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Pituitary-dependent Cushing's disease

Endpoint Browser PheWeb

E4_PITUITARY_DEPENDENT_CUSHINGS_DISEASE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E24.0
  • Cause of death: ICD-10 — E24.0

2 out of 7 registries used, show all original rules.

131

4. Check minimum number of events

None

131

5. Include endpoints

None

131

6. Filter based on genotype QC (FinnGen only)

112

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 112 88 24
Unadjusted period prevalence (%) 0.03 0.03 0.01
Median age at first event (years) 46.27 44.68 52.09

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
116
Matched controls
1160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
+∞
164.3
115
*
H02AB09
ATC
hydrocortisone; systemic
221.4
159.7
81
12
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
252.3
64.5
61
5
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
311.4
55.3
52
*
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
+∞
53.3
47
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
270.1
50.3
48
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
35.5
28.9
37
15
H02AA02
ATC
fludrocortisone; oral
+∞
27.1
25
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
26.0
24
*
V04CD01
ATC
metyrapone; oral
+∞
26.0
24
*
E24.8
ICD-10 Finland
Other Cushing syndrome
+∞
22.6
21
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
141.9
22.5
23
*
E89.6
ICD-10 Finland
Postprocedural adrenocortical(-medullary) hypofunction
+∞
21.5
20
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.6
20.7
31
47
C03DA01
ATC
spironolactone; oral
6.8
17.8
34
67
H03AA01
ATC
levothyroxine sodium; systemic
4.7
15.3
58
204
BCA41
NOMESCO Finland
Endoscopic bilateral adrenalectomy
+∞
13.8
13
*
ZXC86
NOMESCO Finland
Use of endoscopic device
157.7
13.8
14
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
12.7
12
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.8
12.7
37
104
E23.00
ICD-10 Finland
Panhypopituitarism
145.0
12.7
13
*
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
21.8
12.0
17
9
AA4WT
NOMESCO Finland
Selective blood sample from sinus petrosus inferior
+∞
11.6
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.7
10.6
50
197
E24
ICD-10 Finland
Cushing syndrome
+∞
10.6
10
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
10.6
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.9
10.2
39
133
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
60.2
9.8
11
*
N04BC06
ATC
cabergoline; oral
60.2
9.8
11
*
E23.03
ICD-10 Finland
Lack of ACTH
108.5
9.6
10
*
A10BA02
ATC
metformin; oral
3.4
9.1
46
186
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
96.8
8.5
9
*
2550C
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING E HYPERSECRETIO HYPOFYSEOS]
+∞
8.4
8
*
ZXC95
NOMESCO Finland
Use of surgical navigator
36.1
8.2
10
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.7
7.9
20
49
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
7.5
26
81
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
85.3
7.5
8
*
WX882
NOMESCO Finland
High dependency care
21.7
7.3
10
5
C03CA01
ATC
furosemide; systemic
3.1
7.2
39
162
A02BC02
ATC
pantoprazole; systemic
3.6
7.1
95
646
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.7
6.9
17
29
C08CA01
ATC
amlodipine; oral
2.8
6.9
52
258
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.7
6.7
24
76
H01AC01
ATC
somatropin; parenteral
73.7
6.5
7
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
73.7
6.5
7
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
73.7
6.5
7
*
2550X
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING NUD]
+∞
6.3
6
*
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
6.3
6
*
E24.3
ICD-10 Finland
Ectopic ACTH syndrome
+∞
6.3
6
*
E24.1
ICD-10 Finland
Nelson syndrome
+∞
6.3
6
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
6.3
6
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
7.4
6.3
14
21
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
6.2
56
302
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.9
6.2
39
175
L28
ICPC
Limited function/disability (L)
3.2
6.1
29
110
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.8
6.0
20
60
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
6.0
37
163

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
75
8
259.03
80.49
8.5
1.5
131.31
17.21
ng/l
—
75
8
55
7
146.69
54.95
5.3
1.0
200.56
46.57
nmol/24h
—
55
7
101
504
8.76
18.15
11.3
7.7
1.23
1.22
mmol/l
0.67
88
444
30
63
6.07
14.50
10.1
7.5
24.17
24.64
mmol/l
0.25
30
63
38
107
4.79
13.07
11.3
8.1
0.27
1.32
mmol/l
1.20
29
89
37
106
4.66
12.39
11.5
8.1
7.42
7.42
ph
0.00
25
66
70
323
3.94
11.98
5.7
5.0
7.41
7.40
ph
1.39
59
225
13
5
28.94
10.05
2.7
2.0
72.38
84.60
ug/l
—
13
5
30
89
4.20
9.40
1.3
1.3
—
—
—
0
0
45
185
3.34
8.64
3.4
3.0
499.65
517.91
mosm/kgh2o
0.19
38
168
37
136
3.53
8.46
3.5
7.0
0.95
1.04
mmol/l
1.08
37
124
36
141
3.25
7.34
12.1
7.0
105.69
104.61
mmol/l
0.80
36
141
12
12
10.99
6.71
1.4
1.8
—
—
nmol/l
—
0
0
40
175
2.96
6.68
2.8
3.2
0.79
0.81
mmol/l
0.41
40
169
15
28
5.99
5.77
2.1
3.8
7.42
7.43
ph
0.27
15
28
116
1039
+∞
5.10
36.8
16.0
3.90
3.93
mmol/l
0.67
116
1021
116
1037
+∞
5.10
37.1
15.8
139.73
139.85
mmol/l
0.22
116
1021
25
97
3.01
5.05
1.6
3.8
7.39
7.39
ph
0.06
16
57
23
86
3.09
4.94
15.8
8.3
—
—
—
0
0
81
559
2.49
4.86
6.3
6.1
0.04
0.04
e9/l
0.06
72
487
82
570
2.50
4.83
6.7
6.0
1.85
1.87
e9/l
0.13
73
509
87
626
2.56
4.67
8.0
10.8
5.01
3.95
e9/l
2.95
80
552
7
5
14.76
4.63
1.6
1.6
23.06
5.66
mu/l
—
7
5
82
576
2.45
4.62
6.4
6.5
0.16
0.19
e9/l
1.11
72
508
80
556
2.41
4.62
6.4
6.1
0.63
0.54
e9/l
2.36
71
488
8
8
10.62
4.59
1.1
5.3
56.38
310.50
nmol/l
—
8
8
13
30
4.74
4.28
2.4
1.6
39.54
38.07
nmol/l
0.05
13
30
11
21
5.67
4.26
3.0
3.1
7.18
9.85
pmol/l
0.32
11
21
10
18
5.97
4.07
2.3
2.9
—
—
—
0
0
42
235
2.23
3.94
4.4
4.0
—
—
—
0
0
71
490
2.16
3.88
3.8
2.7
—
—
estimate
—
0
0
69
471
2.15
3.88
14.9
11.6
0.01
0.00
e9/l
0.79
58
378
16
56
3.15
3.80
21.1
10.3
95.61
94.20
%
0.79
16
56
15
51
3.23
3.73
3.0
3.6
24.51
24.30
mmol/l
0.11
15
51
28
134
2.44
3.73
2.1
1.6
—
—
—
0
0
64
435
2.05
3.53
18.5
9.8
1.16
1.16
inr
0.00
56
353
18
71
2.82
3.49
1.3
1.2
—
—
—
0
0
55
355
2.04
3.48
3.8
3.2
7.84
7.69
mmol/l
0.08
50
298
16
60
2.93
3.39
21.1
9.7
1.06
1.18
%
0.27
16
60
16
60
2.93
3.39
20.6
9.6
0.50
0.63
%
0.93
16
60
52
335
2.00
3.26
3.3
2.2
—
—
—
0
0
32
172
2.19
3.24
2.9
2.7
12.02
14.19
umol/l
1.02
32
157
53
345
1.99
3.22
7.0
5.8
—
—
—
0
0
9
20
4.78
3.18
2.6
3.2
8.68
9.09
kpa
—
9
20
9
20
4.78
3.18
2.6
3.2
4.91
4.90
kpa
—
9
20
41
246
2.03
3.11
1.5
1.8
0.73
1.15
mg/l
0.80
30
202
46
288
1.99
3.10
3.5
3.1
0.19
0.23
e6/l
0.10
35
207
20
89
2.51
3.08
5.5
4.0
0.00
0.05
%
—
9
22
13
48
2.92
2.82
4.3
4.6
—
—
—
0
0
19
86
2.45
2.82
5.2
3.4
0.22
1.05
%
—
9
22
12
40
3.23
2.79
4.2
4.2
36.98
36.95
°c
0.23
12
40
27
144
2.14
2.76
2.4
2.0
—
—
—
0
0
86
682
2.01
2.74
5.4
4.5
—
65.00
—
0
17
10
30
3.55
2.67
2.5
2.3
1.83
1.49
mg/l
—
10
24
33
193
1.99
2.64
2.1
1.7
453.89
482.77
pmol/l
0.22
28
163
9
25
3.81
2.63
3.1
3.5
63.33
61.46
%
—
9
25
8
20
4.21
2.62
2.4
4.0
5.37
4.69
e9/l
—
8
20
37
228
1.91
2.54
3.0
2.9
5.04
6.29
e6/l
0.25
32
213
32
188
1.97
2.52
3.1
3.4
33.23
64.69
ng/l
0.42
26
131
7
16
4.58
2.51
1.7
1.5
9.29
10.56
mmol/l
—
7
16
8
21
4.01
2.51
1.6
2.5
1.80
1.59
mmol/l
—
8
21
11
38
3.09
2.49
5.5
2.6
—
—
—
0
0
62
459
1.75
2.29
2.6
2.1
—
—
—
0
0
5
9
5.75
2.23
1.0
1.1
251.60
157.07
mmol/24h
—
5
9
5
9
5.75
2.23
1.0
1.4
104.60
90.56
pmol/l
—
5
9
40
263
1.80
2.21
4.8
5.6
—
—
—
0
0
55
397
1.73
2.20
4.6
4.2
31.24
41.44
e6/l
0.21
42
261
6
14
4.46
2.18
1.2
1.4
—
—
—
0
0
48
337
1.72
2.10
3.7
3.4
21.48
38.49
e6/l
0.42
37
253
14
64
2.35
2.04
2.1
2.1
4.99
4.94
ug/l
0.01
14
55
18
92
2.13
2.03
5.3
3.6
0.75
0.78
%
—
8
29
17
85
2.17
2.02
5.5
3.7
0.00
0.14
%
—
7
22
16
79
2.19
1.96
3.8
3.5
—
—
—
0
0
40
273
1.71
1.91
1.3
1.5
2.38
2.26
g/l
0.11
25
166
52
381
1.66
1.90
3.8
3.4
18.10
19.55
ng/l
0.20
39
239
26
156
1.86
1.90
1.2
1.2
—
—
—
0
0
45
321
1.66
1.81
4.1
3.4
12.68
68.21
mg/l
3.04
36
202
45
326
1.62
1.68
4.8
4.2
1.79
11.21
mg/mmol
2.95
35
196
46
336
1.61
1.66
3.3
2.8
—
—
—
0
0
5
15
3.43
1.54
1.2
1.3
—
—
—
0
0
6
137
0.41
1.52
1.5
1.3
—
—
—
0
0
68
552
1.56
1.52
4.2
3.3
120.60
82.10
ug/l
0.57
68
523
25
159
1.73
1.51
2.8
3.0
2.51
3.51
e6/l
0.27
14
71
60
482
1.51
1.36
2.1
1.9
1.60
1.36
mmol/l
1.26
55
411
40
296
1.54
1.32
1.5
1.3
1.18
1.38
u/ml
0.14
12
89
8
34
2.45
1.32
1.1
1.1
2.25
23.71
e6/l
—
8
24
8
35
2.38
1.30
1.3
1.2
89.75
196.38
e6/l
—
8
26
6
25
2.47
1.26
1.3
3.1
11.22
11.12
mg/l
—
6
25
6
25
2.47
1.26
3.5
4.0
3.95
3.97
mmol/l
—
6
25
33
243
1.50
1.10
1.3
1.3
37.16
26.09
iu/ml
—
10
84
5
22
2.33
1.04
1.4
1.5
—
—
—
0
0
7
35
2.06
1.02
1.1
1.3
—
—
—
0
0
9
50
1.87
0.99
1.7
2.3
2.07
1.57
g/l
—
9
43
116
1130
+∞
0.99
41.0
22.6
40.83
40.32
%
0.75
116
1124
116
1130
+∞
0.99
38.7
22.2
91.28
90.87
fl
0.39
116
1124
116
1130
+∞
0.99
39.1
22.4
134.77
134.57
g/l
0.06
116
1124
116
1130
+∞
0.99
38.6
22.1
30.11
30.25
pg
0.33
116
1124
39
304
1.43
0.97
1.4
1.5
—
—
—
0
0
39
307
1.41
0.91
4.2
3.8
0.00
0.00
estimate
-0.00
20
110
6
30
2.05
0.88
3.5
6.0
1.20
1.59
mmol/l
—
6
30
57
482
1.36
0.86
2.0
2.1
97.53
101.67
pmol/l
0.27
29
244
10
58
1.79
0.82
3.0
3.4
—
—
—
0
0
40
323
1.36
0.79
3.9
3.4
—
—
—
0
0
16
108
1.56
0.78
1.0
1.2
—
—
—
0
0
5
24
2.13
0.75
1.2
1.3
—
—
—
0
0
5
25
2.04
0.73
1.2
1.1
—
—
—
0
0
111
1068
1.91
0.70
23.1
12.5
—
—
—
0
0
8
52
1.58
0.61
1.0
1.2
—
—
—
0
0
12
81
1.54
0.60
1.6
3.2
62.05
66.57
g/l
1.11
12
76
28
224
1.33
0.58
1.2
1.3
1.17
6.59
u/ml
1.45
11
88
9
60
1.54
0.56
1.0
1.3
—
—
—
0
0
13
91
1.48
0.56
1.2
2.6
8.59
9.77
g/l
1.00
13
85
11
74
1.54
0.55
1.2
2.0
1.27
1.59
g/l
0.29
11
68
9
62
1.49
0.54
1.0
1.3
—
—
—
0
0
9
64
1.44
0.53
1.2
3.1
—
—
—
0
0
53
472
1.23
0.46
3.2
3.4
6.15
6.18
ph
0.07
33
262
38
327
1.24
0.45
7.9
7.3
—
—
—
0
0
17
131
1.35
0.45
1.4
1.4
—
—
—
0
0
49
435
1.22
0.44
5.3
3.6
0.00
0.01
estimate
0.50
18
99
38
329
1.23
0.43
5.7
3.4
0.00
0.01
estimate
0.49
16
94
12
88
1.41
0.42
1.3
1.2
52.17
127.84
u/ml
2.12
12
83
13
97
1.38
0.41
1.5
1.2
350.10
121.69
u/ml
—
6
40
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
8
60
1.36
0.41
1.0
1.3
—
—
—
0
0
8
60
1.36
0.41
1.0
1.3
—
—
—
0
0
8
61
1.33
0.40
1.0
1.3
—
—
—
0
0
5
35
1.45
0.40
1.0
1.4
—
—
—
0
0
6
42
1.45
0.36
1.2
1.6
—
—
—
0
0
62
571
1.18
0.36
5.1
3.8
0.00
0.00
estimate
-0.00
22
116
7
54
1.32
0.31
1.6
2.4
—
—
—
0
0
16
130
1.27
0.30
1.3
1.2
—
—
—
0
0
19
158
1.24
0.30
1.3
1.6
—
—
—
0
0
7
57
1.24
0.29
1.0
1.1
—
—
—
0
0
16
131
1.26
0.29
1.3
1.4
—
—
—
0
0
62
582
1.14
0.25
5.1
3.8
0.00
13.65
estimate
0.50
22
119
6
84
0.70
0.25
2.3
1.8
—
—
—
0
0
14
117
1.22
0.21
1.2
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
46.62
—
0
10
0
12
0.00
0.21
0.0
12.4
—
0.64
—
0
12
0
12
0.00
0.21
0.0
3.2
—
47.67
—
0
6
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
19.65
—
0
13
0
13
0.00
0.21
0.0
2.0
—
0.62
—
0
13
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
17.4
—
871.21
—
0
14
48
450
1.11
0.18
4.4
3.2
—
—
—
0
0
28
254
1.13
0.18
1.9
2.0
—
—
—
0
0
61
580
1.11
0.18
5.2
3.8
0.00
0.00
estimate
-0.00
19
109
15
129
1.19
0.18
1.6
1.8
—
—
—
0
0
111
1095
1.32
0.17
17.4
11.6
26.39
24.72
u/l
0.64
111
1073
23
253
0.89
0.15
4.5
3.7
1.01
1.02
kg/l
0.54
15
155
11
95
1.17
0.12
1.3
1.4
—
—
—
0
0
18
165
1.11
0.09
6.3
5.2
2.08
1.88
ug/l
0.14
18
145
8
73
1.10
0.08
1.1
1.2
—
—
—
0
0
22
209
1.06
0.05
1.7
1.7
—
—
—
0
0
14
148
0.94
0.02
1.8
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
6
67
0.89
0.00
1.2
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
229.20
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
25.0
—
7.10
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
204.17
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
61.80
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
8.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.1
—
0.63
—
0
8
0
9
0.00
-0.00
0.0
6.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
0.60
—
0
5
0
8
0.00
-0.00
0.0
1.9
—
155.75
—
0
8
0
5
0.00
-0.00
0.0
3.8
—
55.70
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
11
110
1.00
-0.00
1.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
259.13
—
0
6

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: E4_PITUITARY_DEPENDENT_CUSHINGS_DISEASE – Pituitary-dependent Cushing's disease

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).