No definition available.
Other congenital malformations of heart
DOID EFO Endpoint Browser PheWeb
Q17_OTHER_CONGEN_MALFO_HEART
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
280 |
4. Check minimum number of eventsNone |
280 |
5. Include endpointsNone |
280 |
6. Filter based on genotype QC (FinnGen only) |
241 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q2
- Name in latin
- Aliae malformationes congenitae cordis
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of heart
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly, including avohilmo
- Congenital malformations, deformations and chromosomal abnormalities
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2325 | 1187 | 1135 |
| Only index persons | 1745 | 915 | 830 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 10.16 | 13.47 | 6.64 |
| Only index persons | 16.61 | 21.73 | 10.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 241 | 142 | 99 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 24.44 | 28.38 | 18.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 261
- Matched controls
- 2608
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
65.9
144.1
82
18
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
37.7
140.8
95
39
201
Kela drug reimbursment
Chronic cardiac insufficiency
48.3
124.5
76
22
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
46.5
100.1
61
17
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
13.9
99.8
124
159
XF404
NOMESCO Finland
Ambulatory ECG
19.0
96.1
87
67
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
11.8
92.8
149
264
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
37.8
91.4
59
20
B01AA03
ATC
warfarin; systemic
16.5
89.4
88
78
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
53.8
89.0
52
12
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
33.0
79.0
53
20
FM2CE, ,
NOMESCO Finland
18.6
70.5
61
42
XF400
NOMESCO Finland
ECG with 12 standard connections
9.6
70.0
112
190
C03DA01
ATC
spironolactone; oral
12.7
68.0
77
83
C03CA01
ATC
furosemide; systemic
8.8
64.2
109
196
TPH07
NOMESCO Finland
Cathetrisation of artery
10.2
63.6
88
124
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
60.8
56
*
Q24.6
ICD-10 Finland
Congenital heart block
+∞
59.7
55
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
9.0
57.1
88
140
XF402
NOMESCO Finland
ECG with work load test
12.1
55.6
63
67
C01AA05
ATC
digoxin; systemic
25.3
53.5
39
18
ZXE20
NOMESCO Finland
More than three and less than five hours
7.9
49.8
85
150
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.1
49.5
64
81
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.9
43.5
172
647
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
248.8
42.2
42
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.3
42.2
94
214
Q24.0
ICD-10 Finland
Dextrocardia
+∞
38.5
36
*
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
38.5
36
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
38.5
36
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
8.3
37.2
55
81
207
Kela drug reimbursment
Chronic arrhythmias
9.0
36.5
50
67
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
36.3
34
*
Z2221
NOMESCO Finland
Medical doctor
4.8
35.5
134
467
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
35.2
33
*
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
33.0
31
*
XF600
NOMESCO Finland
Bloodpressure measurement
7.2
32.7
55
93
I44.2
ICD-10 Finland
Atrioventricular block, complete
55.2
32.5
38
8
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
55.2
32.5
38
8
31
HP
Congenital heart failure surgery
+∞
31.9
30
*
61
HP
Catheterization and pressure measurement of the left side of the heart
80.3
31.7
35
5
ZXD10
NOMESCO Finland
Scheduled procedure
4.3
30.7
151
626
XF622
NOMESCO Finland
Measurement of minute volume of heart
339.4
30.5
30
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
29.7
28
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
28.7
27
*
Q20.48
ICD-10 Finland
Single ventricle
+∞
27.6
26
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
7.6
27.2
42
64
Q24.58
ICD-10 Finland
Malformation of coronary vessels
+∞
26.5
25
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.0
26.5
117
440
ZXE10
NOMESCO Finland
More than one and less than three hours
3.9
25.9
130
532
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
25.4
24
*
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
25.4
24
*
62
HP
Catheterization and pressure measurement of the right side of the heart
275.1
25.1
25
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
24.3
23
*
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
91.8
23.1
25
*
C07AB07
ATC
bisoprolol; oral
3.6
22.9
118
483
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
6.4
22.6
41
74
ZXD05
NOMESCO Finland
Urgent procedure
3.6
22.5
114
461
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
22.2
21
*
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
239.0
21.9
22
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
125.5
21.9
23
*
R4110
NOMESCO Finland
Physiotherapy
3.5
21.8
115
475
WX882
NOMESCO Finland
High dependency care
5.5
21.0
45
95
I50.9
ICD-10 Finland
Heart failure, unspecified
6.5
20.9
37
65
Z98.8
ICD-10 Finland
Other specified postsurgical states
45.8
20.8
25
6
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.5
20.7
45
96
Q24.50
ICD-10 Finland
Congenital coronary artery-coronary fistula
+∞
20.0
19
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
+∞
20.0
19
*
TFP20
NOMESCO Finland
Cardiodefibrillation
9.1
19.6
25
30
WX704
NOMESCO Finland
Intubation
5.2
19.5
45
101
WX892
NOMESCO Finland
Monitored bed care
5.0
18.4
44
102
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.3
18.3
95
382
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
+∞
17.9
17
*
Q23.11
ICD-10 Finland
Bicuspid aortic valve
192.4
17.7
18
*
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
31.3
17.7
23
8
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
31.3
17.7
23
8
C09AA02
ATC
enalapril; systemic
4.4
16.8
47
123
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
16.8
16
*
Z3231
NOMESCO Finland
Registered nurse
2.9
16.1
117
564
R07.4
ICD-10 Finland
Chest pain, unspecified
3.1
15.0
80
322
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
13.0
14.9
26
22
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.3
14.9
68
249
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
14.8
78
312
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
14.7
14
*
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
14.7
14
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
14.7
14
*
G04BE03
ATC
sildenafil; oral
38.4
14.6
18
5
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
23.9
14.4
20
9
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
14.1
69
263
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
13.7
13
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
13.7
13
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
10.9
13.3
25
25
WX402
NOMESCO Finland
General anaesthesia
2.8
13.1
94
441
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
3.9
13.0
43
127
I47.2
ICD-10 Finland
Ventricular tachycardia
18.5
12.7
19
11
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
73.5
12.7
14
*
I42.0
ICD-10 Finland
Dilated cardiomyopathy
25.8
12.6
17
7
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
12.6
12
*
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
12.6
12
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
12.6
12
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
136.2
12.5
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
11.8
68
282
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
11.5
11
*
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
11.5
11
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
11.5
11
*
4260A
ICD-9 Finland
Conduction disorders, Atrioventricular block, complete
+∞
11.5
11
*
FDA00
NOMESCO Finland
Aortoplasty and aorto-pulmonary shunt for HLHS
+∞
11.5
11
*
FAE30
NOMESCO Finland
Total cavo-pulmonary connection using fenestrated patch
+∞
11.5
11
*
ZXE00
NOMESCO Finland
One hour or less
2.5
11.5
128
732
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
125.2
11.5
12
*
73
HP
Initial pacemaker installation
125.2
11.5
12
*
C07AA07
ATC
sotalol; systemic
18.1
11.3
17
10
C01BD01
ATC
amiodarone; systemic
26.4
11.3
15
6
I35.0
ICD-10 Finland
Aortic (valve) stenosis
12.7
11.0
19
16
C07AB02
ATC
metoprolol; systemic
3.2
10.8
49
177
R50.9
ICD-10 Finland
Fever, unspecified
2.6
10.6
75
345
C09AA05
ATC
ramipril; oral
3.2
10.5
47
168
I47.1
ICD-10 Finland
Supraventricular tachycardia
5.5
10.5
21
41
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
10.5
10
*
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
10.5
10
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
10.5
10
*
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
10.5
10
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
10.5
10
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
34.0
10.4
13
*
RS224, ,
NOMESCO Finland
13.9
10.3
17
13
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.1
10.1
47
172
K84
ICPC
Heart disease other
14.1
9.8
16
12
XFE00
NOMESCO Finland
Epicardial ultrasonography
15.8
9.6
15
10
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.5
9.6
36
115
FM1CD
NOMESCO Finland
Very extensive CT of heart
103.6
9.5
10
*
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
103.6
9.5
10
*
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
3.1
9.4
43
155
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
22.7
9.4
13
6
I49.5
ICD-10 Finland
Sick sinus syndrome
11.3
9.4
17
16
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
+∞
9.4
9
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
9.4
9
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
9.4
9
*
FPF00
NOMESCO Finland
Implantation of epicardial pacemaker with ventricular electrode
+∞
9.4
9
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
9.4
9
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
9.4
9
*
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
10.6
9.2
17
17
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
7.9
9.1
20
27
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
4.5
9.1
23
55
Z2446
NOMESCO Finland
Social worker
2.9
9.0
46
177
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
8.9
69
329
R04.0
ICD-10 Finland
Epistaxis
4.2
8.8
24
61
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.8
8.7
20
44
WX872
NOMESCO Finland
Intensive care
7.8
8.6
19
26
ZXA05
NOMESCO Finland
Left side
2.6
8.5
59
266
FPJ04
NOMESCO Finland
Revision of pacemaker generator with atrial and ventricular electrodes
92.9
8.5
9
*
I49.3
ICD-10 Finland
Ventricular premature depolarization
4.0
8.4
25
68
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
8.4
8
*
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
8.4
8
*
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
+∞
8.4
8
*
I44.3
ICD-10 Finland
Other and unspecified atrioventricular block
+∞
8.4
8
*
74619
ICD-8 Finland
Congenital anomalies of heart, Transposition of great vessels
+∞
8.4
8
*
Q89.30
ICD-10 Finland
Situs inversus with dextrocardia
+∞
8.4
8
*
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
8.4
8
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
8.4
8
*
WZC30
NOMESCO Finland
Teaching
2.7
8.2
48
198
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
12.2
8.2
14
12
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
12.2
8.2
14
12
I50.1
ICD-10 Finland
Left ventricular failure
9.4
8.2
16
18
AN1
HP
Coronary angiography
4.4
8.2
21
51
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
34.5
8.1
10
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
22.8
8.1
11
5
Z3226
NOMESCO Finland
Physiotherapist
2.4
8.0
70
351
K83
ICPC
Heart valve disease NOS
46.4
7.8
9
*
XF620
NOMESCO Finland
Examination of circulation with color method
46.4
7.8
9
*
I50.0
ICD-10 Finland
Congestive heart failure
7.1
7.7
18
27
81
HP
Angiography of the heart and coronary arteries
8.4
7.7
16
20
XF640, ,
NOMESCO Finland
12.4
7.7
13
11
Z94.1
ICD-10 Finland
Heart transplant status
25.9
7.6
10
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
8.0
7.5
16
21
FM1BD
NOMESCO Finland
Extensive CT of heart
82.3
7.5
8
*
FPH10
NOMESCO Finland
Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator
82.3
7.5
8
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.2
7.4
31
106
FLE00
NOMESCO Finland
Excision of subvalvular membrane of left ventricle
+∞
7.3
7
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
7.3
7
*
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
7.3
7
*
B01AB05
ATC
enoxaparin; parenteral
2.3
7.3
64
320
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
30.9
7.2
9
*
Z3229
NOMESCO Finland
Other healthcare associate professional
2.9
7.2
36
137
XX3BT
NOMESCO Finland
Other labeling with X-ray guidance
9.2
7.1
14
16
K78
ICPC
Atrial fibrillation/flutter
6.7
7.1
17
27
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.0
7.0
32
115
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.6
7.0
24
72
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.3
7.0
27
88
ZX199
NOMESCO Finland
Other rote
14.3
6.9
11
8
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
6.9
62
312
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.3
6.9
18
44
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.4
6.8
25
79
602
Kela drug reimbursment
Children's severe malnutrition
5.8
6.7
18
33
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
4.2
6.7
18
45
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
6.6
116
752
ZX120
NOMESCO Finland
Intravenous
2.9
6.5
33
126
Z13.6
ICD-10 Finland
Special screening examination for cardiovascular disorders
71.5
6.5
7
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.5
6.4
23
71
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
6.4
61
314
JDB10
NOMESCO Finland
Percutaneous gastrostomy
9.6
6.4
12
13
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.8
6.3
33
128
ZXA00
NOMESCO Finland
Right side
2.3
6.3
56
280
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
18.6
6.3
9
5
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.5
6.3
22
67
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
3.6
6.3
21
62
Q26.8
ICD-10 Finland
Other congenital malformations of great veins
+∞
6.3
6
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
6.3
6
*
3A566, ,
NOMESCO Finland
+∞
6.3
6
*
Q26.3
ICD-10 Finland
Partial anomalous pulmonary venous connection
+∞
6.3
6
*
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
+∞
6.3
6
*
FFK20
NOMESCO Finland
Atrio-pulmonary anastomosis
+∞
6.3
6
*
FDJ00
NOMESCO Finland
End to end reconstruction of aorta for coarctation
+∞
6.3
6
*
1EA01, ,
NOMESCO Finland
+∞
6.3
6
*
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
6.3
6
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
6.3
6
*
Q20.00
ICD-10 Finland
Common arterial trunk
+∞
6.3
6
*
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
+∞
6.3
6
*
7AX01, ,
NOMESCO Finland
27.4
6.3
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
6.2
72
400
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.6
6.1
20
58
K80
ICPC
Cardiac arrhythmia NOS
3.2
6.1
24
79
F83
ICD-10 Finland
Mixed specific developmental disorders
3.9
6.0
18
49
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
176
363
12.81
97.36
10.9
3.4
823.62
930.96
ng/l
0.22
170
290
44
21
24.98
59.71
4.6
3.2
76.50
114.43
%
4.33
44
21
75
107
9.42
53.01
17.5
9.6
86.67
94.32
%
1.72
75
107
109
290
5.73
41.08
9.5
3.2
2375.60
162.31
ng/l
1.32
96
183
61
100
7.65
37.54
5.3
6.1
178.20
173.06
%
0.17
61
100
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
40
42
11.06
35.04
35.6
16.3
0.35
0.26
iu/ml
0.95
21
24
139
503
4.77
35.00
3.8
3.1
—
—
—
0
0
77
180
5.64
32.85
25.4
11.3
0.07
0.33
mmol/l
0.27
69
151
59
118
6.16
29.58
31.7
11.2
1.11
1.32
%
0.58
59
118
57
115
6.06
28.25
32.8
11.4
0.58
0.68
%
1.55
57
115
87
257
4.57
27.58
19.7
10.5
106.06
104.68
mmol/l
1.71
87
257
172
906
3.63
22.14
4.4
3.3
—
—
estimate
—
0
0
109
440
3.53
21.37
6.7
3.2
1.54
1.08
mg/l
0.74
85
349
177
1060
3.08
16.30
19.0
10.7
1.20
1.22
mmol/l
4.54
170
956
147
806
2.88
15.78
9.7
6.9
37.75
37.13
g/l
0.66
140
781
83
352
2.99
14.11
26.8
14.8
24.78
24.68
mmol/l
0.13
83
352
42
116
4.12
13.93
7.1
11.8
0.67
0.56
%
1.58
42
116
164
1012
2.67
13.06
13.0
7.3
19.64
15.73
umol/l
0.91
159
963
109
552
2.67
13.05
5.0
3.1
45.89
24.09
ng/l
0.56
66
314
187
1232
2.82
13.05
18.0
6.9
6.41
6.29
mmol/l
0.35
181
1143
84
377
2.81
12.69
16.7
10.6
1.29
1.23
mmol/l
0.89
79
352
108
559
2.59
12.21
3.7
3.0
2.74
2.77
mg/l
0.05
102
503
73
314
2.84
11.87
1.9
2.0
—
—
—
0
0
59
240
2.88
10.53
2.0
1.9
—
—
—
0
0
13
5
27.20
9.90
1.2
1.4
143.38
93.00
%
—
13
5
75
361
2.51
9.53
11.0
10.1
0.81
1.22
mmol/l
0.46
64
290
21
45
4.98
9.46
1.3
1.6
—
—
—
0
0
58
249
2.71
9.28
1.9
1.8
—
—
—
0
0
18
37
5.15
8.48
1.2
1.1
1.44
1.50
u/ml
—
9
16
164
1143
2.17
8.21
4.6
3.4
82.47
78.42
ug/l
0.14
158
1094
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
12
9
13.89
7.45
1.2
1.4
113.50
120.22
%
—
12
9
62
308
2.33
7.16
18.0
9.1
1.53
0.55
mmol/l
2.46
48
225
62
322
2.21
6.39
18.9
9.0
4.94
5.00
kpa
0.39
62
308
117
772
1.93
6.24
5.1
4.2
—
—
—
0
0
75
441
1.98
5.50
3.9
3.4
1.05
0.73
e6/l
0.78
39
224
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
9
8
11.59
5.33
1.7
1.0
80.33
142.00
%
—
9
8
23
82
2.98
5.12
2.0
2.0
—
—
—
0
0
23
85
2.87
4.81
2.1
2.4
—
—
—
0
0
15
35
4.48
4.71
1.0
1.1
—
—
—
0
0
150
1137
1.75
4.63
4.5
3.7
0.00
0.00
estimate
-0.00
24
209
150
1143
1.73
4.49
4.6
3.8
0.00
7.77
estimate
0.50
24
209
18
61
3.09
4.37
7.6
12.6
—
3087.12
—
0
8
30
134
2.40
4.34
3.7
2.9
76.73
77.03
ml/min/173m2
0.01
11
58
150
1152
1.71
4.29
4.6
3.8
0.00
0.00
estimate
-0.00
21
199
7
7
10.22
4.03
14.0
9.1
1.22
1.27
mmol/l
—
7
7
246
2228
2.80
3.93
25.7
13.5
24.51
22.18
mg/l
0.60
215
1705
67
421
1.79
3.87
4.1
3.5
3.31
2.48
e6/l
0.33
31
207
17
60
2.96
3.86
1.5
1.8
—
—
—
0
0
205
1745
1.81
3.79
19.5
11.1
96.29
93.41
ml/min/173m2
0.99
186
1497
11
24
4.73
3.78
2.6
4.2
5.04
4.88
kpa
0.31
11
24
95
663
1.68
3.77
5.0
3.8
0.41
0.36
e6/l
0.11
68
453
233
2073
2.15
3.69
36.9
18.1
332.91
333.93
g/l
1.05
233
2062
15
51
3.06
3.63
4.3
5.0
—
—
—
0
0
25
112
2.36
3.61
1.8
1.6
—
—
—
0
0
10
21
4.90
3.59
1.0
1.0
90.80
95.14
%
—
10
21
173
1421
1.64
3.48
12.6
12.6
3.75
3.70
e9/l
0.11
156
1192
230
2051
2.01
3.39
36.3
17.7
13.63
13.28
%
4.30
230
2030
91
649
1.62
3.24
4.4
3.2
2.37
2.37
mmol/l
0.03
86
602
12
35
3.54
3.15
1.4
1.6
—
—
—
0
0
9
20
4.62
3.14
3.7
5.8
—
—
—
0
0
10
26
3.95
3.01
4.3
3.0
1.30
0.77
index
—
10
26
12
37
3.35
2.97
1.4
1.5
—
—
—
0
0
18
76
2.47
2.96
2.4
2.0
1.04
1.33
g/l
0.97
13
69
10
32
3.21
2.46
4.6
3.1
20.00
17.85
index
—
10
26
104
805
1.48
2.43
4.3
3.4
0.00
0.01
estimate
0.50
19
176
10
34
3.01
2.30
1.5
1.2
—
—
—
0
0
8
23
3.55
2.28
2.1
1.3
—
—
—
0
0
14
61
2.37
2.18
1.7
2.0
—
—
—
0
0
72
530
1.49
2.12
4.7
3.2
1.02
1.02
kg/l
0.04
48
350
65
469
1.51
2.10
4.8
4.1
5.09
11.29
mg/mmol
1.36
50
317
19
97
2.03
2.06
2.6
2.1
94.50
97.99
au/ml
—
6
40
11
45
2.51
1.95
1.3
2.0
—
—
—
0
0
5
11
4.61
1.95
1.6
1.1
—
—
—
0
0
99
794
1.40
1.81
2.2
2.0
1.36
1.32
mmol/l
0.13
90
709
75
575
1.43
1.77
4.2
3.9
0.00
0.01
estimate
0.50
22
194
27
164
1.72
1.76
5.6
6.7
—
—
—
0
0
117
969
1.37
1.75
3.7
3.1
72.56
72.09
nmol/l
0.06
110
898
20
111
1.87
1.74
2.4
2.1
195.33
169.45
u/ml
0.15
15
56
14
71
2.03
1.57
2.0
1.5
—
—
—
0
0
255
2473
2.32
1.45
40.5
20.7
88.82
88.70
fl
0.14
255
2454
11
54
2.08
1.34
1.2
1.5
—
—
—
0
0
255
2476
2.27
1.32
43.4
20.9
134.78
135.29
g/l
0.22
255
2456
255
2474
2.30
1.32
48.5
21.5
40.23
40.38
%
0.20
255
2452
8
34
2.39
1.30
1.5
2.3
—
—
—
0
0
12
62
1.98
1.29
2.0
1.4
—
—
—
0
0
12
62
1.98
1.29
2.0
1.4
—
—
—
0
0
5
18
2.81
1.29
2.8
3.7
2.30
3.68
nmol/l
—
5
18
5
18
2.81
1.29
1.2
1.7
—
—
—
0
0
9
44
2.08
1.28
1.7
2.0
—
—
—
0
0
8
36
2.26
1.25
1.0
1.2
—
—
—
0
0
10
49
2.08
1.23
1.7
2.3
—
—
—
0
0
5
19
2.66
1.22
2.4
2.3
1.17
1.19
mmol/l
—
5
19
5
19
2.66
1.22
4.8
2.2
10.60
9.53
mmol/l
—
5
19
5
19
2.66
1.22
2.4
2.3
107.20
105.11
mmol/l
—
5
19
12
65
1.89
1.15
1.9
1.6
—
—
—
0
0
11
58
1.93
1.13
1.9
2.2
—
—
—
0
0
21
136
1.59
1.12
2.3
1.8
—
—
—
0
0
13
213
0.59
1.05
1.4
1.7
3.49
3.49
mmol/l
—
7
148
18
115
1.61
1.02
2.5
2.0
—
—
—
0
0
23
157
1.51
1.00
3.0
2.9
—
—
—
0
0
197
1840
1.28
0.96
5.5
4.2
1.38
1.45
mmol/l
1.92
197
1745
16
101
1.62
0.95
1.5
1.5
0.95
1.19
ratio
—
8
65
16
101
1.62
0.95
1.5
1.5
1.17
1.23
ratio
—
8
65
16
101
1.62
0.95
1.5
1.5
1.36
0.96
ratio
—
8
65
172
1582
1.25
0.95
4.8
4.6
7.33
8.99
mm/h
1.96
165
1489
7
37
1.91
0.94
1.3
1.9
—
—
—
0
0
27
195
1.43
0.90
2.4
2.1
14.88
16.53
iu/l
0.18
17
152
17
250
0.66
0.89
1.1
1.1
—
—
—
0
0
10
57
1.78
0.84
1.8
2.0
—
—
—
0
0
23
164
1.44
0.83
2.6
2.3
3937.36
6162.24
u/l
—
5
63
15
98
1.56
0.80
1.5
1.5
—
—
—
0
0
8
48
1.69
0.79
1.0
1.5
—
—
—
0
0
10
59
1.72
0.76
1.0
1.3
—
—
—
0
0
5
24
2.10
0.75
1.2
1.0
77.00
76.83
%
—
5
24
5
91
0.54
0.68
1.2
1.7
—
—
—
0
0
13
86
1.54
0.67
5.1
2.8
1.02
1.02
ratio
1.70
13
79
21
154
1.39
0.67
3.0
2.3
8.55
6.91
u/l
0.25
13
102
15
103
1.48
0.66
1.3
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
5.4
—
25.29
—
0
21
8
52
1.55
0.60
2.3
2.4
140.38
132.32
g/l
—
8
40
29
361
0.78
0.59
1.3
1.3
1.09
10.11
u/ml
3.06
14
137
68
596
1.19
0.56
2.9
3.0
0.00
0.01
estimate
0.50
20
173
74
829
0.85
0.55
1.5
1.7
0.56
3.39
u/ml
3.41
19
181
17
126
1.37
0.53
1.9
1.4
—
—
—
0
0
31
253
1.25
0.51
2.0
2.0
—
—
—
0
0
10
67
1.51
0.50
1.2
1.6
—
—
—
0
0
11
77
1.45
0.46
1.5
2.5
—
—
—
0
0
13
95
1.39
0.44
1.2
1.4
—
—
—
0
0
21
261
0.79
0.44
1.5
1.9
3.21
3.47
ratio
0.52
15
202
5
31
1.62
0.43
7.8
4.6
6.70
4.65
pmol/l
—
5
31
5
33
1.52
0.41
3.2
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
2.84
—
0
6
0
16
0.00
0.41
0.0
2.4
—
66.38
—
0
16
15
115
1.32
0.39
1.5
1.6
45.77
58.89
ug/l
—
10
102
0
19
0.00
0.39
0.0
1.7
—
2.85
—
0
19
5
78
0.63
0.36
1.6
1.7
—
—
—
0
0
80
739
1.12
0.33
2.1
1.8
89.42
97.48
pmol/l
1.03
46
367
41
461
0.87
0.32
2.5
2.3
—
—
—
0
0
23
195
1.20
0.29
1.6
1.6
902.26
925.61
mu/l
0.05
17
174
5
71
0.70
0.26
1.6
1.5
53.18
52.93
ug/l
—
5
71
52
478
1.11
0.23
1.6
1.6
18.45
21.44
nmol/l
0.94
45
408
192
1873
1.09
0.22
4.2
3.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
232.64
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
11
89
1.25
0.21
1.0
1.1
—
12.87
—
0
16
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
5.6
—
23.84
—
0
14
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
7
60
1.17
0.18
1.0
1.4
—
—
—
0
0
15
129
1.17
0.17
1.1
1.4
193.52
298.65
miu/ml
—
6
67
19
169
1.13
0.15
1.6
1.6
—
—
—
0
0
11
128
0.85
0.14
2.5
1.6
—
—
—
0
0
33
306
1.09
0.13
2.5
2.1
—
—
—
0
0
10
117
0.85
0.13
1.9
1.9
—
—
—
0
0
9
109
0.82
0.13
1.3
1.4
—
—
—
0
0
47
494
0.94
0.11
2.6
2.4
—
—
—
0
0
29
271
1.08
0.10
3.8
4.0
22.67
23.77
%
0.18
15
117
5
45
1.11
0.10
1.4
1.6
0.44
33.70
u/ml
—
5
34
5
45
1.11
0.10
3.4
1.6
—
—
—
0
0
20
216
0.92
0.09
2.4
2.7
0.47
0.78
ug/l
3.61
14
123
79
811
0.96
0.08
1.9
2.0
—
—
—
0
0
8
74
1.08
0.07
1.3
1.2
—
—
—
0
0
8
76
1.05
0.07
1.3
1.2
—
—
—
0
0
14
128
1.10
0.06
2.1
1.5
0.16
0.37
mg/l
—
5
52
18
190
0.94
0.04
1.2
1.3
191.51
165.81
u/ml
—
7
71
35
340
1.03
0.03
1.5
1.5
—
—
—
0
0
16
154
1.04
0.00
1.3
1.3
—
—
—
0
0
12
121
0.99
0.00
1.2
1.3
—
—
—
0
0
39
387
1.01
0.00
1.2
1.3
11.13
28.89
iu/ml
—
8
109
181
1811
1.00
0.00
5.7
3.9
5.80
5.66
mmol/l
0.91
175
1683
144
1437
1.00
0.00
4.8
3.7
51.89
39.15
u/l
1.76
139
1389
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
196.75
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
4.25
—
0
7
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
12.21
—
0
7
0
5
0.00
0.00
0.0
1.2
—
39.20
—
0
5
0
5
0.00
0.00
0.0
1.0
—
44.34
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
7.2
—
3.48
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
63
0.95
-0.00
1.0
1.0
2.78
3.25
kpa
—
6
57
6
62
0.97
-0.00
2.0
1.8
—
—
—
0
0
6
65
0.92
-0.00
1.5
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
14.33
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
65
0.92
-0.00
1.0
1.0
6.98
7.43
kpa
—
6
59
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_HEART and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_HEART | 2.577 [1.84, 3.61] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.577 |
During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 1004 females with Q17_OTHER_CONGEN_MALFO_HEART died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_HEART | 2.584 [1.86, 3.59] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 936 males with Q17_OTHER_CONGEN_MALFO_HEART died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_HEART.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.232% | 0.548% |
| 5 | 1.526% | 2.633% |
| 10 | 3.708% | 6.778% |
| 15 | 7.36% | 13.206% |
| 20 | 13.075% | 20.453% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_HEART – Other congenital malformations of heart
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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