No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
155 |
4. Check minimum number of eventsNone |
155 |
5. Include endpointsNone |
155 |
6. Filter based on genotype QC (FinnGen only) |
140 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_URINARY_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q6[0-4]
- Name in latin
- Aliae malformationes congenitae renis
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of kidney
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the urinary system
- Congenital malformations of the urinary system, including avohilmo
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly, including avohilmo
- All chronic kidney diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1596 | 808 | 785 |
| Only index persons | 1208 | 636 | 572 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 9.78 | 12.50 | 6.90 |
| Only index persons | 20.45 | 23.76 | 16.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 140 | 87 | 53 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 43.10 | 42.65 | 43.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 149
- Matched controls
- 1489
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q63.1
ICD-10 Finland
Lobulated, fused and horseshoe kidney
+∞
64.3
57
*
Q63.2
ICD-10 Finland
Ectopic kidney
+∞
45.1
41
*
Q63.9
ICD-10 Finland
Congenital malformation of kidney, unspecified
+∞
26.9
25
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
9.3
24.4
33
44
UKC02
NOMESCO Finland
Cystoscopy
6.8
23.1
44
86
Q63.88
ICD-10 Finland
Other specified congenital malformations of kidney
+∞
20.3
19
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
25.3
13.2
18
8
KA1FN
NOMESCO Finland
Isotope renography
70.6
11.8
13
*
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
+∞
11.6
11
*
Q63.0
ICD-10 Finland
Accessory kidney
+∞
10.5
10
*
N18.8
ICD-10 Finland
Other chronic renal failure
20.6
10.5
15
8
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
14.6
10.4
17
13
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
+∞
9.5
9
*
N18.0
ICD-10 Finland
End-stage renal disease
95.2
8.5
9
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
8.2
29
91
Z94.0
ICD-10 Finland
Kidney transplant status
23.5
8.1
11
5
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
23.5
8.1
11
5
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
14.1
8.0
13
10
N13.0
ICD-10 Finland
Hydronephrosis with ureteropelvic junction obstruction
47.5
7.8
9
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.6
7.7
19
32
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
26.6
7.7
10
*
TK800
NOMESCO Finland
Hemodialysis
14.4
7.5
12
9
KA1AE
NOMESCO Finland
Kidney ultrasound examination
11.7
7.5
13
12
Q63.81
ICD-10 Finland
Congenital diverticulum in renal cup
+∞
7.3
7
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
21.3
7.2
10
5
A11CC03
ATC
alfacalcidol; systemic
10.0
6.9
13
14
A12AA04
ATC
calcium carbonate; oral
11.7
6.9
12
11
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
42.0
6.8
8
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.7
6.8
49
232
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
23.8
6.8
9
*
KC1JB
NOMESCO Finland
Miktiocystography with X-ray
72.8
6.5
7
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
6.4
35
143
J01EA01
ATC
trimethoprim; systemic
2.6
6.4
47
224
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.2
6.3
28
101
Q62.5
ICD-10 Finland
Duplication of ureter
+∞
6.3
6
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
13.3
6.2
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
131
4.34
13.77
21.6
13.6
10.14
7.24
mmol/l
1.91
44
125
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
35
6.44
11.33
3.1
17.2
0.24
0.42
iu/ml
—
5
22
28
78
4.19
9.35
10.3
18.6
1.41
1.20
mg/l
0.72
28
72
97
655
2.38
5.90
19.3
10.3
1.21
1.22
mmol/l
0.33
90
582
69
411
2.26
5.56
9.7
3.5
0.24
0.38
e6/l
0.50
57
295
61
352
2.24
5.24
8.0
3.9
19.68
14.01
mg/mmol
0.36
44
214
14
27
5.60
5.23
8.8
5.3
8.81
10.63
pmol/l
0.22
14
27
46
244
2.28
4.78
7.6
3.6
1.51
2.75
e6/l
0.71
29
123
85
589
2.03
4.29
3.5
2.9
75.28
74.21
nmol/l
0.14
80
545
97
713
2.03
4.06
6.9
4.1
0.00
0.00
estimate
-0.00
26
126
96
705
2.01
4.00
6.8
4.1
0.00
12.30
estimate
0.50
27
132
95
698
1.99
3.92
6.9
4.0
0.00
0.00
estimate
-0.00
25
133
66
429
1.96
3.89
5.2
3.8
2.34
2.36
mmol/l
0.35
60
396
25
111
2.50
3.80
3.8
3.1
—
—
—
0
0
21
87
2.64
3.66
5.0
3.1
67.21
66.81
ml/min/173m2
0.02
14
36
44
264
1.94
3.18
6.7
3.4
0.97
0.81
e6/l
0.13
27
140
31
166
2.09
3.05
20.1
16.4
24.44
24.84
mmol/l
0.31
31
166
56
372
1.81
2.92
5.3
3.4
0.00
0.00
estimate
-0.00
22
104
5
6
8.56
2.77
1.0
1.2
—
—
—
0
0
5
6
8.56
2.77
1.6
1.0
8.86
11.00
umol/l
—
5
6
20
94
2.30
2.69
2.7
1.7
—
—
—
0
0
30
167
2.00
2.65
13.9
10.6
104.40
104.12
mmol/l
0.13
30
167
79
601
1.67
2.43
3.3
2.9
—
—
estimate
—
0
0
55
382
1.70
2.38
2.8
2.4
62.74
60.39
u/l
0.12
50
357
43
282
1.74
2.27
4.3
4.2
343.00
326.48
umol/l
0.68
38
252
47
319
1.69
2.19
2.6
2.8
—
—
—
0
0
25
140
1.94
2.17
15.7
11.8
1.11
1.15
mmol/l
0.03
13
110
16
75
2.27
2.17
7.6
8.2
0.84
0.64
%
1.91
16
75
6
14
4.41
2.17
1.0
1.6
—
—
—
0
0
11
43
2.68
2.13
1.4
1.6
—
—
—
0
0
21
113
2.00
2.04
1.5
1.3
133.44
397.34
u/ml
0.63
21
105
49
343
1.64
2.01
2.7
2.6
2.53
2.70
mg/l
0.36
43
300
5
11
4.66
1.95
1.2
1.1
96.00
92.36
%
—
5
11
23
130
1.91
1.95
12.3
9.8
5.04
5.24
kpa
0.58
23
123
23
131
1.89
1.91
12.3
9.8
0.49
1.19
mmol/l
0.27
18
110
25
147
1.84
1.88
11.9
10.2
23.96
23.77
mmol/l
0.14
25
147
63
476
1.56
1.86
2.5
1.9
91.99
98.79
pmol/l
0.48
32
241
21
118
1.91
1.81
6.3
3.3
0.04
0.20
e6/l
2.45
21
112
32
208
1.68
1.73
1.6
1.6
207407919.22
463.38
pmol/l
0.49
27
175
15
76
2.08
1.71
16.7
13.6
94.22
94.31
%
0.03
15
76
66
512
1.52
1.70
6.7
3.8
0.00
0.00
estimate
-0.00
18
107
131
1189
1.84
1.63
5.3
5.1
2.44
1.85
mu/l
0.38
121
1100
13
64
2.13
1.59
8.9
6.6
23.52
25.08
mmol/l
0.69
13
58
49
363
1.52
1.54
7.9
4.2
0.00
0.01
estimate
0.50
25
120
124
1115
1.66
1.51
25.8
13.4
77.68
87.81
ml/min/173m2
3.58
114
992
114
1006
1.56
1.50
4.5
4.3
14.91
14.56
pmol/l
0.83
105
930
9
41
2.27
1.39
1.2
1.8
—
—
—
0
0
13
68
2.00
1.38
1.9
1.2
—
—
—
0
0
0
40
0.00
1.35
0.0
1.7
—
—
—
0
0
9
43
2.16
1.33
1.1
1.4
—
13.45
—
0
8
40
295
1.49
1.26
2.3
3.2
1.16
1.13
mg/l
0.03
33
238
27
183
1.58
1.24
2.3
6.0
4.45
6.94
umol/l
0.72
22
159
41
305
1.47
1.24
1.7
1.7
23.17
21.95
nmol/l
0.14
34
257
8
38
2.17
1.20
1.1
2.7
—
—
—
0
0
7
31
2.32
1.12
1.1
1.9
—
—
—
0
0
9
50
1.85
0.98
3.4
1.3
—
—
—
0
0
125
1159
1.48
0.97
30.9
20.3
13.41
13.47
%
0.23
125
1148
51
412
1.36
0.96
3.5
3.5
31.06
29.92
ng/l
0.05
35
266
29
216
1.42
0.87
2.1
2.1
—
—
—
0
0
8
45
1.82
0.85
1.9
1.3
—
—
—
0
0
6
31
1.97
0.85
1.2
1.1
—
—
—
0
0
136
1292
1.60
0.82
28.7
15.3
26.60
22.41
mg/l
0.67
118
1031
6
32
1.91
0.82
1.2
1.9
—
—
—
0
0
90
803
1.30
0.81
9.5
13.1
3.65
3.89
e9/l
0.52
81
686
11
66
1.72
0.81
2.7
2.1
48836.20
7759.40
u/l
—
5
22
12
75
1.65
0.77
2.3
4.2
4.39
4.77
pmol/l
0.63
12
68
5
25
2.03
0.73
1.2
5.2
—
—
—
0
0
50
419
1.29
0.71
1.4
1.5
5.08
1.73
u/ml
0.34
18
86
7
118
0.57
0.71
2.0
2.2
—
—
—
0
0
22
162
1.42
0.71
2.0
2.0
—
—
—
0
0
7
41
1.74
0.71
1.0
1.3
—
—
—
0
0
7
41
1.74
0.71
4.1
2.3
—
—
—
0
0
11
69
1.64
0.70
10.5
9.0
15.33
15.84
%
0.19
11
64
5
28
1.81
0.66
1.2
1.5
—
—
—
0
0
5
29
1.75
0.64
1.0
1.1
—
—
—
0
0
16
114
1.45
0.61
2.3
4.6
4.29
6.10
ug/l
—
10
89
0
21
0.00
0.60
0.0
1.2
—
4.34
—
0
5
10
64
1.60
0.60
2.7
1.7
—
—
—
0
0
22
168
1.36
0.59
2.0
1.9
—
—
—
0
0
8
54
1.51
0.58
3.0
2.4
—
—
—
0
0
38
316
1.27
0.57
6.8
3.9
1.02
1.02
kg/l
0.33
31
205
9
133
0.66
0.55
2.2
2.4
—
—
—
0
0
14
100
1.44
0.54
8.9
8.4
—
—
—
0
0
59
521
1.22
0.52
2.1
2.0
1.23
1.41
mmol/l
0.69
49
450
11
77
1.46
0.47
1.9
1.3
—
—
—
0
0
6
91
0.64
0.44
2.0
1.6
2107.39
934.60
mu/l
—
6
78
8
58
1.40
0.42
1.9
1.2
—
—
—
0
0
5
33
1.53
0.41
1.6
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
5
34
1.49
0.40
1.6
1.3
—
—
—
0
0
25
207
1.25
0.40
1.7
1.5
—
—
—
0
0
102
965
1.18
0.37
4.4
4.7
12.07
10.22
mm/h
0.63
96
898
6
42
1.45
0.36
1.0
1.2
—
—
—
0
0
6
44
1.38
0.35
1.0
1.2
—
—
—
0
0
10
74
1.38
0.33
2.6
1.7
—
—
—
0
0
14
110
1.30
0.33
1.0
1.1
—
—
—
0
0
24
205
1.20
0.29
2.5
2.1
—
—
—
0
0
7
57
1.24
0.29
1.6
2.1
—
—
—
0
0
16
131
1.25
0.28
1.8
2.8
29.75
31.72
u/l
0.14
16
109
26
225
1.19
0.28
1.2
1.4
4.82
10.17
u/ml
0.54
13
85
18
150
1.23
0.28
3.3
2.9
0.73
0.71
ug/l
0.04
13
99
10
77
1.32
0.26
2.9
9.8
100.20
98.91
%
—
10
77
120
1163
1.16
0.25
4.9
4.3
5.58
5.79
mmol/l
1.51
114
1075
27
239
1.16
0.23
2.7
3.8
620.41
437.66
ng/l
0.11
17
170
5
41
1.23
0.22
1.4
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
4.3
—
242.18
—
0
11
0
11
0.00
0.21
0.0
1.7
—
7.90
—
0
11
0
11
0.00
0.21
0.0
1.1
—
252.85
—
0
11
0
10
0.00
0.21
0.0
5.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
51
1.18
0.19
1.0
1.3
0.14
2.59
u/ml
—
6
37
25
223
1.14
0.19
2.8
2.2
—
—
—
0
0
5
67
0.74
0.17
2.4
2.0
—
—
—
0
0
101
985
1.08
0.12
3.4
3.6
—
—
—
0
0
22
237
0.92
0.10
1.5
1.4
19.97
33.14
iu/ml
—
9
72
6
55
1.09
0.09
1.2
1.2
1.57
1.60
g/l
—
6
55
6
55
1.09
0.09
1.7
1.9
—
—
—
0
0
6
56
1.07
0.09
1.2
1.3
0.77
0.91
g/l
—
6
56
38
395
0.95
0.06
1.8
2.0
—
—
—
0
0
9
102
0.87
0.06
1.6
1.4
—
—
—
0
0
21
200
1.06
0.04
4.0
4.4
24.71
21.64
%
—
10
99
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
133.95
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
5.7
—
1.24
—
0
6
0
6
0.00
0.00
0.0
1.0
—
10.14
—
0
6
0
6
0.00
0.00
0.0
1.2
—
7.43
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
58.43
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
46.00
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
17.40
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
16.20
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
14.63
—
0
8
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
13.75
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_KIDNEY and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_KIDNEY | 1.732 [1.2, 2.49] | 0.003 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 696 males with Q17_OTHER_CONGEN_MALFO_KIDNEY died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_KIDNEY.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.409% |
| 5 | No data | 2.41% |
| 10 | No data | 5.811% |
| 15 | No data | 10.542% |
| 20 | No data | 17.333% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_KIDNEY – Other congenital malformations of kidney
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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