Amblyopia ex anopsia

H7_AMBLYANOPSIA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H53.0
  • Hospital discharge: ICD-9 3680A
  • Hospital discharge: ICD-8 37720
  • Cause of death: ICD-10 H53.0
  • Cause of death: ICD-9 3680A
  • Cause of death: ICD-8 37720

2 out of 7 registries used, show all original rules.

1867

4. Check minimum number of events

None

1867

5. Include endpoints

None

1867

6. Filter based on genotype QC (FinnGen only)

1667

Control definitions (FinnGen only)

Control exclude
H7_VISUALDISTBLIND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H53
Name in latin
Amblyopia ex anopsia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 31190 15645 15478
Only index persons 23884 12205 11679
Unadjusted period prevalence (%)
Whole population 0.44 0.45 0.43
Only index persons 0.45 0.45 0.45
Median age at first event (years)
Whole population 6.33 6.37 6.15
Only index persons 6.77 6.98 6.55

-FinnGen-

Key figures

All Female Male
Number of individuals 1667 1034 633
Unadjusted period prevalence (%) 0.34 0.37 0.29
Median age at first event (years) 22.26 15.70 32.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1753
Matched controls
17529
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H53.0
ICD-10 Finland
Amblyopia ex anopsia
6296.5
307.7
1444
13
H50.0
ICD-10 Finland
Convergent concomitant strabismus
28.3
266.7
183
72
37720
ICD-8 Finland
Other diseases of retina and optic nerve, Amblyopia
+∞
253.4
237
*
H52.0
ICD-10 Finland
Hypermetropia
13.5
248.1
246
209
37300
ICD-8 Finland
Strabismus, Concomitans convergens
50.2
217.1
126
27
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
29.4
209.5
141
52
H50.1
ICD-10 Finland
Divergent concomitant strabismus
33.3
192.1
124
40
H50.30
ICD-10 Finland
Intermittent esotropy
21.5
122.2
92
45
3680A
ICD-9 Finland
Visual disturbances, Amblyopia ex anopsia
+∞
114.9
109
*
H52.2
ICD-10 Finland
Astigmatism
8.1
111.6
157
211
H53.1
ICD-10 Finland
Subjective visual disturbances
8.3
107.1
146
189
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
19.0
106.8
85
47
H50.31
ICD-10 Finland
Intermittent exotropia
10.2
81.0
93
96
XCK00
NOMESCO Finland
Perimetry
5.6
79.2
157
300
37301
ICD-8 Finland
Strabismus, Concomitans divergens
16.4
76.4
65
41
H53.2
ICD-10 Finland
Diplopia
20.0
74.9
58
30
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.9
74.3
446
1848
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.2
63.9
284
986
H54.5
ICD-10 Finland
Severe visual impairment, monocular
26.2
59.0
41
16
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.4
57.4
232
757
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.3
47.2
197
653
H54.7
ICD-10 Finland
Unspecified visual loss
17.3
47.2
39
23
H53.4
ICD-10 Finland
Visual field defects
68.8
41.2
47
7
H52.1
ICD-10 Finland
Myopia
3.8
40.8
132
370
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.2
40.5
462
2489
H53.9
ICD-10 Finland
Visual disturbance, unspecified
5.6
36.9
71
131
H50.2
ICD-10 Finland
Vertical strabismus
12.2
36.8
37
31
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.0
34.3
516
3049
H25.8
ICD-10 Finland
Other senile cataract
2.9
34.1
177
662
37001
ICD-8 Finland
Refractive errors, Hypermetropia. Hyperopia
343.6
34.0
34
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.3
31.9
127
407
3780A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONCOMITANS CONVERGENS]
89.3
31.8
35
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
30.8
161
603
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.9
29.1
141
507
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
10.2
27.4
31
31
CEC00
NOMESCO Finland
Recession of extraocular muscle
30.6
27.3
36
12
H50.52
ICD-10 Finland
Exophoria
5.4
26.9
53
100
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
26.7
175
735
H50.51
ICD-10 Finland
Esophoria
8.8
25.4
32
37
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
36.2
25.2
32
9
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.4
25.1
190
851
H26.4
ICD-10 Finland
After-cataract
2.5
22.9
154
653
H25.0
ICD-10 Finland
Senile incipient cataract
3.1
22.6
99
336
XCK10
NOMESCO Finland
Photography of fundus of eye
2.4
21.1
150
652
37003
ICD-8 Finland
Refractive errors, Anisometropia
+∞
20.9
20
*
H25.1
ICD-10 Finland
Senile nuclear cataract
1.8
20.4
343
2057
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
20.3
178
848
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
3.0
19.4
89
310
3503
FHL
Single muscle retroposition
15.0
18.9
31
21
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
7.2
18.2
27
38
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
17.7
160
770
XCD10
NOMESCO Finland
Electrophysiological examination of eye
4.2
17.6
47
115
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
17.2
370
2370
3671A
ICD-9 Finland
Disorders of refraction and accommodation, Myopia
+∞
16.7
16
*
SPAT1263
SPAT
Sampling
1.5
16.5
733
5586
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
16.4
194
1033
3781A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS CONCOMITANS DIVERGENS]
60.6
15.8
18
*
Q12.0
ICD-10 Finland
Congenital cataract
26.5
15.6
21
8
ZXA10
NOMESCO Finland
Bilateral
1.7
15.6
297
1836
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.5
15.5
99
410
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
15.0
582
4284
Z31.5
ICD-10 Finland
Genetic counselling
2.3
14.9
120
551
XA800
NOMESCO Finland
Neuropsychological investigation
2.5
14.8
98
413
CEC30
NOMESCO Finland
Resection of extraocular muscle
36.3
14.4
18
5
H47.2
ICD-10 Finland
Optic atrophy
22.5
14.2
20
9
P85
ICPC
Mental retardation
5.4
14.2
28
53
H33.0
ICD-10 Finland
Retinal detachment with retinal break
3.3
13.9
51
156
3505
FHL
Single muscle resection
53.8
13.8
16
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
6.3
13.8
23
37
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.4
13.6
97
422
R51.80
ICD-10 Finland
Headache
1.7
13.6
308
1991
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
13.6
233
1395
H53.3
ICD-10 Finland
Other disorders of binocular vision
16.3
13.5
21
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
13.2
672
5197
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.3
13.0
49
152
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
12.6
162
886
H26.02
ICD-10 Finland
Presenil cataract
3.4
12.5
44
131
WX140
NOMESCO Finland
Parabulbar anesthesy
2.6
12.3
70
274
H50.9
ICD-10 Finland
Strabismus, unspecified
9.0
12.2
25
28
SPAT1301
SPAT
No procedures
1.5
12.1
513
3810
3507
FHL
Retroposition and resection
16.0
12.1
19
12
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.7
12.1
242
1511
H44.2
ICD-10 Finland
Degenerative myopia
21.4
12.0
17
8
37929
ICD-8 Finland
Blindness, one eye, specifically defined
65.4
11.6
13
*
H40.0
ICD-10 Finland
Glaucoma suspect
2.1
11.4
106
516
WX704
NOMESCO Finland
Intubation
2.0
11.0
129
683
RL140, ,
NOMESCO Finland
5.8
11.0
20
35
S01EC01
ATC
acetazolamide; systemic
3.5
10.7
36
104
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
4.6
10.7
25
55
CEW99
NOMESCO Finland
Other operation on extraocular muscle
60.4
10.6
12
*
CEC20
NOMESCO Finland
Recession and advancement of extraocular muscle
60.4
10.6
12
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
3.6
10.6
35
100
ZXA05
NOMESCO Finland
Left side
1.6
10.6
308
2105
N03AX14
ATC
levetiracetam; systemic
2.7
10.6
55
206
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.4
10.6
859
7141
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.9
10.4
126
676
SPAT1262
SPAT
Handing over of treatment supplies
1.7
10.3
224
1428
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
10.2
401
2923
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.7
10.0
54
207
S01ED01
ATC
timolol; ophthalmic
2.8
9.7
48
175
S01ED51
ATC
timolol, combinations; ophthalmic
2.0
9.7
97
487
CEC50
NOMESCO Finland
Advancement of extraocular muscle
55.3
9.7
11
*
114
Kela drug reimbursment
Glaucoma
2.0
9.6
104
537
H26.2
ICD-10 Finland
Complicated cataract
4.5
9.6
23
52
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.2
9.5
37
118
R62.0
ICD-10 Finland
Delayed milestone
2.8
9.5
45
161
SPAT1216
SPAT
Assessment of functional ability
1.7
9.4
200
1265
XCH00
NOMESCO Finland
Eye pressure measurement
2.4
9.4
65
280
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.8
9.4
47
173
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
9.4
1240
11077
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.0
9.3
98
500
N02BF01
ATC
gabapentin; oral
1.8
9.3
146
850
N03AG01
ATC
valproic acid; systemic, rectal
2.0
9.3
96
487
H27.0
ICD-10 Finland
Aphakia
10.7
9.3
17
16
ZXA00
NOMESCO Finland
Right side
1.5
9.3
333
2377
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
9.2
396
2929
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
13.7
9.2
15
11
Z2445
NOMESCO Finland
Psychologist
1.9
9.1
109
582
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
5.0
9.1
19
38
Q21.10
ICD-10 Finland
Persistent ostium secundum
3.8
9.1
27
72
AA1AD
NOMESCO Finland
CT of head and brain
1.5
9.1
348
2517
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.4
9.0
61
261
F95
ICPC
Strabismus
18.7
8.9
13
7
SPAT1312
SPAT
General health counselling
1.4
8.9
586
4666
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.0
8.7
95
491
F83
ICD-10 Finland
Mixed specific developmental disorders
2.8
8.7
42
152
H57.1
ICD-10 Finland
Ocular pain
2.2
8.6
72
337
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.6
8.6
50
199
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
4.8
8.6
19
40
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
27.6
8.5
11
*
37000
ICD-8 Finland
Refractive errors, Astigmatismus
+∞
8.3
8
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.0
8.3
35
117
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.3
8.3
64
290
SFA10
NOMESCO Finland
One-surface restoration
1.3
8.2
945
8173
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
17.2
8.1
12
7
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
8.0
317
2300
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
8.0
257
1788
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.6
8.0
200
1318
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
8.0
371
2777
N03AX12
ATC
[U] gabapentin; oral
1.6
7.9
196
1287
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
7.9
597
4841
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
7.9
158
986
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
3.8
7.8
23
61
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.8
7.8
109
614
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
7.8
447
3469
K02.1
ICD-10 Finland
Caries of dentine
1.3
7.8
1022
8978
3768
FHL
Eye examination under general anesthesia
45.2
7.7
9
*
SPAT1153
SPAT
Removal of sutures
1.4
7.7
393
2989
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
2.8
7.6
38
140
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
7.6
201
1340
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
4.0
7.6
21
53
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
7.6
720
6027
N06AX21
ATC
duloxetine; oral
1.6
7.5
163
1036
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
7.5
221
1509
R42
ICD-10 Finland
Dizziness and giddiness
1.5
7.5
304
2215
Z02.7
ICD-10 Finland
Issue of medical certificate
1.8
7.5
121
711
TAB00
NOMESCO Finland
Lumbar puncture
2.1
7.5
72
357
Z2446
NOMESCO Finland
Social worker
1.7
7.5
144
889
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
3.1
7.4
30
98
H01AC01
ATC
somatropin; parenteral
3.1
7.4
30
98
Z97.4
ICD-10 Finland
Presence of external hearing-aid
2.3
7.4
56
252
602
Kela drug reimbursment
Children's severe malnutrition
3.0
7.4
32
109
UKC02
NOMESCO Finland
Cystoscopy
1.6
7.4
172
1113
XCD00
NOMESCO Finland
Clinical examination of eye in general anaesthesia
7.7
7.4
16
21
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
7.4
303
2213
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.7
7.4
142
876
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
2.7
7.4
37
137
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
4.2
7.3
19
46
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
1.9
7.3
91
495
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
2.3
7.2
54
242
N03AX11
ATC
topiramate; oral
2.5
7.2
45
186
G47.3
ICD-10 Finland
Sleep apnoea
1.5
7.2
274
1974
H02.4
ICD-10 Finland
Ptosis of eyelid
2.6
7.1
39
151
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.7
7.1
117
691
Z3231
NOMESCO Finland
Registered nurse
1.4
7.1
422
3286
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
3.8
7.1
21
56
RT150, ,
NOMESCO Finland
4.1
7.1
19
47
H25.2
ICD-10 Finland
Senile cataract, morgagnian type
12.1
7.1
12
10
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.2
7.1
57
264
N05BA09
ATC
clobazam; oral
3.6
7.0
22
61
XF602
NOMESCO Finland
Bloodpressure monitoring
3.1
7.0
28
91
WX400
NOMESCO Finland
Inhalation anesthesy
1.9
7.0
82
436
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
3.4
7.0
24
71
3780B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONVERGENS ALTERNANS]
13.8
6.9
11
8
SPAT1310
SPAT
Counselling related to known health issue
1.3
6.8
513
4136
SPAT1240
SPAT
Therapeutic discussion
1.5
6.8
200
1366
S01FA01
ATC
atropine; ophthalmic
9.3
6.8
13
14
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.1
6.8
59
282
M24.3
ICD-10 Finland
Pathological dislocation and subluxation of joint, not elsewhere classified
40.2
6.8
8
*
S01EA05
ATC
brimonidine; ophthalmic
2.8
6.8
32
115
SXC03
NOMESCO Finland
Other oral or dental procedure
3.7
6.8
21
58
CKC12
NOMESCO Finland
Photocoagulation of retina
2.3
6.7
51
230
E03.89
ICD-10 Finland
Other specified hypothyroidism
2.2
6.7
53
243
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
3.3
6.7
24
73
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
4.0
6.6
18
45
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.6
6.6
142
902
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
6.6
282
2074
F80.8
ICD-10 Finland
Other developmental disorders of speech and language
4.2
6.6
17
41
UDC00
NOMESCO Finland
Ear microscopy
1.7
6.5
121
740
S01EC03
ATC
dorzolamide; ophthalmic
3.5
6.4
21
60
CHC05
NOMESCO Finland
Iridotomy
3.5
6.4
21
60
3673A
ICD-9 Finland
Disorders of refraction and accommodation, Anisometropia and aniseikonia
70.1
6.4
7
*
H54.0
ICD-10 Finland
Blindness, binocular
70.1
6.4
7
*
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.4
6.4
357
2746
G43.3
ICD-10 Finland
Complicated migraine
2.6
6.4
35
136
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2.4
6.4
40
166
ZXE20
NOMESCO Finland
More than three and less than five hours
1.5
6.4
174
1169
N03AX16
ATC
[U] pregabalin
1.4
6.3
267
1957
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.6
6.3
139
888
G91.1
ICD-10 Finland
Obstructive hydrocephalus
6.0
6.3
16
27
3781B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS DIVERGENS ALTERNANS]
11.1
6.3
11
10
XKC03
NOMESCO Finland
Water cystometry
2.5
6.3
39
161
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
1.9
6.3
70
367
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
3.9
6.3
18
47
3672A
ICD-9 Finland
Disorders of refraction and accommodation, Astigmatism
+∞
6.3
6
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
6.2
216
1525
Q14.2
ICD-10 Finland
Congenital malformation of optic disc
26.8
6.2
8
*
N05BA01
ATC
diazepam; systemic, rectal
1.6
6.2
161
1069
R4120
NOMESCO Finland
Occupational therapy
1.8
6.2
97
567
XCW10
NOMESCO Finland
Assessment of vision
3.2
6.2
23
72
SPAT1229
SPAT
Assessment of need for aid
1.8
6.1
81
449
N05AX08
ATC
risperidone; systemic
1.7
6.1
119
737
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
7.7
6.1
13
17
R52.2
ICD-10 Finland
Other chronic pain
2.1
6.1
54
260
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
2.4
6.1
41
176
SFA20
NOMESCO Finland
Two-surface restoration
1.3
6.0
909
8009
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
6.7
6.0
14
21
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.1
6.0
57
282

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
895
7022
1.56
18.24
10.1
8.1
1.22
1.22
mmol/l
0.11
765
6152
776
6014
1.52
15.97
5.6
5.5
36.58
36.41
g/l
0.35
717
5650
619
4670
1.50
13.96
4.0
3.4
40.53
60.09
ng/l
0.53
387
2950
728
5715
1.47
13.29
14.3
12.6
1.23
1.21
inr
0.51
608
4774
84
349
2.48
13.07
1.6
2.4
—
—
—
0
0
789
6310
1.46
12.97
10.3
7.9
1.22
1.22
mmol/l
0.55
730
5885
1218
10594
1.49
12.82
7.9
7.6
83.99
82.96
u/l
0.21
1145
10063
519
3868
1.49
12.06
2.5
2.2
169.20
262.18
u/l
2.16
491
3676
999
8416
1.43
12.04
7.0
5.4
6.52
6.49
mmol/l
0.19
919
7857
561
4287
1.45
11.33
3.0
2.7
61.08
79.68
u/l
0.48
521
3982
90
414
2.24
11.16
1.5
2.2
473.71
467.36
mg/l
0.04
85
396
37
113
3.32
10.15
1.5
1.4
1.86
1.82
mmol/l
0.13
32
106
453
3400
1.45
9.82
3.7
3.5
1654.22
1214.13
ng/l
0.90
381
2866
291
2011
1.54
9.46
1.8
1.7
1211.12
1186.91
nmol/l
0.17
218
1520
850
7137
1.37
9.45
5.8
6.5
11.73
12.68
umol/l
0.68
793
6775
1151
10172
1.38
9.14
5.8
4.4
—
2.55
—
0
13
182
1136
1.67
9.04
6.2
5.2
62.91
77.43
ng/l
3.04
157
1027
79
380
2.13
8.82
1.3
2.2
3.70
3.61
mmol/l
0.35
74
364
1368
12484
1.44
8.77
6.7
5.5
38.25
38.14
mmol/mol
0.16
1282
11794
805
6756
1.35
8.73
3.3
2.7
72.63
73.89
nmol/l
0.61
724
6220
1541
14416
1.57
8.58
20.7
16.0
139.50
139.57
mmol/l
0.62
1508
14099
613
4942
1.37
8.56
3.6
3.4
30.15
31.69
u/l
0.47
581
4688
48
188
2.60
8.53
1.9
2.7
—
—
—
0
0
1304
11835
1.40
8.33
5.0
4.3
14.83
14.65
pmol/l
1.90
1187
10894
1541
14434
1.56
8.33
21.0
16.1
3.96
3.95
mmol/l
1.83
1507
14074
520
4110
1.38
8.13
2.4
2.6
2.77
2.72
mg/l
0.17
445
3578
1470
13651
1.48
8.11
6.1
5.2
1.92
1.87
mu/l
0.64
1371
12810
75
368
2.08
7.98
1.7
2.4
25.23
11.89
e6/l
0.41
56
267
97
522
1.91
7.96
5.6
5.3
1.58
1.56
%
0.09
90
492
75
371
2.07
7.82
1.7
2.4
1962.48
705.65
e6/l
0.57
60
282
591
4793
1.35
7.77
4.1
3.6
7.65
7.91
mmol/l
0.60
496
4186
555
4464
1.36
7.68
3.7
2.9
—
—
—
0
0
334
2470
1.44
7.63
3.4
2.7
13.11
13.60
umol/l
0.65
306
2318
701
5858
1.33
7.44
2.1
2.0
100.18
96.23
pmol/l
1.25
374
3166
298
2167
1.45
7.44
10.1
7.7
1.15
1.13
mmol/l
0.70
275
2029
89
478
1.91
7.37
5.6
5.6
0.88
0.88
%
0.04
83
450
1605
15253
1.62
7.25
16.5
12.1
—
—
—
0
0
489
3886
1.36
7.24
4.5
4.3
10.41
10.00
mg/mmol
0.05
301
2493
498
3970
1.36
7.23
5.0
4.1
7.39
7.40
ph
0.85
356
2832
1615
15377
1.64
7.17
21.0
16.8
74.54
72.46
umol/l
1.31
1596
15184
480
3809
1.36
7.16
3.6
3.6
70.73
56.40
mg/l
0.43
295
2516
1405
13016
1.40
7.15
4.8
4.4
5.85
5.77
mmol/l
1.26
1280
12059
201
1374
1.52
6.80
8.2
6.7
5.10
5.11
kpa
0.08
193
1331
920
8049
1.30
6.77
4.8
3.7
0.00
2.86
estimate
1.07
167
1717
31
111
2.82
6.59
3.1
2.6
—
—
—
0
0
922
8089
1.29
6.55
4.8
3.8
0.07
0.19
estimate
0.29
161
1641
308
2303
1.41
6.55
3.4
2.6
2.44
2.41
g/l
0.41
280
2141
197
1353
1.51
6.52
8.3
6.7
7.41
7.41
ph
0.05
174
1123
226
1601
1.47
6.42
2.5
2.2
367.47
377.71
nmol/l
0.34
209
1492
457
3653
1.34
6.39
4.0
3.7
1.02
1.02
kg/l
0.16
303
2393
283
2093
1.42
6.39
3.5
2.7
21.19
22.82
%
1.31
258
1967
759
6511
1.29
6.34
4.0
3.3
6.28
6.26
ph
0.23
412
3614
58
285
2.07
6.21
4.3
4.3
—
—
—
0
0
1689
16356
1.89
6.03
26.3
21.3
6.86
6.77
e9/l
0.95
1651
15930
1688
16349
1.87
5.93
26.2
21.2
89.73
89.81
fl
0.27
1673
16186
1688
16352
1.87
5.88
27.2
21.7
39.81
40.76
%
1.94
1672
16176
1688
16352
1.87
5.88
26.1
21.1
29.96
29.98
pg
0.24
1673
16187
1688
16353
1.87
5.87
26.2
21.2
4.51
4.53
e12/l
0.77
1649
15939
1688
16359
1.86
5.77
26.5
21.4
134.43
134.99
g/l
0.88
1673
16194
903
7977
1.27
5.76
4.8
3.7
0.00
0.00
estimate
0.50
165
1709
27
98
2.78
5.64
1.1
1.2
0.61
0.55
ratio
0.28
16
57
1078
9748
1.27
5.60
5.7
4.4
2057.82
2413.36
e6/l
0.07
17
131
1686
16345
1.82
5.59
26.3
21.3
258.52
257.11
e9/l
0.39
1653
15970
638
5418
1.28
5.57
7.4
7.4
—
—
—
0
0
447
3629
1.31
5.50
4.0
4.2
—
—
—
0
0
246
1827
1.40
5.40
3.2
3.1
4.75
4.97
e9/l
0.11
200
1625
696
5992
1.27
5.38
4.8
3.6
0.03
0.04
estimate
0.09
143
1422
163
1122
1.50
5.35
4.2
4.2
7.38
7.35
ph
1.69
112
811
470
3859
1.30
5.29
1.8
1.6
20.01
20.02
nmol/l
0.00
389
3324
243
1816
1.39
5.14
1.8
1.7
—
—
—
0
0
236
1763
1.39
5.00
8.8
6.2
1.70
1.55
mmol/l
0.35
202
1481
147
1006
1.50
4.97
2.1
3.1
66.73
66.43
g/l
0.18
133
937
390
3149
1.31
4.93
2.0
2.2
1.40
1.24
mg/l
0.18
279
2369
301
2347
1.34
4.86
6.2
5.2
0.81
0.82
mmol/l
0.47
282
2233
1589
15254
1.45
4.79
12.3
10.9
26.92
25.69
u/l
0.90
1543
14845
114
744
1.57
4.79
1.9
1.8
8.61
7.75
u/l
0.29
85
562
239
1807
1.37
4.71
9.0
6.2
7.37
7.37
ph
0.01
172
1117
58
316
1.86
4.71
6.3
4.2
—
—
—
0
0
64
360
1.81
4.69
5.5
6.5
1.30
1.29
mmol/l
0.05
56
310
177
1273
1.43
4.66
2.7
3.4
65.68
69.06
e9/l
0.64
140
912
336
2679
1.31
4.64
1.7
1.7
33696106.13
23677677.47
pmol/l
0.11
276
2268
1087
9956
1.24
4.53
3.8
3.4
45.51
41.07
u/l
0.62
1024
9466
46
235
1.98
4.52
6.4
7.8
12.39
11.36
mmol/l
0.88
41
210
164
1170
1.44
4.51
10.7
9.5
122.92
121.66
g/l
0.31
158
1145
894
8022
1.23
4.51
3.8
3.3
90.32
92.04
ug/l
0.11
836
7569
96
612
1.60
4.47
5.2
5.0
339.04
337.81
mg/l
0.00
52
349
46
236
1.97
4.47
6.4
7.8
104.44
105.04
mmol/l
0.26
41
211
173
1249
1.43
4.46
10.5
9.3
96.67
95.83
%
1.36
167
1210
224
1693
1.37
4.42
2.6
3.9
1.64
1.69
%
0.28
190
1559
911
8204
1.23
4.39
7.4
7.2
1.99
2.02
e9/l
0.42
813
7225
915
8255
1.23
4.30
7.7
7.6
0.19
0.19
e9/l
0.18
806
7199
1546
14819
1.37
4.26
17.3
14.0
22.29
23.27
mg/l
0.56
1280
11838
888
7997
1.22
4.21
7.4
7.2
0.04
0.04
e9/l
0.15
770
6865
194
1445
1.39
4.19
2.6
3.0
0.21
0.21
g/l
0.08
182
1362
509
4326
1.25
4.17
5.0
3.8
0.00
0.01
estimate
1.54
153
1610
886
7988
1.22
4.12
7.4
7.2
0.57
0.57
e9/l
0.06
769
6847
107
715
1.53
4.09
13.8
11.4
16.12
16.00
%
0.16
101
689
188
1402
1.38
4.04
9.9
8.8
0.18
0.85
mmol/l
1.30
152
1168
136
959
1.45
4.00
9.3
7.3
24.21
24.43
mmol/l
0.48
130
935
137
968
1.45
3.99
3.4
3.5
4.56
4.71
pmol/l
1.05
123
875
548
4718
1.23
3.95
3.2
3.3
2.37
2.36
mmol/l
0.69
482
4322
855
7703
1.21
3.94
7.6
7.3
29.99
29.92
%
0.06
814
7353
142
1017
1.43
3.85
5.7
3.9
1.23
1.23
mmol/l
0.13
123
881
188
1414
1.37
3.84
10.0
8.8
13.39
12.81
kpa
0.77
179
1369
235
1829
1.33
3.83
1.2
1.2
—
—
—
0
0
826
7432
1.21
3.81
7.8
7.4
0.66
0.66
%
0.01
775
7011
15
49
3.08
3.81
1.1
1.3
15.14
17.08
umol/l
1.00
15
43
838
7555
1.21
3.77
7.5
7.2
55.42
55.37
%
0.04
806
7264
267
2121
1.31
3.76
2.6
3.1
29.77
29.52
s
0.24
261
2064
187
1411
1.36
3.74
10.2
8.9
7.42
7.41
ph
0.43
102
734
187
1414
1.36
3.70
10.0
8.8
5.00
5.12
kpa
1.03
179
1367
177
1327
1.37
3.69
3.2
3.4
10.14
10.22
g/l
0.10
164
1247
967
8849
1.21
3.69
10.0
10.0
4.06
3.98
e9/l
0.44
833
7662
518
4461
1.23
3.69
4.6
3.1
0.00
0.03
estimate
0.93
140
1378
195
1488
1.35
3.64
4.9
4.3
32.52
32.30
%
0.10
127
1035
105
718
1.49
3.63
5.8
7.0
24.23
24.42
mmol/l
0.19
99
687
826
7455
1.20
3.63
7.7
7.3
2.78
2.84
%
0.33
778
7027
29
576
0.50
3.61
1.6
1.6
—
—
—
0
0
123
872
1.44
3.54
2.0
1.5
331.79
300.66
mu/l
0.63
112
778
183
1389
1.35
3.54
13.3
9.9
8.90
8.06
mmol/l
0.87
176
1345
29
569
0.50
3.49
1.6
1.5
—
—
—
0
0
145
1063
1.40
3.47
9.0
7.1
—
—
—
0
0
825
7466
1.20
3.46
7.9
7.4
8.52
8.62
%
0.48
775
7049
39
208
1.89
3.45
1.8
3.2
—
—
—
0
0
34
173
1.98
3.44
4.6
3.9
6.38
6.74
mmol/l
0.26
24
146
28
553
0.50
3.44
1.6
1.5
1.23
1.27
mm
0.16
21
409
523
4543
1.22
3.37
1.5
1.5
2.06
1.95
u/ml
0.07
128
1139
99
680
1.48
3.37
16.0
12.1
1.39
1.27
mg/l
0.91
90
638
347
2889
1.25
3.34
4.2
2.9
537.86
544.04
mosm/kgh2o
0.18
312
2561
318
2622
1.26
3.33
1.4
1.3
24.74
28.09
iu/ml
0.27
99
730
45
759
0.58
3.26
1.5
1.5
59.06
61.06
ug/l
0.14
38
660
130
957
1.39
3.06
1.7
1.7
22.50
18.93
iu/l
0.64
107
765
46
270
1.72
3.03
2.1
1.7
22.39
27.30
ng/l
0.45
46
270
516
4519
1.20
3.00
3.5
2.9
0.00
0.03
—
10
74
59
373
1.60
2.94
3.0
2.4
128.39
131.51
g/l
0.56
54
312
107
768
1.42
2.93
1.8
1.7
0.26
0.28
mg/l
0.16
44
352
123
908
1.38
2.87
2.3
2.4
6.39
7.27
ug/l
0.32
93
804
83
571
1.48
2.84
1.2
1.2
—
—
—
0
0
45
268
1.70
2.83
7.7
4.6
2.02
2.37
mmol/l
0.31
27
166
36
201
1.81
2.82
3.2
4.3
1.87
1.21
%
0.45
31
190
25
123
2.05
2.82
1.8
1.8
13.52
21.24
umol/l
1.56
25
115
55
346
1.61
2.81
2.3
2.5
10.82
11.58
mg/l
0.33
48
327
9
23
3.93
2.77
2.3
2.3
2.11
2.04
%
—
9
23
91
641
1.44
2.77
2.4
4.1
21.88
21.30
s
0.56
78
587
289
2411
1.24
2.72
1.3
1.3
8.40
9.68
u/ml
0.15
117
903
751
6838
1.17
2.72
3.1
2.9
—
—
estimate
—
0
0
37
211
1.77
2.72
1.6
1.7
285.79
283.87
mosm/kgh2o
0.28
28
157
258
2127
1.25
2.71
1.4
1.4
656.00
479.02
titre
0.56
50
408
142
1083
1.34
2.71
3.3
2.5
0.18
0.38
e6/l
1.41
134
1029
9
24
3.76
2.67
1.7
1.2
—
—
—
0
0
165
1289
1.31
2.66
5.7
4.8
0.80
0.91
%
0.28
62
384
7
15
4.68
2.59
1.6
1.1
—
—
—
0
0
204
1647
1.27
2.56
1.3
1.2
—
—
—
0
0
67
455
1.49
2.48
2.3
2.3
435.65
466.45
ug/l
0.05
62
432
157
1232
1.30
2.47
5.4
4.6
0.90
0.57
%
0.82
59
361
83
589
1.43
2.46
1.3
1.6
—
13.14
iu/ml
—
0
17
25
130
1.94
2.46
3.6
3.6
65.60
54.15
%
2.21
20
123
160
1266
1.29
2.37
1.5
1.4
394.10
295.15
u/ml
0.24
143
1167
8
22
3.65
2.36
3.1
2.7
20.55
26.88
umol/l
—
8
22
1312
12563
1.18
2.28
4.3
3.8
1.28
1.24
mmol/l
0.95
1208
11725
16
72
2.23
2.27
4.5
8.0
8.62
251.17
ug/l
0.55
11
48
372
3238
1.19
2.27
3.5
3.0
335.79
335.44
umol/l
0.02
336
2925
27
149
1.82
2.25
1.3
1.4
4.31
6.54
u/ml
0.28
15
86
529
4745
1.16
2.23
2.9
2.5
—
—
—
0
0
85
618
1.39
2.23
2.7
2.3
—
—
—
0
0
10
35
2.87
2.21
1.1
1.0
8.11
6.24
mg/g
—
10
35
155
1236
1.28
2.18
5.9
4.9
0.20
0.10
%
0.53
54
330
123
954
1.31
2.14
2.5
2.4
26.61
21.12
au/ml
—
9
96
10
36
2.79
2.13
1.1
1.0
—
—
—
0
0
31
182
1.72
2.12
1.5
1.4
280.32
384.96
pmol/l
0.78
25
158
71
505
1.42
2.12
1.4
1.2
—
—
—
0
0
15
68
2.22
2.11
1.8
2.1
71.93
122.71
ng/l
1.98
15
68
46
300
1.55
2.09
1.1
1.1
16.67
176.43
iu/ml
—
9
80
416
3680
1.17
2.08
4.0
3.6
0.00
0.07
—
6
30
118
915
1.31
2.06
3.3
3.4
164.87
192.94
ng/l
0.35
106
832
135
1068
1.29
2.03
1.4
1.5
—
—
—
0
0
18
90
2.01
2.00
8.2
3.0
499.69
140.11
umol/l
1.06
13
54
82
607
1.37
1.96
1.3
1.3
—
—
—
0
0
8
27
2.97
1.93
1.6
1.3
87.50
95.74
umol/l
—
8
27
281
2421
1.19
1.92
3.2
3.7
720.80
502.95
ng/l
0.24
181
1719
69
498
1.40
1.92
1.8
1.8
42.52
40.41
nmol/l
0.28
69
482
24
136
1.78
1.87
1.0
1.0
—
—
—
0
0
160
1308
1.25
1.86
1.3
1.2
139.61
145.30
u/ml
0.05
57
480
1398
13523
1.17
1.85
5.6
4.9
2.66
2.71
mmol/l
1.09
1303
12718
56
394
1.44
1.81
1.4
2.2
9.85
10.35
g/l
0.41
44
364
1386
13405
1.16
1.81
5.1
4.5
4.53
4.59
mmol/l
1.37
1294
12663
127
1015
1.27
1.79
1.2
1.2
—
—
—
0
0
49
337
1.47
1.78
1.5
1.6
0.31
0.35
nmol/l
0.27
38
273
153
1251
1.24
1.78
6.4
5.1
0.19
0.15
%
0.11
52
300
153
1251
1.24
1.78
2.5
2.2
11.56
11.71
nmol/l
0.08
144
1136
43
289
1.50
1.75
1.3
1.6
60.75
68.88
mmol/l
0.66
32
241
341
3011
1.16
1.74
5.3
5.1
1.88
2.74
ug/l
1.40
296
2732
106
833
1.29
1.72
13.4
11.0
95.39
94.40
%
2.31
106
828
1376
13317
1.15
1.71
5.1
4.4
1.44
1.45
mmol/l
0.84
1282
12503
14
68
2.07
1.70
1.1
1.4
154.77
142.62
nmol/l
0.40
14
68
97
757
1.30
1.66
2.0
2.5
—
—
—
0
0
7
25
2.81
1.65
1.4
1.2
—
—
—
0
0
44
629
0.69
1.64
1.1
1.1
1.54
1.52
g/l
0.13
44
629
73
548
1.35
1.64
1.4
1.2
0.47
1.12
u/ml
—
7
30
82
628
1.32
1.62
1.1
1.2
1.07
2.97
u/ml
2.48
49
383
51
362
1.42
1.60
2.1
2.1
0.86
0.80
nmol/l
0.34
44
310
26
159
1.64
1.59
1.0
1.2
—
—
u/ml
—
0
0
131
1068
1.24
1.59
2.0
1.9
1.28
1.28
g/l
0.01
118
1000
73
552
1.34
1.58
2.3
2.1
1.30
1.49
g/l
0.91
62
502
89
694
1.30
1.55
2.3
2.1
0.00
1.05
estimate
0.51
27
242
36
240
1.51
1.55
1.3
1.4
18.51
18.94
u/l
0.03
30
203
395
3556
1.14
1.55
5.4
4.8
—
—
—
0
0
65
485
1.35
1.54
2.8
1.8
3.85
1.92
ug/l
0.66
57
428
46
641
0.71
1.51
1.2
1.1
0.88
0.88
g/l
0.01
46
641
48
342
1.41
1.49
1.9
1.9
205.17
197.06
pmol/l
0.17
48
327
440
4005
1.13
1.45
1.6
1.6
2.21
2.11
g/l
0.36
270
2434
87
684
1.29
1.44
1.0
1.1
—
—
—
0
0
84
659
1.29
1.42
1.0
1.1
—
—
—
0
0
20
118
1.70
1.41
1.4
1.1
—
—
—
0
0
234
2042
1.17
1.41
2.2
1.9
—
—
—
0
0
43
595
0.72
1.37
1.1
1.1
0.58
0.64
ratio
—
5
57
73
567
1.30
1.34
1.1
1.1
4.58
7.10
u/ml
0.98
44
360
34
232
1.47
1.34
1.3
1.6
—
—
—
0
0
142
1192
1.21
1.34
3.1
2.4
5024.13
6128.20
u/l
0.21
58
439
59
773
0.75
1.33
1.3
1.7
—
—
—
0
0
71
552
1.30
1.30
1.1
1.1
0.60
1.53
u/ml
1.59
37
305
56
421
1.34
1.30
1.6
1.4
294.23
295.69
ug/g
0.02
35
234
183
1579
1.18
1.28
13.4
10.0
—
—
—
0
0
15
84
1.79
1.27
2.2
2.6
1.69
2.29
mmol/l
—
10
67
6
25
2.40
1.24
2.0
1.2
—
—
—
0
0
6
25
2.40
1.24
1.0
1.2
—
—
—
0
0
563
5243
1.11
1.23
2.1
2.0
—
—
—
0
0
120
1430
0.83
1.22
1.6
1.6
879.10
963.59
mu/l
0.66
110
1266
60
461
1.31
1.22
2.3
2.0
2.88
15.43
iu/l
0.56
29
202
273
2442
1.14
1.19
2.3
2.9
101.63
113.06
ug/g
0.36
207
1949
600
5616
1.10
1.18
2.0
1.9
1.31
1.34
mmol/l
0.30
502
4879
6
26
2.31
1.18
1.2
1.9
—
—
—
0
0
138
1171
1.19
1.18
2.7
2.4
6.11
6.20
ph
0.61
104
773
8
38
2.11
1.18
1.0
1.6
39.55
40.39
g/l
—
8
38
19
117
1.63
1.18
1.3
1.2
—
—
—
0
0
199
1743
1.16
1.17
1.6
1.5
—
—
—
0
0
76
607
1.26
1.16
1.7
1.8
4.97
7.27
iu/ml
0.60
11
136
18
110
1.64
1.15
1.9
1.2
—
—
—
0
0
102
843
1.22
1.15
1.3
1.2
—
—
—
0
0
8
39
2.06
1.15
5.1
6.5
5.10
4.92
kpa
—
8
39
5
20
2.50
1.15
1.8
1.5
—
—
—
0
0
51
387
1.33
1.14
2.5
4.1
1.41
1.35
mmol/l
0.14
51
380
11
58
1.90
1.12
1.9
1.5
—
—
—
0
0
8
40
2.00
1.12
1.3
2.6
—
—
—
0
0
23
151
1.53
1.11
1.7
2.1
33.17
32.56
pg
0.38
23
151
27
184
1.47
1.11
3.2
4.5
—
—
—
0
0
26
176
1.48
1.10
1.2
1.3
0.48
0.36
g/l
0.88
21
134
26
176
1.48
1.10
1.2
1.3
6.99
6.53
g/l
0.40
21
136
26
176
1.48
1.10
1.2
1.3
3.48
2.50
g/l
1.62
21
135
16
96
1.67
1.10
81.1
43.8
6.83
6.98
ug/l
0.12
16
84
12
66
1.82
1.09
1.2
1.2
150.15
208.47
iu/ml
0.71
12
66
21
137
1.54
1.05
1.6
1.8
—
—
—
0
0
20
129
1.56
1.05
1.5
1.2
118.25
116.22
pmol/l
0.07
20
129
24
162
1.49
1.04
2.1
1.9
1.07
0.87
%
0.47
15
99
23
154
1.50
1.03
1.4
1.2
—
—
—
0
0
21
138
1.53
1.03
2.5
2.5
-0.02
0.49
mmol/l
0.29
21
130
5
107
0.47
1.01
1.0
1.4
—
—
—
0
0
29
205
1.42
1.01
1.1
1.2
—
—
—
0
0
9
48
1.88
1.00
1.3
1.5
—
—
—
0
0
7
35
2.00
1.00
1.0
1.1
—
—
—
0
0
7
35
2.00
1.00
1.0
1.1
—
—
—
0
0
7
35
2.00
1.00
1.0
1.1
—
—
—
0
0
52
406
1.29
0.98
1.1
1.1
12.91
9.57
u/ml
0.16
30
219
14
84
1.67
0.98
1.6
1.8
1.05
1.18
nmol/l
—
7
65
7
37
1.90
0.94
3.0
1.9
—
—
—
0
0
81
671
1.22
0.93
5.4
3.2
1.02
1.02
ratio
1.14
74
608
10
172
0.58
0.93
1.2
1.4
—
—
—
0
0
12
70
1.72
0.92
1.9
3.0
9.26
7.91
mmol/l
0.53
12
70
14
86
1.63
0.91
1.5
1.2
180.79
184.25
pmol/l
0.03
14
86
353
3261
1.10
0.91
3.7
2.8
5.12
6.81
e6/l
2.52
325
2983
25
177
1.42
0.88
1.2
1.3
—
—
—
0
0
6
30
2.00
0.87
2.7
3.1
3.50
6.26
ug/l
—
6
30
8
45
1.78
0.84
1.4
1.5
49.75
91.04
nmol/24h
—
8
45
272
2492
1.11
0.83
2.3
2.8
2.45
2.44
mmol/l
0.55
235
2217
1342
13141
1.09
0.82
20.7
17.7
333.57
333.12
g/l
1.03
1332
13047
156
1747
0.88
0.78
1.8
1.8
3.52
3.42
ratio
0.46
119
1304
13
82
1.59
0.78
1.2
1.2
1.04
1.07
ratio
1.01
13
73
21
291
0.72
0.76
1.1
1.1
4.15
3.48
eliau/ml
—
6
119
18
124
1.46
0.75
2.9
3.2
24.61
26.48
umol/l
0.40
18
119
66
551
1.21
0.74
1.1
1.1
2.30
2.88
u/ml
0.29
39
342
46
370
1.25
0.73
2.6
3.6
61.44
64.13
mg/l
0.04
37
318
26
193
1.35
0.73
1.2
1.2
—
—
—
0
0
5
25
2.00
0.72
1.4
2.2
6.72
7.22
mmol/l
—
5
13
279
2580
1.10
0.72
4.0
3.0
0.96
1.09
e6/l
0.27
159
1339
180
1628
1.12
0.71
1.8
1.8
—
—
—
0
0
43
532
0.80
0.71
1.1
1.2
—
—
—
0
0
9
142
0.63
0.69
1.4
1.3
—
—
—
0
0
37
292
1.27
0.69
4.5
3.3
20.15
27.11
mg/l
1.07
30
197
14
93
1.51
0.69
1.2
1.7
10.83
3.76
u/ml
0.41
14
93
5
27
1.85
0.68
2.2
2.1
—
—
—
0
0
189
1721
1.11
0.67
3.1
3.8
8.11
7.65
umol/l
0.09
156
1480
5
94
0.53
0.66
1.4
1.2
—
—
—
0
0
1329
13048
1.08
0.66
21.0
17.5
13.44
13.42
%
0.25
1312
12874
505
4807
1.07
0.64
4.7
3.5
27.71
67.45
e6/l
1.75
403
3635
385
3629
1.08
0.64
2.8
2.4
—
—
—
0
0
23
172
1.34
0.63
2.4
3.5
221.81
195.84
e6/l
0.36
16
132
124
1107
1.13
0.63
3.3
4.3
2.76
18.50
ug/l
2.37
99
893
21
155
1.36
0.63
4.3
4.7
159.87
56.93
u/ml
—
7
50
52
433
1.21
0.63
1.1
1.1
14.83
5.62
u/ml
0.39
29
253
17
121
1.41
0.62
1.3
1.4
162471.00
185171.49
e6/l
—
9
80
166
1510
1.11
0.61
1.3
1.4
—
—
—
0
0
5
30
1.67
0.61
1.6
1.7
—
—
—
0
0
26
200
1.30
0.60
1.2
1.4
1.55
3.72
u/ml
0.74
15
109
46
382
1.21
0.58
3.1
2.6
—
—
—
0
0
101
896
1.13
0.58
1.6
1.5
—
—
—
0
0
8
55
1.46
0.56
2.5
2.3
16.57
16.97
umol/l
—
8
55
26
203
1.28
0.55
1.1
1.1
6.02
7.90
iu/ml
—
5
46
10
65
1.54
0.55
2.1
2.9
14.53
16.62
%
—
10
65
10
65
1.54
0.55
2.2
1.3
—
—
—
0
0
21
159
1.32
0.55
2.5
3.4
—
—
—
0
0
46
385
1.20
0.55
1.1
1.1
1.53
0.34
u/ml
0.37
17
152
8
122
0.65
0.54
1.5
1.5
—
—
—
0
0
66
572
1.16
0.53
3.2
2.4
—
—
—
0
0
34
277
1.23
0.52
1.8
1.7
0.87
0.73
g/l
0.20
27
224
44
369
1.20
0.52
2.7
3.6
32.36
43.34
mg/l
0.80
36
318
387
3681
1.07
0.51
4.9
4.8
90.03
89.95
%
0.02
378
3602
12
84
1.43
0.49
2.9
2.0
—
—
—
0
0
91
1016
0.89
0.49
1.6
1.5
—
—
—
0
0
16
119
1.35
0.48
1.1
1.1
—
—
—
0
0
34
281
1.21
0.47
1.1
1.1
—
—
—
0
0
11
154
0.71
0.47
1.5
2.1
—
—
—
0
0
57
495
1.16
0.46
1.7
1.6
0.22
0.23
g/l
0.13
52
470
32
264
1.22
0.46
2.1
1.8
—
—
—
0
0
32
264
1.22
0.46
2.1
1.8
—
—
—
0
0
32
264
1.22
0.46
2.1
1.8
—
—
—
0
0
32
264
1.22
0.46
2.1
1.8
—
—
—
0
0
76
853
0.89
0.45
1.9
1.9
—
—
—
0
0
7
50
1.40
0.45
1.3
1.2
—
—
—
0
0
258
2435
1.07
0.44
4.4
3.1
4.95
2.84
e6/l
1.20
143
1196
270
2851
0.94
0.43
1.8
2.0
—
—
—
0
0
437
4196
1.06
0.43
4.7
3.3
0.30
0.37
e6/l
0.43
338
3068
73
652
1.12
0.41
1.9
1.8
—
—
—
0
0
38
323
1.18
0.41
2.5
3.5
6.82
2.45
ratio
0.42
26
186
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
144
1335
1.09
0.40
2.2
2.0
0.00
0.02
estimate
1.05
31
310
239
2259
1.07
0.40
1.8
1.6
—
—
—
0
0
141
1520
0.92
0.40
1.2
1.3
—
—
—
0
0
148
1375
1.08
0.40
2.2
2.3
35.91
71.85
u/l
0.50
121
1136
26
214
1.22
0.39
3.4
3.4
0.77
0.82
nmol/l
0.28
17
174
7
104
0.67
0.39
1.6
1.7
—
—
—
0
0
491
4745
1.05
0.38
6.5
6.8
—
—
—
0
0
15
192
0.78
0.38
1.7
2.0
—
—
—
0
0
15
192
0.78
0.38
1.5
1.6
—
—
—
0
0
124
1339
0.92
0.38
1.4
1.6
3.40
3.38
mmol/l
0.05
84
901
36
419
0.86
0.37
1.5
1.1
—
—
—
0
0
43
374
1.15
0.37
6.9
9.3
—
—
—
0
0
41
471
0.87
0.36
1.4
1.3
—
—
—
0
0
36
417
0.86
0.36
1.5
1.1
—
—
—
0
0
12
90
1.34
0.35
3.3
2.1
—
—
—
0
0
168
1787
0.93
0.35
3.0
3.1
0.86
0.75
ug/l
0.40
104
1094
20
244
0.82
0.35
1.6
1.4
—
—
—
0
0
6
45
1.33
0.33
2.8
1.9
1.42
23.92
u/ml
—
6
35
12
91
1.32
0.33
1.6
3.6
614.75
1027.73
u/ml
1.13
12
91
12
155
0.77
0.33
1.1
1.3
—
196.79
—
0
28
12
155
0.77
0.33
1.1
1.3
—
296.00
—
0
5
140
1493
0.93
0.32
1.6
1.4
—
—
—
0
0
20
164
1.22
0.32
1.2
1.2
0.35
4.34
u/ml
1.06
13
72
10
74
1.35
0.32
1.5
1.3
—
—
—
0
0
153
1441
1.07
0.31
1.4
1.5
—
—
—
0
0
10
131
0.76
0.31
1.9
1.2
—
—
—
0
0
13
164
0.79
0.30
1.0
1.0
7.98
8.54
mu/l
0.21
13
143
39
440
0.88
0.29
2.4
1.7
151.27
129.06
au/ml
0.55
11
146
8
108
0.74
0.29
6.5
3.5
0.25
0.82
index
—
8
108
8
108
0.74
0.29
1.0
1.5
—
—
—
0
0
17
139
1.23
0.29
1.3
1.7
57.63
57.78
%
—
8
97
8
110
0.73
0.29
2.6
2.3
—
—
—
0
0
41
460
0.89
0.28
2.2
1.7
—
—
—
0
0
8
64
1.25
0.27
1.4
1.3
126.13
168.12
mmol/24h
—
8
64
23
196
1.18
0.27
1.7
1.3
2.42
15.60
u/ml
0.69
13
93
13
104
1.25
0.26
1.0
1.0
—
—
—
0
0
27
310
0.87
0.26
1.3
1.2
—
—
—
0
0
28
320
0.87
0.26
1.4
1.3
—
—
—
0
0
22
188
1.17
0.25
1.3
1.3
—
0.47
nmol/l
—
0
10
20
170
1.18
0.24
2.1
3.5
460.69
560.10
e6/l
0.54
13
126
11
137
0.80
0.24
1.0
1.0
3.31
3.09
kpa
0.21
11
117
5
39
1.28
0.23
1.0
1.1
—
—
—
0
0
73
783
0.93
0.22
1.3
1.3
242.39
242.92
miu/ml
0.00
31
392
23
200
1.15
0.22
2.4
3.4
1426.69
1393.50
e6/l
0.09
16
160
39
430
0.90
0.21
4.1
3.0
54.69
56.64
%
0.40
39
430
13
107
1.22
0.21
1.2
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
7.12
—
0
6
16
135
1.19
0.21
1.1
1.1
—
—
—
0
0
20
173
1.16
0.21
2.8
2.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
0.14
—
0
6
51
552
0.92
0.20
1.9
1.6
143.07
208.85
u/ml
2.83
27
292
27
240
1.13
0.20
1.4
1.3
2.82
4.35
u/ml
0.75
17
110
27
240
1.13
0.20
1.6
1.8
—
—
—
0
0
9
113
0.80
0.20
1.8
1.4
6.69
6.38
mmol/l
—
9
106
31
279
1.11
0.19
1.1
1.1
—
—
—
0
0
27
301
0.90
0.18
1.1
1.1
—
—
—
0
0
111
1058
1.05
0.18
2.5
1.9
—
—
—
0
0
26
233
1.12
0.17
1.1
1.1
—
—
—
0
0
41
444
0.92
0.17
3.0
3.4
1336.87
3376.33
u/ml
0.39
36
378
15
129
1.16
0.17
1.9
1.2
—
—
—
0
0
13
152
0.85
0.17
1.8
2.4
1.93
1.48
g/24h
—
7
95
20
225
0.89
0.16
1.6
1.2
—
—
—
0
0
8
71
1.13
0.16
1.0
1.1
19.59
39.90
iu/ml
—
8
71
18
159
1.13
0.15
1.3
1.3
0.18
0.30
nmol/l
0.48
13
122
128
1328
0.96
0.15
2.0
1.8
—
—
—
0
0
12
139
0.86
0.14
1.0
1.0
—
—
—
0
0
35
325
1.08
0.13
1.2
1.2
—
—
—
0
0
9
110
0.82
0.13
3.4
3.6
17.44
81.20
u/ml
—
9
110
27
248
1.09
0.12
1.1
1.1
—
—
—
0
0
15
169
0.89
0.12
1.1
1.2
—
—
—
0
0
28
258
1.09
0.12
2.0
2.5
180.96
121.48
ug/min
0.14
17
154
32
298
1.08
0.11
3.9
3.4
3.35
3.95
e9/l
1.32
32
298
16
143
1.12
0.11
1.1
1.1
—
—
—
0
0
42
396
1.06
0.11
2.0
3.2
9.73
8.57
umol/l
0.08
31
316
18
163
1.11
0.10
4.9
4.0
—
—
—
0
0
5
45
1.11
0.09
1.6
1.2
34.00
27.80
s
—
5
45
5
46
1.09
0.09
3.4
2.2
23.20
31.72
%
—
5
46
173
1693
1.02
0.09
1.3
1.3
—
—
—
0
0
5
47
1.06
0.09
2.2
1.1
—
—
—
0
0
5
47
1.06
0.09
2.2
1.1
—
—
—
0
0
5
47
1.06
0.09
2.2
1.1
—
—
—
0
0
13
145
0.90
0.09
1.5
1.6
0.44
0.49
e9/l
0.46
13
145
12
134
0.89
0.08
1.7
1.5
29.81
32.91
g/l
0.34
12
122
57
548
1.04
0.08
1.6
1.6
14.84
9.59
u/ml
0.26
16
122
7
64
1.09
0.08
1.3
1.4
—
—
—
0
0
6
72
0.83
0.07
8.0
3.3
—
—
—
0
0
96
935
1.03
0.07
3.4
2.5
—
—
—
0
0
6
75
0.80
0.07
1.2
1.3
3.42
7.65
u/ml
—
6
65
46
442
1.04
0.07
1.1
1.2
—
—
—
0
0
13
118
1.10
0.07
1.1
1.0
—
—
—
0
0
9
102
0.88
0.06
1.4
1.4
6.67
6.08
ug/l
—
9
91
494
4977
0.99
0.06
1.5
1.6
—
—
—
0
0
13
119
1.09
0.06
1.3
1.5
14.17
10.95
umol/l
0.74
13
109
125
1272
0.98
0.05
6.8
3.7
—
—
—
0
0
126
1241
1.02
0.04
2.4
1.9
—
—
—
0
0
548
5508
0.99
0.04
3.3
2.8
—
—
—
0
0
15
160
0.94
0.04
1.2
1.3
—
—
nmol/l
—
0
0
348
3457
1.01
0.04
1.9
1.8
—
—
—
0
0
132
1336
0.99
0.03
2.4
1.9
—
—
—
0
0
26
250
1.04
0.03
1.7
1.7
—
2253.33
—
0
6
14
132
1.06
0.02
2.4
3.9
0.28
0.33
e9/l
—
6
82
716
7178
1.00
0.02
13.6
11.3
0.00
0.00
e9/l
0.42
580
5808
41
401
1.02
0.02
1.1
1.1
25.41
15.96
au/ml
—
8
92
11
103
1.07
0.02
1.2
1.0
1658.91
1522.97
miu/ml
0.14
11
103
132
1330
0.99
0.01
2.4
1.8
—
—
—
0
0
31
317
0.98
0.01
1.4
1.4
60.65
227.44
pmol/l
2.22
31
307
570
5689
1.00
0.01
5.8
4.1
60.87
91.61
e6/l
0.92
423
3857
38
387
0.98
0.01
3.6
3.0
6.11
4.07
index
0.24
19
211
434
4349
1.00
0.01
2.1
2.2
—
—
—
0
0
132
1326
1.00
0.00
2.4
1.9
—
—
—
0
0
33
331
1.00
0.00
1.6
1.6
21922.43
12880.53
e6/l
0.31
23
241
15
149
1.01
0.00
1.0
1.1
—
—
—
0
0
15
148
1.01
0.00
5.4
3.3
17.00
14.48
index
—
8
108
15
150
1.00
0.00
1.3
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
0.16
—
0
9
5
51
0.98
-0.00
1.0
1.4
—
5.33
%
—
0
12
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.3
—
426.71
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
33.51
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
77.63
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
2.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1097.00
—
0
6
5
54
0.93
-0.00
5.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
29.61
—
0
7
0
5
0.00
-0.00
0.0
7.2
—
4.10
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
543.60
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
2.24
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
5.0
2.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
3166.67
—
0
6
8
80
1.00
-0.00
1.4
3.3
33.88
124.66
ug/l
—
8
70

Mortality – FinRegistry

Association

Association between endpoint H7_AMBLYANOPSIA and mortality.

Females

Parameter HR [95% CI] p-value
H7_AMBLYANOPSIA 1.145 [0.96, 1.36] 0.129
Birth year 0.993 [0.98, 1.0] 0.109

During the follow-up period (1.1.1998 — 31.12.2019), 491 out of 12381 females with H7_AMBLYANOPSIA died.

Males

Parameter HR [95% CI] p-value
H7_AMBLYANOPSIA 1.106 [0.9, 1.36] 0.347
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 12315 males with H7_AMBLYANOPSIA died.

Mortality risk

Mortality risk for people of age

years, who have H7_AMBLYANOPSIA.

N-year risk Females Males
1 0.091% 0.197%
5 0.531% 1.439%
10 1.477% 3.554%
15 3.156% 6.592%
20 5.152% 10.904%

Relationships between endpoints

Index endpoint: H7_AMBLYANOPSIA – Amblyopia ex anopsia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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