Acrodermatitis continua

L12_PSORI_ACRODERM

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L40.2 Hospital discharge: ICD-9 — 6961C Hospital discharge: ICD-8 — 68696 Cause of death: ICD-10 — L40.2 Cause of death: ICD-9 — 6961C Cause of death: ICD-8 — 68696 2 out of 7 registries used, show all original rules.	80
4. Check minimum number of events None	80
5. Include endpoints None	80
6. Filter based on genotype QC (FinnGen only)	74

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L40
Name in latin: Acrodermatitis continua (Hallopeau)

NAME	L12_PSORI_ACRODERM
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L402
HD_ICD_9	6961C
HD_ICD_8	68696
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L402
COD_ICD_9	6961C
COD_ICD_8	68696
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acrodermatitis continua based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	449	266	181
Only index persons	419	250	169
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	55.60	54.91	56.85
Only index persons	55.27	54.78	55.99

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	74	46	28
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	55.54	52.59	60.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
76: Matched controls
760

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L40.2

ICD-10 Finland

Acrodermatitis continua

+∞

103.8

D07AD01

ATC

clobetasol; topical

29.0

50.5

L04AX03

ATC

methotrexate; systemic

23.6

45.1

D05BB02

ATC

acitretin; oral

+∞

37.7

D05AX52

ATC

calcipotriol, combinations; topical

68.2

35.7

D07XC01

ATC

betamethasone; topical

19.4

35.6

L40.0

ICD-10 Finland

Psoriasis vulgaris

229.9

30.1

D05AX02

ATC

calcipotriol; topical

152.2

21.9

E0000UV, ,

ATC

12.5

20.1

227

L40.5

ICD-10 Finland

Arthropathic psoriasis

+∞

19.6

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

231.9

18.4

D07AC01

ATC

betamethasone; topical

8.0

17.7

170

319

Kela drug reimbursment

Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)

+∞

17.3

E000001, ,

ATC

6.2

13.9

L40.9

ICD-10 Finland

Psoriasis, unspecified

+∞

12.9

L40.3

ICD-10 Finland

Pustulosis palmaris et plantaris

154.4

12.9

D07AC13

ATC

mometasone; topical

5.1

11.4

130

L01BA01

ATC

methotrexate; systemic

24.1

10.2

L30.9

ICD-10 Finland

Dermatitis, unspecified

4.8

10.2

109

D05AX03

ATC

calcitriol; topical

113.6

9.7

E000003, ,

ATC

12.5

9.6

L40.8

ICD-10 Finland

Other psoriasis

+∞

9.6

M07.3

ICD-10 Finland

Other psoriatic arthropathies

+∞

9.6

L30.3

ICD-10 Finland

Infective dermatitis

19.2

8.9

S91

ICPC

Psoriasis

56.8

8.9

D02AE01

ATC

carbamide; topical

11.4

8.2

E000002, ,

ATC

5.3

7.7

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

4.9

7.6

E000006, ,

ATC

9.5

7.5

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

7.0

R50.9

ICD-10 Finland

Fever, unspecified

4.0

6.6

TQW80

NOMESCO Finland

Local dermatologic skincare

16.2

6.6

L04AB04

ATC

adalimumab; parenteral

12.6

6.5

L04AC18

ATC

risankizumab; parenteral

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42870588) Differential panel, method unspecified - Blood

226

4.29

8.75

18.4

5.4

—

(3000494) Fungus identified in Specimen by Culture

4.49

8.37

2.3

1.3

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

21.08

7.86

1.2

1.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

4.58

7.03

1.5

—

(3017181) Myelocytes/Leukocytes in Blood

4.21

6.77

5.7

4.2

0.45

0.59

0.22

(3002179) Metamyelocytes/Leukocytes in Blood

4.22

6.58

5.4

4.0

0.11

1.00

—

(40768443) Skin Pathology biopsy report

6.91

6.23

1.3

1.1

—

(3021440) Promyelocytes/Leukocytes in Blood

4.02

5.96

6.0

4.4

0.00

0.06

—

(3025159) Blasts/Leukocytes in Blood

3.76

5.43

6.4

4.9

0.00

0.05

—

(40760892) CBC W Ordered Manual Differential panel - Blood

153

2.89

4.68

12.4

5.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

6.24

4.48

1.9

2.0

—

(3023520) Reticulocytes [#/volume] in Blood

3.55

4.46

5.3

3.6

79.92

74.72

e9/l

0.20

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

7.12

4.12

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.14

4.01

2.1

1.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

5.07

3.57

2.0

2.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

100

2.69

3.41

2.8

1.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.69

3.21

1.6

1.5

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

10.57

3.02

1.2

2.8

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

10.57

3.02

1.2

2.8

—

(3035933) Granulocytes/Leukocytes in Blood

5.12

3.01

3.3

2.4

56.56

65.65

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

408

2.42

2.90

4.5

4.2

6.42

6.32

mmol/l

0.18

385

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.83

2.88

1.3

1.4

—

(3016018) Differential panel - Cerebral spinal fluid

8.80

2.79

1.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

381

2.29

2.77

8.3

6.5

11.30

11.23

umol/l

0.01

365

(3035715) Granulocytes [#/volume] in Blood

5.02

2.66

1.9

2.5

4.86

5.78

e9/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.87

2.60

1.8

1.4

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

7.54

2.59

1.2

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

145

2.21

2.52

1.8

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

522

2.69

2.47

16.3

8.2

80.35

78.36

u/l

0.17

502

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

6.59

2.41

1.0

1.3

—

(3044941) Cell count panel - Synovial fluid

6.59

2.41

1.2

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

6.59

2.41

1.4

1.1

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

6.59

2.41

1.0

1.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.76

2.34

1.1

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

455

2.16

2.14

7.7

4.4

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

500

2.30

2.12

11.7

4.5

13.79

11.41

mm/h

0.81

468

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

4.38

1.85

1.8

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

154

1.93

1.80

3.6

2.3

—

(3044290) Cell count panel - Cerebral spinal fluid

4.04

1.74

1.2

1.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

123

1.98

1.74

1.7

1.8

—

(3042936) Bacteria identified in Isolate by Culture

2.09

1.73

2.5

1.8

—

(3023368) Bacteria identified in Blood by Culture

174

1.86

1.69

6.4

4.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.67

1.65

1.9

1.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

119

1.92

1.58

4.9

3.0

148.62

87.34

ng/l

0.28

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

144

1.86

1.56

1.4

1.7

0.70

1.39

mg/l

0.77

114

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

251

1.73

1.51

4.2

3.5

15.22

33.60

ng/l

1.36

173

(3031040) Bacteria [#/volume] in Urine by Automated count

439

1.79

1.47

8.1

4.5

—

73.15

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

3.27

1.46

3.8

2.8

28.36

24.68

mmol/l

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

1.37

0.0

1.6

—

883.31

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.00

1.36

3.1

1.6

—

(3022313) Gas panel - Capillary blood

2.52

1.27

3.3

3.6

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.74

1.23

1.4

1.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

349

1.62

1.21

6.7

6.1

1.22

mmol/l

0.11

308

(3012544) pH of Venous blood

2.00

1.21

2.1

3.0

7.39

7.38

—

(40768804) Tissue Pathology biopsy report

267

1.58

1.11

1.9

2.1

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.47

1.11

1.6

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.81

1.10

3.4

6.1

104.47

104.37

mmol/l

0.03

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

2.36

1.05

1.2

1.0

—

56.14

—

(3034770) Mitochondria Ab [Titer] in Serum

2.36

1.05

1.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

1.00

0.0

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

657

2.22

0.98

31.1

15.0

17.92

22.93

mg/l

0.93

542

(3044640) Blood type and Crossmatch panel - Blood

217

1.54

0.98

3.6

2.3

—

(3009508) Creatinine [Moles/volume] in Urine

209

1.54

0.95

2.9

3.0

6.97

7.61

mmol/l

0.36

174

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

317

1.47

0.87

3.5

2.7

—

estimate

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

133

1.57

0.84

1.3

1.4

31.43

14.25

u/ml

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.78

0.83

2.3

1.8

1.09

1.31

g/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

196

1.50

0.83

4.0

3.9

4.22

8.95

mg/mmol

0.85

123

(3018095) Leukocytes [#/volume] in Urine

262

1.46

0.82

6.8

4.3

19.08

62.58

e6/l

1.26

181

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.81

0.0

1.5

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

117

1.58

0.80

1.9

2.8

0.78

0.81

mmol/l

0.68

111

(3030467) Casts [#/volume] in Urine by Automated count

189

1.48

0.78

4.2

3.3

0.33

0.44

e6/l

0.13

135

(3000764) Benzodiazepines [Presence] in Urine

2.25

0.77

1.0

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

101

1.60

0.77

3.3

1.07

0.85

e6/l

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.16

0.76

1.2

—

(3028300) Cannabinoids [Presence] in Urine

2.16

0.76

1.0

1.2

—

(3027008) Opiates [Presence] in Urine

2.16

0.76

1.0

1.2

—

(3016879) Cocaine [Presence] in Urine

2.16

0.76

1.0

1.2

—

(3018418) pH of Serum or Plasma

218

1.45

0.76

2.6

4.0

7.41

7.40

1.35

161

(40761536) Microorganisms panel - Urine sediment

1.69

0.76

3.4

3.3

—

(3026008) Bacteria identified in Urine by Culture

200

1.46

0.75

4.3

2.9

—

(40758558) Short blood count panel - Blood

228

1.44

0.74

12.1

6.2

—

(3027944) Amphetamines [Presence] in Urine

2.07

0.74

1.0

1.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.99

0.72

2.0

2.8

—

(3002582) Erythrocytes [#/volume] in Urine

230

1.42

0.70

4.3

3.4

14.09

312.96

e6/l

0.54

176

(40761535) Cells panel - Urine sediment

1.69

0.69

4.3

2.8

—

(36304419) Bacteria [Presence] in Urine

187

1.41

0.64

4.2

2.9

—

estimate

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.63

0.63

1.6

1.4

—

(3012516) Albumin [Mass/volume] in Urine

197

1.40

0.62

3.1

22.37

52.94

mg/l

1.15

130

(3035350) Ketones [Presence] in Urine by Test strip

371

1.37

0.62

6.2

4.0

0.00

estimate

-0.00

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.61

0.0

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

121

0.62

0.61

1.5

—

(40768797) Stomach Pathology biopsy report

1.51

0.59

1.2

1.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

153

1.42

0.58

2.0

1.4

3.10

2.35

g/l

0.43

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.57

0.57

3.5

1.8

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

119

1.44

0.54

3.0

2.7

2.45

2.46

mmol/l

0.15

107

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.54

0.53

2.0

2.5

1.97

5.81

ug/l

—

(3009261) Glucose [Presence] in Urine by Test strip

371

1.30

0.47

5.4

4.1

0.00

estimate

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.65

0.44

2.8

2.2

0.58

0.62

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.55

0.42

2.8

2.2

0.82

1.14

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.37

0.42

1.3

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

0.00

0.41

0.0

2.7

—

0.22

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.8

—

17.97

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.6

—

41.70

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.40

0.0

4.8

—

39.70

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.40

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.39

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.39

0.0

1.5

—

0.97

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.39

0.0

1.5

—

0.87

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.39

0.0

1.5

—

1.26

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

126

1.34

0.39

1.9

1.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.34

0.39

1.6

3.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.38

0.38

3.4

3.5

3.54

4.27

e6/l

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.46

0.36

3.2

2.7

—

(3002256) Pathology report gross observation

0.69

0.33

1.1

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

363

1.22

0.31

5.5

4.0

0.00

estimate

-0.00

(40761511) CBC panel - Blood by Automated count

675

0.74

0.30

26.1

13.5

—

(3013512) EKG study

227

1.22

0.29

3.6

3.3

—

(1761868) Lipid panel - Serum or Plasma

272

0.83

0.26

3.4

3.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

288

1.19

0.26

2.8

2.0

1.47

1.24

mmol/l

1.04

250

(3022145) Colonoscopy Study observation

1.32

0.25

1.9

1.4

—

(3015736) pH of Urine

299

1.18

0.25

6.6

3.4

6.20

6.19

0.03

173

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.34

0.24

5.0

8.5

0.48

0.64

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.34

0.24

2.4

2.2

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.30

0.23

5.0

8.4

1.24

1.28

—

(3019060) Gas panel - Arterial blood

1.30

0.23

7.4

3.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

281

1.17

0.23

2.1

2.0

94.15

100.14

pmol/l

0.30

148

(3041096) Erythrocytes [Presence] in Urine by Automated

213

1.19

0.22

4.0

3.5

0.00

estimate

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.2

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.21

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

2.83

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

2.6

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

413

1.16

0.20

3.7

3.1

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.23

0.19

2.7

5.6

1.35

1.30

mmol/l

—

(3000991) Gas panel - Venous blood

1.21

0.18

2.7

6.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.73

0.17

2.0

1.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.20

0.17

16.5

8.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.16

0.17

1.6

—

(3003694) ABO and Rh group [Type] in Blood

190

0.86

0.15

1.5

1.6

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

664

1.23

0.14

25.5

16.8

3.89

3.97

mmol/l

1.40

653

(3019550) Sodium [Moles/volume] in Serum or Plasma

663

1.24

0.14

25.4

16.7

139.34

139.76

mmol/l

0.71

655

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

133

1.16

0.13

4.3

5.4

17.06

21.70

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

281

1.11

0.12

4.8

3.7

0.00

estimate

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.15

0.10

4.2

6.3

25.58

25.19

mmol/l

—

(3000492) Spirometry study

1.05

0.08

1.9

1.4

—

(36660697) Celiac disease serology panel - Serum

1.03

0.08

1.3

1.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

686

1.26

0.08

40.7

19.4

72.37

74.91

umol/l

0.40

679

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

643

1.08

0.02

6.6

4.9

4.34

4.68

mmol/l

2.15

606

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

172

0.99

0.00

5.7

5.9

2.16

1.80

ug/l

0.22

151

(3029937) Albumin [Presence] in Urine by Test strip

207

1.02

0.00

5.2

3.9

0.00

estimate

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

0.0

1.0

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.0

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.99

0.00

2.4

2.0

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

3.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.5

—

4.60

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.2

—

89.00

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.97

-0.00

3.4

3.1

27.71

32.05

u/l

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

2.2

—

14.17

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.6

—

105.40

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.5

—

11.02

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.5

—

16.77

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

3.2

—

0.60

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.02

-0.00

1.1

1.9

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.0

—

9.85

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.93

-0.00

2.3

1.8

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.4

—

62.80

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

-0.00

0.0

2.7

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.2

—

15.97

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.6

—

607.20

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.1

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

0.31

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

-0.00

0.0

4.3

—

35.50

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PSORI_ACRODERM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_PSORI_ACRODERM.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_PSORI_ACRODERM – Acrodermatitis continua

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acrodermatitis continua

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints