Arteriovenous malformation of cerebral vessels

Q17_ARTERIOVENOUS_MALFORMATION_OF_CEREBRAL_VESSELS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q28.2
  • Cause of death: ICD-10 Q28.2

2 out of 7 registries used, show all original rules.

437

4. Check minimum number of events

None

437

5. Include endpoints

None

437

6. Filter based on genotype QC (FinnGen only)

392

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 392 209 183
Unadjusted period prevalence (%) 0.08 0.07 0.08
Median age at first event (years) 55.40 53.53 57.55

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
409
Matched controls
4090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q28.2
ICD-10 Finland
Arteriovenous malformation of cerebral vessels
+∞
307.7
409
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
102.4
214.3
112
15
Q28.3
ICD-10 Finland
Other malformations of cerebral vessels
611.0
100.0
95
*
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
164.8
98.1
100
8
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
12.5
88.2
97
99
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
25.9
83.4
60
27
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
8.0
73.6
122
207
AAC40
NOMESCO Finland
Extirpation of intracranial arterio-venous malformation
+∞
72.0
67
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
15.2
70.8
66
51
AA1AD
NOMESCO Finland
CT of head and brain
5.7
69.0
238
798
N03AF02
ATC
oxcarbazepine; oral
13.6
68.0
68
59
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
24.6
63.2
46
21
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
17.9
53.7
45
28
PA2JT
NOMESCO Finland
Very extensive embolisation of arterio-venous malformation of the brain
+∞
51.1
48
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
13.5
46.0
45
37
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
65.9
45.6
52
9
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
17.8
43.2
36
22
I60.8
ICD-10 Finland
Other subarachnoid haemorrhage
155.5
40.6
42
*
PA2HT
NOMESCO Finland
Extensive embolisation of arterio-venous malformation of the brain
+∞
39.2
37
*
N03AX14
ATC
levetiracetam; systemic
10.0
37.6
45
50
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.9
37.0
97
244
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.6
37.0
50
65
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
10.9
35.0
39
39
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
11.5
33.6
36
34
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.9
31.3
117
381
PA2GT
NOMESCO Finland
Embolisation of arterio-venous malformation of the brain
+∞
30.6
29
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
29.1
121
421
XA800
NOMESCO Finland
Neuropsychological investigation
6.0
27.4
52
97
N03AF01
ATC
carbamazepine; oral, rectal
5.6
26.7
55
111
H93.1
ICD-10 Finland
Tinnitus
4.6
25.8
68
169
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
59.9
24.3
28
5
H53.4
ICD-10 Finland
Visual field defects
8.6
24.2
32
40
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.5
23.7
49
99
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
53.1
21.4
25
5
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
16.7
19.6
31
20
R51.80
ICD-10 Finland
Headache
3.0
19.4
106
425
WX882
NOMESCO Finland
High dependency care
8.0
19.3
27
36
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
36.3
19.1
24
7
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
18.7
18.5
28
16
G40.10
ICD-10 Finland
Simple partial seizures
69.8
17.9
20
*
I61.8
ICD-10 Finland
Other intracerebral haemorrhage
+∞
17.8
17
*
XCK00
NOMESCO Finland
Perimetry
4.4
17.4
47
118
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
16.5
143
719
PA2AD
NOMESCO Finland
CT angiography of brain
19.5
16.2
24
13
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
20.2
15.7
23
12
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.9
15.5
35
76
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
22.0
14.8
21
10
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
155.3
14.6
15
*
K90
ICPC
Stroke/cerebrovascular accident
6.7
14.2
23
36
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
15.2
14.2
23
16
Q28.8
ICD-10 Finland
Other specified congenital malformations of circulatory system
144.6
13.5
14
*
Q28.0
ICD-10 Finland
Arteriovenous malformation of precerebral vessels
144.6
13.5
14
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
10.2
13.4
26
27
N03AG01
ATC
valproic acid; systemic, rectal
3.8
13.2
43
124
PA4AC
NOMESCO Finland
Vertebralis angiography with X-ray
51.7
12.9
15
*
I77.0
ICD-10 Finland
Arteriovenous fistula, acquired
72.2
12.7
14
*
XX4AW, ,
NOMESCO Finland
133.9
12.5
13
*
D18.0
ICD-10 Finland
Haemangioma, any site
6.1
12.4
22
38
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.2
12.2
53
184
AAF00
NOMESCO Finland
Ventriculostomy
27.7
12.1
16
6
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.8
11.8
27
59
PA5JT
NOMESCO Finland
Embolisation of very extensive arterio-venous malformation of carotis externa area
+∞
11.5
11
*
AAB30
NOMESCO Finland
Evacuation of spontaneous intracranial haematoma
+∞
11.5
11
*
R51
ICD-10 Finland
Headache
3.7
11.4
38
111
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
11.1
75
330
AA5PD
NOMESCO Finland
CT examination of brain pefusion
16.1
10.9
17
11
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
8.9
10.7
22
26
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
14.7
10.6
17
12
PA5AC
NOMESCO Finland
Angiography of arteries to the face with X-ray
+∞
10.5
10
*
Z2445
NOMESCO Finland
Psychologist
3.8
10.4
33
93
ZXD35
NOMESCO Finland
Usual procedure
4.5
10.2
25
58
H53.2
ICD-10 Finland
Diplopia
4.7
10.2
24
54
I61.4
ICD-10 Finland
Intracerebral haemorrhage in cerebellum
41.1
10.0
12
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
17.2
9.9
15
9
N03AX18
ATC
lacosamide; systemic
17.2
9.9
15
9
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.3
9.6
37
119
7478X
ICD-9 Finland
Other congenital anomalies of circulatory system, Other specified anomalies of circulatory system
+∞
9.4
9
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
9.1
82
408
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.9
8.8
43
159
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.6
8.8
29
84
Z3231
NOMESCO Finland
Registered nurse
2.0
8.6
125
744
ZXC95
NOMESCO Finland
Use of surgical navigator
9.7
8.3
16
17
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
10.3
8.1
15
15
183
Kela drug reimbursment
Lamotrigin and topiramate
10.3
8.1
15
15
R20.2
ICD-10 Finland
Paraesthesia of skin
2.8
8.1
42
161
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
22.5
8.1
11
5
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
22.5
8.1
11
5
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
7.9
158
1042
PA2CG
NOMESCO Finland
Extensive MRI examination of vessels in the head with high intensity magnet
45.9
7.7
9
*
AAC30
NOMESCO Finland
Intracranial occlusion of vascular fistula
81.5
7.4
8
*
AA9CW, ,
NOMESCO Finland
81.5
7.4
8
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
8.6
7.4
15
18
N18
ICPC
Paralysis/weakness
7.0
7.4
17
25
N03AB02
ATC
phenytoin; systemic
7.0
7.4
17
25
Q28.1
ICD-10 Finland
Other malformations of precerebral vessels
+∞
7.3
7
*
Q82.2
ICD-10 Finland
Mastocytosis
+∞
7.3
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
7.2
158
1064
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
20.4
7.2
10
5
WX002
NOMESCO Finland
Sedation and analgesia
2.0
7.0
88
495
WF099
NOMESCO Finland
Other radiotherapy
11.2
6.8
12
11
N88
ICPC
Epilepsy
12.5
6.6
11
9
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
10.3
6.6
12
12
H53.1
ICD-10 Finland
Subjective visual disturbances
2.6
6.6
38
154
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
5.9
6.5
17
30
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
4.0
6.5
18
46
G40
ICD-10 Finland
Epilepsy
7.6
6.5
14
19
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
70.9
6.4
7
*
WX892
NOMESCO Finland
Monitored bed care
2.5
6.4
40
169
G44.2
ICD-10 Finland
Tension-type headache
2.1
6.3
66
346
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
9.5
6.3
12
13
ZXD05
NOMESCO Finland
Urgent procedure
1.8
6.1
130
859
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.1
6.1
26
89
RS222, ,
NOMESCO Finland
8.8
6.1
12
14
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
6.0
67
360

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
179
865
2.90
24.01
2.4
2.4
—
—
—
0
0
216
1190
2.73
21.99
2.6
2.4
—
—
—
0
0
103
415
2.98
18.66
13.0
9.9
1.02
0.84
mmol/l
0.22
84
354
202
1142
2.52
18.60
2.4
2.1
137.91
233.93
u/l
1.02
195
1089
102
415
2.94
18.11
13.2
10.0
7.41
7.42
ph
0.23
63
241
260
1682
2.50
17.42
12.0
12.1
1.16
1.22
inr
1.13
220
1392
256
1689
2.38
15.75
3.0
2.9
—
—
estimate
—
0
0
167
920
2.38
15.62
5.8
4.0
93.30
90.40
%
0.93
161
909
240
1650
2.10
11.94
10.1
7.2
1.21
1.21
mmol/l
1.04
228
1535
290
2159
2.18
11.48
8.7
5.4
6.54
6.65
mmol/l
0.50
277
2055
254
1821
2.04
10.82
9.9
7.8
1.21
1.21
mmol/l
0.54
225
1586
19
18
11.01
10.38
3.5
3.4
28.08
35.87
umol/l
0.76
13
12
96
505
2.18
9.33
10.5
7.5
105.38
104.30
mmol/l
1.48
96
505
198
1424
1.76
7.19
3.9
3.7
32.89
34.99
ng/l
0.05
148
1012
149
998
1.78
6.85
5.9
4.4
—
—
—
0
0
65
332
2.14
6.69
15.7
9.7
—
—
—
0
0
103
627
1.86
6.43
3.9
3.6
0.83
0.82
mmol/l
0.36
96
604
16
42
3.92
5.59
2.0
1.1
—
—
—
0
0
24
90
2.77
4.84
1.9
1.2
—
—
—
0
0
142
1027
1.59
4.51
3.8
3.1
—
—
—
0
0
277
2339
1.57
4.32
5.4
4.6
—
392.02
—
0
41
55
318
1.84
3.97
3.8
3.6
4.75
4.56
kpa
0.30
55
310
62
379
1.75
3.72
3.6
4.1
5.79
5.70
kpa
0.36
62
370
42
227
1.95
3.71
2.7
3.5
24.45
24.18
mmol/l
0.32
42
227
117
842
1.55
3.69
1.9
1.6
1.07
1.22
mg/l
0.32
100
672
237
1977
1.47
3.59
7.3
6.9
11.10
11.64
umol/l
0.29
225
1886
38
203
1.96
3.48
2.8
3.2
0.62
0.61
%
0.11
38
203
49
290
1.78
3.29
1.8
2.4
6.45
7.20
ug/l
0.12
44
264
60
379
1.68
3.21
3.6
4.2
7.39
7.39
ph
0.01
31
217
137
1048
1.46
3.15
4.2
3.2
0.47
0.38
e6/l
0.18
105
759
385
3623
2.07
3.09
26.6
18.2
139.47
139.71
mmol/l
0.97
379
3568
6
8
7.59
3.06
1.7
1.6
18.12
16.71
umol/l
—
6
8
38
215
1.85
2.96
8.7
6.5
—
—
—
0
0
9
23
3.98
2.79
3.2
2.7
0.78
0.87
index
—
9
23
72
496
1.55
2.72
5.3
6.2
1.05
1.04
mmol/l
0.07
66
468
21
99
2.18
2.69
2.0
1.2
9.54
22.24
e6/l
0.52
13
72
80
566
1.51
2.67
2.3
2.1
—
—
—
0
0
21
100
2.16
2.63
2.0
1.2
623.14
142.90
e6/l
0.54
14
77
175
1441
1.37
2.54
2.4
2.1
—
—
—
0
0
383
3628
1.88
2.54
26.5
18.4
3.97
3.97
mmol/l
0.00
376
3566
192
1611
1.36
2.46
4.7
5.2
35.37
35.98
g/l
0.74
183
1530
41
252
1.70
2.45
5.6
4.1
7.41
7.42
ph
0.52
35
205
63
437
1.52
2.31
3.3
2.8
10.90
8.03
umol/l
0.37
52
386
54
362
1.57
2.30
2.4
2.6
36.23
44.31
u/l
0.26
47
303
280
2506
1.37
2.29
4.2
3.4
57.26
49.09
u/l
0.57
268
2381
222
1920
1.34
2.26
6.6
6.2
0.59
0.58
e9/l
0.13
195
1643
43
275
1.63
2.22
4.3
4.2
1.22
1.23
mmol/l
0.17
38
245
139
1123
1.36
2.22
4.4
4.2
7.39
7.40
ph
0.20
103
797
31
182
1.76
2.18
6.4
4.3
—
—
—
0
0
167
1391
1.34
2.17
4.7
3.9
74.76
97.86
e6/l
0.25
120
974
93
705
1.41
2.17
3.7
2.9
516.04
536.86
mosm/kgh2o
0.44
85
615
148
1216
1.34
2.10
4.2
3.3
23.55
50.28
e6/l
1.87
116
929
152
1255
1.34
2.08
6.4
6.3
—
—
—
0
0
5
10
5.05
2.07
1.4
1.0
—
—
—
0
0
185
1575
1.32
2.03
1.8
2.1
94.24
96.02
pmol/l
0.22
91
828
221
1929
1.32
2.03
6.7
6.3
0.04
0.04
e9/l
0.04
193
1649
11
44
2.54
2.02
1.9
2.8
4.07
4.07
mmol/l
0.03
11
44
11
44
2.54
2.02
1.9
2.8
105.00
105.30
mmol/l
0.12
11
44
11
44
2.54
2.02
1.9
2.8
1.20
1.19
mmol/l
0.08
11
44
373
3542
1.60
1.98
22.9
15.8
24.29
23.20
mg/l
0.26
332
2919
203
1763
1.30
1.89
7.1
6.2
3.03
2.83
%
0.55
192
1662
226
1991
1.30
1.89
6.9
6.6
0.19
0.19
e9/l
0.10
201
1736
223
1963
1.30
1.87
6.9
6.3
1.83
1.94
e9/l
0.77
196
1730
203
1766
1.30
1.85
7.1
6.4
8.88
8.88
%
0.00
193
1673
46
314
1.52
1.83
2.9
4.4
7.36
7.35
ph
0.09
39
231
12
53
2.30
1.82
2.3
1.3
—
—
—
0
0
90
699
1.37
1.81
3.2
3.7
558.54
360.93
ng/l
0.22
67
535
203
1772
1.29
1.78
6.9
6.2
56.58
57.30
%
0.39
193
1702
182
1570
1.29
1.74
4.1
3.4
6.27
6.20
ph
0.44
106
913
389
3749
1.77
1.73
14.4
12.2
25.54
26.56
u/l
0.70
380
3660
77
588
1.38
1.72
3.5
3.1
3.98
2.03
e6/l
0.50
40
290
108
873
1.32
1.67
4.6
3.6
—
0.50
—
0
6
200
1755
1.27
1.64
7.3
6.3
0.71
0.69
%
0.31
190
1655
66
495
1.40
1.64
1.2
1.2
—
—
—
0
0
141
1186
1.29
1.62
3.1
2.6
54.79
64.40
u/l
0.85
133
1110
126
1047
1.29
1.59
1.4
1.4
—
—
—
0
0
64
483
1.39
1.54
5.2
2.9
3.90
5.61
e9/l
1.23
55
421
103
837
1.31
1.53
3.4
2.7
4.69
4.95
e6/l
0.11
96
762
204
1806
1.26
1.52
7.0
6.3
27.43
27.65
%
0.11
194
1723
7
28
2.53
1.46
1.1
1.3
186.96
176.08
pmol/l
—
7
28
50
366
1.42
1.44
2.7
2.5
0.22
0.22
g/l
0.00
45
341
124
1056
1.25
1.25
3.3
2.9
—
0.11
—
0
19
10
49
2.07
1.23
1.0
1.2
—
—
—
0
0
44
326
1.39
1.20
1.6
1.7
—
—
—
0
0
298
2795
1.24
1.17
9.8
8.5
79.63
79.08
u/l
0.07
290
2655
24
159
1.54
1.15
2.5
1.9
—
—
—
0
0
14
80
1.78
1.14
5.7
5.1
—
—
—
0
0
217
1979
1.21
1.10
4.4
3.8
0.00
0.82
estimate
0.50
31
366
44
333
1.36
1.07
4.2
4.2
1.61
1.13
%
0.23
18
111
110
942
1.23
1.05
2.4
2.1
2.74
2.89
mg/l
0.35
91
813
7
34
2.08
1.03
1.7
1.6
—
—
—
0
0
5
110
0.45
1.01
1.2
2.3
7.78
11.39
mg/l
—
5
105
11
61
1.83
0.99
1.0
1.0
7.68
6.09
u/ml
—
5
34
0
29
0.00
0.98
0.0
3.9
—
8.58
—
0
29
7
36
1.96
0.97
2.1
1.9
—
—
—
0
0
350
3366
1.28
0.96
4.4
4.3
1.31
1.29
mmol/l
0.23
326
3128
30
405
0.72
0.95
1.7
1.7
—
—
—
0
0
41
314
1.34
0.94
4.5
4.2
0.83
0.63
%
0.14
15
97
214
1967
1.18
0.94
4.5
3.7
43.29
0.00
estimate
0.49
38
397
12
70
1.74
0.93
1.0
1.1
0.30
2.68
u/ml
—
6
39
142
1264
1.19
0.90
3.0
3.5
2.36
2.35
mmol/l
0.43
125
1155
180
1636
1.18
0.89
2.3
2.5
77.31
77.24
nmol/l
0.01
162
1485
43
335
1.32
0.89
2.3
3.0
72.62
72.17
e9/l
0.03
34
247
60
489
1.27
0.89
1.5
1.5
—
—
—
0
0
82
694
1.23
0.88
1.9
1.9
—
—
—
0
0
344
3310
1.25
0.88
5.5
5.2
1.83
1.89
mu/l
0.51
318
3070
229
2128
1.17
0.86
11.1
10.3
4.01
4.06
e9/l
0.14
202
1858
14
88
1.61
0.85
1.2
2.1
133.86
128.38
g/l
—
7
69
10
57
1.77
0.84
1.0
1.1
2.92
0.92
u/ml
—
5
24
35
268
1.33
0.82
2.3
2.5
41.83
14.26
au/ml
—
6
17
6
32
1.89
0.82
2.0
1.4
—
—
—
0
0
210
1946
1.16
0.79
4.5
3.7
0.00
0.00
estimate
0.50
36
392
135
1209
1.17
0.79
4.2
4.1
4.89
9.50
mg/mmol
1.84
75
752
0
26
0.00
0.78
0.0
1.1
—
394.05
—
0
20
119
1055
1.18
0.78
1.5
1.7
21.61
20.77
nmol/l
0.21
99
898
41
324
1.30
0.78
4.4
4.6
0.00
0.19
%
1.07
14
85
11
67
1.66
0.76
1.2
1.2
30.62
22.65
u/l
0.26
11
57
7
38
1.86
0.74
2.1
2.2
—
—
—
0
0
39
311
1.28
0.71
4.4
4.3
0.08
0.15
%
0.36
13
88
5
26
1.93
0.71
1.4
2.1
7.66
6.46
mmol/l
—
5
18
5
26
1.93
0.71
1.2
1.2
—
—
—
0
0
7
43
1.64
0.67
5.4
3.5
—
—
—
0
0
5
28
1.80
0.66
1.0
1.0
—
—
—
0
0
68
584
1.20
0.65
2.5
2.4
2.28
2.31
g/l
0.13
62
539
64
547
1.20
0.64
2.4
2.4
23.08
22.67
%
0.08
58
511
20
147
1.38
0.63
2.8
2.3
—
—
—
0
0
57
484
1.21
0.61
2.2
2.5
157.01
119.76
ug/g
0.38
47
391
5
30
1.67
0.61
1.0
1.0
20.60
52.72
mg/l
—
5
23
9
140
0.63
0.61
1.1
1.5
1.03
1.20
g/l
—
9
134
139
1272
1.14
0.60
3.4
3.3
8.73
7.88
mmol/l
1.13
119
1074
393
3871
1.39
0.59
33.6
23.8
252.81
249.41
e9/l
0.43
386
3810
83
732
1.17
0.59
1.7
1.8
462.22
46926005.13
pmol/l
1.19
73
618
0
23
0.00
0.58
0.0
1.9
—
—
—
0
0
12
172
0.69
0.57
1.6
1.8
—
—
—
0
0
32
257
1.27
0.57
1.4
1.2
—
—
—
0
0
130
1188
1.14
0.57
3.6
3.4
26.28
53.22
mg/l
2.36
77
772
6
36
1.68
0.57
1.2
1.1
—
—
—
0
0
393
3873
1.38
0.56
33.5
23.8
6.72
6.70
e9/l
0.08
386
3799
393
3873
1.38
0.56
33.5
23.8
4.47
4.52
e12/l
1.36
386
3802
6
38
1.59
0.54
2.8
3.3
7.85
11.48
%
—
6
38
57
491
1.19
0.54
1.3
1.3
—
—
—
0
0
18
134
1.36
0.54
1.1
1.4
—
—
—
0
0
137
1482
0.89
0.53
3.4
3.2
—
—
—
0
0
177
1657
1.12
0.52
15.3
11.3
0.00
0.00
e9/l
0.51
133
1343
10
67
1.50
0.50
10.5
2.8
—
—
—
0
0
18
136
1.34
0.50
1.1
1.4
—
—
—
0
0
7
107
0.65
0.49
2.1
1.9
187.57
229.08
pmol/l
—
7
100
25
199
1.27
0.49
1.3
1.3
—
—
—
0
0
18
137
1.33
0.48
1.1
1.4
—
—
—
0
0
67
754
0.87
0.47
3.4
3.0
0.66
0.72
ug/l
0.32
48
478
7
48
1.47
0.47
2.3
1.6
14.56
31.41
ng/l
—
7
48
7
48
1.47
0.47
1.0
1.3
—
—
—
0
0
17
129
1.33
0.46
1.1
1.4
—
—
—
0
0
33
394
0.82
0.46
1.3
1.5
—
—
—
0
0
5
81
0.61
0.46
1.0
1.4
—
—
—
0
0
15
112
1.35
0.45
1.9
1.5
346.50
266.34
ug/g
—
10
68
35
294
1.21
0.44
2.8
2.1
6.19
6.10
ph
0.24
24
189
66
587
1.15
0.44
1.5
1.6
—
—
—
0
0
186
1762
1.10
0.42
2.9
2.9
148.63
118.04
ug/l
0.70
176
1661
39
334
1.19
0.41
1.8
2.1
0.00
0.04
estimate
—
8
74
0
16
0.00
0.41
0.0
4.4
—
6.68
—
0
16
0
16
0.00
0.41
0.0
1.2
—
171.54
—
0
16
0
16
0.00
0.41
0.0
2.4
—
487.57
—
0
7
8
59
1.36
0.41
3.9
2.6
—
—
—
0
0
8
59
1.36
0.41
1.6
1.7
—
—
—
0
0
8
59
1.36
0.41
1.6
1.7
—
—
—
0
0
8
59
1.36
0.41
1.6
1.7
—
—
—
0
0
8
59
1.36
0.41
1.6
1.7
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
0.00
—
0
17
17
215
0.78
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
159
1499
1.10
0.39
4.6
3.6
0.03
0.02
estimate
0.07
32
326
5
36
1.39
0.38
1.0
1.1
—
0.08
—
0
6
8
113
0.70
0.37
1.3
1.4
—
—
—
0
0
69
624
1.13
0.37
2.6
2.4
12.65
13.18
umol/l
0.23
63
577
287
2788
1.10
0.36
4.7
4.2
14.80
14.74
pmol/l
0.15
266
2562
18
145
1.25
0.34
1.4
1.5
14.38
8.96
u/ml
—
5
30
14
109
1.29
0.34
1.4
1.3
—
—
—
0
0
90
833
1.10
0.33
1.5
1.5
2.36
2.44
g/l
0.11
58
516
17
138
1.24
0.31
1.1
1.4
—
—
—
0
0
49
440
1.13
0.30
2.0
1.7
—
—
—
0
0
96
899
1.09
0.28
1.4
1.3
1.28
1.73
u/ml
0.20
25
248
13
161
0.80
0.27
1.2
1.4
—
18.56
—
0
5
15
122
1.24
0.27
2.5
2.1
67.33
5348.92
u/l
—
6
43
31
272
1.15
0.27
3.4
3.8
59.57
77.31
ng/l
1.53
26
242
36
320
1.14
0.26
1.6
1.4
—
—
—
0
0
11
86
1.29
0.26
1.1
1.2
—
—
—
0
0
59
640
0.91
0.25
1.3
1.3
16.80
9.80
u/ml
0.22
25
247
37
412
0.89
0.25
1.3
1.5
—
—
—
0
0
12
96
1.26
0.25
1.4
1.4
123.75
229.13
pmol/l
0.37
12
91
11
137
0.80
0.24
2.5
1.6
196.64
317.94
mu/l
2.62
11
126
363
3587
1.11
0.23
5.7
5.9
2.66
2.72
mmol/l
0.56
340
3361
7
91
0.77
0.22
4.4
2.8
58.57
59.68
%
—
7
91
0
10
0.00
0.21
0.0
1.5
—
63.90
—
0
10
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
0.44
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
27.00
—
0
12
0
13
0.00
0.21
0.0
4.2
—
52.08
—
0
13
6
48
1.25
0.20
1.2
1.2
—
—
—
0
0
6
49
1.23
0.20
3.2
3.1
—
—
—
0
0
18
156
1.16
0.19
1.1
1.3
—
—
—
0
0
93
885
1.07
0.19
5.3
3.8
1.02
1.02
kg/l
0.37
60
599
7
61
1.15
0.17
1.0
1.5
—
—
—
0
0
13
110
1.19
0.17
1.2
1.3
—
—
—
0
0
15
129
1.17
0.17
2.9
3.7
157.56
189.19
mg/l
—
9
52
7
63
1.11
0.17
3.4
3.1
4.23
4.40
e9/l
—
7
63
5
69
0.72
0.17
1.0
1.1
—
—
—
0
0
116
1116
1.06
0.16
7.7
6.3
—
—
—
0
0
11
130
0.84
0.16
1.5
1.6
774.86
974.89
mu/l
0.85
11
105
21
188
1.12
0.15
4.4
3.0
47.95
37.10
u/ml
0.17
21
177
357
3538
1.07
0.15
5.1
5.2
4.58
4.62
mmol/l
0.32
334
3321
27
246
1.10
0.15
1.4
1.3
39.26
147.20
u/ml
—
8
100
17
191
0.89
0.14
1.9
1.5
0.47
0.36
mg/l
—
10
82
12
103
1.17
0.14
2.4
1.7
—
—
—
0
0
8
100
0.80
0.13
1.3
1.1
—
—
—
0
0
43
458
0.93
0.13
1.5
1.4
—
—
—
0
0
57
542
1.06
0.12
1.3
1.4
304.00
514.19
titre
—
10
124
107
1102
0.96
0.11
3.6
3.2
0.00
0.09
estimate
0.60
31
324
355
3526
1.05
0.10
5.0
5.1
1.46
1.45
mmol/l
0.10
332
3294
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
5
48
1.04
0.09
1.6
1.3
—
—
—
0
0
335
3374
0.96
0.09
6.6
6.4
38.75
39.15
mmol/mol
0.38
319
3191
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
6
56
1.07
0.08
1.2
1.2
120.13
88.40
mu/l
—
6
50
41
391
1.05
0.08
3.9
4.6
9.19
18.33
ug/l
0.36
32
320
112
1095
1.03
0.08
3.5
3.1
862.32
1039.59
ng/l
0.41
97
916
14
127
1.11
0.08
1.4
1.2
0.83
0.89
g/l
0.37
14
127
123
1254
0.97
0.07
5.7
5.2
1.57
2.10
ug/l
1.11
114
1142
32
304
1.06
0.07
1.2
1.2
—
—
—
0
0
29
275
1.06
0.07
1.8
1.7
1.04
1.41
g/l
1.06
24
250
8
91
0.88
0.07
1.4
1.9
—
—
—
0
0
37
354
1.05
0.07
2.0
2.4
15.19
13.67
nmol/l
0.28
32
322
48
463
1.04
0.06
1.4
1.6
—
—
—
0
0
154
1563
0.98
0.06
1.9
2.0
1.33
1.36
mmol/l
0.21
134
1314
59
572
1.04
0.06
1.6
1.7
1078.88
1241.23
nmol/l
0.80
50
433
13
141
0.92
0.05
1.4
1.3
—
—
—
0
0
10
109
0.92
0.04
1.1
1.2
—
—
—
0
0
89
878
1.02
0.03
5.2
5.0
—
—
—
0
0
97
958
1.02
0.03
2.3
2.9
309.11
343.57
umol/l
3.36
87
857
11
118
0.93
0.03
1.1
1.1
—
0.67
—
0
18
24
249
0.96
0.02
1.5
2.5
—
—
—
0
0
69
701
0.98
0.02
1.3
1.3
18.54
33.09
iu/ml
1.34
17
222
35
341
1.03
0.02
3.7
2.3
11.03
10.43
g/l
0.28
30
309
11
103
1.07
0.02
1.5
1.2
—
—
—
0
0
29
297
0.97
0.01
1.2
1.4
—
—
—
0
0
11
116
0.95
0.00
15.6
9.2
—
—
—
0
0
14
141
0.99
0.00
2.4
2.8
—
—
—
0
0
37
369
1.00
0.00
1.4
1.4
—
—
—
0
0
30
297
1.01
0.00
2.6
3.6
—
—
—
0
0
14
145
0.96
0.00
1.0
1.1
—
—
—
0
0
343
3426
1.01
0.00
5.1
5.1
5.88
5.93
mmol/l
0.26
323
3184
109
1085
1.01
0.00
4.9
3.9
0.00
0.01
estimate
0.99
35
369
12
124
0.97
0.00
1.1
1.2
1.54
1.57
g/l
0.08
12
124
0
9
0.00
0.00
0.0
8.9
—
4.88
—
0
9
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
73
730
1.00
-0.00
2.8
2.8
2.43
2.45
mmol/l
0.70
61
654
0
6
0.00
-0.00
0.0
1.0
—
53.33
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
2.47
—
0
7
7
72
0.97
-0.00
3.1
2.6
9.00
7.52
pmol/l
—
7
72
0
5
0.00
-0.00
0.0
1.0
—
73.46
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
69
0.87
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
59.33
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
170.33
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.8
—
50.14
—
0
5
5
55
0.91
-0.00
2.6
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
61
0.98
-0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.7
—
—
—
0
0
6
61
0.98
-0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
2.43
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
19
190
1.00
-0.00
1.6
2.1
0.00
0.02
estimate
—
5
64
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: Q17_ARTERIOVENOUS_MALFORMATION_OF_CEREBRAL_VESSELS – Arteriovenous malformation of cerebral vessels

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).