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Other chondrocalcinosis

DOID EFO Endpoint Browser PheWeb

CHONDRO_OTH

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M11.2
  • Hospital discharge: ICD-9 — 7123
  • Cause of death: ICD-10 — M11.2
  • Cause of death: ICD-9 — 7123

2 out of 7 registries used, show all original rules.

532

4. Check minimum number of events

None

532

5. Include endpoints

None

532

6. Filter based on genotype QC (FinnGen only)

467

Control definitions (FinnGen only)

Control exclude
RHEUMA_CHRYSTAL

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M11
Name in latin
Aliae chondrocalcinoses

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2560 1394 1157
Only index persons 2391 1295 1096
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.03
Only index persons 0.04 0.05 0.04
Median age at first event (years)
Whole population 75.78 78.31 72.85
Only index persons 75.84 78.30 72.92

-FinnGen-

Key figures

All Female Male
Number of individuals 467 210 257
Unadjusted period prevalence (%) 0.10 0.07 0.12
Median age at first event (years) 74.49 74.07 74.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
479
Matched controls
4790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M11.2
ICD-10 Finland
Other chondrocalcinosis
4503599627370496.0
307.7
471
*
M13.9
ICD-10 Finland
Arthritis, unspecified
22.1
240.1
217
173
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
12.3
120.7
140
156
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.6
100.1
117
130
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
32.9
88.3
58
20
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
6.0
72.3
170
403
L04AX03
ATC
methotrexate; systemic
6.4
60.0
119
237
H02AB06
ATC
prednisolone; systemic
5.2
57.1
367
1848
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
5.3
52.5
129
310
P01BA02
ATC
hydroxychloroquine; oral
6.1
52.3
106
214
M10.9
ICD-10 Finland
Gout, unspecified
5.5
47.6
108
241
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.2
44.5
106
246
M25.5
ICD-10 Finland
Pain in joint
3.7
44.2
233
970
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
4.0
41.9
162
544
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.6
39.9
207
841
TNG10
NOMESCO Finland
Puncture of knee
14.0
36.0
34
26
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
5.3
32.2
71
152
A46
ICD-10 Finland
Erysipelas
3.4
29.8
142
533
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.3
26.2
119
431
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.4
26.1
114
403
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.0
25.4
83
241
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
7.9
25.4
36
49
M11.9
ICD-10 Finland
Crystal arthropathy, unspecified
+∞
25.2
24
*
R50.9
ICD-10 Finland
Fever, unspecified
3.2
25.1
123
465
A07EC01
ATC
sulfasalazine; oral, rectal
4.3
24.9
70
182
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
8.8
23.4
30
36
L15
ICPC
Knee symptom/complaint
2.7
23.2
174
827
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
3.9
22.7
74
214
NG1DA
NOMESCO Finland
X-ray of knees
7.8
21.9
31
42
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
3.7
21.8
76
230
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.8
21.6
141
620
L88
ICPC
Rheumatoid/seropositive arthritis
5.8
21.1
40
74
M11.8
ICD-10 Finland
Other specified crystal arthropathies
219.1
20.7
21
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
6.4
20.6
35
58
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
20.2
317
2091
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
5.7
19.8
38
71
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.9
19.5
108
433
M79.6
ICD-10 Finland
Pain in limb
2.4
19.3
258
1572
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.2
19.3
89
321
SPAT1263
SPAT
Sampling
2.4
19.2
249
1497
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
19.2
258
1576
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
19.0
96
365
L04AA13
ATC
[U] leflunomide
7.4
18.8
28
40
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
7.5
18.4
27
38
J01DB01
ATC
cefalexin; oral
3.4
18.3
423
3290
M35.3
ICD-10 Finland
Polymyalgia rheumatica
3.9
18.3
57
159
N02AJ06
ATC
codeine and paracetamol; systemic
2.3
18.3
244
1476
N02BE01
ATC
paracetamol; systemic, rectal
7.5
18.0
464
3854
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.3
17.9
74
249
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
5.8
17.7
33
60
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
17.6
227
1346
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
7.4
17.5
26
37
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.1
17.5
84
309
A02BC02
ATC
pantoprazole; systemic
2.6
16.8
376
2797
M01AH05
ATC
etoricoxib; oral
2.3
16.7
310
2123
NF1AA
NOMESCO Finland
Hip X-ray examination
2.9
16.4
88
344
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
7.1
16.3
25
37
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
7.5
15.8
23
32
N02AX02
ATC
tramadol; systemic, rectal
2.2
15.7
262
1703
S18
ICPC
Laceration/cut
2.2
15.6
284
1907
L11
ICPC
Wrist symptom/complaint
3.3
15.6
64
214
M01AH01
ATC
celecoxib; oral
2.5
15.4
123
587
B01AB05
ATC
enoxaparin; parenteral
2.2
15.4
207
1233
SPAT1153
SPAT
Removal of sutures
2.2
14.8
201
1196
B01AA03
ATC
warfarin; systemic
2.3
14.8
162
885
M10.0
ICD-10 Finland
Idiopathic gout
4.2
14.7
41
105
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
14.6
110
509
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
6.2
14.5
25
42
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.6
14.2
100
448
L90
ICPC
Osteoarthrosis of knee
3.2
14.1
61
210
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
14.0
191
1134
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.6
13.8
94
414
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.4
13.8
54
175
M04AA01
ATC
allopurinol; systemic
2.4
13.4
110
529
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
13.2
118
588
L28
ICPC
Limited function/disability (L)
2.2
13.2
146
796
N03AX16
ATC
[U] pregabalin
2.2
13.1
144
781
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
13.1
177
1041
M01AX05
ATC
glucosamine; oral
2.2
12.9
148
816
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.2
12.8
53
178
SPAT1254
SPAT
Administration of medicine
2.4
12.7
107
518
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
10.5
12.6
24
24
ND1AA
NOMESCO Finland
Wrist X-ray examination
3.2
12.6
54
185
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
4.1
12.6
36
94
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.4
12.4
32
77
M13.8
ICD-10 Finland
Other specified arthritis
14.8
12.4
20
14
R06.0
ICD-10 Finland
Dyspnoea
2.1
12.4
182
1101
M19.9
ICD-10 Finland
Arthrosis, unspecified
3.7
12.2
40
115
NK4AT
NOMESCO Finland
Puncture of joint with ultrasound guidance not elsewher classified
12.9
12.2
21
17
NG2AA
NOMESCO Finland
Patella X-ray examination
4.4
12.2
31
74
C03CA01
ATC
furosemide; systemic
2.0
12.2
238
1590
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
3.0
12.1
56
201
L20
ICPC
Joint symptom/complaint NOS
4.4
12.0
31
75
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.1
11.7
51
176
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.8
11.6
64
252
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
2.5
11.6
84
379
M13.0
ICD-10 Finland
Polyarthritis, unspecified
10.4
11.6
22
22
L08
ICPC
Shoulder symptom/complaint
2.1
11.5
136
754
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
11.5
217
1424
N03AX12
ATC
[U] gabapentin; oral
2.3
11.4
108
548
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
8.4
11.2
24
30
L17
ICPC
Foot/toe symptom/complaint
2.0
11.2
176
1082
R02
ICPC
Shortness of breath/dyspnoea
2.3
11.2
94
454
M48.0
ICD-10 Finland
Spinal stenosis
2.3
11.1
104
525
D64.9
ICD-10 Finland
Anaemia, unspecified
2.4
10.9
87
410
L01
ICPC
Neck symptom/complaint
2.4
10.8
86
405
ACC51
NOMESCO Finland
Release of median nerve
2.8
10.7
55
209
M19.2
ICD-10 Finland
Other secondary arthrosis
10.4
10.6
20
20
NH3EA
NOMESCO Finland
Feet X-ray examination with load
8.0
10.5
23
30
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
10.5
148
873
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
8.5
10.4
22
27
M10
ICD-10 Finland
Gout
3.3
10.4
40
128
R60.0
ICD-10 Finland
Localized oedema
2.2
10.4
97
488
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
10.4
170
1055
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
10.2
99
506
M09AX01
ATC
hyaluronic acid; parenteral
3.0
10.2
47
168
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
10.1
200
1317
L12
ICPC
Hand/finger symptom/complaint
2.2
10.1
96
486
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.9
10.0
172
1082
SPAT1249
SPAT
Treatment-related counselling outside office
1.9
10.0
200
1322
1220
FHL
Arthroscopy
3.7
9.9
32
91
SPAT1260
SPAT
Consultation of another employee
2.1
9.9
107
571
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.2
9.8
93
470
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.0
9.8
149
899
SPAT1202
SPAT
Intra-articular injection
3.9
9.7
29
78
SPAT1229
SPAT
Assessment of need for aid
2.6
9.5
61
259
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.8
9.4
29
80
J01CA04
ATC
amoxicillin; systemic
2.0
9.4
377
3083
JN3AD
NOMESCO Finland
Abdominal CT examination
2.2
9.4
84
415
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
7.5
9.3
21
29
M17.5
ICD-10 Finland
Other secondary gonarthrosis
8.6
9.1
19
23
M15
ICD-10 Finland
Polyarthrosis
2.9
9.1
44
161
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
3.8
9.1
28
77
A01
ICPC
Pain general/multiple sites
2.4
9.1
71
330
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
9.1
171
1101
S97
ICPC
Chronic ulcer skin
2.5
9.1
60
259
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.4
9.0
68
312
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
2.9
8.9
43
158
ND1AD
NOMESCO Finland
Wrist CT examination
11.0
8.8
16
15
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
9.7
8.8
17
18
H02AB07
ATC
prednisone; oral
2.2
8.8
86
439
K78
ICPC
Atrial fibrillation/flutter
2.3
8.8
71
335
N02AA05
ATC
oxycodone; systemic
1.9
8.6
135
817
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.5
8.6
58
253
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.0
8.4
38
134
M11.1
ICD-10 Finland
Familial chondrocalcinosis
+∞
8.4
8
*
A03
ICPC
Fever
2.2
8.4
75
370
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
8.3
171
1125
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
8.3
83
427
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.8
8.3
221
1570
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
4.9
8.2
18
38
SPAT1216
SPAT
Assessment of functional ability
2.0
8.2
109
624
NG1EA
NOMESCO Finland
Knee X-ray examination with wrench
6.5
8.1
20
32
A98
ICPC
Health maint/preventive medicine
2.9
8.1
449
4007
AA1AD
NOMESCO Finland
CT of head and brain
1.8
8.0
182
1232
M19.8
ICD-10 Finland
Other specified arthrosis
3.0
8.0
36
127
C07AB07
ATC
bisoprolol; oral
1.8
8.0
296
2299
JN4AD
NOMESCO Finland
Body CT examination
2.1
7.9
81
420
WZA00
NOMESCO Finland
Concise certificate
2.9
7.9
37
133
WX110
NOMESCO Finland
Infiltration anesthesia
1.8
7.9
318
2525
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
7.1
7.8
18
26
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.5
7.8
49
206
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
4.5
7.7
19
44
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
7.7
104
597
J01FF01
ATC
clindamycin; systemic
1.8
7.6
137
862
M25.4
ICD-10 Finland
Effusion of joint
7.3
7.5
17
24
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
4.0
7.5
21
54
M54.2
ICD-10 Finland
Cervicalgia
2.6
7.5
45
185
WX320
NOMESCO Finland
Spinalanesthesy
1.8
7.5
141
900
E0000UV, ,
ATC
1.7
7.4
201
1423
SPAT1255
SPAT
Intravenous administration of medicine
2.5
7.4
47
199
L04AB01
ATC
etanercept; parenteral
9.6
7.3
14
15
7123X
ICD-9 Finland
Crystal arthropathies, Chondrocalcinosis, unspecified
+∞
7.3
7
*
SPAT1310
SPAT
Counselling related to known health issue
1.7
7.2
165
1111
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
7.2
126
784
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
7.2
82
442
L01BA01
ATC
methotrexate; systemic
3.5
7.2
25
75
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.0
7.2
85
465
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.8
7.2
125
777
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.1
7.2
72
371
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
7.1
64
315
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
2.8
7.1
36
136
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.9
7.1
100
582
H25.8
ICD-10 Finland
Other senile cataract
2.0
7.0
88
491
SAA02
NOMESCO Finland
Basic examination of mouth
1.7
7.0
272
2105
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.8
7.0
124
774
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
3.4
6.9
25
77
M79.7
ICD-10 Finland
Fibromyalgia
4.2
6.9
18
44
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
6.8
63
314
J01CF05
ATC
flucloxacillin; systemic
2.5
6.8
45
194
L03
ICPC
Low back symptom/complaint
1.7
6.7
144
949
ZX120
NOMESCO Finland
Intravenous
2.2
6.7
60
295
S06
ICPC
Rash localized
2.6
6.7
38
152
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.1
6.7
18
45
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
8.0
6.7
14
18
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
3.1
6.7
28
95
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.4
6.6
24
74
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
12.5
6.6
11
9
M77.9
ICD-10 Finland
Enthesopathy, unspecified
3.9
6.6
19
50
B01AF02
ATC
apixaban; oral
1.9
6.6
97
571
M54.5
ICD-10 Finland
Low back pain
1.7
6.6
173
1206
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.8
6.5
20
55
SFA00
NOMESCO Finland
Small restoration
2.1
6.5
67
348
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
3.1
6.5
27
91
WZC00, ,
SPAT
2.0
6.5
74
400
SPAT1301
SPAT
No procedures
1.7
6.4
167
1160
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.6
6.4
21
61
M70.2
ICD-10 Finland
Olecranon bursitis
3.1
6.3
26
87
B81
ICPC
Anaemia vit B12/folate deficiency
2.8
6.3
31
115
D07AC01
ATC
betamethasone; topical
1.7
6.3
178
1261
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.2
6.3
25
82
ND1AE
NOMESCO Finland
Wrist ultrasound examination
18.3
6.3
9
5
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
6.3
59
296
M00.0
ICD-10 Finland
Staphylococcal arthritis and polyarthritis
+∞
6.3
6
*
A49.8
ICD-10 Finland
Other bacterial infections of unspecified site
7.2
6.3
14
20
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
3.2
6.3
24
77
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
6.2
147
992
S21
ICPC
Skin texture symptom/complaint
1.9
6.2
84
480
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
6.2
114
717
W22
ICD-10 Finland
Striking against or struck by other object(s)
2.7
6.2
32
122
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.0
6.1
27
94
M47.82
ICD-10 Finland
Other spondylosis, cervical region
2.8
6.1
30
111
N06AA09
ATC
amitriptyline; systemic
2.2
6.1
55
271
212
Kela drug reimbursment
Gout
3.7
6.1
19
53
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
3.0
6.1
26
89
WZA90
NOMESCO Finland
Other medical or dental certificate
1.8
6.0
111
698
Z01.2
ICD-10 Finland
Dental examination
1.6
6.0
189
1371
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
6.0
94
563
1221
FHL
Arthroscopy and meniscus surgery
3.1
6.0
24
79
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.1
6.0
24
79

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
255
133
39.86
307.65
2.1
1.3
—
—
—
0
0
202
125
27.22
254.40
2.5
1.5
32118.37
11559.47
e6/l
2.36
161
92
112
48
30.15
160.73
1.7
1.5
74.49
62.58
%
1.50
90
36
94
47
24.64
126.12
1.8
1.2
60949.64
258537.82
e6/l
0.62
67
33
88
39
27.42
123.78
2.0
1.3
19.54
32.10
%
1.34
73
28
259
709
6.78
98.09
2.6
2.0
—
—
—
0
0
236
628
6.44
91.02
1.7
1.3
22.04
14.73
u/ml
0.50
90
229
328
1180
6.65
89.90
4.1
3.0
337.26
360.89
umol/l
3.63
297
1008
231
686
5.57
76.47
1.6
1.3
25.39
37.69
iu/ml
1.24
92
218
222
851
4.00
48.51
3.2
2.5
11.27
12.23
umol/l
1.27
208
785
304
1461
3.96
47.07
6.4
4.7
—
—
—
0
0
167
534
4.27
46.93
1.5
1.3
390.59
463.41
titre
0.37
34
123
39
24
17.60
46.60
1.7
1.4
—
—
—
0
0
208
792
3.87
45.34
3.2
2.5
2.16
2.25
g/l
1.53
194
728
373
2165
4.27
41.38
10.4
5.8
0.04
0.04
e9/l
0.89
344
1845
194
743
3.71
41.25
3.4
2.5
21.82
21.85
%
0.01
183
685
371
2153
4.21
40.98
10.5
5.8
0.68
0.62
e9/l
4.11
342
1832
374
2184
4.25
40.90
10.8
5.9
1.76
1.90
e9/l
0.55
344
1917
377
2216
4.29
40.77
10.6
6.0
0.19
0.20
e9/l
0.13
346
1919
345
1992
3.62
36.43
9.9
6.0
61.44
58.62
%
4.34
336
1900
385
2396
4.09
35.90
12.8
9.5
4.88
4.30
e9/l
4.10
353
2090
344
1995
3.57
35.80
9.8
6.0
2.65
2.81
%
0.72
332
1868
344
1996
3.57
35.75
10.0
6.1
9.39
9.07
%
0.81
332
1871
345
2024
3.52
34.80
10.1
6.1
23.13
25.81
%
4.97
336
1917
341
1997
3.46
34.27
10.0
6.1
0.63
0.66
%
0.31
329
1869
373
2425
3.43
29.10
9.9
7.8
1.21
1.21
mmol/l
0.72
335
2082
350
2206
3.18
28.54
8.8
7.0
1.21
1.21
mmol/l
0.47
333
2017
71
173
4.64
27.50
1.8
1.6
5.53
9.06
iu/ml
0.60
20
48
128
472
3.34
27.45
2.5
2.8
64.78
66.30
g/l
1.44
120
432
440
3246
5.37
27.00
12.8
8.6
79.90
81.66
u/l
0.42
430
3053
263
1464
2.77
26.32
9.2
5.7
—
—
—
0
0
118
429
3.32
25.75
5.9
4.4
1.04
0.94
%
0.19
50
150
84
246
3.93
25.44
2.3
1.8
0.40
2.70
ug/l
1.26
76
217
48
90
5.82
25.01
1.0
1.1
—
—
—
0
0
112
403
3.32
24.78
6.0
4.5
0.07
0.13
%
0.53
43
125
236
1278
2.67
24.44
3.1
2.3
3.57
3.11
mg/l
1.99
209
1093
110
400
3.27
23.85
2.3
2.6
—
—
—
0
0
297
1825
2.65
23.35
4.3
3.0
176.95
150.10
ug/l
0.68
274
1654
112
417
3.20
23.31
6.6
4.7
0.05
0.19
%
0.81
41
118
33
16
22.05
22.89
1.6
1.0
40.52
35.06
g/l
—
23
8
109
408
3.16
22.41
6.0
4.3
0.61
0.54
%
0.17
41
135
401
2909
3.32
22.27
7.0
5.0
—
2.15
—
0
7
172
863
2.55
20.00
9.4
5.1
—
—
—
0
0
374
2679
2.81
19.91
6.2
5.7
6.69
6.86
mmol/l
1.00
361
2567
333
2262
2.55
19.68
6.3
4.4
0.00
6.81
estimate
0.80
92
514
101
388
3.03
19.67
4.6
3.8
92.43
87.40
ng/l
0.22
87
341
296
1914
2.43
19.39
3.0
2.5
80.54
78.89
nmol/l
0.46
272
1672
342
2361
2.57
19.37
31.7
18.4
1.49
1.33
inr
3.99
289
1992
330
2241
2.52
19.37
6.3
4.4
0.00
0.00
estimate
-0.00
92
492
124
543
2.73
18.88
1.9
1.8
—
—
—
0
0
276
1745
2.37
18.82
4.6
3.4
2165.45
1625.09
ng/l
1.39
244
1535
342
2379
2.53
18.75
6.8
6.8
10.56
12.03
umol/l
2.88
335
2261
280
1788
2.36
18.57
5.4
3.9
6.42
6.22
ph
1.97
150
991
332
2284
2.48
18.56
6.4
4.4
0.00
0.64
estimate
0.51
91
476
120
523
2.73
18.40
3.5
3.0
4.47
4.70
e9/l
0.19
104
450
66
203
3.61
18.40
3.4
4.3
36.45
74.00
mg/l
1.16
59
174
66
203
3.61
18.40
3.4
4.3
41.05
84.21
mg/l
0.82
59
173
55
152
3.96
17.87
1.4
1.2
2.79
1.93
u/ml
—
12
10
137
665
2.48
16.66
8.2
5.5
1.05
1.04
mmol/l
0.13
130
621
310
2124
2.30
16.65
5.8
5.2
33.07
34.78
g/l
5.41
291
1982
461
3860
6.17
16.51
39.3
20.1
31.69
26.66
mg/l
2.93
441
3302
135
661
2.45
16.04
3.2
2.7
1.85
1.80
%
0.22
119
596
43
110
4.20
15.47
2.0
2.3
13.42
13.42
mg/l
0.00
43
103
285
1927
2.18
15.26
6.3
4.5
50.23
58.92
ng/l
0.18
245
1547
236
1486
2.16
15.14
6.8
4.5
7.40
7.40
ph
0.40
188
1076
378
2879
2.48
15.01
7.5
5.4
150.00
2747.87
e6/l
—
9
62
43
113
4.08
14.93
1.3
1.2
1.47
3.01
u/ml
—
7
16
235
1484
2.15
14.89
2.8
2.2
150.61
242.49
u/l
1.05
227
1401
43
114
4.05
14.75
1.4
1.2
3.26
2.43
u/ml
0.47
12
19
248
1626
2.09
13.94
3.1
3.5
2.34
2.35
mmol/l
0.39
227
1460
153
837
2.22
13.76
3.2
3.3
0.80
0.82
mmol/l
1.00
147
791
191
1141
2.12
13.71
3.0
2.8
5.14
4.67
e6/l
0.22
181
1043
211
1310
2.09
13.66
6.8
4.5
0.00
0.00
estimate
0.50
85
453
67
253
2.92
13.21
1.7
2.0
1.63
1.54
g/l
0.26
62
231
108
521
2.39
12.99
3.4
2.8
72.57
68.75
e9/l
0.53
83
399
251
1688
2.02
12.79
6.5
4.5
0.00
0.03
estimate
1.47
82
424
283
1987
2.04
12.76
3.4
3.0
—
—
estimate
—
0
0
54
186
3.15
12.48
3.3
4.0
1.34
2.83
ratio
1.77
32
109
267
1854
1.99
12.22
22.3
12.9
0.00
0.00
e9/l
0.41
230
1537
164
965
2.06
11.93
2.2
1.8
1217.60
1184.50
nmol/l
0.16
125
724
460
4009
4.72
11.93
39.8
25.0
139.14
139.55
mmol/l
2.71
451
3936
460
4013
4.69
11.82
40.3
25.2
4.01
4.01
mmol/l
0.09
450
3934
376
2991
2.20
11.36
4.5
4.2
15.51
15.10
pmol/l
2.30
332
2657
459
4016
4.42
11.35
21.8
13.3
23.33
24.66
u/l
1.30
452
3876
216
1420
1.95
11.33
2.9
2.7
52.43
121.29
u/l
0.65
207
1318
47
159
3.17
11.18
1.2
1.2
—
—
—
0
0
226
1518
1.93
11.04
2.1
1.8
19.77
20.53
nmol/l
0.30
190
1251
57
219
2.82
10.85
1.1
1.4
—
41.50
—
0
22
249
1735
1.91
10.80
5.2
4.4
79.67
90.81
e6/l
0.13
205
1278
449
3902
3.41
10.65
30.7
18.1
—
—
—
0
0
462
4090
4.65
10.57
53.9
30.3
7.60
6.91
e9/l
5.42
455
3996
462
4090
4.65
10.57
53.7
30.2
4.24
4.40
e12/l
9.89
456
3996
462
4090
4.65
10.57
53.8
30.3
252.51
237.86
e9/l
4.16
455
4010
205
1352
1.90
10.42
4.1
3.6
0.45
0.47
e6/l
0.07
176
1019
231
1587
1.88
10.31
4.4
3.7
16.22
94.86
e6/l
1.26
201
1242
75
353
2.33
9.37
1.8
1.5
—
—
—
0
0
30
89
3.53
8.77
3.5
2.9
8.84
9.65
pmol/l
0.15
30
89
154
969
1.87
8.75
1.9
1.7
1.20
1.62
mg/l
1.78
124
782
14
10
14.37
8.74
1.4
1.0
—
—
—
0
0
418
3587
2.30
8.69
6.1
5.4
2.11
2.02
mu/l
0.72
380
3215
313
2447
1.81
8.47
3.9
3.4
62.96
57.28
u/l
0.52
290
2252
18
37
5.02
8.42
1.2
1.2
—
—
—
0
0
163
1055
1.83
8.40
2.1
1.8
437.53
13781362.08
pmol/l
0.80
135
849
218
1540
1.76
8.34
3.7
3.6
—
—
—
0
0
180
1207
1.79
8.21
5.2
3.9
0.31
0.07
estimate
0.34
81
394
280
2133
1.75
8.14
2.7
2.3
95.28
94.87
pmol/l
0.05
160
1118
78
395
2.16
8.14
5.7
4.3
1.21
1.22
mmol/l
0.49
72
344
83
436
2.09
7.87
1.9
1.6
—
—
—
0
0
49
207
2.52
7.73
1.6
2.4
9.79
10.56
g/l
0.63
44
184
36
130
2.91
7.67
1.3
1.7
—
—
—
0
0
77
397
2.12
7.66
1.8
1.5
—
—
—
0
0
425
3726
2.25
7.48
8.1
7.4
40.56
40.55
mmol/mol
0.01
391
3425
53
236
2.40
7.47
1.3
1.4
—
—
—
0
0
82
438
2.05
7.42
2.3
2.0
329.08
389.71
nmol/l
1.78
73
405
164
1097
1.75
7.39
2.8
2.5
—
—
—
0
0
48
207
2.47
7.25
2.9
2.3
0.00
0.02
estimate
0.49
17
57
10
5
20.38
7.16
2.0
1.2
—
—
—
0
0
149
978
1.76
7.13
3.6
3.2
491.69
538.36
mosm/kgh2o
2.33
137
864
84
460
2.00
7.08
6.7
4.2
7.38
7.35
ph
1.95
69
320
428
3782
2.24
7.07
6.2
5.8
5.96
6.13
mmol/l
2.15
392
3392
36
138
2.74
6.88
3.1
3.4
0.84
0.86
nmol/l
0.09
30
116
181
1269
1.69
6.76
8.7
6.3
—
—
—
0
0
41
170
2.54
6.72
2.6
3.1
216.68
288.17
mg/l
0.47
19
66
201
1468
1.64
6.30
3.0
2.6
—
—
—
0
0
118
749
1.76
6.24
1.6
1.5
2.79
2.70
g/l
0.19
82
444
223
1680
1.61
6.10
4.8
4.2
—
0.67
—
0
6
115
730
1.76
6.06
5.3
7.1
102.97
103.91
mmol/l
0.95
115
730
65
343
2.04
6.05
5.4
3.6
7.42
7.42
ph
0.47
58
289
124
809
1.72
5.92
1.3
1.2
0.64
1.49
u/ml
1.82
37
224
72
401
1.94
5.75
2.9
2.2
0.00
0.04
estimate
0.49
21
74
79
456
1.88
5.67
3.9
2.9
4.50
4.33
kpa
0.34
79
437
102
638
1.76
5.63
3.8
8.4
1.48
1.05
mmol/l
0.44
82
532
11
13
8.63
5.58
1.3
1.2
148.09
151.42
iu/ml
0.02
11
13
49
240
2.16
5.54
5.1
3.8
—
—
—
0
0
427
3847
2.01
5.47
6.6
6.4
2.35
2.51
mmol/l
3.29
390
3479
89
540
1.80
5.43
5.0
3.8
5.67
5.80
kpa
0.66
89
521
360
3097
1.65
5.30
39.9
25.2
14.43
13.93
%
7.74
355
3067
17
49
3.56
5.22
1.6
1.2
—
—
—
0
0
101
644
1.72
5.18
3.9
8.4
7.42
7.41
ph
0.01
60
391
88
544
1.76
5.03
4.9
3.8
7.39
7.38
ph
0.17
46
326
209
1602
1.54
5.02
2.2
2.3
—
—
—
0
0
18
56
3.30
4.94
4.2
4.1
—
—
—
0
0
146
1041
1.58
4.79
2.6
3.2
2.49
2.47
mmol/l
1.43
131
933
20
70
2.94
4.55
1.1
1.1
—
—
—
0
0
17
54
3.23
4.53
3.4
3.8
71.71
56.06
%
2.19
17
48
83
521
1.72
4.48
5.2
3.8
1.49
1.91
mmol/l
0.38
76
438
23
88
2.70
4.46
2.0
2.7
0.82
0.89
%
0.37
13
58
15
37
4.15
4.44
1.6
1.4
0.41
0.50
g/l
0.33
15
30
15
37
4.15
4.44
1.6
1.4
5.45
7.02
g/l
1.72
15
31
15
37
4.15
4.44
1.6
1.4
2.46
3.05
g/l
0.80
15
31
16
50
3.28
4.37
3.6
2.5
—
—
—
0
0
15
38
4.04
4.33
1.7
1.4
—
—
—
0
0
16
51
3.21
4.24
1.3
1.2
4.89
8.38
u/ml
—
9
21
398
3580
1.66
4.19
5.0
4.7
1.27
1.28
mmol/l
0.16
357
3194
411
3731
1.72
4.14
5.8
5.4
1.43
1.43
mmol/l
0.01
373
3357
18
63
2.93
4.10
1.3
1.4
167834.44
167498.90
e6/l
—
9
30
11
22
5.09
4.02
1.0
1.0
—
—
—
0
0
7
7
10.12
4.02
1.0
1.1
—
—
—
0
0
86
564
1.64
3.92
1.6
1.5
—
—
—
0
0
412
3756
1.69
3.91
6.0
5.6
4.23
4.41
mmol/l
2.86
373
3412
8
11
7.37
3.87
1.0
1.5
26.63
30.64
%
—
8
11
59
354
1.76
3.73
2.5
5.5
—
—
—
0
0
134
996
1.48
3.49
7.3
4.8
1.02
1.02
kg/l
0.19
99
699
199
1601
1.42
3.37
3.6
3.4
6.89
7.26
mmol/l
0.58
166
1327
57
352
1.70
3.27
5.7
4.0
—
—
—
0
0
10
24
4.23
3.21
1.0
1.6
43.69
38.63
%
—
10
24
36
195
1.91
3.16
1.8
1.3
—
—
—
0
0
36
196
1.90
3.12
2.2
3.3
4.16
4.35
pmol/l
0.52
30
169
18
74
2.49
3.08
1.3
1.4
755.67
1668.57
e6/l
1.18
12
51
23
106
2.23
3.08
8.7
3.8
2.66
2.83
mmol/l
0.07
16
69
199
1620
1.39
3.08
4.4
4.2
17.30
8.80
mg/mmol
1.05
134
1035
68
450
1.60
2.99
7.5
9.1
—
—
—
0
0
5
6
8.40
2.75
5.2
6.7
—
—
—
0
0
8
19
4.26
2.69
1.1
1.0
—
—
—
0
0
192
1582
1.36
2.66
3.6
3.5
78.57
51.15
mg/l
0.77
132
1051
21
100
2.15
2.62
1.5
1.6
—
—
—
0
0
11
37
3.02
2.50
2.7
2.1
—
—
—
0
0
15
63
2.43
2.48
1.4
2.8
0.74
0.99
g/24h
—
9
40
7
16
4.42
2.48
1.3
1.1
—
—
—
0
0
7
16
4.42
2.48
1.3
1.1
—
—
—
0
0
7
16
4.42
2.48
1.3
1.1
—
—
—
0
0
14
58
2.46
2.39
1.4
1.1
—
—
—
0
0
18
85
2.16
2.31
1.0
1.2
3.74
3.87
mmol/l
0.26
18
78
39
240
1.68
2.31
2.5
2.5
—
—
—
0
0
17
80
2.17
2.21
3.4
2.4
33.88
32.71
pg
0.83
17
80
22
115
1.96
2.19
1.3
1.4
48.41
57.74
mmol/l
1.07
17
97
34
205
1.71
2.17
1.2
1.3
—
—
—
0
0
7
19
3.72
2.16
1.7
1.2
132.86
178.14
mmol/24h
—
7
19
22
116
1.94
2.14
2.6
3.5
1.00
2.10
index
1.02
12
70
209
1786
1.30
2.13
5.7
6.0
2.94
2.84
ug/l
0.05
181
1579
11
43
2.59
2.09
1.3
3.2
9.15
7.80
mmol/l
0.36
11
43
11
43
2.59
2.09
1.1
1.0
—
—
—
0
0
5
10
5.04
2.07
1.2
1.5
0.00
0.00
estimate
—
5
10
7
20
3.54
2.06
1.1
1.9
36.93
40.86
g/l
—
7
20
6
15
4.04
2.04
1.2
1.0
—
—
—
0
0
21
112
1.92
1.99
6.8
3.2
—
—
—
0
0
14
64
2.22
1.96
1.4
1.4
—
—
—
0
0
14
64
2.22
1.96
1.1
1.1
—
—
—
0
0
6
16
3.78
1.94
2.0
4.9
58.17
45.50
%
—
6
16
29
174
1.71
1.91
1.3
1.1
45.82
129.30
u/ml
1.76
11
57
0
50
0.00
1.89
0.0
1.2
—
28.00
—
0
39
9
34
2.68
1.87
1.1
1.2
101.67
91.47
pmol/l
—
9
34
59
424
1.45
1.81
1.6
2.1
147.93
148.19
ug/g
0.00
41
339
13
60
2.20
1.79
1.1
1.0
—
—
—
0
0
14
67
2.12
1.77
1.3
1.5
—
—
—
0
0
14
67
2.12
1.77
1.3
1.5
—
—
—
0
0
14
67
2.12
1.77
1.3
1.5
—
—
—
0
0
14
67
2.12
1.77
1.3
1.5
—
—
—
0
0
16
81
2.01
1.76
1.3
1.2
—
—
—
0
0
62
453
1.42
1.75
3.2
2.6
3.56
6.52
ug/l
2.19
47
402
35
227
1.58
1.73
3.5
3.1
—
—
—
0
0
17
89
1.94
1.72
1.2
1.1
2.73
12.08
e6/l
0.60
11
65
7
25
2.83
1.65
1.1
1.3
28.00
28.62
%
—
7
20
13
63
2.09
1.61
5.1
2.2
—
—
—
0
0
8
32
2.52
1.60
1.4
1.8
64.13
82.00
ng/l
—
8
32
10
43
2.35
1.59
1.4
1.1
—
—
—
0
0
13
64
2.06
1.55
1.2
1.5
—
—
—
0
0
7
27
2.62
1.52
1.3
1.6
38.57
61.40
%
—
7
20
73
568
1.34
1.43
1.4
1.4
—
—
—
0
0
16
88
1.85
1.43
1.3
1.7
1.91
4.90
iu/l
—
5
31
8
164
0.48
1.38
1.0
1.5
—
—
—
0
0
55
415
1.37
1.32
2.5
2.5
25.88
36.90
u/l
2.11
40
338
23
145
1.62
1.31
1.4
1.4
0.13
0.30
mg/l
—
8
62
13
69
1.91
1.29
7.5
6.4
6.57
7.07
mmol/l
0.42
13
55
8
34
2.38
1.29
4.0
2.3
—
—
—
0
0
5
19
2.65
1.22
2.6
1.6
42.40
48.84
ug/l
—
5
19
66
520
1.31
1.21
2.2
3.1
7.91
8.34
umol/l
0.07
60
459
36
257
1.43
1.20
1.3
1.2
—
—
—
0
0
12
64
1.90
1.19
1.2
1.1
—
—
—
0
0
8
38
2.12
1.19
1.0
1.2
—
—
—
0
0
14
79
1.80
1.18
1.9
2.9
—
—
—
0
0
14
79
1.80
1.18
1.4
1.2
—
—
—
0
0
8
39
2.07
1.15
1.1
1.2
—
—
—
0
0
16
95
1.71
1.15
1.3
1.3
—
—
—
0
0
8
41
1.97
1.09
1.6
1.1
—
—
—
0
0
63
501
1.30
1.09
1.2
1.3
—
—
—
0
0
33
237
1.42
1.08
1.3
1.3
—
—
—
0
0
12
67
1.81
1.05
1.3
1.2
—
—
—
0
0
9
47
1.93
1.02
1.0
1.3
—
—
—
0
0
122
1057
1.21
1.00
3.2
3.5
0.77
0.82
ug/l
0.21
87
715
93
784
1.23
1.00
4.7
3.5
1.91
2.10
e6/l
0.11
44
404
121
1049
1.21
0.99
1.3
1.3
—
—
—
0
0
7
36
1.96
0.97
1.1
1.2
—
—
—
0
0
9
50
1.82
0.97
2.3
2.3
—
—
—
0
0
7
37
1.90
0.94
1.3
1.2
—
—
—
0
0
6
27
2.24
0.93
1.0
1.2
—
—
—
0
0
12
70
1.73
0.93
1.2
1.7
—
—
—
0
0
35
262
1.36
0.92
4.4
3.3
25.22
25.10
mmol/l
0.09
35
253
11
64
1.74
0.87
1.9
1.8
86.95
89.88
%
0.57
11
64
152
1360
1.17
0.86
2.6
3.2
34.28
34.21
u/l
0.01
141
1281
18
121
1.51
0.84
19.6
13.4
—
—
—
0
0
19
130
1.48
0.82
3.4
2.2
129.26
125.44
g/l
0.32
19
102
312
2962
1.15
0.77
6.0
4.9
—
0.11
—
0
9
72
611
1.21
0.75
1.3
1.3
—
—
—
0
0
28
212
1.34
0.72
2.2
2.0
—
—
—
0
0
7
41
1.72
0.70
1.6
1.2
—
—
—
0
0
65
552
1.21
0.68
2.7
4.4
3.73
28.82
ug/l
1.13
53
473
7
43
1.64
0.67
1.7
3.3
14.83
16.29
%
—
7
43
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
8
49
1.64
0.62
1.1
1.1
—
11.68
—
0
12
9
140
0.64
0.61
1.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
156.59
—
0
20
0
22
0.00
0.59
0.0
1.1
—
0.21
—
0
12
11
73
1.52
0.56
2.5
1.9
8.64
10.63
mmol/l
2.48
11
73
28
223
1.27
0.53
1.4
1.2
313.40
287.65
u/ml
0.06
28
209
16
121
1.33
0.44
1.3
1.2
—
—
—
0
0
7
51
1.38
0.44
16.4
2.5
452.29
1024.08
mg
—
7
51
41
351
1.18
0.43
4.1
3.0
6.12
6.06
ph
0.14
26
251
5
32
1.57
0.42
1.0
1.6
—
—
—
0
0
10
70
1.44
0.42
2.2
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
1.44
—
0
8
0
15
0.00
0.41
0.0
1.0
—
16.44
—
0
9
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
109343.70
—
0
10
29
242
1.21
0.40
5.1
3.9
1.02
1.02
ratio
0.69
24
227
9
66
1.37
0.38
1.2
1.2
1.38
1.54
g/l
—
9
66
5
36
1.39
0.38
1.6
1.2
—
—
—
0
0
170
1613
1.08
0.34
2.2
2.0
1.31
1.30
mmol/l
0.07
144
1302
35
403
0.86
0.34
1.5
1.4
—
—
—
0
0
11
143
0.76
0.32
1.8
1.9
3.27
3.47
mmol/l
—
6
106
7
52
1.35
0.31
1.0
1.3
0.23
0.19
nmol/l
—
7
36
42
373
1.14
0.30
1.4
1.5
—
—
—
0
0
18
148
1.22
0.29
5.4
3.2
1.90
1.67
mmol/l
0.40
18
143
8
110
0.72
0.29
1.1
1.1
—
—
—
0
0
9
73
1.24
0.25
1.2
1.2
0.84
0.90
g/l
—
9
73
0
11
0.00
0.21
0.0
1.0
—
54.27
—
0
11
0
11
0.00
0.21
0.0
13.7
—
1060.64
—
0
11
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
16.60
—
0
5
0
12
0.00
0.21
0.0
1.6
—
13.17
—
0
12
38
345
1.11
0.21
1.4
1.6
—
—
—
0
0
32
355
0.89
0.21
2.6
2.4
13.48
13.10
nmol/l
0.10
25
309
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
48
1.25
0.20
1.0
1.7
9.52
10.50
%
—
6
48
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
9
112
0.80
0.20
1.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.0
1.1
—
—
—
0
0
16
137
1.17
0.19
1.8
1.5
—
—
—
0
0
33
300
1.11
0.18
4.8
11.1
15.91
15.50
%
0.35
33
289
7
59
1.19
0.18
1.0
1.3
0.64
32.09
nmol/l
—
7
54
14
156
0.89
0.10
1.3
1.4
—
—
—
0
0
7
84
0.83
0.07
1.4
1.4
—
—
—
0
0
9
88
1.02
0.07
1.6
2.0
—
—
—
0
0
13
142
0.91
0.06
7.3
4.7
—
—
—
0
0
100
980
1.03
0.06
5.5
4.5
119.45
278.74
ng/l
1.30
87
860
124
1257
0.98
0.04
3.9
3.6
—
—
—
0
0
11
115
0.96
0.00
3.1
9.9
104.18
105.24
mmol/l
0.34
11
105
11
115
0.96
0.00
3.1
9.9
11.00
11.09
mmol/l
0.04
11
105
0
8
0.00
-0.00
0.0
7.3
—
0.65
—
0
8
0
9
0.00
-0.00
0.0
1.0
—
17.38
—
0
9
0
9
0.00
-0.00
0.0
5.1
—
6.90
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
42.57
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
8
83
0.96
-0.00
1.4
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.3
—
—
nmol/l
—
0
0
0
9
0.00
-0.00
0.0
10.2
—
4.71
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
1.50
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
45.41
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
70.57
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CHONDRO_OTH and mortality.

Females

Parameter HR [95% CI] p-value
CHONDRO_OTH 1.335 [1.09, 1.63] 0.004
Birth year 0.997 [0.99, 1.01] 0.533

During the follow-up period (1.1.1998 — 31.12.2019), 447 out of 1101 females with CHONDRO_OTH died.

Males

Parameter HR [95% CI] p-value
CHONDRO_OTH 1.598 [1.24, 2.05] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 335 out of 887 males with CHONDRO_OTH died.

Mortality risk

Mortality risk for people of age

years, who have CHONDRO_OTH.

N-year risk Females Males
1 0.165% 0.255%
5 0.921% 1.688%
10 2.104% 4.222%
15 4.053% 8.131%
20 7.215% 13.94%

Relationships between endpoints

↥

Index endpoint: CHONDRO_OTH – Other chondrocalcinosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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