No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
522 |
4. Check minimum number of eventsNone |
522 |
5. Include endpointsNone |
522 |
6. Filter based on genotype QC (FinnGen only) |
461 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Conotruncal defects
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5696 | 2805 | 2877 |
| Only index persons | 3689 | 1836 | 1853 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 0.60 | 0.54 | 0.45 |
| Only index persons | 2.47 | 3.18 | 1.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 461 | 222 | 239 |
| Unadjusted period prevalence (%) | 0.09 | 0.08 | 0.11 |
| Median age at first event (years) | 6.92 | 10.69 | 3.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 504
- Matched controls
- 5040
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
19.8
265.0
290
323
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
26.8
264.2
211
132
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
33.2
263.8
187
88
201
Kela drug reimbursment
Chronic cardiac insufficiency
39.6
247.1
161
59
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
54.1
243.8
144
37
XF404
NOMESCO Finland
Ambulatory ECG
22.8
236.8
203
145
XF402
NOMESCO Finland
ECG with work load test
22.8
212.3
176
116
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
190.0
170
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
11.5
175.3
300
571
C01AA05
ATC
digoxin; systemic
37.9
168.5
108
36
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
81.4
152.9
82
12
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
149.6
136
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
25.2
145.3
108
54
B01AA03
ATC
warfarin; systemic
14.0
142.4
152
151
XF400
NOMESCO Finland
ECG with 12 standard connections
9.4
141.5
254
493
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
87.9
141.5
75
10
C03CA01
ATC
furosemide; systemic
10.6
140.4
198
289
C03DA01
ATC
spironolactone; oral
13.0
134.2
150
159
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
131.1
120
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.3
130.3
165
208
TPH07
NOMESCO Finland
Cathetrisation of artery
9.5
117.5
174
265
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
39.8
115.7
72
21
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
50.5
112.7
66
15
FM2CE, ,
NOMESCO Finland
11.8
108.1
125
137
ZXE20
NOMESCO Finland
More than three and less than five hours
8.1
103.9
180
324
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
22.0
99.8
77
41
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.1
97.8
202
434
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
20.0
95.6
77
45
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.6
94.0
347
1259
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
59.1
93.7
53
10
Z2221
NOMESCO Finland
Medical doctor
5.9
88.5
288
925
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
21.1
87.1
68
37
Q21.10
ICD-10 Finland
Persistent ostium secundum
17.5
86.2
74
49
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
26.6
83.6
59
25
ZXE30
NOMESCO Finland
More than five and less than seven hours
9.8
82.9
108
137
Z98.8
ICD-10 Finland
Other specified postsurgical states
39.5
80.6
50
14
ZXD10
NOMESCO Finland
Scheduled procedure
5.2
72.7
315
1231
31
HP
Congenital heart failure surgery
137.4
67.8
71
6
TFP20
NOMESCO Finland
Cardiodefibrillation
13.4
67.4
67
57
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
+∞
67.2
63
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
7.9
66.5
103
159
ZXE40
NOMESCO Finland
More than seven and less than nine hours
12.9
63.2
64
56
XF600
NOMESCO Finland
Bloodpressure measurement
6.2
63.0
130
269
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
61.8
58
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.5
61.2
253
925
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.4
60.2
116
224
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
59.6
56
*
WX872
NOMESCO Finland
Intensive care
13.2
59.4
59
50
62
HP
Catheterization and pressure measurement of the right side of the heart
217.9
57.3
58
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
7.4
57.2
92
147
74629
ICD-8 Finland
Congenital anomalies of heart, Tetralogy of Fallot
613.2
56.8
55
*
207
Kela drug reimbursment
Chronic arrhythmias
8.3
56.8
81
113
61
HP
Catheterization and pressure measurement of the left side of the heart
78.2
55.6
62
9
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
86.2
55.4
61
8
ZXE10
NOMESCO Finland
More than one and less than three hours
4.1
54.8
264
1059
C01BD01
ATC
amiodarone; systemic
19.2
54.7
44
25
XFE00
NOMESCO Finland
Epicardial ultrasonography
16.2
52.6
46
31
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
17.3
50.9
43
27
R4110
NOMESCO Finland
Physiotherapy
3.9
49.9
241
955
WX882
NOMESCO Finland
High dependency care
5.6
47.7
104
223
C07AA07
ATC
sotalol; systemic
18.6
46.7
38
22
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
46.6
44
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
12.5
46.2
47
41
I44.2
ICD-10 Finland
Atrioventricular block, complete
18.9
45.9
37
21
I50.9
ICD-10 Finland
Heart failure, unspecified
7.7
44.8
67
98
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
16.2
44.7
39
26
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
98.7
41.5
45
5
Q21.3
ICD-10 Finland
Tetralogy of Fallot
+∞
41.2
39
*
XF640, ,
NOMESCO Finland
17.3
40.4
34
21
I49.5
ICD-10 Finland
Sick sinus syndrome
17.3
40.4
34
21
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
40.1
38
*
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
39.1
37
*
7452A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[TETRALOGIA FALLOT]
+∞
39.1
37
*
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
39.1
37
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.5
39.0
194
762
7451A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[TRANSPOSITIO CORDIS COMPLETA]
+∞
38.0
36
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
38.0
36
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
5.8
37.8
76
150
ZXD05
NOMESCO Finland
Urgent procedure
3.3
37.1
210
888
WX892
NOMESCO Finland
Monitored bed care
4.9
36.4
90
213
Q25.0
ICD-10 Finland
Patent ductus arteriosus
11.3
35.3
38
36
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
128.9
34.1
36
*
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
+∞
33.7
32
*
74619
ICD-8 Finland
Congenital anomalies of heart, Transposition of great vessels
+∞
33.7
32
*
C07AB07
ATC
bisoprolol; oral
3.2
33.3
187
778
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
79.5
33.3
37
5
XF620
NOMESCO Finland
Examination of circulation with color method
64.4
31.5
36
6
Z3231
NOMESCO Finland
Registered nurse
3.0
31.1
238
1171
I47.1
ICD-10 Finland
Supraventricular tachycardia
6.5
30.9
53
89
XF622
NOMESCO Finland
Measurement of minute volume of heart
55.2
30.8
36
7
ZXE00
NOMESCO Finland
One hour or less
2.9
30.6
267
1407
Q20.48
ICD-10 Finland
Single ventricle
113.7
30.0
32
*
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
+∞
29.5
28
*
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
41.6
28.4
35
9
Q21.32
ICD-10 Finland
Pulmonary atresia with Fallot ventricular septal defect
+∞
28.4
27
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
+∞
28.4
27
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
37.5
27.8
35
10
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
6.3
27.2
48
83
Z3226
NOMESCO Finland
Physiotherapist
2.9
26.5
166
722
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
273.9
25.9
26
*
ZX120
NOMESCO Finland
Intravenous
4.1
25.6
79
220
I47.2
ICD-10 Finland
Ventricular tachycardia
10.9
25.6
28
27
RS224, ,
NOMESCO Finland
10.2
25.2
29
30
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
25.2
24
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
262.5
24.9
25
*
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
262.5
24.9
25
*
I50.1
ICD-10 Finland
Left ventricular failure
9.3
24.4
30
34
WX402
NOMESCO Finland
General anaesthesia
2.7
24.4
184
876
AEX
HP
Other pulmonary or pulmonary artery valve procedure
+∞
24.2
23
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
71.1
24.1
27
*
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
91.3
23.9
26
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
23.7
136
559
I50.0
ICD-10 Finland
Congestive heart failure
8.0
23.6
33
44
C09AA05
ATC
ramipril; oral
3.6
23.2
85
266
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
42.3
22.9
28
7
G04BE03
ATC
sildenafil; oral
22.0
22.9
33
16
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
22.0
21
*
Q20.00
ICD-10 Finland
Common arterial trunk
+∞
22.0
21
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
8.7
21.6
28
34
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
24.4
21.5
30
13
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
21.0
20
*
AP3
HP
Catheterization of the right and left side of the heart
218.7
20.7
21
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
26.8
20.7
28
11
AN1
HP
Coronary angiography
5.7
20.3
39
73
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
8.3
20.2
27
34
Q25.1
ICD-10 Finland
Coarctation of aorta
16.2
20.0
32
21
1EA01, ,
NOMESCO Finland
+∞
19.9
19
*
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
+∞
19.9
19
*
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
+∞
19.9
19
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
19.9
19
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
6.5
19.6
33
54
C09AA02
ATC
enalapril; systemic
3.6
19.6
71
220
FM1DM
NOMESCO Finland
Heart very extensive MRI examination with 3 Tesla magnet
+∞
18.9
18
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.7
18.8
130
582
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
197.0
18.7
19
*
TFP34
NOMESCO Finland
Electrophysiological investigation
7.5
18.4
27
38
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
18.2
115
492
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
5.6
18.0
35
66
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
23.8
17.9
25
11
TFP45
NOMESCO Finland
Ablation treatment of non-typical atrial flutter
+∞
17.8
17
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
186.3
17.6
18
*
Q87.14
ICD-10 Finland
Noonan's syndrome
43.7
17.4
21
5
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
5.2
17.1
36
73
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.2
16.9
73
252
Q22.2
ICD-10 Finland
Congenital pulmonary valve insufficiency
+∞
16.8
16
*
FDB20
NOMESCO Finland
Arterial switch operation for other congenital heart defect
+∞
16.8
16
*
I48.4
ICD-10 Finland
Atypical atrial flutter
93.2
16.7
18
*
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
12.8
16.0
28
23
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
+∞
15.7
15
*
AP2
HP
Catheterization of the right side of the heart
+∞
15.7
15
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
20.0
15.7
23
12
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
15.6
134
659
AF1
HP
Surgery of congenital heart defect
164.9
15.6
16
*
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
13.6
15.3
26
20
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.3
15.3
41
102
FM1BD
NOMESCO Finland
Extensive CT of heart
46.5
15.2
18
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
32.8
14.9
19
6
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
3.0
14.8
74
277
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.4
14.7
38
92
AD1
HP
TVP
+∞
14.7
14
*
5253
FHL
Cardiac lung machine
82.6
14.6
16
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
82.6
14.6
16
*
FBA96
NOMESCO Finland
Other suture or repair of pulmonary artery
154.3
14.5
15
*
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
28.1
14.4
19
7
R04.0
ICD-10 Finland
Epistaxis
3.9
14.3
44
121
XQ903
NOMESCO Finland
Production of other scan or drawing
23.1
14.3
20
9
B01AB05
ATC
enoxaparin; parenteral
2.5
14.2
109
507
Z2446
NOMESCO Finland
Social worker
2.6
14.1
94
409
Q21.0
ICD-10 Finland
Ventricular septal defect
31.0
14.0
18
6
C07AB02
ATC
metoprolol; systemic
2.9
13.8
69
258
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.1
13.6
176
1017
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
13.6
13
*
Q21.33
ICD-10 Finland
Fallots pentalogi
+∞
13.6
13
*
Q24.0
ICD-10 Finland
Dextrocardia
143.7
13.5
14
*
74709
ICD-8 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
143.7
13.5
14
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
143.7
13.5
14
*
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
18.9
13.5
20
11
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
13.4
127
647
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
5.5
13.4
26
49
WX002
NOMESCO Finland
Sedation and analgesia
2.6
13.4
85
361
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
12.6
13.2
23
19
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
23.3
13.0
18
8
FPH10
NOMESCO Finland
Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator
51.4
12.9
15
*
ZX199
NOMESCO Finland
Other rote
11.4
12.6
23
21
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
+∞
12.5
12
*
Q22.41
ICD-10 Finland
Tricuspid atresia
+∞
12.5
12
*
FK1AC
NOMESCO Finland
Right cardioangiography
+∞
12.5
12
*
74734
ICD-8 Finland
Other congenital anomalies of circulatory system, Stenosis, hypoplasia sive aplasia arteriae pulmonalis
+∞
12.5
12
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
25.0
12.5
17
7
Q21.19
ICD-10 Finland
Atrial septal defect NOS
25.0
12.5
17
7
90492, ,
NOMESCO Finland
133.2
12.5
13
*
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
133.2
12.5
13
*
K84
ICPC
Heart disease other
10.0
12.4
24
25
Q26.1
ICD-10 Finland
Persistent left superior vena cava
38.6
12.3
15
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
38.6
12.3
15
*
WX704
NOMESCO Finland
Intubation
3.2
12.3
50
166
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
12.1
108
535
I44.1
ICD-10 Finland
Atrioventricular block, second degree
21.9
12.1
17
8
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
12.0
234
1550
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.8
11.8
37
103
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
3.6
11.6
39
114
Z94.1
ICD-10 Finland
Heart transplant status
14.0
11.5
19
14
5208
FHL
Total correction of Fallot's tetralogy
+∞
11.5
11
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
11.5
11
*
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
+∞
11.5
11
*
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
11.5
11
*
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
+∞
11.5
11
*
74689
ICD-8 Finland
Congenital anomalies of heart, Aliae definitae
+∞
11.5
11
*
TFP35
NOMESCO Finland
Electroanatomical mapping
12.2
11.4
20
17
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.7
11.4
37
106
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
35.9
11.3
14
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.5
11.2
40
122
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
11.5
11.1
20
18
B01AF02
ATC
apixaban; oral
3.6
11.1
37
108
7AX01, ,
NOMESCO Finland
15.9
10.9
17
11
Q25.40
ICD-10 Finland
Aortic hypoplasia
22.0
10.7
15
7
RK260, ,
NOMESCO Finland
22.0
10.7
15
7
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
112.3
10.5
11
*
1CX08, ,
NOMESCO Finland
112.3
10.5
11
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
10.4
10
*
602
Kela drug reimbursment
Children's severe malnutrition
3.8
10.4
32
88
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
33.3
10.4
13
*
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
23.9
10.3
14
6
B34.9
ICD-10 Finland
Viral infection, unspecified
3.0
10.2
48
173
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
10.2
57
226
K78
ICPC
Atrial fibrillation/flutter
5.2
10.1
21
42
FN1AD
NOMESCO Finland
CT of coronary arteries
11.6
10.1
18
16
GD1AD
NOMESCO Finland
Thorax CT examination
3.6
10.1
33
95
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.4
10.1
36
110
J96.1
ICD-10 Finland
Chronic respiratory failure
12.5
9.9
17
14
L04AD02
ATC
tacrolimus; systemic
4.7
9.9
23
51
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
26.6
9.9
13
5
K83
ICPC
Heart valve disease NOS
26.6
9.9
13
5
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
56.1
9.7
11
*
XX3BW, ,
NOMESCO Finland
56.1
9.7
11
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
56.1
9.7
11
*
F83
ICD-10 Finland
Mixed specific developmental disorders
3.3
9.7
37
118
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
8.6
9.6
20
24
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
9.4
9.6
19
21
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
9.5
64
278
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
9.5
53
210
Q20.9
ICD-10 Finland
Congenital malformation of cardiac chambers and connections, unspecified
101.9
9.4
10
*
FJD96
NOMESCO Finland
Other operation on right ventricle outlet for congenital or acquired obstruction
101.9
9.4
10
*
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
30.7
9.4
12
*
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
30.7
9.4
12
*
Q21.21
ICD-10 Finland
Atrioventricular duct
30.7
9.4
12
*
FJF96
NOMESCO Finland
Other prosthetic replacement of pulmonary valve
+∞
9.4
9
*
7452B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[DOUBLE OUTLET RIGHT VENTRICLE AND PULMONAL STENOSIS]
+∞
9.4
9
*
7451X
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[MUU TRANSPOSITIO]
+∞
9.4
9
*
AH3
HP
Treatment of arrhythmias, eg atrial fibrillation, in conjunction with other cardiac surgery
+∞
9.4
9
*
7460B
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITUM CUM ATRESIA]
+∞
9.4
9
*
7453B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Common ventricle[COMMON VENTRICLE]
+∞
9.4
9
*
5239
FHL
Other measure in this category
+∞
9.4
9
*
Z31.5
ICD-10 Finland
Genetic counselling
2.5
9.4
62
267
205
Kela drug reimbursment
Chronic hypertension
2.6
9.3
58
243
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.4
9.2
33
101
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
5.2
9.2
19
38
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.9
9.0
43
157
XG460
NOMESCO Finland
Short time oxymetry
8.8
8.9
18
21
Q23.11
ICD-10 Finland
Bicuspid aortic valve
6.8
8.7
21
32
K99
ICPC
Cardiovascular disease other
14.4
8.7
14
10
3A019, ,
NOMESCO Finland
14.4
8.7
14
10
ZX108
NOMESCO Finland
Inhalation
8.4
8.6
18
22
127
Kela drug reimbursment
Transplant complication
3.9
8.6
25
66
UGC02
NOMESCO Finland
Rigid bronchoscopy
9.2
8.6
17
19
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
91.5
8.4
9
*
XFP02, ,
NOMESCO Finland
91.5
8.4
9
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
8.4
96
520
ZF61V, ,
NOMESCO Finland
+∞
8.4
8
*
Q25.8
ICD-10 Finland
Other congenital malformations of great arteries
+∞
8.4
8
*
Q22.40
ICD-10 Finland
Congenital tricuspid stenosis
+∞
8.4
8
*
FBE20
NOMESCO Finland
Reconstruction of pulmonary artery using tube graft
+∞
8.4
8
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
10.3
8.1
15
15
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.3
8.1
30
94
R50.9
ICD-10 Finland
Fever, unspecified
1.9
8.1
118
695
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
22.4
8.0
11
5
3A077, ,
NOMESCO Finland
22.4
8.0
11
5
J01CA04
ATC
amoxicillin; systemic
2.5
8.0
459
4060
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.4
8.0
20
47
RD210, ,
NOMESCO Finland
2.9
8.0
38
138
R62.0
ICD-10 Finland
Delayed milestone
2.9
8.0
39
144
C02EA02, ,
ATC
8.0
7.9
17
22
ZXA00
NOMESCO Finland
Right side
2.0
7.8
93
511
R06.0
ICD-10 Finland
Dyspnoea
1.9
7.7
109
633
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
45.7
7.7
9
*
FQA10
NOMESCO Finland
Orthotopic transplantation of heart with bicaval anastomosis
45.7
7.7
9
*
FFE02
NOMESCO Finland
Percutaneous transluminal atrial septostomy
45.7
7.7
9
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
45.7
7.7
9
*
FPJ04
NOMESCO Finland
Revision of pacemaker generator with atrial and ventricular electrodes
45.7
7.7
9
*
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.9
7.7
36
130
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
8.2
7.6
16
20
WX870
NOMESCO Finland
Other postsurgical intensive care
18.7
7.6
11
6
I97.0
ICD-10 Finland
Postcardiotomy syndrome
18.7
7.6
11
6
1AB02, ,
NOMESCO Finland
12.1
7.6
13
11
GD1LA
NOMESCO Finland
GD
12.1
7.6
13
11
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
25.4
7.6
10
*
FM1AD
NOMESCO Finland
CT of heart
25.4
7.6
10
*
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
2.8
7.5
37
137
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
81.2
7.4
8
*
FPF00
NOMESCO Finland
Implantation of epicardial pacemaker with ventricular electrode
81.2
7.4
8
*
74
HP
Initial installation of the atrial pacemaker
81.2
7.4
8
*
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
4.3
7.3
19
46
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
7.3
68
339
7450A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Common truncus[TRUNCUS ARTERIOSUS COMMUNIS]
+∞
7.3
7
*
FHE00
NOMESCO Finland
Transatrial repair of tetralogy of Fallot
+∞
7.3
7
*
7452C
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[PULMONARY ATRESIA AND VENTRICULAR SEPTAL DEFECT]
+∞
7.3
7
*
Q22.6
ICD-10 Finland
Hypoplastic right heart syndrome
+∞
7.3
7
*
Q20.41
ICD-10 Finland
Double inlet right ventricle
+∞
7.3
7
*
Q25.70
ICD-10 Finland
Aneurysm, congenital of pulmonary artery
+∞
7.3
7
*
Q20.4
ICD-10 Finland
Double inlet ventricle
+∞
7.3
7
*
7468X
ICD-9 Finland
Other congenital anomalies of heart, Other specified anomalies of heart[MUU SYDÄMEN EPÄMUODOSTUMA]
+∞
7.3
7
*
FHB96
NOMESCO Finland
Other closure of congenital ventricular septal defect
+∞
7.3
7
*
74669
ICD-8 Finland
Congenital anomalies of heart, Aliae maleformationes valvulae pulmonaris sive ventriculi dextri
+∞
7.3
7
*
FBJ00
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery
+∞
7.3
7
*
5269
FHL
Other measure in this category
+∞
7.3
7
*
51
HP
Other heart surgery
+∞
7.3
7
*
5504
FHL
Subclavian pulmonary anastomosis (Blalock)
+∞
7.3
7
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.8
7.3
36
134
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
7.5
7.2
16
22
73
HP
Initial pacemaker installation
30.5
7.2
9
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
6.7
7.2
17
26
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
20.4
7.2
10
5
FPK00
NOMESCO Finland
Implantation of electrocardiograph with loop recorder
20.4
7.2
10
5
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
7.1
7.0
16
23
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
14.0
6.9
11
8
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
9.5
6.8
13
14
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
6.8
41
169
FBE96
NOMESCO Finland
Other expansion or reconstruction of pulmonary artery
40.6
6.8
8
*
C08DB01
ATC
diltiazem; oral
7.3
6.7
15
21
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
22.9
6.7
9
*
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
22.9
6.7
9
*
Q25.3
ICD-10 Finland
Stenosis of aorta
22.9
6.7
9
*
Q21.20
ICD-10 Finland
Atrial septal defect of primum type
22.9
6.7
9
*
L04AA06
ATC
mycophenolic acid; systemic
3.5
6.6
22
64
J45.1
ICD-10 Finland
Nonallergic asthma
2.2
6.6
57
276
M01AH05
ATC
etoricoxib; oral
0.6
6.5
111
1680
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
4.0
6.5
18
46
FB1BC
NOMESCO Finland
Extensive angiography of arteria pulmonalis
70.7
6.4
7
*
5401
FHL
Pacemaker installation, transvenous electrode
70.7
6.4
7
*
FMC96
NOMESCO Finland
Other operation on aortic valve for insufficiency
70.7
6.4
7
*
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
14.5
6.4
10
7
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
6.7
6.4
15
23
I35.0
ICD-10 Finland
Aortic (valve) stenosis
5.3
6.4
18
35
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
5.3
6.4
18
35
I49.3
ICD-10 Finland
Ventricular premature depolarization
2.9
6.4
29
103
B01AB04
ATC
dalteparin; parenteral
3.5
6.4
21
61
81
HP
Angiography of the heart and coronary arteries
6.1
6.3
16
27
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.4
6.3
22
66
AP1
HP
Catheterization of the left side of the heart
11.2
6.3
11
10
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.3
100
601
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
18.3
6.3
9
5
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
18.3
6.3
9
5
324, ,
NOMESCO Finland
18.3
6.3
9
5
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
2.7
6.3
33
127
7461A
ICD-9 Finland
Other congenital anomalies of heart, Tricuspid atresia and stenosis, congenital[VITIUM VALVULAE TRICUSPIDALIS CONGENITUM CUM ATRESI]
+∞
6.3
6
*
I37.8
ICD-10 Finland
Other pulmonary valve disorders
+∞
6.3
6
*
5207
FHL
VSD closure
+∞
6.3
6
*
FGE10
NOMESCO Finland
Replacement of tricuspid valve using biological prosthesis
+∞
6.3
6
*
Q25.5
ICD-10 Finland
Atresia of pulmonary artery
+∞
6.3
6
*
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
6.3
6
*
5233
FHL
Right ventricular bypass surgery (Fontan et al.)
+∞
6.3
6
*
7473A
ICD-9 Finland
Other congenital anomalies of circulatory system, Anomalies of pulmonary artery
+∞
6.3
6
*
FBL96
NOMESCO Finland
Other connection to pulmonary artery from aorta
+∞
6.3
6
*
Q22.3
ICD-10 Finland
Other congenital malformations of pulmonary valve
+∞
6.3
6
*
Q21.4
ICD-10 Finland
Aortopulmonary septal defect
+∞
6.3
6
*
7468B
ICD-9 Finland
Other congenital anomalies of heart, Other specified anomalies of heart[STENOSIS PULMONALIS INFUNDIBULARIS]
+∞
6.3
6
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.2
6.2
52
248
7470A
ICD-9 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
27.0
6.2
8
*
RS221, ,
NOMESCO Finland
3.5
6.2
21
62
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.5
6.2
37
152
C10AA03
ATC
pravastatin; oral
3.3
6.1
22
68
WW200
NOMESCO Finland
Immunization
3.5
6.1
20
58
C09DX04
ATC
valsartan and sacubitril; oral
10.2
6.1
11
11
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
6.1
6.0
15
25
TK800
NOMESCO Finland
Hemodialysis
5.7
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
242
188
23.84
273.04
6.0
4.4
164.35
183.56
ng/l
0.22
227
167
382
635
21.72
265.98
9.3
5.2
850.52
897.60
ng/l
0.13
369
526
227
620
5.84
83.22
5.8
6.7
32.17
30.19
s
4.91
227
615
219
618
5.50
76.35
6.9
3.8
2420.85
757.67
ng/l
2.10
194
378
312
1245
4.95
69.13
30.7
8.4
1.55
1.17
inr
10.04
265
1029
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
81
92
10.30
67.11
13.7
21.7
0.30
0.36
iu/ml
0.97
52
51
253
978
4.19
55.53
3.6
3.0
—
—
—
0
0
67
84
9.05
51.10
3.6
6.3
81.93
99.23
%
3.61
67
84
99
191
6.21
51.03
1.9
2.5
25.59
8.64
ug/l
4.02
91
169
260
1107
3.79
47.92
10.3
7.7
71.27
88.46
%
22.07
260
1094
123
321
4.75
44.65
24.0
13.0
0.69
0.27
mmol/l
0.56
115
271
184
647
3.90
44.60
13.6
10.7
0.81
0.81
mmol/l
0.04
178
625
67
100
7.57
43.97
1.4
1.5
—
—
—
0
0
35
20
18.73
43.23
2.4
6.2
6.05
6.05
kpa
0.00
35
20
35
20
18.73
43.23
2.4
6.2
4.92
4.80
kpa
0.29
35
20
148
479
3.96
39.92
18.1
11.4
105.82
104.89
mmol/l
1.66
148
479
309
1714
3.07
32.93
4.3
3.3
—
—
estimate
—
0
0
189
825
3.07
30.59
4.1
4.0
1.52
1.46
mg/l
0.07
145
603
30
34
9.32
24.41
1.5
1.8
156.33
127.09
%
1.29
30
34
196
967
2.68
24.16
4.9
3.1
70.24
28.46
ng/l
0.92
131
515
298
1817
2.57
23.35
11.3
8.0
21.38
18.57
umol/l
0.79
287
1719
349
2311
2.66
22.71
16.2
7.5
6.27
6.29
mmol/l
0.09
338
2166
31
14
23.50
21.96
2.2
2.2
98.26
97.43
g/l
0.08
31
14
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
31
44
7.44
21.00
1.6
1.8
136.58
121.32
%
0.45
31
44
205
1098
2.46
20.60
3.5
3.4
3.20
2.47
mg/l
1.78
190
973
69
213
3.59
19.10
7.2
11.8
0.65
0.60
%
0.70
69
213
110
456
2.81
18.47
2.9
1.9
—
—
—
0
0
50
126
4.30
18.36
7.5
16.8
72.10
67.92
%
0.95
50
126
108
446
2.81
18.25
3.1
2.0
—
—
—
0
0
127
575
2.62
17.89
3.0
2.0
—
—
—
0
0
155
776
2.44
17.60
9.1
10.7
1.58
1.12
mmol/l
1.12
141
638
482
4018
5.57
17.30
35.4
15.0
139.35
139.57
mmol/l
1.46
482
3934
282
1842
2.21
16.71
25.1
12.5
1.20
1.22
mmol/l
11.06
274
1751
48
130
3.98
15.98
2.6
2.5
0.92
1.29
g/l
2.46
40
119
293
1998
2.11
14.87
20.2
12.0
1.20
1.22
mmol/l
5.48
276
1814
234
1476
2.09
14.54
8.9
7.8
36.18
37.57
g/l
2.74
227
1416
68
246
3.04
14.46
7.5
12.3
125.60
130.61
g/l
1.00
68
241
132
686
2.25
13.28
15.4
9.6
2.25
0.78
mmol/l
8.72
114
501
19
15
13.11
11.22
1.6
1.6
4770.17
3013.56
e6/l
—
12
9
18
13
14.31
11.04
1.6
1.7
100279.36
19368.14
e6/l
—
11
7
50
178
3.01
10.89
2.5
2.2
—
—
—
0
0
310
2305
1.90
10.73
13.3
12.3
0.00
0.00
e9/l
1.00
263
1787
299
2214
1.86
10.31
4.5
3.7
86.65
75.99
ug/l
0.76
288
2120
153
915
1.97
10.28
3.6
2.5
443.47
335.96
u/l
0.45
148
888
28
72
4.06
9.99
1.5
1.4
—
—
—
0
0
47
172
2.91
9.74
2.6
2.0
—
—
—
0
0
384
3153
1.92
8.77
22.6
10.2
97.38
96.51
ml/min/173m2
0.27
340
2659
19
25
7.85
8.72
1.3
1.1
62.50
88.40
%
—
6
5
35
117
3.14
8.48
2.1
1.9
—
—
—
0
0
100
552
2.01
8.27
4.7
6.1
8.95
7.85
umol/l
0.40
94
461
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
18
24
7.73
8.22
1.3
1.1
58.60
62.60
%
—
5
5
29
88
3.44
8.19
1.2
1.1
—
—
—
0
0
337
2688
1.77
8.10
12.6
12.3
3.80
3.72
e9/l
0.28
307
2250
31
99
3.27
8.09
1.9
1.9
—
—
—
0
0
20
32
6.46
8.09
1.3
1.1
79.80
90.18
%
0.65
15
17
29
89
3.40
8.06
1.4
1.2
1.54
3.23
u/ml
0.44
13
39
29
90
3.36
7.92
1.4
1.2
6.13
3.95
u/ml
0.54
15
43
48
199
2.56
7.85
2.4
1.6
—
—
—
0
0
49
214
2.43
7.19
3.8
3.2
65.35
76.54
ml/min/173m2
0.48
17
84
18
33
5.62
6.67
1.6
1.2
67.77
92.94
%
1.57
13
18
33
124
2.78
6.55
2.2
2.0
—
—
—
0
0
29
103
2.93
6.37
1.7
1.4
—
—
—
0
0
334
2747
1.64
6.29
11.9
7.3
94.02
100.50
u/l
1.11
326
2610
28
100
2.91
6.10
2.6
4.4
—
—
—
0
0
12
14
8.75
6.08
1.6
1.7
—
—
—
0
0
21
63
3.43
6.06
2.1
1.4
—
—
—
0
0
45
205
2.31
6.02
2.5
2.2
124.48
105.06
au/ml
0.58
21
84
35
145
2.52
5.76
15.2
12.3
294.17
398.18
iu/ml
—
6
22
467
4270
2.28
5.69
26.7
13.2
24.87
22.62
mg/l
0.89
412
3236
17
46
3.79
5.69
1.9
4.9
1.24
0.72
index
1.30
17
46
49
242
2.14
5.41
1.6
1.8
—
—
—
0
0
34
145
2.44
5.28
1.9
1.5
—
—
—
0
0
13
22
6.04
5.25
1.5
1.6
1.08
0.78
iu/ml
—
8
11
497
4761
4.16
5.17
38.3
20.1
88.70
88.11
fl
1.92
497
4725
497
4767
4.07
5.02
40.0
20.4
135.60
136.44
g/l
0.51
497
4728
497
4763
4.13
5.00
44.4
21.1
40.40
40.60
%
0.37
497
4723
30
126
2.47
4.82
2.3
3.6
11.14
6.62
index
0.27
21
76
42
208
2.11
4.62
2.6
2.1
—
—
—
0
0
50
269
1.95
4.41
5.3
3.9
4.68
4.88
pmol/l
0.37
45
248
34
159
2.22
4.32
7.4
7.3
24.74
24.56
mmol/l
0.15
34
152
23
90
2.63
4.28
1.7
1.6
—
—
—
0
0
122
879
1.51
3.67
4.3
3.2
5.71
7.22
e6/l
0.48
110
785
12
32
3.82
3.41
2.1
3.4
31.42
32.69
pg
0.35
12
32
7
10
7.08
3.37
1.7
1.2
11.00
15.10
u/l
—
7
10
138
1040
1.45
3.29
3.6
2.9
52.28
60.81
u/l
1.01
133
977
10
25
4.06
3.10
1.5
1.2
—
—
—
0
0
18
74
2.49
3.08
2.2
1.9
—
—
—
0
0
452
4234
1.65
3.01
15.7
10.9
27.06
28.36
u/l
0.76
445
4134
173
1378
1.39
2.98
4.8
4.2
22.55
85.23
e6/l
0.69
136
1015
25
121
2.12
2.98
1.4
1.6
—
—
—
0
0
7
13
5.44
2.87
1.3
1.3
396.37
294.43
u/l
—
7
13
21
97
2.22
2.81
2.2
1.7
—
—
—
0
0
5
6
8.40
2.75
1.2
1.3
13.60
13.83
u/l
—
5
6
42
252
1.73
2.68
2.4
2.0
210.39
179.50
u/ml
0.33
28
122
16
67
2.43
2.66
2.1
1.6
—
—
—
0
0
10
30
3.38
2.61
1.4
1.2
—
—
—
0
0
12
44
2.77
2.56
2.0
2.6
—
—
—
0
0
155
1241
1.36
2.53
4.6
4.0
0.52
0.26
e6/l
0.79
119
874
9
26
3.51
2.49
1.7
1.7
—
—
—
0
0
5
154
0.32
2.32
1.0
4.1
405.60
348.26
e6/l
—
5
111
130
1610
0.74
2.27
1.6
1.8
0.82
2.72
u/ml
3.03
37
332
354
3827
0.75
2.26
4.1
3.8
—
—
—
0
0
29
485
0.57
2.26
3.0
2.4
10.96
12.59
nmol/l
0.52
29
454
18
87
2.11
2.19
2.9
2.1
—
—
—
0
0
8
25
3.23
2.10
5.9
3.2
—
—
—
0
0
41
263
1.61
2.08
7.4
5.6
—
—
—
0
0
10
38
2.66
2.01
2.5
1.5
—
—
—
0
0
58
406
1.48
2.01
2.2
2.5
32.40
31.85
u/l
0.04
47
332
9
203
0.43
2.00
1.6
1.8
39.11
36.76
nmol/l
—
9
196
41
266
1.59
2.00
3.7
2.7
—
—
—
0
0
25
142
1.80
1.96
1.2
1.2
—
—
—
0
0
8
27
2.99
1.94
9.1
9.1
—
—
—
0
0
9
33
2.76
1.94
1.2
1.7
—
—
—
0
0
9
33
2.76
1.94
1.2
1.7
—
—
—
0
0
9
33
2.76
1.94
1.2
1.7
—
—
—
0
0
6
156
0.38
1.92
1.8
1.8
143.50
234.09
pmol/l
—
6
150
39
253
1.59
1.91
3.3
3.3
0.20
0.15
e6/l
0.30
39
242
23
129
1.82
1.89
1.5
1.5
—
—
—
0
0
23
129
1.82
1.89
1.5
1.5
—
—
—
0
0
138
1135
1.30
1.81
3.6
3.3
2.36
2.38
mmol/l
0.99
132
1059
101
795
1.34
1.81
3.2
3.8
2.91
1.94
e6/l
0.40
56
400
278
2490
1.26
1.81
5.3
4.1
14.00
511.83
e6/l
—
7
30
79
1021
0.73
1.79
1.9
2.2
—
—
—
0
0
0
49
0.00
1.69
0.0
1.3
—
—
—
0
0
30
456
0.64
1.62
1.1
1.1
—
—
—
0
0
47
331
1.46
1.61
1.5
1.6
1065.79
1177.49
nmol/l
0.42
38
254
7
160
0.43
1.56
1.0
3.9
430.86
436.50
mg/l
—
7
153
87
1087
0.76
1.55
2.0
2.4
—
—
—
0
0
8
33
2.45
1.54
1.4
1.8
—
965650.00
—
0
5
12
58
2.10
1.50
2.6
1.2
—
—
—
0
0
7
152
0.45
1.46
1.0
3.9
3.76
3.42
mmol/l
—
7
144
13
66
2.00
1.44
8.3
6.3
6.65
6.26
pmol/l
0.10
13
66
9
39
2.33
1.43
4.2
3.3
753.89
935.74
u/ml
—
9
39
20
324
0.60
1.43
1.2
1.2
6.22
6.49
u/ml
0.03
14
242
7
29
2.43
1.39
3.0
4.7
208.86
199.78
ug/l
—
7
29
20
319
0.61
1.35
1.1
1.2
1.72
1.18
u/ml
0.15
13
219
67
520
1.33
1.34
1.5
1.6
461.98
39400876.56
pmol/l
0.76
60
467
13
69
1.91
1.29
1.4
1.9
—
—
—
0
0
38
270
1.44
1.28
1.7
1.6
—
—
—
0
0
6
25
2.42
1.24
1.3
1.1
—
—
—
0
0
20
311
0.63
1.23
4.4
3.7
30.46
31.17
%
0.11
13
221
7
141
0.49
1.22
1.1
1.3
—
—
—
0
0
8
37
2.18
1.22
1.1
1.2
—
—
—
0
0
5
19
2.65
1.22
1.0
1.7
—
—
—
0
0
28
403
0.68
1.21
1.5
1.6
3.34
3.48
mmol/l
0.25
20
269
5
20
2.51
1.15
1.0
1.6
—
—
—
0
0
21
135
1.58
1.13
1.1
1.1
—
—
—
0
0
31
218
1.45
1.12
1.4
1.4
—
—
—
0
0
24
350
0.67
1.11
1.2
1.3
17.68
2.47
u/ml
1.44
18
247
16
96
1.69
1.11
1.5
1.8
—
—
—
0
0
7
32
2.20
1.08
1.7
1.6
—
—
—
0
0
7
32
2.20
1.08
6.4
7.4
—
—
—
0
0
20
129
1.57
1.07
2.2
2.1
2.43
4.02
iu/l
—
7
52
10
52
1.94
1.07
1.1
4.0
43.41
22.01
mg/l
—
10
47
10
52
1.94
1.07
1.1
4.0
51.55
34.73
mg/l
—
10
47
21
138
1.54
1.04
1.1
1.1
—
—
—
0
0
5
110
0.45
1.01
1.8
1.3
—
—
—
0
0
23
156
1.50
1.00
1.6
2.0
66.48
20.29
ng/l
0.62
23
156
332
3129
1.18
0.98
5.4
4.9
36.53
37.40
mmol/mol
1.24
316
2986
0
29
0.00
0.98
0.0
1.0
—
—
—
0
0
16
100
1.62
0.98
1.8
2.0
—
—
—
0
0
20
134
1.51
0.93
1.1
3.0
—
—
—
0
0
6
29
2.08
0.89
6.2
3.0
1.21
1.20
mmol/l
—
6
29
6
29
2.08
0.89
6.2
3.0
107.17
105.86
mmol/l
—
6
29
18
263
0.67
0.87
1.5
1.5
—
—
—
0
0
13
204
0.63
0.87
1.1
1.1
0.02
1.31
u/ml
—
6
100
96
826
1.20
0.85
3.5
3.5
0.77
0.59
e6/l
0.33
52
428
26
350
0.73
0.81
3.0
2.1
6.57
6.33
u/l
0.04
18
238
15
223
0.66
0.80
1.1
1.1
9.86
7.03
u/ml
—
10
143
23
315
0.72
0.80
1.1
1.2
4.95
2.22
u/ml
0.47
16
226
41
515
0.78
0.80
1.7
1.8
3.71
3.57
ratio
0.30
33
383
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
3.1
—
143.17
—
0
24
5
98
0.51
0.78
1.2
1.2
—
62.79
—
0
7
0
26
0.00
0.78
0.0
1.1
—
32.73
—
0
26
16
233
0.68
0.78
1.0
1.4
—
—
—
0
0
16
233
0.68
0.78
1.3
1.8
—
—
—
0
0
0
28
0.00
0.76
0.0
2.2
—
—
—
0
0
5
24
2.09
0.74
2.0
1.3
79.40
70.33
umol/l
—
5
24
333
3174
1.14
0.73
4.2
3.6
1.28
1.23
mmol/l
0.58
316
2999
6
106
0.56
0.73
1.2
1.5
—
—
—
0
0
10
158
0.63
0.71
2.1
1.8
—
—
—
0
0
58
484
1.22
0.71
1.6
2.2
2.41
2.43
mmol/l
0.45
50
426
304
2884
1.14
0.71
7.1
4.6
7.51
8.39
mm/h
1.00
291
2711
9
143
0.62
0.70
1.4
1.6
79.81
55.64
ug/l
—
9
143
14
93
1.52
0.70
1.6
1.8
—
—
—
0
0
11
69
1.61
0.69
1.0
1.0
160.27
163.54
g/l
0.24
11
69
23
171
1.36
0.66
2.0
1.4
—
—
—
0
0
28
356
0.77
0.62
2.2
2.4
0.49
0.71
ug/l
1.86
15
174
15
210
0.71
0.62
1.1
1.1
6.63
10.24
u/ml
—
10
123
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
354
3411
1.13
0.58
4.8
4.2
4.30
4.57
mmol/l
5.61
342
3249
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
114
1257
0.88
0.56
1.8
1.8
88.61
95.53
pmol/l
1.05
59
639
23
179
1.30
0.52
1.0
1.1
1.37
1.47
g/l
1.48
23
179
86
956
0.88
0.49
4.3
3.2
1.02
1.02
kg/l
0.40
53
619
23
181
1.28
0.49
1.0
1.1
0.85
0.89
g/l
0.30
23
181
33
397
0.82
0.48
1.5
1.6
1138.57
950.37
mu/l
0.35
25
339
112
1022
1.12
0.48
4.4
3.5
0.05
0.01
estimate
0.42
40
377
64
564
1.15
0.46
1.5
1.6
—
—
—
0
0
7
51
1.38
0.44
1.4
1.3
—
—
—
0
0
13
95
1.38
0.44
2.5
4.5
13.67
17.98
u/ml
0.13
13
95
335
3243
1.10
0.43
5.0
4.1
15.23
14.57
pmol/l
5.06
316
3027
14
184
0.75
0.42
1.4
1.7
—
—
—
0
0
8
57
1.41
0.42
1.1
4.8
—
—
—
0
0
8
57
1.41
0.42
1.1
4.8
—
—
—
0
0
8
58
1.39
0.41
1.4
1.2
84.63
76.47
%
—
8
58
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
2.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
71.40
—
0
15
0
16
0.00
0.41
0.0
2.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
82.26
228.10
iu/ml
—
5
34
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
5
35
1.43
0.39
10.0
5.0
6.60
8.14
%
—
5
35
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
348
3385
1.09
0.38
4.7
4.1
1.32
1.40
mmol/l
3.46
334
3213
219
2091
1.08
0.38
4.2
3.7
29.93
8.05
estimate
0.32
45
389
5
37
1.35
0.37
1.2
1.1
—
—
—
0
0
11
146
0.75
0.36
1.0
1.0
21.18
19.29
mmol/l
2.22
11
146
48
542
0.87
0.36
1.7
2.1
—
—
—
0
0
350
3411
1.09
0.35
5.1
4.4
2.62
2.76
mmol/l
2.43
335
3237
34
293
1.17
0.34
1.7
1.2
—
—
—
0
0
6
46
1.31
0.33
1.7
1.1
—
—
—
0
0
334
3254
1.08
0.32
3.9
3.6
5.67
5.65
mmol/l
0.10
320
3018
6
47
1.28
0.32
4.5
5.9
—
—
—
0
0
55
606
0.90
0.29
3.2
3.7
1.02
1.44
ug/l
2.41
50
554
7
56
1.25
0.29
1.0
1.2
—
—
—
0
0
26
223
1.17
0.29
1.2
1.4
154.02
261.61
miu/ml
—
7
113
41
459
0.88
0.28
3.0
3.5
27.54
22.42
%
0.77
14
161
11
138
0.79
0.26
1.6
2.2
1.58
0.60
nmol/l
0.76
11
124
9
76
1.19
0.24
1.3
1.6
—
—
—
0
0
84
786
1.08
0.24
4.9
4.3
11.68
29.90
mg/mmol
0.41
64
536
31
349
0.88
0.24
1.8
2.6
12855.40
4604.11
u/l
—
10
136
6
84
0.71
0.24
1.0
1.3
52.33
187.71
pmol/l
—
6
78
5
38
1.32
0.23
1.4
1.2
58.40
107.95
pmol/l
—
5
38
215
2082
1.06
0.23
4.2
3.6
0.00
0.00
estimate
-0.00
44
397
5
39
1.28
0.23
2.6
2.2
17.00
40.62
mg/l
—
5
29
7
95
0.73
0.22
2.6
5.6
382.00
397.80
umol/l
—
7
88
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
51.01
—
0
7
0
12
0.00
0.21
0.0
1.0
—
543.43
—
0
7
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
70
660
1.07
0.18
1.3
1.3
17.29
21.29
iu/ml
0.33
19
172
5
68
0.73
0.17
1.8
2.2
0.21
0.12
nmol/l
—
5
55
217
2118
1.04
0.16
4.2
3.7
0.00
0.00
estimate
-0.00
40
371
6
79
0.76
0.15
4.3
5.7
2.94
2.02
ug/l
—
6
79
143
1474
0.96
0.14
4.2
3.2
0.00
0.01
estimate
0.69
37
338
13
148
0.88
0.12
1.1
1.1
—
1.83
—
0
14
149
1527
0.97
0.11
2.0
1.7
1.91
1.86
g/l
0.22
106
858
61
637
0.95
0.11
1.7
2.2
—
—
—
0
0
5
45
1.11
0.10
1.2
1.4
0.93
1.44
promille
—
5
38
19
207
0.91
0.09
1.6
1.5
1.09
1.13
ratio
—
10
127
19
207
0.91
0.09
1.6
1.5
1.07
1.26
ratio
—
10
127
19
207
0.91
0.09
1.6
1.5
0.91
0.94
ratio
—
10
127
5
48
1.04
0.09
1.2
1.2
—
—
—
0
0
5
61
0.82
0.08
1.0
1.1
—
—
—
0
0
11
122
0.90
0.07
1.1
1.4
11.08
4.25
ug/l
0.32
11
111
24
254
0.94
0.06
1.3
1.3
—
—
—
0
0
11
121
0.91
0.06
1.3
1.2
—
—
—
0
0
127
1249
1.02
0.06
4.2
4.3
6.78
8.64
mmol/l
4.58
121
1141
40
385
1.04
0.06
1.3
1.3
73.52
165.75
u/ml
1.28
14
130
376
3741
1.02
0.05
5.8
4.8
2.09
1.88
mu/l
2.54
359
3546
269
2710
0.98
0.04
4.4
4.3
51.84
37.22
u/l
2.72
261
2620
80
784
1.02
0.04
1.6
1.5
18.19
20.30
nmol/l
0.82
71
688
19
201
0.94
0.04
1.6
1.5
—
—
—
0
0
13
121
1.08
0.03
1.4
1.5
211.57
315.29
ug/g
—
7
67
60
612
0.98
0.03
1.3
1.3
14.46
6.80
u/ml
0.26
21
224
148
1466
1.01
0.03
2.0
2.0
1.38
1.36
mmol/l
0.07
140
1305
15
142
1.06
0.02
5.2
3.6
12.33
20.76
mu/l
1.32
15
137
109
1100
0.99
0.02
3.9
2.9
0.00
0.02
estimate
0.88
38
327
183
1821
1.01
0.01
4.1
3.5
72.38
71.00
nmol/l
0.28
170
1710
22
223
0.99
0.00
1.5
1.5
67.15
58.47
ug/l
0.25
17
190
27
273
0.99
0.00
1.6
1.8
—
—
—
0
0
13
129
1.01
0.00
1.1
2.0
—
—
—
0
0
170
1701
1.00
0.00
1.7
2.0
—
—
—
0
0
8
81
0.99
0.00
1.1
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
98
0.92
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
346.29
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
-0.00
4.7
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
16.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
57
0.88
-0.00
1.4
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.30
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
259.20
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONOTR_DEFEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONOTR_DEFEC | 5.183 [3.58, 7.5] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.185 |
During the follow-up period (1.1.1998 — 31.12.2019), 107 out of 1995 females with Q17_CONOTR_DEFEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONOTR_DEFEC | 5.139 [3.95, 6.69] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 145 out of 1886 males with Q17_CONOTR_DEFEC died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONOTR_DEFEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.538% | 0.792% |
| 5 | 2.78% | 5.754% |
| 10 | 7.43% | 14.799% |
| 15 | 14.02% | 25.698% |
| 20 | 23.042% | 39.601% |
Relationships between endpoints
↥Index endpoint: Q17_CONOTR_DEFEC – Conotruncal defects
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data