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Cushing syndrome

DOID EFO Endpoint Browser PheWeb

E4_CUSHING

hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E24
  • Hospital discharge: ICD-9 — 2550|2593
  • Hospital discharge: ICD-8 — 2580
  • Cause of death: ICD-10 — E24
  • Cause of death: ICD-9 — 2550|2593
  • Cause of death: ICD-8 — 2580

2 out of 7 registries used, show all original rules.

487

4. Check minimum number of events

None

487

5. Include endpoints

None

487

6. Filter based on genotype QC (FinnGen only)

424

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
E20-E35
Name in latin
Syndroma Cushing

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2517 1702 780
Only index persons 1932 1354 578
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.04 0.05 0.02
Median age at first event (years)
Whole population 52.43 51.81 53.66
Only index persons 48.38 47.55 50.32

-FinnGen-

Key figures

All Female Male
Number of individuals 424 300 124
Unadjusted period prevalence (%) 0.09 0.11 0.06
Median age at first event (years) 52.35 49.32 59.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
438
Matched controls
4380
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB09
ATC
hydrocortisone; systemic
120.2
307.7
183
26
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
+∞
171.4
153
*
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
36.8
140.8
91
31
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
+∞
127.5
116
*
E24.8
ICD-10 Finland
Other Cushing syndrome
+∞
124.0
113
*
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
41.6
94.4
58
16
H02AA02
ATC
fludrocortisone; oral
54.7
92.1
53
11
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
16.0
91.3
84
64
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
221.9
73.6
74
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
136.1
66.0
69
6
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
136.0
56.4
59
5
C03DA01
ATC
spironolactone; oral
5.8
54.3
121
269
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
160.0
54.2
56
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
52.1
49
*
E24.2
ICD-10 Finland
Drug-induced Cushing syndrome
+∞
51.0
48
*
V04CD01
ATC
metyrapone; oral
+∞
47.8
45
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
6.2
43.5
85
165
E89.6
ICD-10 Finland
Postprocedural adrenocortical(-medullary) hypofunction
+∞
40.2
38
*
E24.3
ICD-10 Finland
Ectopic ACTH syndrome
+∞
37.0
35
*
E87.6
ICD-10 Finland
Hypokalaemia
7.4
34.8
54
82
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
347.8
32.3
32
*
A10AE04
ATC
insulin glargine; parenteral
4.5
29.7
82
212
25800
ICD-8 Finland
Polyglandular dysfunction and other diseases of endocrine glands, Cushing's syndrome
+∞
29.5
28
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
29.5
28
*
C03CA01
ATC
furosemide; systemic
3.2
29.2
170
725
103
Kela drug reimbursment
Diabetes, insulin-treated
3.1
26.9
163
706
A10AB05
ATC
insulin aspart; parenteral
4.7
25.8
66
160
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
25.8
114
408
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
24.5
207
1062
BCA30
NOMESCO Finland
Unilateral adrenalectomy
+∞
24.2
23
*
H03AA01
ATC
levothyroxine sodium; systemic
2.8
22.8
158
725
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.1
22.7
123
493
2550A
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SDR CUSHING E HYPERPLASIA GLANDULAE SUPRARENALI]
+∞
22.1
21
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
21.9
90
305
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.8
21.8
147
663
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
21.5
154
716
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
21.4
253
1502
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.2
20.6
101
380
C08CA01
ATC
amlodipine; oral
2.6
20.6
202
1092
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.6
20.3
40
77
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.8
20.0
136
612
BCA41
NOMESCO Finland
Endoscopic bilateral adrenalectomy
+∞
19.9
19
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
19.9
19
*
205
Kela drug reimbursment
Chronic hypertension
2.7
19.5
134
606
JN4BD
NOMESCO Finland
Extensive body CT
3.5
19.3
77
255
A10BA02
ATC
metformin; oral
2.6
19.1
155
760
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
19.1
131
591
E23.03
ICD-10 Finland
Lack of ACTH
+∞
18.9
18
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
18.9
18
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
18.9
18
*
2550X
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING NUD]
+∞
18.9
18
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.5
18.8
74
243
TPH07
NOMESCO Finland
Cathetrisation of artery
3.5
18.6
73
239
C74.0
ICD-10 Finland
Malignant neoplasm: Cortex of adrenal gland
+∞
17.8
17
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
17.3
204
1176
A10AC01
ATC
insulin (human); parenteral
3.7
17.1
59
177
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
16.9
94
377
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
16.8
195
1112
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.9
16.8
54
154
2550B
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING E HYPERFUNCTIO GLAN SUPRARENALI]
+∞
16.8
16
*
AA1AD
NOMESCO Finland
CT of head and brain
2.4
16.7
156
809
BC1AD
NOMESCO Finland
CT of adrenal glands
12.9
16.6
29
24
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.6
16.1
40
94
E24
ICD-10 Finland
Cushing syndrome
+∞
15.7
15
*
SPAT1262
SPAT
Handing over of treatment supplies
2.8
15.6
94
393
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.4
15.5
62
205
T90
ICPC
Diabetes non-insulin dependent
2.5
15.2
127
622
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
6.6
15.2
25
40
R53
ICD-10 Finland
Malaise and fatigue
2.4
15.1
148
777
JN3AD
NOMESCO Finland
Abdominal CT examination
2.9
15.1
81
317
C07AB07
ATC
bisoprolol; oral
2.2
15.1
237
1514
R03BB04
ATC
tiotropium bromide; inhalant
3.3
14.9
61
204
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.2
14.8
41
105
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
+∞
14.7
14
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
+∞
14.7
14
*
L01XX23
ATC
mitotane; oral
+∞
14.7
14
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
14.7
14
*
ZXC86
NOMESCO Finland
Use of endoscopic device
37.4
14.5
18
5
WX892
NOMESCO Finland
Monitored bed care
3.6
14.4
50
150
N02AA05
ATC
oxycodone; systemic
2.6
14.3
101
455
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
14.3
152
824
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.1
14.1
64
228
B01AB05
ATC
enoxaparin; parenteral
2.2
13.9
164
927
E26.0
ICD-10 Finland
Primary hyperaldosteronism
77.6
13.7
15
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
13.6
13
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
5.5
13.6
27
52
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.1
13.5
29
60
C08CA13
ATC
lercanidipine; oral
2.7
13.3
84
358
BC1CD
NOMESCO Finland
Very extensive CT of adrenal glands
41.4
13.2
16
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.7
13.2
79
327
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.8
13.2
72
284
R60.0
ICD-10 Finland
Localized oedema
2.7
12.9
77
318
J01MA12
ATC
levofloxacin; systemic
2.5
12.8
98
458
R4110
NOMESCO Finland
Physiotherapy
2.2
12.6
150
845
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
12.6
12
*
E24.4
ICD-10 Finland
Alcohol-induced pseudo-Cushing syndrome
+∞
12.6
12
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
+∞
12.6
12
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
4.6
12.4
30
69
C02AC05
ATC
moxonidine; oral
4.6
12.4
30
69
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
38.7
12.3
15
*
L28
ICPC
Limited function/disability (L)
2.4
12.2
102
494
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.6
12.1
41
121
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.8
12.0
38
107
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
11.9
60
226
A03FA01
ATC
metoclopramide; systemic, rectal
2.2
11.7
129
701
A46
ICD-10 Finland
Erysipelas
2.6
11.6
76
328
AA4WT
NOMESCO Finland
Selective blood sample from sinus petrosus inferior
+∞
11.5
11
*
2533
FHL
Unilateral removal of additional egg
+∞
11.5
11
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
123.1
11.5
12
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
11.4
79
350
N91.1
ICD-10 Finland
Secondary amenorrhoea
13.2
11.2
19
15
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.2
11.2
123
667
N03AX16
ATC
[U] pregabalin
2.2
11.2
123
667
A10BJ06
ATC
semaglutide; parenteral
3.6
11.1
37
108
N04BC06
ATC
cabergoline; oral
44.5
11.0
13
*
130
Kela drug reimbursment
Malignant tumour
3.0
10.7
50
180
B01AB04
ATC
dalteparin; parenteral
3.8
10.7
33
91
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.7
10.7
63
258
I10
ICD-10 Finland
Essential (primary) hypertension
2.0
10.7
273
1991
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.8
10.6
58
228
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
14.7
10.6
17
12
Z3226
NOMESCO Finland
Physiotherapist
2.2
10.5
101
517
UJF32
NOMESCO Finland
Coloscopy
2.1
10.5
126
705
E27.2
ICD-10 Finland
Addisonian crisis
+∞
10.5
10
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
10.5
10
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.8
10.4
32
88
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
10.4
73
325
A02BC02
ATC
pantoprazole; systemic
2.1
10.3
315
2430
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
3.6
10.2
34
99
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
41.1
10.0
12
*
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
41.1
10.0
12
*
E21.0
ICD-10 Finland
Primary hyperparathyroidism
41.1
10.0
12
*
E66.01
ICD-10 Finland
Obesity due to excess calories
2.6
9.8
62
262
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
4.4
9.8
25
60
E66.8
ICD-10 Finland
Other obesity
3.2
9.7
41
139
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
9.7
181
1175
TKC20
NOMESCO Finland
Catheterisation of bladder
3.2
9.7
40
134
N02AX02
ATC
tramadol; systemic, rectal
1.9
9.6
202
1364
WZC30
NOMESCO Finland
Teaching
2.2
9.6
93
477
ZXD05
NOMESCO Finland
Urgent procedure
2.0
9.6
150
919
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
9.4
121
690
2550C
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING E HYPERSECRETIO HYPOFYSEOS]
+∞
9.4
9
*
E23.05
ICD-10 Finland
Lack of TSH
+∞
9.4
9
*
H01AC01
ATC
somatropin; parenteral
+∞
9.4
9
*
A28
ICPC
Limited function/disability NOS
2.2
9.3
86
431
OAB93, ,
SPAT
3.0
9.3
43
154
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
9.2
81
399
J01FF01
ATC
clindamycin; systemic
2.0
9.1
135
808
ZX120
NOMESCO Finland
Intravenous
2.7
9.1
53
215
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
4.2
9.1
24
59
A12BA01
ATC
potassium chloride; oral
4.0
9.1
26
68
A10AB04
ATC
insulin lispro; parenteral
3.9
9.0
27
73
WX402
NOMESCO Finland
General anaesthesia
2.0
8.9
115
655
B01AB10
ATC
tinzaparin; parenteral
2.4
8.9
65
294
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.2
8.8
80
399
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
8.7
66
304
JN4AD
NOMESCO Finland
Body CT examination
2.4
8.7
64
291
WX002
NOMESCO Finland
Sedation and analgesia
2.1
8.6
95
510
Z3231
NOMESCO Finland
Registered nurse
1.9
8.6
134
814
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
8.6
112
640
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.1
8.6
36
122
A10BJ02
ATC
liraglutide; parenteral
4.3
8.6
22
53
E0000UV, ,
ATC
1.8
8.5
202
1403
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.9
8.5
25
67
M04AA01
ATC
allopurinol; systemic
2.5
8.5
58
255
301
Kela drug reimbursment
Growth hormone
+∞
8.4
8
*
C74.9
ICD-10 Finland
Malignant neoplasm: Adrenal gland, unspecified
+∞
8.4
8
*
E24.1
ICD-10 Finland
Nelson syndrome
+∞
8.4
8
*
WX882
NOMESCO Finland
High dependency care
7.3
8.3
19
27
R06.0
ICD-10 Finland
Dyspnoea
1.9
8.3
130
790
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.9
8.3
40
147
N05CF01
ATC
zopiclone; oral
1.9
8.2
153
982
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.1
8.2
34
114
J46
ICD-10 Finland
Status asthmaticus
4.5
8.2
20
46
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.4
8.2
30
93
ZXE00
NOMESCO Finland
One hour or less
1.8
8.2
182
1235
A10BH01
ATC
sitagliptin; oral
2.6
8.1
50
209
I15.9
ICD-10 Finland
Secondary hypertension, unspecified
22.5
8.0
11
5
E66.00
ICD-10 Finland
Metabolic syndrome
3.0
8.0
36
127
WX110
NOMESCO Finland
Infiltration anesthesia
1.9
8.0
326
2643
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.7
8.0
25
70
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.3
8.0
30
95
OAB50, ,
SPAT
2.7
7.9
43
168
R4190
NOMESCO Finland
Nutritional therapy
3.4
7.9
29
90
A07AA02
ATC
nystatin; oral
3.0
7.9
35
122
C10AA01
ATC
simvastatin; oral
1.8
7.9
168
1120
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.5
7.9
28
85
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.5
7.9
27
80
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
7.9
144
918
G47.3
ICD-10 Finland
Sleep apnoea
1.9
7.8
113
667
H02AB07
ATC
prednisone; oral
2.2
7.8
70
346
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
6.1
7.8
20
34
I15.2
ICD-10 Finland
Hypertension secondary to endocrine disorders
45.8
7.7
9
*
M05BX04
ATC
denosumab; parenteral
3.0
7.7
35
124
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.7
7.7
18
40
C08CA02
ATC
felodipine; oral
2.6
7.7
45
183
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.5
7.7
52
227
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
7.7
62
293
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.7
7.7
24
67
JN4CD
NOMESCO Finland
Very extensive body CT
3.9
7.6
22
58
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.8
7.6
39
148
R50.9
ICD-10 Finland
Fever, unspecified
2.1
7.6
76
392
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
7.5
31
104
A08
ICPC
Swelling
2.8
7.5
37
138
A02BA02
ATC
ranitidine; systemic
2.0
7.4
89
491
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
81.4
7.4
8
*
318
Kela drug reimbursment
Teriparatide
+∞
7.3
7
*
C25.4
ICD-10 Finland
Malignant neoplasm: Endocrine pancreas
+∞
7.3
7
*
H05AA02
ATC
teriparatide; parenteral
+∞
7.3
7
*
8370/3-C74.0
ICD-O-3
Adrenal cortical carcinoma of cortex of adrenal gland
+∞
7.3
7
*
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
7.3
7
*
R03DA04
ATC
theophylline; systemic, rectal
3.3
7.2
27
85
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
7.2
51
227
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.4
7.2
26
80
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
6.8
7.2
17
26
XF600
NOMESCO Finland
Bloodpressure measurement
2.9
7.1
34
124
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.0
7.1
93
530
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
7.1
170
1168
C03AA03
ATC
hydrochlorothiazide; oral
2.6
7.0
43
179
S10
ICPC
Boil/carbuncle
2.8
7.0
36
137
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
6.0
7.0
18
31
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.1
6.9
28
93
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.3
6.9
54
252
Z2221
NOMESCO Finland
Medical doctor
1.8
6.9
132
849
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
40.7
6.8
8
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
6.8
102
608
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.8
6.7
20
54
A02BC03
ATC
lansoprazole; oral
1.8
6.7
132
854
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
6.1
6.7
17
29
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
6.6
81
449
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.4
6.6
48
216
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
6.6
89
512
C09DA01
ATC
losartan and diuretics; oral
2.3
6.5
52
244
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
5.5
6.5
18
34
P25
ICPC
Phase of life problem adult
3.3
6.5
24
75
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.4
6.5
46
205
A10AE05
ATC
insulin detemir; parenteral
3.0
6.5
29
102
R11
ICD-10 Finland
Nausea and vomiting
2.3
6.5
50
232
E66.9
ICD-10 Finland
Obesity, unspecified
3.2
6.4
25
81
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
4.2
6.4
17
42
T82
ICPC
Obesity
3.1
6.4
27
92
C09AA05
ATC
ramipril; oral
1.8
6.4
105
643
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.2
6.3
53
254
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
6.3
50
234
E26.9
ICD-10 Finland
Hyperaldosteronism, unspecified
+∞
6.3
6
*
E27.8
ICD-10 Finland
Other specified disorders of adrenal gland
+∞
6.3
6
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
6.3
6
*
A01AB09
ATC
miconazole; local oral
2.4
6.2
44
196
N05CD07
ATC
temazepam; oral
2.2
6.2
53
257
Z2446
NOMESCO Finland
Social worker
2.5
6.1
37
153
L01AX03
ATC
temozolomide; systemic
12.8
6.1
10
8
SPAT1139
SPAT
Nutrition survey
3.7
6.1
19
53
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.5
6.1
39
166
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.6
6.1
20
58
NF1AA
NOMESCO Finland
Hip X-ray examination
2.4
6.0
42
186
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.1
6.0
62
323

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
150
13
174.96
304.30
3.3
1.2
966.44
52.15
nmol/24h
2.25
150
13
149
18
124.94
291.34
4.3
1.3
11.31
1.42
nmol/l
2.80
143
13
269
391
16.24
202.12
9.4
1.8
375.89
378.53
nmol/l
0.04
262
369
74
43
20.50
92.37
1.3
1.2
—
—
nmol/l
—
0
0
81
58
16.91
91.05
1.4
1.2
0.31
—
nmol/l
—
7
0
76
58
15.64
82.25
1.5
1.2
253.57
326.75
pmol/l
0.66
63
53
71
50
16.75
80.24
1.4
1.2
0.71
0.17
nmol/l
0.53
45
34
62
88
8.04
42.66
2.6
1.3
11.61
11.15
u/l
0.07
52
69
328
1895
3.91
35.71
11.6
6.3
1.21
1.21
mmol/l
0.56
288
1633
299
1661
3.52
33.91
7.5
4.6
34.37
36.00
g/l
4.83
286
1565
238
1178
3.23
32.27
5.8
3.5
7.40
7.40
ph
1.24
202
799
299
1714
3.35
31.08
10.1
5.6
1.21
1.21
mmol/l
0.04
290
1573
135
489
3.55
30.42
8.7
7.0
103.47
104.04
mmol/l
0.54
135
489
301
1794
3.17
28.02
4.0
2.4
75.98
77.50
nmol/l
0.42
287
1607
86
244
4.14
27.47
3.0
3.4
4.23
4.51
pmol/l
1.43
81
215
34
40
9.13
26.99
1.7
1.1
280.50
272.90
mosm/kgh2o
0.52
26
30
110
407
3.27
23.35
10.6
7.8
7.43
7.42
ph
1.43
57
234
109
404
3.26
23.04
10.5
7.7
1.22
0.93
mmol/l
0.26
93
339
155
708
2.84
22.55
3.6
2.7
520.25
524.82
mosm/kgh2o
0.08
134
615
97
348
3.30
21.52
1.5
1.4
—
—
—
0
0
226
1301
2.52
20.00
8.5
6.0
—
—
—
0
0
324
2213
2.78
19.94
9.1
4.6
6.94
6.57
mmol/l
2.27
315
2093
286
1846
2.58
19.65
8.8
6.1
2.11
2.80
%
8.33
273
1719
285
1840
2.57
19.51
8.8
6.2
0.57
0.71
%
4.12
272
1714
37
69
5.76
19.36
1.6
1.4
63.15
62.82
mmol/l
0.01
27
62
128
567
2.78
19.34
3.1
2.2
2.34
2.34
g/l
0.02
118
527
121
523
2.81
19.14
3.1
2.2
20.88
23.21
%
1.21
114
493
85
304
3.23
18.80
11.6
8.4
—
—
—
0
0
284
1853
2.51
18.65
8.9
6.2
8.33
8.73
%
1.68
271
1733
82
289
3.26
18.57
7.0
6.2
9.80
9.05
mmol/l
0.43
82
277
302
2030
2.57
18.55
8.3
6.1
0.04
0.04
e9/l
0.49
270
1739
35
65
5.77
18.38
3.1
1.4
0.27
0.45
nmol/l
1.04
25
52
91
345
3.07
18.19
3.7
3.5
7.38
7.39
ph
1.03
49
201
183
991
2.45
18.04
6.4
4.0
—
—
—
0
0
304
2064
2.55
18.04
8.5
6.2
1.87
1.95
e9/l
0.57
281
1818
300
2025
2.53
18.02
8.4
6.1
0.63
0.57
e9/l
5.00
268
1738
83
300
3.18
17.99
4.7
3.0
1.23
1.23
mmol/l
0.11
78
253
285
1889
2.46
17.66
9.0
6.2
24.33
28.07
%
7.04
274
1786
130
613
2.59
17.09
3.1
2.2
11.53
13.69
umol/l
2.95
121
573
86
333
2.97
16.47
4.2
3.5
2.78
1.91
mmol/l
0.96
72
283
304
2110
2.44
16.44
8.7
6.4
0.15
0.19
e9/l
4.56
275
1839
278
1863
2.35
16.19
8.7
6.0
61.46
57.15
%
7.37
270
1767
192
1111
2.30
15.77
3.5
3.2
1554.97
1035.75
ng/l
0.86
173
936
71
255
3.13
15.45
3.6
3.0
101.73
69.18
ng/l
1.79
64
225
204
1226
2.24
15.13
3.8
2.5
55.23
64.44
u/l
0.94
189
1129
173
980
2.26
14.73
3.0
2.1
2.99
2.88
mg/l
0.28
156
843
67
241
3.10
14.51
2.3
1.3
21.96
24.88
iu/l
0.32
59
203
99
447
2.57
13.95
2.2
1.7
—
—
—
0
0
255
1720
2.15
13.65
20.7
10.4
1.21
1.17
inr
0.65
220
1403
309
2252
2.26
13.53
12.4
9.9
5.06
3.97
e9/l
10.84
274
1967
208
1306
2.13
13.34
3.9
3.2
6.68
7.53
mmol/l
2.04
179
1096
31
69
4.76
13.28
4.3
1.8
—
—
—
0
0
29
61
5.02
13.26
3.7
2.0
10.33
6.32
pmol/l
1.08
29
61
288
2056
2.17
13.06
9.5
6.5
9.00
10.87
umol/l
5.49
280
1961
177
1061
2.12
12.65
4.4
2.9
0.37
0.48
e6/l
0.42
140
753
149
837
2.18
12.58
3.5
2.5
6.81
6.79
e6/l
0.00
132
759
90
411
2.50
12.27
3.2
2.8
1.94
1.81
%
0.58
84
372
64
256
2.76
11.36
2.1
2.4
—
—
—
0
0
250
1749
2.00
11.26
17.7
10.8
0.00
0.00
e9/l
0.28
211
1430
193
1235
2.01
11.22
4.8
3.0
49.87
108.52
e6/l
0.45
154
924
194
1245
2.00
11.17
4.8
3.9
12.73
8.02
mg/mmol
0.54
134
739
106
542
2.26
11.11
2.6
1.9
—
—
—
0
0
153
914
2.04
10.68
2.2
1.7
0.88
1.24
mg/l
1.78
123
708
189
1217
1.97
10.65
4.1
3.3
45.73
46.00
mg/l
0.01
140
751
59
234
2.76
10.63
4.3
3.4
7.43
7.42
ph
0.46
50
192
184
1176
1.97
10.58
4.4
3.0
—
—
—
0
0
45
154
3.14
10.54
1.8
2.0
2.00
1.43
g/l
1.99
38
137
206
1370
1.95
10.52
4.6
3.3
2.35
2.35
mmol/l
0.14
194
1239
33
93
3.76
10.41
3.2
3.2
1.27
1.88
index
0.31
15
52
27
66
4.29
10.31
3.0
2.0
3.39
3.26
mmol/l
0.05
19
40
58
232
2.73
10.27
2.2
2.7
186.08
180.15
ng/l
0.05
53
211
29
77
3.96
9.94
1.3
1.7
—
—
—
0
0
75
346
2.41
9.89
4.1
4.8
0.00
0.28
%
1.34
29
78
193
1276
1.92
9.86
3.4
2.3
—
—
—
0
0
37
117
3.36
9.84
1.5
1.4
213.09
312.10
ug/g
1.76
24
65
52
201
2.80
9.82
1.4
1.2
—
—
—
0
0
360
2959
2.22
9.40
13.6
8.0
84.84
77.54
u/l
1.55
354
2798
235
1694
1.84
8.83
2.3
2.1
92.31
98.11
pmol/l
1.16
129
853
208
1446
1.83
8.79
5.6
3.7
56.02
57.34
e6/l
0.02
163
981
72
345
2.30
8.67
4.0
4.5
0.04
0.20
%
1.86
28
90
72
346
2.29
8.61
3.8
4.2
0.92
0.67
%
0.37
30
95
75
367
2.26
8.59
4.0
4.3
1.27
1.12
%
0.17
31
112
40
145
2.94
8.48
2.5
2.0
19.85
20.77
s
0.73
34
133
129
781
1.92
8.34
5.0
2.7
2.48
2.45
mmol/l
1.87
119
704
203
1417
1.81
8.33
4.4
3.6
22.80
75.03
ng/l
0.68
146
971
367
3091
2.16
8.19
8.0
4.4
15.20
14.68
pmol/l
3.26
356
2856
314
2521
1.87
7.87
7.1
4.5
818.43
449.25
e6/l
—
7
40
119
715
1.91
7.80
4.6
3.6
351.75
261.76
ng/l
0.14
95
523
146
938
1.83
7.76
5.1
4.7
—
—
—
0
0
325
2649
1.88
7.62
6.5
4.5
—
2.26
—
0
6
255
1940
1.75
7.49
4.3
2.9
128.11
100.47
ug/l
1.27
241
1807
65
318
2.23
7.42
2.0
3.0
77.12
71.36
e9/l
0.54
47
236
23
65
3.68
7.24
2.3
3.0
4.24
4.80
e9/l
0.47
23
65
102
596
1.93
7.22
4.1
2.8
2.19
2.91
e6/l
0.55
55
276
222
1637
1.72
7.19
2.5
2.1
—
—
—
0
0
25
77
3.38
6.94
3.3
1.6
128.95
129.02
g/l
0.00
20
58
147
975
1.76
6.88
3.8
2.7
340.44
329.76
umol/l
0.61
136
853
70
367
2.08
6.69
2.9
2.4
36.97
35.74
u/l
0.06
60
310
14
18
7.99
6.66
1.1
1.2
211.57
155.81
mmol/24h
0.80
14
18
101
609
1.86
6.43
1.6
1.4
583.33
524.79
titre
0.09
24
142
40
168
2.52
6.42
4.0
3.7
—
—
—
0
0
238
1827
1.66
6.33
4.0
2.7
—
—
estimate
—
0
0
321
2668
1.76
6.32
5.0
3.9
—
0.00
—
0
5
26
91
2.97
5.88
2.5
2.8
59.05
58.97
%
0.01
26
91
27
97
2.90
5.84
1.2
1.2
2.00
18.36
e6/l
1.00
21
73
184
1343
1.64
5.83
3.7
3.1
35.76
30.03
u/l
0.64
169
1270
147
1019
1.67
5.67
1.4
1.3
0.78
1.67
u/ml
1.15
41
283
88
530
1.83
5.57
2.6
2.2
175.28
107.34
ug/g
0.87
76
414
160
1138
1.64
5.56
2.0
1.6
18.76
20.44
nmol/l
0.80
144
949
58
304
2.05
5.53
4.1
3.7
—
—
—
0
0
91
561
1.79
5.32
1.4
1.2
—
—
—
0
0
84
507
1.81
5.27
2.9
3.1
4.99
5.51
e9/l
0.27
75
438
29
115
2.63
5.24
1.8
2.1
2.64
4.47
iu/l
0.79
12
45
76
449
1.84
5.10
3.9
3.0
5.94
6.77
umol/l
0.20
66
396
28
114
2.56
4.81
1.3
1.3
443.82
497.78
mg/l
0.49
28
107
79
481
1.78
4.80
1.6
1.3
—
—
—
0
0
24
93
2.67
4.55
2.2
1.5
36.83
44.29
nmol/l
0.60
24
86
33
150
2.30
4.50
2.3
1.8
3.11
3.90
ug/l
0.12
33
134
114
781
1.62
4.46
1.9
1.7
402.64
11162517.97
pmol/l
0.50
97
654
15
46
3.34
4.22
1.1
1.3
—
—
—
0
0
22
85
2.67
4.20
1.2
1.2
—
—
—
0
0
17
57
3.06
4.17
1.4
1.2
40.20
4.52
u/ml
—
5
25
152
1129
1.53
4.15
4.6
3.2
0.00
0.08
estimate
0.60
57
346
16
52
3.16
4.12
2.0
1.5
—
—
—
0
0
16
52
3.16
4.12
2.0
1.5
—
—
—
0
0
16
52
3.16
4.12
2.0
1.5
—
—
—
0
0
16
52
3.16
4.12
2.0
1.5
—
—
—
0
0
250
2067
1.49
4.01
5.0
3.8
0.00
0.00
estimate
0.50
68
428
253
2105
1.48
3.88
5.1
3.8
0.00
0.74
estimate
0.50
66
408
76
486
1.68
3.86
1.3
1.5
—
—
—
0
0
65
399
1.74
3.82
2.2
4.3
11.13
18.66
ug/l
0.27
51
331
392
3602
1.84
3.81
10.4
6.0
42.48
38.73
mmol/mol
8.51
381
3405
156
1184
1.49
3.78
8.5
6.3
—
—
—
0
0
12
29
4.22
3.73
1.0
1.2
93.58
104.69
pmol/l
0.48
12
29
123
891
1.53
3.71
1.6
1.5
2.25
2.40
g/l
0.39
83
546
10
20
5.09
3.71
1.7
3.5
2176.10
675.70
u/ml
—
10
20
36
184
2.04
3.70
1.9
1.9
7.14
5.19
iu/ml
—
9
47
249
2085
1.45
3.57
5.0
3.8
17.68
7.00
estimate
0.25
75
433
16
57
2.88
3.56
1.3
1.9
—
—
—
0
0
16
57
2.88
3.56
4.8
3.8
0.31
1.35
%
2.39
16
52
13
36
3.69
3.52
4.7
4.1
—
—
—
0
0
392
3619
1.79
3.51
9.1
5.5
1.70
1.87
mu/l
1.90
376
3356
21
88
2.46
3.45
1.2
1.3
—
—
—
0
0
28
134
2.16
3.42
1.3
1.3
—
—
—
0
0
25
115
2.24
3.35
1.3
1.4
—
—
—
0
0
88
605
1.57
3.33
2.0
1.6
1039.58
1176.92
nmol/l
0.82
73
442
203
1653
1.43
3.30
4.2
3.5
6.11
6.20
ph
0.60
124
921
25
116
2.23
3.29
1.4
1.2
80.00
100.00
titre
—
5
16
305
2675
1.46
3.28
5.0
3.3
93.56
45.38
u/l
2.34
294
2519
24
110
2.25
3.25
1.8
3.8
1.76
2.50
ratio
0.38
12
66
13
39
3.40
3.25
1.4
1.4
—
—
—
0
0
404
3782
1.88
3.18
31.0
14.5
22.76
22.60
mg/l
0.04
369
3065
19
79
2.47
3.18
2.8
2.5
139.20
114.72
ug/min
—
10
45
35
188
1.94
3.16
2.0
2.5
—
—
—
0
0
8
16
5.07
3.06
1.1
1.8
—
—
—
0
0
103
747
1.50
3.04
1.7
1.8
—
—
—
0
0
192
1565
1.40
3.03
5.1
3.6
0.00
0.03
estimate
1.39
63
351
5
5
10.09
2.98
1.4
1.4
—
—
—
0
0
17
70
2.49
2.91
1.4
5.2
—
—
—
0
0
29
153
1.96
2.78
2.0
1.9
4472.70
5266.10
u/l
—
9
55
147
1159
1.40
2.76
5.0
3.8
0.00
0.01
estimate
0.74
65
407
74
514
1.53
2.67
1.4
1.3
—
—
—
0
0
12
42
2.91
2.56
1.2
1.3
—
—
—
0
0
50
321
1.63
2.52
3.5
2.4
6.12
6.11
ph
0.02
38
208
50
322
1.62
2.49
1.3
1.3
153.29
144.02
u/ml
0.05
19
137
25
131
1.96
2.46
3.9
3.3
360.37
205.94
mg/l
0.41
16
49
11
38
2.94
2.43
1.5
2.1
8.45
11.17
%
1.34
11
38
9
27
3.38
2.40
3.9
3.1
988.56
770.30
mg
—
9
27
13
52
2.55
2.38
1.9
2.7
—
—
—
0
0
10
33
3.08
2.37
1.1
1.3
1343.00
2107.00
e6/l
—
5
20
63
438
1.51
2.27
1.6
1.7
—
—
—
0
0
9
29
3.15
2.23
1.1
1.3
—
—
—
0
0
69
495
1.47
2.14
1.9
1.4
—
—
—
0
0
12
49
2.49
2.12
1.1
1.3
—
—
—
0
0
11
43
2.60
2.09
1.7
2.2
—
—
—
0
0
86
646
1.41
2.09
1.6
1.6
—
—
—
0
0
9
32
2.85
2.01
1.1
1.7
—
—
—
0
0
51
349
1.52
1.99
1.1
1.2
—
—
—
0
0
5
11
4.58
1.94
1.2
1.8
37.60
26.09
%
—
5
11
9
34
2.68
1.87
1.0
1.2
—
—
—
0
0
11
46
2.43
1.86
1.3
2.3
32.45
32.65
pg
0.04
11
46
23
386
0.57
1.86
1.3
1.4
—
—
—
0
0
14
67
2.13
1.78
1.4
1.4
292.22
247.49
u/ml
—
9
36
6
18
3.36
1.75
1.0
1.8
1.71
0.91
nmol/l
—
6
11
9
36
2.53
1.75
1.0
1.2
—
—
—
0
0
26
157
1.70
1.70
2.9
3.3
24.62
1468.08
u/ml
0.93
21
133
100
797
1.33
1.68
1.4
1.3
5.86
9.32
u/ml
0.31
37
304
52
371
1.46
1.68
2.1
2.1
0.00
0.03
estimate
—
10
87
41
280
1.51
1.64
1.4
1.4
29.47
43.72
au/ml
—
6
23
8
32
2.53
1.60
1.0
1.2
—
—
—
0
0
8
33
2.45
1.54
1.1
1.3
—
—
—
0
0
5
15
3.36
1.52
1.6
1.7
—
—
—
0
0
5
127
0.39
1.52
12.6
7.9
—
—
—
0
0
6
21
2.88
1.51
1.2
1.3
17.50
7.67
mm/h
—
6
21
7
151
0.45
1.46
1.0
1.2
1.12
0.91
g/l
—
7
151
105
866
1.28
1.37
1.4
1.3
27.82
30.98
iu/ml
0.10
25
262
7
147
0.47
1.34
1.0
1.2
1.56
1.58
g/l
—
7
147
9
44
2.07
1.27
1.2
1.1
—
—
—
0
0
28
187
1.53
1.27
1.6
1.5
0.33
0.38
mg/l
0.15
12
79
14
77
1.85
1.27
1.3
1.4
—
—
—
0
0
24
155
1.58
1.26
1.8
1.6
13.92
8.49
u/ml
—
5
33
13
70
1.88
1.25
1.8
1.5
—
—
—
0
0
5
19
2.65
1.22
1.6
6.1
15.30
17.01
%
—
5
19
404
3909
1.43
1.21
26.7
12.9
—
—
—
0
0
6
26
2.33
1.19
2.2
4.8
7.20
7.87
mmol/l
—
6
26
191
1708
1.21
1.17
2.2
1.9
1.59
1.33
mmol/l
2.84
165
1443
8
40
2.02
1.12
1.4
1.0
—
—
—
0
0
8
41
1.97
1.09
1.3
1.2
6.22
6.01
mmol/l
—
8
36
10
52
1.94
1.07
1.0
1.2
—
—
—
0
0
12
68
1.79
1.01
1.6
1.4
—
—
—
0
0
7
35
2.02
1.00
1.4
1.6
—
—
—
0
0
49
382
1.32
0.99
1.6
1.4
—
—
—
0
0
0
30
0.00
0.97
0.0
1.1
—
—
—
0
0
43
332
1.33
0.94
5.9
3.9
7.39
7.34
ph
1.92
33
223
16
102
1.59
0.91
1.4
1.2
—
—
—
0
0
128
1131
1.19
0.86
1.5
1.4
—
—
—
0
0
40
314
1.30
0.80
1.3
1.4
—
—
—
0
0
5
97
0.51
0.79
1.0
1.1
—
—
—
0
0
380
3684
1.24
0.78
7.5
5.0
6.17
5.86
mmol/l
3.21
366
3414
30
227
1.35
0.77
1.2
1.1
—
—
—
0
0
5
24
2.10
0.74
1.2
1.0
—
—
—
0
0
7
39
1.81
0.73
1.0
1.1
—
—
—
0
0
7
39
1.81
0.73
1.3
1.1
—
—
—
0
0
9
56
1.62
0.72
1.6
1.1
—
—
—
0
0
7
40
1.76
0.71
3.0
2.7
—
—
—
0
0
16
110
1.47
0.69
1.3
1.2
—
—
—
0
0
12
79
1.53
0.63
4.9
4.7
—
—
—
0
0
5
30
1.67
0.61
1.2
1.0
—
—
—
0
0
8
51
1.58
0.60
1.8
2.8
—
—
—
0
0
388
3790
1.21
0.59
6.4
4.9
1.41
1.52
mmol/l
4.94
369
3518
29
229
1.29
0.58
1.1
1.1
—
—
—
0
0
8
54
1.49
0.57
1.3
1.1
—
—
—
0
0
6
37
1.63
0.55
1.0
1.2
—
—
—
0
0
15
108
1.40
0.53
2.0
1.9
—
—
—
0
0
389
3807
1.19
0.53
6.5
5.0
4.56
4.73
mmol/l
2.55
370
3554
370
3607
1.17
0.53
5.6
4.2
1.56
1.25
mmol/l
6.15
350
3324
18
237
0.75
0.53
1.7
1.7
—
—
—
0
0
394
3862
1.20
0.52
7.3
5.7
2.62
2.77
mmol/l
2.65
373
3595
6
40
1.51
0.52
1.8
2.4
—
—
—
0
0
17
129
1.33
0.46
1.6
1.5
—
—
—
0
0
11
152
0.72
0.45
1.3
1.3
237.62
269.61
miu/ml
—
5
77
0
16
0.00
0.41
0.0
1.0
—
5.47
—
0
10
10
138
0.72
0.41
1.3
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
1405.21
—
0
19
5
37
1.36
0.37
1.2
1.2
0.02
0.39
u/ml
—
5
14
16
126
1.28
0.35
3.6
2.8
—
—
—
0
0
19
156
1.23
0.31
1.6
1.5
—
—
—
0
0
7
56
1.25
0.29
3.4
3.4
0.70
0.80
nmol/l
—
7
46
13
104
1.26
0.26
1.4
1.7
—
—
—
0
0
20
169
1.19
0.26
1.5
1.2
—
—
—
0
0
29
327
0.88
0.23
1.9
1.9
3.63
3.43
mmol/l
0.55
22
233
36
398
0.90
0.22
1.8
1.6
—
—
—
0
0
5
41
1.22
0.22
4.4
2.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
0.02
—
0
11
77
817
0.93
0.20
6.6
5.7
2.27
2.48
ug/l
0.14
72
724
0
14
0.00
0.20
0.0
1.3
—
0.00
—
0
14
49
454
1.09
0.19
1.6
1.5
—
—
—
0
0
10
81
1.24
0.19
1.2
1.7
—
—
—
0
0
152
1569
0.95
0.17
4.5
3.1
—
—
—
0
0
23
206
1.12
0.16
2.2
2.1
0.00
0.01
estimate
—
5
74
8
72
1.11
0.16
1.1
1.1
—
—
—
0
0
19
168
1.14
0.16
1.6
1.5
—
—
—
0
0
19
168
1.14
0.16
2.3
1.8
—
—
—
0
0
95
918
1.04
0.12
5.3
3.8
1.02
1.02
kg/l
0.01
69
612
6
55
1.09
0.09
1.0
1.3
—
—
—
0
0
47
491
0.95
0.08
3.8
3.2
0.81
0.75
ug/l
0.15
32
318
27
287
0.94
0.08
1.1
1.3
—
—
—
0
0
18
166
1.09
0.08
1.6
1.5
—
—
—
0
0
18
166
1.09
0.08
1.6
1.5
—
—
—
0
0
6
73
0.82
0.07
1.2
1.8
—
—
—
0
0
18
167
1.08
0.07
1.6
1.5
—
—
—
0
0
20
188
1.07
0.05
1.1
1.1
—
—
—
0
0
413
4136
0.97
0.00
45.7
22.4
4.43
4.48
e12/l
0.98
408
4059
413
4136
0.97
0.00
45.8
22.5
7.76
6.62
e9/l
19.37
408
4056
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
6
62
0.97
0.00
1.3
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
0.40
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.05
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
89
0.90
-0.00
1.5
3.3
16.38
27.14
u/ml
—
8
89
0
5
0.00
-0.00
0.0
2.6
—
3.00
—
0
5
0
5
0.00
-0.00
0.0
2.4
—
52.00
—
0
5
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.8
—
10.40
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.6
—
44.20
—
0
5
0
9
0.00
-0.00
0.0
3.6
—
8.74
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_CUSHING and mortality.

Females

Parameter HR [95% CI] p-value
E4_CUSHING 3.602 [2.92, 4.44] < 0.001
Birth year 0.996 [0.99, 1.0] 0.334

During the follow-up period (1.1.1998 — 31.12.2019), 240 out of 978 females with E4_CUSHING died.

Males

Parameter HR [95% CI] p-value
E4_CUSHING 3.754 [2.69, 5.23] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 147 out of 409 males with E4_CUSHING died.

Mortality risk

Mortality risk for people of age

years, who have E4_CUSHING.

N-year risk Females Males
1 0.26% 0.602%
5 2.009% 4.136%
10 5.011% 10.054%
15 9.495% 19.573%
20 16.424% 30.551%

Relationships between endpoints

↥

Index endpoint: E4_CUSHING – Cushing syndrome

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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