Sequelae of hyperalimentation

E4_HYPERALISEQ

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E68
  • Cause of death: ICD-10 E68

2 out of 7 registries used, show all original rules.

74

4. Check minimum number of events

None

74

5. Include endpoints

None

74

6. Filter based on genotype QC (FinnGen only)

63

Control definitions (FinnGen only)

Control exclude
E4_OBESITY_HYPER

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E65-E68
Name in latin
Sequelae hyperalimentationis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 324 197 127
Only index persons 306 189 117
Unadjusted period prevalence (%)
Whole population 0.00 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population - 49.24 58.24
Only index persons 52.05 48.89 57.17

-FinnGen-

Key figures

All Female Male
Number of individuals 63 43 20
Unadjusted period prevalence (%) 0.01 0.02 0.01
Median age at first event (years) 52.59 48.89 60.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
65
Matched controls
650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E68
ICD-10 Finland
Sequelae of hyperalimentation
+∞
93.3
65
*
E66.8
ICD-10 Finland
Other obesity
254.7
30.6
29
*
E66.01
ICD-10 Finland
Obesity due to excess calories
32.1
24.5
33
20
E66.00
ICD-10 Finland
Metabolic syndrome
50.4
18.0
21
6
E66.9
ICD-10 Finland
Obesity, unspecified
104.0
15.3
16
*
QBJ30
NOMESCO Finland
Correction of abdominal apron
+∞
14.0
13
*
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
11.8
11
*
SPAT1262
SPAT
Handing over of treatment supplies
7.1
11.2
21
41
T82
ICPC
Obesity
23.8
10.9
15
8
M04AA01
ATC
allopurinol; systemic
6.3
9.3
19
40
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
8.5
8
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
20.6
8.4
12
7
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.5
7.7
27
89
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
7.2
7.7
19
35
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
18.5
7.5
11
7
103
Kela drug reimbursment
Diabetes, insulin-treated
4.4
7.5
27
91
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.3
6.9
24
78
310
Kela drug reimbursment
Orlistat, sibutramine and other major and expensive medicines used to treat obesity
+∞
6.3
6
*
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
5.0
6.3
16
40
E66
ICD-10 Finland
Obesity
11.7
6.3
11
11
C03CA01
ATC
furosemide; systemic
3.7
6.2
29
115
N02AX02
ATC
tramadol; systemic, rectal
3.7
6.2
40
196
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
3.8
6.2
28
109
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
12.8
6.0
10
9

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
82
4.62
7.91
2.1
1.6
1071.33
1201.39
nmol/l
0.31
21
66
46
230
4.42
7.31
3.0
1.9
102.29
99.14
pmol/l
0.14
31
114
34
161
3.33
5.39
6.2
3.5
7.25
6.46
mg/mmol
0.07
20
104
34
162
3.30
5.32
5.1
3.0
6.60
8.08
mmol/l
0.95
27
140
17
53
3.99
5.04
5.3
1.6
—
—
—
0
0
32
154
3.12
4.82
5.3
3.0
33.26
34.27
mg/l
0.02
21
98
22
85
3.40
4.75
2.7
2.5
2.58
2.34
g/l
1.25
22
79
23
93
3.28
4.61
3.0
2.4
10.87
13.28
umol/l
1.36
23
87
29
146
2.78
3.86
3.3
3.1
334.67
333.44
umol/l
0.02
24
131
33
179
2.71
3.78
3.0
2.3
—
—
—
0
0
18
70
3.17
3.77
6.2
6.9
1.16
1.03
mmol/l
0.95
18
62
19
80
2.94
3.46
2.9
1.7
—
—
—
0
0
7
10
7.68
3.46
1.9
1.4
—
—
—
0
0
27
139
2.61
3.36
4.8
4.7
—
—
—
0
0
30
166
2.50
3.18
2.4
1.5
21.53
20.68
nmol/l
0.10
25
144
40
253
2.51
3.18
9.1
12.3
1.21
1.19
inr
0.08
34
209
46
315
2.57
3.01
5.2
4.7
7.40
6.46
mmol/l
1.49
46
291
40
266
2.31
2.67
3.8
2.7
—
—
estimate
—
0
0
10
32
3.50
2.57
1.8
1.2
—
—
—
0
0
39
261
2.24
2.51
9.3
7.2
1.20
1.22
mmol/l
0.72
32
225
24
137
2.19
2.24
1.3
1.3
2.73
2.28
g/l
0.81
18
84
6
14
4.60
2.20
1.2
1.0
—
—
—
0
0
55
444
2.55
2.02
4.6
4.7
14.39
14.61
pmol/l
0.26
48
416
5
12
4.41
1.86
2.4
1.6
10.90
5.28
pmol/l
—
5
12
8
32
2.71
1.66
1.4
1.3
—
—
—
0
0
31
213
1.87
1.65
5.1
4.2
80.54
30.19
ng/l
0.53
25
134
7
26
2.89
1.63
11.9
3.2
—
—
—
0
0
29
197
1.85
1.58
6.9
6.0
—
—
—
0
0
7
27
2.78
1.56
8.3
8.0
95.70
95.50
%
—
7
27
54
451
2.17
1.52
10.4
9.1
91.31
75.42
u/l
2.33
54
427
7
28
2.68
1.50
3.6
2.4
—
—
—
0
0
7
29
2.58
1.43
8.0
7.4
0.41
0.67
%
—
7
29
6
24
2.65
1.33
1.0
1.8
0.25
0.24
g/l
—
6
24
27
189
1.73
1.29
5.4
3.7
—
—
—
0
0
8
37
2.32
1.26
8.5
10.1
—
—
—
0
0
8
38
2.26
1.23
1.1
2.5
—
—
—
0
0
23
157
1.72
1.18
1.3
1.3
0.87
1.57
u/ml
—
7
41
7
30
2.49
1.16
1.1
1.1
—
—
—
0
0
14
83
1.88
1.12
1.5
1.5
144.00
514.67
titre
—
5
30
9
45
2.16
1.10
1.0
1.2
—
—
—
0
0
59
530
2.22
1.07
5.4
4.0
1.57
1.26
mmol/l
1.37
54
498
14
85
1.82
1.05
1.1
1.3
—
—
—
0
0
6
27
2.34
0.96
1.2
1.1
—
—
—
0
0
6
29
2.17
0.92
9.5
7.6
0.80
1.11
%
—
6
29
6
31
2.03
0.87
1.0
2.3
—
5.08
—
0
6
13
82
1.73
0.86
1.4
1.2
—
—
—
0
0
11
66
1.80
0.85
1.2
1.2
—
—
—
0
0
5
24
2.17
0.76
1.2
1.0
—
—
—
0
0
5
24
2.17
0.76
1.0
1.8
1.50
1.09
g/l
—
5
24
21
155
1.52
0.76
3.1
3.1
0.14
0.41
e6/l
0.89
16
119
9
58
1.64
0.73
7.3
5.8
0.57
1.38
mmol/l
—
9
45
24
184
1.48
0.72
2.9
3.3
12.52
354.24
e6/l
0.51
18
148
20
259
0.67
0.71
4.2
2.8
—
—
—
0
0
10
64
1.66
0.63
9.1
6.1
103.30
104.69
mmol/l
—
10
64
30
246
1.41
0.62
2.0
1.8
1.74
1.35
mmol/l
0.80
24
211
6
37
1.68
0.57
8.3
4.8
24.83
26.02
mmol/l
—
6
37
9
62
1.52
0.56
1.6
1.8
—
—
—
0
0
21
167
1.38
0.50
2.8
2.6
—
—
—
0
0
0
15
0.00
0.42
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
5
34
1.51
0.41
1.2
2.1
—
—
—
0
0
19
154
1.33
0.40
3.3
3.0
—
—
estimate
—
0
0
11
82
1.41
0.37
1.5
1.5
—
—
—
0
0
25
213
1.28
0.37
3.8
3.9
13.07
40.79
e6/l
0.88
19
151
6
46
1.33
0.34
1.0
1.3
12.50
25.28
iu/l
—
6
38
7
56
1.28
0.30
3.9
3.6
—
—
—
0
0
21
243
0.80
0.30
3.7
3.9
0.00
0.00
estimate
—
6
64
57
547
1.34
0.23
6.6
4.7
6.62
5.82
mmol/l
2.36
52
517
0
11
0.00
0.21
0.0
1.8
—
9.82
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
30.65
—
0
10
0
10
0.00
0.21
0.0
2.5
—
90.69
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
0.12
—
0
7
0
12
0.00
0.21
0.0
2.3
—
8.02
—
0
12
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
12.48
—
0
9
13
110
1.23
0.19
1.5
2.0
—
—
—
0
0
7
59
1.21
0.19
1.3
1.2
—
—
—
0
0
7
62
1.14
0.18
2.9
1.6
—
—
—
0
0
18
162
1.15
0.13
1.7
1.5
—
—
—
0
0
7
66
1.07
0.08
1.4
1.3
—
—
—
0
0
6
74
0.79
0.08
1.2
1.7
—
—
—
0
0
18
192
0.91
0.06
3.3
3.5
0.00
0.00
estimate
—
6
64
33
318
1.08
0.06
4.0
4.1
0.00
0.00
estimate
—
8
73
26
250
1.07
0.04
3.8
3.4
5.97
6.14
ph
0.40
15
139
32
312
1.05
0.02
4.1
4.0
0.00
0.00
estimate
—
7
76
11
104
1.07
0.01
1.5
1.6
—
—
—
0
0
17
176
0.95
0.00
4.1
4.0
0.00
0.00
estimate
—
7
74
18
181
0.99
0.00
5.9
6.8
—
—
—
0
0
24
239
1.01
0.00
2.5
2.0
—
—
—
0
0
15
153
0.97
0.00
4.7
5.8
—
—
—
0
0
32
315
1.03
0.00
3.8
4.0
0.00
0.00
estimate
—
8
77
0
6
0.00
0.00
0.0
1.0
—
249.67
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
0.64
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
6.68
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
150.75
—
0
8
0
8
0.00
-0.00
0.0
4.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
9.22
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
313.40
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
16.16
—
0
5
0
7
0.00
-0.00
0.0
3.0
—
2.30
—
0
7
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
0.62
—
0
5
0
5
0.00
-0.00
0.0
2.8
—
73.60
—
0
5
0
7
0.00
-0.00
0.0
2.9
—
3.83
—
0
7
60
593
1.15
-0.00
17.4
12.4
30.47
25.50
u/l
1.45
60
582
0
9
0.00
-0.00
0.0
1.2
—
14.67
—
0
9
0
7
0.00
-0.00
0.0
2.9
—
105.57
—
0
7
0
9
0.00
-0.00
0.0
2.8
—
15.98
—
0
9
0
5
0.00
-0.00
0.0
1.4
—
37.56
—
0
5
0
7
0.00
-0.00
0.0
2.9
—
1.21
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
91.60
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
9.06
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.4
—
33.00
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
1.63
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_HYPERALISEQ and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_HYPERALISEQ.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_HYPERALISEQ – Sequelae of hyperalimentation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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