brain aneurysm: A congenital or acquired aneurysm within the cranium.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
400 |
4. Check minimum number of eventsNone |
400 |
5. Include endpointsNone |
400 |
6. Filter based on genotype QC (FinnGen only) |
358 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I67
- Name in latin
- Thrombosis non pyogenes systematis venosi intracranialis
Similar endpoints
↥List of similar endpoints to
Nonpyogenic thrombosis of intracranial venous system
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases, wide definition
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1945 | 1146 | 787 |
| Only index persons | 1787 | 1081 | 706 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 47.77 | 44.15 | 53.10 |
| Only index persons | 47.16 | 43.52 | 52.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 358 | 232 | 126 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | 52.03 | 48.98 | 57.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 374
- Matched controls
- 3740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.6
ICD-10 Finland
Nonpyogenic thrombosis of intracranial venous system
+∞
307.7
372
*
B01AA03
ATC
warfarin; systemic
21.2
208.3
226
251
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
13.4
123.3
145
169
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
21.9
89.3
70
39
AA1AD
NOMESCO Finland
CT of head and brain
7.6
86.9
206
520
N03AX14
ATC
levetiracetam; systemic
17.5
57.3
49
32
B01AB05
ATC
enoxaparin; parenteral
4.8
51.0
200
717
R51.80
ICD-10 Finland
Headache
5.1
49.1
148
429
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
14.1
46.9
45
36
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.2
40.2
103
257
XA800
NOMESCO Finland
Neuropsychological investigation
9.0
39.3
52
66
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
94.4
38.7
42
5
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
105.5
35.4
38
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
7.4
34.6
54
83
K99
ICPC
Cardiovascular disease other
13.9
33.6
32
25
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.3
32.6
76
173
PA2AD
NOMESCO Finland
CT angiography of brain
79.2
32.5
36
5
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
39.4
31.3
39
11
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
10.0
28.7
34
37
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.1
26.4
37
50
K94
ICPC
Phlebitis/thrombophlebitis
22.6
24.4
35
17
K90
ICPC
Stroke/cerebrovascular accident
60.3
24.4
28
5
I63.6
ICD-10 Finland
Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
+∞
24.2
23
*
R4120
NOMESCO Finland
Occupational therapy
5.4
23.9
51
106
K91
ICPC
Cerebrovascular disease
58.0
23.4
27
5
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.8
23.3
46
89
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
10.0
22.9
27
29
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.6
22.4
91
309
XF400
NOMESCO Finland
ECG with 12 standard connections
3.6
21.8
87
292
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
+∞
21.0
20
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
20.2
115
477
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
19.6
85
299
I69.8
ICD-10 Finland
Sequelae of other and unspecified cerebrovascular diseases
199.6
18.7
19
*
N03AF02
ATC
oxcarbazepine; oral
5.9
18.3
34
62
B01AB04
ATC
dalteparin; parenteral
5.4
18.0
37
74
WX892
NOMESCO Finland
Monitored bed care
4.2
16.8
49
131
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.7
15.6
53
158
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
15.7
15.6
25
17
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.2
15.5
27
46
H47.1
ICD-10 Finland
Papilloedema, unspecified
22.2
14.8
21
10
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
12.6
14.8
26
22
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.9
14.4
45
126
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
15.2
14.2
23
16
R4110
NOMESCO Finland
Physiotherapy
2.4
13.6
129
672
B01AE07
ATC
dabigatran etexilate; oral
6.4
13.6
23
38
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
145.1
13.5
14
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.5
13.5
34
81
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
11.6
13.2
24
22
K78
ICPC
Atrial fibrillation/flutter
4.0
12.9
38
102
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
16.2
12.8
20
13
ZXD35
NOMESCO Finland
Usual procedure
5.8
12.8
24
44
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
4.3
12.2
33
83
A02BC02
ATC
pantoprazole; systemic
2.3
12.2
271
1979
G44.2
ICD-10 Finland
Tension-type headache
2.6
12.1
81
356
N03AX18
ATC
lacosamide; systemic
22.2
12.1
17
8
D68.8
ICD-10 Finland
Other specified coagulation defects
13.1
11.8
20
16
I67.7
ICD-10 Finland
Cerebral arteritis, not elsewhere classified
+∞
11.5
11
*
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
+∞
11.5
11
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
11.5
11
*
G93.2
ICD-10 Finland
Benign intracranial hypertension
123.7
11.5
12
*
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
123.7
11.5
12
*
B01AB10
ATC
tinzaparin; parenteral
2.9
11.4
58
221
R4150
NOMESCO Finland
Neuropsychological rehabilitation
20.8
11.2
16
8
Z2445
NOMESCO Finland
Psychologist
4.1
11.2
32
84
WX872
NOMESCO Finland
Intensive care
4.2
10.7
29
73
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.9
10.7
32
87
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
10.5
10.6
20
20
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
10.5
49
177
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
+∞
10.5
10
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.6
10.1
34
100
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
15.1
10.1
16
11
R42
ICD-10 Finland
Dizziness and giddiness
2.3
10.0
92
465
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.8
9.9
55
219
JN4AD
NOMESCO Finland
Body CT examination
2.8
9.9
53
207
R51
ICD-10 Finland
Headache
3.4
9.9
37
117
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
20.7
9.9
14
7
TPH07
NOMESCO Finland
Cathetrisation of artery
2.9
9.8
50
190
H02AB06
ATC
prednisolone; systemic
2.0
9.8
188
1256
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
13.9
9.8
16
12
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.9
9.7
49
185
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
9.7
181
1195
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
5.2
9.7
20
40
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.3
9.5
38
125
Z3231
NOMESCO Finland
Registered nurse
2.1
9.5
119
679
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
102.5
9.5
10
*
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
+∞
9.4
9
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
11.1
9.4
17
16
C10AA05
ATC
atorvastatin; oral
2.0
9.3
141
863
PA6AD
NOMESCO Finland
CT of neck arteries
5.0
9.2
20
42
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
9.1
109
610
G41.9
ICD-10 Finland
Status epilepticus, unspecified
37.7
9.1
11
*
S01EC01
ATC
acetazolamide; systemic
7.8
9.1
20
27
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.9
9.0
45
169
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.5
9.0
31
93
AA1BD
NOMESCO Finland
Extensive CT of head and brain
7.1
9.0
21
31
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
24.7
9.0
12
5
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
8.9
53
219
WX882
NOMESCO Finland
High dependency care
6.9
8.8
21
32
H02AB09
ATC
hydrocortisone; systemic
4.7
8.7
20
44
WX730
NOMESCO Finland
Conventional respirator
12.0
8.6
15
13
B01AF02
ATC
apixaban; oral
2.6
8.4
50
206
G41.0
ICD-10 Finland
Grand mal status epilepticus
+∞
8.4
8
*
R20.2
ICD-10 Finland
Paraesthesia of skin
2.9
8.3
39
142
TAB00
NOMESCO Finland
Lumbar puncture
3.4
8.1
30
94
N03AG01
ATC
valproic acid; systemic, rectal
3.1
8.1
35
121
Z2446
NOMESCO Finland
Social worker
3.0
7.9
37
134
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
7.8
53
233
N29
ICPC
Neurological sympt/complt other
7.7
7.8
17
23
Z3226
NOMESCO Finland
Physiotherapist
2.1
7.6
80
423
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
25.6
7.6
10
*
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
25.6
7.6
10
*
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.8
7.6
38
143
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.7
7.5
24
68
R4130
NOMESCO Finland
Speech therapy
6.7
7.5
18
28
N05CF01
ATC
zopiclone; oral
1.9
7.5
125
780
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
13.7
7.4
12
9
R50.9
ICD-10 Finland
Fever, unspecified
2.2
7.4
68
341
W19
ICD-10 Finland
Unspecified fall
2.6
7.3
44
182
PAW37
NOMESCO Finland
Biopsy of temporal artery
+∞
7.3
7
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.6
7.3
17
38
K93
ICPC
Pulmonary embolism
10.3
7.1
13
13
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.8
7.0
36
137
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
7.0
57
272
L04AX01
ATC
azathioprine; systemic
3.5
7.0
24
72
N03AB02
ATC
phenytoin; systemic
8.5
6.9
14
17
XCK00
NOMESCO Finland
Perimetry
3.3
6.9
26
83
WX704
NOMESCO Finland
Intubation
2.7
6.8
38
151
M05BX04
ATC
denosumab; parenteral
3.4
6.8
24
73
N03AX16
ATC
[U] pregabalin
2.0
6.7
89
511
N05BA01
ATC
diazepam; systemic, rectal
2.3
6.6
55
264
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.6
72
386
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.1
6.6
28
96
H02AB02
ATC
dexamethasone; systemic
2.3
6.6
51
238
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.5
6.5
43
187
A28
ICPC
Limited function/disability NOS
2.2
6.4
59
295
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
71.0
6.4
7
*
RS121, ,
NOMESCO Finland
14.6
6.4
10
7
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
9.5
6.3
12
13
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
18.4
6.3
9
5
I61.6
ICD-10 Finland
Intracerebral haemorrhage, multiple localized
+∞
6.3
6
*
D32.05
ICD-10 Finland
Cerebral meninges
+∞
6.3
6
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
6.3
6
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.2
6.2
53
257
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
6.2
88
516
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.2
104
644
A03FA01
ATC
metoclopramide; systemic, rectal
1.9
6.1
91
544
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
100
45
29.97
141.45
1.1
1.1
—
—
—
0
0
89
42
27.50
123.00
1.4
1.1
2.70
2.77
u/ml
0.03
47
13
90
44
26.62
122.64
1.4
1.2
3.45
1.35
u/ml
1.07
31
17
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
93
62
19.63
109.75
4.4
3.8
0.47
0.30
iu/ml
3.76
70
35
162
410
6.21
65.31
6.0
2.2
30.06
29.43
s
0.52
157
401
212
869
4.32
43.51
3.5
2.0
164.49
277.65
u/l
0.74
205
822
261
1318
4.24
38.15
34.1
10.4
1.60
1.17
inr
17.86
226
1067
176
766
3.45
30.38
3.9
1.8
2.27
1.30
mg/l
0.99
137
581
37
16
25.51
26.67
1.4
1.2
—
—
—
0
0
28
28
10.73
25.01
1.4
1.1
—
—
—
0
0
127
510
3.26
24.08
5.5
4.2
0.82
0.82
mmol/l
0.06
121
488
257
1570
3.04
22.24
14.5
7.3
1.21
1.21
mmol/l
0.60
231
1359
281
1843
3.11
20.62
10.4
5.2
6.53
6.52
mmol/l
0.02
275
1721
224
1323
2.73
19.76
8.6
5.2
34.82
36.35
g/l
3.17
215
1240
228
1401
2.61
17.89
14.4
6.7
1.20
1.21
mmol/l
1.77
215
1296
35
71
5.34
16.76
1.6
1.2
11.50
16.53
e6/l
0.16
24
51
109
486
2.75
16.31
2.5
1.9
—
—
—
0
0
35
73
5.19
16.25
1.8
1.3
8142.46
129.55
e6/l
0.48
24
53
151
814
2.43
15.03
2.7
2.2
3.47
2.81
mg/l
1.18
124
711
86
356
2.84
14.68
2.4
1.8
—
—
—
0
0
49
148
3.66
14.10
15.2
14.8
16.03
15.87
%
0.13
49
142
77
307
2.90
14.05
16.7
10.3
0.93
0.99
mmol/l
0.05
63
262
83
345
2.81
14.01
3.2
2.0
346.77
370.53
nmol/l
0.53
78
325
22
39
5.93
12.09
1.0
1.0
—
—
—
0
0
38
110
3.73
11.60
1.8
2.1
0.96
3.78
ug/l
0.61
30
104
78
346
2.58
11.43
2.5
1.8
—
—
—
0
0
240
1695
2.16
11.31
10.7
6.7
10.70
11.99
umol/l
0.98
233
1616
113
599
2.27
11.13
5.6
3.6
337.36
412.51
ng/l
0.11
77
434
17
11
16.12
10.93
1.5
1.3
—
—
—
0
0
19
17
11.71
10.67
2.5
2.1
11.57
12.21
umol/l
0.10
19
17
54
210
2.84
10.18
19.4
9.3
24.07
24.85
mmol/l
1.28
54
210
159
1007
2.01
9.58
4.1
2.6
145.10
62.17
u/l
0.49
153
937
43
153
3.05
9.48
1.9
1.6
—
—
—
0
0
258
1939
2.07
9.47
18.0
9.5
4.19
3.98
e9/l
0.69
230
1696
305
2447
2.34
9.41
5.9
4.1
12.71
10.25
mm/h
2.02
288
2281
16
14
11.88
9.15
1.4
1.1
—
—
—
0
0
145
902
1.99
9.08
4.8
3.2
0.27
0.32
e6/l
0.20
102
639
80
397
2.29
9.03
13.3
7.0
104.54
104.24
mmol/l
0.17
80
397
64
294
2.42
8.59
2.6
2.9
0.23
0.22
g/l
0.33
58
277
19
26
7.64
8.55
3.5
2.3
—
—
—
0
0
170
1135
1.91
8.51
5.0
3.2
—
—
—
0
0
66
309
2.38
8.49
6.1
4.8
1.57
1.57
mmol/l
0.00
60
263
87
460
2.16
8.37
1.5
1.6
1079.78
1224.52
nmol/l
0.81
63
347
213
1536
1.90
8.36
3.9
2.8
—
—
estimate
—
0
0
92
502
2.10
8.14
3.7
3.1
3.38
2.69
e6/l
0.22
43
236
126
773
1.95
8.04
3.5
2.3
—
—
—
0
0
19
30
6.61
7.81
2.2
2.1
144.43
191.42
e6/l
0.57
14
24
59
273
2.38
7.77
18.6
8.8
1.30
1.36
mmol/l
0.18
59
268
204
1482
1.83
7.52
3.4
2.6
74.82
75.87
nmol/l
0.21
184
1350
18
28
6.70
7.50
1.8
2.1
398.62
497.71
e6/l
0.52
13
21
298
2456
2.05
7.26
14.8
7.8
83.54
78.98
u/l
0.59
289
2329
165
1140
1.80
7.04
5.3
3.3
2.33
2.35
mmol/l
1.25
146
1046
18
32
5.85
6.85
1.4
1.1
—
—
—
0
0
18
32
5.85
6.85
1.4
1.1
—
—
—
0
0
218
1648
1.77
6.73
4.4
3.2
105.23
97.28
ug/l
0.28
202
1560
27
90
3.16
6.64
1.6
1.3
—
—
—
0
0
48
217
2.39
6.63
2.1
1.6
—
—
—
0
0
23
70
3.44
6.53
3.3
2.1
124.53
129.31
g/l
0.32
17
54
92
542
1.92
6.44
3.4
3.0
0.76
0.90
e6/l
0.29
42
274
160
1130
1.73
6.10
4.5
3.3
19.82
36.50
ng/l
2.09
105
721
71
389
2.02
6.10
2.9
3.4
8.13
7.83
umol/l
0.03
64
339
29
107
2.85
6.01
1.6
1.4
0.01
0.07
iu/ml
—
6
15
182
1337
1.70
5.97
2.4
2.0
94.98
96.16
pmol/l
0.13
116
686
44
201
2.35
5.94
6.8
5.0
24.31
23.96
mmol/l
0.43
44
201
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
12
15
8.22
5.88
1.3
1.1
—
—
—
0
0
43
196
2.35
5.83
8.3
5.0
1.99
1.69
mmol/l
0.20
25
148
162
1169
1.68
5.57
4.6
3.3
34.17
30.75
u/l
0.50
156
1097
14
27
5.34
5.13
1.2
1.0
—
—
—
0
0
16
36
4.60
5.11
1.7
2.0
—
—
—
0
0
120
817
1.69
5.04
4.0
2.7
323.91
336.43
umol/l
0.68
105
736
356
3263
2.89
5.00
35.3
15.8
3.93
3.95
mmol/l
1.57
351
3192
11
16
7.05
4.98
1.0
1.0
—
—
—
0
0
45
228
2.11
4.74
8.8
4.9
5.02
5.15
kpa
0.59
45
220
126
881
1.65
4.73
2.0
1.6
17.75
21.23
nmol/l
2.91
118
750
14
30
4.81
4.73
1.7
2.2
—
—
—
0
0
354
3251
2.66
4.66
31.6
13.7
20.82
22.10
mg/l
0.37
314
2600
34
155
2.31
4.63
1.3
1.4
—
—
—
0
0
53
289
1.97
4.58
5.8
4.2
5.89
33.11
ug/l
0.57
48
228
8
8
10.18
4.54
1.4
1.1
—
—
—
0
0
8
8
10.18
4.54
1.4
1.3
—
—
—
0
0
8
8
10.18
4.54
1.4
1.3
—
—
—
0
0
10
15
6.82
4.49
1.3
1.3
—
—
—
0
0
269
2287
1.63
4.27
4.4
3.4
42.80
44.94
u/l
0.24
261
2176
15
39
3.96
4.24
2.5
1.5
—
—
—
0
0
92
613
1.66
4.10
4.1
2.5
2.45
2.44
mmol/l
0.40
84
543
24
99
2.52
4.06
2.5
1.8
—
—
—
0
0
54
309
1.87
4.05
3.9
3.1
—
—
—
0
0
45
242
1.98
4.05
7.5
3.6
1.21
1.23
mmol/l
1.23
40
209
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
9
14
6.56
4.00
1.2
2.9
223.00
128.64
%
—
9
14
23
94
2.54
3.96
2.6
1.6
—
—
—
0
0
40
209
2.02
3.90
1.4
2.3
6.66
7.78
ug/l
0.18
32
189
9
15
6.12
3.83
1.2
1.5
—
—
—
0
0
10
20
5.11
3.71
1.5
1.4
—
—
—
0
0
10
20
5.11
3.71
1.5
1.4
—
—
—
0
0
17
62
2.82
3.64
1.5
1.3
—
—
—
0
0
17
62
2.82
3.64
1.5
1.3
—
—
—
0
0
21
86
2.53
3.62
2.0
1.6
—
—
—
0
0
21
87
2.50
3.54
3.6
2.8
1.62
2.31
index
—
10
48
11
26
4.33
3.53
1.4
2.2
0.40
0.60
e9/l
0.96
11
26
23
102
2.34
3.36
1.5
1.3
—
—
—
0
0
19
77
2.55
3.35
3.3
3.2
1.88
2.51
ratio
—
10
39
14
48
2.99
3.33
1.2
1.1
—
—
—
0
0
22
96
2.37
3.33
1.2
1.1
—
4.80
—
0
16
15
55
2.80
3.19
1.9
1.3
—
—
—
0
0
24
112
2.22
3.14
1.5
1.3
—
—
—
0
0
8
16
5.08
3.06
2.1
1.7
—
—
—
0
0
6
8
7.60
3.06
3.8
1.9
1.92
2.04
ratio
—
6
8
6
8
7.60
3.06
1.3
1.1
—
—
—
0
0
88
622
1.54
3.01
1.6
1.7
463.84
436.84
pmol/l
0.36
75
535
15
57
2.70
3.00
2.7
1.8
—
—
—
0
0
8
17
4.78
2.93
1.1
1.0
2111.25
1606.88
miu/ml
—
8
17
9
22
4.16
2.90
5.4
2.4
—
—
—
0
0
6
9
6.75
2.88
1.0
1.1
—
—
—
0
0
6
9
6.75
2.88
1.5
1.2
—
—
—
0
0
13
47
2.83
2.84
2.7
1.3
—
—
—
0
0
17
71
2.46
2.84
1.9
1.5
—
—
—
0
0
33
181
1.90
2.84
3.5
2.3
10448.56
4893.67
u/l
0.40
14
68
32
174
1.92
2.83
5.0
3.7
1.33
1.24
%
0.12
32
174
14
53
2.71
2.82
2.1
1.8
—
—
—
0
0
17
73
2.39
2.69
2.0
1.6
—
—
—
0
0
8
19
4.28
2.69
2.1
1.6
—
—
—
0
0
39
232
1.76
2.61
4.9
4.2
75.62
72.94
ng/l
0.07
34
209
50
320
1.65
2.58
3.7
2.4
29.36
32.92
u/l
0.39
44
266
22
108
2.10
2.57
2.0
1.9
—
—
—
0
0
14
56
2.56
2.56
8.6
3.1
4.94
5.02
kpa
0.23
14
56
5
7
7.22
2.55
1.4
1.1
—
—
—
0
0
5
7
7.22
2.55
1.4
1.3
—
—
—
0
0
20
95
2.17
2.53
2.8
2.9
—
—
—
0
0
26
137
1.96
2.53
1.8
1.6
22.90
8.11
u/ml
—
5
30
326
3021
1.62
2.51
4.7
4.0
1.39
1.26
mmol/l
2.39
300
2816
128
1012
1.40
2.42
5.3
3.1
0.00
0.02
estimate
1.47
45
305
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
6
12
5.06
2.41
1.0
1.0
126.17
140.00
%
—
6
12
10
33
3.08
2.37
1.2
1.0
—
—
—
0
0
206
1768
1.37
2.33
5.1
3.7
26.52
3.72
estimate
0.40
50
378
6
13
4.67
2.28
3.0
1.8
130.90
65.76
ug/l
—
6
13
24
128
1.94
2.27
2.5
1.6
1.29
1.19
g/l
0.53
24
121
204
1753
1.36
2.26
5.1
3.7
0.00
0.00
estimate
0.50
51
372
7
18
3.94
2.26
2.3
1.7
—
—
—
0
0
20
100
2.06
2.25
2.3
1.7
—
—
—
0
0
11
43
2.60
2.09
1.3
1.3
0.18
0.16
nmol/l
—
6
27
5
10
5.05
2.07
1.0
1.3
—
—
—
0
0
23
125
1.90
2.07
2.6
1.6
0.28
0.23
g/l
1.03
23
119
7
20
3.55
2.06
1.3
8.2
—
36.57
u/ml
—
0
7
9
32
2.86
2.01
5.9
2.7
125.22
43.04
u/ml
—
9
32
356
3411
1.91
1.96
20.7
11.2
27.27
26.19
u/l
0.59
348
3336
8
27
3.00
1.94
1.9
2.0
—
—
—
0
0
205
1788
1.32
1.94
5.1
3.7
0.00
0.02
estimate
0.80
50
354
105
835
1.36
1.86
2.6
3.3
1834.23
864.72
ng/l
1.16
86
698
37
240
1.60
1.84
1.9
1.4
31.22
23.31
iu/l
0.61
29
206
7
24
2.95
1.73
2.9
1.5
—
—
—
0
0
325
3064
1.46
1.71
26.5
12.8
86.28
85.67
ml/min/173m2
0.19
313
2820
27
165
1.69
1.70
1.7
1.5
0.47
0.29
mg/l
0.75
14
71
79
610
1.37
1.67
1.3
1.3
6.31
8.63
u/ml
0.23
29
238
6
19
3.19
1.66
1.2
1.0
—
—
—
0
0
86
675
1.36
1.64
1.3
1.4
15.82
26.30
iu/ml
1.57
21
197
282
2608
1.33
1.59
5.4
4.4
14.76
14.62
pmol/l
0.41
262
2422
17
92
1.89
1.58
1.2
1.3
—
0.88
—
0
5
317
2985
1.41
1.58
6.6
5.9
38.79
38.55
mmol/mol
0.15
299
2825
8
33
2.45
1.54
1.5
1.6
—
—
—
0
0
8
33
2.45
1.54
1.1
1.2
94.00
107.61
pmol/l
—
8
33
34
227
1.55
1.53
2.6
3.8
4.22
4.60
pmol/l
1.23
29
201
5
15
3.36
1.53
1.8
1.3
—
—
—
0
0
5
15
3.36
1.53
1.8
1.3
—
—
—
0
0
7
27
2.62
1.52
1.0
5.0
99.43
98.00
%
—
7
27
323
3060
1.41
1.47
6.4
5.4
1.72
1.86
mu/l
1.00
304
2870
5
16
3.15
1.44
1.2
1.8
—
—
—
0
0
15
81
1.89
1.42
1.7
1.4
—
—
—
0
0
333
3179
1.43
1.37
5.6
4.8
4.66
4.70
mmol/l
0.27
313
2997
336
3214
1.45
1.36
6.3
5.4
2.73
2.76
mmol/l
0.25
316
3022
17
99
1.75
1.29
1.8
2.0
2.59
5.27
iu/l
—
6
37
8
35
2.31
1.27
1.1
1.2
—
—
—
0
0
331
3165
1.40
1.27
5.6
4.7
1.44
1.49
mmol/l
1.36
308
2975
8
36
2.25
1.25
2.4
2.7
107.37
105.00
mmol/l
—
8
36
10
49
2.07
1.23
1.7
1.3
—
—
—
0
0
10
49
2.07
1.23
1.7
1.3
—
—
—
0
0
8
37
2.19
1.22
1.1
1.2
—
—
—
0
0
8
37
2.19
1.22
1.1
1.2
—
—
—
0
0
8
37
2.19
1.22
1.1
1.2
—
—
—
0
0
5
19
2.65
1.22
3.0
3.7
379.80
651.74
u/ml
—
5
19
107
902
1.26
1.20
1.3
1.3
0.78
1.02
u/ml
0.40
33
248
10
50
2.03
1.17
1.7
1.3
—
—
—
0
0
10
50
2.03
1.17
1.7
1.3
—
—
—
0
0
10
50
2.03
1.17
1.7
1.3
—
—
—
0
0
10
50
2.03
1.17
1.7
1.3
—
—
—
0
0
8
39
2.07
1.16
1.1
1.2
—
—
—
0
0
8
40
2.02
1.12
1.3
1.1
—
77.60
—
0
5
5
21
2.40
1.09
1.2
1.2
—
—
—
0
0
5
21
2.40
1.09
1.2
1.2
—
—
—
0
0
7
33
2.14
1.06
1.3
1.1
—
—
—
0
0
16
98
1.66
1.05
1.3
1.3
—
—
—
0
0
13
75
1.76
1.04
1.8
1.8
149.40
155.41
au/ml
—
5
21
11
60
1.86
1.04
1.8
1.4
—
—
—
0
0
152
1351
1.21
1.03
5.2
3.5
0.00
0.04
estimate
1.64
46
320
12
68
1.79
1.01
2.1
1.9
—
—
—
0
0
11
61
1.83
0.99
14.5
2.9
16.77
7.82
pmol/l
0.82
11
61
7
36
1.96
0.97
2.6
2.7
1.22
1.19
mmol/l
—
7
36
33
245
1.38
0.93
5.5
2.5
79.39
68.93
ml/min/173m2
1.65
21
100
37
281
1.35
0.91
1.4
1.3
97.16
156.02
u/ml
—
10
117
6
29
2.09
0.89
2.7
5.0
—
—
—
0
0
153
1376
1.19
0.89
2.2
1.9
1.53
1.37
mmol/l
1.19
142
1178
16
239
0.65
0.88
1.8
1.6
836.35
956.52
mu/l
0.24
11
199
6
30
2.02
0.87
2.2
1.8
—
—
—
0
0
8
46
1.75
0.83
1.1
1.2
—
—
—
0
0
319
3076
1.25
0.80
5.3
4.7
5.93
5.86
mmol/l
0.33
294
2859
5
97
0.51
0.79
2.0
1.9
—
—
—
0
0
242
2281
1.17
0.75
3.7
3.5
—
—
—
0
0
122
1096
1.17
0.70
4.5
3.4
7.85
7.83
mmol/l
0.01
107
934
5
27
1.86
0.68
1.4
1.5
—
—
—
0
0
8
129
0.61
0.65
1.9
1.8
—
—
—
0
0
17
121
1.42
0.63
1.4
1.3
—
—
—
0
0
44
363
1.24
0.62
4.9
4.3
31.41
31.83
%
0.08
29
237
34
275
1.26
0.58
1.8
2.1
—
—
—
0
0
10
65
1.55
0.56
8.9
3.4
42.50
31.36
u/ml
—
10
65
40
332
1.23
0.55
1.8
2.2
—
—
—
0
0
106
960
1.15
0.54
5.7
3.7
0.00
0.01
estimate
0.74
49
356
73
649
1.16
0.48
1.4
1.5
—
—
—
0
0
108
992
1.12
0.45
5.2
4.1
11.56
8.11
mg/mmol
0.28
67
614
7
51
1.38
0.44
1.4
1.4
327.00
309.17
mu/l
—
7
41
9
131
0.68
0.43
1.6
1.4
—
—
—
0
0
15
195
0.76
0.42
1.1
1.3
—
—
—
0
0
5
33
1.52
0.41
1.4
1.2
—
—
—
0
0
5
36
1.39
0.38
1.0
1.0
—
—
—
0
0
5
37
1.36
0.37
2.0
1.2
—
—
—
0
0
10
134
0.74
0.35
1.5
1.5
—
—
—
0
0
6
47
1.28
0.32
2.8
2.0
12.92
13.16
%
—
6
47
19
156
1.23
0.31
1.3
1.4
137.17
267.96
miu/ml
—
6
79
359
3555
1.25
0.30
46.1
21.4
269.30
254.57
e9/l
3.38
353
3503
7
56
1.25
0.29
1.3
1.1
—
1.64
—
0
14
8
62
1.30
0.28
1.8
1.6
—
—
—
0
0
359
3558
1.22
0.27
46.0
21.3
4.44
4.51
e12/l
1.91
352
3495
5
72
0.69
0.26
4.0
2.5
27.60
51.23
ug/min
—
5
40
5
41
1.22
0.22
1.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
6
48
1.25
0.20
2.2
1.1
1.49
1.47
g/l
—
6
43
9
111
0.81
0.20
1.1
1.1
—
—
—
0
0
17
146
1.17
0.19
1.2
1.5
—
—
—
0
0
7
60
1.17
0.18
2.0
1.3
—
—
—
0
0
65
613
1.07
0.17
4.8
4.3
22.13
22.97
%
0.12
28
280
5
70
0.71
0.17
1.4
1.2
—
—
—
0
0
14
161
0.86
0.15
1.6
1.5
—
—
—
0
0
52
551
0.93
0.14
2.2
2.2
—
—
—
0
0
50
472
1.07
0.13
3.3
3.0
0.72
0.73
ug/l
0.02
35
293
9
110
0.81
0.13
1.1
1.1
—
—
—
0
0
48
508
0.94
0.13
2.2
2.1
—
—
—
0
0
33
307
1.08
0.12
1.5
1.8
3.54
3.46
mmol/l
0.15
18
226
11
95
1.16
0.11
1.8
1.4
146.18
61.30
pmol/l
0.45
11
90
35
328
1.07
0.11
5.9
6.2
—
—
—
0
0
43
407
1.06
0.11
1.6
2.0
3.23
3.41
ratio
0.67
30
322
5
44
1.14
0.10
2.8
1.6
—
—
—
0
0
6
54
1.11
0.09
1.3
1.4
—
—
—
0
0
15
136
1.11
0.08
1.1
1.1
1.56
1.55
g/l
0.10
15
136
7
81
0.86
0.07
1.4
1.3
—
—
—
0
0
7
80
0.87
0.07
1.6
1.6
42.16
50.61
ug/l
—
7
80
10
111
0.90
0.06
1.7
1.7
—
—
—
0
0
74
758
0.97
0.06
4.8
3.7
1.02
1.02
kg/l
0.15
51
491
77
788
0.97
0.06
2.0
1.7
—
—
—
0
0
26
248
1.05
0.05
1.7
1.5
—
—
—
0
0
79
774
1.03
0.05
5.2
5.0
2.45
2.24
ug/l
0.10
72
700
15
140
1.07
0.04
1.1
1.2
1.01
0.90
g/l
0.26
15
140
10
92
1.09
0.03
2.3
1.6
—
—
—
0
0
14
134
1.05
0.00
1.9
1.6
—
—
—
0
0
20
198
1.01
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.02
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
41.50
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
2.24
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint I9_THROMBICV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBICV | 2.151 [1.58, 2.92] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 100 out of 916 females with I9_THROMBICV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBICV | 2.538 [1.86, 3.46] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 619 males with I9_THROMBICV died.
Mortality risk
Mortality risk for people of age
years, who have I9_THROMBICV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.224% | 0.476% |
| 5 | 1.437% | 3.118% |
| 10 | 3.209% | 7.444% |
| 15 | 5.841% | 13.79% |
| 20 | 10.125% | 22.083% |
Relationships between endpoints
↥Index endpoint: I9_THROMBICV – Nonpyogenic thrombosis of intracranial venous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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