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Thrombotic microangiopathy

DOID EFO Endpoint Browser PheWeb

M13_HTROMBMICROANG

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M31.1
  • Hospital discharge: ICD-9 — 4466
  • Hospital discharge: ICD-8 — 4464
  • Cause of death: ICD-10 — M31.1
  • Cause of death: ICD-9 — 4466
  • Cause of death: ICD-8 — 4464

2 out of 7 registries used, show all original rules.

248

4. Check minimum number of events

None

248

5. Include endpoints

None

248

6. Filter based on genotype QC (FinnGen only)

221

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M31
Name in latin
Microangiopathia thrombotica

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1214 706 498
Only index persons 1034 606 428
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 56.61 55.13 58.60
Only index persons 55.82 54.53 57.64

-FinnGen-

Key figures

All Female Male
Number of individuals 221 131 90
Unadjusted period prevalence (%) 0.04 0.05 0.04
Median age at first event (years) 54.64 52.68 57.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
231
Matched controls
2310
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
240.9
187
*
L04AX01
ATC
azathioprine; systemic
85.1
209.0
118
28
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
27.1
148.9
138
120
L04AA06
ATC
mycophenolic acid; systemic
87.2
126.4
68
11
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
108.0
95
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
61.2
56
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
12.1
59.4
70
80
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
58.9
54
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
12.3
58.2
67
74
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
29.1
56.1
39
16
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
15.3
51.2
49
40
L04AX03
ATC
methotrexate; systemic
9.9
51.0
70
97
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.6
50.5
160
528
M05BA04
ATC
alendronic acid; oral
9.6
49.1
69
98
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.2
47.6
53
55
ZX120
NOMESCO Finland
Intravenous
8.6
47.0
74
120
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
46.4
43
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
19.2
43.6
36
22
L01BA01
ATC
methotrexate; systemic
18.2
43.5
37
24
WW400
NOMESCO Finland
Plasmaferesis
+∞
40.9
38
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.9
38.7
50
63
H02AB06
ATC
prednisolone; systemic
6.7
38.6
177
756
L01AA01
ATC
cyclophosphamide; systemic
433.4
38.2
37
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
9.6
35.9
47
60
A11CC03
ATC
alfacalcidol; systemic
16.0
35.5
32
23
GD1AD
NOMESCO Finland
Thorax CT examination
9.4
35.4
47
61
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
90.2
35.0
38
5
H02AB07
ATC
prednisone; oral
6.3
34.6
73
157
P01BA02
ATC
hydroxychloroquine; oral
8.2
33.8
51
77
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
33.2
73
163
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
9.1
33.1
45
60
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.6
32.5
171
778
H02AB04
ATC
methylprednisolone; systemic
5.8
32.3
76
180
UDH02
NOMESCO Finland
Rhinopharyngoscopy
8.0
32.0
49
75
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
10.6
29.0
34
37
TPH04
NOMESCO Finland
Cathetrisation of vein
4.7
28.2
97
311
R50.9
ICD-10 Finland
Fever, unspecified
5.1
28.1
77
206
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
42.4
27.0
33
9
TK800
NOMESCO Finland
Hemodialysis
26.3
24.7
34
15
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
24.4
23
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
9.7
24.2
30
35
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
254.2
23.1
23
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.9
23.0
103
391
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.2
21.8
75
235
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.4
21.2
48
107
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.0
21.2
42
83
Z94.0
ICD-10 Finland
Kidney transplant status
36.4
20.7
26
8
WX892
NOMESCO Finland
Monitored bed care
6.3
20.5
38
70
B03XA02
ATC
darbepoetin alfa; parenteral
23.5
20.5
29
14
C08CA05
ATC
nifedipine; systemic
6.7
20.3
35
60
Z49.1
ICD-10 Finland
Extracorporeal dialysis
39.8
20.3
25
7
Z2446
NOMESCO Finland
Social worker
6.2
20.2
38
71
TPX10
NOMESCO Finland
Implantation of vascular injection port
8.4
19.5
27
36
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
7.2
19.4
31
49
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.3
19.0
35
64
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
19.0
18
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
19.0
18
*
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
19.0
18
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.6
18.9
52
136
127
Kela drug reimbursment
Transplant complication
22.3
18.2
26
13
C03CA01
ATC
furosemide; systemic
3.4
17.9
101
432
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
17.9
17
*
L04AD01
ATC
ciclosporin; systemic
31.7
17.8
23
8
ZX108
NOMESCO Finland
Inhalation
194.3
17.8
18
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.3
17.7
53
148
1XC02, ,
NOMESCO Finland
54.4
17.3
20
*
A12AA04
ATC
calcium carbonate; oral
24.2
17.3
24
11
N18.0
ICD-10 Finland
End-stage renal disease
38.3
17.0
21
6
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.6
16.9
46
119
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
16.9
16
*
L04AD02
ATC
tacrolimus; systemic
26.8
16.3
22
9
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
64.7
16.0
18
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
64.7
16.0
18
*
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
15.8
15
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
13.8
15.3
26
21
J01MA12
ATC
levofloxacin; systemic
3.4
15.2
71
267
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
34.3
15.1
19
6
XG410
NOMESCO Finland
Flow-volume spirometry
6.9
14.9
24
38
V03AE02
ATC
sevelamer; oral
85.7
14.8
16
*
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
14.7
14
*
J01MA14
ATC
moxifloxacin; systemic
4.3
14.6
42
113
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
29.4
14.5
19
7
N18.8
ICD-10 Finland
Other chronic renal failure
13.9
14.3
24
19
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.6
14.2
24
40
L04AA01
ATC
[U] ciclosporin
32.3
14.1
18
6
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
32.3
14.1
18
6
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
13.7
13
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
148.4
13.6
14
*
DHA10
NOMESCO Finland
Biopsy of cavity of nose
22.9
13.6
19
9
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
74.0
12.7
14
*
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
12.6
12
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
12.3
89
423
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
14.5
12.2
20
15
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.3
12.1
34
89
C09AA02
ATC
enalapril; systemic
3.0
12.1
67
275
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
10.5
12.1
23
24
C08CA02
ATC
felodipine; oral
4.1
12.0
36
99
RS221, ,
NOMESCO Finland
17.6
11.9
18
11
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.7
11.8
42
131
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.1
11.7
26
56
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
68.5
11.7
13
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
11.7
73
319
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
11.6
11
*
J01MA02
ATC
ciprofloxacin; systemic
2.5
11.0
114
640
TGC00
NOMESCO Finland
Bronchial lavation
8.7
10.9
23
29
A41.9
ICD-10 Finland
Sepsis, unspecified
8.4
10.7
23
30
Z3231
NOMESCO Finland
Registered nurse
2.6
10.6
86
428
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
10.5
10
*
H26.3
ICD-10 Finland
Drug-induced cataract
34.3
10.4
13
*
Z3226
NOMESCO Finland
Physiotherapist
2.8
10.4
64
276
B03XA01
ATC
erythropoietin; parenteral
24.7
10.4
14
6
R4110
NOMESCO Finland
Physiotherapy
2.6
10.3
89
455
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.4
10.3
27
67
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.6
10.3
88
448
Z49.2
ICD-10 Finland
Other dialysis
42.0
10.1
12
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.3
10.0
41
140
137
Kela drug reimbursment
Uraemia requiring dialysis
21.2
9.9
14
7
WX002
NOMESCO Finland
Sedation and analgesia
2.8
9.9
63
276
JN3AD
NOMESCO Finland
Abdominal CT examination
3.2
9.8
45
164
B07.9
ICD-10 Finland
Verruca simplex
5.2
9.7
21
44
J01FF01
ATC
clindamycin; systemic
2.5
9.7
81
405
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
9.8
9.7
19
21
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.6
9.6
34
105
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
8.6
9.6
20
25
TPH07
NOMESCO Finland
Cathetrisation of artery
3.3
9.5
40
138
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.9
9.5
22
49
V03AE01
ATC
polystyrene sulfonate; oral
18.5
9.5
14
8
6BA02, ,
NOMESCO Finland
104.1
9.5
10
*
A02BC02
ATC
pantoprazole; systemic
2.7
9.5
175
1248
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
9.4
9
*
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
9.4
9
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
9.4
9
*
205
Kela drug reimbursment
Chronic hypertension
2.5
9.2
75
370
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.4
9.2
36
119
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
9.1
63
287
JN4AD
NOMESCO Finland
Body CT examination
3.3
9.1
38
131
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
8.5
9.1
19
24
H04.10
ICD-10 Finland
Dry eye syndrome
3.1
9.0
42
154
B05DB
ATC
Hypertonic solutions
25.2
9.0
12
5
H02AB09
ATC
hydrocortisone; systemic
9.2
9.0
18
21
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.7
8.9
59
262
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
10.1
8.9
17
18
ZXA00
NOMESCO Finland
Right side
2.4
8.7
77
393
N05CD07
ATC
temazepam; oral
3.3
8.7
36
123
A02BC03
ATC
lansoprazole; oral
2.4
8.5
84
450
C08CA01
ATC
amlodipine; oral
2.3
8.4
107
638
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
8.4
8
*
4466A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Thrombotic microangiopathy
+∞
8.4
8
*
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
+∞
8.4
8
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
8.4
8
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
8.4
8
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
15.2
8.3
13
9
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.8
8.3
19
42
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.1
8.3
18
38
B05DA
ATC
Isotonic solutions
23.0
8.1
11
5
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
23.0
8.1
11
5
J31.0
ICD-10 Finland
Chronic rhinitis
3.4
8.1
31
101
WX203
NOMESCO Finland
Infraclavicular plexus blockade
8.2
8.0
17
22
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.1
8.0
23
61
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.1
8.0
35
124
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.4
7.9
18
26
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.6
7.9
27
81
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
6.3
7.9
20
34
A07AA02
ATC
nystatin; oral
3.8
7.8
25
72
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
46.6
7.8
9
*
M05BA07
ATC
risedronic acid; oral
7.1
7.8
18
27
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.3
7.7
31
104
M35.3
ICD-10 Finland
Polymyalgia rheumatica
12.4
7.7
13
11
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
9.3
7.7
15
17
Z49.0
ICD-10 Finland
Preparatory care for dialysis
26.0
7.6
10
*
A10AC01
ATC
insulin (human); parenteral
3.2
7.6
32
110
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
7.6
98
581
M13.9
ICD-10 Finland
Arthritis, unspecified
3.7
7.5
25
74
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
7.4
34
123
H65.2
ICD-10 Finland
Chronic serous otitis media
9.9
7.4
14
15
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
7.4
75
403
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
7.3
7
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.7
7.3
17
38
M05BX04
ATC
denosumab; parenteral
3.9
7.2
22
61
N02AX02
ATC
tramadol; systemic, rectal
2.1
7.2
111
702
TK810
NOMESCO Finland
Hemofiltration
31.1
7.2
9
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
31.1
7.2
9
*
Z2221
NOMESCO Finland
Medical doctor
2.2
7.2
80
446
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
10.5
7.1
13
13
J05AB11
ATC
valaciclovir; oral
2.5
7.1
50
228
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
7.0
58
284
UDM02
NOMESCO Finland
Sinoscopy
7.9
7.0
15
20
H65.3
ICD-10 Finland
Chronic mucoid otitis media
7.1
6.9
16
24
L88
ICPC
Rheumatoid/seropositive arthritis
6.0
6.9
18
32
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
9.8
6.9
13
14
M05BB03
ATC
alendronic acid and colecalciferol; oral
7.6
6.8
15
21
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
41.3
6.8
8
*
H15.0
ICD-10 Finland
Scleritis
41.3
6.8
8
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.3
6.8
18
45
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.9
6.7
34
130
ZXE00
NOMESCO Finland
One hour or less
2.1
6.7
104
654
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
6.7
45
200
XW000
NOMESCO Finland
Bone marrow biopsy
5.6
6.6
18
34
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.6
6.6
22
65
Z3229
NOMESCO Finland
Other healthcare associate professional
3.1
6.5
29
103
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.5
6.5
23
71
ZXD05
NOMESCO Finland
Urgent procedure
2.1
6.5
85
502
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
71.8
6.5
7
*
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
71.8
6.5
7
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.7
6.5
21
61
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
9.7
6.4
12
13
3AC01, ,
NOMESCO Finland
18.6
6.3
9
5
4464A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Wegener's granulomatosis
+∞
6.3
6
*
N085, M318,
ICD-10 Finland
+∞
6.3
6
*
J05AB01
ATC
aciclovir; systemic
2.2
6.2
63
335
N03AX16
ATC
[U] pregabalin
2.2
6.2
59
306
R04.2
ICD-10 Finland
Haemoptysis
5.8
6.1
16
29
A02BC01
ATC
omeprazole; systemic
2.1
6.1
76
438
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.3
6.1
15
25
ZXA05
NOMESCO Finland
Left side
2.1
6.1
67
369
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
7.6
6.0
13
18

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
63
64
13.16
57.85
4.7
1.2
—
—
—
0
0
39
17
27.40
54.85
1.6
1.2
—
—
—
0
0
67
81
11.24
54.34
9.6
1.8
1.34
1.45
g/l
0.32
60
71
52
51
12.87
48.47
4.1
1.2
10.36
—
iu/ml
—
9
0
53
72
9.26
38.63
6.4
1.3
16.35
6.49
iu/ml
0.97
16
13
41
44
11.11
35.55
1.5
1.4
—
—
—
0
0
75
163
6.33
35.24
6.9
3.0
91.34
68.89
e9/l
2.31
55
124
154
642
5.20
32.82
24.3
5.0
—
—
—
0
0
36
39
10.75
30.87
1.6
1.4
110.11
160.08
au/ml
—
8
12
33
35
10.83
28.65
2.1
1.1
6.06
4.41
u/ml
0.23
18
17
188
982
5.91
28.55
25.5
5.7
0.65
0.57
e9/l
4.29
183
835
34
38
10.32
28.44
1.5
1.2
—
—
—
0
0
188
988
5.85
28.16
25.5
5.7
0.04
0.04
e9/l
0.52
183
839
189
1011
5.78
27.30
25.5
5.7
1.61
1.97
e9/l
2.38
182
891
33
38
9.96
26.97
1.5
1.2
228.12
217.75
u/ml
0.04
25
24
68
170
5.25
26.76
8.4
5.6
0.84
0.75
%
0.15
40
53
95
331
4.18
24.16
7.5
3.2
0.81
0.82
mmol/l
0.21
90
319
60
149
5.09
23.58
1.8
1.4
—
—
—
0
0
134
602
3.92
23.39
16.3
4.1
7.40
7.40
ph
0.03
114
419
61
158
4.89
22.73
8.7
5.8
0.06
0.15
%
0.51
33
40
61
158
4.89
22.73
8.5
5.6
0.64
0.41
%
0.52
33
43
125
545
3.82
22.64
9.4
4.1
—
—
—
0
0
78
246
4.28
22.56
2.1
1.3
692.41
395.71
titre
1.13
29
56
74
226
4.35
22.32
3.4
1.6
—
—
—
0
0
101
386
3.87
22.20
2.6
2.1
—
—
—
0
0
177
986
4.40
21.96
30.2
7.3
1.21
1.21
mmol/l
0.03
163
872
74
229
4.28
21.89
2.8
1.6
—
—
—
0
0
38
67
6.59
21.49
1.5
1.3
—
—
—
0
0
92
338
3.86
21.29
2.8
1.8
—
—
—
0
0
61
168
4.58
20.94
24.7
8.6
—
—
—
0
0
59
159
4.64
20.81
8.7
6.2
0.13
0.05
%
0.32
30
39
141
694
3.65
20.63
12.3
3.2
40.68
142.99
e6/l
0.55
132
532
66
196
4.31
20.50
16.2
3.4
1.09
1.77
mmol/l
1.02
61
166
188
1127
4.59
20.20
29.8
9.3
4.43
4.20
e9/l
0.70
181
976
30
46
7.35
19.25
2.4
1.2
23.77
1.78
u/ml
—
13
5
22
5
48.38
18.59
2.1
2.2
—
—
—
0
0
65
204
4.04
18.57
17.6
3.5
7.38
7.38
ph
0.18
46
127
156
854
3.55
18.57
15.8
4.7
34.05
35.74
g/l
3.26
151
812
80
302
3.52
17.27
3.9
2.1
—
—
—
0
0
36
75
5.50
17.02
7.0
1.5
21.61
20.25
s
1.30
36
69
146
796
3.27
16.92
15.0
3.8
41.23
92.70
e6/l
1.03
133
557
26
17
17.06
16.64
5.7
1.1
—
—
—
0
0
46
125
4.35
15.80
9.2
3.4
7.40
7.42
ph
1.39
37
107
129
676
3.06
15.64
11.0
3.3
6.74
7.66
mmol/l
1.92
122
582
64
222
3.60
15.58
12.4
9.6
0.26
0.84
mmol/l
0.57
50
185
28
26
12.09
15.48
3.0
1.8
—
—
—
0
0
65
229
3.56
15.43
12.3
9.4
7.42
7.41
ph
0.45
35
139
118
593
3.02
15.35
3.0
1.9
134.28
226.14
u/l
1.58
113
564
123
634
3.01
15.26
10.2
3.4
137.05
63.37
mg/l
1.40
104
429
50
151
3.95
14.85
2.9
2.3
60.63
66.35
g/l
4.03
50
140
124
649
2.97
14.85
12.2
4.1
31.22
10.66
mg/mmol
1.73
101
421
25
20
13.86
14.78
1.2
1.3
—
—
—
0
0
98
458
2.98
14.34
4.4
1.6
1.92
1.12
mg/l
2.23
87
373
147
856
2.97
14.24
9.1
3.3
6.40
6.18
ph
1.68
84
480
115
599
2.83
13.57
13.1
3.1
0.23
0.38
e6/l
0.78
106
440
23
39
6.44
13.34
2.1
1.3
—
—
—
0
0
106
535
2.81
13.21
6.9
2.7
368.02
342.14
umol/l
1.53
100
467
25
48
5.72
12.80
6.0
2.7
62.80
60.66
%
0.32
25
48
23
41
6.12
12.69
12.6
2.0
74.67
58.78
%
2.61
23
41
29
65
4.96
12.53
6.5
3.5
562.13
328.42
mg/l
0.50
23
26
26
53
5.40
12.49
3.4
3.6
7.96
3.03
ratio
0.32
15
27
22
21
11.45
12.05
1.2
1.2
—
—
—
0
0
41
124
3.80
12.03
2.9
1.9
—
—
—
0
0
166
1090
2.86
11.85
10.8
3.6
0.00
0.00
estimate
-0.00
39
237
167
1104
2.85
11.69
10.9
3.6
0.00
0.00
estimate
-0.00
40
240
62
248
3.05
11.67
2.7
1.5
—
—
—
0
0
167
1116
2.79
11.23
10.9
3.6
0.00
0.00
estimate
-0.00
39
224
146
914
2.62
11.21
23.1
13.3
1.19
1.26
inr
0.83
128
758
32
85
4.21
11.19
8.7
3.6
—
—
—
0
0
118
669
2.56
11.16
4.9
2.3
—
—
—
0
0
21
40
5.67
10.81
7.5
3.1
14.86
8.85
pmol/l
1.09
21
40
118
677
2.52
10.77
5.9
3.2
2.33
2.35
mmol/l
0.43
110
622
20
20
10.83
10.75
3.2
3.0
1.22
1.30
g/24h
0.05
13
12
23
30
8.39
10.68
6.0
2.8
4.80
4.57
e9/l
0.14
23
30
189
1377
3.05
10.23
15.7
4.3
—
3.26
—
0
6
16
11
15.51
10.16
1.5
1.5
15.19
10.73
umol/l
1.20
16
11
15
9
17.70
10.01
2.8
1.3
14.67
11.00
%
—
15
9
86
439
2.53
9.92
14.5
5.8
—
—
—
0
0
64
283
2.74
9.87
18.1
6.5
104.00
104.55
mmol/l
0.39
64
283
72
338
2.64
9.87
10.3
2.9
1.52
2.66
e6/l
0.55
48
170
86
443
2.50
9.69
2.2
1.4
1.65
2.51
g/l
4.90
68
264
19
37
5.51
9.53
5.4
3.0
—
—
—
0
0
22
49
4.86
9.53
3.3
2.6
1.91
1.48
index
0.15
11
33
21
30
7.59
9.26
3.2
5.6
—
—
—
0
0
107
619
2.36
9.21
4.2
3.0
—
—
—
0
0
94
516
2.39
9.10
3.7
2.1
3.17
2.83
mg/l
0.69
86
454
17
19
9.56
8.70
2.2
1.1
—
—
—
0
0
88
481
2.34
8.50
10.1
3.5
—
0.40
—
0
5
15
14
11.37
8.42
1.5
1.2
—
—
—
0
0
15
14
11.37
8.42
1.5
1.3
—
—
—
0
0
42
161
2.97
8.35
1.9
1.3
—
—
—
0
0
13
10
13.68
7.98
1.3
1.1
—
—
—
0
0
135
898
2.21
7.93
35.4
11.1
0.01
0.00
e9/l
0.26
124
725
35
125
3.12
7.84
1.3
1.2
55.92
340.84
u/ml
0.85
27
118
18
28
6.88
7.58
5.0
2.8
—
—
—
0
0
33
118
3.10
7.37
4.3
7.7
—
—
—
0
0
17
28
6.46
6.92
1.8
1.5
—
—
—
0
0
17
28
6.46
6.92
1.8
1.5
—
—
—
0
0
17
28
6.46
6.92
1.8
1.5
—
—
—
0
0
17
28
6.46
6.92
1.8
1.5
—
—
—
0
0
41
172
2.68
6.85
4.4
1.9
0.00
0.00
estimate
—
9
42
16
26
6.53
6.59
1.6
2.3
—
—
—
0
0
96
590
2.07
6.59
7.5
2.9
—
0.00
—
0
12
13
16
8.53
6.42
6.2
3.8
—
—
—
0
0
27
93
3.16
6.40
5.1
2.0
0.00
0.00
estimate
—
10
35
98
613
2.04
6.36
21.2
6.4
—
—
—
0
0
9
5
18.64
6.31
2.7
1.2
29.89
29.20
%
—
9
5
9
5
18.64
6.31
3.2
2.2
0.62
0.61
mmol/l
—
9
5
16
29
5.85
6.11
1.2
1.2
—
—
—
0
0
136
972
1.97
5.88
5.2
2.8
—
—
estimate
—
0
0
11
12
9.56
5.85
1.9
4.3
—
—
—
0
0
92
577
1.99
5.82
2.0
1.6
17.56
20.57
nmol/l
1.19
82
487
14
23
6.41
5.79
2.6
3.2
—
—
—
0
0
9
7
13.31
5.63
2.2
4.7
1598.78
1003.57
u/ml
—
9
7
70
405
2.05
5.50
4.1
4.0
198.42
277.35
ng/l
0.24
57
308
5
0
+∞
5.22
5.4
0.0
4.81
—
mg/l
—
5
0
9
11
8.46
4.60
1.2
1.2
—
—
—
0
0
8
8
10.30
4.55
1.0
1.0
1552.88
1452.25
miu/ml
—
8
8
91
607
1.82
4.54
11.9
3.7
0.00
0.01
estimate
0.50
35
220
10
15
6.91
4.51
1.4
1.0
—
—
—
0
0
7
6
11.97
4.30
1.1
1.2
—
—
—
0
0
14
34
4.31
4.29
3.6
3.0
1.66
2.83
mmol/l
—
8
22
10
18
5.75
4.02
1.0
1.2
—
—
—
0
0
16
55
3.05
3.82
1.5
1.4
320.00
293.17
ug/g
—
9
30
7
8
8.98
3.80
1.3
1.0
—
—
—
0
0
6
5
12.27
3.78
1.0
1.0
—
—
—
0
0
19
73
2.75
3.74
3.0
2.9
—
—
—
0
0
116
864
1.69
3.74
2.5
2.1
95.01
97.54
pmol/l
0.22
72
451
8
13
6.33
3.53
1.0
1.2
—
—
—
0
0
29
141
2.21
3.50
12.4
4.0
1.22
1.22
mmol/l
0.08
29
122
9
18
5.16
3.40
1.8
1.2
—
—
—
0
0
52
320
1.81
3.25
1.7
1.7
1084.46
1189.93
nmol/l
0.43
46
253
24
112
2.28
3.19
1.2
1.1
—
—
—
0
0
8
16
5.14
3.08
1.4
1.3
—
—
—
0
0
6
8
7.66
3.07
5.7
2.5
0.50
0.63
index
—
6
8
109
828
1.60
3.07
11.1
3.6
0.00
0.02
estimate
0.50
33
193
31
164
2.03
3.03
12.9
4.0
7.29
7.36
ph
0.55
25
118
101
756
1.60
3.01
6.0
3.6
74.57
42.30
ng/l
0.66
84
515
106
808
1.58
2.90
2.7
2.1
—
—
—
0
0
8
18
4.56
2.82
4.3
1.5
-1.43
0.43
mmol/l
—
8
18
10
28
3.68
2.82
1.1
1.1
—
—
—
0
0
5
6
8.48
2.76
2.0
1.2
—
—
—
0
0
6
10
6.12
2.71
1.5
1.1
—
—
—
0
0
8
19
4.32
2.70
1.3
1.4
86.23
90.62
%
—
8
19
15
61
2.56
2.68
1.3
1.2
—
—
—
0
0
22
107
2.17
2.67
1.6
1.2
—
—
—
0
0
53
764
0.60
2.67
4.5
3.1
—
—
—
0
0
6
11
5.57
2.56
1.5
1.1
—
—
—
0
0
6
11
5.57
2.56
6.0
3.1
481.67
477.83
min
—
6
6
38
230
1.78
2.50
2.1
2.0
—
—
—
0
0
10
32
3.22
2.46
5.5
2.9
1.20
0.83
%
—
10
23
9
27
3.43
2.42
2.3
1.3
—
—
—
0
0
8
22
3.73
2.38
8.3
2.1
10.56
11.03
%
—
8
22
7
17
4.21
2.38
1.0
1.2
105.43
108.65
pmol/l
—
7
17
11
39
2.91
2.38
1.1
1.2
—
—
—
0
0
29
164
1.88
2.36
15.4
3.7
—
—
—
0
0
82
615
1.52
2.30
9.5
3.1
0.00
0.00
estimate
-0.00
33
183
5
9
5.65
2.22
7.2
5.0
54.10
48.33
%
—
5
9
14
61
2.38
2.19
1.6
1.2
—
—
—
0
0
6
14
4.37
2.16
1.2
1.1
—
—
—
0
0
16
75
2.22
2.14
1.1
1.3
260.33
240.09
miu/ml
—
6
39
8
25
3.28
2.11
1.1
1.1
—
—
—
0
0
7
20
3.58
2.07
1.1
1.2
—
—
—
0
0
11
44
2.58
2.04
1.4
1.1
4.39
3.79
mmol/l
0.69
11
44
7
21
3.40
1.98
1.4
2.2
—
—
—
0
0
8
27
3.03
1.95
5.3
2.9
35.13
32.30
pg
—
8
27
6
16
3.82
1.94
1.8
1.7
—
—
—
0
0
7
22
3.25
1.89
2.1
1.4
27.50
39.30
ng/l
—
7
22
5
13
3.91
1.72
1.2
1.2
—
—
—
0
0
53
385
1.49
1.69
1.9
1.8
145833758.38
35562766.22
pmol/l
0.33
48
329
6
19
3.21
1.67
2.2
1.4
—
—
—
0
0
30
193
1.64
1.61
2.4
2.5
41.58
30.50
u/l
0.80
24
159
6
22
2.77
1.44
1.2
1.1
277.83
279.35
mosm/kgh2o
—
6
17
64
498
1.39
1.41
1.3
1.4
2.48
1.50
u/ml
0.30
17
137
7
29
2.46
1.40
4.3
1.1
—
—
—
0
0
62
482
1.39
1.37
11.1
3.7
1.02
1.02
kg/l
0.89
55
318
75
602
1.36
1.36
1.8
1.5
—
—
—
0
0
24
154
1.62
1.32
3.4
2.4
3.11
8.20
ug/l
1.97
19
135
37
264
1.48
1.29
1.6
1.3
—
—
—
0
0
97
824
1.31
1.18
2.3
2.0
1.49
1.36
mmol/l
0.72
86
698
15
88
1.75
1.14
9.1
4.1
36.98
36.95
°c
0.29
15
88
32
229
1.46
1.11
1.6
1.4
—
—
—
0
0
7
31
2.30
1.11
3.0
2.9
3.26
6.18
umol/l
—
7
23
5
21
2.41
1.09
1.0
1.0
—
—
—
0
0
5
21
2.41
1.09
1.0
1.0
—
—
—
0
0
10
52
1.96
1.08
1.1
1.2
—
50.00
—
0
5
14
83
1.73
1.04
1.2
1.2
—
—
—
0
0
26
182
1.48
1.01
2.2
1.4
—
—
—
0
0
36
269
1.40
1.00
1.4
1.2
—
—
—
0
0
25
175
1.48
0.98
1.2
1.2
—
—
—
0
0
16
101
1.63
0.96
9.6
3.6
1.02
1.02
ratio
0.26
16
95
12
195
0.59
0.95
1.3
1.4
—
—
—
0
0
205
1957
1.42
0.91
59.6
14.9
19.76
23.82
mg/l
1.69
198
1610
6
30
2.03
0.87
1.2
1.2
—
—
—
0
0
163
1522
1.24
0.76
4.6
4.5
14.73
14.82
pmol/l
0.17
158
1383
177
1860
0.79
0.74
6.9
5.0
5.99
5.95
mmol/l
0.13
168
1718
28
360
0.75
0.71
2.4
3.3
0.74
0.75
ug/l
0.03
19
233
26
201
1.33
0.62
2.8
4.6
2.90
65.35
ug/l
0.93
20
166
27
212
1.31
0.59
1.8
1.8
—
—
—
0
0
187
1940
0.81
0.56
7.4
5.7
2.47
2.69
mmol/l
3.19
180
1810
8
58
1.39
0.42
5.1
4.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
185.66
—
0
16
0
17
0.00
0.41
0.0
19.3
—
932.12
—
0
17
188
1823
1.17
0.37
9.1
6.4
38.83
39.26
mmol/mol
0.25
182
1725
6
41
1.48
0.36
3.7
2.0
—
—
—
0
0
176
1816
0.87
0.36
6.1
4.2
1.42
1.27
mmol/l
1.99
169
1684
185
1902
0.86
0.35
6.8
4.9
1.47
1.46
mmol/l
0.05
178
1774
11
86
1.29
0.26
4.3
1.4
—
—
—
0
0
11
86
1.29
0.26
1.5
1.5
0.12
0.18
mg/l
—
5
36
5
72
0.69
0.26
3.4
1.4
338.80
326.48
mu/l
—
5
67
5
39
1.29
0.23
1.0
1.1
—
—
—
0
0
5
39
1.29
0.23
1.0
1.1
—
—
—
0
0
186
1820
1.11
0.23
5.9
5.5
1.97
1.89
mu/l
0.38
179
1677
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
8.74
—
0
10
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
3.0
—
39.90
—
0
6
11
89
1.25
0.21
4.3
1.4
—
—
—
0
0
40
366
1.11
0.20
1.3
1.3
2.85
10.44
u/ml
1.43
12
140
21
238
0.87
0.19
1.2
1.5
—
—
—
0
0
18
156
1.17
0.19
1.4
1.2
84.86
139.43
u/ml
—
5
57
7
59
1.19
0.18
12.1
1.7
—
—
—
0
0
11
91
1.22
0.18
2.8
1.4
—
—
—
0
0
11
91
1.22
0.18
4.3
1.4
—
—
—
0
0
11
91
1.22
0.18
4.3
1.4
—
—
—
0
0
8
73
1.10
0.16
5.5
1.4
—
—
—
0
0
200
2024
0.91
0.14
39.9
13.3
—
—
—
0
0
12
137
0.87
0.12
1.1
1.2
—
—
—
0
0
10
86
1.17
0.11
5.5
1.6
—
—
—
0
0
10
87
1.16
0.09
2.1
2.5
—
—
—
0
0
5
62
0.80
0.08
1.8
1.2
0.87
0.84
g/l
—
5
62
5
65
0.76
0.08
19.0
9.8
—
—
—
0
0
13
118
1.11
0.07
1.9
1.7
1148.99
932.61
mu/l
0.39
13
97
9
103
0.87
0.06
1.1
1.1
—
—
—
0
0
41
396
1.04
0.05
1.3
1.3
53.99
31.94
iu/ml
0.59
13
113
58
590
0.98
0.02
3.9
5.5
1.69
2.48
ug/l
0.75
52
528
5
55
0.91
0.00
1.6
1.7
—
—
—
0
0
5
54
0.92
-0.00
1.6
1.7
1.48
1.25
mm
—
5
41
5
57
0.87
-0.00
1.6
1.8
—
—
—
0
0
8
87
0.92
-0.00
1.1
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
34.05
—
0
6
6
59
1.02
-0.00
1.7
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.03
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
3.00
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint M13_HTROMBMICROANG and mortality.

Females

Parameter HR [95% CI] p-value
M13_HTROMBMICROANG 3.027 [2.31, 3.96] < 0.001
Birth year 0.992 [0.98, 1.0] 0.064

During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 569 females with M13_HTROMBMICROANG died.

Males

Parameter HR [95% CI] p-value
M13_HTROMBMICROANG 2.429 [1.94, 3.05] < 0.001
Birth year 0.991 [0.98, 1.0] 0.065

During the follow-up period (1.1.1998 — 31.12.2019), 137 out of 411 males with M13_HTROMBMICROANG died.

Mortality risk

Mortality risk for people of age

years, who have M13_HTROMBMICROANG.

N-year risk Females Males
1 0.267% 0.436%
5 1.504% 2.909%
10 3.987% 7.723%
15 7.418% 14.785%
20 12.635% 24.923%

Relationships between endpoints

↥

Index endpoint: M13_HTROMBMICROANG – Thrombotic microangiopathy

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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