Acute appendicitis, with complications

APPENDACUT_COMPLIC

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K35.0, K35.1
  • Hospital discharge: ICD-9 540[0-1]
  • Hospital discharge: ICD-8 540
  • Hospital discharge: excluded ICD-8 54090|54099
  • Cause of death: ICD-10 K35.0, K35.1
  • Cause of death: ICD-9 540[0-1]
  • Cause of death: ICD-8 540
  • Cause of death: excluded ICD-8 54090|54099

2 out of 7 registries used, show all original rules.

10182

4. Check minimum number of events

None

10182

5. Include endpoints

None

10182

6. Filter based on genotype QC (FinnGen only)

9202

Control definitions (FinnGen only)

Control exclude
K11_APPENDIX

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 84045 36878 46560
Only index persons 72602 32822 39780
Unadjusted period prevalence (%)
Whole population 1.19 1.06 1.30
Only index persons 1.38 1.21 1.52
Median age at first event (years)
Whole population 33.29 33.34 32.99
Only index persons 30.31 30.74 29.95

-FinnGen-

Key figures

All Female Male
Number of individuals 9202 4464 4738
Unadjusted period prevalence (%) 1.89 1.58 2.17
Median age at first event (years) 34.37 31.67 36.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
9450
Matched controls
94497
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
6421
FHL
Appendicectomy
20.1
307.7
1329
762
K35.1
ICD-10 Finland
Acute appendicitis with peritoneal abscess
16384.0
307.7
1974
*
54001
ICD-8 Finland
Acute appendicitis, Cum peritonitide diffusa
+∞
307.7
463
*
5400B
ICD-9 Finland
Acute appendicitis, With generalised peritonitis[APPENDICITIS ACUTA CUM PERITONITIDE CIRCUMSCRIPTA]
+∞
307.7
515
*
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
621.6
307.7
1810
36
54003
ICD-8 Finland
Acute appendicitis, Cum abscessu
+∞
307.7
442
*
JEA01
NOMESCO Finland
Laparoscopic appendectomy
93.6
307.7
1687
219
K35.0
ICD-10 Finland
Acute appendicitis with generalized peritonitis
+∞
307.7
2341
*
54002
ICD-8 Finland
Acute appendicitis, Cum peritonitide circumscripta
+∞
307.7
352
*
5400A
ICD-9 Finland
Acute appendicitis, With generalised peritonitis[APPENDICITIS ACUTA CUM PERITONITIDE DIFFUSA]
+∞
307.7
330
*
54091
ICD-8 Finland
Acute appendicitis, Gangraenosa, peritonitide non indicata
+∞
307.7
2029
*
54000
ICD-8 Finland
Acute appendicitis, Perforans
+∞
307.7
665
*
5401A
ICD-9 Finland
Acute appendicitis, With peritoneal abscess
+∞
307.7
458
*
JEA00
NOMESCO Finland
Appendectomy
25.9
307.7
1884
901
ZXD05
NOMESCO Finland
Urgent procedure
2.2
260.6
3205
17884
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.9
226.4
1216
4609
P01AB01
ATC
metronidazole; oral, rectal
2.0
226.2
4102
26122
K37
ICD-10 Finland
Unspecified appendicitis
38.1
226.0
139
37
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
120.7
3395
23485
JN3AD
NOMESCO Finland
Abdominal CT examination
1.9
91.4
1293
7231
K35
ICD-10 Finland
Acute appendicitis
19.6
90.3
70
36
K36
ICD-10 Finland
Other appendicitis
436.8
87.2
87
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
84.0
2304
15535
JFB20
NOMESCO Finland
Ileocaecal resection
7.7
79.7
111
145
54099
ICD-8 Finland
Acute appendicitis, Without mention of peritonitis
+∞
74.0
71
*
R10.0
ICD-10 Finland
Acute abdomen
2.9
69.5
347
1246
D88
ICPC
Appendicitis
106.6
67.9
74
7
5409X
ICD-9 Finland
Acute appendicitis, Without mention of peritonitis
+∞
61.5
59
*
99850
ICD-8 Finland
Other complications of surgical procedures, Postoperative wound infection
7.1
61.2
92
131
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
60.5
1923
13276
JAH01
NOMESCO Finland
Laparoscopy
2.2
49.8
416
1903
C18.11
ICD-10 Finland
Malignant tumor of the appendix invasive carcinoma
9.7
44.7
52
54
JAH00
NOMESCO Finland
Laparotomy
2.5
41.0
259
1047
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
40.8
1119
7409
C18.19
ICD-10 Finland
Malignant tumor in appendix other or unspecified histology
10.9
37.3
40
37
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.0
35.9
376
1878
J01DB01
ATC
cefalexin; oral
1.4
35.9
7301
67198
54009, ,
ICD-8 Finland
+∞
30.2
29
*
J01MA12
ATC
levofloxacin; systemic
1.4
29.0
1462
10882
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
28.0
2777
22877
ZXK00
NOMESCO Finland
Conversion from percutaneous endoscopic to open procedure
3.7
25.6
82
226
JFB30
NOMESCO Finland
Right hemicolectomy
2.8
24.5
124
450
54200
ICD-8 Finland
Other appendicitis, Appendicitis chronica
+∞
22.9
22
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
22.0
822
5776
ZXE00
NOMESCO Finland
One hour or less
1.3
22.0
2940
24963
UJF32
NOMESCO Finland
Coloscopy
1.3
21.2
1984
16114
54208
ICD-8 Finland
Other appendicitis
+∞
20.8
20
*
JEA10
NOMESCO Finland
Appendectomy with drainage
57.6
19.9
23
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
1.8
19.4
316
1825
K65.0
ICD-10 Finland
Acute peritonitis
2.7
19.0
102
383
54199
ICD-8 Finland
Appendicitis, unqualified
+∞
18.8
18
*
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
2.7
18.7
99
369
N02BE01
ATC
paracetamol; systemic, rectal
1.3
17.8
7801
74353
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
5.4
17.6
34
63
J01MA02
ATC
ciprofloxacin; systemic
1.2
16.9
3047
26529
WX402
NOMESCO Finland
General anaesthesia
1.3
16.4
1707
13993
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
2.3
16.3
127
568
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
16.2
1663
13604
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
1.8
15.3
227
1277
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
2.1
14.2
127
601
JFK10
NOMESCO Finland
Freeing of adhesions in intestinal obstruction
4.2
14.1
37
89
JAK00
NOMESCO Finland
Laparotomy and drainage of peritoneal cavity
5.7
13.2
24
42
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.5
12.9
472
3300
J01DA01
ATC
[U] cefalexin
1.2
12.7
4949
45739
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.2
12.5
3700
33440
C18.1
ICD-10 Finland
Malignant neoplasm: Appendix
9.3
12.4
25
27
D01
ICPC
Abdominal pain/cramps general
1.3
12.1
816
6307
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
2.0
11.8
127
646
C18.10
ICD-10 Finland
Malignant tumor of the appendix without histology
5.4
11.3
22
41
B01AB05
ATC
enoxaparin; parenteral
1.2
11.3
2275
19858
JAD11
NOMESCO Finland
Laparoscopic repair of incisional hernia
2.2
11.0
87
394
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.2
11.0
1287
10654
K56.7
ICD-10 Finland
Ileus, unspecified
1.9
10.9
123
636
WX704
NOMESCO Finland
Intubation
1.4
10.6
570
4261
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
2.2
10.5
81
363
5420A
ICD-9 Finland
Other appendicitis[APPENDICITIS CHRONICA]
+∞
10.4
10
*
N70.0
ICD-10 Finland
Acute salpingitis and oophoritis
2.9
10.0
46
161
JAK03
NOMESCO Finland
Laparotomy and peritoneal irrigation
4.7
9.7
22
47
JAD10
NOMESCO Finland
Repair of incisional hernia
2.6
9.7
55
215
D12.1
ICD-10 Finland
Benign neoplasm: Appendix
3.7
9.4
29
79
5428X
ICD-9 Finland
Other appendicitis[APPENDICITIS ALIA DEFINITA]
+∞
9.4
9
*
54308
ICD-8 Finland
Other diseases of appendix, Alii definiti
+∞
9.4
9
*
5410X
ICD-9 Finland
Appendicitis, unqualified[APPENDICITIS NUD]
+∞
9.4
9
*
8140/3-C18.1
ICD-O-3
Adenocarcinoma, NOS, of appendix
21.7
9.3
13
6
56096
ICD-8 Finland
Intestinal obstruction without mention of hernia, Ileus propter adhaesionem (functione laesa circulationis intestinalis non indicata)
4.5
9.3
22
49
C18.09
ICD-10 Finland
Malignant tumor of caecum other or unspecified histology
4.0
9.2
25
62
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
3.1
9.2
37
120
C18.01
ICD-10 Finland
Malignant tumor of the caecum invasive carcinoma
2.4
9.2
60
251
WX110
NOMESCO Finland
Infiltration anesthesia
1.1
9.1
5864
55552
JEW96
NOMESCO Finland
Other operation on appendix
50.0
8.7
10
*
K56.0
ICD-10 Finland
Paralytic ileus
2.3
8.6
64
283
Z3226
NOMESCO Finland
Physiotherapist
1.2
8.6
1216
10247
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
2.1
8.4
79
384
54090
ICD-8 Finland
Acute appendicitis, Phlegmonosa, peritonitide non indicata
+∞
8.3
8
*
A41.9
ICD-10 Finland
Sepsis, unspecified
1.5
8.1
224
1487
56709
ICD-8 Finland
Peritonitis, Unspecified
33.4
8.1
10
*
6429
FHL
Other measure in this category
22.0
8.0
11
5
6101
FHL
Exploratory laparotomy, includes possible biopases
3.2
7.9
30
94
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
2.9
7.8
34
116
8240/3-C18.1
ICD-O-3
Neuroendocrine tumor, NOS, of appendix
9.4
7.8
15
16
I50
ICD-10 Finland
Heart failure
1.6
7.7
170
1071
61602
ICD-8 Finland
Diseases of parametrium and pelvic peritoneum (female), Abscessus fossae Douglasi
15.0
7.7
12
8
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.2
7.5
1230
10514
K38.8
ICD-10 Finland
Other specified diseases of appendix
80.2
7.4
8
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
1.7
7.4
116
670
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
1.8
7.3
104
584
54093, ,
ICD-8 Finland
+∞
7.3
7
*
8240/3-C18.2
ICD-O-3
Neuroendocrine tumor, NOS, of ascending colon
9.3
7.3
14
15
6561
FHL
Removal of fasteners and related measures
3.9
7.1
20
51
9985A
ICD-9 Finland
Other complications of procedures, not elsewhere classified, Postoperative infection
2.4
7.1
46
192
5608A
ICD-9 Finland
Intestinal obstruction without mention of hernia, Other specified intestinal obstruction[OBSTRUCTIO INTESTINALIS ,ADHESIONES INTRAABDOMINALE]
3.3
7.1
25
75
E9499
ICD-8 Finland
Late effect of other surgical and medical procedures
4.2
7.0
18
43
JWA00
NOMESCO Finland
Repair of wound dehiscence in gastroenterological surgery
2.5
7.0
41
164
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.2
6.9
1326
11481
D06
ICPC
Abdominal pain localized other
1.3
6.9
563
4467
55121
ICD-8 Finland
Other hernia of abdominal cavity without mention of obstruction, Alia hernia ventralis (incisionalis, in cicactrice)
3.7
6.9
21
57
M01AE03
ATC
ketoprofen; systemic, rectal
1.1
6.8
2654
24187
6565
FHL
Sewerage the other way
40.0
6.8
8
*
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
3.6
6.7
21
58
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
2.0
6.7
66
328
JFB00
NOMESCO Finland
Partial resection of small intestine
1.8
6.7
100
570
N05AH02
ATC
clozapine; systemic
1.7
6.6
114
676
JAK04
NOMESCO Finland
Laparoscopy and peritoneal irrigation
7.8
6.6
14
18
SPAT1153
SPAT
Removal of sutures
1.1
6.6
2153
19398
K50.0
ICD-10 Finland
Crohn disease of small intestine
1.7
6.4
98
563
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
1.3
6.4
394
3014
J01FF01
ATC
clindamycin; systemic
1.1
6.4
1932
17309
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.2
6.3
1160
10004
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
2.2
6.3
48
216
C18.12
ICD-10 Finland
Malignant tumor of the appendix carcinoma of the adenoma
11.0
6.3
11
10
K35.2
ICD-10 Finland
Acute appendicitis with generalized peritonitis
+∞
6.2
6
*
5609X
ICD-9 Finland
Intestinal obstruction without mention of hernia, Unspecified intestinal obstruction
3.7
6.2
19
52
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.2
6.1
1085
9334
XX4AT
NOMESCO Finland
Other canalization with ultrasound guidance
2.4
6.0
37
152

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1748
10578
1.80
96.47
1.3
1.3
—
—
—
0
0
2976
22857
1.44
54.50
4.6
4.5
—
—
—
0
0
1742
12020
1.55
54.21
2.0
2.1
—
—
—
0
0
3263
26452
1.36
40.20
2.7
2.5
—
—
—
0
0
3183
26243
1.32
33.24
2.8
2.8
57.29
63.35
u/l
1.53
2980
24441
4916
43308
1.28
29.86
6.8
6.9
11.83
11.67
umol/l
0.36
4727
41390
4332
38165
1.25
24.02
3.0
2.8
—
—
estimate
—
0
0
2446
20188
1.29
23.43
2.6
2.4
—
—
—
0
0
1483
11660
1.32
20.01
8.3
7.8
104.31
104.40
mmol/l
0.28
1483
11654
4258
38006
1.22
19.12
14.6
14.9
1.24
1.25
inr
1.43
3562
31730
5617
51883
1.20
16.51
4.6
4.5
388.33
1645.43
e6/l
3.77
103
725
5240
48367
1.19
14.56
5.8
5.3
6.76
6.72
mmol/l
0.61
4996
45958
6620
62553
1.19
13.41
8.9
8.6
78.68
79.01
u/l
0.21
6330
59676
5098
47149
1.18
13.20
11.0
10.1
4.48
4.10
e9/l
16.51
4440
40941
1025
8115
1.30
12.78
2.7
2.6
36.96
47.35
u/l
0.90
888
6909
3460
31069
1.18
12.67
3.8
3.8
40.96
76.03
ng/l
1.40
2444
21354
3034
26944
1.19
12.67
3.6
3.5
70.53
77.17
e6/l
0.08
2354
20630
2154
18589
1.21
12.31
2.9
2.8
6.41
5.03
e6/l
3.05
1965
16988
883
6935
1.30
11.67
3.2
3.4
4.61
4.59
kpa
0.06
855
6749
1038
8418
1.26
10.60
4.0
4.1
5.81
5.81
kpa
0.06
1007
8211
1005
8201
1.25
9.70
4.0
4.1
1.61
1.80
mmol/l
0.84
878
7180
4023
37099
1.15
9.43
5.6
5.3
35.21
35.75
g/l
7.00
3769
34941
2407
21394
1.17
9.34
4.6
4.3
88.65
89.51
%
0.98
2356
20927
3359
30612
1.15
9.29
4.3
4.0
77.80
86.73
e6/l
0.39
2454
21776
5802
54897
1.15
9.25
4.6
4.5
1.34
2.55
—
6
83
1041
8584
1.24
9.14
4.0
4.1
7.38
7.38
ph
0.74
571
4974
2586
23209
1.16
8.72
3.6
3.4
0.53
0.42
e6/l
0.66
1931
17006
1182
9982
1.21
8.19
2.6
2.9
9.13
8.63
umol/l
0.25
1032
8792
929
7674
1.23
8.00
9.3
8.4
1.31
1.34
mmol/l
0.32
914
7515
895
7372
1.24
7.92
10.8
9.8
—
—
—
0
0
2451
22060
1.15
7.79
3.4
3.3
0.00
163.67
estimate
—
5
95
3928
36471
1.13
7.77
7.8
6.9
1.21
1.21
mmol/l
0.11
3670
33925
4638
43571
1.13
7.45
3.9
3.9
0.03
0.17
estimate
0.62
919
8373
3736
34643
1.13
7.44
3.4
3.4
6.17
6.19
ph
0.52
2112
19696
8115
79107
1.18
7.25
18.4
16.3
33.35
24.13
mg/l
65.17
6999
65373
4606
43318
1.12
7.13
3.9
3.8
5.79
4.16
estimate
0.23
965
8942
1777
15724
1.16
7.05
3.2
3.0
535.78
537.75
mosm/kgh2o
0.13
1555
13855
1291
11142
1.18
7.00
6.8
6.5
1.03
1.04
mmol/l
0.71
1203
10451
4557
42881
1.12
6.89
3.9
3.8
0.00
0.00
estimate
0.69
962
8778
4340
40852
1.12
6.30
8.5
7.6
1.21
1.21
mmol/l
0.70
3759
35485
670
5494
1.24
6.21
12.0
10.6
0.65
0.63
%
0.26
665
5459
5917
56709
1.12
6.06
3.5
3.4
49.96
49.06
u/l
0.30
5645
53633
634
5194
1.24
5.93
3.1
3.5
129.50
129.89
g/l
0.17
611
5059
687
5681
1.23
5.89
11.8
10.3
1.33
1.33
%
0.02
681
5648
548
4424
1.25
5.86
2.8
3.2
1.29
1.27
%
0.16
548
4400
541
4362
1.25
5.85
2.7
3.1
0.62
0.62
%
0.26
541
4344
972
8339
1.18
5.63
10.0
9.1
122.11
121.95
g/l
0.09
956
8157
216
1535
1.42
5.63
1.6
1.9
—
—
—
0
0
2559
23523
1.12
5.50
3.4
3.2
0.01
0.12
estimate
1.42
749
7001
1032
8925
1.18
5.44
9.4
8.6
95.49
95.60
%
0.24
1005
8637
161
1101
1.47
5.19
1.4
1.3
—
—
—
0
0
3491
32729
1.11
5.12
3.8
3.7
0.02
0.20
estimate
1.20
782
7273
978
8489
1.17
4.93
4.6
4.4
16.48
29.18
ug/l
1.22
799
6922
663
5575
1.20
4.83
4.2
3.6
5.14
5.14
kpa
0.09
636
5328
596
4962
1.21
4.82
4.2
4.2
24.22
24.20
mmol/l
0.06
583
4908
304
2356
1.30
4.60
2.1
2.3
6684.31
5395.86
u/l
0.19
109
936
2531
23449
1.11
4.58
4.0
4.0
0.00
0.00
estimate
3.39
865
8065
640
5396
1.20
4.55
4.2
3.6
7.42
7.42
ph
0.04
546
4512
4120
39093
1.10
4.53
7.4
6.8
8.79
8.89
%
1.43
3900
36799
8211
80603
1.14
4.51
21.2
18.9
139.63
139.71
mmol/l
2.18
8100
79135
2589
24061
1.10
4.37
3.3
3.2
1341.33
1373.70
ng/l
0.17
2243
20759
448
3662
1.23
4.36
1.7
1.6
13.22
14.88
iu/ml
0.09
13
100
1131
10023
1.15
4.31
9.1
8.2
12.07
12.49
kpa
1.96
1098
9666
1484
13387
1.13
4.30
3.3
3.2
3.05
2.29
e6/l
1.68
689
6543
1131
10029
1.15
4.27
9.2
8.2
5.09
5.09
kpa
0.07
1100
9669
4105
39024
1.09
4.23
7.3
6.7
2.78
2.86
%
1.38
3886
36707
29
127
2.29
4.18
1.3
1.3
—
—
—
0
0
388
3138
1.25
4.18
1.2
1.3
—
—
—
0
0
4100
39003
1.09
4.13
7.4
6.8
0.67
0.68
%
1.15
3880
36648
899
7865
1.16
4.11
8.4
8.0
10.24
9.93
mmol/l
0.66
866
7561
8224
80828
1.13
4.07
21.4
19.1
3.97
3.98
mmol/l
1.78
8101
79216
1124
10010
1.14
3.99
9.2
8.2
7.42
7.42
ph
0.49
573
5483
1606
14629
1.12
3.93
3.2
3.0
1.08
1.07
e6/l
0.02
818
7811
1116
9944
1.14
3.93
9.2
8.1
0.82
0.90
mmol/l
0.26
934
8178
1598
14554
1.12
3.92
2.8
2.7
12.86
13.24
umol/l
1.30
1505
13640
223
1698
1.32
3.90
4.0
4.2
2.81
2.52
mmol/l
0.96
149
1139
1388
12575
1.12
3.73
2.8
2.7
22.13
23.04
%
1.80
1303
11753
3003
28281
1.09
3.71
7.2
6.6
—
4.00
—
0
5
3867
36823
1.08
3.66
2.5
2.5
76.95
76.74
nmol/l
0.17
3536
33689
244
1899
1.29
3.66
4.6
3.9
—
—
—
0
0
4113
39294
1.08
3.56
7.1
6.6
57.96
57.37
%
2.46
3945
37638
928
8227
1.14
3.54
2.3
2.3
0.21
0.21
g/l
0.02
855
7685
275
2185
1.27
3.51
2.9
3.5
62.66
62.47
%
0.05
261
2119
3465
32890
1.08
3.51
2.2
2.1
—
—
—
0
0
1111
9986
1.13
3.42
1.8
1.8
—
—
—
0
0
4440
42594
1.08
3.41
7.0
6.5
0.04
0.04
e9/l
0.99
3836
36700
1490
13628
1.11
3.37
2.8
2.7
2.34
2.31
g/l
1.10
1400
12661
4181
40031
1.08
3.36
7.3
6.7
27.20
27.62
%
1.66
3999
38043
586
5045
1.17
3.34
11.6
10.7
16.02
16.09
%
0.28
573
4879
4424
42467
1.08
3.30
7.0
6.5
0.59
0.59
e9/l
0.61
3830
36601
4563
43875
1.08
3.23
7.4
6.8
0.19
0.19
e9/l
1.33
4004
38447
1990
18505
1.10
3.21
1.9
1.8
1.46
1.22
mg/l
1.64
1558
14493
1556
14305
1.10
3.18
3.6
3.6
0.82
0.82
mmol/l
0.07
1464
13545
2637
24835
1.09
3.17
7.2
6.6
—
—
—
0
0
439
3707
1.19
3.16
3.5
3.6
25.04
25.17
mmol/l
0.31
423
3578
354
2930
1.22
3.15
4.4
3.7
24.85
24.80
mmol/l
0.10
324
2671
132
962
1.38
3.15
3.3
3.4
3.15
12.38
nmol/l
0.95
125
931
791
6999
1.14
3.13
2.5
2.5
0.50
0.41
e6/l
0.62
746
6707
38
208
1.83
3.11
1.6
1.8
—
—
—
0
0
295
2401
1.24
3.10
1.5
1.5
5.64
13.25
iu/ml
—
9
49
130
949
1.37
3.08
1.8
1.8
90.26
89.63
%
0.65
130
934
3805
36388
1.08
3.07
13.3
11.7
0.00
0.00
e9/l
0.80
3091
29606
142
1057
1.35
2.99
2.6
2.4
1.12
1.26
g/24h
0.31
86
636
6178
60167
1.08
2.98
4.5
4.4
12.20
11.77
mm/h
1.46
5793
56672
441
3749
1.18
2.97
4.3
3.7
—
—
—
0
0
189
1468
1.29
2.96
1.9
2.0
5.11
5.09
mmol/24h
0.03
176
1309
369
3089
1.20
2.95
3.7
3.7
4849.00
1991.84
u/ml
0.43
325
2690
4509
43432
1.07
2.94
7.1
6.6
1.88
1.90
e9/l
0.36
3987
38334
236
1889
1.26
2.90
2.5
2.4
109.59
115.49
ug/min
0.07
145
1154
255
2064
1.24
2.85
3.9
3.1
8.05
8.15
kpa
0.50
250
2017
696
6153
1.14
2.81
4.5
4.2
93.55
92.84
ng/l
0.07
608
5369
63
408
1.55
2.80
1.2
1.3
244.01
414.74
u/l
1.44
58
376
839
7517
1.13
2.76
4.5
4.4
7.36
7.36
ph
0.08
612
5458
13
48
2.71
2.71
1.2
1.0
—
—
—
0
0
2593
24544
1.08
2.69
4.9
4.4
7.40
7.40
ph
0.08
1829
17565
596
5233
1.15
2.68
12.4
10.3
24.18
24.25
mmol/l
0.19
585
5135
1457
13469
1.10
2.66
1.8
1.7
1180.99
1153.36
nmol/l
0.51
1124
10337
2025
18991
1.08
2.65
4.1
4.0
1.02
1.10
kg/l
0.50
1329
12663
452
3891
1.17
2.65
4.5
4.6
36.90
36.91
°c
0.32
442
3856
641
5684
1.14
2.51
2.5
2.4
—
—
—
0
0
1042
9512
1.11
2.47
4.8
4.8
31.81
32.05
%
0.30
721
6517
717
6414
1.13
2.44
1.2
1.2
—
—
—
0
0
328
2770
1.19
2.44
3.6
3.4
277.22
408.01
mg/l
1.87
158
1306
19
89
2.14
2.44
1.7
2.0
—
—
—
0
0
17
76
2.24
2.43
2.1
2.5
—
—
—
0
0
197
1584
1.25
2.39
1.2
1.2
132.22
346.46
titre
2.31
18
113
218
1773
1.23
2.39
4.0
3.7
481.53
670.52
u/ml
0.34
202
1615
293
2459
1.20
2.35
8.0
10.0
—
—
—
0
0
319
2699
1.19
2.34
3.9
3.9
1.35
1.40
mmol/l
0.32
311
2650
1065
9766
1.10
2.32
1.4
1.4
—
—
—
0
0
303
2556
1.19
2.30
2.9
2.7
3.74
3.60
g/l
0.82
286
2439
142
1103
1.29
2.30
1.6
1.9
—
—
—
0
0
1124
10340
1.10
2.29
1.5
1.5
—
—
—
0
0
156
1228
1.27
2.28
6.7
5.4
361.98
362.55
umol/l
0.02
136
1067
2703
25757
1.07
2.27
2.2
2.3
273.75
214.06
u/l
0.80
2575
24428
1151
10607
1.10
2.26
2.5
2.5
113.50
136.36
ug/g
2.07
928
8547
3010
28795
1.07
2.24
3.4
3.4
31.35
34.90
u/l
2.98
2850
27246
175
1401
1.25
2.23
3.4
3.6
1.88
1.65
%
0.31
159
1258
8520
84339
1.10
2.17
23.1
20.8
79.15
78.64
umol/l
0.64
8443
83410
454
3977
1.15
2.17
1.1
1.1
1.00
14.85
u/ml
—
9
44
235
1951
1.21
2.15
3.0
3.2
1.59
1.61
mmol/l
0.08
228
1895
1400
13047
1.09
2.14
2.3
2.2
29.76
29.69
s
0.16
1361
12700
395
3432
1.16
2.12
2.4
1.9
2.41
2.16
ug/l
0.21
359
3050
780
7078
1.11
2.10
2.7
2.6
66.25
66.49
g/l
0.40
709
6548
2922
27979
1.06
2.09
3.6
3.6
2.35
2.35
mmol/l
0.14
2642
25597
329
2822
1.17
2.09
3.5
3.4
48.21
73.34
mg/l
0.67
275
2396
1948
18411
1.07
2.06
1.3
1.3
2.01
1.83
u/ml
0.20
523
5150
2469
23524
1.07
2.06
3.0
2.9
0.13
0.05
0.59
45
504
174
1409
1.24
2.04
1.7
1.4
5.86
9.63
u/ml
—
5
28
328
2820
1.17
2.03
3.5
3.4
31.43
50.76
mg/l
2.70
275
2397
57
391
1.46
2.03
1.1
1.3
173.61
170.34
mmol/24h
0.09
57
391
89
662
1.35
2.00
1.2
1.2
—
—
—
0
0
216
1796
1.21
1.97
3.9
3.0
89.57
89.96
%
0.32
211
1751
353
3061
1.16
1.97
2.5
2.3
453.16
603.36
ug/l
0.78
332
2900
8462
83797
1.09
1.94
12.9
12.3
27.06
27.19
u/l
0.26
8276
81611
370
3228
1.15
1.91
2.3
2.1
21.29
21.00
s
0.28
335
2855
99
758
1.31
1.85
1.5
1.4
132816.06
119564.38
e6/l
0.07
65
501
2260
21556
1.06
1.81
2.4
2.4
2.87
2.80
mg/l
0.70
1981
18725
2384
22780
1.06
1.80
2.8
2.8
347.73
344.36
umol/l
0.89
2105
20312
15
73
2.06
1.80
2.6
2.4
0.27
0.51
u/field
0.88
15
73
431
3821
1.13
1.78
4.6
5.2
1.61
1.65
%
0.36
408
3626
581
5247
1.11
1.76
7.0
7.0
24.43
24.43
mmol/l
0.00
564
5030
3717
36012
1.05
1.70
2.1
2.1
95.24
95.49
pmol/l
0.12
2057
19542
17
89
1.91
1.69
1.6
1.3
18.84
26.36
%
0.36
11
67
37
243
1.52
1.67
5.4
3.5
57.15
53.45
%
0.50
37
232
606
5506
1.11
1.65
1.2
1.2
125.98
142.61
u/ml
0.53
250
2106
437
3899
1.13
1.65
1.9
1.8
1.58
1.54
g/l
0.35
382
3360
6746
66394
1.06
1.64
22.3
19.8
13.65
13.62
%
1.10
6662
65550
805
7424
1.09
1.62
2.9
2.6
70.49
69.71
e9/l
0.23
587
5458
1035
9650
1.08
1.60
3.1
2.6
1.80
1.79
%
0.08
925
8624
262
2267
1.16
1.57
3.4
3.2
2.07
1.93
index
0.15
118
1196
46
321
1.44
1.56
2.0
2.0
40.41
40.27
g/l
0.05
46
321
82
629
1.31
1.56
1.6
1.6
2010.51
1985.06
ml
0.08
82
620
39
264
1.48
1.55
1.1
1.1
—
—
—
0
0
1726
16408
1.06
1.54
1.6
1.5
2.42
2.47
g/l
0.58
1073
10459
5
15
3.33
1.52
1.0
1.1
317.60
265.07
u/ml
—
5
15
202
1718
1.18
1.51
3.0
1.9
0.85
0.87
nmol/l
0.12
166
1471
106
845
1.26
1.51
1.5
1.4
6.60
6.26
mmol/l
0.51
99
788
1524
14446
1.07
1.49
1.9
1.9
—
—
—
0
0
1981
18928
1.06
1.49
4.8
4.8
—
—
—
0
0
101
803
1.26
1.48
1.1
1.2
—
—
—
0
0
327
2890
1.14
1.47
2.6
2.1
—
—
—
0
0
346
3070
1.13
1.46
2.5
2.0
—
—
—
0
0
348
3089
1.13
1.46
2.6
2.1
—
—
—
0
0
351
3118
1.13
1.46
2.6
2.1
—
—
—
0
0
2862
27642
1.05
1.44
4.5
4.2
9.60
8.51
mg/mmol
0.70
1872
17614
63
472
1.34
1.44
1.7
2.0
8.89
8.05
mmol/l
0.91
63
472
5
16
3.13
1.44
1.0
2.6
—
—
—
0
0
124
1013
1.23
1.43
1.2
1.3
0.33
0.19
nmol/l
0.43
92
790
684
6304
1.09
1.42
4.2
3.9
—
—
—
0
0
391
3503
1.12
1.42
1.9
1.8
10.20
7.19
iu/ml
0.71
88
840
141
1170
1.21
1.41
1.1
1.3
0.61
3.26
nmol/l
0.85
130
1134
349
3108
1.13
1.40
2.6
2.0
—
—
—
0
0
1300
12287
1.07
1.40
1.7
1.7
—
—
—
0
0
10
46
2.18
1.39
1.0
1.0
—
—
—
0
0
22
134
1.64
1.38
1.4
1.6
132.46
120.24
ug/l
0.16
17
117
133
1100
1.21
1.38
2.5
2.8
—
—
—
0
0
288
2538
1.14
1.37
3.6
3.2
1.92
2.90
ratio
1.11
170
1460
24
150
1.60
1.37
3.5
2.0
6.93
7.69
mmol/l
0.64
12
87
83
653
1.27
1.35
1.3
1.4
—
—
—
0
0
291
2570
1.14
1.35
1.5
1.4
296.80
272.94
ug/g
0.95
162
1526
2994
28992
1.05
1.34
3.8
3.5
7.75
7.81
mmol/l
0.29
2582
24678
8681
86227
1.08
1.34
27.4
24.4
91.15
91.13
fl
0.14
8618
85389
172
1461
1.18
1.34
3.7
3.2
0.83
0.82
nmol/l
0.15
141
1147
8682
86238
1.08
1.34
27.5
24.5
4.49
4.52
e12/l
6.87
8500
84374
0
38
0.00
1.34
0.0
1.0
—
—
—
0
0
0
38
0.00
1.34
0.0
1.0
—
—
—
0
0
0
38
0.00
1.34
0.0
1.0
—
—
—
0
0
0
38
0.00
1.34
0.0
1.0
—
—
—
0
0
0
39
0.00
1.33
0.0
1.0
—
—
—
0
0
739
6857
1.08
1.33
2.2
2.4
7.00
7.71
ug/l
0.56
655
6064
8683
86254
1.08
1.32
27.6
24.7
135.18
136.24
g/l
9.05
8618
85433
8680
86226
1.08
1.31
27.4
24.4
30.37
30.37
pg
0.00
8617
85390
8682
86248
1.08
1.31
27.5
24.6
6.87
6.71
e9/l
6.99
8501
84370
61
463
1.32
1.30
3.6
3.5
27.17
27.10
mu/l
0.00
54
437
2808
27170
1.05
1.30
3.8
3.5
53.66
48.27
mg/l
0.69
1861
17691
8677
86202
1.08
1.29
27.5
24.5
250.53
250.22
e9/l
0.17
8527
84594
58
438
1.33
1.28
1.7
1.6
—
—
—
0
0
8680
86234
1.08
1.28
28.1
25.0
41.33
41.19
%
0.07
8611
85353
5
18
2.78
1.28
1.0
1.2
28.35
37.55
umol/24h
—
5
18
48
352
1.37
1.28
1.8
1.7
—
—
—
0
0
52
387
1.35
1.27
2.0
1.7
1.97
3.11
u/field
0.78
38
275
106
867
1.23
1.25
2.1
2.4
1.20
1.20
mmol/l
0.01
106
855
2382
22980
1.05
1.24
1.7
1.7
19.71
19.90
nmol/l
0.26
2048
19731
7613
75344
1.05
1.24
6.5
6.3
39.51
39.27
mmol/mol
1.51
7168
71050
1261
11959
1.06
1.24
1.4
1.4
564.13
495.39
titre
0.57
271
2500
487
4456
1.10
1.22
1.2
1.3
—
—
—
0
0
25
163
1.54
1.22
1.1
1.1
—
—
—
0
0
10
49
2.04
1.21
1.0
1.1
—
33.63
—
0
19
42
305
1.38
1.20
5.2
5.0
—
—
—
0
0
37
513
0.72
1.20
1.3
1.5
1.16
1.23
nmol/l
0.18
30
377
63
487
1.30
1.20
12.1
14.0
0.62
0.62
mmol/l
0.01
56
445
281
3153
0.89
1.19
1.6
1.6
13.54
16.43
u/ml
0.54
69
796
143
1211
1.18
1.19
1.2
1.3
0.21
0.24
nmol/l
—
8
77
365
3299
1.11
1.18
2.5
2.4
2.90
2.88
g/l
0.11
330
3034
1681
16099
1.05
1.18
4.0
3.9
369.42
498.43
ng/l
0.81
1288
12501
188
1630
1.16
1.17
3.8
3.5
30.95
26.68
mg/l
0.83
129
1125
775
7249
1.08
1.16
4.2
4.4
0.82
0.71
%
0.54
273
2245
238
2100
1.14
1.16
3.5
2.9
—
—
—
0
0
99
812
1.22
1.16
4.2
4.0
—
—
—
0
0
13
72
1.81
1.14
1.1
1.2
64.62
68.89
ug/l
0.10
13
72
107
886
1.21
1.14
2.1
2.3
4.05
4.08
mmol/l
0.38
107
874
107
886
1.21
1.14
2.1
2.3
105.01
105.40
mmol/l
0.34
107
874
1021
9650
1.07
1.13
1.7
1.7
—
—
—
0
0
22
331
0.66
1.12
2.2
2.2
464.07
3123.97
e6/l
0.58
15
228
90
734
1.23
1.12
1.6
1.6
30.63
29.78
%
0.09
58
439
39
284
1.37
1.12
1.4
1.4
562.06
361.78
nmol/24h
0.16
39
284
43
319
1.35
1.10
1.0
1.1
19.15
4.26
u/ml
—
9
49
144
1231
1.17
1.09
2.2
2.1
0.84
0.90
%
0.71
99
846
709
6629
1.08
1.09
3.1
2.8
10.26
10.64
g/l
1.72
642
6145
384
3499
1.10
1.08
4.9
5.5
0.84
0.88
%
1.18
365
3315
120
1419
0.84
1.08
1.2
1.2
—
—
—
0
0
119
1002
1.19
1.08
1.8
2.2
-0.06
0.46
mmol/l
0.87
113
961
51
390
1.31
1.08
1.1
1.1
167.69
183.88
iu/ml
0.26
51
390
2036
19651
1.05
1.05
3.7
3.7
0.45
0.43
0.02
20
192
186
1628
1.15
1.05
3.2
3.3
7.71
7.58
mmol/l
0.18
180
1584
809
7614
1.07
1.04
4.5
4.6
0.93
0.95
%
0.06
280
2365
11
60
1.83
1.02
1.1
1.2
—
—
—
0
0
70
866
0.81
1.02
2.7
2.7
—
—
—
0
0
40
298
1.34
1.02
1.8
1.4
64.69
64.62
%
0.00
29
251
3969
38854
1.04
1.01
3.3
3.1
139.29
133.42
ug/l
0.70
3741
36500
268
2412
1.11
0.98
1.3
1.3
4.63
4.50
u/ml
0.02
26
224
49
379
1.29
0.97
1.4
1.7
27.70
28.82
umol/l
0.41
44
356
21
140
1.50
0.97
1.1
1.1
—
45.27
—
0
6
7585
75184
1.04
0.96
4.3
4.3
1.35
1.31
mmol/l
4.88
7053
70006
431
3977
1.09
0.95
2.2
2.2
0.03
0.02
estimate
0.20
128
1269
144
1248
1.16
0.95
1.5
1.5
41.00
63.32
mu/l
2.01
133
1122
86
713
1.21
0.95
1.2
1.2
—
—
—
0
0
681
6398
1.07
0.94
4.5
4.1
1.23
1.23
mmol/l
0.07
609
5559
110
934
1.18
0.94
9.2
12.5
7.25
7.41
mmol/l
0.20
83
796
216
1926
1.12
0.94
1.2
1.3
58.53
41.75
u/ml
0.52
22
180
195
1728
1.13
0.94
1.7
1.6
—
—
—
0
0
10
55
1.82
0.92
1.8
1.6
368.70
320.29
umol/24h
—
10
55
150
1309
1.15
0.91
3.8
2.8
—
—
—
0
0
301
2740
1.10
0.91
1.7
1.7
284.53
289.82
mu/l
0.14
278
2516
202
1799
1.13
0.91
1.5
1.5
—
—
—
0
0
14
86
1.63
0.90
2.9
1.3
342.22
526.17
mg/24h
—
5
11
75
618
1.22
0.89
2.5
2.3
646.98
657.38
ml
0.08
50
421
132
1146
1.15
0.87
1.3
1.3
279.96
404.53
pmol/l
0.76
114
968
284
2585
1.10
0.87
1.3
1.3
31.61
35.72
u/ml
0.09
18
142
70
575
1.22
0.87
2.3
2.7
0.59
0.68
e9/l
0.73
65
553
767
7262
1.06
0.86
4.6
4.7
0.10
0.11
%
0.15
239
2017
12
72
1.67
0.85
1.1
1.3
143.83
105.97
ug/l
—
6
39
183
1629
1.13
0.84
1.5
1.5
141.63
152.73
au/ml
0.57
50
466
114
982
1.16
0.84
1.7
1.6
59.05
58.33
%
0.07
74
615
687
6487
1.06
0.84
1.5
1.5
—
—
—
0
0
13
80
1.63
0.84
3.8
1.5
—
—
—
0
0
75
624
1.20
0.83
1.2
1.2
—
—
—
0
0
104
891
1.17
0.83
1.6
1.5
—
—
—
0
0
33
248
1.33
0.83
1.3
1.2
41.04
39.49
g/l
0.23
14
125
265
2412
1.10
0.82
1.3
1.3
2.71
6.71
u/ml
3.02
37
364
281
2567
1.10
0.81
1.3
1.3
—
—
—
0
0
44
346
1.27
0.81
2.9
3.0
—
—
—
0
0
44
555
0.79
0.81
1.0
1.1
—
—
—
0
0
2416
23531
1.04
0.80
1.4
1.4
—
—
—
0
0
775
7358
1.06
0.80
4.8
4.8
0.68
0.30
%
0.43
234
1932
29
215
1.35
0.80
1.4
1.5
—
—
—
0
0
265
2417
1.10
0.80
2.6
2.1
—
—
—
0
0
139
1222
1.14
0.79
5.8
6.6
11.26
11.72
mg/l
0.57
133
1138
72
600
1.20
0.79
1.1
1.1
28.26
18.42
u/ml
0.80
31
253
31
233
1.33
0.79
1.0
1.0
5.67
9.73
u/ml
0.45
20
159
71
592
1.20
0.78
1.8
1.9
2.77
1.43
u/field
1.12
39
316
33
251
1.32
0.78
1.9
1.5
1.99
2.79
%
0.32
26
217
820
7806
1.06
0.78
2.1
2.1
0.00
0.02
estimate
2.87
174
1635
49
393
1.25
0.77
1.4
1.7
2.32
1.92
umol/l
1.26
42
361
20
281
0.71
0.77
2.1
2.0
—
—
—
0
0
20
281
0.71
0.77
2.3
2.0
2347.83
13728.58
e6/l
0.90
12
144
103
888
1.16
0.77
1.9
1.5
—
—
—
0
0
378
3508
1.08
0.77
2.4
2.3
4.23
4.22
g/l
0.08
343
3245
266
2906
0.91
0.77
1.1
1.1
—
—
—
0
0
0
28
0.00
0.76
0.0
4.3
—
3.84
—
0
19
134
1180
1.14
0.76
1.7
1.5
32.83
32.86
g/l
0.01
127
1071
378
3512
1.08
0.76
2.4
2.3
7.40
7.33
g/l
0.32
342
3244
67
558
1.20
0.75
2.1
2.5
519.18
498.64
e6/l
0.09
51
454
156
1389
1.13
0.75
1.1
1.1
104.67
8109.75
iu/ml
0.54
24
294
243
2217
1.10
0.74
2.0
2.0
3.85
9.63
iu/l
0.78
98
933
1746
16932
1.04
0.74
1.7
1.7
23417724.02
30713764.13
pmol/l
0.28
1469
14313
21
289
0.73
0.73
1.4
1.7
0.14
0.04
estimate
0.31
21
289
19
133
1.43
0.73
2.1
1.5
9.44
9.96
%
—
9
72
271
2489
1.09
0.72
1.3
1.4
9.51
9.99
u/l
0.22
213
2015
50
406
1.23
0.72
2.3
2.2
2580.16
2025.09
ml
1.27
44
364
123
1082
1.14
0.72
1.5
1.5
—
—
—
0
0
123
1082
1.14
0.72
1.5
1.5
—
—
—
0
0
123
1082
1.14
0.72
1.5
1.5
—
—
—
0
0
123
1082
1.14
0.72
1.5
1.5
—
—
—
0
0
53
434
1.22
0.71
2.3
2.3
490.46
493.54
min
0.08
39
331
376
3504
1.08
0.71
2.4
2.3
3.68
3.73
g/l
0.32
340
3239
93
803
1.16
0.70
2.1
2.4
1107.24
1179.73
e6/l
0.28
79
706
13
194
0.67
0.70
1.1
1.1
—
—
—
0
0
89
766
1.16
0.70
3.8
3.5
13.58
13.15
index
0.12
45
456
52
426
1.22
0.70
40.8
39.6
7.33
7.32
ug/l
0.01
46
388
266
2448
1.09
0.69
2.0
2.0
205.30
204.99
pmol/l
0.02
256
2329
6235
61728
1.03
0.69
4.5
4.3
14.73
14.71
pmol/l
0.24
5760
57165
408
3820
1.07
0.68
1.8
1.8
0.27
0.32
mg/l
1.27
194
1906
55
455
1.21
0.68
1.5
1.3
7.40
7.40
ph
0.05
40
311
11
69
1.59
0.68
1.5
1.0
20.33
16.76
iu/ml
—
6
25
11
69
1.59
0.68
1.1
1.2
—
—
—
0
0
682
7161
0.95
0.67
1.7
1.7
3.46
3.50
mmol/l
0.49
469
4944
227
2078
1.09
0.67
2.9
2.3
130.29
130.09
g/l
0.04
179
1594
108
948
1.14
0.67
2.3
2.3
—
—
—
0
0
20
272
0.73
0.66
1.2
1.2
—
24.59
%
—
0
32
241
2214
1.09
0.66
1.1
1.1
—
—
—
0
0
39
484
0.80
0.66
1.0
1.0
0.62
1.36
u/ml
0.74
16
105
288
2668
1.08
0.65
3.8
3.0
1.79
1.54
mg/l
3.89
262
2461
251
2314
1.09
0.64
1.5
1.4
—
—
—
0
0
135
1206
1.12
0.64
3.0
2.8
134.90
1294.66
u/ml
0.85
135
1192
5
29
1.72
0.64
1.0
1.1
—
—
—
0
0
234
2153
1.09
0.63
1.1
1.2
—
—
—
0
0
614
5843
1.05
0.63
2.4
2.4
18.27
21.89
au/ml
0.59
73
666
17
121
1.41
0.62
1.1
1.0
63.79
7.00
u/ml
0.61
17
121
8
49
1.63
0.62
4.8
3.1
—
—
—
0
0
10
63
1.59
0.61
1.0
1.1
—
—
—
0
0
182
1658
1.10
0.61
1.2
1.3
270.29
273.78
u/ml
0.05
115
1053
59
696
0.85
0.61
1.4
1.3
164.25
182.06
pmol/l
0.44
59
696
104
918
1.13
0.61
1.2
1.2
—
—
—
0
0
119
1061
1.12
0.60
1.3
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.5
—
4.53
—
0
22
231
2134
1.08
0.58
1.8
1.6
13076.17
12429.71
e6/l
0.10
172
1487
97
1097
0.88
0.58
1.1
1.3
7.83
7.28
mmol/l
0.85
85
974
37
300
1.23
0.58
1.1
1.1
—
—
—
0
0
6
35
1.71
0.57
6.7
7.9
110.67
106.14
g/l
—
6
35
806
8384
0.96
0.57
1.4
1.4
—
—
—
0
0
75
651
1.15
0.57
3.2
2.7
24.88
28.66
mg/l
0.43
50
477
22
167
1.32
0.56
6.7
6.1
9.05
7.83
%
0.48
22
167
678
6494
1.05
0.56
2.8
2.5
6.04
6.05
ph
0.17
444
4321
28
221
1.27
0.55
1.5
2.2
16.63
0.24
e9/l
0.73
12
108
21
159
1.32
0.55
1.2
1.3
0.83
156.71
mg/l
1.73
14
118
133
1470
0.90
0.55
1.6
1.5
54.04
61.01
ug/l
1.25
109
1210
107
955
1.12
0.54
2.3
2.4
16.19
26.45
iu/ml
1.34
14
107
22
168
1.31
0.54
3.4
3.0
43.86
43.76
%
0.01
22
168
8
122
0.66
0.54
1.3
1.6
—
—
—
0
0
69
598
1.15
0.54
2.2
1.8
7.81
6.67
mmol/l
1.31
53
422
564
5384
1.05
0.54
1.3
1.3
60.75
55.86
au/ml
0.19
36
370
21
272
0.77
0.53
1.1
1.2
—
—
—
0
0
3521
34701
1.02
0.51
1.9
1.9
1.39
1.38
mmol/l
0.13
2959
29468
9
134
0.67
0.51
1.6
1.2
61.67
63.95
ug/l
—
9
134
321
3021
1.06
0.51
2.5
2.3
9.91
10.24
g/l
0.87
277
2731
377
3566
1.06
0.51
1.8
1.9
—
—
—
0
0
9
64
1.41
0.51
1.2
1.2
—
18.71
—
0
21
139
1265
1.10
0.51
1.1
1.1
121.67
116.78
%
1.21
132
1152
94
838
1.12
0.50
1.7
2.1
—
—
—
0
0
55
472
1.17
0.50
1.1
1.1
—
—
—
0
0
17
127
1.34
0.49
1.0
1.1
96.64
80.32
ug/l
0.67
11
103
465
4433
1.05
0.48
1.1
1.1
—
—
—
0
0
11
155
0.71
0.48
1.2
1.1
0.54
0.70
umol/24h
—
5
75
1587
15498
1.03
0.48
1.3
1.3
24.93
32.27
iu/ml
1.91
458
4740
311
2933
1.06
0.48
1.7
1.7
—
—
—
0
0
22
172
1.28
0.48
1.1
1.4
—
—
—
0
0
49
419
1.17
0.47
1.2
1.6
7.37
12.31
nmol/l
0.28
38
335
220
2052
1.07
0.47
1.1
1.1
7.59
6.97
eliau/ml
0.08
32
284
1475
14395
1.03
0.47
1.3
1.3
9.30
11.36
u/ml
0.63
565
5757
19
146
1.30
0.46
2.1
2.6
98.54
98.10
ng/l
—
7
61
167
1542
1.08
0.46
1.1
1.3
52.21
33.20
u/l
0.42
145
1338
298
3157
0.94
0.46
1.1
1.1
0.54
0.63
ratio
2.17
32
405
45
526
0.85
0.46
1.1
1.1
4.85
11.34
nmol/l
—
9
102
101
911
1.11
0.46
2.9
3.7
58.44
57.49
%
0.17
86
789
19
243
0.78
0.45
1.6
1.6
9.68
9.21
ug/l
0.25
19
243
74
656
1.13
0.45
1.2
1.2
402.37
363.92
nmol/l
0.80
62
559
22
174
1.26
0.44
1.2
1.1
—
—
—
0
0
38
449
0.85
0.44
1.1
1.0
0.34
1.10
u/ml
—
10
107
16
121
1.32
0.44
10.0
12.1
6.21
5.46
mmol/l
0.28
16
121
56
488
1.15
0.44
1.2
1.2
0.77
0.74
ratio
0.06
35
284
18
230
0.78
0.43
1.6
1.2
9.99
12.44
pmol/l
—
8
89
101
915
1.10
0.43
1.3
1.3
1.59
1.50
nmol/l
0.30
90
827
360
3783
0.95
0.43
1.2
1.1
186.94
197.96
titre
0.06
18
108
78
698
1.12
0.42
1.2
1.2
106.71
108.58
pmol/l
0.14
78
698
944
9714
0.97
0.41
2.0
2.0
3.59
3.52
ratio
0.99
737
7526
72
642
1.12
0.41
1.5
1.3
2.45
2.19
u/ml
0.06
45
372
0
16
0.00
0.41
0.0
1.2
—
0.45
—
0
16
7379
73418
1.02
0.41
5.4
5.2
1.90
1.89
mu/l
0.25
6876
68358
41
351
1.17
0.41
3.0
3.1
—
—
—
0
0
270
2553
1.06
0.41
2.0
1.7
0.23
0.24
g/l
0.27
254
2436
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
1097
10690
1.03
0.40
3.8
3.3
4.68
4.50
e9/l
0.38
961
9315
76
681
1.12
0.40
1.2
1.2
—
—
—
0
0
5
34
1.47
0.40
5.2
5.4
1.48
0.84
mg/l
—
5
26
65
577
1.13
0.40
2.4
2.6
187.98
226.83
e6/l
0.72
54
491
44
508
0.87
0.40
2.8
2.8
32.33
40.31
%
1.31
18
278
22
177
1.24
0.40
1.8
2.1
17.82
17.22
umol/l
0.06
22
177
237
2512
0.94
0.39
1.1
1.1
—
—
—
0
0
565
5448
1.04
0.39
1.4
1.3
245.17
256.08
u/ml
0.07
537
5077
29
242
1.20
0.38
1.2
1.2
769.79
361.72
ug/l
0.26
20
126
121
1115
1.09
0.38
2.6
2.5
—
—
—
0
0
221
2083
1.06
0.38
1.3
1.2
—
—
—
0
0
227
2142
1.06
0.38
1.3
1.3
20.17
25.13
u/ml
—
6
19
36
308
1.17
0.37
1.4
1.1
—
—
—
0
0
215
2027
1.06
0.37
1.2
1.3
1.45
3.23
u/ml
0.89
16
135
74
820
0.90
0.37
1.4
1.4
1.00
1.29
promille
1.01
59
647
136
1262
1.08
0.37
1.2
1.2
—
—
—
0
0
31
262
1.18
0.36
1.3
1.1
—
—
—
0
0
84
924
0.91
0.36
1.6
1.4
281.52
278.58
mosm/kgh2o
0.41
63
711
14
180
0.78
0.36
1.4
1.6
0.47
0.51
e9/l
0.32
14
180
5
78
0.64
0.35
1.2
1.2
1.40
1.72
umol/24h
—
5
78
166
1770
0.94
0.35
7.0
7.2
105.61
105.16
mmol/l
0.63
155
1600
6718
67531
0.98
0.35
23.0
20.5
332.65
332.65
g/l
0.02
6693
67162
51
575
0.89
0.35
1.5
1.6
82.51
83.20
umol/l
0.07
51
575
53
596
0.89
0.35
1.1
1.0
719.72
738.51
ng/l
0.13
43
410
166
1769
0.94
0.34
7.0
7.2
11.17
11.37
mmol/l
0.40
155
1599
7935
79062
1.02
0.34
5.2
5.1
4.60
4.64
mmol/l
1.91
7494
74651
33
383
0.86
0.34
2.0
2.1
68.50
153.16
ug/min
—
8
95
11
82
1.34
0.34
2.2
2.6
172.27
410.88
umol/l
0.58
11
76
20
163
1.23
0.34
1.6
1.9
—
—
—
0
0
8041
80133
1.02
0.34
5.8
5.8
2.70
2.73
mmol/l
1.84
7565
75342
141
1509
0.93
0.33
1.4
1.4
67.85
61.58
mmol/l
0.91
113
1202
53
594
0.89
0.33
1.1
1.0
308.76
318.70
ng/l
0.10
42
426
17
136
1.25
0.33
1.7
3.0
14.68
14.94
ml/dl
0.16
17
128
111
1028
1.08
0.33
1.7
1.5
4439.19
2345.94
e6/l
0.34
75
724
26
219
1.19
0.33
5.9
6.9
5.72
5.47
kpa
0.20
26
219
745
7251
1.03
0.32
1.4
1.4
—
—
—
0
0
397
3822
1.04
0.32
3.7
3.7
45.79
58.79
u/ml
0.53
388
3688
330
3165
1.04
0.32
2.0
1.9
38.79
40.60
nmol/l
0.70
324
3090
276
2636
1.05
0.32
2.0
1.7
1.18
1.20
g/l
0.38
262
2522
262
2500
1.05
0.31
1.3
1.3
221.26
218.93
miu/ml
0.03
108
1115
51
455
1.12
0.31
2.5
2.2
204.06
197.37
u/l
0.30
51
450
814
7937
1.03
0.31
2.3
2.4
384.56
373.39
nmol/l
0.48
766
7375
13
101
1.29
0.31
2.6
3.6
47.00
40.03
umol/l
0.57
13
83
14
110
1.27
0.31
1.1
2.4
1.49
1.10
mmol/l
—
9
72
7
52
1.35
0.31
2.3
1.5
0.21
0.80
%
—
7
34
35
400
0.87
0.30
1.2
1.2
9.89
10.37
mm/h
0.09
35
400
32
277
1.16
0.30
1.0
1.0
—
—
—
0
0
25
212
1.18
0.30
1.2
1.4
447.28
413.33
mu/l
0.16
25
203
36
315
1.14
0.30
2.3
1.4
31.94
33.13
nmol/l
0.09
31
278
1776
18032
0.98
0.30
3.1
3.1
0.78
0.77
ug/l
0.16
1159
11485
33
287
1.15
0.30
1.2
1.2
29.55
28.05
s
0.52
33
287
1182
11592
1.02
0.30
1.3
1.2
—
—
—
0
0
103
957
1.08
0.29
1.3
1.4
—
—
—
0
0
389
3754
1.04
0.29
1.2
1.2
—
—
—
0
0
18
148
1.22
0.29
1.5
1.1
—
—
—
0
0
18
148
1.22
0.29
1.5
1.1
—
—
—
0
0
18
148
1.22
0.29
1.5
1.1
—
—
—
0
0
1612
15867
1.02
0.29
3.2
3.1
2.45
2.45
mmol/l
0.28
1431
14219
2391
24201
0.98
0.28
4.3
4.3
21.82
21.96
%
0.17
1170
11501
411
4250
0.97
0.28
1.6
1.7
—
—
—
0
0
120
1280
0.94
0.28
1.5
1.4
0.36
0.35
nmol/l
0.02
95
948
10
76
1.32
0.28
1.0
1.1
—
—
—
0
0
45
403
1.12
0.27
1.3
1.5
3.71
3.80
%
—
7
91
45
501
0.90
0.27
1.0
1.1
1.27
1.67
u/ml
0.15
20
153
78
844
0.92
0.27
1.1
1.2
—
—
—
0
0
76
701
1.08
0.27
1.1
1.2
269.23
196.28
titre
0.23
13
121
25
215
1.16
0.26
1.2
1.4
73.64
72.91
%
0.08
25
206
30
342
0.88
0.26
1.0
1.1
598.29
300.55
ng/l
—
7
87
140
1323
1.06
0.26
1.2
1.3
5.19
4.35
u/ml
0.20
59
612
86
799
1.08
0.26
1.2
1.1
—
—
—
0
0
43
478
0.90
0.26
1.2
1.2
—
—
—
0
0
9
72
1.25
0.25
1.0
1.1
—
—
—
0
0
30
263
1.14
0.25
1.4
1.1
950.00
1054.24
titre
—
8
59
56
511
1.10
0.25
1.3
1.5
5.12
6.05
u/l
1.07
43
450
43
387
1.11
0.25
5.2
4.9
4800.19
662.46
mg/l
0.40
32
280
46
416
1.11
0.24
2.1
2.3
17.78
29.91
umol/l
—
5
39
342
3308
1.04
0.24
1.3
1.3
1.51
1.03
u/ml
0.20
26
272
652
6371
1.03
0.24
2.8
3.0
207.51
193.81
ng/l
0.15
586
5819
7885
78634
1.02
0.23
5.1
5.0
1.42
1.44
mmol/l
3.23
7404
73809
265
2555
1.04
0.23
5.5
6.1
1.26
1.32
mmol/l
0.82
244
2268
33
369
0.89
0.22
2.0
1.8
1.90
1.72
u/ml
0.07
11
111
38
342
1.11
0.22
4.1
2.5
—
—
—
0
0
11
88
1.25
0.22
6.0
3.2
21.75
28.11
mg/mmol
0.36
11
79
263
2538
1.04
0.22
1.2
1.2
935.00
773.90
titre
—
8
77
5
40
1.25
0.22
1.0
1.1
48.30
36.08
s
—
5
35
46
419
1.10
0.22
1.6
1.8
93.84
137.58
umol/l
1.14
19
211
504
5166
0.97
0.22
4.0
3.5
4.46
4.49
pmol/l
0.33
459
4652
5
41
1.22
0.22
1.0
1.0
0.12
2.08
u/ml
—
5
34
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
0.15
—
0
5
0
11
0.00
0.21
0.0
1.2
—
16.26
—
0
5
111
1172
0.95
0.21
1.6
1.5
—
—
—
0
0
12
98
1.22
0.21
6.1
8.9
0.21
0.19
%
0.18
12
98
5
43
1.16
0.21
1.2
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
34.75
—
0
13
20
173
1.16
0.20
1.1
1.2
207.64
310.82
pmol/l
1.87
14
127
35
387
0.90
0.20
1.1
1.1
1.33
15.35
u/ml
—
6
40
162
1691
0.96
0.20
1.5
1.4
—
—
—
0
0
50
460
1.09
0.20
1.2
1.1
—
—
—
0
0
10
80
1.25
0.20
1.2
1.1
5.93
6.08
mmol/l
—
10
80
0
14
0.00
0.20
0.0
1.0
—
2604.29
—
0
14
0
14
0.00
0.20
0.0
1.0
—
0.17
—
0
7
9
113
0.80
0.20
1.2
1.7
—
—
—
0
0
6
50
1.20
0.19
1.3
1.1
—
—
—
0
0
6
50
1.20
0.19
1.7
2.1
1.83
2.64
mg/l
—
6
41
98
928
1.06
0.19
1.1
1.1
—
—
—
0
0
106
1116
0.95
0.19
1.6
1.5
1.31
1.26
mm
0.34
71
791
121
1153
1.05
0.19
1.1
1.1
—
—
—
0
0
13
154
0.84
0.19
2.5
2.9
—
—
—
0
0
76
715
1.06
0.18
1.1
1.1
278.12
284.19
mg/l
0.34
66
658
120
1257
0.95
0.18
1.1
1.1
1.47
1.51
g/l
0.59
107
1160
44
405
1.09
0.18
36.9
27.8
112.57
113.58
ug/l
0.04
38
323
56
601
0.93
0.18
1.1
1.1
5.16
9.09
iu/ml
1.58
18
166
70
745
0.94
0.18
5.4
5.6
125.57
68.55
u/ml
0.45
28
253
14
119
1.18
0.17
1.5
1.6
9.79
271436.21
nmol/l
0.72
14
98
68
639
1.06
0.17
1.1
1.1
409.69
272.94
mg/l
0.85
59
560
34
310
1.10
0.17
2.5
3.0
26.73
28.38
umol/l
0.52
24
224
96
913
1.05
0.17
1.7
1.4
61406.57
61357.92
e6/l
0.00
49
522
7
63
1.11
0.17
2.3
1.4
—
—
—
0
0
5
69
0.72
0.16
1.2
1.5
37.00
44.42
umol/l
—
5
69
5
69
0.72
0.16
1.8
1.2
—
—
—
0
0
7657
76401
1.01
0.16
5.2
5.1
5.98
5.95
mmol/l
1.42
7096
70928
690
6790
1.02
0.16
1.8
1.8
—
—
—
0
0
220
2135
1.03
0.16
1.4
1.3
598.15
540.86
mg/l
0.68
210
2039
30
273
1.10
0.16
1.0
1.1
—
—
—
0
0
43
463
0.93
0.16
1.1
1.1
1550.81
1506.41
miu/ml
0.10
43
463
47
504
0.93
0.15
1.4
1.6
21.13
23.68
umol/l
0.26
40
464
532
5226
1.02
0.15
2.1
2.0
1.13
1.35
g/l
2.62
492
4843
70
739
0.95
0.15
3.6
3.0
70.20
51.00
mg/l
0.30
48
545
5688
57064
0.99
0.14
4.1
4.0
8.67
3794.73
—
6
114
98
938
1.05
0.14
2.4
2.0
37.57
24.34
mg/l
1.19
44
335
7
86
0.81
0.14
1.0
1.1
—
—
—
0
0
42
391
1.07
0.14
1.8
1.6
—
—
—
0
0
42
391
1.07
0.14
3.0
3.0
—
—
—
0
0
7
89
0.79
0.14
1.3
1.4
68.29
76.85
%
—
7
75
136
1409
0.96
0.14
1.1
1.1
1.31
1.35
u/ml
0.03
72
685
262
2559
1.02
0.13
1.3
1.3
186.36
114.45
titre
0.59
22
245
139
1437
0.97
0.13
2.0
1.6
—
—
—
0
0
93
892
1.04
0.13
2.1
1.7
423.67
360.18
mu/l
0.42
78
704
16
180
0.89
0.13
1.4
2.2
—
—
—
0
0
3035
30190
1.01
0.13
5.1
5.3
2.98
2.92
ug/l
0.06
2731
27505
53
501
1.06
0.12
6.6
7.1
20.91
118.21
ug/l
1.31
34
327
33
355
0.93
0.12
1.5
1.6
2624.00
3223.70
titre
—
5
54
239
2335
1.02
0.12
2.1
2.1
11.83
11.77
mg/l
0.04
225
2194
194
1991
0.97
0.12
2.7
2.9
34.76
35.02
umol/l
0.04
184
1805
28
258
1.09
0.12
1.3
1.1
—
—
—
0
0
416
4091
1.02
0.12
2.3
2.4
—
—
—
0
0
14
158
0.89
0.12
1.6
1.6
—
—
—
0
0
46
487
0.94
0.11
2.2
1.5
12.32
7.91
ug/l
0.38
39
438
85
817
1.04
0.11
1.2
1.2
—
—
—
0
0
121
1249
0.97
0.11
1.0
1.1
5.03
3.42
u/ml
0.36
62
609
69
660
1.05
0.11
1.1
1.1
61.77
42.37
mg/l
0.98
61
554
19
172
1.10
0.11
4.6
4.6
41.84
69.01
u/l
1.14
19
164
54
513
1.05
0.11
1.9
2.0
106.99
114.30
ng/l
0.21
54
513
134
1380
0.97
0.11
1.1
1.1
15.55
15.33
au/ml
0.01
41
338
12
105
1.14
0.11
1.9
1.5
—
—
—
0
0
162
1579
1.03
0.10
1.1
1.1
—
—
—
0
0
68
709
0.96
0.10
4.2
4.3
28.40
53.41
u/ml
2.05
68
703
817
8252
0.99
0.10
2.6
2.3
12.61
13.40
nmol/l
1.97
752
7496
110
1135
0.97
0.10
1.6
1.5
—
—
—
0
0
898
9065
0.99
0.10
1.6
1.6
—
6.23
—
0
7
568
5611
1.01
0.10
1.2
1.3
—
—
—
0
0
19
173
1.10
0.10
1.0
1.1
12.66
41.19
iu/ml
5.62
19
173
23
212
1.09
0.10
1.4
1.3
42.54
38.99
%
0.13
13
143
189
1848
1.02
0.10
3.8
4.1
—
—
—
0
0
132
1356
0.97
0.10
1.5
1.4
—
—
—
0
0
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
52
496
1.05
0.10
1.1
1.0
—
—
—
0
0
179
1750
1.02
0.10
1.3
1.3
—
—
—
0
0
191
1869
1.02
0.10
1.4
1.4
17.52
30.78
e6/l
0.71
130
1368
29
271
1.07
0.09
1.0
1.1
—
—
—
0
0
36
340
1.06
0.09
1.9
2.1
29.36
31.63
%
0.37
36
340
114
1172
0.97
0.09
1.1
1.1
2.55
3.65
u/ml
0.43
52
507
67
646
1.04
0.08
1.8
2.1
69.23
72.95
%
0.85
62
618
6
57
1.05
0.08
1.0
1.1
—
—
—
0
0
6
58
1.03
0.08
1.0
1.1
—
18.33
—
0
6
105
1078
0.97
0.08
1.0
1.1
1.86
0.31
u/ml
0.59
35
342
7
65
1.08
0.08
1.0
1.0
—
—
—
0
0
77
794
0.97
0.07
1.6
2.0
15.93
7.33
umol/l
0.67
58
570
87
846
1.03
0.07
1.5
1.4
—
—
—
0
0
172
1751
0.98
0.07
1.1
1.1
0.90
1.84
u/ml
2.60
98
903
59
570
1.04
0.07
1.1
1.2
—
—
—
0
0
26
245
1.06
0.07
1.1
1.1
—
—
—
0
0
26
245
1.06
0.07
1.1
1.1
—
—
—
0
0
26
245
1.06
0.07
1.1
1.1
—
—
—
0
0
7
85
0.82
0.07
1.0
1.1
—
—
—
0
0
161
1581
1.02
0.07
1.1
1.1
—
—
—
0
0
80
780
1.03
0.06
1.5
1.4
8.83
3.32
ug/l
0.51
67
665
312
3154
0.99
0.06
2.5
2.7
—
—
—
0
0
42
436
0.96
0.06
1.5
1.7
—
—
—
0
0
17
182
0.93
0.05
1.0
1.1
—
19.43
—
0
7
10
90
1.11
0.05
2.2
2.3
28.65
22.50
mg/l
—
10
83
10
90
1.11
0.05
1.5
1.2
7.38
10.63
mg/l
—
10
81
21
198
1.06
0.05
1.2
1.2
—
—
—
0
0
149
1513
0.98
0.05
1.8
1.6
0.64
0.82
g/l
1.63
115
1198
89
909
0.98
0.05
1.4
1.4
2.77
3.04
g/l
0.87
65
667
3306
33130
1.00
0.05
3.2
3.1
—
—
—
0
0
89
908
0.98
0.05
1.4
1.4
0.53
0.43
g/l
0.29
66
666
89
908
0.98
0.05
1.4
1.4
6.23
6.76
g/l
0.85
65
664
54
555
0.97
0.04
1.1
1.1
—
—
—
0
0
252
2545
0.99
0.04
1.6
1.6
1286.82
1007.23
mu/l
0.62
204
2111
192
1899
1.01
0.04
1.4
1.4
233.68
3185.93
e6/l
0.85
141
1486
110
1084
1.01
0.03
1.2
1.3
69.49
67.63
u/ml
—
8
67
190
1882
1.01
0.03
1.3
1.3
3.85
3.79
mmol/l
0.27
183
1777
36
371
0.97
0.03
1.1
1.1
—
—
—
0
0
94
926
1.02
0.03
3.0
2.5
—
—
—
0
0
145
1466
0.99
0.03
1.1
1.1
2.20
0.99
u/ml
0.52
72
618
401
4030
0.99
0.03
3.4
3.4
1.02
1.02
ratio
0.17
348
3649
13
122
1.07
0.02
1.0
1.1
0.07
1.55
u/ml
—
7
78
148
1493
0.99
0.02
1.1
1.1
—
—
—
0
0
33
321
1.03
0.02
1.3
1.1
—
—
—
0
0
200
2014
0.99
0.02
1.2
1.3
—
—
—
0
0
90
889
1.01
0.02
1.4
1.4
—
—
—
0
0
124
1229
1.01
0.02
1.3
1.3
32.56
29.04
u/l
0.55
105
1008
70
709
0.99
0.01
1.1
1.1
—
—
—
0
0
151
1520
0.99
0.01
1.1
1.1
5.29
4.41
u/ml
0.22
80
767
18
173
1.04
0.01
1.4
1.3
—
—
—
0
0
18
187
0.96
0.01
1.4
2.7
14.67
225.35
ug/l
0.75
18
187
188
1890
0.99
0.01
1.2
1.2
—
—
—
0
0
147
1479
0.99
0.01
1.1
1.1
—
—
—
0
0
414
4151
1.00
0.01
1.4
1.4
28.67
30.10
iu/l
0.39
353
3557
35
357
0.98
0.01
2.1
1.7
1197.98
411.58
pmol/l
—
8
65
53
523
1.01
0.01
1.3
1.4
52.00
505.48
titre
—
5
42
19
193
0.98
0.00
1.1
1.1
0.39
1.65
u/ml
1.18
13
100
12
124
0.97
0.00
2.5
2.6
6.35
4.19
ug/l
—
6
44
24
239
1.00
0.00
1.1
1.2
—
—
—
0
0
48
481
1.00
0.00
1.5
2.2
16.09
16.11
%
0.01
48
481
19
191
0.99
0.00
1.6
2.2
—
—
—
0
0
110
1102
1.00
0.00
1.1
1.1
3.01
3.36
eliau/ml
0.09
61
533
84
842
1.00
0.00
1.5
1.5
—
—
—
0
0
33
327
1.01
0.00
3.8
2.7
0.61
0.61
mmol/l
0.14
33
327
19
185
1.03
0.00
1.5
1.4
27.79
22.52
%
0.32
14
155
124
1235
1.00
0.00
1.2
1.2
—
—
—
0
0
11
112
0.98
0.00
1.1
1.6
7.54
7.28
mmol/l
—
5
38
18
177
1.02
0.00
1.6
1.2
—
—
—
0
0
16
164
0.98
0.00
1.5
1.2
1.54
1.60
mmol/l
0.12
11
105
12
120
1.00
0.00
4.7
6.7
7.69
8.41
mmol/l
0.67
12
120
12
120
1.00
0.00
1.0
1.1
—
—
—
0
0
20
197
1.02
0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.6
2.3
0.70
0.59
ug/l
—
5
58
6
67
0.90
-0.00
2.2
2.9
—
70.96
—
0
29
0
5
0.00
-0.00
0.0
1.0
—
1.82
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
59
1.02
-0.00
1.5
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
41.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
38.18
—
0
5
7
77
0.91
-0.00
1.0
1.1
0.02
0.03
u/ml
—
7
77
0
6
0.00
-0.00
0.0
1.0
—
0.43
—
0
6
0
8
0.00
-0.00
0.0
1.9
—
11.63
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
79
0.89
-0.00
1.0
1.1
118.86
100.86
titre
—
7
79
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
63
0.95
-0.00
2.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.08
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
13.67
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
75.84
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
304.80
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
163.29
—
0
7
6
68
0.88
-0.00
1.0
1.1
—
13.14
—
0
15
0
9
0.00
-0.00
0.0
1.1
—
1470.00
—
0
9

Mortality – FinRegistry

Association

Association between endpoint APPENDACUT_COMPLIC and mortality.

Females

Parameter HR [95% CI] p-value
APPENDACUT_COMPLIC 1.249 [1.12, 1.4] < 0.001
Birth year 0.992 [0.98, 1.0] 0.049

During the follow-up period (1.1.1998 — 31.12.2019), 1325 out of 13079 females with APPENDACUT_COMPLIC died.

Males

Parameter HR [95% CI] p-value
APPENDACUT_COMPLIC 1.119 [1.01, 1.25] 0.04
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 1714 out of 14440 males with APPENDACUT_COMPLIC died.

Mortality risk

Mortality risk for people of age

years, who have APPENDACUT_COMPLIC.

N-year risk Females Males
1 0.088% 0.216%
5 0.567% 1.277%
10 1.541% 3.117%
15 2.994% 5.806%
20 5.332% 10.039%

Relationships between endpoints

Index endpoint: APPENDACUT_COMPLIC – Acute appendicitis, with complications

GWS hits: 7

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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