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Polycystic ovarian syndrome, broad definition

Endpoint Browser PheWeb

E4_PCOS_BROAD

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

  • not E4_PCOS_BROAD_EXCLUSIONS
288920

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

5102

6. Filter based on genotype QC (FinnGen only)

5102

Control definitions (FinnGen only)

Control conditions
not E4_PCOS_BROAD_EXCLUSIONS

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF6v3

Case counts by codes

↥

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 29153 29153 -
Only index persons 28858 28858 -
Unadjusted period prevalence (%)
Whole population 0.84 0.84 -
Only index persons 1.06 1.06 -
Median age at first event (years)
Whole population - 29.08 -
Only index persons - 29.06 -

-FinnGen-

Key figures

All Female Male
Number of individuals 5102 5102 -
Unadjusted period prevalence (%) 1.74 1.74 -
Median age at first event (years) 29.47 29.47 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
4478
Matched controls
44779
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N97.9
ICD-10 Finland
Female infertility, unspecified
9.9
323.0
1808
2854
A10BA02
ATC
metformin; oral
5.7
323.0
1240
2830
G03GA01
ATC
chorionic gonadotrophin; parenteral
12.3
323.0
1426
1636
G03GA06
ATC
follitropin beta; parenteral
10.2
323.0
741
857
L02BG04
ATC
letrozole; oral
9.7
323.0
1024
1333
G03DB01
ATC
dydrogesterone; oral
6.8
323.0
2138
5329
TLW00
NOMESCO Finland
Insemination
11.2
323.0
716
748
LA2AE
NOMESCO Finland
Ultrasound examination of ovarian cyst
10.6
323.0
822
932
G03GA05
ATC
follitropin alfa; parenteral
8.2
323.0
900
1326
N97.0
ICD-10 Finland
Female infertility associated with anovulation
2957.1
323.0
2962
29
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
12.4
323.0
1093
1136
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
208.9
323.0
1862
152
G03GA02
ATC
human menopausal gonadotrophin; parenteral
9.4
319.9
707
875
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
8.4
319.2
761
1069
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
5.6
277.0
911
1964
N97.4
ICD-10 Finland
Female infertility associated with male factors
8.9
259.1
587
745
G03GB02
ATC
clomifene; oral
12.2
256.6
487
443
H01CC01
ATC
ganirelix; parenteral
6.8
242.4
664
1120
G03DA04
ATC
progesterone; systemic, rectal, vaginal
8.2
223.5
530
718
H01CA02
ATC
nafarelin; nasal
6.6
217.9
607
1040
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.7
215.6
2599
15162
TLW12
NOMESCO Finland
Insertion of frozen embryo
8.3
215.5
506
673
N91.1
ICD-10 Finland
Secondary amenorrhoea
7.7
213.8
531
771
6280A
ICD-9 Finland
Infertility, female, Associated with anovulation[STERILITAS ET INFERTILITAS ANOVULATORIA PRIM]
+∞
204.8
195
*
TLW10
NOMESCO Finland
Transfer of fresh embryo
7.4
190.5
485
726
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.7
133.1
1138
5069
N97.8
ICD-10 Finland
Female infertility of other origin
5.3
128.1
418
849
L02AE01
ATC
buserelin; implant, nasal, parenteral
10.2
127.3
262
272
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.3
113.3
1389
7374
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
6.7
111.8
300
475
N97.1
ICD-10 Finland
Female infertility of tubal origin
8.9
109.6
243
287
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.2
108.6
1389
7491
2564A
ICD-9 Finland
Ovarian dysfunction, Polycystic ovaries
+∞
102.5
98
*
E66.01
ICD-10 Finland
Obesity due to excess calories
2.9
101.9
700
2678
Z31.2
ICD-10 Finland
In vitrofertilization
8.8
97.7
217
257
LA2HE
NOMESCO Finland
Repeated measurement of ovarian cyst
8.9
96.6
214
252
Z31.1
ICD-10 Finland
Artificial insemination
13.6
96.5
171
130
6280B
ICD-9 Finland
Infertility, female, Associated with anovulation[STERILITAS ET INFERTILITAS ANOVULATORIA SEC]
+∞
96.2
92
*
N98.1
ICD-10 Finland
Hyperstimulation of ovaries
12.6
95.8
176
145
L68.0
ICD-10 Finland
Hirsutism
11.2
95.8
186
172
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
2.1
90.2
1332
7526
LAA06
NOMESCO Finland
Transvaginal puncture of ovarian cyst
8.9
90.2
199
233
1410
FHL
Laparoscopy
6.1
73.4
209
356
G03GA04
ATC
urofollitropin; parenteral
11.3
71.5
138
126
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.0
70.1
1031
5710
TLW20
NOMESCO Finland
Medical ovulation induction
26.5
68.8
96
37
G03DC02
ATC
norethisterone; oral
2.8
68.3
498
1945
1413
FHL
Laparoscopy and other therapeutic procedure
6.7
67.6
178
273
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
8.4
66.6
151
185
E66.8
ICD-10 Finland
Other obesity
3.0
63.2
404
1450
LBF00
NOMESCO Finland
Perfusion of Fallopian tube
11.7
60.8
115
101
G03HB01
ATC
cyproterone and estrogen; systemic
1.9
59.0
1070
6356
TLW14
NOMESCO Finland
ICSI
5.8
56.6
166
294
JAH01
NOMESCO Finland
Laparoscopy
2.8
52.5
355
1317
25690
ICD-8 Finland
Ovarian dysfunction, Syndroma Stein-Leventhal
+∞
52.2
50
*
W15
ICPC
Infertility/subfertility female
5.1
49.5
161
322
G03DA02
ATC
medroxyprogesterone; systemic (pregnen (4) derivatives)
2.9
46.8
297
1056
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.8
46.7
930
5641
LA2JE
NOMESCO Finland
Follow-up of menstrual cycle with repeated measurement of ovarian cyst
6.9
46.3
119
177
LCA30
NOMESCO Finland
Transfer of oocyte or embryo to uterus in assisted fertilisation
10.1
45.9
93
94
L02AE02
ATC
leuprorelin; implant, parenteral
3.9
44.8
194
516
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.1
44.5
569
2920
E66.9
ICD-10 Finland
Obesity, unspecified
3.1
43.5
257
871
N91.5
ICD-10 Finland
Oligomenorrhoea, unspecified
7.0
42.6
108
158
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.7
42.1
1027
6607
XLA10
NOMESCO Finland
NA
2.7
41.5
295
1125
E66.00
ICD-10 Finland
Metabolic syndrome
3.4
40.4
204
616
N91.3
ICD-10 Finland
Primary oligomenorrhoea
13.7
39.7
69
51
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
2.3
38.4
386
1774
SPAT1379
SPAT
Health check-up of pregnant person
1.6
37.5
1414
10173
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
37.4
1488
10841
G03FB06
ATC
medroxyprogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
3.7
36.7
168
469
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
5.6
36.6
109
198
W78
ICPC
Pregnancy
1.5
36.1
1759
13399
O02.1
ICD-10 Finland
Missed abortion
2.0
35.3
528
2869
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.3
34.9
349
1596
T90
ICPC
Diabetes non-insulin dependent
2.1
33.2
384
1877
H01CC02
ATC
cetrorelix; parenteral
6.2
31.7
87
143
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.9
31.0
474
2589
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
30.9
477
2615
X05
ICPC
Menstruation absent/scanty
3.2
30.6
170
552
O30.0
ICD-10 Finland
Twin pregnancy
3.0
30.3
180
611
ULC02
NOMESCO Finland
Hysteroscopy
2.3
29.8
288
1296
C03DA01
ATC
spironolactone; oral
2.7
29.6
216
836
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
3.6
29.5
137
388
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
2.5
29.1
233
950
Z31.3
ICD-10 Finland
Other assisted fertilization methods
7.3
28.9
70
97
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.6
28.8
889
6015
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
1.9
28.7
447
2455
Z32.0
ICD-10 Finland
Pregnancy, not (yet) confirmed
2.2
28.2
306
1452
8117
FHL
Pertubatio
31.1
28.1
37
12
Z31.4
ICD-10 Finland
Procreative investigation and testing
3.9
27.3
115
301
N97
ICD-10 Finland
Female infertility
3.9
26.9
112
290
SPAT1197
SPAT
Extensive health check-up of expecting family
1.4
26.6
1517
11726
N02BE01
ATC
paracetamol; systemic, rectal
1.5
26.5
3535
32028
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
1.7
26.1
566
3465
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
25.8
819
5562
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
2.2
25.5
283
1358
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
25.4
1716
13663
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
25.2
1921
15626
SPAT1262
SPAT
Handing over of treatment supplies
1.8
25.1
463
2690
B01AB05
ATC
enoxaparin; parenteral
1.6
25.1
852
5873
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.7
24.7
614
3904
SPAT1310
SPAT
Counselling related to known health issue
1.4
24.7
1362
10421
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
1.8
23.5
399
2255
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.5
22.7
833
5836
O20.0
ICD-10 Finland
Threatened abortion
2.2
22.4
244
1157
G47.3
ICD-10 Finland
Sleep apnoea
1.7
22.1
460
2774
SPAT1263
SPAT
Sampling
1.4
21.9
1895
15623
W85
ICPC
Gestational diabetes
1.7
21.8
449
2697
H03AA01
ATC
levothyroxine sodium; systemic
1.5
21.8
912
6564
8201
FHL
Ovarian preservation exploration and related procedures, eg resection, enucleation or ovariolysis
4.9
21.7
71
146
SPAT1380
SPAT
Postpartum check-up
1.4
21.5
1136
8570
A10BK03
ATC
empagliflozin; oral
2.7
21.0
142
527
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
0.5
21.0
242
4238
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
0.6
21.0
357
5663
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.6
20.9
536
3430
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
1.5
20.7
850
6084
E66
ICD-10 Finland
Obesity
2.2
20.7
226
1076
LCA06
NOMESCO Finland
Biopsy of endometrium
1.6
20.6
574
3750
W84
ICPC
Pregnancy high risk
1.7
19.9
401
2395
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
1.9
19.8
293
1577
A02BC01
ATC
omeprazole; systemic
1.5
19.7
876
6372
6289A
ICD-9 Finland
Infertility, female, Of unspecified origin[STERILITAS ET INFERTILITAS MULIERIS NUD PRIM]
5.5
19.1
56
102
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.1
19.1
223
1095
N83.1
ICD-10 Finland
Corpus luteum cyst
2.8
19.0
122
440
L02AE03
ATC
goserelin; implant
3.9
18.8
78
203
SPAT1312
SPAT
General health counselling
1.4
18.8
1506
12167
Z35.1
ICD-10 Finland
Supervision of pregnancy with history of abortive outcome
3.9
18.8
77
199
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.7
18.6
432
2684
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
1.6
18.2
501
3260
SPAT1153
SPAT
Removal of sutures
1.4
18.1
881
6511
N02AX02
ATC
tramadol; systemic, rectal
1.4
17.9
1148
8919
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
1.3
17.7
2125
18198
J01DB01
ATC
cefalexin; oral
1.4
17.7
3546
32804
B02AA02
ATC
tranexamic acid; systemic
1.5
17.7
724
5165
J02AC01
ATC
fluconazole; systemic
1.3
17.6
2173
18685
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.7
17.6
383
2339
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.0
17.5
214
1071
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
1.4
17.5
935
7031
O00.1
ICD-10 Finland
Tubal pregnancy
2.3
17.4
159
698
T82
ICPC
Obesity
2.1
17.3
196
949
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
17.2
870
6473
E28.0
ICD-10 Finland
Ovarian dysfunction: Estrogen excess
50.2
17.0
20
*
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
1.3
16.5
1508
12371
Z39.2
ICD-10 Finland
Routine postpartum follow-up
1.3
16.5
1385
11215
O60
ICD-10 Finland
Preterm labour and delivery
1.9
16.4
233
1235
8219
FHL
Other measure in this category
16.8
16.0
25
15
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
15.9
1090
8540
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
15.7
436
2842
N80.1
ICD-10 Finland
Endometriosis of ovary
1.9
15.5
227
1215
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
15.5
731
5351
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.6
15.5
113
442
N80.0
ICD-10 Finland
Endometriosis of uterus
2.3
15.4
138
602
SPAT1301
SPAT
No procedures
1.3
15.3
1154
9164
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.6
15.2
431
2821
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
2.5
15.1
117
472
A10BH01
ATC
sitagliptin; oral
2.5
14.8
118
483
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.8
14.6
252
1428
M54.5
ICD-10 Finland
Low back pain
1.3
14.5
1328
10841
205
Kela drug reimbursment
Chronic hypertension
1.9
14.5
225
1230
LCA96
NOMESCO Finland
Other intrauterine operation
4.7
14.5
48
102
N70.1
ICD-10 Finland
Chronic salpingitis and oophoritis
3.1
14.3
77
250
E28.1
ICD-10 Finland
Ovarian dysfunction: Androgen excess
27.2
14.3
19
7
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
14.1
691
5094
J01CA08
ATC
pivmecillinam; oral
1.3
14.0
2166
18956
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
3.3
13.9
70
216
N96
ICD-10 Finland
Habitual aborter
2.9
13.9
83
289
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
3.5
13.8
63
180
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.7
13.8
302
1845
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.6
13.6
355
2276
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
2.2
13.6
131
593
M01AE02
ATC
naproxen; oral, rectal
1.3
13.5
2429
21622
A02BC02
ATC
pantoprazole; systemic
1.3
13.5
2121
18569
N91.0
ICD-10 Finland
Primary amenorrhoea
5.4
13.3
39
73
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
3.4
13.2
62
182
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.5
13.2
99
395
N80.9
ICD-10 Finland
Endometriosis, unspecified
1.9
12.9
178
936
H02AB06
ATC
prednisolone; systemic
1.3
12.8
1549
13092
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
2.0
12.8
167
860
Z31.6
ICD-10 Finland
General counselling and advice on procreation
2.5
12.8
96
384
O03.4
ICD-10 Finland
Spontaneous abortion, Incomplete, without complication
1.9
12.6
190
1032
LAA97
NOMESCO Finland
Other laparoscopic puncture of ovary
70.1
12.6
14
*
L03
ICPC
Low back symptom/complaint
1.3
12.5
949
7511
8113
FHL
Fractional scraping
2.8
12.4
79
288
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
12.4
1307
10840
SPAT1373
SPAT
Combined screening in early pregnancy
1.8
12.3
203
1137
O34.3
ICD-10 Finland
Maternal care for cervical incompetence
3.2
12.3
63
198
E66.0
ICD-10 Finland
Obesity due to excess calories
4.6
12.3
41
89
W12
ICPC
Contraception intrauterine
0.7
12.1
549
7281
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
12.0
629
4677
C07AB07
ATC
bisoprolol; oral
1.4
12.0
788
6092
LAC21
NOMESCO Finland
Laparoscopic destruction of lesion of ovary
2.5
12.0
91
366
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
12.0
1372
11486
-
ICD-10 Finland
NA
2.9
11.9
71
248
N85.0
ICD-10 Finland
Endometrial glandular hyperplasia
3.0
11.9
69
236
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
3.7
11.9
51
140
P01AB01
ATC
metronidazole; oral, rectal
1.3
11.8
1638
14039
O82.0
ICD-10 Finland
Delivery by elective caesarean section
1.5
11.7
357
2375
O02.0
ICD-10 Finland
Blighted ovum and nonhydatidiform mole
1.7
11.7
235
1400
N92.5
ICD-10 Finland
Other specified irregular menstruation
1.7
11.6
242
1462
SPAT1283
SPAT
Restricted health certificate
1.3
11.5
1321
11049
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
1.5
11.4
476
3393
121
Kela drug reimbursment
Severe hypofunction of sexual glands
2.8
11.4
73
268
6173B
ICD-9 Finland
Endometriosis of pelvic peritoneum[ENDOMETRIOSIS RETROUTERINA]
4.3
11.2
40
93
R03AC02
ATC
salbutamol; inhalant
1.2
11.1
2194
19542
1350
FHL
Hysteroscopy
5.7
11.1
31
55
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.6
11.1
327
2160
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
1.8
11.1
179
999
6173A
ICD-9 Finland
Endometriosis of pelvic peritoneum[ENDOMETRIOSIS SEROSAE PELVIS]
4.7
11.0
36
77
N84.0
ICD-10 Finland
Polyp of corpus uteri
1.7
11.0
238
1451
LCH11
NOMESCO Finland
Pharmacologic abortion
0.6
10.8
178
2861
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
1.8
10.8
189
1081
X07
ICPC
Menstruation irregular/frequent
2.0
10.7
129
647
A02BC03
ATC
lansoprazole; oral
1.3
10.6
729
5669
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
10.5
2448
22146
M54.4
ICD-10 Finland
Lumbago with sciatica
1.4
10.4
560
4184
G03GA30
ATC
gonadotropins - combinations; systemic
3.5
10.3
47
137
6282A
ICD-9 Finland
Infertility, female, Of tubal origin[STERIL ET INFERT EX ORIG TUBAE UTERINAE PRIM]
8.8
10.3
21
24
G03DB02
ATC
megestrol; oral (pregnadien derivatives)
2.9
10.2
60
209
C09CA06
ATC
candesartan; oral
1.4
10.1
531
3947
G03DC03
ATC
lynestrenol; oral
1.9
10.1
135
703
Z30.4
ICD-10 Finland
Surveillance of contraceptive drugs
0.7
9.9
402
5436
M03BX02
ATC
tizanidine; oral
1.2
9.9
2464
22382
SPAT1324
SPAT
Screening procedure
1.3
9.9
1142
9528
6288A
ICD-9 Finland
Infertility, female, Of other specified origin[STERILITAS ET INFERTILITAS MULIERIS ALIA PRIM]
12.2
9.8
17
14
O24.9
ICD-10 Finland
Diabetes mellitus in pregnancy, unspecified
1.9
9.8
149
814
JAL21
NOMESCO Finland
Laparoscopic excision or destruction of lesion of peritoneum
2.0
9.8
114
565
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
9.8
139
741
C09AA02
ATC
enalapril; systemic
1.7
9.7
217
1340
SPAT1260
SPAT
Consultation of another employee
1.4
9.6
600
4588
6350C
ICD-9 Finland
Legally induced abortion, Complicated by genital tract and pelvic infection[ABORTUS PROV LEGAL SINE COMPL,SOSIAALISET SYYT]
0.5
9.6
55
1190
WX306
NOMESCO Finland
Lumbar epidural anesthesy
1.4
9.5
519
3879
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
1.9
9.5
127
664
SPAT1189
SPAT
Other ultrasound examination during pregnancy
1.5
9.5
325
2227
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
9.4
2243
20229
A10BJ06
ATC
semaglutide; parenteral
2.5
9.4
74
304
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.4
9.3
426
3086
SPAT1325
SPAT
Vaccination
1.3
9.3
989
8157
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.4
9.3
383
2721
OAB72
NOMESCO Finland
Weight control and weight loss guidance
3.5
9.2
41
118
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
9.2
1129
9475
N97.2
ICD-10 Finland
Female infertility of uterine origin
7.3
9.2
21
29
62800
ICD-8 Finland
Sterility, female, Sterilitas primaria
5.2
9.2
27
52
SAA01
NOMESCO Finland
Simple examination of mouth
1.2
9.2
3242
30420
O03.1
ICD-10 Finland
Spontaneous abortion, Incomplete, complicated by delayed or excessive haemorrhage
1.9
9.1
124
653
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
0.6
9.1
120
2036
J01AA02
ATC
doxycycline; systemic
1.2
9.1
2792
25795
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.2
9.1
1603
14007
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1.5
9.0
353
2483
E28.3
ICD-10 Finland
Primary ovarian failure
3.9
9.0
35
90
6146A
ICD-9 Finland
Inflammatory disease of ovary, Fallopian tube, pelvic cellular tissue and peritoneum, Pelvic peritoneal adhesions, female
4.5
8.9
30
67
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.5
8.9
282
1898
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
2.5
8.9
68
277
O99.80
ICD-10 Finland
The fear of childbirth
1.4
8.8
440
3245
S18
ICPC
Laceration/cut
1.3
8.8
1084
9096
M01AE01
ATC
ibuprofen; systemic, rectal
1.4
8.8
4027
38889
SPAT1195
SPAT
Antenatal classes
1.5
8.8
309
2127
LBE01
NOMESCO Finland
Laparoscopic salpingectomy
1.7
8.6
161
941
A10BK01
ATC
dapagliflozin; oral
2.2
8.6
81
366
ACC51
NOMESCO Finland
Release of median nerve
1.6
8.6
208
1308
A10BJ02
ATC
liraglutide; parenteral
2.8
8.6
52
186
A02BC05
ATC
esomeprazole; systemic
1.2
8.6
1192
10131
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.3
8.6
562
4330
6282B
ICD-9 Finland
Infertility, female, Of tubal origin[STERIL ET INFERT EX ORIG TUBAE UTERINAE SEC]
6.9
8.5
20
29
L15
ICPC
Knee symptom/complaint
1.3
8.5
547
4201
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
8.5
2499
22907
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.5
8.5
299
2060
C08CA01
ATC
amlodipine; oral
1.4
8.5
363
2599
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
1.8
8.5
134
746
W92
ICPC
Compl labour/ delivery livebirth
1.6
8.4
212
1351
G03AC03
ATC
levonorgestrel; systemic
0.7
8.4
192
2878
R51.80
ICD-10 Finland
Headache
1.3
8.4
707
5651
O00.9
ICD-10 Finland
Ectopic pregnancy, unspecified
2.1
8.3
94
463
C08CA05
ATC
nifedipine; systemic
1.8
8.3
138
780
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
1.5
8.2
254
1700
N02AJ06
ATC
codeine and paracetamol; systemic
1.2
8.1
1316
11360
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.3
8.1
677
5401
N85.1
ICD-10 Finland
Endometrial adenomatous hyperplasia
3.7
8.1
33
89
W29
ICPC
Pregnancy symptom/complaint other
1.5
8.1
253
1696
O80.8
ICD-10 Finland
Other single spontaneous delivery
1.4
8.1
402
2962
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
8.1
624
4926
WX320
NOMESCO Finland
Spinalanesthesy
1.3
8.0
668
5330
OAA11
SPAT
NA
1.5
8.0
265
1804
C09AA05
ATC
ramipril; oral
1.6
8.0
223
1461
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
1.8
7.9
138
792
C10AA01
ATC
simvastatin; oral
1.5
7.9
308
2167
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
7.9
2144
19457
N91
ICD-10 Finland
Absent, scanty and rare menstruation
3.9
7.8
30
77
A10BG03
ATC
pioglitazone; oral
3.7
7.8
32
87
O21.9
ICD-10 Finland
Vomiting of pregnancy, unspecified
1.8
7.8
134
768
M79.6
ICD-10 Finland
Pain in limb
1.2
7.8
1192
10222
MBA00
NOMESCO Finland
Vacuum aspiration from uterus after delivery or abortion
1.7
7.8
141
820
J01DA01
ATC
[U] cefalexin; systemic
1.2
7.8
2445
22463
8216
FHL
Applicatio ovii
10.8
7.8
14
13
G02CB01
ATC
bromocriptine; systemic
2.0
7.8
92
462
B03BA03
ATC
hydroxocobalamin; parenteral
2.0
7.8
94
476
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
7.7
557
4358
C09BA02
ATC
enalapril and diuretics; systemic
2.3
7.7
66
287
UJF32
NOMESCO Finland
Coloscopy
1.3
7.6
522
4049
R06.5
ICD-10 Finland
Mouth breathing
1.6
7.6
191
1219
LEA01
NOMESCO Finland
Culdoscopy
25.0
7.6
10
*
M79.1
ICD-10 Finland
Myalgia
1.3
7.6
514
3982
G03FB08
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
1.7
7.6
161
981
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.3
7.5
517
4013
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
7.5
3075
28906
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.8
7.3
1677
18652
G43.9
ICD-10 Finland
Migraine, unspecified
1.4
7.3
375
2775
M54.6
ICD-10 Finland
Pain in thoracic spine
1.5
7.3
252
1729
M79.7
ICD-10 Finland
Fibromyalgia
1.7
7.3
150
907
N20.1
ICD-10 Finland
Calculus of ureter
2.2
7.3
69
316
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.2
7.2
936
7875
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.7
7.2
148
896
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.4
7.2
364
2687
SPAT1240
SPAT
Therapeutic discussion
1.3
7.2
630
5055
O32.1
ICD-10 Finland
Maternal care for breech presentation
1.4
7.1
323
2340
SGA01
NOMESCO Finland
Tooth opening as first aid
1.3
7.1
677
5487
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.4
7.1
384
2865
M02AA07
ATC
piroxicam; topical
1.2
7.1
837
6965
R01AD12
ATC
fluticasone furoate; nasal
1.2
7.1
1436
12638
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
2.1
7.1
75
360
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
7.0
874
7318
LAC20
NOMESCO Finland
Destruction of lesion of ovary
4.9
7.0
21
43
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
1.2
6.9
1177
10180
8341
FHL
Colony removal or incineration
6.3
6.9
17
27
A03FA01
ATC
metoclopramide; systemic, rectal
1.3
6.9
649
5255
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.2
6.9
864
7239
J01FA06
ATC
roxithromycin; oral
1.2
6.9
1385
12173
A10BD07
ATC
metformin and sitagliptin; systemic
2.5
6.9
49
195
LCH03
NOMESCO Finland
Evacuation of products of conception and curettage of uterus
0.4
6.9
22
591
6266A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Metrorrhagia
2.9
6.9
38
131
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.2
6.9
872
7315
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
6.8
502
3933
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
6.8
2282
20970
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.4
6.8
377
2826
R09
ICPC
Sinus symptom/complaint
1.4
6.8
399
3018
L68.9
ICD-10 Finland
Hypertrichosis, unspecified
8.3
6.8
14
17
Z64.0
ICD-10 Finland
Problems related to unwanted pregnancy
0.6
6.8
87
1480
160
Kela drug reimbursment
exenatide
3.1
6.8
35
115
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.2
6.8
1194
10362
SPAT1357
SPAT
Monitoring of problem during pregnancy
1.5
6.8
253
1764
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
1.9
6.8
95
511
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
6.1
6.8
17
28
LAA01
NOMESCO Finland
Laparoscopic puncture of ovarian cyst
5.6
6.7
18
32
M25.5
ICD-10 Finland
Pain in joint
1.2
6.7
1030
8811
8215
FHL
Microsurgical tube surgery
16.7
6.7
10
6
R06.0
ICD-10 Finland
Dyspnoea
1.3
6.7
602
4845
D07AC01
ATC
betamethasone; topical
1.2
6.7
1048
8986
LCA10
NOMESCO Finland
Curettage of body of uterus
1.8
6.6
99
542
C09CA01
ATC
losartan; oral
1.4
6.6
298
2156
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.5
6.6
188
1239
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
6.6
512
4043
A10BX07
ATC
[U] liraglutide; parenteral
3.9
6.6
25
65
K04.0
ICD-10 Finland
Pulpitis
1.3
6.5
458
3563
O26.82
ICD-10 Finland
Exhaustion and fatigue pregnancy-related
1.6
6.5
175
1138
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.5
6.5
239
1665
WYA40
NOMESCO Finland
Assessment of oral health and treatment needs for family expecting first child
1.6
6.5
171
1108
G03HA01
ATC
cyproterone; systemic
5.7
6.4
17
30
WX110
NOMESCO Finland
Local anesthesy
1.2
6.4
3005
28337
E66.1
ICD-10 Finland
Drug-induced obesity
4.2
6.4
22
52
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
1.5
6.4
200
1346
N06AX16
ATC
venlafaxine; oral
1.3
6.3
578
4661
SPAT1104
SPAT
Monitoring of emergency patient
1.6
6.3
152
960
C10AA07
ATC
rosuvastatin; oral
1.4
6.3
254
1803
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.2
6.3
1267
11123
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
6.3
83
439
E03.89
ICD-10 Finland
Other specified hypothyroidism
1.8
6.3
98
545
ULB02
NOMESCO Finland
Falloposcopy
18.0
6.3
9
5
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
2.8
6.3
37
133
SPAT1100
SPAT
Long-term monitoring of blood pressure
2.0
6.2
74
377
2180A
ICD-9 Finland
Uterine leiomyoma, Submucous leiomyoma of uterus
2.7
6.2
40
150
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.2
6.2
29
90
Z01.2
ICD-10 Finland
Dental examination
1.2
6.2
1792
16231
L02AB02
ATC
medroxyprogesterone; systemic (progestogens)
3.8
6.2
24
64
J01FA10
ATC
azithromycin; systemic
1.2
6.1
2654
24812
SPAT1200
SPAT
Guidance for breast-feeding and breast care
1.4
6.1
256
1829
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.5
6.1
205
1403
JN3AD
NOMESCO Finland
Abdominal CT examination
1.6
6.1
150
955
QBJ30
NOMESCO Finland
Correction of abdominal apron
2.4
6.1
50
214
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
1.5
6.1
170
1116
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
0.8
6.1
785
9222
W03
ICPC
Antepartum bleeding
2.0
6.1
73
373
O30.1
ICD-10 Finland
Triplet pregnancy
6.7
6.0
14
21
R4190
NOMESCO Finland
Nutritional therapy
1.8
6.0
102
587
Z39.1
ICD-10 Finland
Care and examination of lactating mother
1.5
6.0
178
1185

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1262
3930
3.94
307.65
1.5
1.3
262.16
296.31
mu/l
4.35
1143
3453
788
827
11.09
307.65
1.3
1.3
1.49
1.49
nmol/l
0.00
693
680
527
438
13.30
307.65
1.2
1.1
6.67
6.07
umol/l
2.22
503
409
1192
2022
7.39
307.65
1.3
1.2
9.58
9.92
u/l
0.31
1023
1695
264
127
21.87
307.65
1.1
1.0
7.06
4.99
nmol/l
8.29
259
119
1067
2341
5.50
307.65
1.2
1.2
6.63
2.80
ug/l
24.82
1039
2220
491
988
5.39
232.92
1.5
1.4
30.41
32.26
nmol/l
0.59
452
921
629
1645
4.22
215.82
2.0
1.4
0.58
0.52
nmol/l
0.34
548
1373
1225
5010
2.90
206.65
1.3
1.3
10.59
22.43
iu/l
52.74
1056
4346
206
173
12.37
205.79
1.3
1.1
—
—
—
0
0
510
1234
4.48
193.09
1.6
1.4
—
—
—
0
0
193
167
11.97
189.08
1.3
1.2
20.49
14.61
pmol/l
6.79
181
150
144
75
19.73
185.54
1.1
1.1
—
—
—
0
0
520
1455
3.87
160.89
1.4
1.3
9.00
20.22
u/l
27.99
467
1198
236
407
6.03
131.06
2.4
3.7
29.66
28.33
mu/l
0.17
231
386
1113
5369
2.37
126.94
1.5
1.5
—
—
—
0
0
1437
8668
1.92
86.44
1.6
1.6
—
—
—
0
0
1186
7115
1.87
70.31
2.8
2.2
5287.39
6437.67
u/l
0.95
633
2946
4613
41368
2.20
60.45
5.9
4.8
2.23
1.86
mu/l
0.28
4463
39519
4246
37014
1.88
60.14
5.1
4.3
14.27
14.17
pmol/l
2.45
4047
34794
2327
17650
1.59
54.50
2.0
1.8
—
—
—
0
0
353
1528
2.41
48.88
1.3
1.3
—
—
—
0
0
3763
32398
1.62
47.38
4.6
3.5
37.24
36.43
mmol/mol
8.01
3630
30783
2757
22217
1.52
46.06
4.3
3.9
—
—
—
0
0
1240
8361
1.64
45.65
2.4
2.2
—
—
—
0
0
4204
37406
1.70
44.49
3.6
3.0
5.59
5.47
mmol/l
9.10
3987
35308
897
5598
1.73
44.10
3.2
3.5
618.06
364.55
mg/l
0.66
609
3635
921
5810
1.71
43.48
4.0
4.2
10.93
13.30
mg/mmol
0.79
620
3856
2566
20551
1.50
42.84
4.1
3.5
6.23
6.09
mmol/l
2.86
2232
17790
2065
15998
1.49
39.50
1.7
1.7
—
—
—
0
0
3511
30483
1.49
35.80
4.4
3.8
796.98
1364.29
e6/l
0.79
43
300
1067
7404
1.56
33.28
1.5
1.5
—
—
—
0
0
2707
22558
1.43
32.93
3.5
3.1
0.00
0.00
estimate
0.12
606
4735
2677
22329
1.42
31.99
3.5
3.0
0.00
0.00
estimate
1.15
607
4634
2675
22421
1.41
30.42
4.5
4.2
0.00
0.00
estimate
0.52
621
4815
1561
11927
1.44
29.82
3.8
3.2
0.01
0.00
estimate
0.42
609
4748
83
211
3.98
29.10
1.1
1.2
—
—
—
0
0
2257
18483
1.40
28.82
2.0
1.9
—
—
—
0
0
3526
31175
1.42
28.44
4.4
3.8
—
—
—
0
0
607
3807
1.67
28.36
1.7
1.7
367.65
389.23
nmol/l
2.11
568
3497
1288
9618
1.45
27.35
4.1
4.0
1.02
1.04
inr
1.29
484
3520
2498
20962
1.38
26.74
2.3
2.1
—
—
—
0
0
1412
10788
1.43
26.30
2.4
2.3
54.97
55.27
u/l
0.04
1318
10011
1550
12063
1.41
25.93
2.5
2.1
—
—
—
0
0
4295
39729
1.51
24.78
9.1
7.6
139.33
139.39
mmol/l
1.25
4177
38503
2072
17012
1.37
24.76
4.3
4.5
9.29
9.22
umol/l
0.12
1941
15876
4303
39831
1.51
24.61
9.2
7.6
3.89
3.87
mmol/l
2.85
4174
38468
1095
8083
1.45
24.28
3.3
3.2
8.20
7.87
mmol/l
1.25
957
7091
771
5381
1.51
22.50
1.3
1.2
115.97
155.24
iu/ml
2.24
290
2148
1609
12851
1.37
22.25
3.9
3.9
36.61
37.17
g/l
4.21
1509
11978
1294
10015
1.39
21.59
2.2
2.0
2.74
2.57
mg/l
2.38
1147
8606
1235
9496
1.40
21.39
2.4
2.2
17.96
23.18
ng/l
0.71
417
3002
3045
26854
1.33
21.12
3.3
3.0
54.95
55.82
ug/l
0.21
2900
25622
1672
13582
1.34
20.26
1.9
1.8
—
—
—
0
0
1229
9601
1.37
18.95
1.9
1.7
0.80
0.85
mg/l
0.42
944
6907
1211
9462
1.37
18.60
3.5
3.1
1.02
1.02
kg/l
0.64
216
1438
370
2271
1.68
18.54
2.2
2.3
4.30
4.87
umol/l
1.17
272
1657
59
166
3.58
18.02
1.7
1.5
125.44
126.54
nmol/l
0.08
59
166
1010
7721
1.38
17.64
2.0
2.0
1375.24
2230.25
umol/l
0.64
932
6944
1604
13165
1.32
17.47
1.3
1.3
1.27
1.56
u/ml
0.55
570
3839
4580
43541
1.51
17.11
10.4
8.9
17.35
17.95
mg/l
0.72
3765
33104
4831
46519
1.72
16.89
10.8
8.5
—
—
—
0
0
868
6537
1.40
16.46
1.7
1.5
23499097.85
37389763.56
pmol/l
0.42
766
5761
3050
27376
1.28
16.18
5.9
5.9
70.82
68.98
u/l
2.58
2873
25786
794
5908
1.41
16.14
1.4
1.4
—
—
—
0
0
1255
10064
1.33
15.81
1.9
1.8
—
—
—
0
0
4180
39285
1.35
14.96
3.6
3.1
2.87
2.86
mmol/l
0.42
3996
37359
4138
38840
1.35
14.87
3.4
2.9
1.45
1.54
mmol/l
38.70
3977
37184
3978
37170
1.32
14.42
3.2
2.7
1.29
1.13
mmol/l
31.22
3822
35613
4152
39035
1.34
14.41
3.5
3.0
4.72
4.76
mmol/l
1.88
3994
37405
1225
9901
1.31
14.37
3.4
3.0
—
—
—
0
0
1960
16876
1.26
13.81
2.4
2.2
71.85
72.45
nmol/l
0.50
1855
15922
462
3194
1.49
13.81
2.0
2.2
24.38
31.25
u/ml
2.27
446
3090
893
6962
1.34
13.36
2.4
2.3
—
—
—
0
0
835
6496
1.34
12.61
1.5
1.4
21.19
20.73
nmol/l
0.45
756
5855
58
203
2.88
12.50
1.3
1.4
0.78
2.15
nmol/l
1.41
48
154
538
3908
1.42
12.37
2.3
2.3
310.88
398.40
ng/l
0.74
417
3046
593
4406
1.39
11.95
1.9
1.6
1264.75
1174.67
nmol/l
1.75
492
3472
416
2915
1.47
11.60
3.8
4.8
1.06
1.04
mmol/l
0.99
399
2743
581
4341
1.38
11.30
3.7
3.0
—
—
—
0
0
189
1108
1.73
11.28
6.1
5.7
24.13
24.01
mmol/l
0.19
176
1030
816
6443
1.32
11.00
3.4
3.3
—
—
—
0
0
4547
43704
1.37
10.88
10.0
8.6
64.28
64.69
umol/l
0.85
4547
43680
601
4564
1.36
10.54
1.7
1.6
—
—
—
0
0
1632
14081
1.23
10.50
5.0
4.6
1.21
1.22
mmol/l
0.71
1361
11886
1442
12314
1.24
10.15
1.9
1.6
98.53
99.16
pmol/l
0.20
860
6960
108
550
1.98
10.11
2.3
2.9
0.94
0.83
nmol/l
0.76
90
468
471
3470
1.39
9.95
3.2
2.7
31.25
33.17
%
3.50
387
2676
543
4107
1.36
9.75
2.8
2.9
0.83
0.83
mmol/l
0.07
520
3849
4605
44477
1.36
9.57
8.3
7.4
25.94
23.00
u/l
15.64
4474
43217
5019
49374
2.02
9.42
16.1
13.6
89.24
89.73
fl
14.08
4997
48981
5021
49401
2.03
9.41
16.3
13.7
133.06
132.61
g/l
2.29
4998
49004
5020
49391
2.02
9.35
16.2
13.7
7.13
6.83
e9/l
16.72
4950
48466
5019
49379
2.01
9.33
16.2
13.6
4.50
4.45
e12/l
15.48
4955
48490
1552
13473
1.22
9.12
3.1
2.6
—
—
—
0
0
5017
49372
1.97
9.02
16.1
13.5
29.72
29.91
pg
13.86
4995
48978
342
2426
1.44
8.96
3.1
3.1
—
—
—
0
0
5013
49328
1.93
8.88
16.2
13.6
272.15
269.51
e9/l
2.52
4950
48480
3214
29907
1.20
8.83
3.8
3.5
9.39
8.64
mm/h
4.49
3031
28154
2489
22659
1.19
8.63
2.6
2.4
—
—
—
0
0
128
727
1.78
8.62
1.1
1.1
23.68
13339.60
iu/ml
0.64
39
201
650
5137
1.30
8.59
2.0
2.1
14.18
14.93
umol/l
1.93
590
4780
380
2777
1.40
8.43
1.1
1.2
—
—
—
0
0
86
434
2.00
8.33
1.1
1.1
1.03
1.05
ratio
1.10
34
163
70
330
2.14
8.14
1.0
1.0
—
—
—
0
0
143
856
1.69
8.02
1.6
1.5
9.22
11.15
mmol/l
—
9
68
491
3777
1.33
7.87
1.4
1.4
—
—
—
0
0
176
1122
1.59
7.71
8.1
6.5
—
—
—
0
0
1428
12459
1.20
7.71
4.6
4.1
1.21
1.22
mmol/l
0.75
1308
11385
1530
13461
1.20
7.50
2.9
2.8
28.03
27.13
u/l
0.48
1454
12889
1263
10919
1.21
7.48
1.4
1.4
2.07
2.03
g/l
0.60
826
7094
102
568
1.81
7.39
2.0
1.8
2.71
1.42
ug/l
0.31
90
503
316
2297
1.40
7.26
2.3
2.2
0.23
0.23
g/l
0.35
294
2164
188
1241
1.53
7.10
2.3
2.6
5.07
5.03
kpa
0.32
171
1163
186
1225
1.54
7.10
2.3
2.6
7.41
7.42
ph
0.09
25
190
267
1904
1.42
6.85
1.6
1.6
—
—
—
0
0
1012
8654
1.21
6.61
1.3
1.3
22.76
23.24
iu/ml
0.04
301
2564
118
710
1.68
6.57
3.7
4.3
—
—
—
0
0
28
95
2.96
6.52
1.8
2.9
7.43
7.44
ph
—
9
17
919
7809
1.22
6.39
2.0
1.9
201.68
127.36
u/l
0.52
875
7414
808
6779
1.23
6.37
1.4
1.4
515.56
609.61
titre
0.87
135
1319
121
740
1.65
6.34
2.2
2.5
24.62
24.32
mmol/l
0.72
112
697
1209
10551
1.19
6.31
2.3
2.7
2.33
2.34
mmol/l
1.54
1092
9558
604
4917
1.26
6.26
1.5
1.5
—
—
—
0
0
1868
16914
1.16
6.20
2.2
2.0
—
—
—
0
0
589
4790
1.26
6.16
1.5
1.5
—
—
—
0
0
589
4797
1.26
6.08
1.5
1.5
—
—
—
0
0
241
1726
1.42
6.07
7.4
6.4
97.06
96.59
%
1.05
230
1649
78
428
1.84
6.00
2.5
2.8
37.02
136.79
ug/min
2.75
50
306
231
1647
1.42
5.97
1.8
1.6
7.58
7.47
mmol/l
0.26
142
1001
338
2570
1.34
5.90
2.9
2.8
—
—
—
0
0
92
534
1.74
5.88
3.3
3.8
3.73
3.74
mmol/l
0.07
86
497
161
1076
1.51
5.81
4.9
4.1
—
—
—
0
0
127
807
1.59
5.74
2.2
2.6
—
—
—
0
0
560
4575
1.25
5.63
1.9
2.1
2.59
2.53
g/l
1.98
514
4223
562
4595
1.25
5.61
1.1
1.1
—
—
—
0
0
66
352
1.89
5.58
1.3
1.1
2.50
14.36
u/ml
—
8
36
958
8278
1.19
5.52
1.3
1.3
6.52
7.75
u/ml
0.40
471
3535
282
2111
1.36
5.47
1.3
1.3
0.29
1.07
u/ml
2.41
28
166
548
4482
1.25
5.45
1.7
1.7
—
—
—
0
0
18
52
3.47
5.44
1.9
2.6
—
—
—
0
0
229
1659
1.40
5.44
7.6
6.6
127.09
120.87
g/l
5.68
222
1596
101
618
1.65
5.35
2.4
2.2
—
—
—
0
0
1517
13639
1.16
5.35
3.1
3.0
64.19
62.52
e6/l
0.04
943
8385
133
873
1.54
5.25
1.2
1.2
—
—
—
0
0
223
1620
1.39
5.22
1.9
1.9
20.23
20.54
s
0.66
168
1324
956
8298
1.19
5.21
1.6
1.5
1.47
1.28
mmol/l
4.76
827
7359
461
3719
1.26
5.17
3.3
3.4
4.58
4.59
pmol/l
0.09
411
3363
389
3088
1.28
4.99
1.1
1.1
606.67
217.43
titre
—
9
92
1239
11029
1.16
4.92
3.7
3.8
—
—
—
0
0
126
833
1.53
4.85
1.1
1.1
116.82
117.12
%
0.04
119
753
96
596
1.62
4.84
1.3
1.3
—
—
—
0
0
1918
17645
1.14
4.74
1.9
1.9
—
—
—
0
0
389
3111
1.27
4.71
2.0
1.9
4.12
4.19
e9/l
0.27
327
2671
22
79
2.79
4.70
1.1
1.1
—
—
—
0
0
288
2224
1.31
4.57
2.4
2.8
1.22
1.23
mmol/l
1.59
253
1911
130
879
1.49
4.52
1.3
1.2
2.73
3.93
u/ml
1.45
52
364
279
2154
1.31
4.45
1.4
1.3
—
—
—
0
0
486
4015
1.23
4.43
2.0
2.2
22.88
24.34
%
1.59
399
3476
821
7134
1.18
4.38
2.4
2.2
9.18
9.63
e6/l
0.32
719
6102
13
35
3.72
4.36
1.3
1.4
—
—
—
0
0
33
150
2.21
4.36
3.1
3.0
—
—
—
0
0
464
3832
1.23
4.25
2.4
2.3
5.59
5.19
umol/l
0.36
382
3164
318
2516
1.28
4.22
5.9
5.6
105.31
105.17
mmol/l
0.25
310
2470
188
1380
1.38
4.21
2.2
2.3
3.79
3.59
g/l
1.18
182
1280
243
1858
1.32
4.17
1.1
1.1
1.55
4.23
u/ml
2.97
32
309
377
3051
1.25
4.16
1.2
1.2
—
—
—
0
0
263
2046
1.30
4.00
7.0
6.0
0.93
0.52
mmol/l
1.04
180
1478
86
547
1.58
3.99
1.3
1.3
—
—
—
0
0
85
542
1.58
3.91
2.2
2.4
—
—
—
0
0
2474
23337
1.12
3.74
6.6
7.7
4.12
3.98
e9/l
2.63
2217
20668
541
4598
1.20
3.72
1.2
1.2
—
—
—
0
0
2180
20427
1.12
3.70
5.0
5.5
0.52
0.52
e9/l
0.15
1974
18237
2188
20511
1.12
3.68
5.0
5.5
0.04
0.04
e9/l
0.95
1973
18251
27
122
2.22
3.66
1.7
2.5
625.24
614.61
ml
0.04
21
98
159
1165
1.38
3.65
1.8
1.6
6.78
6.50
mmol/l
0.62
101
817
2267
21308
1.12
3.61
5.1
5.7
0.19
0.18
e9/l
1.69
2090
19299
333
2704
1.25
3.60
2.9
2.5
—
—
—
0
0
485
4098
1.20
3.56
1.8
2.0
28.77
29.04
s
0.63
473
3932
165
1225
1.36
3.50
1.4
1.6
11.96
6.26
u/ml
—
5
38
15
52
2.89
3.46
1.1
1.1
9.18
8.59
pmol/l
—
10
27
2278
21453
1.11
3.45
4.9
5.4
2.06
1.99
e9/l
3.95
2094
19528
41
222
1.85
3.44
1.0
1.1
—
—
—
0
0
257
2038
1.27
3.41
7.2
6.0
13.36
14.32
kpa
2.04
247
1947
257
2038
1.27
3.41
7.2
6.0
4.96
4.95
kpa
0.08
247
1946
17
65
2.62
3.30
1.4
1.1
—
—
—
0
0
162
1214
1.35
3.26
1.8
1.8
3.23
4.21
ug/l
0.77
140
1059
97
665
1.47
3.26
1.3
1.4
—
—
—
0
0
928
8317
1.14
3.24
3.2
3.2
7.39
7.40
ph
0.19
201
1596
356
2949
1.22
3.22
2.1
2.3
10.45
10.52
g/l
0.13
325
2735
88
593
1.49
3.22
1.8
2.3
—
—
—
0
0
136
997
1.37
3.16
2.5
2.7
—
—
—
0
0
82
550
1.50
3.09
2.6
3.1
—
—
—
0
0
140
1039
1.36
3.03
1.2
1.3
62.50
126.39
titre
1.67
12
108
59
369
1.61
3.02
1.5
1.3
—
—
—
0
0
68
440
1.55
3.02
1.2
1.1
—
—
—
0
0
134
988
1.37
3.02
2.4
2.1
1.17
1.21
g/l
0.23
120
866
106
754
1.41
2.96
5.2
3.9
1.22
1.13
mmol/l
0.74
92
666
140
1044
1.35
2.95
2.2
2.8
0.39
0.32
g/l
0.44
65
424
70
459
1.53
2.94
1.6
1.4
—
—
—
0
0
553
4810
1.17
2.93
1.9
2.2
2.40
2.40
mmol/l
0.01
475
4152
148
1115
1.34
2.92
1.2
1.2
—
—
—
0
0
1041
9468
1.12
2.87
2.5
2.4
—
—
—
0
0
16
64
2.50
2.86
1.4
1.1
—
—
—
0
0
142
1067
1.34
2.85
1.2
1.3
100.55
106.83
u/ml
0.34
29
262
13
47
2.77
2.81
1.1
1.1
—
—
—
0
0
38
216
1.76
2.79
2.5
2.1
—
—
—
0
0
120
882
1.37
2.79
1.3
1.3
—
—
—
0
0
271
2219
1.23
2.78
1.8
1.8
1.27
1.38
g/l
1.17
249
2083
1119
10244
1.12
2.75
2.7
2.6
41.76
78.68
e6/l
1.26
840
7496
93
657
1.42
2.73
2.2
2.5
7.42
7.42
ph
0.14
79
556
327
2736
1.21
2.72
1.1
1.1
—
—
—
0
0
8
19
4.22
2.67
1.0
1.2
—
—
—
0
0
355
3002
1.20
2.65
1.3
1.2
—
—
—
0
0
36
205
1.76
2.64
3.0
2.4
—
—
—
0
0
81
563
1.45
2.61
2.3
2.4
1.72
1.91
mmol/l
0.44
48
302
150
1155
1.31
2.58
2.4
2.1
13.17
13.08
%
0.50
150
1141
287
2385
1.22
2.58
1.2
1.2
—
—
—
0
0
17
74
2.30
2.57
1.9
2.8
—
—
—
0
0
6
11
5.46
2.54
1.0
1.1
—
—
—
0
0
40
238
1.69
2.53
2.5
2.1
—
—
—
0
0
48
302
1.60
2.46
1.7
1.4
—
—
—
0
0
165
1296
1.28
2.46
1.3
1.3
15.69
9.99
u/ml
0.28
24
224
100
732
1.37
2.43
5.4
3.9
1.80
1.81
%
0.02
94
681
1014
9307
1.11
2.36
2.6
2.5
0.16
0.26
e6/l
3.28
758
6716
139
1076
1.30
2.33
8.8
7.6
1.43
1.40
%
0.12
139
1068
161
1272
1.27
2.31
1.4
1.3
3.79
7.77
u/ml
0.60
13
143
39
238
1.64
2.28
1.2
1.1
—
—
—
0
0
144
1125
1.29
2.26
1.2
1.3
—
—
—
0
0
36
216
1.67
2.24
1.1
1.2
—
—
—
0
0
13
54
2.41
2.19
1.2
1.2
—
—
—
0
0
179
1444
1.25
2.18
1.3
1.3
38.63
36.78
u/ml
0.03
15
118
42
267
1.58
2.11
1.4
1.2
10.37
23.64
u/l
1.74
34
232
62
429
1.45
2.11
1.3
1.2
—
—
—
0
0
206
1696
1.22
2.09
2.9
3.2
85.01
72.01
ng/l
0.34
180
1542
98
736
1.34
2.07
5.5
3.9
0.95
0.93
%
0.15
93
688
232
1935
1.21
2.07
1.6
1.7
—
—
—
0
0
184
1505
1.23
2.00
2.4
2.4
—
—
—
0
0
512
4565
1.14
1.98
2.7
2.5
376.61
297.17
ng/l
0.14
204
1846
56
387
1.45
1.94
1.6
1.4
476.83
423.35
pmol/l
0.27
47
306
37
236
1.57
1.86
2.4
1.4
286.30
285.83
mosm/kgh2o
0.07
30
189
20
356
0.56
1.86
1.2
2.8
—
—
—
0
0
56
392
1.43
1.83
1.4
1.4
51.63
42.45
mu/l
0.15
50
356
98
752
1.31
1.82
1.1
1.1
—
—
—
0
0
464
4136
1.13
1.82
1.5
1.4
—
—
—
0
0
59
418
1.42
1.81
7.5
5.2
11.44
11.01
mmol/l
0.54
54
374
132
1641
0.80
1.79
1.5
1.8
—
—
—
0
0
59
419
1.41
1.79
7.5
5.2
105.91
105.97
mmol/l
0.04
54
375
67
487
1.38
1.78
2.3
2.0
17.10
17.20
%
0.07
33
233
174
1437
1.22
1.76
1.6
1.9
68.04
67.93
g/l
0.08
164
1341
155
1266
1.23
1.75
2.1
2.1
—
—
—
0
0
27
162
1.67
1.74
2.9
2.0
—
—
—
0
0
135
1088
1.25
1.72
9.0
7.6
0.77
0.72
%
0.95
135
1081
145
1179
1.24
1.71
2.3
2.2
64.59
70.89
ng/l
0.21
130
1026
3977
39039
1.08
1.66
11.8
10.8
13.41
13.36
%
0.80
3899
38360
798
7373
1.10
1.64
2.5
2.5
96.61
92.07
ug/g
0.20
602
5718
90
696
1.30
1.62
1.0
1.1
—
—
—
0
0
5
14
3.57
1.61
1.0
1.1
—
—
—
0
0
707
6505
1.10
1.59
2.4
2.3
548.57
534.08
mosm/kgh2o
0.84
607
5468
430
3857
1.13
1.55
1.3
1.3
—
—
—
0
0
1939
18594
1.07
1.55
7.7
7.2
0.00
0.00
e9/l
0.06
1647
15377
23
137
1.68
1.55
1.6
1.4
—
5.93
—
0
16
127
1032
1.24
1.54
1.4
1.7
—
—
—
0
0
5
15
3.34
1.52
1.0
1.1
—
—
—
0
0
675
7322
0.91
1.52
1.3
1.2
—
—
—
0
0
2007
19279
1.07
1.51
4.9
5.4
2.69
2.72
%
0.29
1878
18050
11
51
2.16
1.50
2.3
1.9
1.35
1.26
umol/l
0.89
11
42
40
275
1.46
1.48
1.0
1.1
4.84
5.66
u/ml
—
6
44
52
376
1.39
1.47
1.5
1.6
5.13
5.62
mmol/l
1.79
45
325
34
227
1.50
1.46
2.9
2.9
—
—
—
0
0
94
744
1.27
1.44
3.5
3.2
21.60
22.93
mg/l
0.12
60
432
5
16
3.13
1.44
1.0
1.3
—
—
—
0
0
5
16
3.13
1.44
1.2
1.1
64.02
106.20
nmol/24h
—
5
16
57
422
1.35
1.41
2.8
2.7
1.54
1.35
e9/l
0.59
27
247
74
570
1.30
1.41
3.8
4.2
76.90
94.03
u/ml
0.13
25
190
46
330
1.40
1.38
2.8
2.7
0.23
0.21
e9/l
0.39
38
284
15
82
1.83
1.35
1.1
1.6
—
—
—
0
0
47
341
1.38
1.33
1.9
2.6
1.95
1.38
%
0.28
38
260
47
341
1.38
1.33
1.1
1.2
—
—
—
0
0
51
376
1.36
1.32
1.3
1.2
—
—
—
0
0
45
613
0.73
1.29
1.6
1.5
—
—
—
0
0
2012
19411
1.06
1.27
5.2
5.6
7.40
7.71
%
5.68
1906
18348
173
1480
1.17
1.27
2.6
2.2
0.18
0.25
e6/l
0.66
162
1399
50
370
1.35
1.27
1.1
1.1
1411.62
1499.69
miu/ml
0.22
50
370
46
336
1.37
1.26
2.8
2.7
622.59
519.31
e6/l
1.16
37
284
49
362
1.36
1.26
2.6
2.3
—
—
—
0
0
61
466
1.31
1.26
1.2
1.2
—
—
—
0
0
118
977
1.21
1.25
2.0
2.0
9.39
9.90
mg/l
0.35
108
935
8
36
2.22
1.24
1.6
2.3
—
—
—
0
0
13
70
1.86
1.23
1.5
2.0
1.15
1.42
mg/l
0.34
13
64
9
45
2.00
1.23
1.8
2.8
—
20.79
—
0
10
9
45
2.00
1.23
1.8
1.6
41.58
33.11
%
—
9
40
76
955
0.79
1.22
2.0
2.3
—
—
—
0
0
71
557
1.28
1.21
1.0
1.1
199.28
198.37
mg/l
0.02
63
491
16
93
1.72
1.21
1.1
1.6
37.98
35.54
g/l
0.24
16
88
136
1146
1.19
1.20
1.2
1.3
468.33
416.84
mg/l
0.25
129
1092
6
26
2.31
1.18
2.2
1.5
275.00
311.19
umol/24h
—
6
26
8
39
2.05
1.15
1.4
1.0
—
—
—
0
0
5
20
2.50
1.15
1.4
1.2
—
—
—
0
0
72
901
0.80
1.14
13.4
7.8
23.95
23.89
mmol/l
0.06
66
861
23
150
1.54
1.14
1.6
1.4
—
—
—
0
0
382
4193
0.90
1.14
1.2
1.3
—
—
—
0
0
318
2865
1.12
1.13
3.5
4.1
0.58
0.81
%
0.96
71
569
5
113
0.44
1.12
1.0
1.2
—
—
—
0
0
120
1008
1.20
1.12
1.3
1.4
166.52
5390.92
e6/l
0.81
100
826
72
573
1.26
1.12
1.1
1.2
35.59
35.74
mg/l
0.01
60
476
120
1009
1.19
1.11
1.2
1.3
5.89
19.92
e6/l
2.84
95
789
67
530
1.27
1.10
2.9
2.7
23.27
23.78
mmol/l
0.46
58
476
45
337
1.34
1.09
11.1
4.3
9.34
6.44
mmol/l
0.48
39
274
7
138
0.51
1.09
1.1
1.3
—
—
—
0
0
3142
30782
1.05
1.07
2.8
2.6
32.83
28.61
u/l
5.13
3021
29622
295
2658
1.12
1.06
3.4
3.9
0.57
0.55
%
0.03
53
423
2108
20448
1.05
1.06
4.9
5.3
30.30
30.15
%
0.30
1981
19285
20
129
1.55
1.05
1.3
1.3
—
—
—
0
0
5
22
2.27
1.03
1.6
1.2
596.16
487.99
nmol/l
—
5
22
2081
20192
1.05
1.02
4.8
5.2
56.51
56.45
%
0.09
1962
19102
245
2190
1.12
1.02
8.4
8.0
1.07
1.08
inr
0.06
47
418
9
47
1.92
1.02
1.0
1.1
—
—
—
0
0
24
346
0.69
1.01
16.2
13.5
853.79
849.86
nmol/l
0.01
24
334
335
3675
0.91
1.01
1.8
2.0
—
—
—
0
0
74
600
1.24
1.00
2.7
2.0
131.77
132.08
g/l
0.05
65
461
15
91
1.65
1.00
1.0
1.1
—
—
—
0
0
26
180
1.45
1.00
1.4
1.5
2882.44
54937.46
e6/l
0.81
18
123
113
957
1.18
0.99
1.4
1.3
—
—
—
0
0
119
1013
1.18
0.99
1.2
1.2
3.53
3.51
mmol/l
0.06
112
951
9
49
1.84
0.98
1.1
1.2
—
—
—
0
0
166
1451
1.15
0.98
1.2
1.2
—
—
—
0
0
179
1574
1.14
0.97
1.8
2.0
1.19
1.15
g/l
0.88
171
1507
42
318
1.32
0.97
1.0
1.1
—
—
—
0
0
15
92
1.63
0.97
1.9
2.3
21.07
24.07
ug/l
0.17
15
92
17
108
1.58
0.96
4.8
2.8
59.96
108.83
ng/l
0.64
12
68
29
207
1.40
0.96
1.7
2.3
58.85
53.70
%
0.59
20
126
114
972
1.18
0.94
11.0
7.2
—
—
—
0
0
138
1195
1.16
0.94
1.3
1.3
20.64
37.19
u/ml
1.09
14
115
101
1190
0.85
0.92
1.3
1.3
—
—
—
0
0
11
183
0.60
0.90
1.0
1.4
—
—
—
0
0
18
118
1.53
0.90
1.3
1.8
—
—
—
0
0
406
3755
1.09
0.90
1.3
1.3
150.41
209.73
u/ml
0.80
381
3492
373
4043
0.92
0.89
1.8
1.9
—
—
—
0
0
95
802
1.19
0.89
1.3
1.3
353.70
331.02
ug/g
0.40
44
375
367
3979
0.92
0.89
1.8
1.9
—
—
—
0
0
8
42
1.91
0.88
1.4
3.3
—
—
—
0
0
173
1532
1.13
0.87
1.9
2.1
0.23
0.22
g/l
0.78
166
1462
56
449
1.25
0.87
1.1
1.1
1.37
1.46
g/l
1.01
50
410
371
4012
0.92
0.85
1.8
1.9
—
—
—
0
0
51
406
1.26
0.84
1.6
1.8
—
—
—
0
0
38
291
1.31
0.84
3.4
2.9
993.91
877.41
e6/l
0.35
22
134
373
4029
0.92
0.84
1.8
1.9
—
—
—
0
0
76
633
1.20
0.83
2.5
2.1
133.87
252.75
ug/l
0.99
58
544
111
956
1.16
0.83
2.1
1.8
—
—
—
0
0
30
222
1.35
0.83
1.3
1.5
4.40
5.38
u/l
0.99
25
185
6
32
1.88
0.81
1.2
1.0
—
—
—
0
0
12
73
1.65
0.81
1.2
1.7
—
—
—
0
0
13
81
1.61
0.81
1.0
1.0
—
—
—
0
0
0
27
0.00
0.77
0.0
1.2
—
—
—
0
0
290
2667
1.09
0.76
3.7
4.2
0.00
0.21
%
0.64
58
451
202
1825
1.11
0.76
6.3
5.4
1.30
1.25
mmol/l
0.39
195
1759
50
404
1.24
0.75
1.1
1.2
0.74
0.31
u/ml
0.32
20
126
37
288
1.29
0.75
3.8
3.8
53.60
33.80
u/ml
0.26
37
288
28
210
1.34
0.73
1.5
1.7
41.75
44.59
%
0.15
20
117
7
38
1.84
0.73
1.0
1.0
—
—
—
0
0
35
272
1.29
0.72
1.3
1.2
—
—
—
0
0
14
92
1.52
0.72
1.0
1.0
0.03
0.14
u/ml
—
6
48
14
92
1.52
0.72
1.1
1.5
41796.43
4222.62
e6/l
—
7
66
120
1362
0.88
0.72
1.0
1.1
—
—
—
0
0
11
68
1.62
0.71
1.5
1.3
—
—
—
0
0
7
40
1.75
0.71
1.9
1.9
—
—
—
0
0
1902
18551
1.04
0.70
5.1
5.5
0.65
0.67
%
1.07
1781
17361
170
1530
1.11
0.70
2.3
2.3
73.54
70.99
e9/l
0.48
129
1075
7
41
1.71
0.70
1.6
1.9
—
—
—
0
0
156
1738
0.89
0.69
2.3
2.5
—
—
—
0
0
13
85
1.53
0.68
3.6
5.1
—
—
—
0
0
5
27
1.85
0.68
1.2
1.1
—
—
—
0
0
112
985
1.14
0.67
1.1
1.1
—
—
—
0
0
5
28
1.79
0.66
1.4
1.7
—
—
—
0
0
183
1661
1.11
0.66
5.4
6.4
5.98
6.24
mmol/l
0.38
177
1607
20
145
1.38
0.65
1.1
1.2
—
—
—
0
0
1302
12621
1.04
0.65
5.1
5.6
—
—
—
0
0
7
44
1.59
0.65
1.1
1.1
—
—
—
0
0
15
103
1.46
0.64
1.1
1.1
—
—
—
0
0
5
29
1.72
0.64
1.4
1.8
—
—
—
0
0
5
29
1.72
0.64
1.0
1.2
—
—
—
0
0
472
4990
0.94
0.63
2.3
2.3
5.15
5.26
e6/l
0.06
242
2505
89
1019
0.87
0.63
3.2
3.4
24.19
24.08
mmol/l
0.13
76
907
10
63
1.59
0.61
1.2
1.1
—
—
—
0
0
5
30
1.67
0.61
1.8
1.1
15.69
16.95
umol/l
—
5
30
0
20
0.00
0.60
0.0
1.0
—
0.16
—
0
10
40
488
0.82
0.60
1.5
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
2.8
—
—
—
0
0
13
186
0.70
0.59
1.1
1.1
—
—
—
0
0
27
344
0.78
0.59
1.1
1.1
—
—
—
0
0
10
64
1.56
0.58
1.0
1.0
0.15
0.52
u/ml
—
5
31
36
291
1.24
0.58
1.0
1.1
—
—
—
0
0
7
115
0.61
0.57
1.9
1.4
—
—
—
0
0
296
2767
1.07
0.57
3.6
4.2
0.02
0.17
%
1.51
63
532
207
1909
1.09
0.56
1.0
1.1
—
—
—
0
0
8
55
1.46
0.56
1.0
1.5
—
—
—
0
0
30
239
1.26
0.55
1.3
1.4
—
—
—
0
0
49
412
1.19
0.55
2.7
2.6
39.58
31.00
umol/l
0.84
40
355
193
1778
1.09
0.54
3.1
3.3
1.37
1.59
mmol/l
0.39
158
1392
24
186
1.29
0.54
3.1
2.9
36.83
100.60
mg/l
0.91
19
129
32
258
1.24
0.53
1.1
1.2
63.80
70.17
%
—
5
24
345
3252
1.07
0.53
2.3
2.3
12.95
21.93
au/ml
2.12
23
269
39
322
1.21
0.53
1.2
1.4
—
—
—
0
0
39
322
1.21
0.53
1.2
1.4
—
—
—
0
0
39
322
1.21
0.53
1.2
1.4
—
—
—
0
0
39
322
1.21
0.53
1.2
1.4
—
—
—
0
0
6
39
1.54
0.53
1.0
1.1
—
—
—
0
0
9
62
1.45
0.53
1.0
1.0
—
—
—
0
0
13
91
1.43
0.53
1.0
1.0
0.04
0.05
u/ml
—
7
48
53
452
1.17
0.52
1.7
1.4
—
—
—
0
0
448
4704
0.95
0.51
1.7
1.7
—
—
—
0
0
9
65
1.39
0.50
1.2
1.3
—
—
—
0
0
23
180
1.28
0.49
1.7
1.6
2140.00
2339.89
ml
—
5
27
12
84
1.43
0.49
1.3
1.6
—
—
—
0
0
7
45
1.56
0.49
6.4
7.0
—
—
—
0
0
44
373
1.18
0.47
1.1
1.1
—
—
—
0
0
12
85
1.41
0.46
1.0
1.1
—
—
—
0
0
12
85
1.41
0.46
1.0
1.1
—
—
—
0
0
12
85
1.41
0.46
1.0
1.1
—
—
—
0
0
7
48
1.46
0.46
1.0
1.2
—
—
—
0
0
5
82
0.61
0.45
5.8
4.6
—
—
—
0
0
4342
43163
1.04
0.45
10.4
9.8
39.70
39.52
%
1.02
3459
36518
39
460
0.85
0.44
1.0
1.0
—
—
—
0
0
79
706
1.12
0.43
1.4
1.4
—
3640.00
—
0
8
295
3114
0.94
0.43
1.8
2.0
—
—
—
0
0
98
888
1.11
0.42
1.2
1.2
—
—
—
0
0
5
32
1.56
0.42
3.8
2.7
—
—
—
0
0
12
87
1.38
0.42
1.0
1.0
0.28
0.63
u/ml
—
7
49
40
341
1.17
0.42
2.2
2.4
10.78
12.28
%
0.44
23
189
123
1129
1.09
0.41
1.1
1.2
233.06
254.60
u/ml
0.48
72
772
45
388
1.16
0.41
1.1
1.1
7.09
6.68
iu/ml
—
10
107
0
15
0.00
0.41
0.0
1.3
—
5.12
—
0
9
58
510
1.14
0.41
1.5
1.7
11094.09
7628.66
e6/l
0.23
46
375
0
17
0.00
0.40
0.0
2.0
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
0.01
—
0
6
39
333
1.17
0.40
1.9
2.3
43.21
47.52
%
0.59
14
56
319
3035
1.05
0.40
1.3
1.3
25.58
31.42
au/ml
0.20
12
106
111
1211
0.91
0.40
1.0
1.1
—
—
—
0
0
111
1211
0.91
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
4002
40281
0.97
0.39
13.0
11.3
332.23
332.39
g/l
0.57
3980
39962
41
353
1.16
0.39
1.2
1.2
—
—
—
0
0
168
1573
1.07
0.36
2.2
2.2
3.61
4.19
iu/l
0.68
69
690
51
450
1.13
0.36
1.5
1.4
0.33
0.37
g/l
0.86
42
321
51
450
1.13
0.36
1.5
1.4
3.03
3.03
g/l
0.00
42
320
51
451
1.13
0.35
1.5
1.4
6.31
6.55
g/l
0.30
42
323
48
423
1.14
0.35
2.3
2.7
—
—
—
0
0
40
348
1.15
0.34
2.3
2.4
76.15
76.09
%
0.01
40
340
42
367
1.15
0.34
2.4
2.2
1.47
1.25
mmol/l
1.01
42
360
6
44
1.36
0.34
1.5
1.2
81.60
79.46
ng/l
—
6
44
33
283
1.17
0.34
6.9
7.2
—
—
—
0
0
11
82
1.34
0.34
1.5
1.5
—
—
—
0
0
11
82
1.34
0.34
1.0
1.0
—
—
—
0
0
60
539
1.11
0.33
1.5
1.4
—
—
—
0
0
386
3714
1.04
0.33
1.3
1.3
244.57
237.63
miu/ml
0.15
223
1932
6
88
0.68
0.33
1.8
2.0
—
—
—
0
0
35
303
1.16
0.32
1.1
1.1
301.48
307.10
mg/l
0.14
29
277
964
9430
1.03
0.32
1.5
1.5
—
—
—
0
0
20
165
1.21
0.31
2.5
2.4
192.73
190.30
e6/l
0.01
11
99
13
164
0.79
0.30
2.3
3.1
—
—
—
0
0
22
185
1.19
0.29
2.1
1.8
104.59
106.24
mmol/l
0.62
22
185
22
185
1.19
0.29
2.1
1.8
3.70
3.88
mmol/l
1.10
22
185
8
106
0.75
0.29
1.1
1.5
—
—
—
0
0
48
430
1.12
0.29
1.1
1.1
—
0.16
nmol/l
—
0
5
33
288
1.15
0.29
1.0
1.1
15.44
11.62
u/ml
—
8
56
8
110
0.73
0.28
1.6
2.3
—
—
—
0
0
15
121
1.24
0.28
1.3
1.1
—
—
—
0
0
175
1844
0.95
0.28
2.9
3.4
7.81
32.10
ug/l
0.58
121
1223
532
5172
1.03
0.28
1.2
1.2
—
—
—
0
0
37
417
0.89
0.27
1.1
1.2
—
—
—
0
0
201
2107
0.95
0.27
1.6
1.7
—
—
—
0
0
8
66
1.21
0.26
1.1
1.5
—
—
—
0
0
22
257
0.86
0.26
1.3
1.2
—
—
—
0
0
12
95
1.26
0.26
1.8
2.7
—
—
—
0
0
13
160
0.81
0.26
1.0
1.1
4.67
4.75
mg/g
0.05
13
155
90
839
1.07
0.25
1.4
1.4
—
2.30
—
0
10
343
3318
1.04
0.25
2.4
2.2
28.84
35.27
u/l
2.80
288
2836
38
340
1.12
0.24
2.5
2.3
7.34
6.83
mmol/l
0.53
38
335
25
217
1.15
0.24
2.5
2.1
20.18
144.74
ug/l
0.74
25
207
9
77
1.17
0.24
1.1
1.1
—
—
—
0
0
15
124
1.21
0.24
1.1
1.2
—
—
—
0
0
145
1378
1.05
0.23
1.1
1.1
—
—
—
0
0
28
246
1.14
0.23
2.8
3.1
9.58
8.10
mg/l
0.44
23
194
159
1515
1.05
0.23
1.1
1.1
5.39
5.87
u/ml
0.16
72
820
275
2849
0.96
0.23
2.0
2.7
—
—
—
0
0
173
1653
1.05
0.23
8.0
6.8
—
—
—
0
0
37
333
1.11
0.22
1.8
2.1
—
—
—
0
0
58
535
1.09
0.22
2.7
2.8
—
—
—
0
0
538
5257
1.03
0.22
2.3
2.2
0.91
1.17
e6/l
1.11
308
2768
0
11
0.00
0.21
0.0
1.1
—
124.74
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
234.38
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
49
532
0.92
0.20
1.0
1.0
—
—
—
0
0
409
4194
0.97
0.20
1.3
1.3
—
—
—
0
0
9
113
0.80
0.20
1.0
1.4
—
—
—
0
0
9
114
0.79
0.20
1.3
2.2
—
—
—
0
0
245
2371
1.03
0.19
3.4
2.4
1.72
1.64
%
0.85
214
2109
22
248
0.89
0.18
1.9
2.7
—
—
—
0
0
51
548
0.93
0.17
1.0
1.0
4.43
2.10
u/ml
0.23
15
123
134
1285
1.04
0.17
1.0
1.1
6.51
5.25
u/ml
0.15
38
509
32
291
1.10
0.17
1.4
1.7
44.00
46.91
%
0.16
23
170
25
224
1.12
0.17
1.4
1.7
2.17
2.81
u/field
0.27
12
128
5
66
0.76
0.17
1.0
1.1
0.04
0.70
u/ml
—
5
60
26
288
0.90
0.16
1.1
1.2
—
—
—
0
0
26
235
1.11
0.15
2.1
2.5
248.40
162.98
au/ml
—
5
34
111
1064
1.04
0.15
1.1
1.1
2.26
2.59
u/ml
0.20
62
605
10
119
0.84
0.15
1.5
2.6
—
16.34
—
0
14
81
851
0.95
0.15
3.2
3.5
57.42
57.12
%
0.08
81
851
28
255
1.10
0.15
1.9
2.8
—
—
—
0
0
9
82
1.10
0.15
1.2
1.1
—
—
—
0
0
19
169
1.12
0.14
2.1
1.7
3.18
2.61
mg/l
0.22
19
160
48
512
0.94
0.14
1.0
1.0
0.28
0.38
u/ml
—
6
73
966
9551
1.01
0.14
4.4
5.9
—
—
—
0
0
22
198
1.11
0.14
2.4
2.4
28.95
27.94
%
0.20
22
193
228
2339
0.97
0.14
1.4
1.4
—
—
—
0
0
30
276
1.09
0.13
2.7
2.7
3.92
22.71
nmol/l
0.45
30
264
13
113
1.15
0.13
1.1
1.1
—
—
—
0
0
17
152
1.12
0.12
1.1
1.2
—
—
—
0
0
23
210
1.10
0.12
2.5
2.4
9.43
8.17
%
0.42
23
204
15
133
1.13
0.12
1.0
1.0
—
—
—
0
0
15
133
1.13
0.12
1.0
1.0
—
—
—
0
0
15
133
1.13
0.12
1.0
1.0
—
—
—
0
0
842
8509
0.99
0.12
3.3
3.0
100.43
98.92
%
1.22
806
8215
70
670
1.05
0.11
1.5
1.6
0.50
0.61
g/l
0.64
59
517
37
347
1.07
0.11
1.2
1.1
—
—
—
0
0
17
153
1.11
0.11
2.2
2.3
—
—
—
0
0
20
182
1.10
0.11
1.3
1.2
—
—
—
0
0
15
167
0.90
0.10
1.0
1.1
—
—
—
0
0
18
198
0.91
0.10
1.5
1.4
2.36
2.78
u/field
0.08
11
142
61
583
1.05
0.10
2.0
3.1
548.86
310.70
u/ml
0.16
50
491
21
228
0.92
0.10
1.7
1.7
—
—
—
0
0
15
166
0.90
0.09
1.7
2.5
11.79
10.97
%
0.34
15
166
174
1702
1.02
0.09
1.1
1.1
2.42
1.44
u/ml
0.51
60
661
102
990
1.03
0.09
1.2
1.1
6.05
11.15
au/ml
—
10
81
99
1020
0.97
0.09
1.3
1.3
—
—
—
0
0
17
186
0.91
0.09
1.0
1.1
—
—
—
0
0
123
1198
1.03
0.09
1.0
1.1
4.82
5.42
u/ml
0.18
48
509
17
155
1.10
0.09
1.0
1.1
4.31
0.95
u/ml
0.48
12
106
6
57
1.05
0.08
1.0
1.6
—
114.84
—
0
7
12
107
1.12
0.08
1.2
1.6
8.20
7.70
ug/l
0.28
12
107
6
58
1.03
0.08
1.8
1.6
—
—
—
0
0
56
538
1.04
0.08
1.2
1.6
9.98
10.60
g/l
0.55
45
475
31
328
0.94
0.08
1.5
1.5
1.71
1.19
promille
1.26
26
253
13
117
1.11
0.08
1.0
1.0
—
—
—
0
0
45
470
0.96
0.08
1.2
1.5
39.48
39.49
g/l
0.01
40
425
14
127
1.10
0.07
1.1
1.5
3.60
5.52
%
—
5
29
32
303
1.06
0.07
2.9
2.8
—
28.71
—
0
7
7
82
0.85
0.07
1.6
1.8
—
—
—
0
0
145
1425
1.02
0.06
1.1
1.1
0.58
1.07
u/ml
1.23
45
599
144
1465
0.98
0.06
1.1
1.1
2.35
1.92
u/ml
0.18
28
375
15
161
0.93
0.05
1.8
1.8
—
—
—
0
0
25
238
1.05
0.05
1.1
1.1
5.94
2.91
u/ml
0.24
11
141
19
179
1.06
0.05
2.3
1.8
—
—
—
0
0
15
140
1.07
0.04
1.0
1.1
—
—
—
0
0
12
111
1.08
0.04
1.1
1.1
—
—
—
0
0
10
93
1.08
0.02
1.0
1.1
—
—
—
0
0
35
358
0.98
0.01
1.3
1.4
—
—
—
0
0
20
207
0.97
0.01
1.7
2.1
8.89
9.93
mg/l
0.31
14
172
19
184
1.03
0.00
1.1
1.6
—
—
—
0
0
44
446
0.99
0.00
1.3
1.6
—
—
—
0
0
20
202
0.99
0.00
1.2
1.1
—
—
—
0
0
21
212
0.99
0.00
1.0
1.0
—
—
—
0
0
47
468
1.00
0.00
5.5
5.6
328.31
366.70
umol/l
1.37
42
392
54
538
1.00
0.00
1.0
1.1
0.32
1.85
u/ml
1.17
18
143
28
275
1.02
0.00
1.2
1.3
—
260.00
—
0
7
103
1032
1.00
0.00
1.0
1.1
0.15
0.20
u/ml
0.25
13
205
19
194
0.98
0.00
2.3
2.9
291.75
178.86
umol/l
—
8
103
38
384
0.99
0.00
2.2
1.9
9.51
20.18
u/ml
0.34
31
283
22
223
0.99
0.00
1.2
1.6
—
—
—
0
0
42
423
0.99
0.00
1.0
1.1
—
—
—
0
0
48
483
0.99
0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
7.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
481.35
—
0
6
0
5
0.00
0.00
0.0
1.0
—
4.20
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
5.5
7.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_PCOS_BROAD and mortality.

Females

Parameter HR [95% CI] p-value
E4_PCOS_BROAD 1.153 [0.97, 1.38] 0.114
Birth year 0.993 [0.98, 1.0] 0.087

During the follow-up period (1.1.1998 — 31.12.2019), 197 out of 23042 females with E4_PCOS_BROAD died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_PCOS_BROAD.

N-year risk Females Males
1 0.079% No data
5 0.583% No data
10 1.507% No data
15 2.982% No data
20 5.185% No data

Relationships between endpoints

↥

Index endpoint: E4_PCOS_BROAD – Polycystic ovarian syndrome, broad definition

GWS hits: 13

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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