Carcinoma in situ of endometrium

CD2_INSITU_ENDOMETRIUM

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D07.0&
  • Hospital discharge: ICD-9 2332
  • Cause of death: ICD-10 D07.0&
  • Cause of death: ICD-9 2332

2 out of 7 registries used, show all original rules.

183

4. Check minimum number of events

None

183

5. Include endpoints

None

183

6. Filter based on genotype QC (FinnGen only)

170

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D07
Name in latin
Carcinoma in situ endometrii (corporis uteri)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 170 170 -
Unadjusted period prevalence (%) 0.06 0.06 -
Median age at first event (years) 62.65 62.65 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
174
Matched controls
1740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D07.0
ICD-10 Finland
Carcinoma in situ: Endometrium
+∞
248.5
173
*
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
78.8
166.8
98
28
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
77.5
160.9
94
26
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
37.5
135.8
111
78
8380/3-C54.1
ICD-O-3
Endometrioid adenocarcinoma, NOS, of endometrium
70.8
128.8
74
18
PJA01
NOMESCO Finland
Laparoscopic sentinel node excision
386.3
74.7
70
*
N95.0
ICD-10 Finland
Postmenopausal bleeding
10.3
53.9
89
160
B01AB10
ATC
tinzaparin; parenteral
9.6
48.1
79
139
N84.0
ICD-10 Finland
Polyp of corpus uteri
8.2
37.6
65
118
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
9.7
37.4
52
73
N85.1
ICD-10 Finland
Endometrial adenomatous hyperplasia
36.9
30.0
38
13
WF003
NOMESCO Finland
Adjuvant radiotherapy
8.6
18.8
26
35
ZXC96
NOMESCO Finland
Robot assisted procedure
21.0
18.5
27
15
ULC02
NOMESCO Finland
Hysteroscopy
5.9
17.3
35
71
N85.0
ICD-10 Finland
Endometrial glandular hyperplasia
12.6
15.7
28
26
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
21.5
14.6
21
11
SPAT1312
SPAT
General health counselling
3.4
14.4
88
401
8380/2-C54.1
ICD-O-3
Endometrioid intraepithelial neoplasia of endometrium
58.3
14.1
16
*
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
4.4
12.9
37
100
SPAT1249
SPAT
Treatment-related counselling outside office
3.0
11.7
97
512
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
4.9
11.2
27
63
8380/3-C54.9
ICD-O-3
Endometrioid adenocarcinoma, NOS, of corpus uteri
23.3
10.9
15
7
LCA06
NOMESCO Finland
Biopsy of endometrium
3.3
10.7
52
201
JN4BD
NOMESCO Finland
Extensive body CT
3.7
10.4
39
127
TLC00
NOMESCO Finland
Insertion of intrauterine device
5.5
9.8
20
40
B01AB05
ATC
enoxaparin; parenteral
2.7
9.6
87
467
ZX040
NOMESCO Finland
Intracavity HDR radiotherapy
38.9
9.1
11
*
SPAT1310
SPAT
Counselling related to known health issue
2.6
8.9
80
424
C54.10
ICD-10 Finland
Malignant tumor of endometrium without histology
52.7
8.8
10
*
UJF32
NOMESCO Finland
Coloscopy
2.7
8.7
69
343
SPAT1301
SPAT
No procedures
2.6
8.7
79
421
SPAT1260
SPAT
Consultation of another employee
2.9
8.6
50
211
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.6
8.4
78
417
WF090
NOMESCO Finland
Profylactic radiotherapy
+∞
8.4
8
*
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
15.5
8.3
13
9
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
3.5
7.8
29
93
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.0
7.6
23
64
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
8.3
7.6
16
21
LCB14
NOMESCO Finland
Laparoscopic myolysis
14.2
7.5
12
9
128
Kela drug reimbursment
Cancers of female genital organs
6.3
7.5
19
33
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
7.9
7.4
16
22
YX9VG
NOMESCO Finland
Other MRI eamination with high intensity magnet for dose design of radiotherapy
+∞
7.3
7
*
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
4.2
7.2
20
52
WX408
NOMESCO Finland
General anesthesy, balanced
0.2
7.2
7
321
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.4
6.9
69
375
SPAT1153
SPAT
Removal of sutures
2.3
6.8
75
426
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.0
6.7
20
55
JN4AD
NOMESCO Finland
Body CT examination
2.9
6.5
34
134
ZXE00
NOMESCO Finland
One hour or less
0.3
6.5
21
536
E66.01
ICD-10 Finland
Obesity due to excess calories
3.0
6.1
29
108

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
74
9.60
37.01
4.2
4.9
36.75
36.95
°c
2.15
52
74
124
493
6.27
29.72
6.2
4.5
0.00
0.00
estimate
-0.00
23
180
65
148
6.41
29.44
1.4
2.3
0.24
0.21
g/l
2.50
65
141
108
394
5.59
28.30
7.1
4.5
1.02
1.02
kg/l
2.01
66
270
111
419
5.55
27.77
6.1
4.4
—
0.17
—
0
6
49
101
6.36
24.22
6.2
7.7
24.59
25.61
mmol/l
1.52
49
95
44
101
5.49
19.08
4.0
7.6
95.07
94.81
%
0.24
44
101
129
666
4.62
18.93
6.0
4.3
0.00
0.03
estimate
1.02
19
150
124
711
3.59
13.63
6.0
4.0
6.87
6.28
ph
7.32
71
386
132
793
3.75
13.34
2.6
2.6
—
—
estimate
—
0
0
53
189
3.59
12.53
3.8
6.6
7.40
7.42
ph
1.59
48
120
53
191
3.55
12.31
3.8
6.4
5.23
5.25
kpa
0.06
53
185
53
191
3.55
12.31
3.8
6.4
13.75
12.49
kpa
0.86
53
185
53
192
3.53
12.20
3.7
6.4
1.24
1.45
mmol/l
0.27
40
168
49
171
3.60
11.92
3.8
6.6
97.74
96.20
%
3.11
49
164
138
896
3.61
11.41
6.4
4.4
0.00
0.00
estimate
-0.00
23
187
139
907
3.65
11.38
6.5
4.5
0.00
0.02
estimate
0.68
24
183
138
905
3.54
11.03
6.5
4.5
0.00
0.00
estimate
-0.00
23
194
125
775
3.18
10.98
3.9
3.9
36.83
35.85
g/l
1.63
116
726
43
167
3.09
8.59
2.0
1.5
—
—
—
0
0
17
535
0.24
8.01
9.4
5.7
—
—
—
0
0
17
45
4.08
5.97
23.9
7.8
—
—
—
0
0
104
1294
0.51
4.29
14.2
20.4
14.33
13.70
%
3.03
104
1279
5
188
0.24
3.52
1.0
2.3
5.40
6.40
umol/l
—
5
165
61
394
1.84
3.45
5.1
4.9
—
—
—
0
0
80
569
1.75
3.24
3.1
3.1
21.50
28.30
mg/l
0.24
53
324
76
534
1.75
3.20
2.8
2.3
48.96
66.43
u/l
1.32
71
481
93
696
1.72
3.10
2.4
2.1
—
—
—
0
0
84
620
1.69
2.89
5.4
3.8
65.82
29.08
ng/l
0.40
69
447
118
954
1.74
2.88
8.1
9.6
4.35
3.94
e9/l
0.97
112
838
64
440
1.72
2.85
1.2
1.3
—
—
—
0
0
80
585
1.68
2.83
3.4
3.8
5.14
5.40
mg/mmol
0.02
52
320
5
6
8.53
2.76
2.0
2.2
—
—
—
0
0
20
95
2.25
2.61
2.2
2.3
0.73
0.63
%
0.59
20
95
79
587
1.63
2.56
3.0
3.0
7.32
6.36
mmol/l
1.40
74
472
20
96
2.22
2.55
2.2
2.4
1.29
1.14
%
0.43
20
96
102
810
1.63
2.51
4.5
5.4
1.17
1.22
mmol/l
7.47
95
737
160
1444
2.34
2.50
5.0
4.4
1.38
1.25
mmol/l
1.86
147
1311
168
1570
3.03
2.44
16.6
14.3
—
—
—
0
0
24
414
0.51
2.43
2.6
3.5
85.46
94.55
%
0.77
24
406
165
1527
2.56
2.40
18.7
16.1
26.60
21.06
mg/l
0.90
143
1250
150
1328
1.94
2.39
6.5
4.9
15.52
14.91
pmol/l
2.28
143
1217
83
647
1.54
2.08
3.6
3.3
—
—
—
0
0
166
1558
2.42
1.95
7.1
6.3
2.72
2.76
mmol/l
0.28
156
1436
39
558
0.61
1.95
3.3
3.4
—
—
—
0
0
70
532
1.53
1.94
5.6
6.6
—
—
—
0
0
5
136
0.35
1.85
1.6
1.2
—
—
—
0
0
27
168
1.72
1.68
1.3
1.6
—
—
—
0
0
33
476
0.62
1.67
4.0
3.8
0.00
0.00
estimate
-0.00
19
152
5
128
0.37
1.57
2.8
2.7
46.40
220.24
ng/l
—
5
117
160
1489
1.93
1.56
7.7
6.6
40.73
39.20
mmol/mol
1.41
154
1391
52
387
1.49
1.55
2.2
2.6
326.48
322.86
umol/l
0.08
44
338
0
43
0.00
1.54
0.0
2.4
—
61.70
—
0
43
66
815
0.69
1.52
2.2
2.1
96.27
100.96
pmol/l
0.51
46
368
5
123
0.39
1.43
1.2
2.4
—
—
—
0
0
11
206
0.50
1.41
1.4
1.6
—
—
—
0
0
35
244
1.54
1.40
1.8
2.1
—
—
—
0
0
163
1535
1.98
1.39
6.0
5.4
4.71
4.81
mmol/l
0.75
153
1416
139
1260
1.51
1.37
6.5
8.1
79.65
77.74
u/l
0.21
133
1176
55
423
1.44
1.37
3.3
3.7
—
—
—
0
0
68
549
1.39
1.28
1.9
2.1
—
—
—
0
0
31
426
0.67
1.21
1.3
1.2
0.70
1.63
u/ml
0.90
14
114
161
1521
1.78
1.19
5.6
5.3
1.52
1.62
mmol/l
2.48
151
1393
19
119
1.67
1.17
1.3
1.3
—
—
—
0
0
0
35
0.00
1.16
0.0
1.1
—
—
—
0
0
12
203
0.56
1.12
1.4
1.5
—
—
—
0
0
62
744
0.74
1.08
1.8
1.9
1.42
1.30
mmol/l
0.58
55
616
13
212
0.58
1.07
1.3
1.2
—
—
—
0
0
11
60
1.89
1.05
1.4
1.2
—
—
—
0
0
161
1530
1.70
1.03
6.5
5.4
6.19
5.90
mmol/l
2.47
153
1411
159
1508
1.63
1.00
7.6
6.2
2.49
1.92
mu/l
0.66
152
1392
77
655
1.31
0.99
3.4
3.3
2.39
2.37
mmol/l
1.04
70
586
5
23
2.21
0.98
2.4
2.1
—
—
—
0
0
0
29
0.00
0.98
0.0
2.4
—
5.20
—
0
29
9
152
0.57
0.94
1.2
1.3
—
—
—
0
0
5
105
0.46
0.92
2.2
6.2
25.48
24.90
mmol/l
—
5
105
48
386
1.34
0.90
1.6
1.7
0.67
1.25
mg/l
2.00
38
306
6
30
2.03
0.88
1.0
1.1
—
—
—
0
0
0
24
0.00
0.80
0.0
1.4
—
0.81
—
0
17
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
0
24
0.00
0.80
0.0
1.4
—
1.23
—
0
15
0
25
0.00
0.79
0.0
1.6
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
100
899
1.26
0.78
4.8
6.2
1.17
1.22
mmol/l
5.62
90
768
42
340
1.31
0.75
1.6
1.7
469.21
468.15
pmol/l
0.01
33
278
6
109
0.53
0.75
1.2
1.7
1.09
1.52
g/l
—
6
100
9
137
0.64
0.63
3.3
2.7
9.20
10.01
g/l
—
9
127
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
5
89
0.55
0.57
2.2
7.7
17.52
15.78
%
—
5
84
29
233
1.29
0.55
1.4
1.7
26.96
28.97
s
1.61
29
225
11
75
1.50
0.52
1.6
3.1
25.07
25.65
mmol/l
0.27
11
75
21
164
1.32
0.49
2.0
3.2
7.40
7.39
ph
—
10
95
5
81
0.61
0.47
2.0
2.9
7.41
7.43
ph
—
5
63
9
127
0.69
0.45
2.3
4.2
—
—
—
0
0
85
783
1.17
0.43
37.8
11.4
1.38
1.19
inr
1.95
74
634
15
114
1.35
0.42
1.3
1.4
—
—
—
0
0
11
79
1.42
0.42
1.7
4.3
1.35
1.53
%
1.10
11
74
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
10
71
1.43
0.40
1.5
4.7
0.61
0.90
%
—
10
66
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
308.77
—
0
13
5
36
1.40
0.38
4.0
1.7
9.28
5.76
pmol/l
—
5
36
32
368
0.84
0.35
1.3
1.4
29.86
35.44
iu/ml
0.13
12
124
48
434
1.15
0.30
2.5
2.2
4.63
3.10
mg/l
2.05
42
370
11
140
0.77
0.29
1.3
1.7
—
—
—
0
0
14
169
0.81
0.25
1.5
1.4
—
—
—
0
0
62
577
1.12
0.25
3.2
3.5
7.40
7.40
ph
0.20
48
402
18
210
0.84
0.23
1.4
1.3
—
—
—
0
0
7
92
0.75
0.23
1.7
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
18
155
1.18
0.21
3.5
4.7
1.67
0.94
%
—
6
48
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
1.42
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
9.93
—
0
14
81
774
1.09
0.18
2.9
3.0
115.97
90.77
ug/l
0.81
76
715
18
205
0.86
0.18
1.4
1.9
71.67
121.37
ug/g
0.87
18
156
5
65
0.76
0.17
1.6
1.6
—
14.31
—
0
9
27
247
1.11
0.14
1.0
1.2
—
—
—
0
0
8
96
0.83
0.14
1.3
1.3
—
—
—
0
0
71
737
0.94
0.12
10.7
11.1
0.00
0.00
e9/l
0.36
66
606
5
48
1.04
0.09
2.0
2.8
1.46
1.46
mmol/l
—
5
48
5
64
0.77
0.08
1.0
1.1
—
—
—
0
0
11
99
1.12
0.06
1.6
1.2
—
—
—
0
0
35
339
1.04
0.04
1.3
1.4
11.23
13.10
u/ml
0.07
24
134
86
849
1.03
0.03
6.3
5.8
0.04
0.04
e9/l
0.53
81
723
20
207
0.96
0.01
1.4
1.4
—
—
—
0
0
10
99
1.01
0.00
1.6
2.0
—
—
—
0
0
18
176
1.03
0.00
2.4
2.0
418.39
378.93
nmol/l
0.44
18
168
63
635
0.99
0.00
3.0
4.1
16.98
112.04
e6/l
2.93
54
437
84
843
0.99
0.00
6.4
5.8
0.51
0.56
e9/l
0.88
78
720
12
122
0.98
0.00
1.8
6.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
0.00
—
0
5
0
7
0.00
-0.00
0.0
6.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
9
97
0.92
-0.00
2.1
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
42.02
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
0.60
—
0
6
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
35.6
—
89.29
—
0
7
0
7
0.00
-0.00
0.0
3.4
—
51.86
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
1.11
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
136.00
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
0.02
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
66
0.91
-0.00
1.8
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1.33
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
14.4
—
848.71
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
87.56
—
0
7
0
9
0.00
-0.00
0.0
1.8
—
66.22
—
0
9
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
55
0.91
-0.00
2.0
6.2
1.28
1.17
mmol/l
—
5
48
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_ENDOMETRIUM – Carcinoma in situ of endometrium

GWS hits: 1

This endpoint is excluded from FinRegistry analyses (omitted endpoint).