Benign neoplasm: Cranial nerves

CD2_BENIGN_CRANIAL_NERVE

cranial nerve malignant neoplasm: Benign and malignant neoplasms that arise from one or more of the twelve cranial nerves.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D33.3
  • Hospital discharge: ICD-9 2251
  • Hospital discharge: ICD-8 22403|2251
  • Cause of death: ICD-10 D33.3
  • Cause of death: ICD-9 2251
  • Cause of death: ICD-8 22403|2251

2 out of 7 registries used, show all original rules.

1170

4. Check minimum number of events

None

1170

5. Include endpoints

None

1170

6. Filter based on genotype QC (FinnGen only)

1075

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D33
Name in latin
Neoplasma benignum nervi cranialis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6100 3369 2687
Only index persons 5447 3043 2404
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.08
Only index persons 0.10 0.11 0.09
Median age at first event (years)
Whole population 56.38 56.92 55.69
Only index persons 55.98 56.46 55.36

-FinnGen-

Key figures

All Female Male
Number of individuals 1075 610 465
Unadjusted period prevalence (%) 0.22 0.22 0.21
Median age at first event (years) 57.34 56.37 58.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1103
Matched controls
11030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
17.3
313.3
286
219
DE2BG
NOMESCO Finland
Acoustic channel MRI examination with high intensity magnet
59.6
311.3
176
35
D33.30
ICD-10 Finland
Acoustic neuroma
+∞
307.7
926
*
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
96.9
307.7
333
49
9560/0-C72.4
ICD-O-3
Schwannoma, NOS, of acoustic nerve
+∞
307.7
344
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
56.4
307.7
218
48
DFF00
NOMESCO Finland
Pure tone audiometry
8.3
241.2
419
759
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
42.0
181.0
110
29
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.6
180.8
310
540
Z01.1
ICD-10 Finland
Examination of ears and hearing
5.5
148.9
391
1007
DFF15
NOMESCO Finland
Speech audiometry
7.5
125.0
201
320
DFF59
NOMESCO Finland
Other assessment of balance
19.2
118.5
95
54
9560/0-C72.5
ICD-O-3
Schwannoma, NOS, of cranial nerve, NOS
+∞
116.8
110
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.1
105.0
411
1396
G51.0
ICD-10 Finland
Bell palsy
10.5
101.9
118
125
D33.37
ICD-10 Finland
Another benign tumor of the cranial nerves
+∞
97.4
92
*
D33.39
ICD-10 Finland
Benign tumor of the cranial nerves UNS
+∞
96.3
91
*
D33.3
ICD-10 Finland
Benign neoplasm: Cranial nerves
+∞
95.2
90
*
2251A
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Cranial nerves
+∞
86.6
82
*
H02.2
ICD-10 Finland
Lagophthalmos
37.1
84.8
53
15
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
8.3
67.6
92
119
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
12.3
63.2
64
55
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
26.3
61.7
43
17
N07CA01
ATC
betahistine; oral
4.2
58.9
175
471
22510
ICD-8 Finland
Benign neoplasm of brain and other parts of nervous system, Cranial nerves (including optic)
+∞
55.7
53
*
AAE32
NOMESCO Finland
Translabyrinthine excision acoustic neurinome
+∞
52.5
50
*
UDC00
NOMESCO Finland
Ear microscopy
4.1
52.4
160
438
WF099
NOMESCO Finland
Other radiotherapy
19.3
52.0
41
22
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.1
49.9
91
161
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
16.8
49.7
42
26
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
130.8
47.2
50
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
12.6
45.5
45
37
AAE34
NOMESCO Finland
Other operations on acoustical nerv
+∞
45.1
43
*
H93.1
ICD-10 Finland
Tinnitus
3.8
44.7
152
447
Z3229
NOMESCO Finland
Other healthcare associate professional
3.6
43.9
162
503
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
3.8
42.7
142
411
ZXC40
NOMESCO Finland
Use of ultrasound
15.0
39.2
35
24
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.2
39.2
180
639
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
138.2
38.0
40
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
3.7
34.2
117
344
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
8.7
33.7
43
51
DE2DG
NOMESCO Finland
Acoustic channel very extensive MRI examination with high intensity magnet
74.2
32.0
36
5
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
+∞
31.4
30
*
WF002
NOMESCO Finland
Radical radiotherapy
3.5
30.2
109
331
DAX08
NOMESCO Finland
Fitting of hearing aid
3.2
28.2
119
399
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
27.5
235
1132
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.9
27.4
85
233
2152
FHL
Extraction, big brain
54.8
27.3
32
6
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
4.3
26.1
70
172
ZXH01
NOMESCO Finland
Procedure performed within operation theatre
74.5
25.9
29
*
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
266.6
25.8
26
*
D32.06
ICD-10 Finland
Benign tumor of the meninges os petrosum or clivus area
95.7
25.8
28
*
R42
ICD-10 Finland
Dizziness and giddiness
2.1
24.9
326
1854
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.4
23.6
47
90
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
8.4
23.6
31
38
R5120
NOMESCO Finland
Preparation of an aid
4.0
23.5
68
177
Z97.4
ICD-10 Finland
Presence of external hearing-aid
3.3
23.0
90
287
8000/0-C72.5
ICD-O-3
Neoplasm, benign of cranial nerve, NOS
+∞
23.0
22
*
AA1AD
NOMESCO Finland
CT of head and brain
1.9
22.2
393
2467
ZX050
NOMESCO Finland
Stereotactic radiotherapy
8.4
21.5
28
34
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
21.1
532
3720
DE2CM
NOMESCO Finland
Acoustic channel extensive MRI examination with 3 Tesla magnet
22.0
20.9
30
14
H02
ICPC
Hearing complaint
2.1
20.8
221
1152
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
78.3
20.7
23
*
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
5.5
20.1
39
73
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
19.8
321
1944
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
6.6
19.7
32
50
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
3.4
18.9
71
221
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
18.8
182
912
DC1AD
NOMESCO Finland
Temporalbone CT
7.3
18.3
27
38
9560/0-C72.9
ICD-O-3
Schwannoma, NOS, of nervous system, NOS
+∞
17.8
17
*
8000/0-C72.4
ICD-O-3
Neoplasm, benign of acoustic nerve
+∞
17.8
17
*
CBH25
NOMESCO Finland
Tarsorrhaphy
182.8
17.6
18
*
ZZC00
NOMESCO Finland
Graft of fascia
50.8
17.0
20
*
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
91.5
16.6
18
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
16.6
16.6
26
16
QAJ10
NOMESCO Finland
Browlift
28.0
16.5
22
8
XX3DW
NOMESCO Finland
Time consuming IT work
2.2
16.2
153
757
R4110
NOMESCO Finland
Physiotherapy
1.8
15.9
338
2200
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.4
15.8
40
94
CBH30
NOMESCO Finland
Tarsorraphy
+∞
15.7
15
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
15.5
432
3028
H91.9
ICD-10 Finland
Hearing loss, unspecified
2.7
14.8
84
330
DE2BM
NOMESCO Finland
Acoustic channel MRI examination with 3 Tesla magnet
81.2
14.6
16
*
DFF40
NOMESCO Finland
Otoneurologic examination of vertigo
12.8
14.4
25
20
H90.5
ICD-10 Finland
Sensorineural hearing loss, unspecified
5.0
14.3
31
64
H02.1
ICD-10 Finland
Ectropion of eyelid
5.9
14.0
25
43
G91.1
ICD-10 Finland
Obstructive hydrocephalus
13.8
13.8
23
17
Q85.09
ICD-10 Finland
Unspecified neurofibromatosis
76.1
13.6
15
*
Q85.1
ICD-10 Finland
Tuberous sclerosis
+∞
13.6
13
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
3.6
13.2
43
122
D32.0
ICD-10 Finland
Benign neoplasm: Cerebral meninges
15.3
13.1
21
14
SPAT1043
SPAT
Audiometry
2.1
13.0
136
699
3252
FHL
Repair with foreign material (spring, magnet)
+∞
12.5
12
*
D33.7
ICD-10 Finland
Benign neoplasm: Other specified parts of central nervous system
131.4
12.5
13
*
TAB00
NOMESCO Finland
Lumbar puncture
2.7
12.3
65
246
H81.3
ICD-10 Finland
Other peripheral vertigo
3.2
12.3
48
153
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
5.0
12.2
26
53
H02AB02
ATC
dexamethasone; systemic
2.0
11.9
148
808
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
4.4
11.5
29
68
D33.03
ICD-10 Finland
Pilosytic lateral astrocytoma of the strobe brain
+∞
11.5
11
*
D32.01
ICD-10 Finland
Benign tumor of meninges on interhemispheric surface
10.7
11.3
21
20
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
11.2
159
908
D33.2
ICD-10 Finland
Benign neoplasm: Brain, unspecified
43.8
10.9
13
*
D32.1
ICD-10 Finland
Benign neoplasm: Spinal meninges
43.8
10.9
13
*
Z3226
NOMESCO Finland
Physiotherapist
1.7
10.8
207
1291
G50.0
ICD-10 Finland
Trigeminal neuralgia
3.6
10.8
35
99
N03AF01
ATC
carbamazepine; oral, rectal
2.5
10.8
70
294
AAH50
NOMESCO Finland
Cranial nerve anastomosis
111.0
10.4
11
*
D33.0
ICD-10 Finland
Benign neoplasm: Brain, supratentorial
+∞
10.4
10
*
D32.04
ICD-10 Finland
Secondary or multiple benign tumor of the meninges above the exam
32.9
10.3
13
*
D33.45
ICD-10 Finland
Benign Schwannom in the nerve root of the spinal cord
32.9
10.3
13
*
R51.80
ICD-10 Finland
Headache
1.8
10.3
171
1022
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.0
10.2
122
657
H91.8
ICD-10 Finland
Other specified hearing loss
4.4
10.1
25
58
N75
ICPC
Benign neoplasm nervous system
40.4
10.0
12
*
9530/0-C70.9
ICD-O-3
Meningioma, NOS, of meninges, NOS
26.3
9.8
13
5
Q85.0
ICD-10 Finland
Neurofibromatosis (nonmalignant)
100.9
9.4
10
*
QAE40
NOMESCO Finland
Repair of anomaly or lesion after disease of skin of head or neck
17.7
9.4
14
8
ABB10
NOMESCO Finland
Resection of lesion of spinal canal
+∞
9.4
9
*
ZXA05
NOMESCO Finland
Left side
1.6
9.3
275
1913
R4135
NOMESCO Finland
Rehabilitation for hearing problems
3.3
9.1
33
101
D32.05
ICD-10 Finland
Cerebral meninges
15.7
9.0
14
9
N03AF02
ATC
oxcarbazepine; oral
2.8
8.9
43
156
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
50.4
8.7
10
*
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
9.1
8.5
17
19
WX402
NOMESCO Finland
General anaesthesia
1.6
8.5
240
1646
N76
ICPC
Neoplasm nervous system unspecified
27.7
8.5
11
*
ZZK00
NOMESCO Finland
Graft of nerve
90.7
8.4
9
*
H29
ICPC
Ear symptom/complaint other
1.8
8.4
143
860
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
4.9
8.4
18
37
H81.0
ICD-10 Finland
Ménière disease
3.1
8.4
35
117
D43.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Cranial nerves
+∞
8.3
8
*
CBK10
NOMESCO Finland
Operation for lagophtalmus
+∞
8.3
8
*
QAJ20
NOMESCO Finland
Subperiosteal facelift
+∞
8.3
8
*
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
8.3
321
2359
Z31.5
ICD-10 Finland
Genetic counselling
2.4
8.3
58
253
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
8.3
138
825
XCK00
NOMESCO Finland
Perimetry
2.1
8.3
74
358
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.0
8.2
35
118
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
8.1
86
443
CBJ50
NOMESCO Finland
Operation for ptosis of eyebrow
6.9
8.1
19
28
CBF99
NOMESCO Finland
Other operation for ectropion
17.3
8.1
12
7
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
22.2
8.0
11
5
CBF10
NOMESCO Finland
Shortening of canthal ligaments and tarsal plate for ectropion
22.2
8.0
11
5
H47.1
ICD-10 Finland
Papilloedema, unspecified
7.5
7.7
17
23
QAJ30
NOMESCO Finland
Other facelift
18.5
7.6
11
6
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
8.1
7.6
16
20
CBW99
NOMESCO Finland
Other operation on eyelid
25.2
7.6
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
7.3
374
2891
3259
FHL
Other measure in this category
+∞
7.3
7
*
H93.3
ICD-10 Finland
Disorders of acoustic nerve
+∞
7.3
7
*
H53.4
ICD-10 Finland
Visual field defects
3.1
7.2
30
100
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
7.1
750
6583
D36.1
ICD-10 Finland
Benign neoplasm: Peripheral nerves and autonomic nervous system
8.8
7.1
14
16
RK520, ,
NOMESCO Finland
10.1
7.0
13
13
G91.0
ICD-10 Finland
Communicating hydrocephalus
7.0
7.0
16
23
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
3.7
6.9
21
57
ZZF00
NOMESCO Finland
Graft of adipose tissue
5.5
6.9
19
35
R5140
NOMESCO Finland
Monitoring the use of the aid
1.7
6.9
130
804
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
40.3
6.8
8
*
DE2CF
NOMESCO Finland
Acoustic channel extensive MRI examination with median intensity magnet
40.3
6.8
8
*
2151
FHL
Resection, big brain
40.3
6.8
8
*
ZXC95
NOMESCO Finland
Use of surgical navigator
3.9
6.7
19
49
D32.07
ICD-10 Finland
Secondary or multiple benign tumor of the meninges below the exam
22.7
6.7
9
*
H53.1
ICD-10 Finland
Subjective visual disturbances
1.9
6.7
77
410
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
6.6
193
1330
G50.1
ICD-10 Finland
Atypical facial pain
3.1
6.5
26
85
RK320, ,
NOMESCO Finland
6.2
6.5
16
26
D33
ICD-10 Finland
Benign neoplasm of brain and other parts of central nervous system
70.2
6.4
7
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
6.3
211
1494
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
3.5
6.3
21
61
RL210, ,
NOMESCO Finland
11.1
6.3
11
10
G941, D3330,
ICD-10 Finland
+∞
6.3
6
*
C72.3
ICD-10 Finland
Malignant neoplasm: Optic nerve
+∞
6.3
6
*
C72.4
ICD-10 Finland
Malignant neoplasm: Acoustic nerve
+∞
6.3
6
*
D33.08
ICD-10 Finland
Another benign tumor of the cerebral ventricle
+∞
6.3
6
*
3253
FHL
Tarsoraphy
+∞
6.3
6
*
D33.15
ICD-10 Finland
Another benign tumor of the cerebellum
+∞
6.3
6
*
DQE20
NOMESCO Finland
Implantation of foreign material in vocal chord
+∞
6.3
6
*
TQA05
NOMESCO Finland
Puncture of skin of head or neck
26.8
6.2
8
*
D33.02
ICD-10 Finland
Another benign medial tumor of the cerebrum
26.8
6.2
8
*
CBN30
NOMESCO Finland
Shortening of canthal ligament
7.1
6.2
14
20
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
3.2
6.2
24
77
H16.0
ICD-10 Finland
Corneal ulcer
2.1
6.2
58
287
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
5.4
6.2
17
32
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
3.8
6.1
18
48
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
12.6
6.1
10
8
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
6.7
6.0
14
21
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.4
6.0
21
63
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
3.4
6.0
21
63

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
465
3328
1.69
15.45
2.2
2.4
—
—
—
0
0
383
2610
1.72
15.22
4.0
4.1
92.16
89.41
%
1.53
378
2556
122
618
2.10
12.08
1.3
1.3
38.26
58.58
au/ml
0.91
11
46
130
676
2.05
12.00
2.5
2.5
29.01
22.68
au/ml
0.34
14
54
126
652
2.05
11.78
8.6
9.9
24.17
24.33
mmol/l
0.24
126
643
600
4800
1.55
11.28
6.9
6.6
1.21
1.21
mmol/l
0.36
559
4435
355
2537
1.59
10.95
2.0
2.4
—
—
—
0
0
508
3988
1.51
9.98
2.3
2.2
—
—
—
0
0
59
244
2.50
9.43
1.7
1.2
95.90
53.09
e6/l
0.27
42
180
59
247
2.47
9.19
1.8
1.3
1951.55
602.91
e6/l
0.35
47
191
55
223
2.54
9.16
1.7
1.2
—
—
—
0
0
640
5323
1.48
9.12
7.8
7.2
1.21
1.21
mmol/l
0.32
563
4590
1040
9767
2.13
8.11
21.1
20.2
139.97
139.69
mmol/l
3.26
1025
9591
1041
9782
2.14
8.07
21.3
20.4
3.95
3.98
mmol/l
4.16
1026
9594
149
918
1.72
8.03
1.3
1.4
—
—
—
0
0
189
1242
1.63
7.97
7.6
8.0
0.60
0.95
mmol/l
0.54
143
1039
572
4731
1.43
7.90
2.6
2.8
—
—
estimate
—
0
0
704
6052
1.45
7.87
5.4
5.2
6.59
6.74
mmol/l
1.32
686
5768
189
1250
1.62
7.75
7.7
8.1
7.41
7.41
ph
0.57
102
702
188
1256
1.60
7.38
7.6
8.0
15.76
11.99
kpa
11.75
178
1217
188
1256
1.60
7.38
7.7
8.0
5.07
5.11
kpa
0.25
179
1217
1053
10065
2.02
5.72
23.5
22.5
77.10
77.83
umol/l
0.37
1046
9961
1002
9471
1.63
5.25
17.5
17.0
25.05
24.65
mg/l
0.13
856
7905
1045
9995
1.87
5.18
13.2
12.7
25.52
25.82
u/l
0.24
1020
9725
952
8928
1.48
4.83
5.7
5.5
1.86
1.95
mu/l
1.30
876
8222
28
116
2.45
4.58
2.0
1.2
—
—
—
0
0
536
4658
1.29
4.27
2.7
2.5
78.37
78.10
nmol/l
0.08
484
4175
617
5477
1.29
4.10
6.0
6.8
11.87
11.79
umol/l
0.04
590
5239
829
7712
1.30
3.50
8.5
8.5
78.13
79.77
u/l
0.44
783
7318
1056
10238
1.74
3.47
26.9
25.9
249.61
248.81
e9/l
0.15
1036
10050
1056
10239
1.74
3.45
27.0
25.8
90.85
91.36
fl
3.54
1049
10132
208
1629
1.34
3.44
2.1
2.0
28.97
29.37
s
0.49
203
1577
1056
10242
1.73
3.40
27.0
25.9
4.49
4.46
e12/l
1.54
1035
10021
1056
10244
1.72
3.37
27.1
26.1
134.77
134.47
g/l
0.30
1051
10134
101
702
1.48
3.32
10.6
9.8
0.62
0.64
%
0.22
101
696
553
4921
1.25
3.30
9.5
15.2
1.18
1.26
inr
3.05
456
4067
388
3321
1.26
3.25
2.4
2.2
182.90
222.97
u/l
0.68
374
3158
16
60
2.69
3.23
1.8
1.4
19.75
19.02
nmol/l
0.11
16
54
1055
10242
1.69
3.22
27.1
25.9
6.68
6.74
e9/l
0.49
1033
10019
1055
10242
1.69
3.22
27.0
25.8
30.23
30.38
pg
2.27
1048
10133
1055
10242
1.69
3.22
27.8
26.4
40.53
40.16
%
2.00
1048
10128
527
4675
1.24
3.20
4.7
5.0
35.97
35.46
g/l
1.30
492
4393
333
2809
1.27
3.14
2.9
3.2
0.14
0.03
—
7
66
410
3543
1.25
3.14
6.6
6.0
—
—
—
0
0
103
730
1.45
3.08
10.4
9.5
1.15
1.28
%
0.88
103
723
6
8
7.53
3.05
1.8
1.6
—
—
—
0
0
636
5788
1.23
2.95
9.1
9.9
4.12
4.13
e9/l
0.05
533
5045
102
728
1.44
2.95
10.5
9.6
95.10
93.80
%
0.86
102
722
390
3372
1.24
2.93
3.4
3.4
33.52
32.85
u/l
0.07
368
3199
537
4804
1.23
2.92
6.7
6.3
2.71
2.87
%
0.96
489
4497
536
4796
1.23
2.91
6.9
6.4
0.67
0.69
%
0.29
492
4480
536
4804
1.23
2.84
6.6
6.2
57.37
57.58
%
0.15
503
4582
544
4887
1.22
2.80
6.7
6.4
27.91
27.24
%
0.74
507
4631
535
4807
1.22
2.73
6.8
6.4
8.99
8.92
%
0.22
489
4501
232
1910
1.27
2.63
3.7
3.3
0.72
0.76
ug/l
0.32
157
1241
46
283
1.65
2.61
3.3
3.1
1.90
2.02
index
0.05
21
156
26
137
1.92
2.47
1.4
1.4
231.10
332.12
pmol/l
1.60
20
120
572
5206
1.21
2.46
6.5
6.2
0.04
0.04
e9/l
0.46
473
4453
586
5351
1.20
2.42
6.8
6.5
0.18
0.19
e9/l
0.61
490
4671
579
5283
1.20
2.40
6.6
6.3
1.84
1.91
e9/l
0.67
489
4639
569
5193
1.20
2.33
6.5
6.2
0.59
0.59
e9/l
0.01
469
4438
19
92
2.08
2.28
2.3
3.1
9.86
12.10
index
—
7
59
801
7557
1.22
2.26
4.5
4.4
14.83
14.85
pmol/l
0.09
728
6916
696
6483
1.20
2.23
3.5
3.4
45.52
50.92
u/l
1.04
655
6086
979
9452
1.32
2.22
5.4
5.3
4.64
4.62
mmol/l
0.41
903
8787
5
9
5.57
2.21
2.6
2.7
58.36
89.41
pmol/l
—
5
9
352
3085
1.21
2.21
5.6
6.3
—
—
—
0
0
974
9404
1.31
2.16
5.3
5.2
1.49
1.47
mmol/l
0.37
890
8680
252
2145
1.23
2.11
2.9
3.0
2.47
2.45
mmol/l
0.80
220
1922
585
5381
1.19
2.11
3.9
4.1
0.00
0.30
estimate
0.54
112
1068
963
9291
1.29
2.09
5.5
5.4
5.86
5.98
mmol/l
2.43
871
8507
574
5276
1.18
2.07
3.9
4.1
0.01
0.00
estimate
0.50
110
1115
1002
9722
1.33
2.06
15.2
15.3
—
—
—
0
0
125
984
1.30
2.02
2.7
2.6
32.54
41.38
u/l
0.80
109
825
37
232
1.62
2.01
1.7
1.3
12.70
10.23
u/l
0.31
24
188
65
462
1.43
1.99
1.2
1.2
—
—
—
0
0
990
9602
1.30
1.93
6.2
6.1
2.72
2.68
mmol/l
0.79
910
8889
54
377
1.45
1.84
2.2
1.8
21.08
21.04
s
0.02
48
343
151
1235
1.26
1.82
1.5
1.3
—
—
—
0
0
5
12
4.18
1.82
1.0
1.0
—
—
—
0
0
5
12
4.18
1.82
1.0
1.0
—
—
—
0
0
824
7856
1.19
1.80
21.8
21.0
13.63
13.70
%
0.84
815
7758
576
5336
1.17
1.79
3.9
4.1
13.72
4.60
estimate
0.29
116
1141
124
999
1.27
1.71
4.9
4.3
7.39
7.36
ph
3.05
83
717
319
2832
1.18
1.68
3.4
3.5
0.00
0.04
estimate
0.69
89
889
360
3231
1.17
1.65
4.7
4.1
7.40
7.40
ph
0.23
265
2349
122
987
1.27
1.63
4.8
6.8
9.01
9.78
mmol/l
0.64
115
950
12
56
2.16
1.61
1.6
1.3
157.17
170.36
pmol/l
0.16
12
56
355
3194
1.16
1.57
6.6
5.6
5.58
2.62
ug/l
0.63
324
2876
174
1473
1.22
1.55
4.9
5.5
1.01
1.03
mmol/l
0.56
159
1361
197
1688
1.20
1.55
3.3
3.2
2.41
2.27
e6/l
0.10
93
826
213
1843
1.19
1.51
3.1
3.2
0.83
0.82
mmol/l
0.60
198
1739
692
6547
1.15
1.50
5.2
4.9
99.64
1908.93
e6/l
2.44
11
99
212
1835
1.19
1.49
3.2
3.0
1.27
1.16
e6/l
0.15
104
983
6
22
2.74
1.43
1.2
1.1
—
—
—
0
0
507
4712
1.14
1.39
2.3
2.2
96.80
95.99
pmol/l
0.14
281
2472
9
42
2.15
1.34
3.8
3.5
27.67
32.60
umol/l
—
9
29
0
40
0.00
1.33
0.0
1.6
—
5333.33
—
0
6
461
4270
1.14
1.31
3.5
3.6
6.23
6.23
ph
0.00
231
2406
8
34
2.36
1.29
1.4
1.4
—
—
—
0
0
176
1521
1.19
1.27
1.2
1.2
—
—
—
0
0
480
4468
1.13
1.25
12.1
11.8
0.00
0.00
e9/l
0.16
379
3660
142
1207
1.20
1.24
1.9
1.7
—
—
—
0
0
151
1299
1.19
1.16
1.5
1.4
—
—
—
0
0
0
33
0.00
1.16
0.0
1.1
—
317.10
—
0
20
5
20
2.51
1.15
1.6
1.6
—
—
—
0
0
398
3678
1.13
1.15
3.4
3.5
2.36
2.36
mmol/l
0.38
349
3323
353
3238
1.13
1.15
3.1
3.3
—
—
—
0
0
0
36
0.00
1.14
0.0
1.3
—
41.55
—
0
17
35
250
1.41
1.14
2.0
2.2
130.44
128.45
g/l
0.16
25
200
14
233
0.60
1.12
3.7
3.6
0.70
0.83
nmol/l
—
8
193
140
1201
1.19
1.12
2.5
2.8
6.74
8.35
umol/l
1.07
126
1063
361
3321
1.13
1.12
2.6
2.6
63.07
86.76
u/l
0.47
333
3090
97
803
1.23
1.11
2.6
2.4
12.47
13.39
nmol/l
0.52
83
724
926
9020
1.17
1.10
4.5
4.4
1.26
1.29
mmol/l
0.57
830
8247
226
2021
1.15
1.07
3.3
3.0
544.25
528.77
mosm/kgh2o
0.46
197
1780
341
3136
1.13
1.05
1.7
1.7
21.27
20.31
nmol/l
0.54
275
2631
5
107
0.46
1.01
1.2
1.2
1.41
1.41
nmol/l
—
5
95
492
4636
1.11
0.98
3.1
3.0
124.38
134.33
ug/l
0.29
453
4310
0
30
0.00
0.97
0.0
1.3
—
97.92
—
0
22
28
200
1.41
0.94
2.0
2.1
5.41
4.79
mmol/24h
0.44
21
178
35
260
1.36
0.94
1.9
1.5
277.76
280.27
mu/l
0.03
35
235
24
167
1.45
0.92
2.5
1.6
—
—
—
0
0
448
4211
1.11
0.92
1.9
2.0
1.31
1.35
mmol/l
0.45
375
3512
19
126
1.52
0.91
1.9
1.3
—
—
nmol/l
—
0
0
225
2039
1.13
0.89
4.0
4.0
273.14
361.33
ng/l
0.30
185
1624
49
387
1.28
0.88
1.9
1.2
—
—
—
0
0
33
436
0.75
0.87
2.8
1.6
0.43
0.33
mg/l
0.46
16
192
44
344
1.29
0.85
4.2
3.6
18.19
3.26
ratio
0.61
28
200
6
31
1.94
0.84
1.5
1.3
24.83
27.13
s
—
6
31
929
9093
1.14
0.83
6.7
6.8
38.87
39.59
mmol/mol
1.75
851
8505
116
1009
1.17
0.82
1.9
2.1
0.00
0.03
estimate
0.78
30
197
38
293
1.31
0.82
1.1
1.1
—
—
—
0
0
28
206
1.37
0.82
3.5
2.9
6.57
8.59
pmol/l
0.97
28
206
408
3839
1.10
0.81
4.4
4.1
134.79
122.22
e6/l
0.05
286
2731
81
685
1.20
0.80
1.3
1.3
—
—
—
0
0
63
520
1.22
0.79
2.5
2.4
—
—
—
0
0
6
33
1.82
0.79
1.2
1.1
—
—
—
0
0
315
2931
1.10
0.78
3.7
3.3
0.35
0.43
e6/l
0.23
229
2163
294
2727
1.11
0.77
1.4
1.4
—
—
—
0
0
77
651
1.20
0.77
1.8
1.8
3.21
3.49
mmol/l
1.25
51
479
170
1529
1.13
0.77
2.0
2.0
—
—
—
0
0
25
336
0.74
0.76
1.1
1.1
—
—
—
0
0
9
53
1.70
0.75
3.7
2.5
—
—
—
0
0
198
1801
1.12
0.75
2.1
2.5
12.90
12.81
umol/l
0.04
178
1675
361
3392
1.10
0.73
3.7
3.5
54.73
86.35
e6/l
0.61
273
2610
5
25
2.00
0.72
1.0
2.1
—
—
—
0
0
9
56
1.61
0.72
1.2
1.3
9.52
5.79
ug/l
—
9
49
79
919
0.85
0.71
4.7
4.7
0.09
0.12
%
0.11
22
238
173
1567
1.12
0.71
2.2
2.5
22.28
22.46
%
0.05
155
1462
70
593
1.19
0.70
2.9
3.5
4.50
4.50
pmol/l
0.01
65
517
5
27
1.86
0.68
1.2
1.1
—
666.67
—
0
6
293
2739
1.09
0.66
2.4
2.2
2.91
2.92
mg/l
0.02
246
2355
140
1259
1.13
0.65
2.6
2.4
166.37
128.15
ug/g
0.55
110
1008
115
1021
1.14
0.65
2.6
2.1
368.97
382.29
nmol/l
0.27
101
956
61
515
1.20
0.64
2.0
2.1
0.00
1.62
estimate
0.50
22
155
33
261
1.27
0.63
1.3
1.5
—
—
—
0
0
33
261
1.27
0.63
1.3
1.5
—
—
—
0
0
84
961
0.86
0.62
4.4
4.4
0.79
0.98
%
0.48
28
308
12
79
1.52
0.62
1.1
1.2
—
—
—
0
0
17
121
1.41
0.62
1.7
1.9
—
—
—
0
0
33
262
1.27
0.61
1.3
1.5
—
—
—
0
0
184
1688
1.11
0.61
2.2
2.5
2.32
2.31
g/l
0.10
163
1563
15
105
1.43
0.60
1.5
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
2.1
—
16.81
—
0
21
80
914
0.87
0.59
4.4
4.3
0.50
0.63
%
0.41
30
287
60
511
1.18
0.59
3.5
3.6
1.02
1.02
ratio
1.28
50
481
45
373
1.22
0.58
4.5
3.9
53.42
65.03
mg/l
0.25
40
322
45
373
1.22
0.58
4.6
3.9
44.91
57.42
mg/l
0.30
40
324
33
264
1.26
0.58
1.3
1.5
—
—
—
0
0
424
4046
1.08
0.58
3.7
4.0
34.46
63.20
ng/l
0.75
312
3000
8
53
1.51
0.58
1.0
1.2
—
—
—
0
0
38
310
1.23
0.57
5.4
6.7
1.33
1.27
mmol/l
0.09
31
276
11
73
1.51
0.56
1.1
1.2
—
—
—
0
0
33
406
0.81
0.56
1.2
1.2
0.24
1.37
u/ml
—
7
23
30
239
1.26
0.55
1.4
1.5
—
—
—
0
0
10
65
1.54
0.55
1.1
1.7
13.90
13.23
umol/l
—
10
60
97
1086
0.88
0.55
3.8
3.5
2.02
1.82
mmol/l
0.19
88
941
42
502
0.83
0.54
3.3
3.4
25.45
25.34
mmol/l
0.08
42
488
211
2264
0.92
0.54
1.7
1.6
1.43
1.29
mg/l
0.15
156
1755
17
125
1.37
0.54
1.5
1.6
0.20
0.33
nmol/l
1.16
12
96
17
125
1.37
0.54
1.4
1.2
—
—
—
0
0
167
1809
0.91
0.52
1.4
1.3
26.42
13.24
u/ml
0.27
66
679
16
117
1.37
0.52
1.3
1.6
22.81
34.70
ng/l
0.57
16
117
6
40
1.50
0.51
2.3
3.2
—
—
—
0
0
13
180
0.72
0.51
1.1
1.1
—
—
—
0
0
6
41
1.47
0.50
1.3
1.1
—
—
—
0
0
14
101
1.39
0.49
1.4
1.4
11540.38
102568.11
e6/l
—
8
54
7
45
1.56
0.49
3.4
3.0
—
—
—
0
0
14
102
1.38
0.47
5.4
1.8
10.94
10.84
%
0.03
14
102
150
1384
1.10
0.47
1.3
1.3
—
—
—
0
0
82
915
0.89
0.46
4.4
4.5
0.08
0.11
%
0.28
26
262
40
338
1.19
0.46
1.3
1.5
285.19
285.97
ug/g
0.01
21
204
16
209
0.76
0.45
3.5
3.5
13.11
28.72
mg/l
—
8
143
14
103
1.36
0.45
2.8
2.3
—
—
—
0
0
24
192
1.26
0.45
1.6
2.2
3539.06
2691.73
u/l
—
9
78
284
2697
1.07
0.44
2.5
2.8
346.01
343.35
umol/l
0.15
244
2368
15
112
1.34
0.44
2.7
3.6
—
—
—
0
0
7
51
1.37
0.44
1.3
2.0
0.96
5.01
nmol/l
—
7
42
7
51
1.37
0.44
1.4
1.5
—
—
—
0
0
10
140
0.71
0.43
1.3
1.5
—
—
—
0
0
10
140
0.71
0.43
1.3
1.5
—
—
—
0
0
10
140
0.71
0.43
1.3
1.6
—
—
—
0
0
10
140
0.71
0.43
1.3
1.5
—
—
—
0
0
80
718
1.12
0.43
3.7
3.8
7.41
7.42
ph
0.34
66
608
28
230
1.22
0.42
4.1
3.8
—
—
—
0
0
13
173
0.75
0.42
1.1
1.0
—
—
—
0
0
212
2248
0.93
0.42
4.9
4.9
—
—
—
0
0
5
33
1.52
0.41
2.4
1.5
47.20
33.97
%
—
5
33
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
4.43
—
0
15
8
59
1.36
0.41
2.3
2.2
2.49
2.23
ug/l
—
8
50
31
259
1.20
0.41
1.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
4.48
—
0
12
412
3973
1.06
0.40
3.9
4.1
0.03
0.03
estimate
0.09
89
930
42
362
1.17
0.40
1.5
1.6
9.57
14.24
u/ml
—
6
71
7
101
0.69
0.39
1.1
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
2.4
—
3.00
—
0
19
0
19
0.00
0.39
0.0
1.1
—
0.63
—
0
14
36
419
0.85
0.38
1.9
1.8
—
—
—
0
0
9
67
1.35
0.38
2.6
1.5
78.78
80.85
umol/l
—
9
67
49
430
1.15
0.37
2.2
2.6
—
—
—
0
0
13
98
1.33
0.37
1.5
1.4
—
—
—
0
0
8
113
0.71
0.37
1.3
1.4
4.07
6.58
mmol/l
—
8
106
92
841
1.10
0.37
3.5
3.0
10.49
10.95
g/l
0.35
84
774
12
157
0.76
0.36
3.1
2.4
—
—
—
0
0
30
254
1.19
0.35
4.8
4.6
—
—
—
0
0
18
144
1.25
0.35
1.3
1.2
1.60
5.19
u/ml
—
10
59
16
126
1.27
0.35
1.8
1.3
—
—
—
0
0
33
283
1.17
0.34
2.8
3.2
8.25
8.12
kpa
0.17
33
278
182
1924
0.94
0.34
1.4
1.3
52.48
32.50
iu/ml
0.79
54
605
138
1292
1.08
0.33
3.1
3.3
4.12
5.19
e9/l
1.24
113
1112
87
799
1.10
0.33
2.5
2.7
5.95
6.09
ph
0.77
51
549
56
502
1.12
0.33
2.5
2.0
—
—
—
0
0
19
156
1.22
0.31
1.1
1.1
—
—
—
0
0
225
2353
0.95
0.31
3.9
4.3
1.02
1.02
kg/l
0.75
148
1588
83
899
0.92
0.30
2.7
2.4
6.26
7.34
ug/l
0.49
72
805
19
157
1.21
0.29
1.1
1.1
—
—
—
0
0
131
1233
1.07
0.29
2.4
2.6
1.79
1.83
%
0.20
117
1104
56
508
1.11
0.28
3.8
4.0
—
—
—
0
0
105
1122
0.93
0.28
3.7
3.5
7.39
7.38
ph
0.30
53
637
28
242
1.16
0.28
1.3
1.3
97.55
240.02
miu/ml
—
10
113
45
403
1.12
0.28
3.7
4.2
24.45
24.93
mmol/l
0.88
40
379
32
280
1.15
0.27
1.5
1.7
10673.04
12995.68
e6/l
0.16
23
195
152
1441
1.06
0.27
1.3
1.3
660.65
477.10
titre
0.48
31
317
189
1804
1.06
0.27
1.7
1.7
1087.38
1184.59
nmol/l
0.83
143
1354
15
122
1.23
0.27
3.6
2.6
—
—
—
0
0
59
645
0.91
0.26
1.2
1.2
121.33
147.04
u/ml
0.19
23
263
22
187
1.18
0.26
1.5
1.4
—
—
—
0
0
13
104
1.25
0.26
1.0
1.2
—
—
—
0
0
59
644
0.91
0.26
4.1
3.3
24.91
24.27
mmol/l
0.74
59
637
17
141
1.21
0.26
1.2
1.2
—
—
—
0
0
5
73
0.68
0.26
1.2
2.8
9.58
8.58
mmol/l
—
5
73
13
105
1.24
0.25
2.9
2.5
—
—
—
0
0
9
76
1.19
0.24
1.8
1.9
31.09
38.57
%
—
9
76
22
254
0.86
0.23
2.8
2.4
83.62
102.67
ug/min
0.18
13
153
5
38
1.32
0.23
1.2
1.1
—
—
—
0
0
65
701
0.92
0.23
4.1
3.0
133.85
128.46
g/l
1.44
65
684
5
40
1.25
0.22
1.0
1.3
9.40
9.73
mm/h
—
5
40
375
3659
1.04
0.22
3.2
3.4
7.68
7.41
mmol/l
0.57
313
3085
109
1032
1.06
0.22
2.3
2.3
0.22
0.21
g/l
1.01
102
969
0
11
0.00
0.21
0.0
2.1
—
0.51
—
0
11
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
33
296
1.12
0.21
6.4
10.1
—
—
—
0
0
16
188
0.85
0.21
1.5
1.3
201.60
274.49
u/ml
—
10
103
25
220
1.14
0.21
2.3
2.4
15.52
16.13
%
0.44
25
215
8
104
0.77
0.21
1.5
2.3
—
—
—
0
0
8
104
0.77
0.21
1.0
1.1
—
—
—
0
0
31
278
1.12
0.20
3.8
3.0
1.54
1.60
mmol/l
0.19
31
272
112
1065
1.06
0.20
1.7
1.6
—
—
—
0
0
224
2313
0.96
0.20
1.3
1.3
0.97
1.54
u/ml
0.90
49
611
9
113
0.79
0.20
1.8
2.3
—
—
—
0
0
6
50
1.20
0.19
1.0
1.1
1272.33
1727.66
miu/ml
—
6
50
6
51
1.18
0.19
1.0
1.2
1.05
1.07
ratio
—
6
45
26
232
1.12
0.18
2.7
2.8
89.82
89.68
%
0.04
26
225
12
100
1.20
0.18
1.6
1.4
1.28
1.30
mm
—
7
71
7
59
1.19
0.18
1.9
3.1
0.71
0.95
index
—
7
59
14
119
1.18
0.17
1.4
1.4
6188.22
1763.11
e6/l
—
9
79
17
195
0.87
0.17
1.2
1.2
—
—
—
0
0
120
1149
1.05
0.17
4.2
4.4
12.96
21.67
ug/l
0.38
99
957
101
1059
0.95
0.17
1.7
1.6
—
—
—
0
0
43
397
1.09
0.17
3.0
2.4
9.12
10.81
g/l
1.63
33
353
11
131
0.84
0.17
1.5
1.2
—
—
—
0
0
77
813
0.94
0.17
2.9
3.0
238.84
193.26
ng/l
0.15
70
749
5
69
0.72
0.17
1.4
1.8
—
—
—
0
0
50
466
1.08
0.16
1.1
1.1
—
—
—
0
0
12
101
1.19
0.16
1.6
1.4
—
—
—
0
0
6
77
0.78
0.15
1.0
1.0
—
—
—
0
0
290
2963
0.97
0.15
4.3
4.2
0.00
0.00
estimate
0.78
109
1047
77
809
0.95
0.15
1.2
1.2
—
—
—
0
0
52
488
1.07
0.15
1.5
1.8
1.63
1.54
g/l
0.24
42
432
42
391
1.08
0.15
1.8
2.0
128.43
441.80
ug/l
1.66
42
372
15
131
1.15
0.14
1.1
1.1
2.73
2.43
eliau/ml
—
6
52
14
160
0.87
0.14
2.8
2.5
—
—
—
0
0
19
212
0.89
0.14
1.2
1.1
—
—
—
0
0
12
103
1.17
0.13
1.6
1.6
—
—
—
0
0
62
653
0.95
0.13
1.9
1.7
—
—
—
0
0
22
199
1.11
0.13
1.3
1.6
—
—
—
0
0
13
148
0.88
0.12
1.2
1.0
6.09
3.54
u/ml
—
8
80
326
3314
0.98
0.12
2.9
3.2
1229.87
1260.10
ng/l
0.04
284
2847
86
827
1.04
0.12
1.3
1.4
—
—
—
0
0
20
182
1.10
0.11
1.8
1.9
—
—
—
0
0
12
105
1.14
0.11
1.0
1.1
—
—
—
0
0
27
250
1.08
0.11
1.6
1.3
—
—
—
0
0
74
770
0.96
0.11
3.4
2.6
—
—
—
0
0
22
239
0.92
0.10
5.4
3.2
59.82
58.01
%
0.21
22
239
41
433
0.94
0.10
1.6
1.9
5.72
7.51
iu/ml
—
6
105
145
1486
0.97
0.10
2.0
1.8
—
—
—
0
0
12
135
0.89
0.10
1.2
1.1
—
—
—
0
0
77
743
1.04
0.09
1.5
1.4
—
—
—
0
0
96
989
0.97
0.09
1.8
1.5
—
—
—
0
0
18
196
0.92
0.09
1.3
1.3
—
—
—
0
0
99
962
1.03
0.09
3.0
2.7
71.93
70.25
e9/l
0.18
73
706
27
288
0.94
0.09
1.1
1.2
0.85
0.92
g/l
1.04
27
288
6
58
1.03
0.08
1.0
1.3
127.33
149.05
nmol/l
—
6
58
31
293
1.06
0.08
4.6
4.0
3.85
3.89
mmol/l
0.17
31
288
240
2368
1.02
0.07
2.9
2.7
5.00
5.51
e6/l
0.29
216
2173
28
265
1.06
0.07
1.5
1.9
3.75
4.61
iu/l
0.25
13
102
8
90
0.89
0.06
1.1
1.1
—
—
—
0
0
35
366
0.95
0.06
4.3
3.9
1.56
1.41
mmol/l
0.18
35
358
34
325
1.05
0.06
5.4
3.4
1.55
1.55
mg/l
0.01
28
287
10
111
0.90
0.06
1.5
1.7
—
—
—
0
0
94
920
1.02
0.06
3.6
3.0
64.95
66.84
g/l
1.45
78
847
37
385
0.96
0.05
2.6
3.6
314.47
316.31
mg/l
0.01
15
161
11
100
1.10
0.05
1.1
1.2
—
—
—
0
0
299
2964
1.01
0.05
4.1
4.4
—
—
—
0
0
48
466
1.03
0.04
1.9
2.0
2.00
2.08
ug/l
0.03
39
419
12
130
0.92
0.04
1.1
1.2
—
—
—
0
0
360
3575
1.01
0.04
4.0
4.1
14.15
8.25
mg/mmol
0.31
206
2230
78
795
0.98
0.04
4.7
4.1
—
—
—
0
0
11
101
1.09
0.04
1.0
1.2
—
—
—
0
0
131
1293
1.01
0.04
1.6
1.6
—
—
—
0
0
50
513
0.97
0.04
1.3
1.3
—
—
—
0
0
26
271
0.96
0.04
1.3
1.3
—
—
—
0
0
12
129
0.93
0.03
2.8
2.2
0.45
1.11
g/24h
—
7
78
29
280
1.04
0.03
1.1
1.1
—
—
—
0
0
68
668
1.02
0.03
3.6
1.8
1.82
1.38
g/l
0.43
60
615
73
718
1.02
0.03
1.3
1.4
—
—
—
0
0
11
102
1.08
0.03
1.1
1.3
—
—
—
0
0
10
108
0.93
0.03
1.3
1.3
—
—
—
0
0
352
3508
1.01
0.01
3.3
3.5
33.45
42.93
mg/l
0.63
200
2250
221
2221
0.99
0.01
1.7
1.7
69886792.76
24986884.04
pmol/l
0.43
176
1845
17
177
0.96
0.01
1.5
1.6
—
—
—
0
0
362
3631
1.00
0.01
3.3
3.3
—
—
—
0
0
24
233
1.03
0.01
4.3
3.1
7.78
7.62
mmol/l
0.09
24
228
14
146
0.96
0.00
3.1
2.1
34.00
32.42
pg
0.81
14
146
88
874
1.01
0.00
4.4
3.6
93.95
86.66
ng/l
0.26
74
764
11
114
0.96
0.00
1.4
1.8
—
—
—
0
0
12
116
1.03
0.00
1.2
1.1
1.12
3.03
u/ml
—
6
48
15
146
1.03
0.00
1.3
1.5
34.14
32.68
g/l
0.23
15
136
18
184
0.98
0.00
5.9
3.4
4.78
4.30
e9/l
0.15
18
184
25
254
0.98
0.00
1.6
1.6
—
—
—
0
0
12
122
0.98
0.00
1.3
1.1
—
—
—
0
0
14
142
0.99
0.00
1.1
1.1
0.79
0.92
u/ml
—
6
62
17
172
0.99
0.00
1.4
1.3
136.00
162.51
au/ml
—
6
50
14
141
0.99
0.00
2.2
1.8
—
—
—
0
0
22
221
1.00
0.00
1.4
1.3
73.65
58.68
mmol/l
0.64
17
183
27
271
1.00
0.00
1.1
1.2
1.54
1.54
g/l
0.06
27
271
52
519
1.00
0.00
4.2
4.5
36.83
36.91
°c
0.85
52
514
10
97
1.03
0.00
1.5
1.2
—
—
—
0
0
32
325
0.98
0.00
1.1
1.2
—
673.00
—
0
10
203
2035
1.00
0.00
1.9
1.5
2.31
2.51
g/l
0.86
126
1219
13
125
1.04
0.00
1.2
1.1
0.47
2.45
u/ml
—
7
58
21
215
0.98
0.00
1.5
1.6
1047.17
971.79
mu/l
0.12
15
179
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
451.39
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
78
0.90
-0.00
1.0
1.2
—
—
—
0
0
21
210
1.00
-0.00
5.7
4.3
2.72
2.62
mmol/l
0.06
15
140
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
17
170
1.00
-0.00
1.2
1.1
1.45
1.84
u/ml
0.13
11
92
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.06
—
0
5
14
140
1.00
-0.00
1.1
1.1
0.06
1.58
u/ml
—
6
71
6
67
0.89
-0.00
1.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
90
1.00
-0.00
1.4
1.1
97.89
103.77
pmol/l
—
9
90
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
49
1.02
-0.00
4.2
3.0
1493.80
872.08
u/ml
—
5
49
0
5
0.00
-0.00
0.0
1.0
—
177.40
—
0
5

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_CRANIAL_NERVE and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CRANIAL_NERVE 1.104 [0.96, 1.27] 0.176
Birth year 0.997 [0.99, 1.01] 0.544

During the follow-up period (1.1.1998 — 31.12.2019), 312 out of 2291 females with CD2_BENIGN_CRANIAL_NERVE died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_CRANIAL_NERVE 0.893 [0.77, 1.04] 0.151
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 1846 males with CD2_BENIGN_CRANIAL_NERVE died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CRANIAL_NERVE.

N-year risk Females Males
1 0.106% 0.216%
5 0.569% 1.193%
10 1.639% 2.809%
15 3.339% 5.148%
20 5.606% 8.77%

Relationships between endpoints

Index endpoint: CD2_BENIGN_CRANIAL_NERVE – Benign neoplasm: Cranial nerves

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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