Mixed connective tissue disease

M13_MCTD

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M35.1
  • Cause of death: ICD-10 M35.1

2 out of 7 registries used, show all original rules.

746

4. Check minimum number of events

None

746

5. Include endpoints

None

746

6. Filter based on genotype QC (FinnGen only)

673

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M35
Name in latin
Alia syndromata mixta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 673 518 155
Unadjusted period prevalence (%) 0.16 0.18 0.07
Median age at first event (years) 53.66 52.01 59.19

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
689
Matched controls
6890
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L04AX03
ATC
methotrexate; systemic
17.3
309.0
333
353
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
39.1
307.7
481
385
P01BA02
ATC
hydroxychloroquine; oral
54.2
307.7
480
280
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
307.7
689
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
16.7
256.1
256
235
L04AX01
ATC
azathioprine; systemic
22.9
221.3
174
100
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
1193.8
191.2
178
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
269.9
183.1
180
9
C08CA05
ATC
nifedipine; systemic
12.4
156.5
176
186
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
10.9
151.6
190
233
XX9XE
NOMESCO Finland
Other ultrasound examination
47.0
139.8
83
20
L01BA01
ATC
methotrexate; systemic
15.5
133.3
124
96
H02AB06
ATC
prednisolone; systemic
8.9
131.1
570
2409
L04AA06
ATC
mycophenolic acid; systemic
32.8
128.1
84
29
L88
ICPC
Rheumatoid/seropositive arthritis
13.2
125.1
129
118
M35.3
ICD-10 Finland
Polymyalgia rheumatica
23.4
123.5
92
45
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.3
119.4
474
1796
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
1138.6
103.0
98
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.4
94.3
158
266
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
506.4
91.5
89
*
H02AB07
ATC
prednisone; oral
5.5
87.0
214
519
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
6.1
86.2
182
384
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
7.5
76.9
123
195
I73.0
ICD-10 Finland
Raynaud syndrome
14.6
69.0
64
48
M05BA04
ATC
alendronic acid; oral
5.6
68.6
153
335
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
7.6
63.6
98
148
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.7
59.0
458
2399
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
7.1
48.7
78
122
PAW37
NOMESCO Finland
Biopsy of temporal artery
251.8
46.6
47
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
45.8
304
1391
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
42.1
40
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
9.8
40.5
48
52
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.0
40.0
131
381
R4120
NOMESCO Finland
Occupational therapy
4.7
38.2
97
232
R50.9
ICD-10 Finland
Fever, unspecified
3.4
38.0
168
596
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
8.9
36.9
47
56
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
6.9
35.5
57
89
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
34.7
33
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
7.2
34.0
52
77
L04AA01
ATC
[U] ciclosporin
13.4
33.4
32
25
ZX120
NOMESCO Finland
Intravenous
3.8
33.3
116
350
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
342.7
33.2
33
*
L04AA13
ATC
[U] leflunomide
7.3
33.1
50
73
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.6
32.3
83
200
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.5
31.5
84
208
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
31.5
30
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
7.9
31.3
44
59
M05BA07
ATC
risedronic acid; oral
6.0
29.7
55
99
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.9
29.2
175
730
M13.9
ICD-10 Finland
Arthritis, unspecified
3.9
28.7
93
266
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
292.8
28.0
28
*
XPX04
NOMESCO Finland
Angioscopy
151.1
27.8
29
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
27.4
205
955
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.6
27.2
214
1020
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.7
27.2
53
100
L04AD01
ATC
ciclosporin; systemic
9.3
27.0
33
37
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.5
27.0
105
339
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
6.3
26.2
45
75
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
+∞
26.2
25
*
C08CA02
ATC
felodipine; oral
3.5
26.1
101
325
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
25.3
131
501
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
25.2
24
*
XG410
NOMESCO Finland
Flow-volume spirometry
5.3
25.1
52
104
A07EC01
ATC
sulfasalazine; oral, rectal
3.6
24.7
91
283
H02AB04
ATC
methylprednisolone; systemic
2.8
24.1
143
588
H04.10
ICD-10 Finland
Dry eye syndrome
2.8
23.5
135
545
A07AA02
ATC
nystatin; oral
3.8
23.4
76
217
A02BC02
ATC
pantoprazole; systemic
2.5
23.2
528
3906
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
23.2
369
2353
SBA10
NOMESCO Finland
Measurement of salivary flow rate
18.8
22.4
34
19
GD1AD
NOMESCO Finland
Thorax CT examination
3.8
22.0
73
211
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.2
21.7
60
152
TGC00
NOMESCO Finland
Bronchial lavation
5.8
21.6
40
72
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
27.4
21.5
29
11
NH3EA
NOMESCO Finland
Feet X-ray examination with load
6.4
21.3
36
59
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
8.7
21.1
27
32
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
20.7
201
1038
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
7.0
20.1
31
46
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.0
20.0
98
361
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
19.9
102
386
M05BX04
ATC
denosumab; parenteral
3.5
19.7
73
227
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
205.7
19.7
20
*
H02AB09
ATC
hydrocortisone; systemic
6.1
19.3
34
58
WZA10
NOMESCO Finland
Extensive medical or dental certificate
8.1
19.3
26
33
E0000UV, ,
ATC
2.1
18.9
338
2198
7108X
ICD-9 Finland
Diffuse diseases of connective tissue, Other specified diffuse diseases of connective tissue
+∞
18.8
18
*
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
6.0
18.5
33
57
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.8
18.4
34
61
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
6.2
17.9
31
52
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
5.4
17.9
36
70
M35.5
ICD-10 Finland
Multifocal fibrosclerosis
+∞
17.8
17
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.1
17.6
77
265
R06.0
ICD-10 Finland
Dyspnoea
2.1
17.5
232
1342
C03CA01
ATC
furosemide; systemic
2.1
17.4
226
1298
G04BE03
ATC
sildenafil; oral
18.0
17.0
26
15
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
5.0
17.0
37
77
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
6.6
16.8
27
42
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.5
16.6
41
95
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.7
16.6
98
398
M33.2
ICD-10 Finland
Polymyositis
174.0
16.6
17
*
M35
ICD-10 Finland
Other systemic involvement of connective tissue
174.0
16.6
17
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.1
16.4
71
243
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
16.2
202
1137
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
16.1
78
285
A02BC03
ATC
lansoprazole; oral
2.0
16.0
232
1379
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.9
15.9
80
298
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
15.8
181
984
M01AH01
ATC
celecoxib; oral
2.2
15.6
154
789
I77.6
ICD-10 Finland
Arteritis, unspecified
87.1
15.6
17
*
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
22.7
15.6
22
10
D64.9
ICD-10 Finland
Anaemia, unspecified
2.7
15.5
94
387
UJF32
NOMESCO Finland
Coloscopy
2.1
15.4
202
1155
L93.0
ICD-10 Finland
Discoid lupus erythematosus
24.0
15.2
21
9
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.1
15.1
42
107
A02BC01
ATC
omeprazole; systemic
2.0
14.9
218
1294
J01FF01
ATC
clindamycin; systemic
2.0
14.8
217
1288
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.4
14.7
115
533
UJF30
NOMESCO Finland
Ileoscopy through colon
2.6
14.7
94
397
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
14.6
14
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
14.6
14
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.6
14.6
95
404
Z3231
NOMESCO Finland
Registered nurse
2.0
14.6
210
1239
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.4
14.3
54
170
A02BC05
ATC
esomeprazole; systemic
1.9
14.3
312
2111
J01DB01
ATC
cefalexin; oral
2.4
14.1
593
4981
C08CA01
ATC
amlodipine; oral
1.9
14.0
282
1856
K11.2
ICD-10 Finland
Sialoadenitis
4.0
14.0
40
104
J01MA12
ATC
levofloxacin; systemic
2.2
13.8
145
759
D07AC01
ATC
betamethasone; topical
1.9
13.8
274
1793
N02AX02
ATC
tramadol; systemic, rectal
1.9
13.8
316
2163
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.6
13.7
46
134
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
5.2
13.5
28
56
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.7
13.4
78
314
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
4.9
13.2
29
61
L99
ICPC
Musculoskeletal disease other
5.2
13.0
27
54
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
12.9
279
1864
M13.0
ICD-10 Finland
Polyarthritis, unspecified
10.8
12.8
24
23
A01AB09
ATC
miconazole; local oral
2.6
12.8
80
333
M33.9
ICD-10 Finland
Dermatopolymyositis, unspecified
+∞
12.5
12
*
G73.7*M35.0
ICD-10 Finland
Myopathy in sicca syndrome [Sjögren]
+∞
12.5
12
*
M32
ICD-10 Finland
Systemic lupus erythematosus
+∞
12.5
12
*
M35.7
ICD-10 Finland
Hypermobility syndrome
20.5
12.5
18
9
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
132.3
12.5
13
*
M79.7
ICD-10 Finland
Fibromyalgia
3.9
12.4
37
99
N03AX16
ATC
[U] pregabalin
2.0
12.4
176
1026
J01MA14
ATC
moxifloxacin; systemic
2.6
12.3
78
327
A02BA02
ATC
ranitidine; systemic
2.0
12.3
152
843
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.7
12.2
69
273
TNG10
NOMESCO Finland
Puncture of knee
6.2
12.2
21
35
L20
ICPC
Joint symptom/complaint NOS
3.4
12.0
43
131
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
11.9
116
587
J01MA02
ATC
ciprofloxacin; systemic
1.8
11.9
270
1821
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
5.5
11.9
23
43
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
11.8
100
478
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
11.5
11
*
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
11.5
11
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
11.5
11
*
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
11.5
11
*
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
11.5
11
*
B02.9
ICD-10 Finland
Zoster without complication
2.7
11.3
65
260
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.4
11.3
40
121
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
11.2
225
1457
M05BB03
ATC
alendronic acid and colecalciferol; oral
4.3
11.2
29
70
TEA00
NOMESCO Finland
Biopsy of lip
11.4
11.1
20
18
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
11.1
69
287
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.8
11.0
33
89
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
10.9
302
2141
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
10.8
67
278
M31.6
ICD-10 Finland
Other giant cell arteritis
61.0
10.7
12
*
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
4.4
10.6
27
64
S97
ICPC
Chronic ulcer skin
2.8
10.5
55
209
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.4
10.5
79
358
J05AB01
ATC
aciclovir; systemic
1.8
10.5
178
1093
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
10.5
142
810
C02KX04
ATC
macitentan; oral
+∞
10.4
10
*
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
10.4
10
*
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.0
10.4
29
74
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
10.8
10.3
19
18
A01AB04
ATC
amphotericin B; local oral
3.0
10.3
47
166
M01AH02
ATC
rofecoxib; oral
2.1
10.2
102
520
P01BA01
ATC
chloroquine; systemic
13.4
10.2
17
13
S18
ICPC
Laceration/cut
1.7
10.0
337
2502
J02AC01
ATC
fluconazole; systemic
1.7
10.0
313
2280
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
7.8
10.0
22
29
D68.8
ICD-10 Finland
Other specified coagulation defects
7.8
10.0
22
29
N03AX12
ATC
[U] gabapentin; oral
2.0
9.9
124
686
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.4
9.9
25
59
M05BA06
ATC
ibandronic acid; systemic
4.4
9.9
25
59
L01AA01
ATC
cyclophosphamide; systemic
26.4
9.8
13
5
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.2
9.7
85
411
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.5
9.7
33
97
M01AC06
ATC
meloxicam; systemic, rectal
1.7
9.6
272
1923
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
4.5
9.6
23
52
S01XA18
ATC
ciclosporin; ophthalmic
9.3
9.6
19
21
M60.9
ICD-10 Finland
Myositis, unspecified
15.3
9.5
15
10
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.9
9.5
44
157
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.3
9.4
24
57
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
101.4
9.4
10
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.5
9.4
32
94
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
5.3
9.4
19
37
M33.1
ICD-10 Finland
Other dermatomyositis
+∞
9.4
9
*
NXL00
NOMESCO Finland
Biopsy of muscle
22.0
9.4
13
6
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.4
9.4
67
297
NF1AA
NOMESCO Finland
Hip X-ray examination
2.3
9.3
72
330
N06AA09
ATC
amitriptyline; systemic
2.3
9.3
76
357
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
9.3
208
1379
M25.5
ICD-10 Finland
Pain in joint
1.7
9.2
254
1782
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
8.5
9.1
19
23
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
9.0
60
257
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
9.0
141
839
K11.70
ICD-10 Finland
Hypoptyalism
12.7
8.9
15
12
H25.8
ICD-10 Finland
Other senile cataract
2.2
8.9
82
405
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.2
8.8
35
114
K75.4
ICD-10 Finland
Autoimmune hepatitis
50.6
8.7
10
*
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.5
8.7
21
48
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
8.6
96
509
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
8.4
8.6
18
22
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
8.4
8.6
18
22
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.9
8.6
40
143
J01AA02
ATC
doxycycline; systemic
1.8
8.5
534
4568
R4110
NOMESCO Finland
Physiotherapy
1.7
8.5
197
1312
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
8.5
127
745
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
8.0
8.4
18
23
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
13.0
8.4
14
11
C02KX01
ATC
bosentan; oral
+∞
8.3
8
*
ZX140
NOMESCO Finland
Intra articular
10.9
8.3
15
14
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
9.6
8.3
16
17
M01CB01
ATC
sodium aurothiomalate; parenteral
6.6
8.2
20
31
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.2
265
1919
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
8.1
66
310
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
8.0
83
428
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.4
8.0
28
84
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
8.0
90
479
N06AX21
ATC
duloxetine; oral
2.0
8.0
96
523
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.5
8.0
52
221
J05AB11
ATC
valaciclovir; oral
1.8
8.0
121
712
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.1
7.8
73
362
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
15.2
7.7
12
8
ELA30
NOMESCO Finland
Biopsy of salivary gland
45.5
7.7
9
*
A46
ICD-10 Finland
Erysipelas
1.9
7.7
98
544
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
4.1
7.7
21
53
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
12.0
7.6
13
11
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
6.3
7.6
19
31
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.8
7.6
37
136
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
7.6
363
2868
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
2.9
7.5
35
125
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.9
7.5
34
120
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.3
7.5
28
88
E000002, ,
ATC
2.0
7.5
79
411
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.9
7.4
35
126
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
13.5
7.4
12
9
NJ3BG
NOMESCO Finland
MRI examination of extremities with high intensity magnet
13.5
7.4
12
9
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.0
7.4
83
441
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.9
7.4
99
559
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.0
7.4
32
110
Z3226
NOMESCO Finland
Physiotherapist
1.8
7.3
129
793
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
3.0
7.3
31
105
M35.2
ICD-10 Finland
Behçet disease
+∞
7.3
7
*
D07AD01
ATC
clobetasol; topical
1.8
7.3
126
771
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.0
7.3
32
111
SPF10
NOMESCO Finland
Demanding reparation of dental prosthesis
4.6
7.2
17
38
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
20.3
7.1
10
5
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
2.6
7.1
41
164
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
12.2
7.1
12
10
M02AA10
ATC
ketoprofen; topical
1.8
7.1
113
675
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.2
7.0
57
268
H05AA02
ATC
teriparatide; parenteral
13.9
6.9
11
8
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.1
6.8
28
93
J01FA01
ATC
erythromycin; systemic
1.9
6.8
97
558
WX892
NOMESCO Finland
Monitored bed care
2.3
6.8
53
244
1XC02, ,
NOMESCO Finland
9.4
6.8
13
14
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
6.2
6.8
17
28
M01AB55
ATC
diclofenac, combinations; oral
2.3
6.8
52
238
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.4
6.8
47
206
NH3AE
NOMESCO Finland
Feet ultrasound examination
16.9
6.8
10
6
B01AA03
ATC
warfarin; systemic
1.8
6.8
110
660
J01FA10
ATC
azithromycin; systemic
1.5
6.7
401
3291
D70.89
ICD-10 Finland
Neutropenic splenomegaly
6.0
6.6
17
29
M79.6
ICD-10 Finland
Pain in limb
1.5
6.6
314
2450
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
3.0
6.6
28
95
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.9
6.6
30
106
Z2221
NOMESCO Finland
Medical doctor
1.6
6.6
192
1344
318
Kela drug reimbursment
Teriparatide
12.4
6.6
11
9
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.7
6.6
151
996
L28
ICPC
Limited function/disability (L)
1.7
6.6
132
841
XW000
NOMESCO Finland
Bone marrow biopsy
2.9
6.6
31
112
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
2.9
6.6
31
112
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.9
6.6
31
112
SPAT1255
SPAT
Intravenous administration of medicine
2.4
6.5
44
190
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.9
6.5
79
431
WX204
NOMESCO Finland
Axillary plexus blockaced
2.8
6.5
32
118
E000001, ,
ATC
1.7
6.5
137
884
B01AB05
ATC
enoxaparin; parenteral
1.6
6.4
214
1543
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
14.5
6.4
10
7
R03AC02
ATC
salbutamol; inhalant
1.5
6.4
384
3139
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.4
6.4
42
180
N02AC04
ATC
dextropropoxyphene; oral
3.0
6.3
27
92
NG1DA
NOMESCO Finland
X-ray of knees
3.5
6.3
21
61
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
9.4
6.3
12
13
TPX00
NOMESCO Finland
Biopsy of artery or vein
+∞
6.3
6
*
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
6.3
6
*
M05.2
ICD-10 Finland
Rheumatoid vasculitis
+∞
6.3
6
*
7109X
ICD-9 Finland
Diffuse diseases of connective tissue, Unspecified diffuse connective tissue disease
+∞
6.3
6
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
6.3
6
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
6.2
103
620
I27.0
ICD-10 Finland
Primary pulmonary hypertension
26.9
6.2
8
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
6.2
192
1360
R1250
NOMESCO Finland
Evaluation of functional capability
3.3
6.2
23
72
ZX100
NOMESCO Finland
Oral
5.8
6.2
16
28
TQW40
NOMESCO Finland
Remowal of suture of skin
2.2
6.1
50
235
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.4
6.1
42
183
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.8
6.1
92
538
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.5
6.1
37
152
J47
ICD-10 Finland
Bronchiectasis
3.8
6.1
18
48
L60.0
ICD-10 Finland
Ingrowing nail
2.4
6.1
41
177
M01CB03
ATC
auranofin; oral
8.7
6.1
12
14
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.9
6.1
84
479
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
6.1
132
858
NDL52
NOMESCO Finland
Tenosynovectomy of hand
6.8
6.1
14
21

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
292
157
31.54
307.65
2.2
1.2
48.23
3.21
u/ml
14.63
164
16
264
119
35.34
307.65
2.0
1.1
2.97
13.90
u/ml
—
41
6
343
215
30.78
307.65
5.4
1.3
20.63
4.61
iu/ml
1.24
152
39
293
156
31.94
307.65
2.1
1.2
16.39
2.27
u/ml
2.42
98
11
294
168
29.78
307.65
2.1
1.2
37.01
1.23
u/ml
—
40
7
233
134
25.76
300.02
2.2
1.1
51.82
18.95
u/ml
—
56
10
227
213
15.40
222.11
2.2
1.1
1.98
2.42
u/ml
0.09
13
12
398
852
9.69
204.41
2.3
1.3
1511.20
382.00
titre
20.46
241
180
88
21
47.89
148.75
1.4
1.2
—
—
—
0
0
94
44
24.58
128.58
1.5
1.1
—
—
—
0
0
91
42
24.81
125.10
1.5
1.1
—
—
—
0
0
476
2036
5.33
96.98
15.7
5.5
—
—
—
0
0
66
26
27.97
95.80
1.2
1.0
—
—
—
0
0
593
3108
7.52
92.37
18.1
5.6
0.57
0.57
e9/l
0.24
563
2658
594
3119
7.56
92.29
18.1
5.6
0.04
0.04
e9/l
1.73
563
2667
566
2871
6.44
90.98
18.3
5.7
2.51
2.80
%
3.02
557
2691
566
2876
6.42
90.63
18.6
5.8
9.63
8.73
%
11.40
557
2701
563
2862
6.29
89.68
18.7
5.8
0.68
0.70
%
0.30
552
2673
436
1820
4.80
89.44
4.7
2.1
125.19
210.98
u/l
1.52
418
1728
566
2897
6.34
89.20
17.8
5.6
58.69
57.23
%
2.24
559
2764
180
368
6.27
88.32
2.3
1.8
1.31
1.37
g/l
0.15
174
341
594
3187
7.26
87.91
18.4
5.7
1.56
1.92
e9/l
12.18
565
2811
568
2942
6.30
87.44
18.4
5.7
26.20
28.01
%
4.11
560
2796
595
3225
7.19
86.16
18.7
5.9
0.15
0.19
e9/l
7.71
566
2815
606
3489
7.12
77.29
20.2
9.0
3.75
4.02
e9/l
2.71
576
3029
76
64
13.22
76.71
1.7
1.2
—
—
—
0
0
192
497
4.97
71.01
8.7
4.4
0.00
0.14
%
3.71
60
139
193
504
4.93
70.58
7.8
4.3
0.54
0.71
%
0.52
65
158
193
510
4.87
69.47
9.2
4.7
0.00
0.19
%
1.53
57
134
196
530
4.77
68.47
8.6
4.3
0.62
1.09
%
1.95
65
171
387
1730
3.82
66.18
4.3
3.1
865.44
1206.55
ng/l
1.46
349
1476
235
763
4.16
64.00
4.4
3.0
3.57
5.13
e9/l
2.22
204
669
42
15
29.75
62.59
1.2
1.0
—
—
—
0
0
42
15
29.75
62.59
1.2
1.0
—
—
—
0
0
42
15
29.75
62.59
1.2
1.0
—
—
—
0
0
107
182
6.78
62.16
2.9
2.0
109.29
266.50
ug/l
2.79
100
173
63
60
11.46
58.50
2.7
2.1
—
—
—
0
0
72
86
9.23
56.75
1.7
1.2
5.25
7.35
u/ml
0.25
44
34
127
285
5.24
54.77
2.7
2.1
0.00
0.01
estimate
0.49
48
84
540
3264
4.03
53.31
7.6
3.8
0.00
0.00
estimate
0.50
155
680
543
3300
4.05
53.03
7.8
3.8
8.31
7.06
estimate
0.05
165
695
545
3326
4.06
52.75
7.9
3.8
0.00
0.48
estimate
0.53
160
656
95
172
6.25
51.59
1.6
1.1
—
—
—
0
0
172
564
3.73
44.50
2.6
2.0
0.00
0.03
estimate
0.50
56
110
479
2887
3.16
43.03
3.7
2.5
80.76
77.67
nmol/l
1.80
455
2610
450
2642
3.03
41.95
5.9
3.4
6.33
6.25
ph
0.83
242
1503
275
1242
3.02
41.64
1.5
1.3
59.23
31.57
iu/ml
1.64
109
380
492
3056
3.13
40.98
8.9
7.0
1.22
1.22
mmol/l
1.15
431
2638
285
1329
2.95
40.49
1.9
1.5
2.44
2.38
g/l
0.25
226
799
292
1381
2.93
40.40
11.5
4.6
—
—
—
0
0
147
464
3.76
39.92
2.1
3.3
67.73
67.09
g/l
0.39
142
430
128
385
3.86
37.13
1.7
2.9
—
—
—
0
0
38
37
10.81
34.50
2.2
2.2
867.45
1148.22
e6/l
1.01
31
32
339
1842
2.65
34.45
7.0
3.8
0.00
0.00
estimate
0.80
153
650
623
4659
4.52
34.44
17.7
7.7
73.32
78.43
u/l
3.08
613
4412
243
1122
2.80
34.11
1.4
1.3
16.09
10.91
u/ml
0.49
102
417
162
604
3.20
33.39
2.0
1.9
342.92
391.83
nmol/l
1.71
155
568
52
82
6.78
32.04
2.0
1.3
0.81
0.51
g/l
0.83
37
70
431
2733
2.54
30.26
23.2
10.5
0.00
0.00
e9/l
0.82
395
2225
378
2258
2.49
30.21
6.7
3.7
138.22
88.18
e6/l
0.47
282
1556
427
2748
2.46
28.22
7.1
6.3
1.22
1.22
mmol/l
0.79
402
2532
200
921
2.65
27.34
3.1
2.5
2.32
2.35
g/l
0.28
187
859
36
45
8.39
27.10
1.7
1.3
2.68
2.77
g/l
0.08
28
35
254
1334
2.43
26.06
3.5
2.5
4.03
7.17
e6/l
3.39
235
1217
164
698
2.77
26.06
1.5
1.6
—
—
—
0
0
33
10
34.57
25.77
1.2
1.3
—
—
—
0
0
35
45
8.14
25.74
1.7
1.3
8.55
5.96
g/l
1.39
27
35
35
45
8.14
25.74
1.7
1.3
0.33
0.36
g/l
0.15
27
35
283
1566
2.37
25.73
5.0
4.0
—
—
—
0
0
312
1802
2.34
25.67
7.0
3.2
0.00
0.06
estimate
0.80
140
558
35
46
7.96
25.27
1.9
1.3
—
—
—
0
0
204
991
2.50
24.61
3.3
2.5
11.09
13.14
umol/l
4.62
193
920
182
847
2.56
23.97
3.1
2.5
19.83
22.54
%
1.93
171
798
386
2486
2.26
23.91
7.4
3.7
0.01
0.03
estimate
0.62
138
562
152
661
2.67
22.90
2.8
2.7
1.72
1.84
%
0.74
137
599
50
105
5.06
22.80
5.1
3.0
3.84
4.29
e9/l
0.73
50
105
58
138
4.50
22.77
5.0
2.8
59.46
59.54
%
0.01
58
138
320
1942
2.21
22.57
5.1
3.1
26.50
91.69
e6/l
1.14
277
1472
221
1157
2.34
22.23
5.0
2.7
502.55
520.37
mosm/kgh2o
0.65
202
1015
286
1673
2.21
21.96
4.7
3.0
0.22
0.45
e6/l
2.76
244
1211
70
197
3.84
21.96
2.0
2.5
13.04
10.82
g/l
1.66
65
179
108
401
3.01
21.84
2.9
3.1
87.77
198.07
ng/l
5.45
100
369
124
501
2.80
21.46
2.6
2.7
66.35
73.06
e9/l
1.23
91
372
120
477
2.84
21.41
1.3
1.4
—
—
—
0
0
305
1852
2.16
21.10
4.3
4.0
7.39
7.40
ph
2.23
243
1302
263
1511
2.20
20.90
2.9
2.7
329.36
330.23
umol/l
0.05
245
1333
61
164
3.98
20.38
1.4
1.2
156.00
83.50
titre
—
5
20
80
260
3.35
20.18
2.5
2.0
1.56
1.47
g/l
0.30
73
232
350
2275
2.09
19.89
5.0
3.6
24.89
51.56
ng/l
1.00
263
1552
453
3250
2.15
19.70
6.8
6.1
9.49
10.69
umol/l
2.70
432
3101
393
2679
2.09
19.51
6.2
4.7
34.90
35.91
g/l
3.00
379
2526
271
1631
2.09
18.62
3.2
2.2
3.15
2.88
mg/l
1.09
241
1408
80
277
3.14
18.15
1.3
1.3
—
—
—
0
0
168
855
2.28
17.52
2.4
2.0
—
—
—
0
0
27
17
16.47
17.14
2.1
1.4
9.36
8.68
ug/l
0.25
27
17
191
1038
2.16
16.87
1.6
1.7
—
—
—
0
0
173
904
2.22
16.86
1.3
1.2
—
—
—
0
0
33
66
5.20
15.87
1.8
2.7
1.04
1.21
g/24h
0.12
18
43
381
2707
1.91
15.31
18.4
12.5
1.26
1.20
inr
1.10
312
2238
28
51
5.68
14.88
2.2
1.5
47.81
60.31
%
0.77
21
36
139
698
2.24
14.75
2.2
1.6
—
—
—
0
0
292
1940
1.88
14.09
3.3
2.4
57.53
62.74
u/l
0.71
275
1810
104
477
2.39
13.57
3.9
3.7
1.22
1.23
mmol/l
1.02
92
415
47
141
3.50
13.38
1.7
1.6
7003.78
14869.29
e6/l
0.78
32
100
22
36
6.28
13.00
2.9
2.9
56.88
42.14
%
—
8
18
40
110
3.80
12.93
1.4
1.5
—
—
—
0
0
228
1433
1.88
12.83
2.0
1.7
1.02
1.15
mg/l
0.46
202
1129
506
4067
1.92
12.65
6.2
4.6
651.33
3205.22
e6/l
—
6
63
277
1857
1.82
12.64
11.2
5.9
—
—
—
0
0
43
127
3.54
12.53
1.3
1.8
—
—
—
0
0
153
846
2.04
12.49
2.3
2.3
217.03
115.47
ug/g
1.11
125
666
19
12
16.23
12.19
2.4
2.3
28.68
28.92
%
0.02
19
12
174
1021
1.94
11.94
1.9
1.7
998.53
1171.06
nmol/l
1.95
134
771
21
36
5.99
11.85
2.0
1.5
49.25
42.38
%
0.26
13
24
173
1023
1.92
11.56
4.0
2.8
1.25
1.12
e6/l
0.13
115
514
59
222
2.81
11.50
1.9
1.9
2.33
2.48
ug/l
0.03
53
200
52
183
2.99
11.43
1.9
4.4
45.70
74.55
mg/l
0.42
46
158
52
183
2.99
11.43
1.9
4.4
40.46
57.07
mg/l
0.38
45
158
22
41
5.51
11.41
1.7
1.1
197.27
74.00
titre
—
11
5
265
1804
1.76
11.14
1.8
1.7
20.64
20.90
nmol/l
0.09
220
1528
23
28
8.46
10.88
1.8
2.0
317.60
453.14
e6/l
0.69
15
22
112
583
2.10
10.65
2.9
2.2
0.21
0.22
g/l
0.30
103
550
235
1564
1.76
10.57
1.4
1.3
0.97
1.95
u/ml
1.21
56
401
402
3105
1.71
10.46
4.2
3.1
133.29
102.60
ug/l
0.89
375
2908
34
97
3.64
10.44
1.4
1.5
158.73
157.24
au/ml
0.03
11
28
19
18
10.82
10.32
1.3
1.2
26.11
26.83
s
0.27
19
18
29
75
3.99
10.21
3.5
2.8
—
—
—
0
0
191
1210
1.80
10.09
1.7
1.9
—
—
—
0
0
29
77
3.89
9.86
1.3
1.2
—
—
—
0
0
156
936
1.86
9.80
4.8
2.9
4.92
3.55
e6/l
0.41
96
426
46
165
2.92
9.79
2.0
4.2
1.30
2.81
ratio
1.66
24
89
133
758
1.94
9.78
1.9
1.4
—
—
—
0
0
35
107
3.39
9.70
1.1
1.4
292.57
256.03
u/ml
0.25
21
56
95
486
2.11
9.41
3.5
4.0
93.38
84.25
ng/l
0.22
85
427
109
592
2.00
9.18
5.7
4.1
7.38
7.35
ph
0.59
87
423
85
421
2.16
9.15
2.3
2.4
26.82
21.01
au/ml
—
6
36
437
3520
1.66
9.09
5.9
4.8
6.37
6.60
mmol/l
1.57
423
3327
24
59
4.18
9.04
2.4
4.4
—
—
—
0
0
131
762
1.89
9.01
6.7
5.4
1.03
1.04
mmol/l
0.28
123
701
39
135
3.00
8.84
2.4
2.0
133.39
129.57
g/l
0.41
28
103
288
2111
1.63
8.61
4.3
3.0
32.51
29.60
u/l
1.27
276
1995
352
2712
1.61
8.54
2.4
2.1
95.73
96.60
pmol/l
0.13
198
1381
38
135
2.92
8.24
1.2
1.2
—
—
—
0
0
106
596
1.92
8.04
4.3
3.4
7.39
7.39
ph
0.24
68
331
47
190
2.58
8.00
1.1
1.3
—
—
—
0
0
102
571
1.92
7.83
4.5
3.3
1.95
1.87
mmol/l
0.08
92
490
646
5932
2.43
7.68
35.3
14.6
17.46
22.47
mg/l
5.70
599
4857
13
11
12.02
7.60
1.1
1.1
—
—
—
0
0
12
9
13.54
7.40
1.0
1.1
—
—
—
0
0
270
2011
1.56
7.21
4.1
3.0
—
—
—
0
0
81
434
1.98
7.05
1.3
1.2
63.32
227.42
u/ml
1.75
70
405
60
289
2.18
6.92
6.3
3.4
1.02
1.02
ratio
0.10
55
274
45
195
2.40
6.64
1.5
1.4
308.49
292.97
ug/g
0.18
27
113
207
1476
1.58
6.57
7.4
3.8
7.30
1.02
kg/l
0.50
161
982
288
2210
1.52
6.55
3.3
3.3
2.33
2.36
mmol/l
2.34
262
2006
89
505
1.88
6.54
6.1
3.7
—
—
—
0
0
18
47
3.91
6.29
1.3
1.2
—
—
—
0
0
36
144
2.58
6.29
6.8
4.3
—
—
—
0
0
28
98
2.94
6.27
1.1
1.1
—
—
—
0
0
44
196
2.33
6.12
3.0
3.1
772.47
287.46
mg/l
0.91
19
78
47
217
2.25
6.03
2.6
1.9
20.76
20.54
s
0.08
42
197
118
746
1.70
6.01
1.4
1.3
—
—
—
0
0
178
1249
1.57
5.98
1.7
1.7
50725069.89
42709750.54
pmol/l
0.05
138
1063
22
69
3.26
5.91
3.6
2.6
—
—
—
0
0
91
537
1.80
5.89
1.5
1.4
—
—
—
0
0
26
92
2.90
5.73
1.2
1.0
—
—
—
0
0
14
23
6.19
5.71
4.6
3.9
2179.71
1221.35
u/ml
0.48
14
23
13
20
6.60
5.57
1.9
1.4
2.40
1.83
%
—
5
6
31
123
2.59
5.53
1.7
2.2
4.69
4.67
mmol/24h
0.01
25
106
21
67
3.20
5.50
1.6
1.0
—
—
—
0
0
102
635
1.71
5.48
6.6
8.4
0.55
0.99
mmol/l
0.47
89
528
18
52
3.53
5.48
1.2
1.2
—
—
—
0
0
103
645
1.70
5.42
6.6
8.4
7.44
7.41
ph
2.52
59
364
22
73
3.08
5.42
1.1
1.1
1.53
1.47
g/l
0.46
22
68
28
110
2.61
5.10
3.7
3.3
—
—
—
0
0
8
6
13.47
5.09
1.1
1.0
—
—
—
0
0
66
369
1.87
5.08
4.5
3.6
7.41
7.42
ph
0.60
55
310
11
16
6.97
4.96
1.5
1.4
—
—
—
0
0
146
1022
1.54
4.87
3.6
3.1
0.80
0.82
mmol/l
1.63
135
967
15
42
3.63
4.79
2.3
2.8
1851.73
733.88
mg
0.74
15
42
11
17
6.56
4.78
1.5
1.2
35.17
39.24
g/l
—
6
10
107
708
1.61
4.54
2.2
2.5
6.73
6.91
umol/l
0.05
94
621
87
551
1.66
4.39
1.3
1.2
—
—
—
0
0
17
55
3.14
4.38
1.1
1.1
—
—
—
0
0
15
45
3.39
4.34
1.1
1.0
270.53
299.15
mg/l
0.75
15
40
311
2561
1.39
4.33
2.2
2.1
—
—
—
0
0
60
345
1.81
4.25
3.7
3.1
24.48
24.26
mmol/l
0.24
60
340
48
263
1.89
3.97
4.8
3.6
—
—
—
0
0
25
106
2.41
3.95
1.2
1.5
—
—
—
0
0
44
235
1.93
3.92
3.6
7.0
0.89
0.88
%
0.05
44
221
345
2920
1.36
3.92
3.1
2.7
—
—
estimate
—
0
0
252
2029
1.38
3.92
3.0
2.3
—
—
—
0
0
15
49
3.11
3.82
1.2
1.4
—
—
—
0
0
51
291
1.81
3.73
2.6
2.3
—
—
—
0
0
76
486
1.63
3.70
9.0
8.1
—
—
—
0
0
18
67
2.73
3.68
4.8
2.4
1.21
1.20
mmol/l
0.39
18
67
74
471
1.64
3.67
4.5
2.5
6.19
6.14
ph
0.13
45
317
18
68
2.69
3.59
4.8
2.4
4.06
4.00
mmol/l
0.21
18
68
18
68
2.69
3.59
4.8
2.4
107.00
105.88
mmol/l
0.65
18
68
19
74
2.61
3.57
1.6
1.3
—
—
—
0
0
19
74
2.61
3.57
1.6
1.3
—
—
—
0
0
19
74
2.61
3.57
1.6
1.3
—
—
—
0
0
19
74
2.61
3.57
1.6
1.3
—
—
—
0
0
10
21
4.82
3.56
1.1
1.4
—
—
—
0
0
72
460
1.63
3.53
2.4
2.3
6.83
7.23
ug/l
0.08
55
403
6
6
10.07
3.50
1.2
1.2
—
—
—
0
0
29
141
2.10
3.37
2.2
3.1
1.38
1.70
index
0.15
13
74
45
256
1.81
3.34
1.0
1.1
—
—
—
0
0
194
1533
1.37
3.29
2.7
2.3
—
—
—
0
0
21
90
2.38
3.27
1.4
1.4
—
—
—
0
0
149
1130
1.41
3.23
4.7
3.9
278.69
297.04
ng/l
0.04
118
836
16
62
2.62
3.06
1.6
2.1
0.63
0.67
mmol/l
0.02
16
62
17
68
2.54
3.06
1.5
1.7
15.47
28.28
ng/l
1.58
17
68
80
543
1.54
3.05
7.8
9.2
118.34
120.43
g/l
0.39
80
533
534
4928
1.37
3.00
5.7
4.6
14.87
14.72
pmol/l
0.76
493
4548
12
37
3.28
2.94
1.2
1.0
—
—
—
0
0
53
329
1.66
2.93
1.3
1.3
—
—
—
0
0
15
58
2.62
2.89
1.0
1.3
—
—
—
0
0
17
71
2.43
2.82
1.1
1.1
—
—
—
0
0
651
6257
1.73
2.81
38.6
19.3
74.20
73.43
umol/l
0.24
645
6184
7
14
5.04
2.73
6.0
4.5
63.57
46.71
%
—
7
14
16
66
2.46
2.72
2.1
2.6
34.76
17.82
iu/ml
—
5
5
35
589
0.57
2.69
1.3
1.4
—
—
—
0
0
629
6009
1.54
2.62
27.8
17.4
139.29
139.66
mmol/l
2.85
619
5895
10
30
3.37
2.61
1.1
1.7
—
—
—
0
0
158
1257
1.33
2.51
2.8
2.6
2.46
2.45
mmol/l
0.38
141
1137
629
6020
1.52
2.47
27.9
17.5
3.94
3.95
mmol/l
0.50
616
5886
87
629
1.44
2.46
1.7
1.5
—
—
—
0
0
11
38
2.92
2.42
1.7
1.1
14.82
12.48
u/l
0.20
11
33
646
6223
1.61
2.41
29.0
11.6
25.57
24.60
u/l
1.05
637
6057
456
4168
1.28
2.40
5.0
4.0
—
0.00
—
0
5
29
161
1.84
2.39
1.2
1.2
—
—
—
0
0
14
58
2.44
2.38
1.3
1.3
—
—
—
0
0
6
13
4.65
2.27
5.2
1.7
—
—
—
0
0
6
13
4.65
2.27
4.3
1.3
6.05
9.88
mmol/l
—
6
13
9
29
3.13
2.23
1.2
1.2
—
—
—
0
0
47
305
1.58
2.23
10.5
11.3
15.62
15.72
%
0.09
47
295
34
203
1.71
2.22
5.3
3.9
24.56
24.99
mmol/l
0.38
29
192
5
9
5.59
2.21
1.0
1.0
—
—
—
0
0
8
24
3.36
2.18
51.6
25.6
6.66
6.95
ug/l
—
8
19
14
61
2.32
2.16
1.4
2.6
—
—
—
0
0
6
15
4.03
2.04
1.0
1.1
—
—
—
0
0
5
11
4.57
1.94
1.0
1.1
0.03
0.02
u/ml
—
5
11
8
27
2.99
1.94
1.1
1.1
—
—
—
0
0
58
409
1.46
1.91
2.8
3.5
4.34
4.51
pmol/l
0.49
51
360
12
52
2.33
1.88
1.2
1.1
87.08
112.44
pmol/l
1.09
12
52
48
328
1.50
1.85
1.1
1.1
—
154.56
—
0
9
28
168
1.69
1.83
2.0
1.3
650.14
477.85
mg/l
0.78
28
161
227
1961
1.23
1.82
5.0
4.1
14.10
8.67
mg/mmol
0.48
147
1200
5
12
4.19
1.82
1.0
1.2
—
—
—
0
0
5
12
4.19
1.82
1.0
1.1
—
—
—
0
0
445
4119
1.23
1.80
4.6
3.2
51.44
45.36
u/l
0.74
420
3888
8
29
2.78
1.79
1.9
2.4
14.79
17.35
%
—
8
29
632
6112
1.41
1.73
25.0
13.4
—
—
—
0
0
5
13
3.87
1.72
1.0
1.0
—
—
—
0
0
11
49
2.27
1.64
1.7
1.3
6183.33
50444.71
e6/l
—
6
24
13
63
2.08
1.60
1.5
1.8
10.02
11.10
%
0.37
13
63
18
99
1.84
1.58
1.2
1.2
—
—
—
0
0
7
26
2.71
1.58
1.0
1.5
109.86
157.56
mmol/24h
—
7
26
22
129
1.73
1.58
2.0
1.2
—
—
—
0
0
53
716
0.72
1.52
1.8
1.8
—
—
—
0
0
5
15
3.35
1.52
1.0
2.5
37.76
42.98
g/l
—
5
15
12
59
2.05
1.44
1.8
1.7
—
—
—
0
0
6
22
2.74
1.43
1.2
1.0
—
—
—
0
0
9
40
2.27
1.40
1.3
1.1
—
—
—
0
0
23
142
1.64
1.40
2.1
1.1
5.76
15.59
e6/l
0.72
17
108
21
335
0.62
1.40
1.1
1.1
—
—
—
0
0
27
174
1.57
1.39
1.8
1.9
3.17
37.80
iu/l
—
10
69
15
82
1.85
1.36
1.0
1.2
—
—
—
0
0
35
497
0.69
1.35
1.9
1.8
3.48
3.43
mmol/l
0.08
21
362
6
24
2.51
1.30
2.0
1.3
—
—
—
0
0
66
512
1.32
1.29
1.2
1.2
61.29
130.70
u/ml
2.17
23
216
40
286
1.42
1.28
1.9
1.9
—
—
—
0
0
75
594
1.29
1.27
2.4
2.4
32.19
38.12
u/l
0.69
63
480
6
25
2.41
1.24
1.8
2.2
—
—
—
0
0
12
214
0.55
1.23
1.8
1.3
—
—
—
0
0
10
49
2.06
1.22
1.5
1.3
—
—
—
0
0
8
37
2.18
1.21
1.0
1.1
2196.38
1539.19
miu/ml
—
8
37
6
26
2.32
1.19
1.8
1.7
61.95
46.79
ug/l
—
6
26
8
38
2.12
1.18
2.9
1.5
0.76
1.40
promille
—
8
29
8
38
2.12
1.18
1.1
1.3
—
—
—
0
0
12
64
1.89
1.18
1.2
1.2
—
—
—
0
0
15
87
1.74
1.16
1.1
1.2
—
—
—
0
0
5
20
2.51
1.15
5.6
3.8
—
—
—
0
0
216
1931
1.17
1.15
4.0
3.4
97.36
45.50
mg/l
0.85
131
1219
14
80
1.77
1.13
1.2
1.4
415.50
361.96
pmol/l
0.17
14
71
229
2059
1.17
1.13
4.2
3.3
6.62
7.21
mmol/l
1.24
190
1748
7
30
2.35
1.12
1.3
1.2
—
93.00
%
—
0
5
7
34
2.07
1.03
1.9
2.6
5.91
8.33
mmol/l
—
7
34
10
53
1.90
1.01
1.5
1.4
—
—
—
0
0
236
2585
0.87
1.00
1.9
1.9
1.38
1.34
mmol/l
0.30
196
2208
12
197
0.60
0.95
1.5
1.3
76.50
278.19
pmol/l
1.48
12
192
18
117
1.55
0.94
1.8
1.3
0.94
0.89
nmol/l
0.15
13
94
6
28
2.15
0.91
1.0
1.2
22.50
7.79
mm/h
—
6
28
6
28
2.15
0.91
2.8
3.3
0.50
0.93
index
—
6
28
6
30
2.01
0.87
2.8
2.4
—
—
—
0
0
5
24
2.09
0.74
5.6
3.4
—
—
—
0
0
25
186
1.36
0.71
1.8
2.5
—
—
—
0
0
13
193
0.67
0.70
1.9
1.7
—
—
—
0
0
51
613
0.82
0.68
2.3
3.2
0.95
0.80
ug/l
0.25
30
396
652
6433
1.25
0.64
48.9
22.9
254.48
255.57
e9/l
0.16
646
6319
25
191
1.32
0.61
1.3
1.2
—
—
—
0
0
8
50
1.61
0.61
1.4
1.1
—
—
—
0
0
652
6436
1.24
0.61
48.5
22.8
30.25
30.25
pg
0.01
647
6373
652
6436
1.24
0.61
48.7
22.8
4.34
4.45
e12/l
7.47
645
6303
652
6437
1.24
0.60
48.8
22.9
6.38
6.66
e9/l
2.63
644
6301
652
6438
1.24
0.59
49.2
23.0
130.08
133.65
g/l
9.34
647
6371
10
64
1.57
0.59
1.5
1.3
5.44
6.15
mmol/l
—
10
59
224
2389
0.91
0.56
3.2
3.1
—
—
—
0
0
10
65
1.55
0.55
1.6
1.1
—
—
—
0
0
6
37
1.63
0.55
1.0
2.1
78.50
124.99
ng/l
—
6
37
9
65
1.39
0.50
2.2
1.9
86.39
90.02
%
—
9
65
587
5965
0.89
0.47
5.7
5.7
2.55
2.75
mmol/l
7.81
553
5565
568
5580
1.10
0.42
6.5
6.2
38.37
38.87
mmol/mol
0.80
536
5244
0
16
0.00
0.41
0.0
1.1
—
0.70
—
0
9
0
16
0.00
0.41
0.0
3.4
—
—
—
0
0
578
5685
1.10
0.41
7.3
5.7
1.99
1.88
mu/l
0.89
543
5290
8
59
1.36
0.41
2.1
1.8
—
—
—
0
0
8
59
1.36
0.41
1.0
1.2
—
—
—
0
0
12
88
1.37
0.40
1.2
1.3
54.22
68.43
mu/l
0.18
12
83
8
61
1.32
0.39
1.4
1.5
—
—
—
0
0
5
37
1.35
0.37
1.2
2.2
745.60
534.95
ml
—
5
22
6
86
0.70
0.33
1.2
1.3
271.00
274.41
mosm/kgh2o
—
6
68
13
165
0.78
0.32
1.3
1.1
—
—
—
0
0
7
52
1.35
0.31
2.6
2.6
—
—
—
0
0
29
335
0.86
0.30
1.6
1.6
1017.18
947.96
mu/l
0.14
23
281
89
825
1.09
0.30
1.3
1.3
—
—
—
0
0
15
121
1.25
0.28
2.3
1.8
—
—
—
0
0
12
151
0.79
0.28
1.8
1.5
—
—
—
0
0
22
257
0.85
0.26
1.0
1.6
0.57
0.32
mg/l
—
6
112
5
75
0.66
0.26
3.2
2.4
—
—
—
0
0
580
5861
0.93
0.24
5.3
4.9
1.50
1.52
mmol/l
0.48
546
5459
6
82
0.73
0.24
1.3
1.3
—
—
—
0
0
16
190
0.84
0.23
27.9
8.9
—
—
—
0
0
16
190
0.84
0.23
1.3
1.5
—
—
—
0
0
5
41
1.22
0.22
1.2
1.3
81.20
75.02
umol/l
—
5
41
0
11
0.00
0.21
0.0
1.0
—
7.50
—
0
11
0
10
0.00
0.21
0.0
1.3
—
1.72
—
0
10
0
12
0.00
0.21
0.0
1.1
—
0.02
—
0
12
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
14
165
0.85
0.19
1.4
1.8
—
—
—
0
0
14
119
1.18
0.18
1.1
1.1
—
—
—
0
0
584
5887
0.95
0.17
5.3
5.0
4.49
4.71
mmol/l
7.39
549
5511
7
61
1.15
0.17
3.7
9.7
6.49
6.81
mmol/l
—
7
48
25
275
0.91
0.14
1.7
2.1
118.44
3949.89
u/l
—
9
112
21
233
0.90
0.14
1.2
1.5
—
—
—
0
0
25
228
1.10
0.13
1.3
3.3
27.47
1075.33
u/ml
1.03
19
197
36
386
0.93
0.13
1.2
1.3
37.00
28.67
iu/l
0.59
28
330
67
699
0.95
0.11
1.5
1.5
—
—
—
0
0
14
156
0.90
0.10
1.8
1.6
—
—
—
0
0
15
166
0.90
0.10
1.4
1.2
—
—
—
0
0
22
236
0.93
0.08
1.2
1.5
—
—
—
0
0
8
94
0.85
0.06
1.3
1.3
0.48
19.67
nmol/l
—
8
89
182
1794
1.02
0.06
1.5
1.5
—
—
—
0
0
13
119
1.09
0.06
1.1
1.1
—
—
—
0
0
22
233
0.94
0.06
1.3
1.5
—
—
—
0
0
64
623
1.03
0.05
3.0
4.1
3.89
16.97
ug/l
1.20
55
510
21
222
0.94
0.05
1.2
1.5
—
—
—
0
0
22
232
0.95
0.05
1.2
1.5
—
—
—
0
0
13
120
1.08
0.05
2.8
3.9
19.50
30.62
mg/l
—
6
84
45
464
0.97
0.04
1.3
1.2
—
—
—
0
0
556
5577
0.98
0.04
4.6
4.2
1.27
1.26
mmol/l
0.19
518
5145
103
1016
1.02
0.03
4.4
5.5
1.27
2.34
ug/l
2.45
88
910
23
239
0.96
0.02
1.1
1.3
366.80
258.00
miu/ml
—
8
116
35
359
0.97
0.02
1.8
1.6
—
—
—
0
0
573
5737
0.99
0.01
5.3
5.0
5.61
5.87
mmol/l
6.43
526
5297
13
124
1.05
0.00
1.9
2.3
729.43
109.52
ug/min
—
7
71
31
304
1.02
0.00
1.8
2.2
12.48
12.63
nmol/l
0.03
26
282
23
225
1.02
0.00
1.3
1.2
1.51
1.59
g/l
0.76
23
225
23
233
0.99
0.00
1.3
1.2
0.84
0.90
g/l
0.65
23
233
10
102
0.98
0.00
1.2
1.6
—
—
—
0
0
69
686
1.01
0.00
1.6
1.7
—
—
—
0
0
13
131
0.99
0.00
1.3
1.1
0.68
2.44
u/ml
—
5
67
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
4.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
40.00
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
252.60
—
0
5
8
81
0.99
-0.00
1.3
1.3
0.19
0.18
nmol/l
—
8
55
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
330.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
57.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
11
110
1.00
-0.00
1.2
1.0
1.02
4.62
u/ml
—
6
56
8
81
0.99
-0.00
1.5
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: M13_MCTD – Mixed connective tissue disease

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).