
3.79
g/l
1.28
31
195
9
42
2.16
1.34
3.7
1.9
—
—
—
0
0
27
176
1.55
1.33
1.4
1.2
—
—
—
0
0
34
235
1.47
1.29
1.6
1.4
8.36
8.48
u/l
0.02
28
186
8
34
2.37
1.29
1.5
1.5
5.14
6.25
mmol/l
—
8
34
170
1473
1.20
1.28
4.2
4.3
22.03
21.24
%
0.25
75
680
108
895
1.24
1.26
3.0
2.6
212.60
114.53
ug/g
1.03
91
711
35
245
1.45
1.26
2.0
1.8
22.80
9.05
iu/ml
—
5
47
23
147
1.58
1.24
1.0
2.7
0.00
0.00
g/l
-0.00
23
140
18
108
1.68
1.23
4.8
2.7
9.30
8.37
pmol/l
0.14
18
108
58
445
1.33
1.23
4.9
3.6
1.23
1.23
mmol/l
0.43
48
383
70
552
1.30
1.22
3.1
2.5
11.33
12.94
nmol/l
0.85
64
503
26
173
1.52
1.19
4.7
4.7
24.96
85.80
mg/l
1.11
21
150
6
26
2.32
1.19
1.8
1.6
—
—
—
0
0
6
26
2.32
1.19
1.8
1.6
—
—
—
0
0
6
26
2.32
1.19
1.8
1.6
—
—
—
0
0
6
26
2.32
1.19
1.8
1.6
—
—
—
0
0
161
1400
1.19
1.17
1.8
1.7
1.05
1.25
mg/l
0.72
127
1083
26
174
1.51
1.17
1.2
1.1
—
—
—
0
0
251
2266
1.16
1.16
4.3
3.5
26.91
61.01
ng/l
0.70
179
1522
0
34
0.00
1.16
0.0
1.3
—
8.53
—
0
34
0
34
0.00
1.16
0.0
1.1
—
—
—
0
0
126
1072
1.21
1.15
1.3
1.3
15.00
11.37
u/ml
0.21
50
402
175
1542
1.18
1.09
5.3
3.8
88.48
90.63
%
0.51
170
1515
47
357
1.34
1.08
1.7
1.6
—
—
—
0
0
7
32
2.20
1.08
1.6
1.7
—
—
—
0
0
36
263
1.39
1.06
1.5
1.5
1.38
1.19
ratio
0.65
20
171
36
263
1.39
1.06
1.5
1.5
0.91
0.94
ratio
0.37
20
171
36
263
1.39
1.06
1.5
1.5
1.20
1.20
ratio
0.00
20
171
7
33
2.13
1.05
1.6
1.7
—
—
—
0
0
449
4250
1.15
1.04
3.6
3.3
—
—
—
0
0
205
1839
1.16
1.02
4.2
3.7
0.00
0.01
estimate
0.99
79
659
9
49
1.85
0.99
1.0
1.2
—
—
—
0
0
9
50
1.81
0.97
1.0
1.2
—
—
—
0
0
581
5616
1.17
0.96
4.5
4.0
1.28
1.27
mmol/l
0.07
543
5216
38
286
1.35
0.95
1.6
1.6
108.92
62.64
ug/l
0.68
33
246
7
37
1.90
0.94
1.6
1.6
—
—
—
0
0
177
1581
1.16
0.93
1.4
1.3
0.66
1.87
u/ml
2.54
50
451
60
483
1.26
0.93
1.1
1.3
102.50
155.03
u/ml
0.59
22
189
35
261
1.36
0.93
1.5
1.5
—
—
—
0
0
13
78
1.68
0.92
1.9
1.6
—
—
—
0
0
25
176
1.44
0.91
1.2
1.1
—
—
—
0
0
56
451
1.26
0.88
1.3
1.4
—
—
—
0
0
8
43
1.87
0.87
1.0
1.5
—
—
—
0
0
15
96
1.57
0.85
1.5
1.5
—
—
—
0
0
24
171
1.42
0.84
1.3
1.4
303.65
282.63
ug/g
0.31
14
100
20
284
0.70
0.83
1.4
1.3
169.90
245.72
miu/ml
—
10
138
45
357
1.28
0.80
5.6
3.9
0.89
1.86
mmol/l
0.90
37
265
18
122
1.49
0.80
1.9
1.5
—
—
—
0
0
6
33
1.82
0.79
1.2
1.9
—
—
—
0
0
6
33
1.82
0.79
1.2
1.9
—
—
—
0
0
12
74
1.63
0.78
2.8
1.5
31.25
33.14
pg
0.82
12
74
597
5810
1.16
0.77
20.4
13.6
82.57
85.10
ml/min/173m2
1.82
550
5314
9
55
1.64
0.73
2.8
2.9
13.11
13.50
index
—
9
38
44
354
1.26
0.72
1.7
1.4
20.17
22.12
iu/l
0.15
37
299
7
41
1.71
0.70
1.0
1.3
—
—
—
0
0
5
91
0.55
0.67
1.6
1.1
—
2.02
—
0
18
25
189
1.33
0.65
2.2
2.9
—
—
—
0
0
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
5
29
1.73
0.64
1.4
1.2
14.80
15.71
u/l
—
5
24
0
20
0.00
0.60
0.0
3.7
—
10.17
—
0
20
0
20
0.00
0.60
0.0
3.6
—
4.59
—
0
20
0
21
0.00
0.60
0.0
1.4
—
81.59
—
0
21
8
52
1.54
0.59
1.5
1.8
—
—
—
0
0
8
52
1.54
0.59
2.0
1.4
—
—
—
0
0
7
116
0.60
0.58
1.1
1.3
—
—
—
0
0
6
36
1.67
0.56
1.3
1.5
—
—
—
0
0
21
160
1.32
0.54
4.7
4.3
0.98
2.79
ratio
2.11
12
91
9
61
1.48
0.54
2.9
3.5
2.04
3.46
nmol/l
—
9
61
14
100
1.41
0.52
1.9
1.7
—
—
—
0
0
9
64
1.41
0.51
1.7
2.7
25.94
24.07
nmol/l
—
9
58
6
41
1.47
0.50
1.0
1.1
—
—
—
0
0
19
145
1.32
0.49
1.9
1.5
15278.00
14967.41
e6/l
0.02
14
107
29
235
1.24
0.49
1.8
1.6
40.27
7.45
u/ml
—
6
56
7
46
1.53
0.48
2.0
1.6
—
—
—
0
0
42
355
1.19
0.48
2.4
2.4
6312.16
5900.76
u/l
0.03
19
157
64
562
1.15
0.47
1.7
1.7
3.43
3.43
mmol/l
0.01
38
403
10
69
1.46
0.44
2.2
2.8
1.20
1.19
mmol/l
—
10
69
26
211
1.24
0.44
1.5
1.4
—
—
—
0
0
19
148
1.29
0.44
1.4
1.2
—
—
—
0
0
5
31
1.62
0.43
6.2
2.7
605.00
631.65
u/ml
—
5
31
5
31
1.62
0.43
1.4
1.2
72.80
77.50
u/l
—
5
26
30
249
1.21
0.42
1.2
1.1
0.88
0.87
g/l
0.02
30
249
263
2507
1.08
0.42
2.0
1.9
1.35
1.35
mmol/l
0.03
223
2156
10
70
1.43
0.42
2.2
2.8
102.60
105.71
mmol/l
—
10
70
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
7.81
—
0
10
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
17
132
1.29
0.40
1.8
2.4
392.80
73.19
ug/min
0.61
11
74
5
34
1.47
0.40
7.4
1.9
27.60
29.62
umol/l
—
5
29
73
656
1.13
0.40
2.5
2.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
357.82
—
0
11
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
8
61
1.31
0.39
1.5
1.7
—
—
—
0
0
21
169
1.25
0.39
1.4
1.3
—
—
—
0
0
22
179
1.24
0.37
2.0
2.0
213.05
221.40
pmol/l
0.08
22
166
5
37
1.35
0.37
1.8
1.4
5.90
7.01
u/l
—
5
28
9
71
1.27
0.36
1.0
1.0
—
—
—
0
0
20
163
1.23
0.34
2.7
2.3
14.25
11.80
mg/l
0.49
20
151
11
82
1.35
0.34
2.2
1.6
—
—
—
0
0
17
136
1.26
0.34
1.9
1.6
0.70
0.95
nmol/l
1.07
17
114
27
229
1.19
0.32
1.1
1.1
0.66
0.66
ratio
—
6
23
12
92
1.31
0.32
1.5
1.5
6.75
7.30
mmol/l
0.40
12
78
7
97
0.72
0.31
2.9
6.0
290.14
379.90
umol/l
—
7
87
7
53
1.32
0.31
4.0
3.1
24.13
48.72
u/ml
—
7
53
21
176
1.20
0.29
1.2
1.1
2.17
3.34
u/ml
0.32
16
91
28
242
1.16
0.28
1.1
1.1
1.51
1.53
g/l
0.19
28
242
13
103
1.27
0.28
1.2
1.1
—
—
—
0
0
8
66
1.21
0.26
3.4
4.1
—
—
—
0
0
12
95
1.27
0.26
1.3
1.2
—
—
—
0
0
12
95
1.27
0.26
1.3
1.2
—
191.43
—
0
7
60
550
1.10
0.26
3.0
4.5
8.83
31.08
ug/l
0.86
46
459
80
745
1.08
0.25
2.0
1.9
3.60
3.51
ratio
0.22
57
581
22
189
1.17
0.24
1.0
1.1
1.18
9.04
eliau/ml
—
6
25
40
360
1.12
0.24
1.1
1.0
—
—
—
0
0
41
370
1.11
0.24
1.3
1.3
—
—
—
0
0
80
855
0.93
0.23
1.9
1.8
1.46
1.44
%
0.05
75
754
27
306
0.88
0.23
1.4
1.6
0.29
0.29
mg/l
—
10
142
5
39
1.28
0.23
3.2
1.5
79.80
76.31
umol/l
—
5
39
21
181
1.17
0.22
1.6
2.0
3.43
4.41
iu/l
—
10
74
63
584
1.09
0.22
2.7
2.4
30.63
33.48
u/l
0.38
51
487
31
276
1.13
0.22
2.3
2.1
36.38
39.72
u/l
0.38
26
248
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
18
154
1.17
0.21
1.2
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
1.18
—
0
13
47
433
1.09
0.19
2.4
2.4
40.21
17.45
au/ml
—
7
35
15
127
1.18
0.19
1.5
1.5
0.22
0.35
nmol/l
1.05
15
103
115
1098
1.06
0.19
3.3
3.1
0.69
0.74
ug/l
0.40
72
695
6
52
1.16
0.19
1.0
1.2
—
—
—
0
0
15
128
1.18
0.18
1.5
1.7
—
—
—
0
0
7
59
1.19
0.18
1.6
1.2
50.00
52.76
u/l
—
7
52
7
59
1.19
0.18
1.0
1.2
—
—
—
0
0
7
60
1.17
0.18
1.0
1.6
—
—
—
0
0
7
63
1.11
0.17
1.0
1.2
—
—
—
0
0
5
68
0.73
0.17
1.0
1.1
—
—
—
0
0
8
71
1.13
0.16
1.5
1.2
—
—
—
0
0
9
78
1.16
0.15
1.3
1.4
321.78
367.70
pmol/l
—
9
70
9
79
1.14
0.15
2.1
1.8
13.54
13.10
%
—
9
79
22
200
1.10
0.12
2.2
1.5
1.19
1.22
g/l
0.22
22
189
13
114
1.14
0.12
1.2
1.3
—
—
—
0
0
13
114
1.14
0.12
1.2
1.3
—
—
—
0
0
60
629
0.95
0.12
10.1
6.0
—
—
—
0
0
95
982
0.96
0.11
2.5
2.1
—
—
—
0
0
6
54
1.11
0.09
1.0
1.2
—
—
—
0
0
6
54
1.11
0.09
1.0
1.2
—
—
—
0
0
6
58
1.03
0.08
1.0
1.1
—
—
—
0
0
24
224
1.07
0.08
2.5
1.8
—
—
—
0
0
18
195
0.92
0.08
1.3
1.3
—
—
—
0
0
14
127
1.10
0.08
1.0
1.1
14.86
14.32
au/ml
—
5
41
10
112
0.89
0.07
1.2
1.6
—
—
—
0
0
101
1034
0.97
0.07
1.4
1.5
—
—
—
0
0
21
196
1.07
0.07
2.2
1.5
0.23
0.24
g/l
0.17
21
188
7
84
0.83
0.07
1.4
1.2
—
—
—
0
0
10
110
0.91
0.05
1.3
1.4
31.62
22.02
u/l
—
10
90
105
1063
0.99
0.03
2.7
2.2
—
—
—
0
0
11
102
1.08
0.03
1.2
1.1
—
20.75
—
0
21
11
118
0.93
0.03
2.4
1.8
—
—
—
0
0
17
162
1.05
0.02
1.2
1.4
489.71
449.64
mg/l
0.12
17
154
10
93
1.08
0.02
1.6
1.3
—
—
—
0
0
12
114
1.05
0.00
2.7
2.0
3.99
5.08
mmol/24h
0.65
12
102
10
104
0.96
0.00
3.3
4.0
2955.56
2649.02
u/ml
—
10
99
19
194
0.98
0.00
1.3
1.5
—
—
—
0
0
21
214
0.98
0.00
2.6
1.7
—
—
—
0
0
14
142
0.99
0.00
1.1
1.3
3.38
3.69
mmol/l
0.83
14
133
25
252
0.99
0.00
1.7
1.8
—
—
—
0
0
11
109
1.01
0.00
1.1
1.0
6.76
2.27
eliau/ml
—
5
42
54
538
1.00
0.00
2.6
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
74
0.95
-0.00
2.3
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
11.66
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
71
0.99
-0.00
1.7
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
2.3
1.4
—
—
—
0
0
5
53
0.94
-0.00
1.8
1.6
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
5
49
1.02
-0.00
2.2
1.2
98.00
106.12
pmol/l
—
5
49
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
74
0.95
-0.00
2.3
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.2
—
—
—
0
0
7
70
1.00
-0.00
1.7
1.4
—
—
—
0
0
7
70
1.00
-0.00
1.7
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
8.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
65.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PYOGENGRANUL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYOGENGRANUL | 1.543 [1.27, 1.88] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.298 |
During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 1977 females with L12_PYOGENGRANUL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYOGENGRANUL | 1.421 [1.16, 1.73] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.039 |
During the follow-up period (1.1.1998 — 31.12.2019), 274 out of 1844 males with L12_PYOGENGRANUL died.
Mortality risk
Mortality risk for people of age
years, who have L12_PYOGENGRANUL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.179% | 0.302% |
| 5 | 1.04% | 1.5% |
| 10 | 2.355% | 4.318% |
| 15 | 4.488% | 8.409% |
| 20 | 7.648% | 14.355% |
Relationships between endpoints
↥Index endpoint: L12_PYOGENGRANUL – Pyogenic granuloma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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