Pneumococcal septicemia

PNEUMO_SEPTHICHE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A40.3
  • Hospital discharge: ICD-9 0382
  • Hospital discharge: ICD-8 0382
  • Cause of death: ICD-10 A40.3
  • Cause of death: ICD-9 0382
  • Cause of death: ICD-8 0382

2 out of 7 registries used, show all original rules.

1518

4. Check minimum number of events

None

1518

5. Include endpoints

None

1518

6. Filter based on genotype QC (FinnGen only)

1290

Control definitions (FinnGen only)

Control exclude
ASTHMA_SEPTICHE_PNEUMONIA

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
A40
Name in latin
Septic(h)aemia pneumococcica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14540 6399 8046
Only index persons 12041 5409 6632
Unadjusted period prevalence (%)
Whole population 0.21 0.18 0.22
Only index persons 0.23 0.20 0.25
Median age at first event (years)
Whole population 40.52 39.46 41.06
Only index persons 36.59 36.71 36.49

-FinnGen-

Key figures

All Female Male
Number of individuals 1290 596 694
Unadjusted period prevalence (%) 0.27 0.21 0.32
Median age at first event (years) 59.64 55.60 63.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1352
Matched controls
13520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
+∞
307.7
1192
*
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
246.6
307.7
499
32
J18.9
ICD-10 Finland
Pneumonia, unspecified
8.2
307.7
886
2551
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
7.0
203.9
377
706
0382A
ICD-9 Finland
Septicaemia, Pneumococcal septicaemia
+∞
120.7
114
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.0
114.0
443
1479
A41.9
ICD-10 Finland
Sepsis, unspecified
7.6
104.4
157
229
J01MA14
ATC
moxifloxacin; systemic
4.9
100.8
253
603
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
86.3
856
4847
J86.9
ICD-10 Finland
Pyothorax without fistula
15.9
85.0
74
49
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.7
76.8
286
904
J01MA12
ATC
levofloxacin; systemic
3.1
69.2
384
1544
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
12.6
66.4
66
55
R50.9
ICD-10 Finland
Fever, unspecified
2.8
50.9
322
1365
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
4.3
50.0
136
339
R81
ICPC
Pneumonia
4.9
48.9
112
243
03820
ICD-8 Finland
Septicaemia, Pneumococcal
+∞
48.2
46
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
46.8
355
1641
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
44.5
239
923
C90.0
ICD-10 Finland
Multiple myeloma
10.1
43.8
50
51
WX872
NOMESCO Finland
Intensive care
4.1
43.3
128
339
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
42.3
271
1147
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.0
41.5
213
801
G00.1
ICD-10 Finland
Pneumococcal meningitis
419.9
41.4
41
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
41.3
389
1970
H02AB06
ATC
prednisolone; systemic
2.1
40.9
710
4598
R03BB04
ATC
tiotropium bromide; inhalant
2.9
39.5
208
792
WX892
NOMESCO Finland
Monitored bed care
3.2
37.5
166
572
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.2
36.5
103
263
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.8
36.4
117
328
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
11.5
36.3
38
34
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.3
34.7
327
1641
A41.8
ICD-10 Finland
Other specified sepsis
5.7
34.0
64
116
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.0
33.9
102
273
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
33.6
215
902
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
33.3
252
1146
C03CA01
ATC
furosemide; systemic
2.0
32.4
485
2905
J01FF01
ATC
clindamycin; systemic
2.1
30.5
408
2336
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
30.2
305
1565
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.9
29.2
754
5378
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.6
29.0
98
284
153
Kela drug reimbursment
Lenalidomid
11.3
28.5
30
27
S97
ICPC
Chronic ulcer skin
3.0
27.9
130
459
GD1AD
NOMESCO Finland
Thorax CT examination
3.0
27.7
129
456
TK800
NOMESCO Finland
Hemodialysis
5.3
27.3
56
110
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.9
27.1
61
130
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.3
26.8
106
340
L04AX04
ATC
lenalidomide; oral
10.6
26.3
29
28
A46
ICD-10 Finland
Erysipelas
2.2
25.6
243
1209
XW000
NOMESCO Finland
Bone marrow biopsy
3.6
25.5
89
263
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.8
24.5
77
212
ZX120
NOMESCO Finland
Intravenous
2.5
24.1
159
673
J45.1
ICD-10 Finland
Nonallergic asthma
2.7
23.8
132
512
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.2
23.7
99
328
R03AC02
ATC
salbutamol; inhalant
1.8
23.6
757
5621
ZXD05
NOMESCO Finland
Urgent procedure
1.9
23.6
435
2738
I50.9
ICD-10 Finland
Heart failure, unspecified
2.1
23.5
247
1276
R4110
NOMESCO Finland
Physiotherapy
1.9
22.7
404
2508
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
3.8
22.5
71
196
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.6
22.3
135
547
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
22.3
117
441
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.7
22.2
127
500
J01CA04
ATC
amoxicillin; systemic
2.0
21.2
1119
9509
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
50.9
21.2
25
5
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
21.0
248
1335
I50.0
ICD-10 Finland
Congestive heart failure
2.5
20.7
135
567
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.7
20.6
66
184
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
5.9
20.6
37
64
WX730
NOMESCO Finland
Conventional respirator
5.6
20.6
39
71
J96.1
ICD-10 Finland
Chronic respiratory failure
4.4
20.5
52
122
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.4
20.2
76
236
R03DA04
ATC
theophylline; systemic, rectal
2.9
19.9
95
340
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.3
19.7
165
775
JN4AD
NOMESCO Finland
Body CT examination
2.2
19.7
185
912
H02AB09
ATC
hydrocortisone; systemic
4.1
19.6
54
135
WW200
NOMESCO Finland
Immunization
3.9
19.5
57
149
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
4.5
18.8
46
105
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
6.2
18.6
32
53
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.8
18.6
94
347
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
18.5
286
1683
R95
ICPC
Chron obstructive pulmonary disease
3.6
18.4
62
179
J01DB01
ATC
cefalexin; oral
1.9
18.0
1101
9456
4810A
ICD-9 Finland
Pneumococcal pneumonia[PNEUMONIA PNEUMOCOCCICA]
33.4
18.0
23
7
R96
ICPC
Asthma
2.3
18.0
149
696
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.3
18.0
69
217
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.6
17.3
58
167
R02
ICPC
Shortness of breath/dyspnoea
2.0
17.2
209
1131
L04AA01
ATC
[U] ciclosporin
6.0
17.0
30
51
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
16.9
239
1362
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.5
16.8
115
493
WX882
NOMESCO Finland
High dependency care
3.2
16.6
67
217
A03
ICPC
Fever
1.9
16.6
262
1547
H02AB07
ATC
prednisone; oral
2.0
16.6
193
1028
TKC20
NOMESCO Finland
Catheterisation of bladder
2.4
16.3
115
500
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.2
16.1
65
211
AA1AD
NOMESCO Finland
CT of head and brain
1.7
15.9
403
2722
M04AA01
ATC
allopurinol; systemic
2.0
15.9
201
1102
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.0
15.8
73
256
H02AB04
ATC
methylprednisolone; systemic
2.0
15.8
194
1052
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.4
15.5
108
467
J15.4
ICD-10 Finland
Pneumonia due to other streptococci
161.8
15.5
16
*
A28
ICPC
Limited function/disability NOS
1.8
15.5
264
1594
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
15.5
423
2912
Z3231
NOMESCO Finland
Registered nurse
1.7
15.4
379
2538
120
Kela drug reimbursment
Hypogammaglobulinaemia
38.5
15.4
19
5
Z3226
NOMESCO Finland
Physiotherapist
1.8
15.3
256
1537
N17.8
ICD-10 Finland
Other acute renal failure
5.4
15.2
30
57
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
5.7
15.1
28
50
A02BC02
ATC
pantoprazole; systemic
1.6
15.0
865
7099
J46
ICD-10 Finland
Status asthmaticus
3.6
14.7
48
136
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
14.7
135
657
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
21.3
14.7
21
10
B18.2
ICD-10 Finland
Chronic viral hepatitis C
5.2
14.6
30
59
L03AA02
ATC
filgrastim; parenteral
3.4
14.6
53
161
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
14.6
379
2569
A07AA02
ATC
nystatin; oral
2.6
14.6
86
344
N02AX02
ATC
tramadol; systemic, rectal
1.6
14.5
548
4067
GBB00
NOMESCO Finland
Tracheostomy
5.5
14.5
28
52
Z72.0
ICD-10 Finland
Tobacco use
3.5
14.5
50
147
N05BA01
ATC
diazepam; systemic, rectal
2.0
14.4
177
959
WW500
NOMESCO Finland
Blood transfusion
2.8
14.4
72
264
L04AA06
ATC
mycophenolic acid; systemic
4.1
14.4
40
101
J45
ICD-10 Finland
Asthma
2.1
14.3
142
713
SPAT1255
SPAT
Intravenous administration of medicine
2.4
14.2
102
448
127
Kela drug reimbursment
Transplant complication
4.3
14.1
36
85
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
43.0
14.1
17
*
WX722
NOMESCO Finland
PEEP
2.7
14.1
79
308
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
13.9
194
1097
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
5.1
13.9
29
58
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
13.7
159
844
Z49.1
ICD-10 Finland
Extracorporeal dialysis
5.0
13.6
29
59
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
13.6
129
636
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.4
13.4
47
140
R05
ICPC
Cough
1.7
13.3
335
2243
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.7
13.3
70
264
R03AC12
ATC
salmeterol; inhalant
2.7
13.3
73
282
WX725
NOMESCO Finland
Noninvasive ventilation
2.4
13.2
90
385
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.2
13.2
123
601
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
3.0
12.9
57
195
C03DA01
ATC
spironolactone; oral
1.9
12.8
178
1004
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
12.8
188
1081
R03BA05
ATC
fluticasone; inhalant
1.7
12.7
244
1517
SPAT1262
SPAT
Handing over of treatment supplies
1.8
12.7
231
1415
SPAT1254
SPAT
Administration of medicine
1.8
12.6
220
1332
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
12.6
162
891
ZXE00
NOMESCO Finland
One hour or less
1.5
12.6
491
3642
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.7
12.5
39
107
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.2
12.5
103
479
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
5.1
12.4
26
52
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
2.5
12.4
76
310
J20
ICD-10 Finland
Acute bronchitis
2.0
12.3
141
744
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.1
12.3
123
618
C07AB07
ATC
bisoprolol; oral
1.5
12.2
620
4856
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
12.2
339
2323
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
3.9
12.1
35
91
Z2221
NOMESCO Finland
Medical doctor
1.6
12.1
346
2384
JN4BD
NOMESCO Finland
Extensive body CT
2.0
12.0
141
752
R06.0
ICD-10 Finland
Dyspnoea
1.6
11.9
366
2565
B03XA01
ATC
erythropoietin; parenteral
5.4
11.8
23
43
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
4.2
11.8
31
75
B01AB05
ATC
enoxaparin; parenteral
1.6
11.8
387
2753
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.7
11.7
253
1622
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.4
11.6
82
357
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
3.5
11.6
39
113
J96.0
ICD-10 Finland
Acute respiratory failure
4.2
11.6
30
72
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.6
11.5
296
1986
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.3
11.5
87
391
D65
ICD-10 Finland
Disseminated intravascular coagulation [defibrination syndrome]
35.3
11.3
14
*
TK810
NOMESCO Finland
Hemofiltration
9.0
11.3
23
26
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
11.2
477
3582
Z2446
NOMESCO Finland
Social worker
2.1
11.2
107
528
R06AE07
ATC
cetirizine; oral
1.5
11.2
528
4052
J01FA06
ATC
roxithromycin; oral
1.5
11.2
465
3476
B01AA03
ATC
warfarin; systemic
1.7
11.2
258
1683
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.3
11.1
41
126
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.5
11.0
68
278
J01CE02
ATC
phenoxymethylpenicillin; oral
1.5
10.9
852
7215
R03BA02
ATC
budesonide; inhalant
1.7
10.8
230
1468
N03AX16
ATC
[U] pregabalin
1.6
10.7
271
1809
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.6
10.5
316
2197
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
10.3
291
1990
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
3.3
10.3
38
117
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.6
10.3
58
227
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
10.2
81
372
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.7
10.1
52
194
A40.9
ICD-10 Finland
Streptococcal sepsis, unspecified
14.7
10.0
16
11
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
9.8
621
5006
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.1
9.8
93
458
SPAT1263
SPAT
Sampling
1.5
9.8
522
4074
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
9.8
529
4141
J47
ICD-10 Finland
Bronchiectasis
3.4
9.8
34
101
TGC00
NOMESCO Finland
Bronchial lavation
2.9
9.7
45
159
N02AA05
ATC
oxycodone; systemic
1.6
9.7
241
1598
J01AA02
ATC
doxycycline; systemic
1.5
9.7
932
8120
WX704
NOMESCO Finland
Intubation
2.0
9.6
110
581
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
8.4
9.6
20
24
A04AA01
ATC
ondansetron; systemic, rectal
2.0
9.6
110
582
J01DA01
ATC
[U] cefalexin
1.4
9.5
741
6191
6BA02, ,
NOMESCO Finland
15.1
9.5
15
10
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.2
9.5
80
376
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.9
9.5
122
670
JN3AD
NOMESCO Finland
Abdominal CT examination
1.7
9.4
167
1012
L04AD01
ATC
ciclosporin; systemic
3.4
9.3
33
99
B34.9
ICD-10 Finland
Viral infection, unspecified
2.7
9.3
50
191
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.2
9.3
76
353
A12AA04
ATC
calcium carbonate; oral
3.6
9.3
30
85
M10.9
ICD-10 Finland
Gout, unspecified
2.0
9.1
104
548
J12.1
ICD-10 Finland
Respiratory syncytial virus pneumonia
5.1
9.1
19
38
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
4.8
9.1
20
42
N03AG01
ATC
valproic acid; systemic, rectal
2.1
9.1
82
397
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.1
9.0
37
122
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.0
9.0
92
467
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.5
9.0
53
213
GAC97
NOMESCO Finland
Other endoscopic operation on pleura
18.7
8.9
13
7
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.0
8.9
93
475
N07BB01
ATC
disulfiram; oral
2.4
8.9
59
250
N18.0
ICD-10 Finland
End-stage renal disease
4.4
8.9
22
51
A40.0
ICD-10 Finland
Sepsis due to streptococcus, group A
12.6
8.9
15
12
R03DC03
ATC
montelukast; oral
1.6
8.8
196
1262
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
4.1
8.8
24
60
TQW11
NOMESCO Finland
Vacuum treatment of wound
3.0
8.8
37
124
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
8.7
427
3263
A10AB05
ATC
insulin aspart; parenteral
1.9
8.7
107
579
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
3.0
8.7
38
130
A02BC01
ATC
omeprazole; systemic
1.5
8.7
328
2384
E000001, ,
ATC
1.6
8.6
245
1672
N05AA02
ATC
levomepromazine; systemic
2.5
8.6
55
229
L04AX01
ATC
azathioprine; systemic
2.4
8.6
57
242
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.1
8.6
35
115
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
8.6
363
2697
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
2.8
8.5
41
148
J80
ICD-10 Finland
Adult respiratory distress syndrome
9.0
8.5
17
19
L01AA01
ATC
cyclophosphamide; systemic
10.1
8.5
16
16
N05CF01
ATC
zopiclone; oral
1.5
8.5
378
2833
A06AD11
ATC
lactulose; oral
1.6
8.5
190
1225
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.5
8.5
54
225
V03AE01
ATC
polystyrene sulfonate; oral
3.7
8.5
26
71
C01AA05
ATC
digoxin; systemic
1.9
8.5
111
614
M00.1
ICD-10 Finland
Pneumococcal arthritis and polyarthritis
90.6
8.4
9
*
ZX108
NOMESCO Finland
Inhalation
4.7
8.4
19
41
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
8.4
247
1701
J45.8
ICD-10 Finland
Mixed asthma
2.7
8.3
43
162
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
2.8
8.2
39
140
NE1AA
NOMESCO Finland
Pelvis X-ray examination
1.9
8.2
105
576
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
4.4
8.2
20
46
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
2.6
8.1
45
175
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
8.1
272
1924
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.3
8.1
61
274
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.8
8.1
123
712
A40.8
ICD-10 Finland
Other streptococcal sepsis
4.0
8.1
22
55
R03BA01
ATC
beclometasone; inhalant
1.7
8.1
160
999
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
6.3
8.0
20
32
UDC00
NOMESCO Finland
Ear microscopy
1.9
8.0
99
537
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
8.0
353
2638
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.3
7.9
59
264
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
4.5
7.9
19
43
WX213
NOMESCO Finland
Lower leg blockade
4.7
7.9
18
39
P15
ICPC
Chronic alcohol abuse
2.6
7.9
46
184
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.8
7.8
108
608
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
3.7
7.8
24
66
X59
ICD-10 Finland
Exposure to unspecified factor
1.5
7.8
244
1702
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
3.9
7.7
22
57
R11
ICD-10 Finland
Nausea and vomiting
1.8
7.7
118
685
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.7
1131
10401
NH1AD
NOMESCO Finland
Ankle and foot CT
3.0
7.7
33
112
M05BA04
ATC
alendronic acid; oral
1.9
7.7
100
552
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.4
7.7
51
217
I48.1
ICD-10 Finland
Persistent atrial fibrillation
2.2
7.6
61
282
ZX112
NOMESCO Finland
Subcutaneous
2.9
7.6
35
124
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
7.5
234
1627
B03XA02
ATC
darbepoetin alfa; parenteral
2.8
7.5
36
130
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
7.5
438
3437
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
3.1
7.5
31
103
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.6
7.5
41
159
DC1AD
NOMESCO Finland
Temporalbone CT
4.3
7.5
19
45
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
3.9
7.4
21
54
E0000UV, ,
ATC
1.4
7.4
510
4112
R03AC13
ATC
formoterol; inhalant
2.1
7.4
66
319
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
4.0
7.4
20
50
J02AC01
ATC
fluconazole; systemic
1.4
7.3
391
3019
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.5
7.3
298
2189
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
6.9
7.3
17
25
H02AB02
ATC
dexamethasone; systemic
1.7
7.3
134
820
137
Kela drug reimbursment
Uraemia requiring dialysis
4.2
7.3
19
46
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
3.9
7.3
21
55
J15.8
ICD-10 Finland
Other bacterial pneumonia
6.3
7.2
18
29
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
2.9
7.2
33
116
Z97.2
ICD-10 Finland
Presence of dental prosthetic device (complete)(partial)
2.4
7.2
46
192
207
Kela drug reimbursment
Chronic arrhythmias
1.6
7.2
199
1349
F10.20
ICD-10 Finland
Alcohol dependence currently independent
3.0
7.1
31
106
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
2.9
7.1
33
117
D07AA02
ATC
hydrocortisone; topical
1.6
7.1
182
1210
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
6.6
7.1
17
26
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.8
7.1
97
544
ZXE20
NOMESCO Finland
More than three and less than five hours
1.6
7.1
166
1081
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
3.8
7.1
21
56
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
4.1
7.1
19
47
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
7.0
112
658
R03AK03
ATC
[U] fenoterol and ipratropium bromide
2.0
7.0
70
353
J01MA02
ATC
ciprofloxacin; systemic
1.4
7.0
459
3665
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
2.8
7.0
34
124
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
7.0
393
3058
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
2.6
7.0
38
147
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
7.0
428
3380
J01CF05
ATC
flucloxacillin; systemic
1.8
6.9
97
548
Z94.0
ICD-10 Finland
Kidney transplant status
3.7
6.9
21
57
D09AB01
ATC
zinc bandage without supplements; topical
3.1
6.9
27
87
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
3.6
6.9
22
62
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
6.8
506
4116
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
8.3
6.8
14
17
48509
ICD-8 Finland
Bronchopneumonia, unspecified
3.8
6.8
20
53
103
Kela drug reimbursment
Diabetes, insulin-treated
1.4
6.8
330
2501
J85.1
ICD-10 Finland
Abscess of lung with pneumonia
16.8
6.7
10
6
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
16.8
6.7
10
6
M46.4
ICD-10 Finland
Discitis, unspecified
7.2
6.7
15
21
N18.8
ICD-10 Finland
Other chronic renal failure
2.7
6.7
34
127
S76
ICPC
Skin infection other
2.0
6.7
72
373
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
6.6
120
731
R10.0
ICD-10 Finland
Acute abdomen
2.5
6.6
40
163
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.2
6.6
51
232
A10AE04
ATC
insulin glargine; parenteral
1.7
6.6
124
764
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
2.5
6.6
39
158
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.1
6.5
62
307
329
Kela drug reimbursment
Lenalidomide
6.9
6.5
15
22
K65.0
ICD-10 Finland
Acute peritonitis
4.0
6.4
18
46
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
6.4
371
2893
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.0
6.4
64
323
J86.00
ICD-10 Finland
Empyema with broncho-pleural fistula
14.4
6.4
10
7
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
3.8
6.4
19
51
AA1AA
NOMESCO Finland
Head X-ray examination
3.8
6.4
19
51
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
6.4
118
724
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.6
6.4
151
987
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.3
6.3
45
198
I50
ICD-10 Finland
Heart failure
2.3
6.3
45
198
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
2.9
6.3
28
97
L04AD02
ATC
tacrolimus; systemic
3.6
6.3
20
56
D70.89
ICD-10 Finland
Neutropenic splenomegaly
3.5
6.3
21
61
GBB03
NOMESCO Finland
Percutaneous tracheostomy
+∞
6.3
6
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.0
6.2
26
87
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
26.8
6.2
8
*
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
26.8
6.2
8
*
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
2.9
6.2
28
98
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
7.1
6.2
14
20
WX110
NOMESCO Finland
Infiltration anesthesia
1.3
6.2
880
7848
R41.0
ICD-10 Finland
Disorientation, unspecified
2.3
6.2
45
200
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
5.1
6.2
18
36
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
4.0
6.2
17
43
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.2
6.2
52
246
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
2.2
6.2
50
233
TPX10
NOMESCO Finland
Implantation of vascular injection port
2.3
6.2
43
188
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
3.3
6.1
22
67
R03AC03
ATC
terbutaline; inhalant
1.6
6.1
152
1003
N05CD07
ATC
temazepam; oral
1.6
6.1
138
890
N05AB03
ATC
perphenazine; systemic, rectal
2.3
6.1
42
182
I95.9
ICD-10 Finland
Hypotension, unspecified
2.9
6.1
28
99
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
3.8
6.1
18
48
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
2.9
6.1
27
94
WX320
NOMESCO Finland
Spinalanesthesy
1.4
6.1
281
2108
7803A
ICD-9 Finland
General symptoms, Convulsions
3.6
6.0
19
53
R03BB01
ATC
ipratropium bromide; inhalant
2.1
6.0
53
255
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
10.1
6.0
11
11
L01AA03
ATC
melphalan; systemic
10.1
6.0
11
11
WX890
NOMESCO Finland
Intesive care monitoring
5.2
6.0
17
33

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
797
3440
4.21
148.23
7.2
4.4
—
—
—
0
0
301
962
3.74
79.76
5.6
2.9
11.78
10.74
g/l
1.88
281
892
93
109
9.09
73.84
1.4
1.2
—
—
—
0
0
714
4089
2.58
63.26
10.7
6.6
—
—
—
0
0
352
1418
3.00
62.53
12.6
8.9
7.41
7.42
ph
0.23
208
782
348
1430
2.93
59.30
12.7
8.8
5.11
5.13
kpa
0.09
330
1373
348
1431
2.93
59.21
12.7
8.8
10.26
12.26
kpa
15.71
330
1376
342
1410
2.91
57.76
12.5
8.8
1.19
0.92
mmol/l
0.45
289
1163
230
771
3.39
55.28
3.2
1.8
1.33
1.38
g/l
0.09
213
715
384
1763
2.65
52.01
2.7
2.1
—
—
—
0
0
374
1714
2.63
50.67
11.6
7.0
1.08
1.06
mmol/l
0.66
357
1598
302
1277
2.76
47.71
12.6
9.3
93.20
95.50
%
4.54
289
1238
838
5631
2.28
45.97
11.8
6.8
8.53
8.92
%
2.91
806
5301
849
5772
2.27
44.75
11.5
6.7
25.05
27.61
%
6.44
822
5504
832
5619
2.25
44.44
11.7
6.7
2.48
2.88
%
5.27
800
5286
829
5621
2.23
43.42
11.9
6.8
0.59
0.67
%
4.11
796
5286
275
1168
2.70
42.66
14.0
9.7
118.28
120.99
g/l
1.24
267
1141
70
112
6.54
42.22
2.5
2.9
1381.77
1253.70
e6/l
0.33
53
94
827
5682
2.17
40.80
11.3
6.6
59.94
57.28
%
5.95
808
5439
162
525
3.37
40.57
2.4
2.0
3.51
1.95
ug/l
1.12
147
468
267
1165
2.61
38.95
13.9
8.5
11.55
9.94
mmol/l
2.66
259
1119
879
6249
2.16
38.83
11.9
6.8
0.19
0.19
e9/l
0.10
773
5446
385
2018
2.27
37.17
6.6
4.0
0.81
0.82
mmol/l
0.70
364
1910
868
6199
2.12
37.09
11.4
6.6
2.15
1.92
e9/l
0.89
773
5453
430
2362
2.20
36.97
2.0
2.0
—
—
—
0
0
99
246
4.26
36.35
2.1
1.7
—
—
—
0
0
919
6734
2.14
36.31
17.3
9.8
4.76
4.12
e9/l
8.82
805
5838
849
6054
2.08
35.88
11.4
6.5
0.64
0.59
e9/l
7.61
736
5182
195
756
2.85
35.66
14.4
10.7
24.06
24.31
mmol/l
0.39
189
743
849
6066
2.07
35.53
11.4
6.5
0.04
0.04
e9/l
0.43
736
5198
851
6100
2.07
35.11
10.5
6.8
11.18
12.04
umol/l
1.05
824
5826
258
1165
2.50
34.72
12.9
8.7
1.64
1.36
mmol/l
1.32
252
1143
289
1380
2.39
34.37
7.7
4.9
7.38
7.38
ph
0.11
189
831
768
5334
2.02
34.25
15.3
7.4
1.20
1.21
mmol/l
3.89
723
4950
234
1015
2.58
34.24
6.3
2.9
66.69
66.40
g/l
0.15
208
936
302
1473
2.35
34.20
4.9
3.0
1.90
1.76
%
1.40
273
1332
349
1811
2.25
34.13
3.6
2.8
19.93
22.86
%
3.66
328
1695
81
181
4.70
33.99
1.8
1.6
—
—
—
0
0
81
181
4.70
33.99
1.8
1.6
—
—
—
0
0
81
181
4.70
33.99
1.8
1.6
—
—
—
0
0
81
181
4.70
33.99
1.8
1.6
—
—
—
0
0
285
1377
2.36
32.86
7.5
4.8
5.88
5.82
kpa
0.42
275
1340
365
1958
2.18
32.69
3.7
2.7
2.19
2.30
g/l
3.17
339
1813
80
184
4.56
32.39
3.8
3.9
2.13
1.38
%
0.49
75
169
54
87
6.42
32.31
2.4
3.1
683.09
599.17
e6/l
0.23
33
66
276
1329
2.35
32.00
7.5
4.9
1.70
1.77
mmol/l
0.09
244
1124
159
589
2.93
31.47
2.2
2.0
1.71
1.49
g/l
1.72
137
527
816
5914
1.96
30.75
16.6
7.9
1.20
1.21
mmol/l
4.42
727
5142
766
5437
1.94
30.70
19.3
16.0
1.32
1.28
inr
0.94
671
4559
176
699
2.75
30.54
15.3
12.0
15.06
15.81
%
2.66
168
671
191
794
2.64
30.28
6.5
2.6
—
—
—
0
0
249
1178
2.37
29.89
15.5
9.8
—
—
—
0
0
288
1463
2.23
29.16
2.7
1.7
—
—
—
0
0
371
2098
2.06
28.37
3.8
2.8
10.71
13.06
umol/l
9.11
347
1951
730
5182
1.89
28.36
9.9
5.6
33.07
35.57
g/l
19.82
691
4880
50
87
5.93
27.71
2.8
3.2
220.79
198.77
e6/l
0.17
34
71
238
1141
2.32
27.55
5.1
2.9
71.06
68.71
e9/l
0.41
176
846
58
118
5.09
27.16
1.5
1.3
2.33
2.86
g/l
1.11
38
87
58
118
5.09
27.16
1.5
1.3
0.40
0.43
g/l
0.21
38
87
58
118
5.09
27.16
1.4
1.3
—
—
—
0
0
58
118
5.09
27.16
1.5
1.3
10.05
6.62
g/l
1.69
35
87
116
402
3.06
25.72
8.0
3.5
174.88
38.09
mg/l
0.73
96
347
900
6956
1.88
25.47
11.0
5.6
6.94
6.69
mmol/l
2.21
864
6583
115
401
3.04
25.22
8.0
3.5
70.92
65.05
mg/l
0.13
95
344
204
949
2.35
25.18
9.8
4.6
5.11
5.14
kpa
0.18
194
915
70
178
4.09
24.88
3.8
2.9
—
—
—
0
0
53
108
5.07
24.77
2.4
2.8
36.73
37.33
%
0.09
53
108
58
129
4.65
24.46
1.5
1.3
—
—
—
0
0
235
1181
2.20
24.06
3.3
2.7
0.19
0.21
g/l
2.28
212
1099
106
363
3.08
23.97
7.9
3.3
4.57
3.73
ratio
0.16
67
208
198
929
2.33
23.90
9.9
4.7
7.42
7.41
ph
1.04
175
788
69
179
4.01
23.87
1.4
1.4
33.62
32.16
g/l
0.36
60
162
170
747
2.46
23.77
11.0
7.6
24.69
24.49
mmol/l
0.24
159
710
63
154
4.24
23.59
1.3
1.3
1403.72
1649.19
e6/l
0.24
40
106
119
444
2.84
23.09
5.9
2.5
2.81
2.97
g/l
0.88
104
405
123
471
2.77
22.72
6.2
2.5
7.49
7.30
g/l
0.58
108
432
123
471
2.77
22.72
6.2
2.5
4.17
3.65
g/l
0.80
108
432
123
471
2.77
22.72
6.2
2.5
4.17
4.15
g/l
0.07
108
432
522
3510
1.79
22.57
3.8
3.2
—
—
—
0
0
495
3278
1.80
22.52
2.9
2.4
3.12
2.84
mg/l
1.38
436
2819
71
199
3.71
22.03
2.0
1.8
0.60
0.83
g/l
1.02
53
161
508
3435
1.77
21.23
4.3
3.5
0.61
0.43
e6/l
0.91
380
2550
66
184
3.72
20.64
9.9
6.6
11.49
11.92
mg/l
0.33
60
168
941
7608
1.78
20.36
6.5
4.7
256.92
1703.05
e6/l
1.74
12
130
381
2395
1.82
20.18
3.6
3.1
503.21
549.63
mosm/kgh2o
4.22
342
2111
200
1009
2.15
20.06
5.7
4.6
0.91
0.65
%
0.49
113
322
101
372
2.85
20.04
3.3
1.4
0.23
0.24
g/l
0.30
94
354
125
514
2.58
20.02
8.8
6.1
0.76
0.87
%
2.64
117
483
555
3908
1.71
19.69
4.7
3.5
49.57
33.21
u/l
0.75
519
3703
563
3982
1.71
19.63
4.7
3.6
43.74
95.94
e6/l
1.44
435
3071
207
1067
2.11
19.62
5.8
4.7
0.78
0.93
%
0.50
119
345
507
3487
1.73
19.57
7.9
4.3
7.40
7.40
ph
0.16
395
2518
704
5300
1.68
19.31
18.6
11.9
0.00
0.00
e9/l
0.18
574
4318
53
133
4.11
19.18
1.3
1.3
111762.31
124798.71
e6/l
0.07
29
76
223
1194
2.04
19.05
6.5
4.3
4.73
4.59
kpa
0.42
213
1162
106
413
2.70
18.90
5.9
2.5
12.54
10.43
g/l
1.31
90
372
131
567
2.45
18.81
8.5
5.7
1.71
1.57
%
0.98
122
535
30
46
6.65
18.79
2.6
4.2
0.25
0.35
e9/l
—
10
20
1033
8672
1.81
18.64
14.1
8.3
89.96
80.79
u/l
4.72
997
8243
618
4528
1.67
18.55
5.4
4.2
47.27
117.68
e6/l
2.49
453
3214
386
2495
1.77
18.33
2.3
1.5
2.49
2.40
g/l
0.32
277
1527
74
240
3.20
18.33
9.1
9.3
11.95
11.37
mmol/l
0.72
65
216
74
240
3.20
18.33
9.1
9.3
104.08
105.19
mmol/l
0.81
65
216
86
305
2.94
18.28
3.0
3.4
35.27
34.54
umol/l
0.11
77
274
26
35
7.55
18.27
2.2
1.9
30.31
30.57
%
0.02
26
35
53
138
3.96
18.26
2.8
2.6
1.91
1.51
g/24h
0.22
34
84
319
1960
1.82
17.92
1.9
1.7
—
—
—
0
0
81
283
2.98
17.68
6.7
4.0
—
—
—
0
0
441
2993
1.70
17.42
8.3
4.5
83.56
87.59
%
2.97
427
2942
196
1035
2.05
17.30
6.3
5.1
0.01
0.12
%
1.88
102
277
244
1397
1.91
17.05
4.5
3.2
8.48
8.17
umol/l
0.09
205
1234
159
782
2.17
16.90
6.9
4.0
120.90
127.97
g/l
3.60
154
763
192
1017
2.03
16.78
6.0
4.8
0.10
0.12
%
0.21
102
294
510
3627
1.65
16.69
3.6
2.7
56.78
61.68
u/l
0.80
482
3369
45
111
4.16
16.68
4.1
2.2
—
—
—
0
0
252
1469
1.88
16.63
3.7
3.1
5.85
5.06
e9/l
0.34
218
1285
51
139
3.77
16.50
1.4
1.4
6.00
6.21
mmol/l
0.22
45
133
350
2265
1.74
16.26
6.1
4.0
334.22
465.65
ng/l
0.61
297
1757
50
136
3.78
16.22
1.3
1.4
—
—
—
0
0
247
1446
1.87
16.04
1.7
1.5
—
—
—
0
0
501
3576
1.64
16.00
4.5
3.4
2485.49
1508.75
ng/l
3.56
436
3096
49
133
3.79
15.95
4.1
4.1
—
—
—
0
0
88
347
2.64
15.32
9.3
7.8
1.33
1.34
mmol/l
0.04
77
299
174
924
2.01
15.04
5.1
3.1
328.57
219.96
ng/l
1.76
161
852
312
1999
1.73
14.85
2.1
1.8
1191.85
1181.42
nmol/l
0.06
242
1538
313
2019
1.72
14.50
3.7
3.3
3.66
1.82
e6/l
1.53
152
1023
301
1924
1.73
14.40
5.0
2.4
30.56
29.54
s
1.60
295
1872
491
3563
1.59
14.25
10.2
6.4
—
—
—
0
0
239
1440
1.80
14.00
1.9
1.6
—
—
—
0
0
324
2145
1.67
13.50
3.8
3.2
1.94
0.99
e6/l
1.63
167
1157
397
2767
1.62
13.49
3.9
2.8
7.76
5.36
e6/l
1.78
367
2526
173
954
1.93
13.36
1.4
1.5
—
—
—
0
0
68
253
2.78
13.27
7.0
4.7
2.83
2.71
mmol/l
0.11
46
166
77
306
2.61
13.21
3.6
2.4
123.23
129.46
g/l
1.58
62
246
34
81
4.28
13.21
3.3
3.1
43.18
39.38
%
0.46
17
37
52
167
3.20
13.13
3.7
2.8
—
—
—
0
0
45
133
3.47
12.96
1.3
1.6
—
—
—
0
0
132
674
2.06
12.66
11.6
4.9
—
—
—
0
0
697
5591
1.51
12.25
4.5
3.2
178.23
128.61
ug/l
2.60
645
5218
30
70
4.36
11.98
1.4
1.3
7.35
7.39
ph
0.42
19
51
96
442
2.26
11.96
1.3
1.2
—
—
—
0
0
148
805
1.94
11.87
1.7
1.3
186.27
250.98
u/ml
0.45
135
745
165
934
1.87
11.72
6.6
4.7
104.46
89.10
ng/l
0.96
144
825
55
196
2.88
11.64
1.7
1.9
—
—
—
0
0
66
259
2.63
11.64
4.4
2.9
15.24
16.16
%
1.71
66
253
100
477
2.18
11.43
3.3
1.7
12.25
7.72
iu/ml
0.44
31
105
42
132
3.25
11.02
4.6
2.4
0.58
0.50
mmol/l
0.04
42
127
61
239
2.63
10.80
1.4
1.6
55.98
66.62
mmol/l
1.28
47
204
29
72
4.09
10.71
2.3
1.6
—
—
—
0
0
243
1579
1.66
10.64
1.6
1.4
571.25
475.20
titre
0.34
64
333
25
56
4.53
10.51
2.3
1.8
—
—
—
0
0
193
1190
1.73
10.26
2.9
2.1
363.21
378.55
nmol/l
0.33
180
1110
74
328
2.33
10.09
1.3
1.1
—
—
—
0
0
559
4417
1.45
9.85
5.6
4.0
39.00
69.27
ng/l
1.24
428
3177
914
7951
1.46
9.40
6.5
4.6
—
3.63
—
0
12
72
331
2.24
9.04
1.2
1.3
95.00
86.87
titre
—
6
32
510
4009
1.44
9.03
5.3
3.5
2.33
2.35
mmol/l
2.41
468
3642
61
262
2.39
8.96
2.0
1.6
148.57
142.62
au/ml
0.09
14
79
32
97
3.35
8.93
1.3
1.2
18.56
13.15
u/l
0.95
27
88
180
1132
1.68
8.86
3.1
2.5
38.06
77.33
u/l
0.44
142
947
399
3005
1.47
8.83
5.0
3.0
372.15
350.77
umol/l
3.23
365
2650
518
4108
1.42
8.64
4.5
3.6
6.68
7.87
mmol/l
7.86
438
3524
1202
11153
1.70
8.59
36.7
16.6
41.35
25.16
mg/l
28.15
1111
9211
656
5431
1.40
8.51
4.3
2.9
—
—
estimate
—
0
0
440
3396
1.44
8.49
2.1
1.7
19.26
19.82
nmol/l
0.36
376
2897
60
263
2.34
8.43
4.3
3.2
57.96
57.92
%
0.01
60
263
19
41
4.69
8.36
1.6
1.3
—
—
—
0
0
37
128
2.94
8.32
1.9
1.7
64.79
61.32
%
0.19
24
85
350
2596
1.47
8.30
2.8
1.9
2.67
1.34
mg/l
2.63
291
1999
66
304
2.23
8.27
1.8
1.7
40183.35
13799.40
e6/l
1.47
49
220
62
281
2.26
8.08
2.0
1.5
—
—
—
0
0
48
198
2.48
7.72
3.0
2.0
1.54
1.62
mmol/l
0.30
48
192
89
475
1.94
7.57
4.9
3.0
21.46
21.09
s
0.32
81
435
47
197
2.44
7.32
4.3
3.4
4.83
4.28
e9/l
0.67
47
197
480
3840
1.39
7.30
4.1
2.6
—
—
—
0
0
616
5143
1.36
7.14
2.6
2.2
94.55
94.78
pmol/l
0.04
373
2776
43
176
2.49
7.05
1.2
1.1
1.56
1.50
g/l
0.59
38
158
66
325
2.08
7.03
4.7
3.4
4.49
1.90
index
0.45
37
181
44
185
2.42
6.83
3.5
1.9
0.91
0.88
%
0.14
36
133
46
198
2.37
6.78
1.1
1.1
—
—
—
0
0
461
3710
1.37
6.62
4.3
3.6
100.10
53.88
mg/l
1.82
327
2503
64
321
2.04
6.51
1.5
1.2
7.45
12.04
u/ml
0.32
20
45
171
1146
1.56
6.46
2.1
1.4
—
—
—
0
0
467
3780
1.36
6.42
5.2
4.3
17.74
9.33
mg/mmol
2.23
322
2474
61
305
2.05
6.27
1.1
1.2
—
—
—
0
0
719
6222
1.33
6.25
5.5
3.9
6.02
0.25
estimate
0.47
166
1256
338
2610
1.39
6.18
8.4
4.8
—
—
—
0
0
589
4970
1.33
6.02
5.0
3.5
6.35
6.24
ph
1.47
322
2758
17
44
3.90
5.99
5.1
3.7
—
—
—
0
0
707
6127
1.32
5.97
5.6
3.9
0.00
0.00
estimate
0.50
175
1324
64
333
1.97
5.91
1.5
1.2
26.65
14.45
u/ml
0.31
12
12
60
306
2.01
5.86
2.8
2.2
10.71
12.10
mg/l
0.67
55
282
62
320
1.98
5.86
1.5
1.2
2.31
2.34
u/ml
0.01
15
28
27
96
2.85
5.85
1.9
1.5
25.75
27.39
%
0.08
19
63
28
102
2.78
5.81
1.8
1.6
1.44
1.15
promille
0.43
23
85
440
3575
1.34
5.77
2.7
2.2
296.64
248.13
u/l
0.26
411
3395
18
50
3.64
5.77
1.5
1.4
1.00
1.43
%
—
5
7
712
6199
1.31
5.71
5.6
3.9
6.46
5.05
estimate
0.08
176
1339
1025
9405
1.37
5.71
41.1
20.5
14.16
13.62
%
22.97
1012
9296
99
601
1.70
5.58
1.4
1.2
—
—
—
0
0
845
7551
1.32
5.53
5.2
3.5
75.05
48.60
u/l
5.49
796
7121
81
467
1.78
5.47
2.8
2.5
8232.12
5245.61
u/l
0.26
31
199
601
5142
1.30
5.36
3.2
2.6
75.54
75.97
nmol/l
0.14
547
4645
74
421
1.80
5.23
12.4
7.7
1.60
1.51
mg/l
0.37
66
384
23
80
2.91
5.20
2.0
2.9
16.20
16.30
%
0.06
23
80
135
909
1.54
5.01
6.3
4.0
1.22
1.22
mmol/l
0.03
119
779
19
61
3.14
4.92
1.2
1.6
—
—
—
0
0
362
2920
1.33
4.85
4.0
2.5
—
—
—
0
0
19
62
3.09
4.80
2.8
2.7
1.89
1.89
umol/l
0.01
19
56
42
203
2.10
4.78
1.2
1.1
—
—
—
0
0
11
17
6.51
4.77
1.1
1.2
—
—
—
0
0
13
25
5.24
4.77
1.5
1.4
—
—
—
0
0
62
345
1.84
4.74
1.5
1.5
278.82
278.18
ug/g
0.01
34
209
397
3258
1.31
4.68
3.8
3.1
0.40
0.04
—
10
70
140
967
1.50
4.62
5.7
3.8
—
—
—
0
0
23
86
2.70
4.59
1.1
1.0
—
—
—
0
0
80
486
1.69
4.54
4.5
4.1
462.38
297.84
mg/l
0.78
47
231
303
2405
1.33
4.50
2.1
1.7
43478721.43
17557305.60
pmol/l
0.25
253
2022
13
27
4.85
4.50
1.1
1.2
—
—
—
0
0
340
4141
0.76
4.49
3.2
3.1
—
—
—
0
0
29
124
2.37
4.43
1.2
1.2
—
—
—
0
0
57
316
1.84
4.42
6.8
4.4
3.96
3.92
mmol/l
0.23
57
311
141
986
1.48
4.38
2.9
2.5
6.48
7.40
ug/l
0.33
115
882
29
125
2.35
4.36
1.0
1.1
—
—
—
0
0
31
138
2.28
4.33
1.1
1.2
—
—
—
0
0
12
24
5.03
4.32
1.6
1.8
—
—
—
0
0
31
139
2.26
4.27
1.3
1.1
—
—
—
0
0
22
84
2.65
4.24
1.8
2.6
7.74
8.10
mmol/l
0.18
22
84
55
308
1.82
4.15
4.2
3.1
1.64
1.55
mmol/l
0.32
50
302
47
252
1.90
4.06
2.4
3.4
0.86
0.85
nmol/l
0.10
39
206
15
47
3.22
4.06
1.8
2.2
895.00
959.10
e6/l
—
9
39
68
410
1.69
4.00
4.0
2.6
—
—
—
0
0
53
298
1.81
3.96
1.7
1.4
208.73
241.37
u/ml
0.44
30
154
79
498
1.62
3.92
1.5
1.4
—
—
—
0
0
70
430
1.66
3.85
1.5
1.2
0.45
1.50
u/ml
—
6
20
173
1291
1.39
3.79
1.8
1.8
—
—
—
0
0
12
29
4.17
3.70
8.2
7.2
5.90
5.23
kpa
0.37
12
29
15
50
3.02
3.69
3.0
1.8
—
—
—
0
0
14
40
3.53
3.61
3.0
1.8
40.61
40.14
g/l
0.08
14
40
58
939
0.60
3.61
1.2
1.3
—
—
—
0
0
30
143
2.12
3.60
1.6
1.4
—
—
—
0
0
29
139
2.11
3.45
1.6
1.2
—
—
—
0
0
19
76
2.52
3.38
1.1
1.0
—
—
—
0
0
76
1138
0.65
3.38
1.6
1.9
3.65
3.54
ratio
0.36
59
875
13
42
3.12
3.37
1.0
1.0
—
—
—
0
0
30
150
2.02
3.21
1.4
1.5
283.88
280.98
mosm/kgh2o
0.28
25
112
22
97
2.29
3.20
1.1
1.1
—
—
—
0
0
22
97
2.29
3.20
2.0
1.4
4.66
1.85
u/ml
0.44
14
54
27
132
2.07
3.08
1.5
1.9
—
—
—
0
0
13
41
3.19
3.06
2.6
2.5
0.62
0.61
mmol/l
0.20
13
41
16
62
2.60
3.05
57.3
32.9
115.19
134.54
ug/l
0.44
16
54
79
531
1.52
3.04
2.3
1.7
0.27
0.30
mg/l
0.18
41
256
53
839
0.62
3.04
1.4
1.7
3.21
3.43
mmol/l
0.88
36
589
1177
11296
1.32
3.02
41.5
19.9
3.97
3.98
mmol/l
0.53
1158
11050
12
36
3.35
3.02
2.1
1.9
—
—
—
0
0
1176
11286
1.32
3.01
41.1
19.7
138.76
139.60
mmol/l
21.25
1161
11061
27
134
2.04
2.97
1.0
1.1
—
—
—
0
0
391
3358
1.23
2.96
5.2
3.4
0.01
0.05
estimate
0.57
143
1048
70
463
1.54
2.91
3.2
3.5
90.03
3371.48
u/ml
0.89
55
398
280
2326
1.26
2.86
3.7
3.0
2.48
2.45
mmol/l
2.38
242
2088
44
261
1.71
2.82
3.9
2.4
—
—
—
0
0
11
33
3.35
2.81
1.0
1.1
—
—
—
0
0
70
468
1.52
2.78
3.1
2.0
—
—
—
0
0
73
493
1.51
2.77
1.4
1.2
—
—
—
0
0
42
249
1.71
2.71
1.4
1.2
58.67
47.41
u/ml
—
7
22
154
1192
1.33
2.71
3.8
4.3
13.94
23.20
ug/l
0.44
127
989
12
41
2.94
2.62
1.2
1.1
—
—
—
0
0
80
561
1.45
2.54
4.5
3.8
1.02
1.02
ratio
0.06
72
522
24
122
1.98
2.51
1.3
1.3
1.43
1.56
nmol/l
0.18
18
109
11
37
2.99
2.49
1.2
1.3
2.00
63.48
ug/l
—
5
16
41
248
1.67
2.48
1.4
1.9
—
—
—
0
0
9
26
3.48
2.48
2.1
2.3
1.67
2.88
%
—
9
26
7
16
4.39
2.47
1.0
1.8
—
—
—
0
0
8
21
3.83
2.46
1.4
1.5
—
—
—
0
0
1019
10648
0.83
2.36
5.1
4.9
1.38
1.43
mmol/l
2.88
952
9882
50
324
1.56
2.32
1.2
1.2
—
—
—
0
0
15
65
2.32
2.32
1.7
2.5
496.00
500.43
min
—
8
47
23
119
1.95
2.31
4.1
3.5
11.56
12.23
index
0.18
16
79
18
85
2.13
2.29
1.7
2.5
633.78
627.54
ml
—
9
56
6
13
4.63
2.27
1.3
1.0
—
—
—
0
0
30
171
1.77
2.26
1.2
1.2
6.12
5.00
u/ml
0.18
17
75
188
1533
1.26
2.25
1.4
1.3
—
—
—
0
0
8
24
3.35
2.18
2.4
3.4
14.40
15.83
ml/dl
—
8
19
8
24
3.35
2.18
1.0
1.0
—
—
—
0
0
16
74
2.18
2.15
2.3
1.8
10.80
20.22
umol/l
2.57
16
66
10
36
2.79
2.14
8.0
7.8
63.62
63.97
mg/mmol
—
10
31
123
959
1.31
2.10
1.6
1.4
—
—
—
0
0
80
590
1.38
1.98
2.9
2.2
0.00
1.35
estimate
0.50
22
186
5
11
4.56
1.94
1.4
1.0
—
—
—
0
0
5
11
4.56
1.94
1.4
1.0
—
—
—
0
0
75
550
1.38
1.92
2.9
2.0
—
—
—
0
0
1032
10717
0.84
1.90
5.2
5.0
4.41
4.52
mmol/l
2.67
972
10016
137
1101
1.27
1.87
2.7
2.1
0.00
0.02
estimate
0.78
25
233
388
3457
1.17
1.87
6.2
3.9
0.01
0.01
estimate
0.00
151
1223
27
159
1.71
1.86
2.1
1.6
23.59
32.18
ng/l
0.54
27
159
42
277
1.53
1.86
1.5
1.9
391.00
41.91
e6/l
1.11
31
207
509
4634
1.16
1.85
5.9
3.8
0.03
0.03
estimate
0.12
157
1106
21
115
1.84
1.83
1.5
1.3
33047.13
193325.11
e6/l
1.08
15
79
18
94
1.93
1.80
1.1
1.1
231.08
42.81
mg/l
0.71
13
77
8
29
2.77
1.79
2.4
1.9
—
—
—
0
0
57
404
1.43
1.79
1.6
1.7
24.73
10.74
u/ml
0.34
14
87
42
280
1.52
1.78
1.5
1.9
1574.19
562.96
e6/l
0.41
32
218
13
60
2.18
1.78
2.2
2.0
—
—
—
0
0
15
74
2.04
1.75
1.7
1.2
174.67
139.21
nmol/l
0.58
15
74
78
586
1.35
1.75
2.9
2.0
—
—
—
0
0
19
334
0.56
1.74
18.5
10.0
—
—
—
0
0
78
587
1.35
1.73
2.9
2.0
—
—
—
0
0
8
30
2.68
1.72
2.1
1.9
—
—
—
0
0
18
96
1.89
1.71
1.7
1.5
—
—
—
0
0
42
283
1.50
1.71
4.7
5.0
—
—
—
0
0
14
68
2.07
1.70
3.2
2.8
—
—
—
0
0
15
75
2.01
1.70
1.3
1.2
0.52
0.53
ratio
—
8
45
78
591
1.34
1.66
2.9
2.0
—
—
—
0
0
8
31
2.59
1.66
1.5
1.9
—
—
—
0
0
14
69
2.04
1.65
1.3
1.7
112.79
101.12
ng/l
0.09
14
69
11
49
2.26
1.63
1.1
1.1
384.93
182.57
iu/ml
0.36
11
49
471
4296
1.15
1.63
2.2
2.2
—
—
—
0
0
5
14
3.58
1.61
1.2
7.6
—
—
—
0
0
17
91
1.88
1.61
3.2
2.3
1.40
1.70
u/field
—
10
50
977
10151
0.86
1.60
4.5
4.2
1.35
1.28
mmol/l
2.41
906
9348
41
280
1.48
1.58
1.5
1.8
3.56
3.77
mmol/l
0.37
34
264
6
20
3.01
1.58
10.3
6.3
1.98
2.83
mg/l
—
6
15
11
50
2.21
1.57
1.6
1.2
136.64
506.48
u/l
0.99
11
44
1174
11429
1.21
1.56
29.8
14.8
—
—
—
0
0
22
130
1.70
1.53
1.4
2.4
—
—
—
0
0
125
1028
1.24
1.45
4.3
2.6
0.68
0.45
e6/l
0.61
120
980
27
172
1.58
1.43
4.4
3.2
7.22
9.37
umol/l
0.36
20
131
6
22
2.73
1.43
1.0
1.0
—
—
—
0
0
17
287
0.59
1.39
1.1
1.1
—
—
—
0
0
31
455
0.67
1.38
1.4
1.6
—
—
—
0
0
6
23
2.62
1.37
1.2
1.0
—
—
—
0
0
6
23
2.62
1.37
1.2
1.0
—
—
—
0
0
6
23
2.62
1.37
1.2
1.0
—
—
—
0
0
126
1048
1.22
1.33
8.2
4.4
7.39
7.35
ph
3.65
103
779
19
114
1.68
1.28
2.4
2.2
—
—
—
0
0
44
319
1.39
1.28
1.5
1.8
1097.92
498.27
mg/l
2.13
39
301
74
582
1.29
1.27
2.9
1.9
—
—
—
0
0
419
3849
1.13
1.26
4.6
3.7
—
0.81
—
0
16
381
3481
1.13
1.25
1.5
1.5
—
—
—
0
0
1199
11741
1.19
1.22
41.3
21.3
85.67
79.36
umol/l
3.42
1186
11606
5
19
2.64
1.21
1.8
6.5
8.62
8.22
mmol/l
—
5
19
5
19
2.64
1.21
4.0
4.2
—
—
—
0
0
52
393
1.34
1.19
1.2
1.3
171.32
235.29
miu/ml
0.52
16
185
15
86
1.75
1.19
1.1
1.1
—
—
—
0
0
62
482
1.30
1.17
2.6
2.7
—
—
—
0
0
171
1483
1.18
1.17
1.3
1.3
—
—
—
0
0
80
644
1.26
1.16
3.1
3.5
4.63
4.59
pmol/l
0.11
72
573
56
431
1.31
1.14
2.0
1.6
302.91
304.56
mu/l
0.01
45
396
7
30
2.34
1.12
1.1
1.4
5.99
8.05
mmol/l
—
7
30
811
7771
1.11
1.10
5.2
4.2
—
6313.94
—
0
16
5
21
2.39
1.09
3.0
1.4
—
—
—
0
0
14
81
1.74
1.09
1.1
1.0
—
—
—
0
0
1058
10852
0.88
1.08
5.8
5.6
2.54
2.64
mmol/l
3.34
985
10089
62
776
0.79
1.04
1.2
1.2
148.71
131.15
u/ml
0.10
21
293
5
22
2.28
1.03
2.2
3.8
—
—
—
0
0
14
83
1.69
1.01
1.4
1.3
—
—
—
0
0
227
2522
0.88
1.00
2.7
3.3
0.68
0.77
ug/l
1.05
149
1645
11
61
1.81
0.98
1.1
1.0
1474.64
1497.72
miu/ml
0.03
11
61
21
141
1.50
0.95
2.1
1.8
—
—
—
0
0
15
93
1.62
0.94
1.1
1.1
—
—
—
0
0
6
28
2.15
0.91
1.7
1.6
—
—
—
0
0
99
1161
0.84
0.91
2.8
2.3
11.62
13.09
nmol/l
1.21
84
1049
15
94
1.60
0.90
3.0
3.4
29.16
29.06
mg/l
—
9
71
6
29
2.07
0.89
2.5
2.0
18.27
16.30
umol/l
—
6
29
8
42
1.91
0.88
2.5
2.4
137.07
96.25
ug/l
—
8
42
26
357
0.72
0.87
1.1
1.1
1.43
1.50
g/l
0.94
26
357
69
569
1.22
0.86
1.7
1.6
948.44
965.28
mu/l
0.06
58
492
304
2803
1.11
0.85
1.4
1.4
3.32
1.55
u/ml
0.57
69
756
102
875
1.18
0.84
3.2
2.6
5.97
6.12
ph
1.02
74
603
22
155
1.43
0.81
1.1
1.2
—
—
—
0
0
66
547
1.22
0.79
2.8
2.4
—
—
—
0
0
32
417
0.76
0.78
2.2
1.8
34.47
40.74
nmol/l
1.49
32
398
14
90
1.56
0.78
1.2
1.1
97.14
106.49
pmol/l
0.29
14
90
5
97
0.51
0.78
2.2
5.2
—
37.84
—
0
31
58
477
1.23
0.76
1.6
1.5
22.40
21.35
iu/l
0.09
47
398
5
24
2.09
0.74
1.8
1.9
—
—
—
0
0
41
513
0.79
0.74
1.0
1.1
—
—
—
0
0
17
242
0.70
0.73
1.5
1.6
—
—
—
0
0
29
378
0.76
0.72
1.4
1.2
0.92
0.90
g/l
0.21
29
378
21
287
0.73
0.71
1.0
1.2
—
—
—
0
0
32
247
1.30
0.71
4.1
3.7
44.22
28.24
mg/l
1.16
27
181
50
410
1.23
0.69
1.6
1.6
10.29
7.93
u/l
0.74
39
325
5
27
1.85
0.68
1.4
3.4
3786.20
5.55
ug/l
—
5
27
11
69
1.60
0.68
3.7
2.6
20.27
28.83
umol/l
2.26
11
64
16
227
0.70
0.68
1.2
1.3
—
—
—
0
0
24
318
0.75
0.68
1.4
1.6
115.69
63.71
ug/l
0.39
19
278
23
170
1.36
0.67
1.2
1.5
0.42
0.31
nmol/l
0.22
17
136
17
237
0.71
0.66
1.5
1.5
—
—
—
0
0
5
28
1.79
0.66
1.0
1.5
54.80
96.82
nmol/24h
—
5
28
16
111
1.45
0.66
1.6
2.3
—
—
—
0
0
40
324
1.24
0.63
2.2
1.9
—
—
—
0
0
28
218
1.29
0.60
1.1
1.1
—
—
—
0
0
437
4581
0.93
0.59
2.0
2.0
1.39
1.34
mmol/l
0.53
381
3887
22
166
1.33
0.58
1.3
1.2
—
—
—
0
0
17
231
0.73
0.58
1.4
1.5
1.29
1.27
mm
—
9
173
203
1876
1.10
0.57
1.3
1.3
16.87
11.02
u/ml
0.36
55
718
1028
10462
0.93
0.56
5.5
5.0
6.11
5.94
mmol/l
2.78
941
9588
1177
11619
1.10
0.56
20.2
12.0
27.70
26.32
u/l
1.26
1150
11299
9
60
1.50
0.54
3.9
2.9
1604.44
2005.19
ml
—
9
53
142
1551
0.91
0.51
2.6
2.5
181.70
124.47
ug/g
1.03
109
1243
64
734
0.87
0.51
1.2
1.2
—
—
—
0
0
1003
10204
0.93
0.51
7.6
6.4
40.87
39.28
mmol/mol
4.83
939
9542
214
1998
1.08
0.50
1.4
1.3
45.80
30.81
iu/ml
0.69
73
604
7
45
1.56
0.49
1.7
2.9
—
—
—
0
0
21
163
1.29
0.48
1.0
1.2
—
—
—
0
0
7
46
1.52
0.48
1.1
1.1
—
—
—
0
0
27
219
1.24
0.45
1.1
1.1
—
—
—
0
0
17
220
0.77
0.45
1.4
1.7
—
—
—
0
0
7
50
1.40
0.45
1.4
1.6
0.37
0.51
e9/l
—
7
50
33
274
1.21
0.45
2.6
2.5
169.36
90.84
ug/min
0.57
22
165
5
32
1.56
0.42
1.2
1.3
25.80
27.13
s
—
5
32
8
57
1.41
0.42
1.3
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
1.98
—
0
16
0
17
0.00
0.40
0.0
1.0
—
0.22
—
0
5
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
8
61
1.31
0.39
1.3
1.2
—
—
—
0
0
1223
12133
1.08
0.36
49.8
25.0
7.87
6.81
e9/l
16.32
1204
11870
16
127
1.26
0.33
1.2
1.3
—
—
nmol/l
—
0
0
6
47
1.28
0.32
2.0
1.5
0.00
0.06
estimate
—
6
47
29
248
1.17
0.32
1.3
1.3
—
—
—
0
0
7
52
1.35
0.31
1.6
1.6
1.67
4.90
nmol/l
—
7
42
1039
10272
1.05
0.31
5.5
5.1
1.97
1.93
mu/l
0.38
955
9495
24
282
0.85
0.30
1.3
1.1
5.65
2.20
u/ml
0.53
18
163
127
1347
0.94
0.27
1.6
1.6
—
—
—
0
0
1220
12124
1.06
0.26
50.0
25.0
251.80
247.36
e9/l
1.21
1204
11892
21
246
0.85
0.26
1.0
1.1
0.72
1.26
u/ml
0.47
13
126
1220
12127
1.06
0.25
49.7
24.9
91.30
90.84
fl
2.48
1211
12000
103
968
1.07
0.24
1.1
1.2
—
—
—
0
0
16
133
1.21
0.24
1.8
2.6
—
—
—
0
0
949
9386
1.04
0.24
43.5
21.1
330.65
332.92
g/l
10.23
942
9323
1220
12130
1.06
0.24
49.8
24.9
4.29
4.50
e12/l
31.04
1202
11870
1220
12130
1.06
0.24
49.7
24.9
30.26
30.29
pg
0.21
1211
12001
1220
12130
1.06
0.24
51.5
25.6
38.45
40.35
%
26.05
1209
11994
5
40
1.25
0.22
1.8
3.2
—
—
—
0
0
1220
12134
1.06
0.22
50.4
25.2
128.28
135.36
g/l
40.59
1210
12004
26
294
0.88
0.21
1.9
2.0
4.07
4.14
iu/l
—
10
113
5
42
1.19
0.21
4.6
3.1
46.60
46.00
%
—
5
42
5
42
1.19
0.21
9.2
6.2
13.00
8.31
%
—
5
42
0
11
0.00
0.21
0.0
1.1
—
0.13
—
0
5
0
10
0.00
0.21
0.0
2.1
—
0.56
—
0
10
0
10
0.00
0.21
0.0
1.0
—
0.05
—
0
5
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
0.12
—
0
6
38
417
0.91
0.20
1.1
1.1
—
—
—
0
0
15
127
1.18
0.19
1.1
1.2
0.20
0.18
nmol/l
—
10
100
869
8607
1.03
0.17
4.5
4.2
14.74
14.83
pmol/l
0.47
791
7875
6
79
0.76
0.15
1.7
1.3
159.92
167.70
pmol/l
—
6
79
18
203
0.89
0.15
1.3
1.4
430.06
291.12
pmol/l
0.18
18
198
117
1216
0.96
0.15
1.5
1.7
—
—
—
0
0
5
47
1.06
0.09
1.0
1.1
—
—
—
0
0
6
56
1.07
0.08
1.7
1.4
5.83
6.19
mmol/l
—
6
56
6
57
1.05
0.08
1.2
1.0
—
—
—
0
0
10
88
1.14
0.08
1.4
1.2
—
—
—
0
0
6
74
0.81
0.07
3.3
1.5
88.67
82.19
umol/l
—
6
74
45
468
0.96
0.07
4.0
3.0
37.21
92.82
u/ml
1.23
45
450
18
167
1.08
0.07
1.2
1.2
—
—
—
0
0
24
252
0.95
0.05
1.0
1.1
4.00
7.52
u/ml
0.71
17
153
19
200
0.95
0.03
1.0
1.1
4.68
5.28
u/ml
0.05
12
111
129
1274
1.01
0.03
1.4
1.4
—
—
—
0
0
15
158
0.95
0.02
1.1
1.1
10.54
2.16
eliau/ml
—
5
65
421
4226
0.99
0.02
5.1
5.7
2.65
2.59
ug/l
0.04
372
3797
19
183
1.04
0.01
1.0
1.1
1.03
6.70
u/ml
—
10
93
279
2783
1.00
0.00
6.6
3.9
1.02
1.02
kg/l
0.45
210
1849
52
519
1.00
0.00
2.1
1.9
—
—
—
0
0
13
133
0.98
0.00
1.0
1.1
—
—
—
0
0
16
157
1.02
0.00
1.1
1.4
4.04
3.22
ug/l
0.49
11
139
10
105
0.95
0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
1.08
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
299.40
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
554.57
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
78.14
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint PNEUMO_SEPTHICHE and mortality.

Females

Parameter HR [95% CI] p-value
PNEUMO_SEPTHICHE 2.811 [2.33, 3.39] < 0.001
Birth year 0.992 [0.98, 1.0] 0.068

During the follow-up period (1.1.1998 — 31.12.2019), 996 out of 4840 females with PNEUMO_SEPTHICHE died.

Males

Parameter HR [95% CI] p-value
PNEUMO_SEPTHICHE 3.457 [2.88, 4.14] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1385 out of 5934 males with PNEUMO_SEPTHICHE died.

Mortality risk

Mortality risk for people of age

years, who have PNEUMO_SEPTHICHE.

N-year risk Females Males
1 0.271% 0.64%
5 1.424% 3.663%
10 3.592% 8.811%
15 7.108% 16.967%
20 12.402% 26.779%

Relationships between endpoints

Index endpoint: PNEUMO_SEPTHICHE – Pneumococcal septicemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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