Other demyelinating diseases of the central nervous system

G6_OTHDEMYEL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G37
  • Hospital discharge: ICD-9 341[1-9]
  • Hospital discharge: ICD-8 3410[2-9]
  • Cause of death: ICD-10 G37
  • Cause of death: ICD-9 341[1-9]
  • Cause of death: ICD-8 3410[2-9]

2 out of 7 registries used, show all original rules.

1634

4. Check minimum number of events

None

1634

5. Include endpoints

None

1634

6. Filter based on genotype QC (FinnGen only)

1486

Control definitions (FinnGen only)

Control exclude
G6_DEMYEL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G35-G37
Name in latin
Alii morbi demyelinantes systematis nervosi centralis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8543 5445 3043
Only index persons 7717 5057 2660
Unadjusted period prevalence (%)
Whole population 0.13 0.16 0.09
Only index persons 0.16 0.19 0.10
Median age at first event (years)
Whole population 39.82 38.63 41.86
Only index persons 39.14 38.08 41.15

-FinnGen-

Key figures

All Female Male
Number of individuals 1486 1079 407
Unadjusted period prevalence (%) 0.33 0.38 0.19
Median age at first event (years) 39.98 38.52 43.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1552
Matched controls
15520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N04BB01
ATC
amantadine; oral
42.2
317.0
193
52
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
+∞
307.7
1215
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
23.2
307.7
817
709
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
37.8
307.7
207
63
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
+∞
307.7
666
*
N86
ICPC
Multiple sclerosis
2326.3
307.7
347
*
109
Kela drug reimbursment
Multiple sclerosis
+∞
307.7
782
*
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
+∞
307.7
669
*
L03AB07
ATC
interferon beta-1a; parenteral
+∞
307.7
310
*
TAB00
NOMESCO Finland
Lumbar puncture
30.3
307.7
598
315
G35
ICD-10 Finland
Multiple sclerosis
8468.7
307.7
1043
*
H46
ICD-10 Finland
Optic neuritis
131.8
307.7
281
26
L03AX13
ATC
glatiramer acetate; parenteral
+∞
288.8
268
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
7.9
284.8
486
849
M03BX01
ATC
baclofen; systemic
20.5
257.5
203
113
L04AX07
ATC
dimethyl fumarate; oral
+∞
245.5
229
*
R20.2
ICD-10 Finland
Paraesthesia of skin
7.2
226.6
398
705
164
Kela drug reimbursment
Fingolimod
+∞
208.1
195
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
16.8
205.5
178
119
L04AA31
ATC
[U] teriflunomide
+∞
204.8
192
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
16.6
191.4
166
111
353
Kela drug reimbursment
Cladribine and fingolimod
+∞
189.6
178
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
24.4
180.1
130
58
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.1
179.0
201
205
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
7.2
170.9
283
464
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.6
144.8
320
690
XA800
NOMESCO Finland
Neuropsychological investigation
7.8
143.4
215
314
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
11.0
142.9
159
159
XKD06
NOMESCO Finland
Physiologic investigation of micturition
12.0
132.4
138
125
L04AA27
ATC
[U] fingolimod
+∞
132.2
125
*
L03AB08
ATC
interferon beta-1b; parenteral
+∞
130.1
123
*
XCK00
NOMESCO Finland
Perimetry
7.7
129.7
195
285
N07XX09
ATC
[U] dimethyl fumarate
+∞
129.0
122
*
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
29.3
128.2
86
31
G37.3
ICD-10 Finland
Acute transverse myelitis in demyelinating disease of central nervous system
+∞
121.5
115
*
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
22.4
120.0
89
42
G04BD12
ATC
mirabegron; oral
4.9
111.6
278
657
G04BD09
ATC
trospium; oral
15.4
109.1
97
67
N06BA07
ATC
modafinil; oral
38.3
106.7
66
18
L04AG12
ATC
ofatumumab; parenteral
+∞
104.4
99
*
2AB04, ,
NOMESCO Finland
157.5
98.4
103
7
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
14.2
96.1
89
66
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.4
95.3
437
1587
H53.2
ICD-10 Finland
Diplopia
7.6
93.1
138
197
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
10.8
92.4
102
100
L04AK02
ATC
teriflunomide; oral
+∞
90.5
86
*
ZX120
NOMESCO Finland
Intravenous
4.3
87.7
253
666
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
+∞
83.1
79
*
XKD00
NOMESCO Finland
Uroflowmetry
4.2
78.9
235
631
L03AB13
ATC
peginterferon beta-1a; parenteral
+∞
78.8
75
*
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
19.8
78.3
61
32
XKC03
NOMESCO Finland
Water cystometry
8.0
77.6
108
143
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
4.2
72.7
215
573
G37.2
ICD-10 Finland
Central pontine myelinolysis
+∞
70.3
67
*
UKC02
NOMESCO Finland
Cystoscopy
3.5
67.3
265
859
N03AX12
ATC
[U] gabapentin; oral
3.0
66.4
360
1413
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
+∞
62.9
60
*
3419X
ICD-9 Finland
Other demyelinating diseases of central nervous system, Demyelinating disease of central nervous system, unspecified
+∞
62.9
60
*
N03AE01
ATC
clonazepam; systemic
4.5
62.3
165
403
TKC22
NOMESCO Finland
Catheterisation instruction
10.0
62.3
72
75
G37.8
ICD-10 Finland
Other specified demyelinating diseases of central nervous system
+∞
61.9
59
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
15.5
61.6
54
36
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
9.3
61.5
75
84
L04AA40
ATC
cladribine; oral
+∞
59.8
57
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.3
59.4
164
413
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
12.6
55.8
55
45
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
17.8
55.1
45
26
R1250
NOMESCO Finland
Evaluation of functional capability
6.6
54.8
91
146
L04AA52
ATC
[U] ofatumumab; parenteral
+∞
54.5
52
*
G04BD08
ATC
solifenacin; oral
4.5
51.7
132
312
H02AB04
ATC
methylprednisolone; systemic
2.7
48.8
303
1261
N28
ICPC
Limited function/disability (N)
9.6
47.4
56
60
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.4
47.3
70
99
4AA23, ,
NOMESCO Finland
+∞
47.1
45
*
N99
ICPC
Neurological disease other
10.3
46.2
52
52
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
13.9
45.2
42
31
N03AX16
ATC
[U] pregabalin
2.4
45.1
415
2073
34109
ICD-8 Finland
Other demyelinating diseases of central nervous system, Unspecified
+∞
45.0
43
*
XKD03
NOMESCO Finland
Urethral pressure profilometry
7.2
44.7
67
96
N02BF01
ATC
gabapentin; oral
2.9
44.3
242
939
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
40.9
173
579
L04AE01
ATC
fingolimod; oral
+∞
40.8
39
*
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
4.9
39.1
89
191
L28
ICPC
Limited function/disability (L)
2.5
38.3
277
1232
C10AC01
ATC
colestyramine; oral
5.1
38.3
83
171
AA1AD
NOMESCO Finland
CT of head and brain
2.2
38.0
412
2183
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.2
37.8
166
567
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.0
37.1
81
168
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
36.8
683
4404
3400A
ICD-9 Finland
Multiple sclerosis[SCLEROSIS MULTIPLEX (DISSEMINATA)]
+∞
36.6
35
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
8.7
36.2
46
54
N29
ICPC
Neurological sympt/complt other
6.3
35.9
61
100
R33
ICD-10 Finland
Retention of urine
3.9
35.3
110
301
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.1
35.0
100
257
R35
ICD-10 Finland
Polyuria
3.4
34.3
130
405
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.8
34.3
111
312
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
33.5
32
*
G04BD04
ATC
oxybutynin; oral, transdermal
4.0
33.4
99
261
SPAT1229
SPAT
Assessment of need for aid
3.6
33.4
115
337
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.8
33.0
175
664
R4120
NOMESCO Finland
Occupational therapy
3.1
32.9
144
490
L04AX01
ATC
azathioprine; systemic
3.6
32.4
110
319
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
6.7
32.0
51
78
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
9.5
31.9
38
41
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
54.1
31.4
37
7
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.3
31.1
121
383
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
30.3
249
1165
CS494
NOMESCO Finland
Other visual field testing
5.5
30.1
59
111
A28
ICPC
Limited function/disability NOS
2.6
30.0
200
850
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
7.9
29.0
40
52
R4110
NOMESCO Finland
Physiotherapy
2.0
28.5
434
2569
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
28.3
420
2463
G36.0
ICD-10 Finland
Neuromyelitis optica [Devic]
+∞
28.2
27
*
N05CF01
ATC
zopiclone; oral
1.9
28.0
485
2993
TKC20
NOMESCO Finland
Catheterisation of bladder
3.5
28.0
102
310
J01EA01
ATC
trimethoprim; systemic
1.9
27.7
432
2574
G04BD07
ATC
tolterodine; oral
4.1
27.5
78
199
N06AX16
ATC
venlafaxine; oral
2.1
27.3
317
1700
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.4
26.8
208
947
R20.1
ICD-10 Finland
Hypoaesthesia of skin
8.9
26.3
33
38
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
52.7
26.3
31
6
N06AX21
ATC
duloxetine; oral
2.2
25.7
249
1243
G04BD11
ATC
fesoterodine; oral
5.8
25.6
47
83
G37.0
ICD-10 Finland
Diffuse sclerosis
+∞
25.1
24
*
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
24.8
24.4
34
14
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
5.5
23.9
46
85
R42
ICD-10 Finland
Dizziness and giddiness
1.9
23.7
339
1948
L04AX09
ATC
diroximel fumarate; oral
+∞
23.0
22
*
L01BB04
ATC
cladribine; systemic
+∞
23.0
22
*
34099
ICD-8 Finland
Multiple sclerosis
+∞
23.0
22
*
Z3226
NOMESCO Finland
Physiotherapist
2.0
22.9
288
1581
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
21.8
22.2
32
15
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
35.6
22.1
28
8
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
+∞
21.9
21
*
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
4.5
21.4
53
122
SPAT1231
SPAT
Assessment of adjustments needed in living environment
7.1
21.2
32
46
N03AF01
ATC
carbamazepine; oral, rectal
3.0
21.0
94
323
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.0
20.9
246
1316
R5110, ,
SPAT
2.6
20.8
129
527
Z3231
NOMESCO Finland
Registered nurse
1.8
20.8
405
2554
A02BC02
ATC
pantoprazole; systemic
1.7
20.5
1027
8318
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.1
20.5
86
285
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
20.3
183
884
R39.1
ICD-10 Finland
Other difficulties with micturition
4.1
20.1
56
141
Z2445
NOMESCO Finland
Psychologist
2.9
19.9
97
350
4AA36, ,
NOMESCO Finland
+∞
19.8
19
*
34108
ICD-8 Finland
Other demyelinating diseases of central nervous system, Alii definiti
+∞
19.8
19
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
19.4
122
502
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.5
19.1
65
189
G82.2
ICD-10 Finland
Paraplegia, unspecified
16.1
18.8
30
19
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.9
18.4
90
325
SPAT1216
SPAT
Assessment of functional ability
2.1
18.2
176
873
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
18.2
132
581
Z2446
NOMESCO Finland
Social worker
2.4
18.0
124
532
G37.1
ICD-10 Finland
Central demyelination of corpus callosum
+∞
17.7
17
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.8
17.6
89
328
G04CA02
ATC
tamsulosin; oral
2.1
17.3
185
953
R20.0
ICD-10 Finland
Anaesthesia of skin
5.8
17.1
31
54
G81.9
ICD-10 Finland
Hemiplegia, unspecified
5.6
17.0
32
58
G50.0
ICD-10 Finland
Trigeminal neuralgia
4.1
16.5
46
116
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.0
16.5
73
250
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
16.3
358
2316
U04
ICPC
Incontinence urine
2.9
16.2
79
285
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.3
15.8
127
584
U13
ICPC
Bladder symptom/complaint other
3.6
15.7
53
153
N06AA09
ATC
amitriptyline; systemic
2.2
15.7
140
671
G36.8
ICD-10 Finland
Other specified acute disseminated demyelination
+∞
15.6
15
*
N30.0
ICD-10 Finland
Acute cystitis
1.8
15.5
284
1744
RS221, ,
NOMESCO Finland
4.9
15.5
34
71
M03BX02
ATC
tizanidine; oral
1.6
15.3
1017
8498
N03AF02
ATC
oxcarbazepine; oral
2.9
15.0
69
241
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
12.6
14.9
26
21
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
4.6
14.7
35
78
RS222, ,
NOMESCO Finland
5.6
14.3
27
49
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
22.5
14.2
20
9
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
22.5
14.2
20
9
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.5
14.2
49
144
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.4
14.2
96
409
R4110, ,
SPAT
1.9
14.2
196
1102
N18
ICPC
Paralysis/weakness
4.7
14.0
32
69
G61.0
ICD-10 Finland
Guillain-Barré syndrome
12.8
13.9
24
19
R27.0
ICD-10 Finland
Ataxia, unspecified
24.0
13.8
19
8
R51.80
ICD-10 Finland
Headache
1.7
13.8
303
1951
H02AB07
ATC
prednisone; oral
1.9
13.8
188
1052
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
13.6
181
1003
G04.8
ICD-10 Finland
Other encephalitis, myelitis and encephalomyelitis
34.3
13.5
17
5
R26.0
ICD-10 Finland
Ataxic gait
40.4
13.2
16
*
H53.4
ICD-10 Finland
Visual field defects
3.7
13.0
40
109
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
4.0
12.8
36
92
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
10.1
12.5
24
24
H47.2
ICD-10 Finland
Optic atrophy
14.5
12.3
20
14
H02AB06
ATC
prednisolone; systemic
1.5
12.2
679
5362
XCK10
NOMESCO Finland
Photography of fundus of eye
2.1
12.2
114
557
H30.2
ICD-10 Finland
Posterior cyclitis
13.5
11.9
20
15
Z2221
NOMESCO Finland
Medical doctor
1.5
11.9
419
3010
R15
ICD-10 Finland
Faecal incontinence
3.4
11.7
42
127
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
3.9
11.7
34
89
J05AB11
ATC
valaciclovir; oral
1.7
11.7
235
1474
NA7CM
NOMESCO Finland
Spine and spinal cord extensive MRI examination with 3 Tesla magnet
65.5
11.6
13
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.4
11.5
79
339
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
9.3
11.5
23
25
R20.8
ICD-10 Finland
Other and unspecified disturbances of skin sensation
4.0
11.5
32
81
36703
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica, retrobulbaris
+∞
11.5
11
*
A06AD11
ATC
lactulose; oral
1.9
11.5
150
827
R60.0
ICD-10 Finland
Localized oedema
1.9
11.4
159
894
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
11.4
633
4977
6BA02, ,
NOMESCO Finland
15.2
11.3
18
12
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
11.2
156
877
R32
ICD-10 Finland
Unspecified urinary incontinence
3.4
11.1
39
116
U05
ICPC
Urination problems other
2.5
11.1
67
271
H57.1
ICD-10 Finland
Ocular pain
2.3
11.1
84
377
SPAT1167
SPAT
Insertion of urinary catheter
4.1
10.9
29
71
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.7
10.9
56
209
J01CA08
ATC
pivmecillinam; oral
1.4
10.9
660
5265
G97.1
ICD-10 Finland
Other reaction to spinal and lumbar puncture
17.9
10.7
16
9
H20.1
ICD-10 Finland
Chronic iridocyclitis
4.8
10.7
24
51
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.9
10.6
129
694
3773B
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS RETROBULBARIS]
110.8
10.4
11
*
N30.9
ICD-10 Finland
Cystitis, unspecified
2.1
10.3
104
524
G95.9
ICD-10 Finland
Disease of spinal cord, unspecified
18.9
10.3
15
8
N06AB04
ATC
citalopram; systemic
1.6
10.3
308
2127
NA1CM
NOMESCO Finland
Cervical spine extensive MRI examination with 3 Tesla magnet
13.2
10.2
17
13
K59.09
ICD-10 Finland
Constipation, unspecified
2.2
10.1
84
392
OAB50, ,
SPAT
2.0
10.1
110
570
U07
ICPC
Urine symptom/complaint other
2.0
10.1
110
570
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
9.9
136
761
WW400
NOMESCO Finland
Plasmaferesis
20.2
9.8
14
7
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.8
9.8
137
772
N02AX02
ATC
tramadol; systemic, rectal
1.4
9.7
558
4382
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.0
9.7
42
143
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
5.3
9.6
19
36
N02BF02
ATC
pregabalin; oral
2.0
9.6
109
572
Z43.5
ICD-10 Finland
Attention to cystostomy
15.1
9.5
15
10
G37.5
ICD-10 Finland
Concentric sclerosis [Baló]
+∞
9.4
9
*
3418X
ICD-9 Finland
Other demyelinating diseases of central nervous system
+∞
9.4
9
*
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
4.9
9.3
20
41
SPAT1293
SPAT
Other function in accordance with rehabilitation guidance nomenclature
8.7
9.3
19
22
U29
ICPC
Urinary symptom/complaint other
2.8
9.3
45
163
C03CA01
ATC
furosemide; systemic
1.6
9.2
228
1502
J01MA02
ATC
ciprofloxacin; systemic
1.4
9.2
484
3735
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.3
9.2
65
284
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.5
8.9
53
213
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.3
8.8
33
103
SPAT1301
SPAT
No procedures
1.5
8.7
385
2871
H25.8
ICD-10 Finland
Other senile cataract
2.2
8.6
72
337
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.1
8.6
35
115
H50.52
ICD-10 Finland
Exophoria
3.4
8.5
30
90
Z3229
NOMESCO Finland
Other healthcare associate professional
1.9
8.5
100
533
N06
ICPC
Sensation disturbance other
3.7
8.5
26
71
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
7.4
8.4
19
26
XA402
NOMESCO Finland
ENMG
2.7
8.4
44
166
N06AX11
ATC
mirtazapine; oral
1.4
8.4
489
3826
SPAT1263
SPAT
Sampling
1.4
8.3
574
4626
R4120, ,
SPAT
3.9
8.3
24
63
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
8.2
360
2676
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
8.2
273
1923
S97
ICPC
Chronic ulcer skin
2.3
8.2
63
286
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
4.6
8.1
19
42
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
8.1
130
763
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.2
8.1
67
313
J01MA12
ATC
levofloxacin; systemic
1.6
8.1
207
1375
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.1
8.0
72
347
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
8.0
95
507
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.5
8.0
229
1561
Z01.2
ICD-10 Finland
Dental examination
1.4
7.9
733
6168
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
7.8
7.9
17
22
RS121, ,
NOMESCO Finland
6.1
7.8
20
33
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
7.8
209
1400
U08
ICPC
Urinary retention
3.8
7.8
23
61
R52.2
ICD-10 Finland
Other chronic pain
2.2
7.7
64
299
N06AB10
ATC
escitalopram; oral
1.4
7.7
356
2667
H04.10
ICD-10 Finland
Dry eye syndrome
1.6
7.7
180
1170
N04BC05
ATC
pramipexole; oral
1.9
7.6
88
466
F10.25
ICD-10 Finland
Alcohol dependence continuous use
3.1
7.6
30
97
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
4.1
7.5
20
49
359
Kela drug reimbursment
Mirabegroni
10.1
7.5
14
14
N05BA01
ATC
diazepam; systemic, rectal
1.6
7.5
165
1057
H47.1
ICD-10 Finland
Papilloedema, unspecified
4.4
7.4
18
41
N04BD01
ATC
selegiline; oral
4.4
7.4
18
41
E87.6
ICD-10 Finland
Hypokalaemia
2.4
7.4
49
208
R25.2
ICD-10 Finland
Cramp and spasm
2.7
7.3
38
143
G04BD10
ATC
darifenacin; oral
8.4
7.3
15
18
A02BA02
ATC
ranitidine; systemic
1.5
7.3
209
1422
J01AA02
ATC
doxycycline; systemic
1.4
7.3
1114
10064
N05BA04
ATC
oxazepam; oral
1.4
7.3
366
2782
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
7.3
327
2436
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.2
7.3
19
46
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.2
1322
12317
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.6
7.2
176
1155
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
7.2
488
3898
R13
ICD-10 Finland
Dysphagia
1.9
7.2
91
497
Z93.5
ICD-10 Finland
Cystostomy status
30.2
7.1
9
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.6
7.1
158
1013
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
7.1
93
515
G51.0
ICD-10 Finland
Bell palsy
2.5
7.0
41
165
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.3
6.8
843
7343
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
6.8
340
2581
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.8
6.8
93
522
ZXA10
NOMESCO Finland
Bilateral
1.5
6.8
198
1354
SPAT1234
SPAT
Support of social functional capacity
2.2
6.7
55
256
G96.9
ICD-10 Finland
Disorder of central nervous system, unspecified
16.8
6.7
10
6
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.2
6.7
56
263
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
3.5
6.7
22
63
WX892
NOMESCO Finland
Monitored bed care
1.9
6.7
86
472
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
2.8
6.7
32
116
N03AX14
ATC
levetiracetam; systemic
2.5
6.6
40
163
XX1ZW
NOMESCO Finland
Very extensive written report from radiologist
7.8
6.6
14
18
RS340, ,
NOMESCO Finland
70.1
6.4
7
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.3
6.4
1111
10108
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
2.6
6.4
36
142
SPAT1262
SPAT
Handing over of treatment supplies
1.5
6.4
181
1230
119
Kela drug reimbursment
Trigeminal neuralgia or glossofaryngeusneuralgia
8.2
6.3
13
16
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.6
6.3
153
1002
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
5.5
6.3
17
31
G83.1
ICD-10 Finland
Monoplegia of lower limb
11.1
6.3
11
10
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
6.3
182
1241
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.6
6.3
158
1044
ABD40
NOMESCO Finland
Implantation of spinal injection device
+∞
6.3
6
*
G37.4
ICD-10 Finland
Subacute necrotizing myelitis
+∞
6.3
6
*
SPAT1312
SPAT
General health counselling
1.4
6.2
424
3375
R50.9
ICD-10 Finland
Fever, unspecified
1.5
6.2
206
1444
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
6.2
236
1701
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
4.0
6.2
17
43
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
2.8
6.1
30
110
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
6.1
263
1939
R93.0
ICD-10 Finland
Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
12.6
6.1
10
8
-50
ICPC
Medication/prescr/renewal
2.2
6.1
48
221
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
2.6
6.1
33
128
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.4
6.1
38
158
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
10.1
6.0
11
11
NA1DG
NOMESCO Finland
Cervical spine very extensive MRI examination with high intensity magnet
10.1
6.0
11
11
SPAT1254
SPAT
Administration of medicine
1.6
6.0
150
989
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.0
120
750

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
377
139
35.50
307.65
1.1
1.1
—
—
—
0
0
406
321
16.77
307.65
1.2
1.6
640.48
1693.30
e6/l
0.53
310
252
417
106
53.43
307.65
1.1
1.1
220.61
228.35
mg/l
0.18
372
90
402
314
16.93
307.65
1.2
1.5
38.40
15.78
e6/l
0.35
289
239
705
1100
10.91
307.65
4.0
2.7
10.14
10.69
g/l
3.27
657
1024
409
229
23.89
307.65
1.2
1.2
—
—
—
0
0
427
114
51.29
307.65
1.2
1.2
50.38
35.87
mg/l
2.71
348
95
423
288
19.82
307.65
1.2
1.6
—
—
—
0
0
343
92
47.58
307.65
1.3
1.2
0.97
0.53
ratio
14.83
163
57
395
326
15.91
307.65
1.2
1.3
3.52
3.69
mmol/l
1.88
375
310
481
354
19.24
307.65
1.2
1.4
433.45
502.98
mg/l
1.53
470
338
165
26
70.89
302.85
1.0
1.0
—
—
—
0
0
159
25
70.75
291.81
1.0
1.0
4.97
5.61
mg/g
0.58
150
25
214
103
23.94
289.71
3.7
2.1
1404.98
1332.26
e6/l
0.36
183
93
183
74
27.90
264.51
4.0
2.2
253.72
208.06
e6/l
1.57
152
65
170
71
26.77
242.51
4.0
2.1
447.81
590.71
e6/l
1.26
137
59
177
84
23.66
240.23
1.2
1.0
1531.10
1531.27
miu/ml
0.00
177
84
498
1055
6.48
237.92
2.6
2.4
26.25
19.74
au/ml
0.59
32
147
478
986
6.56
234.47
1.4
1.3
26.78
39.16
au/ml
0.36
11
67
442
863
6.76
228.86
3.5
1.7
1.17
1.37
g/l
1.07
436
805
129
27
52.02
223.75
2.7
1.5
0.04
0.21
e9/l
1.86
37
14
203
154
15.01
218.96
1.3
1.8
—
—
—
0
0
1016
4372
4.83
198.48
11.6
6.4
—
—
—
0
0
152
108
15.49
169.32
1.1
1.5
1.75
1.96
mmol/l
1.24
146
100
1180
6482
4.42
146.62
12.9
6.5
9.06
8.43
%
13.80
1160
6136
1177
6471
4.39
145.64
12.9
6.4
2.94
2.79
%
1.85
1157
6112
1174
6461
4.35
144.59
12.9
6.4
0.77
0.69
%
6.33
1154
6086
1236
7096
4.64
142.27
13.4
6.3
0.57
0.55
e9/l
2.53
1125
6236
1235
7104
4.62
141.30
13.3
6.4
0.04
0.04
e9/l
0.12
1124
6237
1188
6708
4.29
138.07
12.9
6.3
26.91
29.06
%
11.59
1169
6406
1170
6599
4.14
134.67
12.6
6.2
58.37
56.66
%
6.67
1155
6334
1239
7280
4.48
134.06
13.3
6.4
1.73
1.97
e9/l
13.02
1134
6559
1243
7354
4.47
132.30
13.4
6.7
0.19
0.18
e9/l
0.16
1138
6569
94
41
24.34
130.92
2.5
2.0
25.67
31.98
%
1.55
94
41
98
64
16.28
113.64
1.1
1.6
88.06
74.40
%
—
18
10
1246
7851
3.98
109.74
14.3
9.6
3.82
4.01
e9/l
2.78
1130
6915
430
1433
3.77
108.58
1.5
1.5
—
—
—
0
0
621
2625
3.28
107.28
3.6
2.4
4.87
7.05
e6/l
3.82
588
2378
780
3882
3.03
99.51
4.8
2.9
20.75
94.54
e6/l
2.11
654
2892
704
3342
3.03
97.33
4.5
2.8
0.14
0.32
e6/l
5.38
577
2370
922
5252
2.86
87.91
4.2
4.8
37.42
36.81
g/l
2.85
875
4975
527
2239
3.05
87.15
3.6
2.6
535.72
524.75
mosm/kgh2o
0.53
492
1964
854
4724
2.80
85.35
5.9
3.5
65.62
76.48
e6/l
0.22
688
3144
993
6168
2.69
75.07
2.8
2.5
86.01
74.39
nmol/l
23.35
935
5775
1238
8652
3.13
73.68
8.2
4.0
44.55
1123.96
e6/l
0.88
11
95
67
48
14.54
73.61
1.1
1.1
116.26
391.08
ng/l
0.48
27
12
478
2144
2.78
69.05
1.6
1.6
—
—
—
0
0
958
6119
2.48
63.91
15.7
10.2
0.00
0.00
e9/l
0.47
797
5030
1084
7339
2.58
63.50
5.8
3.4
0.00
0.01
estimate
1.79
285
1409
1072
7239
2.55
62.82
5.8
3.4
0.00
0.00
estimate
0.26
289
1493
1078
7302
2.56
62.70
5.8
3.4
0.00
6.18
estimate
1.83
293
1501
644
3508
2.43
60.50
4.3
2.5
—
—
—
0
0
909
5856
2.33
56.72
4.5
3.1
6.27
6.19
ph
1.44
472
3474
161
435
4.01
52.92
1.4
1.3
—
—
—
0
0
600
3356
2.28
51.02
1.8
1.7
—
—
—
0
0
226
785
3.20
50.58
1.9
2.8
68.29
68.03
g/l
0.21
215
746
374
1735
2.52
48.23
1.8
2.1
29.15
29.15
s
0.01
358
1687
406
2012
2.38
44.90
4.0
2.6
0.92
1.17
e6/l
0.39
226
1001
207
749
3.04
42.88
3.0
1.9
—
—
—
0
0
272
1153
2.65
41.78
6.6
5.0
0.02
0.40
%
0.65
54
252
269
1139
2.65
41.38
6.0
4.5
0.25
0.72
%
4.50
59
308
602
3602
2.10
41.12
2.6
2.1
139.66
182.42
u/l
1.10
579
3447
268
1138
2.64
40.97
6.3
4.7
0.02
0.15
%
3.90
51
273
276
1191
2.60
40.82
6.2
4.6
0.73
1.06
%
0.74
59
327
438
2326
2.23
40.57
1.4
1.4
427.45
520.59
titre
0.83
102
473
557
3307
2.07
38.24
2.3
1.4
2.12
2.29
g/l
2.32
433
2203
101
247
4.30
37.76
3.8
4.0
3.88
4.13
e9/l
0.59
101
247
175
619
3.06
37.55
2.6
2.0
0.02
1.14
estimate
0.50
41
223
58
88
6.81
36.71
4.3
2.6
49.98
44.84
%
1.19
46
43
363
1856
2.25
36.38
4.3
2.7
5.24
3.02
e6/l
1.83
183
849
72
138
5.42
36.00
1.2
1.8
—
—
—
0
0
991
7323
1.98
35.13
5.7
4.8
6.18
6.48
mmol/l
5.44
947
6804
613
3864
1.97
34.79
6.7
3.5
0.00
0.01
estimate
1.49
289
1424
632
4052
1.94
33.89
2.1
2.1
—
—
—
0
0
110
318
3.65
32.56
3.7
3.8
59.98
57.93
%
1.01
110
318
905
6659
1.86
30.50
5.6
6.3
9.64
10.52
umol/l
3.45
881
6352
1219
9939
2.06
29.49
7.5
7.9
73.53
75.23
u/l
0.86
1168
9505
133
465
3.03
28.95
1.3
1.3
—
—
—
0
0
717
4982
1.82
28.39
8.0
9.3
1.09
1.13
inr
1.78
602
4110
160
628
2.73
28.14
1.9
2.4
—
—
—
0
0
245
1188
2.26
27.26
2.5
2.0
0.00
0.03
estimate
1.05
49
276
236
1137
2.27
26.63
7.0
3.4
—
—
—
0
0
726
5138
1.78
26.40
7.1
6.3
1.22
1.21
mmol/l
0.41
666
4813
329
1820
2.02
25.92
3.5
3.1
4.06
4.99
e9/l
1.69
299
1635
797
5831
1.75
25.50
7.8
6.8
1.22
1.21
mmol/l
0.63
651
5080
224
1093
2.23
24.40
2.7
2.3
683.34
6182.57
u/l
7.40
65
460
539
3627
1.74
22.40
9.5
4.5
—
—
—
0
0
157
694
2.40
21.44
2.1
1.9
5.71
6.58
iu/ml
0.15
31
173
488
3240
1.74
20.99
4.1
3.8
96.61
95.35
%
0.60
476
3159
1481
13575
2.99
19.53
17.8
12.9
18.61
20.78
mg/l
1.94
1241
10989
119
489
2.55
18.98
1.7
1.8
0.23
0.23
g/l
0.08
114
461
506
3495
1.66
18.29
3.7
4.0
7.40
7.40
ph
1.07
364
2460
121
513
2.47
18.06
1.7
1.8
1.18
1.19
g/l
0.32
116
483
587
4222
1.63
18.01
5.3
2.8
0.00
0.05
estimate
0.65
270
1230
738
5617
1.60
17.86
6.2
3.2
0.02
0.02
estimate
0.08
271
1241
558
4009
1.61
16.94
7.6
6.0
—
—
—
0
0
66
217
3.13
15.96
1.3
1.9
—
1724.44
—
0
9
1453
13365
2.37
15.95
17.7
13.5
139.61
139.62
mmol/l
0.05
1428
13126
1454
13385
2.37
15.80
17.8
13.7
3.92
3.93
mmol/l
1.48
1426
13118
674
5178
1.53
14.68
2.0
1.9
97.48
98.24
pmol/l
0.15
382
2854
35
79
4.51
14.52
1.7
3.9
601.49
757.19
u/ml
0.29
35
79
169
918
1.94
13.52
3.6
2.2
0.18
0.31
e6/l
0.86
164
867
414
2934
1.56
12.60
4.6
4.1
—
—
—
0
0
568
4337
1.49
12.07
3.3
3.0
20.18
46.30
ng/l
0.91
328
2418
500
3725
1.50
11.97
3.1
2.9
—
0.78
—
0
9
632
4947
1.47
11.77
3.9
3.4
28.29
30.42
u/l
0.98
612
4708
1510
14351
2.93
11.62
21.1
15.3
69.37
71.11
umol/l
1.59
1501
14223
1508
14341
2.82
11.23
17.7
10.7
26.37
26.19
u/l
0.19
1485
14068
296
1994
1.60
11.04
3.3
3.5
0.82
0.82
mmol/l
0.03
281
1908
75
329
2.34
10.43
1.8
2.0
11.10
10.71
g/l
0.21
70
309
110
565
2.02
10.32
1.7
1.3
—
—
—
0
0
47
165
2.91
10.23
1.5
1.4
2.88
3.05
g/l
0.18
34
114
47
165
2.91
10.23
1.5
1.4
6.26
6.67
g/l
0.33
34
115
47
165
2.91
10.23
1.5
1.4
0.30
0.38
g/l
1.33
34
114
47
167
2.87
10.01
1.5
1.4
—
—
—
0
0
1159
10355
1.47
9.67
4.7
3.2
40.92
40.25
u/l
0.12
1110
9969
14
8
17.64
9.40
1.3
4.0
—
—
—
0
0
62
268
2.37
8.95
1.6
1.7
0.59
0.73
g/l
0.55
47
207
87
434
2.06
8.86
1.3
1.3
55.00
96.61
titre
—
10
56
238
1599
1.58
8.86
1.6
1.6
1129.41
1185.62
nmol/l
0.28
178
1270
419
3167
1.44
8.83
1.7
1.6
19.04
20.35
nmol/l
1.16
374
2788
98
520
1.94
8.41
1.3
1.3
95.40
29.18
u/ml
—
5
27
150
913
1.71
8.24
3.0
3.4
1.22
1.23
mmol/l
0.39
129
792
1378
12883
1.62
8.22
6.1
5.4
1.72
1.78
mu/l
1.25
1313
12292
208
1385
1.58
8.02
4.3
4.1
31.13
31.56
%
0.24
154
1024
1119
12151
0.72
7.56
25.6
16.0
332.39
332.82
g/l
0.96
1114
12082
26
77
3.42
7.54
1.3
1.6
136.15
140.45
nmol/l
0.21
26
77
66
316
2.14
7.52
2.0
2.9
1.49
2.10
index
0.48
35
173
511
4100
1.37
7.36
2.6
2.7
52.59
57.70
u/l
2.36
476
3856
1276
13521
0.68
7.13
4.4
4.4
1.49
1.48
mmol/l
0.26
1191
12929
34
124
2.78
6.98
1.1
1.1
131.47
114.12
pmol/l
0.70
34
124
222
1546
1.51
6.96
2.5
2.8
6.23
7.14
umol/l
0.57
195
1345
12
11
10.98
6.80
1.1
1.1
—
—
—
0
0
158
1034
1.59
6.55
4.6
3.6
7.36
7.35
ph
0.16
108
772
87
484
1.84
6.52
1.3
1.3
2.14
2.67
u/ml
—
7
46
60
298
2.05
6.26
1.1
1.1
—
—
—
0
0
207
1460
1.48
6.08
2.3
2.2
365.69
374.75
nmol/l
0.30
194
1379
1286
13552
0.70
6.08
4.4
4.5
4.75
4.77
mmol/l
0.40
1208
13014
207
1462
1.48
6.04
6.6
6.0
1.02
1.04
mmol/l
0.46
193
1374
86
489
1.80
6.03
1.3
1.3
4.31
8.78
u/ml
0.71
11
77
30
113
2.69
5.84
1.1
1.2
—
—
—
0
0
54
265
2.08
5.84
1.5
2.0
—
8.17
—
0
6
1208
12840
0.73
5.76
3.8
3.8
1.24
1.27
mmol/l
0.61
1125
12219
1301
13662
0.70
5.70
4.8
4.9
2.84
2.84
mmol/l
0.01
1209
13075
255
1898
1.41
5.61
2.6
2.3
2.40
2.41
g/l
0.10
241
1773
549
6450
0.77
5.58
2.7
2.7
—
—
—
0
0
86
502
1.75
5.54
2.2
1.8
—
—
—
0
0
18
52
3.49
5.46
4.1
2.5
—
—
—
0
0
54
275
2.00
5.31
1.4
1.3
7.05
5.37
u/ml
0.19
22
119
231
1712
1.41
5.20
2.6
2.4
23.85
24.08
%
0.08
215
1606
137
916
1.54
5.19
7.5
8.2
7.30
8.07
mmol/l
0.99
132
886
1270
11919
1.36
5.12
24.8
15.6
13.37
13.39
%
0.36
1258
11783
270
2060
1.38
5.11
2.6
2.4
13.90
14.40
umol/l
0.51
257
1937
12
19
6.36
5.08
1.1
1.0
87.00
61.83
%
—
6
6
227
1686
1.41
5.04
1.4
1.4
—
—
—
0
0
47
232
2.06
5.04
1.7
1.3
—
10.40
—
0
5
157
1098
1.48
4.82
2.3
2.4
0.22
0.22
g/l
0.04
150
1041
177
1273
1.44
4.70
1.2
1.2
—
—
—
0
0
501
4217
1.28
4.69
2.6
3.3
2.34
2.35
mmol/l
0.65
458
3934
160
2212
0.69
4.66
1.9
1.9
3.37
3.43
ratio
0.30
122
1661
37
175
2.14
4.46
1.6
1.7
—
—
—
0
0
66
385
1.75
4.32
2.0
2.0
2.42
2.21
ug/l
0.04
51
350
117
788
1.52
4.32
1.2
1.3
228.36
221.74
miu/ml
0.07
49
413
40
198
2.05
4.30
2.4
2.3
—
—
—
0
0
18
61
2.97
4.29
4.1
2.5
—
—
—
0
0
117
791
1.52
4.25
2.9
2.8
67.31
74.37
e9/l
1.49
78
562
66
388
1.73
4.21
2.1
1.9
1.37
1.41
g/l
0.13
58
344
46
243
1.92
4.14
3.3
3.6
2.15
1.99
ratio
0.07
18
138
50
272
1.87
4.12
3.4
3.9
25.37
38.83
mg/l
1.07
44
234
50
272
1.87
4.12
3.4
3.9
33.90
37.99
mg/l
0.30
44
235
31
143
2.19
4.00
1.1
1.1
—
—
—
0
0
1196
11244
1.28
3.96
4.9
4.6
14.75
14.40
pmol/l
5.22
1111
10649
76
473
1.64
3.95
4.1
3.4
—
—
—
0
0
301
2424
1.30
3.90
1.6
1.6
461.00
31096000.23
pmol/l
2.45
258
2145
204
1556
1.36
3.85
2.6
1.6
—
—
—
0
0
121
1701
0.69
3.85
1.6
1.7
3.43
3.49
mmol/l
0.23
79
1160
75
1161
0.63
3.82
1.6
1.7
—
—
—
0
0
270
2149
1.31
3.81
3.4
3.4
216.26
487.75
ng/l
1.08
145
1314
381
3170
1.27
3.81
6.2
3.4
1.02
1.50
kg/l
0.50
278
2082
227
1764
1.34
3.79
2.2
1.9
—
—
—
0
0
24
102
2.37
3.75
3.8
3.6
—
—
—
0
0
19
72
2.66
3.73
2.0
1.9
2.45
2.43
u/field
0.01
11
42
391
3278
1.26
3.65
1.8
1.8
0.87
0.94
mg/l
0.23
267
2479
152
2027
0.72
3.56
1.3
1.3
—
—
—
0
0
10
21
4.79
3.55
2.1
1.0
—
—
—
0
0
100
682
1.50
3.53
3.9
3.2
7.43
7.42
ph
1.42
86
577
28
131
2.16
3.52
1.1
1.1
—
—
—
0
0
50
291
1.74
3.37
1.1
1.1
—
—
—
0
0
8
14
5.74
3.34
1.5
1.1
—
—
—
0
0
15
54
2.80
3.25
1.0
1.4
79.90
89.49
nmol/l
—
10
43
154
1155
1.37
3.25
13.4
9.6
12.68
12.97
kpa
0.31
144
1116
154
1155
1.37
3.25
13.4
9.6
5.01
5.08
kpa
0.42
143
1114
33
170
1.96
3.25
1.4
1.4
47.76
67.05
mmol/l
2.79
25
147
40
220
1.84
3.25
2.6
3.0
2.50
2.24
mmol/l
0.32
31
136
50
295
1.72
3.22
1.7
2.3
—
—
—
0
0
35
185
1.91
3.21
1.5
1.2
—
—
—
0
0
12
34
3.55
3.20
1.0
2.3
44.01
43.24
g/l
0.26
12
34
147
1105
1.36
3.07
3.6
2.6
1.67
1.81
%
1.24
130
1005
8
16
5.02
3.05
1.5
1.1
—
—
—
0
0
151
1146
1.35
2.98
13.5
9.7
1.08
0.76
mmol/l
0.48
118
933
37
206
1.82
2.92
3.8
7.1
353.82
368.36
umol/l
0.20
32
185
388
3326
1.22
2.89
2.5
2.2
2.68
2.66
mg/l
0.05
344
2926
151
1153
1.34
2.87
13.6
9.7
7.43
7.41
ph
0.99
80
630
21
421
0.49
2.76
1.0
1.1
0.20
1.60
u/ml
4.46
12
200
442
3853
1.21
2.76
1.4
1.3
1.29
1.54
u/ml
0.20
109
1135
1522
14983
1.82
2.75
31.5
19.7
266.70
260.97
e9/l
2.95
1509
14789
77
528
1.48
2.71
1.2
1.2
—
—
—
0
0
1522
14990
1.79
2.64
31.3
19.6
90.79
90.42
fl
2.98
1512
14901
12
41
2.94
2.62
3.4
1.4
13.78
17.71
umol/l
2.40
12
33
1522
14992
1.79
2.61
31.2
19.6
30.25
30.17
pg
1.01
1512
14903
25
127
1.98
2.61
1.0
1.1
—
—
—
0
0
1522
14993
1.78
2.59
31.4
19.7
4.52
4.54
e12/l
0.89
1507
14776
1522
14993
1.78
2.59
32.1
20.1
40.68
40.99
%
0.47
1512
14898
1522
14996
1.77
2.55
31.5
19.8
6.62
6.71
e9/l
0.64
1506
14767
1522
14998
1.77
2.52
31.6
19.8
135.79
136.17
g/l
0.60
1512
14907
17
75
2.28
2.51
1.4
1.6
27.47
29.09
umol/l
0.32
17
65
7
16
4.39
2.47
2.0
2.4
0.43
0.94
u/field
—
7
16
79
556
1.44
2.46
1.9
2.1
20.49
20.50
s
0.01
68
483
10
32
3.14
2.43
3.8
2.2
—
—
—
0
0
28
490
0.56
2.41
1.1
1.1
0.74
2.57
u/ml
1.85
13
248
205
2487
0.80
2.38
1.5
1.5
—
—
—
0
0
19
92
2.08
2.27
1.5
1.2
—
—
—
0
0
35
209
1.69
2.24
2.5
2.2
17.11
16.80
%
0.23
35
204
125
969
1.32
2.19
15.6
10.6
122.86
123.14
g/l
0.06
120
951
617
5639
1.16
2.08
2.1
2.0
—
—
—
0
0
17
326
0.52
2.03
1.1
1.0
0.17
0.22
u/ml
—
7
98
20
104
1.94
2.00
1.5
1.4
18.73
27.52
umol/l
0.83
20
95
21
375
0.55
1.99
1.0
1.1
2.38
2.93
u/ml
0.16
13
182
23
126
1.84
1.98
2.3
2.6
—
—
—
0
0
7
21
3.34
1.96
1.1
2.2
—
—
—
0
0
129
1021
1.29
1.96
14.8
10.3
96.46
96.14
%
0.27
122
996
140
1121
1.27
1.94
3.2
2.0
6.29
6.10
ph
1.22
72
693
8
27
2.97
1.93
1.0
1.1
—
—
—
0
0
29
173
1.69
1.90
1.5
1.4
292.60
389.78
pmol/l
0.58
24
150
302
2628
1.19
1.88
2.5
3.1
634.90
770.61
ng/l
0.50
251
2165
98
756
1.32
1.82
1.9
1.6
0.29
0.31
mg/l
0.09
53
349
50
344
1.47
1.82
1.1
1.3
310.88
247.06
u/ml
0.52
33
220
48
328
1.48
1.80
1.3
1.4
—
—
—
0
0
36
232
1.56
1.77
3.3
2.8
—
—
—
0
0
62
843
0.72
1.73
1.2
1.1
0.89
0.90
g/l
0.10
62
843
61
441
1.40
1.72
7.3
7.1
1.81
1.60
%
0.71
56
415
34
218
1.57
1.71
1.2
1.3
—
65.92
—
0
13
25
148
1.70
1.71
2.7
2.5
—
—
—
0
0
0
47
0.00
1.70
0.0
2.0
—
82.73
—
0
7
45
308
1.47
1.69
1.4
1.4
158.75
153.91
au/ml
—
8
90
28
440
0.63
1.66
1.1
1.1
2.92
5.73
u/ml
1.05
15
240
26
415
0.62
1.65
1.1
1.1
0.21
1.24
u/ml
2.15
11
176
80
611
1.33
1.62
1.2
1.3
—
—
—
0
0
21
349
0.60
1.58
1.0
1.1
3.56
4.10
u/ml
0.11
11
149
22
129
1.72
1.57
2.8
2.6
1.80
1.28
g/24h
0.29
11
84
149
1236
1.23
1.56
1.3
1.3
96.36
223.77
u/ml
3.66
135
1155
62
826
0.74
1.54
1.2
1.1
1.58
1.55
g/l
0.51
62
826
6
21
2.86
1.50
1.8
2.5
—
—
—
0
0
292
2587
1.16
1.47
1.6
1.8
—
—
—
0
0
59
783
0.74
1.44
1.1
1.1
0.49
0.62
ratio
—
10
83
79
614
1.30
1.44
2.2
3.0
110.85
142.15
ng/l
0.34
70
544
23
141
1.64
1.42
1.7
1.7
269.31
281.81
mosm/kgh2o
0.59
16
111
9
40
2.26
1.40
1.0
1.3
—
—
—
0
0
10
46
2.18
1.40
1.0
1.1
—
—
—
0
0
10
46
2.18
1.40
1.0
1.1
—
—
—
0
0
10
46
2.18
1.40
1.0
1.1
—
—
—
0
0
7
29
2.42
1.39
2.3
1.4
—
—
—
0
0
124
1023
1.23
1.39
4.6
3.6
7.38
7.38
ph
0.11
71
580
54
399
1.37
1.38
8.1
7.6
0.91
0.90
%
0.07
49
372
55
410
1.35
1.34
3.4
3.8
410.52
298.52
mg/l
0.45
23
180
116
1399
0.82
1.33
3.3
2.8
0.68
0.69
ug/l
0.10
80
776
102
832
1.24
1.28
4.6
3.8
87.72
79.11
ng/l
0.38
90
748
49
655
0.74
1.28
1.4
1.5
—
—
—
0
0
152
1292
1.20
1.28
2.7
2.5
33.73
41.24
u/l
0.82
133
1096
75
591
1.28
1.26
8.4
8.3
24.21
24.30
mmol/l
0.07
69
565
73
921
0.78
1.26
1.2
1.1
—
—
—
0
0
37
262
1.42
1.23
1.1
1.2
—
—
—
0
0
118
985
1.21
1.21
4.4
3.5
1.45
1.76
mmol/l
0.45
107
852
6
26
2.31
1.18
1.2
1.0
—
—
—
0
0
22
141
1.57
1.17
1.0
1.1
—
—
—
0
0
15
87
1.73
1.15
1.7
1.1
—
—
—
0
0
7
31
2.26
1.10
1.1
1.3
55.29
69.65
ug/l
—
7
31
19
120
1.59
1.08
1.1
1.0
—
—
—
0
0
16
97
1.66
1.06
2.6
2.4
—
—
—
0
0
50
644
0.77
1.05
1.4
1.5
1.25
1.29
mm
0.30
37
447
49
376
1.31
1.04
1.1
1.4
27.54
22.89
u/l
0.51
38
312
9
48
1.88
1.00
3.4
1.5
—
—
—
0
0
53
669
0.78
0.96
1.4
1.5
—
—
—
0
0
796
7630
1.09
0.93
3.4
3.2
101.09
89.96
ug/l
0.50
763
7285
125
1436
0.86
0.89
1.5
1.6
1014.46
1034.65
mu/l
0.08
103
1185
66
539
1.23
0.88
2.5
2.1
—
—
—
0
0
23
161
1.44
0.86
1.7
1.3
0.15
0.28
nmol/l
0.52
18
112
27
196
1.38
0.84
2.2
2.2
—
—
—
0
0
42
327
1.29
0.84
8.1
8.6
1.14
1.25
mmol/l
0.40
36
284
49
391
1.26
0.81
1.8
1.8
—
—
—
0
0
49
391
1.26
0.81
1.1
1.1
—
—
—
0
0
13
81
1.61
0.81
2.4
1.9
—
—
—
0
0
0
24
0.00
0.79
0.0
2.1
—
1.19
—
0
24
8
48
1.67
0.78
2.0
1.5
—
—
—
0
0
71
845
0.83
0.78
1.5
1.5
63.98
59.59
ug/l
0.32
61
695
9
53
1.70
0.75
1.2
1.8
76.00
105.71
ng/l
—
9
53
12
185
0.65
0.75
1.8
1.6
—
—
—
0
0
32
414
0.77
0.75
7.5
8.2
—
—
—
0
0
5
24
2.09
0.74
1.4
1.4
6.00
5.67
mmol/l
—
5
24
203
1845
1.12
0.74
1.3
1.2
—
—
—
0
0
238
2184
1.11
0.73
2.3
2.6
98.41
105.26
ug/g
0.17
177
1772
329
3523
0.92
0.73
4.9
4.2
16.00
8.92
mg/mmol
0.71
209
2235
5
25
2.00
0.72
1.4
1.2
—
—
—
0
0
5
25
2.00
0.72
1.2
3.5
13.60
4.68
ug/l
—
5
25
22
159
1.39
0.72
1.6
1.4
—
—
nmol/l
—
0
0
7
39
1.80
0.72
1.1
1.1
—
—
—
0
0
66
554
1.20
0.71
3.5
2.6
1.02
1.02
ratio
0.01
57
499
7
40
1.75
0.71
1.0
1.1
0.01
0.11
u/ml
—
7
40
103
899
1.16
0.71
18.1
10.0
—
—
—
0
0
48
391
1.23
0.70
1.1
1.1
—
—
—
0
0
9
58
1.55
0.69
3.4
1.2
0.00
0.00
estimate
—
9
58
81
939
0.86
0.68
1.6
1.7
333.40
292.17
mu/l
0.36
72
850
5
27
1.85
0.68
2.0
1.7
2.00
2.61
%
—
5
27
1224
12453
0.92
0.68
5.2
5.2
37.18
37.93
mmol/mol
2.57
1148
11939
55
456
1.21
0.68
1.1
1.2
—
—
—
0
0
383
4062
0.92
0.67
4.2
3.4
7.56
8.03
mmol/l
1.07
321
3558
35
276
1.27
0.67
3.3
3.1
68.37
63.87
%
0.63
35
271
329
3080
1.09
0.67
1.3
1.3
19.81
26.40
iu/ml
0.58
73
896
15
214
0.70
0.66
1.1
1.4
—
—
—
0
0
39
483
0.80
0.66
1.3
1.8
37.69
40.10
nmol/l
0.38
39
470
98
860
1.15
0.64
1.3
1.2
—
—
—
0
0
35
278
1.26
0.64
1.2
1.2
—
—
—
0
0
5
29
1.73
0.64
1.2
1.5
1.63
3.64
mmol/l
—
5
23
5
30
1.67
0.61
1.0
1.1
0.02
0.02
u/ml
—
5
30
327
3472
0.93
0.60
4.2
3.6
71.11
49.21
mg/l
0.60
208
2246
37
454
0.81
0.59
1.4
1.4
0.41
0.45
nmol/l
0.18
27
367
8
52
1.54
0.59
1.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
150
1362
1.11
0.59
1.3
1.2
152.75
143.88
u/ml
0.10
57
537
348
3285
1.08
0.58
2.5
2.4
301.58
323.18
umol/l
4.60
311
2989
15
106
1.42
0.57
1.1
1.6
—
—
—
0
0
6
35
1.72
0.57
1.5
3.0
54.83
47.06
%
—
6
35
6
35
1.72
0.57
3.0
6.0
5.17
8.06
%
—
6
35
9
61
1.48
0.53
1.6
1.7
84.89
79.29
nmol/24h
—
9
61
26
205
1.27
0.52
3.3
2.4
93.36
90.45
%
3.39
26
198
12
83
1.45
0.52
1.2
1.3
4.69
6.17
mmol/l
1.20
12
76
235
2202
1.08
0.49
2.2
2.5
2.43
2.42
mmol/l
0.17
210
1981
26
323
0.80
0.49
2.7
2.3
3.66
5.35
umol/l
1.44
21
237
16
119
1.35
0.48
1.4
1.9
1.01
0.95
%
0.16
11
71
18
232
0.77
0.46
2.9
3.5
39.64
23.38
mg/l
0.55
11
167
57
651
0.87
0.44
1.1
1.3
12.00
10.49
u/l
0.32
48
539
46
395
1.17
0.44
1.3
1.3
—
—
—
0
0
24
193
1.25
0.43
1.5
1.4
—
—
—
0
0
24
193
1.25
0.43
1.5
1.4
—
—
—
0
0
24
193
1.25
0.43
1.5
1.4
—
—
—
0
0
24
193
1.25
0.43
1.5
1.4
—
—
—
0
0
116
1061
1.10
0.43
3.4
3.6
4.47
4.59
pmol/l
0.84
103
960
5
33
1.52
0.41
1.4
1.2
—
0.43
—
0
6
12
88
1.37
0.40
3.8
3.0
781.00
1300.33
mg
0.90
12
88
0
18
0.00
0.40
0.0
1.0
—
0.26
—
0
9
8
61
1.31
0.39
1.4
1.4
—
—
—
0
0
26
214
1.22
0.39
1.2
1.3
—
—
—
0
0
34
288
1.18
0.39
2.4
1.6
402.73
349.46
mu/l
0.28
26
235
14
106
1.32
0.39
1.2
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
164
1535
1.08
0.38
1.4
1.4
—
—
—
0
0
9
70
1.29
0.36
1.3
1.4
—
—
—
0
0
9
71
1.27
0.36
1.9
2.6
1843.33
2011.02
ml
—
9
66
88
962
0.91
0.36
3.5
4.7
5.42
17.27
ug/l
1.03
65
737
77
699
1.11
0.35
5.2
2.7
—
—
—
0
0
15
117
1.28
0.35
3.0
2.3
20.25
32.30
mg/l
—
8
85
21
255
0.82
0.35
2.4
2.6
37.21
112.33
ug/min
1.42
15
155
114
1056
1.09
0.34
1.3
1.4
—
—
—
0
0
6
44
1.37
0.34
9.0
3.8
—
—
—
0
0
557
5724
0.96
0.34
1.8
1.9
1.42
1.39
mmol/l
0.36
459
5045
47
415
1.14
0.34
4.8
2.8
—
—
—
0
0
6
45
1.33
0.33
1.0
1.0
—
—
—
0
0
6
45
1.33
0.33
1.2
1.1
—
—
—
0
0
6
46
1.31
0.33
3.3
1.8
—
—
—
0
0
11
142
0.77
0.30
1.1
1.1
—
—
—
0
0
7
54
1.30
0.30
3.7
3.1
10.20
9.12
mmol/l
—
7
54
32
278
1.15
0.29
1.1
1.1
1.58
2.29
eliau/ml
0.52
13
141
19
157
1.21
0.29
1.7
1.8
—
—
—
0
0
440
4528
0.96
0.29
1.6
1.6
—
—
—
0
0
37
326
1.14
0.29
1.2
1.1
16.63
16.71
au/ml
—
8
94
18
216
0.83
0.28
1.3
1.6
—
—
—
0
0
8
67
1.20
0.26
1.1
1.1
836.54
162.60
iu/ml
—
8
67
6
82
0.73
0.24
1.0
1.3
158.73
163.17
pmol/l
—
6
82
187
1791
1.05
0.24
1.3
1.2
—
—
—
0
0
52
475
1.10
0.24
2.0
2.2
7.30
3.90
iu/l
0.94
21
206
0
11
0.00
0.21
0.0
1.9
—
159.64
—
0
11
0
11
0.00
0.21
0.0
2.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
36.91
—
0
11
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
8
102
0.78
0.21
1.3
1.2
—
—
—
0
0
11
89
1.24
0.21
1.2
1.5
17.40
38.28
%
—
5
54
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.3
—
1.18
—
0
9
136
1420
0.95
0.19
1.4
1.4
27.13
24.80
iu/l
0.37
124
1235
27
241
1.12
0.19
2.6
2.8
1.77
1.54
mmol/l
0.42
27
228
14
118
1.19
0.19
1.1
1.2
—
—
—
0
0
7
59
1.19
0.18
1.4
1.8
—
—
—
0
0
651
6417
1.02
0.18
2.8
2.7
—
—
estimate
—
0
0
5
67
0.75
0.17
78.2
36.7
7.22
7.31
ug/l
—
5
59
10
120
0.83
0.16
1.0
1.0
—
—
—
0
0
8
68
1.18
0.16
1.4
1.7
—
—
—
0
0
107
1024
1.05
0.16
1.2
1.2
—
—
—
0
0
6
78
0.77
0.15
1.8
2.7
1154.83
628.96
ml
—
6
52
40
431
0.93
0.15
1.2
1.5
58.47
116.14
pmol/l
1.24
40
424
236
2300
1.03
0.15
4.7
4.4
1.57
1.87
ug/l
0.83
206
2110
70
738
0.95
0.15
1.9
2.1
6.79
6.80
ug/l
0.00
60
670
15
132
1.14
0.13
1.2
1.7
67.56
52.89
%
—
9
89
20
180
1.11
0.13
1.7
1.6
21.67
26.19
ng/l
0.49
20
180
30
323
0.93
0.12
1.1
1.1
—
—
—
0
0
21
191
1.10
0.11
2.7
2.9
7.81
7.24
mmol/l
0.44
21
181
14
124
1.13
0.11
1.6
2.1
32.50
32.47
pg
0.02
14
124
1280
12750
1.02
0.11
4.3
4.3
5.67
5.75
mmol/l
1.78
1186
12063
280
2849
0.98
0.10
1.3
1.3
3.48
10.05
u/ml
4.26
105
1194
20
218
0.92
0.10
5.5
3.3
—
—
—
0
0
5
45
1.11
0.09
2.0
3.3
0.63
0.61
mmol/l
—
5
45
441
4359
1.02
0.09
2.4
2.1
—
—
—
0
0
93
901
1.03
0.09
3.8
2.1
—
—
—
0
0
16
145
1.10
0.09
1.2
2.0
20.13
19.91
nmol/l
0.05
16
137
5
48
1.04
0.09
5.0
3.5
17.00
17.34
%
—
5
48
96
989
0.97
0.09
2.2
2.2
13.22
12.52
nmol/l
0.33
88
921
11
97
1.13
0.09
1.3
1.5
5.55
6.03
mmol/l
0.84
11
72
6
57
1.05
0.08
1.2
1.2
—
—
—
0
0
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
6
72
0.83
0.07
1.3
1.5
80.67
173.51
mmol/24h
—
6
72
7
85
0.82
0.07
1.3
1.2
—
837.50
—
0
16
9
85
1.06
0.07
1.3
1.3
—
—
—
0
0
94
963
0.97
0.07
3.8
2.1
—
—
—
0
0
12
132
0.91
0.06
3.3
3.5
15.97
55.95
u/ml
1.85
12
132
12
109
1.10
0.06
3.1
6.3
7.04
7.16
mmol/l
0.04
12
90
17
158
1.08
0.06
1.1
1.1
15.31
17.50
u/ml
—
8
70
11
121
0.91
0.06
1.1
1.2
—
—
—
0
0
17
159
1.07
0.05
1.1
1.1
—
—
—
0
0
37
382
0.97
0.04
1.5
1.4
322.97
306.65
ug/g
0.17
21
214
96
974
0.98
0.03
3.8
2.0
—
—
—
0
0
192
1934
0.99
0.02
1.7
1.9
—
—
—
0
0
96
970
0.99
0.02
3.7
2.1
—
—
—
0
0
77
777
0.99
0.01
4.2
2.1
—
—
—
0
0
10
94
1.06
0.01
1.7
1.4
75.00
72.36
umol/l
—
10
94
12
124
0.97
0.00
1.5
1.4
—
—
—
0
0
39
394
0.99
0.00
2.0
3.3
1.25
1.36
mg/l
0.54
31
363
40
402
0.99
0.00
1.2
1.2
—
—
—
0
0
96
962
1.00
0.00
3.4
2.0
—
—
—
0
0
12
123
0.98
0.00
1.0
1.2
—
—
—
0
0
25
253
0.99
0.00
2.8
3.0
6.70
7.78
pmol/l
0.37
25
253
26
257
1.01
0.00
1.2
1.1
1.14
2054.66
iu/ml
—
7
64
29
295
0.98
0.00
1.2
1.6
12117.35
9760.99
e6/l
0.16
23
219
322
3225
1.00
0.00
2.5
2.1
—
—
—
0
0
76
755
1.01
0.00
1.1
1.1
—
—
—
0
0
15
155
0.97
0.00
1.1
1.3
0.03
0.61
u/ml
—
7
76
6
69
0.87
0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
63
630
1.00
-0.00
1.7
1.6
7.72
10.86
u/ml
0.35
18
176
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
254.67
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
66
0.91
-0.00
2.3
2.6
53.83
49.91
umol/l
—
6
61
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.16
—
0
6
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
7597.20
—
0
5
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
30.86
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
30
300
1.00
-0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
215.56
—
0
9
0
6
0.00
-0.00
0.0
8.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.02
—
0
5
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
91
0.99
-0.00
2.8
2.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_OTHDEMYEL and mortality.

Females

Parameter HR [95% CI] p-value
G6_OTHDEMYEL 2.092 [1.77, 2.47] < 0.001
Birth year 0.994 [0.98, 1.0] 0.142

During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 4099 females with G6_OTHDEMYEL died.

Males

Parameter HR [95% CI] p-value
G6_OTHDEMYEL 2.444 [2.08, 2.87] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 2166 males with G6_OTHDEMYEL died.

Mortality risk

Mortality risk for people of age

years, who have G6_OTHDEMYEL.

N-year risk Females Males
1 0.224% 0.37%
5 1.238% 2.478%
10 2.828% 5.803%
15 5.52% 11.151%
20 9.909% 18.746%

Relationships between endpoints

Index endpoint: G6_OTHDEMYEL – Other demyelinating diseases of the central nervous system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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