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Other drug-induced secondary parkinsonism

EFO Endpoint Browser PheWeb

OTHER_DRUGADVERS_SECONDA_PARKINSONI

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G21.1#

1 out of 7 registries used, show all original rules.

424

4. Check minimum number of events

None

424

5. Include endpoints

None

424

6. Filter based on genotype QC (FinnGen only)

361

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2777 1626 1117
Only index persons 2288 1355 933
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.04 0.05 0.04
Median age at first event (years)
Whole population 68.05 69.66 65.61
Only index persons 67.29 68.87 64.99

-FinnGen-

Key figures

All Female Male
Number of individuals 361 192 169
Unadjusted period prevalence (%) 0.07 0.07 0.08
Median age at first event (years) 64.17 65.17 63.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
369
Matched controls
3690
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N05AH03
ATC
olanzapine; systemic
60.0
307.7
240
111
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
94.4
307.7
277
114
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
+∞
307.7
369
*
N04AA02
ATC
biperiden; systemic
70.3
233.7
132
29
N05AX08
ATC
risperidone; systemic
25.2
223.0
206
176
N05AA02
ATC
levomepromazine; systemic
35.2
215.1
152
72
N05AX12
ATC
aripiprazole; systemic
46.7
214.8
135
45
N03AG01
ATC
valproic acid; systemic, rectal
25.0
192.4
161
111
N05AH04
ATC
quetiapine; oral
19.8
192.0
260
397
N05AN01
ATC
lithium; oral
52.2
180.9
108
29
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
60.1
175.6
101
23
N05AB03
ATC
perphenazine; systemic, rectal
30.0
163.5
118
57
N05AF03
ATC
chlorprothixene; systemic
34.7
143.6
96
37
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
53.5
136.7
80
19
F20.9
ICD-10 Finland
Schizophrenia, unspecified
38.8
128.4
82
27
N05BA06
ATC
lorazepam; systemic, sublingual
15.6
126.8
131
126
F29
ICD-10 Finland
Unspecified nonorganic psychosis
23.9
121.6
94
52
R25.1
ICD-10 Finland
Tremor, unspecified
21.8
106.5
85
50
P72
ICPC
Schizophrenia
25.0
98.5
73
36
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
58.6
96.6
55
11
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
57.3
94.5
54
11
N05AD01
ATC
haloperidol; systemic
21.1
93.7
75
44
N05AH02
ATC
clozapine; systemic
31.6
90.7
61
23
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
26.0
87.0
63
29
N05AC02
ATC
thioridazine; oral
27.9
86.8
61
26
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
35.4
80.6
52
17
N05AA01
ATC
chlorpromazine; systemic, rectal
30.0
79.2
54
21
N05CD07
ATC
temazepam; oral
7.9
77.9
143
275
N05BA04
ATC
oxazepam; oral
6.6
73.9
217
653
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
31.5
70.4
47
17
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
31.5
70.4
47
17
P99
ICPC
Psychological disorders other
16.8
68.9
61
43
P29
ICPC
Psychological sympt/compl other
10.0
68.2
89
114
F31
ICD-10 Finland
Bipolar affective disorder
37.3
67.9
43
13
G20
ICD-10 Finland
Parkinson disease
14.4
65.0
63
52
N05BA01
ATC
diazepam; systemic, rectal
6.1
59.0
138
328
T36
ICD-10 Finland
Poisoning by systemic antibiotics
12.0
58.0
63
62
N06AB04
ATC
citalopram; systemic
5.3
54.7
173
529
N03AX09
ATC
lamotrigine; oral
10.8
52.8
62
68
F22.0
ICD-10 Finland
Delusional disorder
21.2
51.7
40
21
SPAT1234
SPAT
Support of social functional capacity
9.8
48.6
61
73
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
13.0
47.4
48
42
N05BE01
ATC
buspirone; oral
11.0
45.9
52
54
F31.8
ICD-10 Finland
Other bipolar affective disorders
18.9
44.2
36
21
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
70.3
43.4
49
8
C07AA05
ATC
propranolol; systemic
4.5
42.8
150
483
SPAT1240
SPAT
Therapeutic discussion
6.3
42.4
82
159
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
13.0
41.9
42
36
N03AE01
ATC
clonazepam; systemic
7.3
41.5
68
111
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
10.8
41.2
47
49
IGY02
NOMESCO Finland
Psychiatric monitoring contact
13.1
41.0
41
35
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
14.0
39.8
38
30
N05AL01
ATC
sulpiride; systemic
16.9
39.6
34
22
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
12.0
38.0
40
37
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
16.4
37.8
33
22
N05AF01
ATC
flupentixol; systemic
14.2
37.1
35
27
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.1
36.8
93
228
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
6.1
36.8
73
144
N06AB06
ATC
sertraline; oral
5.1
36.7
92
224
N06AX16
ATC
venlafaxine; oral
4.6
36.4
112
322
N06AX03
ATC
mianserin; oral
7.3
35.7
57
90
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.1
34.2
85
205
N06AG02
ATC
moclobemide; oral
7.5
34.2
53
81
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
7.7
34.0
51
75
L28
ICPC
Limited function/disability (L)
4.0
34.0
139
489
SPAT1222
SPAT
Counselling/guidance promoting independent living
4.3
33.7
114
350
A28
ICPC
Limited function/disability NOS
3.9
33.3
135
471
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
44.6
32.9
40
10
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.9
32.6
136
483
N05CF01
ATC
zopiclone; oral
3.5
31.9
200
923
A06AD11
ATC
lactulose; oral
4.1
31.8
112
353
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
36.1
30.7
39
12
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
33.3
30.1
39
13
R53
ICD-10 Finland
Malaise and fatigue
3.5
29.5
155
634
U04
ICPC
Incontinence urine
5.8
29.3
59
117
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.9
28.9
57
111
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
8.5
28.2
38
49
SPAT1254
SPAT
Administration of medicine
4.0
27.8
98
306
ZY010
NOMESCO Finland
Hospital outpatient
6.8
27.4
46
76
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
8.2
27.2
38
51
N06AX11
ATC
mirtazapine; oral
3.2
26.6
193
945
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
7.1
26.2
42
66
SPAT1216
SPAT
Assessment of functional ability
3.7
26.2
105
357
N05AF05
ATC
zuclopenthixol; systemic
36.1
26.0
33
10
188
Kela drug reimbursment
Psychosis requiring demanding treatment
46.5
25.0
30
7
AA1AD
NOMESCO Finland
CT of head and brain
3.1
24.6
172
815
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.1
24.6
155
693
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
9.1
24.4
31
37
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
5.4
24.2
52
109
N06AA12
ATC
doxepin; systemic
5.1
24.0
55
122
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.8
23.8
59
140
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
6.2
23.1
42
75
N06AB03
ATC
fluoxetine; oral
3.7
22.9
88
289
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
6.0
22.7
43
80
K59.0
ICD-10 Finland
Constipation
4.9
22.6
54
124
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
55.7
22.4
26
5
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.6
22.1
86
284
G25.1
ICD-10 Finland
Drug-induced tremor
233.3
21.8
22
*
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
46.4
21.7
26
6
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
36.3
21.4
27
8
F31.3
ICD-10 Finland
Bipolar affective disorder, current episode mild or moderate depression
39.8
21.1
26
7
N03AF01
ATC
carbamazepine; oral, rectal
4.9
21.1
50
114
F31.5
ICD-10 Finland
Bipolar affective disorder, current episode severe depression with psychotic symptoms
222.0
20.8
21
*
SPAT1307
SPAT
Psychosocial counselling and guidance
6.7
20.6
34
55
P98
ICPC
Psychosis NOS/other
51.1
20.4
24
5
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
61.1
20.1
23
*
F20.5
ICD-10 Finland
Residual schizophrenia
30.9
19.9
26
9
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
5.5
19.5
40
80
N07BB01
ATC
disulfiram; oral
5.4
19.5
41
84
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.7
19.4
48
113
F10.20
ICD-10 Finland
Alcohol dependence currently independent
8.6
19.0
25
31
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
4.3
18.9
53
138
A04
ICPC
Weakness/tiredness general
3.2
18.6
88
326
IHZ05, ,
SPAT
7.1
18.6
29
44
AA400
NOMESCO Finland
Electroconvulsive therapy
46.6
18.4
22
5
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.6
18.3
68
216
29580
ICD-8 Finland
Schizophrenia, Other
55.5
18.1
21
*
P76
ICPC
Depressive disorder
4.8
17.8
43
99
N05BA12
ATC
alprazolam; oral
3.6
17.8
68
220
EBA30
NOMESCO Finland
Extraction of root of tooth
4.3
17.6
50
131
IGY02, ,
SPAT
22.2
17.5
25
12
N06AB05
ATC
paroxetine; oral
4.7
17.4
43
101
R32
ICD-10 Finland
Unspecified urinary incontinence
6.3
17.3
30
51
N05AE04
ATC
ziprasidone; systemic
33.3
17.2
22
7
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
19.0
16.7
25
14
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
21.3
16.6
24
12
IGY99
NOMESCO Finland
Other psychiatric treatment contact
15.2
16.6
27
19
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.2
16.6
47
123
F03
ICD-10 Finland
Unspecified dementia
5.4
16.5
34
68
F31.31
ICD-10 Finland
Bipolar disorder depressive episode with somatic syndrome
42.2
16.5
20
5
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
16.4
16.4
26
17
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
16.2
161
871
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
6.5
16.2
27
44
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.7
16.2
40
94
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.6
16.1
59
185
K08.3
ICD-10 Finland
Retained dental root
3.7
15.9
55
166
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
4.8
15.6
37
84
F05.9
ICD-10 Finland
Delirium, unspecified
7.4
15.4
23
33
AA5EN
NOMESCO Finland
Brain reseptor or transprot protein distribution isotope imaging
30.1
15.3
20
7
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.9
15.3
49
140
2989X
ICD-9 Finland
Other nonorganic psychoses, Unspecified psychosis
24.6
15.3
21
9
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
3.0
15.3
77
294
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.5
15.2
140
727
F31.2
ICD-10 Finland
Bipolar affective disorder, current episode manic with psychotic symptoms
47.1
15.2
18
*
N06AX12
ATC
bupropion; oral
4.6
15.2
38
90
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
3.0
15.1
79
308
SPAT1301
SPAT
No procedures
2.5
15.1
149
799
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
5.9
15.0
28
51
F20.0
ICD-10 Finland
Paranoid schizophrenia
33.3
14.9
19
6
F20.04
ICD-10 Finland
Paranoid schizophrenia with partial recurrence
22.2
14.8
21
10
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
12.6
14.8
26
22
N29
ICPC
Neurological sympt/complt other
11.6
14.8
27
25
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.2
14.7
66
235
N06AA06
ATC
trimipramine; systemic
5.7
14.7
28
52
R41.0
ICD-10 Finland
Disorientation, unspecified
5.4
14.6
30
60
F21
ICD-10 Finland
Schizotypal disorder
37.7
14.6
18
5
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
17.9
14.5
22
13
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.8
14.4
87
366
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
12.7
14.3
25
21
N05AD03
ATC
melperone; systemic
15.2
14.2
23
16
F22.9
ICD-10 Finland
Persistent delusional disorder, unspecified
44.4
14.2
17
*
ZYC01
NOMESCO Finland
Remote contact by phone
3.9
14.1
45
128
N05AX13
ATC
paliperidone; systemic
24.9
13.9
19
8
29570
ICD-8 Finland
Schizophrenia, Schizo-affective type
55.6
13.9
16
*
SPAT1215
SPAT
Assessment of need for medical rehabilitation
5.2
13.8
29
59
N30.0
ICD-10 Finland
Acute cystitis
2.7
13.7
86
368
SPAT1172
SPAT
Guidance concerning hydration
10.7
13.7
26
26
EBA00
NOMESCO Finland
Extraction of tooth
2.3
13.7
163
940
F61.0
ICD-10 Finland
Mixed personality disorders
13.5
13.6
23
18
F41.1
ICD-10 Finland
Generalized anxiety disorder
4.7
13.4
32
73
G25.0
ICD-10 Finland
Essential tremor
5.2
13.3
28
57
SPAT1229
SPAT
Assessment of need for aid
3.5
13.3
49
154
P03
ICPC
Feeling depressed
3.6
13.3
48
149
N06AA04
ATC
clomipramine; systemic
10.6
13.2
25
25
SPAT1167
SPAT
Insertion of urinary catheter
5.5
13.2
26
50
C03CA01
ATC
furosemide; systemic
2.3
13.1
154
879
29999
ICD-8 Finland
Unspecified psychosis
23.6
13.0
18
8
R42
ICD-10 Finland
Dizziness and giddiness
2.4
13.0
120
617
N06AX05
ATC
trazodone; oral
5.6
13.0
25
47
P20
ICPC
Memory disturbance
2.7
12.8
81
347
P01
ICPC
Feeling anxious/nervous/tense
3.3
12.7
51
169
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
4.3
12.7
34
85
P28
ICPC
Limited function/disability (P)
33.3
12.7
16
5
I95.1
ICD-10 Finland
Orthostatic hypotension
4.8
12.6
29
64
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.8
12.6
29
64
F34.1
ICD-10 Finland
Dysthymia
4.5
12.5
32
77
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.1
12.5
36
95
G72.8
ICD-10 Finland
Other specified myopathies
9.5
12.4
25
28
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
3.8
12.4
39
110
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.3
12.2
128
692
SPAT1241
SPAT
Extensive assessment of psychosocial situation
22.2
12.1
17
8
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
12.0
63
244
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
3.1
12.0
56
203
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
5.6
12.0
23
43
T90
ICPC
Diabetes non-insulin dependent
2.3
12.0
129
705
29599
ICD-8 Finland
Schizophrenia, Unspecified type
48.3
12.0
14
*
N05CD02
ATC
nitrazepam; oral
5.8
11.8
22
40
IGV01
NOMESCO Finland
Psychiatric network contact
17.1
11.8
18
11
IGY99, ,
SPAT
17.1
11.8
18
11
SPAT1252
SPAT
Overall medication plan or its review
3.5
11.8
42
129
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.5
11.8
42
129
D12
ICPC
Constipation
4.1
11.8
34
90
2957A
ICD-9 Finland
Schizophrenic psychoses, Schizo-affective type
31.2
11.7
15
5
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.3
11.5
47
157
F25.2
ICD-10 Finland
Schizoaffective disorder, mixed type
+∞
11.5
11
*
F25
ICD-10 Finland
Schizoaffective disorders
+∞
11.5
11
*
G21.0
ICD-10 Finland
Malignant neuroleptic syndrome
123.7
11.5
12
*
F25.21
ICD-10 Finland
Schizoaffective syndrome, mixed type with prolonged schizophrenic than bipolar symptoms
123.7
11.5
12
*
S72.0
ICD-10 Finland
Fracture of neck of femur
4.6
11.4
28
65
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
11.4
78
347
P73
ICPC
Affective psychosis
36.3
11.3
14
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.4
11.3
29
70
SPAT1243
SPAT
Psychiatric/psychological examination
8.5
11.3
24
30
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
20.8
11.2
16
8
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
20.8
11.2
16
8
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
26.0
11.2
15
6
SPAT1360
SPAT
Extensive global examination
3.5
11.0
40
124
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.7
11.0
37
109
30041
ICD-8 Finland
Neuroses, Depressiva
12.4
11.0
19
16
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
10.0
10.9
21
22
N06AB08
ATC
fluvoxamine; oral
4.8
10.9
25
55
P27
ICPC
Fear of mental disorder
18.5
10.8
16
9
A46
ICD-10 Finland
Erysipelas
2.5
10.8
78
355
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
10.8
65
271
ZY000
NOMESCO Finland
Hospital inpatient
13.4
10.8
18
14
K59.09
ICD-10 Finland
Constipation, unspecified
3.1
10.5
47
166
F20.08
ICD-10 Finland
Paranoid schizophrenia other definite
113.1
10.5
11
*
N05AE05
ATC
lurasidone; oral
113.1
10.5
11
*
97010
ICD-8 Finland
Adverse effect of psychotherapeutics, Tranquillisers
113.1
10.5
11
*
N06AX26
ATC
vortioxetine; oral
3.5
10.5
38
118
P74
ICPC
Anxiety disorder/anxiety state
4.6
10.4
25
57
R60.0
ICD-10 Finland
Localized oedema
2.5
10.4
72
321
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
11.1
10.4
19
18
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.2
10.4
126
716
ICB01, ,
SPAT
19.5
10.3
15
8
SPAT1053
SPAT
Memory test
2.5
10.3
71
316
N06AA09
ATC
amitriptyline; systemic
2.8
10.3
55
215
A10BA02
ATC
metformin; oral
2.1
10.2
139
825
F20
ICD-10 Finland
Schizophrenia
15.1
10.1
16
11
F23.90
ICD-10 Finland
Acute and transient psychosis, unspecified without acute stress factor
41.3
10.0
12
*
29540
ICD-8 Finland
Acute schizophrenia episode
41.3
10.0
12
*
F25.01
ICD-10 Finland
Schizoaffective syndrome, manic type with prolonged schizophrenic than bipolar symptoms
41.3
10.0
12
*
K03.66
ICD-10 Finland
Tooth plaque
3.1
9.9
43
149
S01.0
ICD-10 Finland
Open wound of scalp
3.0
9.9
46
166
N28
ICPC
Limited function/disability (N)
9.1
9.9
20
23
N05AC01
ATC
periciazine; systemic
26.9
9.9
13
5
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
20.7
9.9
14
7
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.9
9.8
51
196
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.6
9.8
64
277
IEY02
NOMESCO Finland
Intensified psychiatric outpatient care, Assertive Community Treatment (ACT)
56.5
9.7
11
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
9.5
9.6
19
21
N06AX22
ATC
agomelatine; oral
7.9
9.6
21
28
N06AB10
ATC
escitalopram; oral
2.3
9.5
85
425
G25.2
ICD-10 Finland
Other specified forms of tremor
12.8
9.4
16
13
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
5.1
9.4
20
41
2962E
ICD-9 Finland
Affective psychoses, Major depressive disorder, single episode[PSYCH.BIPOLARIS MANICA,VAIKEA-ASTE,PSYKOOT PIIRTEIT]
+∞
9.4
9
*
N30.9
ICD-10 Finland
Cystitis, unspecified
3.2
9.4
39
132
H03AA01
ATC
levothyroxine sodium; systemic
2.2
9.3
104
568
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
9.3
81
400
Z2446
NOMESCO Finland
Social worker
3.2
9.2
39
133
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
9.2
67
305
U07
ICPC
Urine symptom/complaint other
2.8
9.2
50
197
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
11.9
9.2
16
14
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
9.1
125
737
ICB03, ,
SPAT
37.7
9.1
11
*
ZXY01
NOMESCO Finland
Chief Physician, Head of Department or Deputy Chief Physician
37.7
9.1
11
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
7.1
9.0
21
31
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
24.7
9.0
12
5
L17
ICPC
Foot/toe symptom/complaint
2.0
8.9
137
840
N99
ICPC
Neurological disease other
13.0
8.9
15
12
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
13.0
8.9
15
12
IHZ04, ,
SPAT
11.1
8.9
16
15
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
3.4
8.8
32
99
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
6.9
8.8
21
32
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
4.4
8.8
22
52
103
Kela drug reimbursment
Diabetes, insulin-treated
2.0
8.8
128
771
F30.20
ICD-10 Finland
Mania with mood-congruent psychotic symptoms
51.2
8.7
10
*
IBZ07
NOMESCO Finland
Neurological assessment in psychiatry
51.2
8.7
10
*
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
16.8
8.6
13
8
SPAT1310
SPAT
Counselling related to known health issue
2.0
8.6
134
825
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.5
8.5
30
91
N17
ICPC
Vertigo/dizziness
2.4
8.5
64
295
IER01
NOMESCO Finland
Psychoeducation, group
28.3
8.5
11
*
F23.3
ICD-10 Finland
Other acute predominantly delusional psychotic disorders
20.6
8.5
12
6
N87
ICPC
Parkinsonism
8.2
8.5
18
23
A69
ICPC
General and Unspecified, Other reason for encounter NEC
5.1
8.4
18
37
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
92.1
8.4
9
*
IEV99
NOMESCO Finland
Other psychiatric network intervention
92.1
8.4
9
*
G21.8
ICD-10 Finland
Other secondary parkinsonism
92.1
8.4
9
*
TKC20
NOMESCO Finland
Catheterisation of bladder
3.0
8.4
40
146
K02.1
ICD-10 Finland
Caries of dentine
1.9
8.4
224
1644
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.2
8.4
86
453
F60.9
ICD-10 Finland
Personality disorder, unspecified
11.1
8.4
15
14
F23.91
ICD-10 Finland
Acute and transient psychosis, unspecified without acute stress factor
+∞
8.4
8
*
F23.9
ICD-10 Finland
Acute and transient psychotic disorder, unspecified
+∞
8.4
8
*
F33.31
ICD-10 Finland
Recurrent depression, severe episode of somatic syndrome
+∞
8.4
8
*
Z2445
NOMESCO Finland
Psychologist
4.1
8.3
23
59
IHZ07, ,
SPAT
17.7
8.1
12
7
IFA01, ,
SPAT
34.2
8.1
10
*
F23.99
ICD-10 Finland
Acute and transient psychosis, unspecified UNS
34.2
8.1
10
*
F25.1
ICD-10 Finland
Schizoaffective disorder, depressive type
34.2
8.1
10
*
A29
ICPC
General symptom/complaint other
2.3
8.0
69
337
J01EA01
ATC
trimethoprim; systemic
2.0
8.0
109
638
30188
ICD-8 Finland
Personality disorders, Alia definita
13.4
7.9
13
10
L75
ICPC
Fracture: femur
13.4
7.9
13
10
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
7.9
37
848
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
7.9
117
705
W19
ICD-10 Finland
Unspecified fall
2.6
7.8
49
207
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.0
7.8
22
57
F41.09
ICD-10 Finland
UNS Panic Syndrome
6.6
7.8
19
30
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
7.7
7.8
17
23
2959C
ICD-9 Finland
Schizophrenic psychoses, Unspecified schizophrenia[ERILAISTUMATON SKITSOFRENIA,KROONINEN]
46.0
7.7
9
*
F30.9
ICD-10 Finland
Manic episode, unspecified
46.0
7.7
9
*
IEY08
NOMESCO Finland
Psychiatric coaching, domestic and community skills
46.0
7.7
9
*
IFA99, ,
SPAT
46.0
7.7
9
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
7.7
126
782
OAB43, ,
SPAT
0.2
7.7
10
470
29530
ICD-8 Finland
Schizophrenia, Paranoid type
18.8
7.6
11
6
P17
ICPC
Tobacco abuse
9.1
7.6
15
17
IGP01
NOMESCO Finland
Psychiatric family contact
25.6
7.6
10
*
F25.0
ICD-10 Finland
Schizoaffective disorder, manic type
25.6
7.6
10
*
F20.8
ICD-10 Finland
Other schizophrenia
25.6
7.6
10
*
G04BD12
ATC
mirabegron; oral
2.3
7.6
65
317
SPAT1081
SPAT
Cardiorespiratory global assessment
3.2
7.5
31
104
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.2
7.5
30
99
S97
ICPC
Chronic ulcer skin
2.7
7.5
41
162
SPAT1139
SPAT
Nutrition survey
4.2
7.4
20
50
D01AC02
ATC
miconazole; topical
2.7
7.4
41
163
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.4
7.4
53
239
F41.3
ICD-10 Finland
Other mixed anxiety disorders
9.7
7.3
14
15
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.3
7.3
28
90
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
4.5
7.3
18
42
R33
ICD-10 Finland
Retention of urine
2.6
7.3
45
189
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
7.5
7.3
16
22
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.7
7.3
23
65
D11
ICPC
Diarrhoea
2.4
7.2
54
248
IAB01, ,
SPAT
20.5
7.2
10
5
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
20.5
7.2
10
5
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
20.5
7.2
10
5
F61
ICD-10 Finland
Mixed and other personality disorders
20.5
7.2
10
5
30000
ICD-8 Finland
Neuroses, Anxiety neurosis
12.4
7.1
12
10
R41.3
ICD-10 Finland
Other amnesia
4.0
7.1
20
52
G04BD08
ATC
solifenacin; oral
2.7
7.0
38
149
E86
ICD-10 Finland
Volume depletion
5.7
7.0
19
35
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
6.0
7.0
18
31
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
6.9
177
1255
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.4
6.8
24
73
P50
ICPC
Psychological, Medication/prescr/renewal
17.1
6.8
10
6
F13.29
ICD-10 Finland
Addiction caused by sedative and hypnotic UNS
17.1
6.8
10
6
F20.10
ICD-10 Finland
Raise schizophrenia continuously
17.1
6.8
10
6
29830
ICD-8 Finland
Other psychoses, Acute paranoid reaction
17.1
6.8
10
6
R50.9
ICD-10 Finland
Fever, unspecified
2.1
6.8
70
368
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
6.7
40
165
F20.34
ICD-10 Finland
Undifferentiated schizophrenia with partial recurrence
23.0
6.7
9
*
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
23.0
6.7
9
*
A08
ICPC
Swelling
2.8
6.7
34
129
SPAT1251
SPAT
Organisation of medication
3.5
6.7
23
69
N06AX21
ATC
duloxetine; oral
2.3
6.6
56
271
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.9
6.6
97
578
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.2
6.6
64
328
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.5
6.5
43
186
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.5
6.5
22
65
SFA30
NOMESCO Finland
Three-surface restoration
1.8
6.5
172
1226
A03
ICPC
Fever
2.1
6.5
63
323
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
7.6
6.5
14
19
ZXY03
NOMESCO Finland
Occupational therapist
71.0
6.4
7
*
F28
ICD-10 Finland
Other nonorganic psychotic disorders
71.0
6.4
7
*
29510
ICD-8 Finland
Schizophrenia, Hebephrenic type
71.0
6.4
7
*
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
71.0
6.4
7
*
2959A
ICD-9 Finland
Schizophrenic psychoses, Unspecified schizophrenia[ERILAISTUMATON SKITSOFRENIA,TARKEMMIN MÄÄRITTELEMÄT]
71.0
6.4
7
*
2961C
ICD-9 Finland
Affective psychoses, Manic disorder, recurrent episode[VAKAVA MASENNUSTILA,KESKIVAIKEA]
14.6
6.4
10
7
N05AB01
ATC
dixyrazine; systemic
6.7
6.4
15
23
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.8
6.3
118
757
29630
ICD-8 Finland
Affective psychoses, Manic-depressive psychosis, circular type
+∞
6.3
6
*
F23.29
ICD-10 Finland
Acute schizophrenia-like psychosis UNS
+∞
6.3
6
*
2953E
ICD-9 Finland
Schizophrenic psychoses, Paranoid type[PARANOIDISTYYPPINEN SKITSOFRENIA,KROONINEN AKUUTTI]
27.2
6.3
8
*
30310
ICD-8 Finland
Alcoholism, Habitual excessive drinking
27.2
6.3
8
*
ZXY60
NOMESCO Finland
2-person team, nurses
27.2
6.3
8
*
ICC03
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric ward
27.2
6.3
8
*
F20.39
ICD-10 Finland
Undifferentiated schizophrenia UNS
27.2
6.3
8
*
K59.1
ICD-10 Finland
Functional diarrhoea
2.8
6.2
32
122
SPAT1101
SPAT
Orthostatic test
3.4
6.2
22
67
SPAT1294
SPAT
Other function in accordance with health social work nomenclature
4.2
6.1
16
39
UKC02
NOMESCO Finland
Cystoscopy
2.0
6.1
70
381
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
6.1
77
434
L84
ICD-10 Finland
Corns and callosities
3.5
6.1
21
63
F32.1
ICD-10 Finland
Moderate depressive episode
3.1
6.1
25
84

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
66
11
72.85
120.50
18.0
14.1
0.65
0.69
mmol/l
0.34
61
11
162
589
4.12
38.53
2.4
1.7
1232.61
1231.33
nmol/l
0.01
124
445
205
1095
2.96
23.26
3.8
2.2
698.43
246.42
u/l
0.81
196
1031
199
1058
2.91
22.58
5.5
3.3
—
—
—
0
0
193
1035
2.81
21.15
2.2
1.7
19.85
20.47
nmol/l
0.22
162
857
273
1766
3.10
20.74
8.3
8.0
1.23
1.21
mmol/l
3.64
242
1526
257
1612
2.96
20.62
7.3
7.1
1.23
1.21
mmol/l
2.12
244
1482
185
996
2.72
19.74
5.6
4.5
—
—
—
0
0
248
1558
2.80
19.26
5.0
5.2
34.37
35.47
g/l
2.23
235
1476
245
1556
2.71
18.16
3.2
2.1
97.38
96.92
pmol/l
0.05
146
775
204
1194
2.58
17.78
3.7
3.7
2.36
2.36
mmol/l
0.01
181
1076
300
2171
3.04
16.26
9.4
4.8
1428.33
1975.62
e6/l
—
6
39
194
1143
2.47
16.20
2.9
2.7
48.94
65.32
u/l
2.26
174
1053
151
835
2.37
14.03
2.6
2.2
3.00
3.12
mg/l
0.25
128
724
266
1893
2.45
13.44
17.2
10.4
4.19
4.10
e9/l
0.30
234
1647
132
702
2.37
13.28
2.0
1.8
469.63
20455001.94
pmol/l
0.50
107
572
245
1699
2.32
12.89
8.6
6.3
0.62
0.59
e9/l
1.20
208
1441
245
1707
2.30
12.63
8.7
6.3
0.04
0.04
e9/l
1.31
207
1448
247
1729
2.30
12.55
8.9
6.3
1.83
1.91
e9/l
0.42
214
1510
25
28
9.49
12.45
2.2
1.2
—
—
—
0
0
249
1757
2.28
12.29
9.5
6.5
0.19
0.19
e9/l
0.20
213
1522
30
72
4.45
11.77
1.3
1.3
1.67
13.07
e6/l
0.63
21
55
61
238
2.87
11.48
5.0
3.4
7.41
7.42
ph
1.10
54
198
183
1167
2.13
11.37
3.6
3.4
28.11
33.76
u/l
1.56
170
1095
30
74
4.32
11.37
1.3
1.4
17.23
169.43
e6/l
1.02
22
58
180
1147
2.11
11.14
7.2
6.2
—
—
—
0
0
210
1426
2.10
10.87
5.0
3.7
6.52
6.19
ph
3.29
97
790
272
2040
2.27
10.87
7.8
5.5
6.90
6.76
mmol/l
0.41
265
1944
220
1523
2.10
10.78
3.1
2.5
76.39
78.74
nmol/l
0.58
199
1351
292
2259
2.40
10.78
7.9
4.8
—
2.91
—
0
5
66
278
2.67
10.71
3.0
3.8
90.59
81.68
ng/l
0.24
49
244
311
2484
2.60
10.54
6.9
4.2
14.88
14.91
pmol/l
0.07
283
2245
161
1001
2.08
10.46
6.9
4.2
0.00
0.02
estimate
0.78
44
326
93
466
2.33
10.40
3.8
5.9
0.99
1.02
mmol/l
0.59
85
435
26
63
4.36
10.07
2.4
1.2
—
—
—
0
0
222
1571
2.04
9.90
8.0
6.4
2.58
2.85
%
0.96
210
1474
223
1581
2.04
9.89
7.9
6.3
57.96
57.68
%
0.13
211
1509
26
64
4.29
9.87
2.4
1.2
—
—
—
0
0
25
60
4.40
9.80
1.2
1.3
—
—
—
0
0
222
1575
2.03
9.78
8.2
6.5
8.89
8.96
%
0.11
209
1483
224
1597
2.02
9.70
8.1
6.5
26.51
27.03
%
0.28
214
1516
72
334
2.44
9.51
2.4
2.2
0.00
0.05
estimate
0.49
13
64
26
66
4.16
9.49
2.4
1.2
—
—
—
0
0
26
66
4.16
9.49
2.4
1.2
—
—
—
0
0
316
2593
2.52
9.21
9.2
8.9
82.67
80.71
u/l
0.31
304
2451
219
1567
1.98
9.18
8.3
6.5
0.60
0.70
%
2.24
207
1468
109
611
2.11
9.12
2.1
3.6
0.83
0.82
mmol/l
0.20
100
582
241
1788
2.00
9.03
6.4
4.1
0.31
4.54
estimate
0.45
48
358
166
1087
1.96
8.97
4.3
4.2
7.40
7.40
ph
0.15
125
768
45
170
2.88
8.93
2.5
2.5
0.00
0.02
estimate
—
9
55
17
18
9.84
8.87
4.6
2.0
—
—
—
0
0
69
330
2.34
8.47
6.0
4.3
7.34
7.35
ph
0.16
53
237
247
1879
1.95
8.23
5.4
7.3
8.89
11.98
umol/l
7.60
236
1788
99
554
2.08
8.22
2.2
2.4
2.34
2.32
g/l
0.14
79
513
63
294
2.38
8.16
2.1
2.9
66.00
67.05
g/l
0.54
46
275
236
1772
1.92
8.13
6.2
4.1
0.00
0.00
estimate
-0.00
47
346
21
51
4.31
8.11
2.3
1.2
—
—
—
0
0
171
1174
1.85
7.65
3.5
3.3
1157.67
1130.41
ng/l
0.05
150
997
11
6
18.84
7.64
2.6
1.7
15.30
21.88
umol/l
—
11
6
238
1812
1.88
7.63
6.4
4.1
0.04
0.91
estimate
0.47
45
330
102
592
2.00
7.59
2.3
2.4
11.11
12.87
umol/l
1.85
86
552
24
69
3.65
7.40
1.3
1.4
50.88
59.26
mmol/l
0.42
17
62
42
169
2.68
7.39
4.6
3.6
—
—
—
0
0
116
711
1.92
7.34
3.5
3.0
2.48
2.45
mmol/l
2.15
105
643
23
67
3.59
6.96
2.6
1.2
—
—
—
0
0
11
8
14.12
6.93
1.8
1.1
—
—
—
0
0
70
1200
0.49
6.92
3.6
3.5
—
—
—
0
0
65
330
2.18
6.86
2.4
2.0
421.14
381.21
nmol/l
0.69
57
310
37
145
2.72
6.85
1.9
2.0
1.33
3.73
ug/l
0.59
29
132
49
221
2.40
6.81
4.8
6.8
—
—
—
0
0
165
1154
1.78
6.70
4.8
3.3
26.69
107.53
e6/l
0.80
129
880
192
1405
1.76
6.65
7.1
3.9
22.97
73.37
ng/l
0.74
168
1065
60
299
2.20
6.62
3.0
2.5
5.70
7.29
ug/l
0.46
46
271
56
272
2.25
6.57
3.8
3.5
—
—
—
0
0
107
661
1.87
6.50
3.9
2.9
413.81
531.26
mosm/kgh2o
8.29
89
577
37
151
2.61
6.34
1.6
1.5
0.12
0.41
mg/l
3.62
11
68
34
133
2.71
6.32
2.1
3.6
48.85
44.10
mg/l
0.10
28
116
34
133
2.71
6.32
2.1
3.6
41.67
93.48
mg/l
0.59
28
114
266
2162
1.83
6.21
5.8
3.4
53.35
54.99
u/l
0.07
247
2010
121
787
1.80
6.18
3.7
2.6
6.22
4.63
e6/l
0.95
111
718
53
259
2.22
6.12
2.2
2.4
—
—
—
0
0
32
124
2.73
6.06
5.0
2.4
25.68
25.10
mmol/l
0.31
32
124
77
436
1.97
6.03
5.7
3.2
6.14
6.23
e9/l
0.01
51
378
17
45
3.91
5.88
2.2
1.6
293.83
273.91
mosm/kgh2o
1.09
12
33
77
440
1.95
5.87
1.8
2.8
1.82
1.86
%
0.12
64
407
15
27
5.74
5.74
1.0
1.1
—
—
—
0
0
87
524
1.86
5.64
2.3
2.4
19.31
21.92
%
1.25
71
495
16
32
5.18
5.63
1.1
1.0
810.60
635.00
ng/l
—
10
19
16
32
5.18
5.63
1.1
1.0
222.18
295.50
ng/l
0.72
11
18
77
446
1.92
5.62
5.4
10.1
2.67
0.96
mmol/l
1.99
64
377
16
44
3.76
5.26
3.1
1.2
—
—
—
0
0
76
450
1.87
5.17
5.5
10.1
7.40
7.41
ph
0.54
41
252
15
33
4.69
4.92
1.1
1.4
—
—
—
0
0
138
981
1.65
4.91
4.9
3.3
0.31
0.44
e6/l
0.67
103
711
172
1292
1.62
4.90
5.9
4.0
95.78
108.82
e6/l
0.13
129
913
115
780
1.69
4.89
7.1
4.4
1.02
1.02
kg/l
1.89
80
521
15
42
3.68
4.81
2.3
2.1
1.19
0.73
mmol/l
0.18
15
42
20
68
3.05
4.79
7.2
2.7
—
—
—
0
0
329
2958
2.04
4.44
9.9
5.4
1.83
1.98
mu/l
1.72
312
2686
35
165
2.24
4.41
2.2
3.4
3.92
4.45
pmol/l
2.55
27
143
167
1269
1.58
4.39
4.0
3.4
5.88
7.51
mmol/l
5.78
137
1050
17
56
3.13
4.29
2.9
2.6
11.24
10.86
pmol/l
0.04
17
56
59
342
1.86
4.26
1.8
3.0
72.30
71.51
e9/l
0.05
50
252
28
122
2.40
4.22
1.9
3.2
1.23
2.39
ratio
1.11
18
67
116
834
1.57
3.76
5.8
4.0
—
0.38
—
0
8
12
29
4.24
3.73
1.1
1.2
110.58
95.07
pmol/l
0.31
12
29
21
88
2.47
3.46
1.3
1.6
—
—
—
0
0
53
318
1.78
3.43
5.5
10.3
—
—
—
0
0
33
170
2.03
3.36
4.9
4.2
37.02
36.92
°c
0.54
33
170
205
1695
1.47
3.29
16.6
12.7
1.26
1.22
inr
0.53
176
1397
339
3146
1.95
3.17
30.7
17.4
27.80
24.63
mg/l
1.08
311
2618
160
1270
1.46
3.13
4.8
4.1
10.04
8.13
mg/mmol
0.20
101
775
58
369
1.68
3.05
3.5
3.7
7.39
7.39
ph
0.04
30
215
156
1239
1.45
3.01
4.1
3.5
52.21
46.41
mg/l
0.11
104
787
56
356
1.68
2.96
4.5
3.6
3.29
2.08
mmol/l
1.26
47
306
105
775
1.50
2.93
2.0
1.6
0.93
1.47
mg/l
2.39
87
621
175
1433
1.42
2.80
3.4
2.8
139.92
140.34
ug/l
0.01
157
1329
0
74
0.00
2.80
0.0
1.6
—
—
—
0
0
94
693
1.48
2.61
5.4
4.2
97.32
333.04
ng/l
1.76
78
584
44
272
1.70
2.58
5.3
3.6
1.25
1.23
mmol/l
1.00
38
231
30
165
1.89
2.58
1.5
2.1
1.60
1.57
g/l
0.06
24
148
5
7
7.22
2.55
1.2
1.1
—
—
—
0
0
163
1335
1.40
2.54
7.3
4.1
0.00
0.02
estimate
0.96
36
284
19
90
2.17
2.43
2.3
3.5
0.17
2.16
index
—
6
55
51
335
1.61
2.38
2.1
2.6
30.88
32.38
u/l
0.17
41
278
80
588
1.46
2.24
4.3
3.1
1.92
2.38
e6/l
0.32
42
295
16
75
2.18
2.11
5.6
13.3
10.81
11.21
mmol/l
0.14
16
68
16
75
2.18
2.11
5.6
13.3
105.62
105.35
mmol/l
0.08
16
68
15
70
2.19
2.01
1.7
1.8
2.12
4.54
iu/l
—
5
31
26
149
1.80
2.00
1.1
1.8
—
—
—
0
0
24
135
1.83
1.96
1.9
2.3
9.11
10.56
g/l
0.86
15
123
5
11
4.59
1.94
1.4
1.2
—
—
%
—
0
0
62
448
1.46
1.90
1.7
1.7
—
—
—
0
0
35
223
1.63
1.87
5.6
12.9
15.91
15.62
%
0.20
35
215
56
399
1.48
1.84
1.6
1.7
—
—
—
0
0
17
87
2.00
1.83
6.8
2.3
8.18
8.00
kpa
0.24
17
87
13
61
2.17
1.73
1.1
1.1
—
—
—
0
0
5
13
3.88
1.72
1.2
1.4
—
—
—
0
0
5
14
3.60
1.62
4.2
2.2
35.22
43.21
g/l
—
5
14
11
219
0.49
1.58
1.2
1.3
—
—
—
0
0
329
3128
1.48
1.54
8.3
5.6
6.25
6.05
mmol/l
1.94
304
2866
27
170
1.63
1.54
4.8
7.8
1.80
1.61
%
0.44
27
159
38
263
1.50
1.46
4.3
3.2
168.94
189.26
ng/l
0.16
33
240
24
149
1.65
1.45
4.9
8.6
1.02
0.90
%
0.89
24
138
24
150
1.64
1.42
2.4
2.0
—
—
—
0
0
20
319
0.61
1.38
1.3
1.5
—
—
—
0
0
6
23
2.63
1.37
1.3
1.6
—
—
—
0
0
5
17
2.97
1.36
3.2
1.2
—
—
—
0
0
5
17
2.97
1.36
1.0
1.1
179.00
137.76
nmol/l
—
5
17
63
486
1.36
1.35
1.3
1.2
—
—
—
0
0
53
398
1.39
1.34
2.2
2.3
90.18
132.99
ug/g
0.55
38
322
324
3090
1.40
1.30
10.1
7.0
40.62
39.93
mmol/mol
0.64
299
2891
41
297
1.43
1.27
5.3
4.7
0.38
0.53
%
0.48
16
100
43
315
1.41
1.26
3.7
2.8
4.63
4.32
kpa
0.42
43
306
54
412
1.36
1.25
1.8
3.0
5.30
8.13
umol/l
1.98
47
369
18
109
1.68
1.21
1.4
1.4
280.38
286.99
ug/g
—
8
60
40
292
1.41
1.20
5.4
4.8
0.00
0.13
%
2.64
12
91
170
1513
1.23
1.17
17.9
11.5
0.00
0.00
e9/l
0.40
125
1226
129
1115
1.24
1.17
2.3
2.5
—
—
—
0
0
8
39
2.07
1.16
1.6
2.7
—
—
—
0
0
120
1031
1.24
1.14
9.5
6.6
—
—
—
0
0
36
263
1.41
1.09
9.4
3.7
—
—
—
0
0
21
138
1.55
1.05
2.5
3.1
—
—
—
0
0
40
300
1.37
1.04
5.5
5.2
0.23
0.20
%
0.05
13
82
9
48
1.90
1.01
4.6
2.4
4.56
4.57
e9/l
—
9
48
9
158
0.56
1.01
1.1
1.1
—
—
—
0
0
5
23
2.19
0.98
1.4
2.0
58.20
131.20
ng/l
—
5
23
7
37
1.91
0.94
2.6
2.1
—
—
—
0
0
7
37
1.91
0.94
1.0
1.2
—
—
—
0
0
41
315
1.34
0.93
5.3
4.6
0.93
0.95
%
0.02
14
114
172
1559
1.19
0.93
2.6
2.8
—
—
estimate
—
0
0
33
250
1.35
0.83
1.2
1.2
—
—
—
0
0
8
47
1.72
0.81
1.3
2.4
33.75
32.34
pg
—
8
47
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
33
424
0.76
0.78
1.5
1.3
—
—
—
0
0
75
872
0.82
0.77
1.3
1.3
—
—
—
0
0
88
765
1.20
0.74
1.5
1.3
0.93
1.45
u/ml
0.71
16
199
5
26
1.94
0.71
3.2
2.5
508.60
468.77
ml
—
5
13
14
93
1.53
0.70
2.4
2.4
5.38
81.67
ug/min
—
8
51
7
41
1.72
0.70
1.4
4.2
—
—
—
0
0
7
42
1.68
0.68
1.0
1.1
—
—
—
0
0
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
54
639
0.82
0.66
1.4
1.3
30.42
36.13
iu/ml
0.15
16
199
83
728
1.18
0.64
8.5
5.0
—
—
—
0
0
23
173
1.35
0.63
1.2
1.2
23.46
118.22
u/ml
—
8
69
24
182
1.34
0.63
2.8
2.5
—
—
—
0
0
331
3226
1.25
0.63
28.9
15.3
—
—
—
0
0
11
71
1.57
0.62
4.5
2.4
53.18
59.00
%
0.54
11
71
52
438
1.22
0.61
1.3
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
4.08
—
0
6
6
37
1.63
0.56
1.0
1.4
31.82
31.22
ng/l
—
6
37
35
286
1.25
0.55
5.1
2.5
6.32
6.05
ph
1.37
28
197
9
60
1.51
0.54
1.1
1.5
—
—
—
0
0
9
60
1.51
0.54
1.1
1.5
—
—
—
0
0
9
60
1.51
0.54
1.1
1.5
—
—
—
0
0
9
60
1.51
0.54
1.1
1.5
—
—
—
0
0
6
39
1.55
0.53
1.3
1.5
65.50
60.76
%
—
6
29
313
3046
1.18
0.52
5.1
4.7
1.56
1.31
mmol/l
4.89
279
2773
21
163
1.31
0.49
1.2
1.3
—
—
—
0
0
24
297
0.79
0.46
2.5
2.3
11.53
14.16
nmol/l
1.00
17
268
103
943
1.13
0.45
6.6
3.5
0.00
0.09
estimate
0.52
39
282
54
472
1.17
0.45
1.5
1.5
—
—
—
0
0
8
56
1.44
0.43
1.0
1.0
—
—
—
0
0
63
704
0.87
0.41
3.1
3.2
0.79
0.77
ug/l
0.06
50
458
14
105
1.35
0.41
22.1
10.9
—
—
—
0
0
5
33
1.52
0.41
1.2
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
3.3
—
6.06
—
0
16
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
75.08
—
0
12
12
88
1.38
0.40
7.1
2.0
118.33
131.48
g/l
0.90
12
65
5
34
1.48
0.40
1.4
1.3
—
—
—
0
0
7
103
0.67
0.40
1.1
1.2
—
2.97
—
0
16
52
587
0.87
0.40
1.3
1.3
24.48
12.84
u/ml
0.21
13
230
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
27
322
0.83
0.39
1.4
1.6
—
—
—
0
0
11
80
1.39
0.39
1.5
1.2
—
—
—
0
0
5
36
1.39
0.38
1.2
1.5
37.68
30.83
g/l
—
5
31
8
113
0.70
0.37
1.0
1.2
—
91.54
—
0
13
16
125
1.29
0.37
4.3
3.4
422.86
208.88
mg/l
—
7
50
339
3338
1.19
0.37
18.2
13.3
25.53
26.72
u/l
0.38
333
3226
9
70
1.29
0.37
1.1
1.3
—
—
—
0
0
60
539
1.14
0.36
1.8
2.1
—
—
—
0
0
6
45
1.34
0.34
1.8
1.1
—
—
—
0
0
7
96
0.72
0.31
10.3
5.0
—
—
—
0
0
8
63
1.28
0.28
3.3
2.9
—
—
—
0
0
139
1457
0.93
0.27
2.0
2.0
1.59
1.35
mmol/l
2.09
116
1202
16
193
0.82
0.27
5.1
3.8
1.02
1.02
ratio
0.63
16
183
87
929
0.92
0.27
3.3
2.9
365.97
349.09
umol/l
0.93
69
806
37
331
1.13
0.25
1.6
1.5
—
—
—
0
0
10
78
1.29
0.24
1.2
1.2
—
—
—
0
0
5
39
1.29
0.23
1.0
1.1
1.67
1.48
nmol/l
—
5
34
127
1327
0.93
0.23
2.2
2.2
—
—
—
0
0
322
3178
1.10
0.22
6.2
5.6
4.21
4.61
mmol/l
10.46
291
2930
5
42
1.19
0.21
2.4
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
54.73
—
0
11
0
11
0.00
0.21
0.0
1.0
—
37.07
—
0
6
0
10
0.00
0.21
0.0
2.3
—
2.90
—
0
10
0
12
0.00
0.21
0.0
1.3
—
1.31
—
0
5
0
12
0.00
0.21
0.0
1.1
—
0.06
—
0
6
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
14
117
1.20
0.21
1.1
1.2
—
2.16
—
0
9
74
696
1.08
0.20
1.5
1.5
2.41
2.68
g/l
0.49
37
410
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.0
—
0.62
—
0
14
14
165
0.84
0.20
1.2
1.3
—
—
—
0
0
6
50
1.20
0.20
2.8
2.8
—
—
—
0
0
6
51
1.18
0.19
1.0
1.3
—
—
—
0
0
42
389
1.09
0.17
1.5
1.5
—
—
—
0
0
8
73
1.10
0.16
1.4
1.4
—
—
—
0
0
122
1179
1.05
0.15
4.8
5.2
2.05
2.38
ug/l
0.28
104
1061
28
302
0.92
0.12
2.3
2.4
9.83
10.56
g/l
0.46
23
276
37
347
1.07
0.12
1.5
1.6
—
—
—
0
0
5
60
0.83
0.08
1.0
1.1
—
—
—
0
0
6
75
0.80
0.07
1.0
1.1
—
—
—
0
0
318
3165
1.03
0.05
6.3
5.5
1.32
1.46
mmol/l
9.31
284
2902
23
222
1.04
0.02
1.3
1.5
—
—
—
0
0
15
144
1.04
0.00
1.1
1.2
—
—
—
0
0
22
217
1.01
0.00
1.3
1.2
—
—
—
0
0
323
3233
0.99
0.00
7.2
6.4
2.35
2.68
mmol/l
10.49
294
2974
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
7840.57
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.3
—
7.85
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
91
0.99
-0.00
1.4
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
27.71
—
0
7
40
400
1.00
-0.00
2.4
4.7
4.15
24.05
ug/l
1.00
32
341
0
5
0.00
-0.00
0.0
1.4
—
1.99
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
31.15
—
0
8
9
98
0.92
-0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
1.21
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.02
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
57.60
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint OTHER_DRUGADVERS_SECONDA_PARKINSONI and mortality.

Females

Parameter HR [95% CI] p-value
OTHER_DRUGADVERS_SECONDA_PARKINSONI 2.378 [2.09, 2.71] < 0.001
Birth year 0.994 [0.99, 1.0] 0.129

During the follow-up period (1.1.1998 — 31.12.2019), 653 out of 1405 females with OTHER_DRUGADVERS_SECONDA_PARKINSONI died.

Males

Parameter HR [95% CI] p-value
OTHER_DRUGADVERS_SECONDA_PARKINSONI 2.878 [2.39, 3.47] < 0.001
Birth year 0.987 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 476 out of 955 males with OTHER_DRUGADVERS_SECONDA_PARKINSONI died.

Mortality risk

Mortality risk for people of age

years, who have OTHER_DRUGADVERS_SECONDA_PARKINSONI.

N-year risk Females Males
1 0.252% 0.529%
5 1.105% 3.197%
10 3.376% 7.776%
15 6.141% 14.768%
20 10.724% 23.847%

Relationships between endpoints

↥

Index endpoint: OTHER_DRUGADVERS_SECONDA_PARKINSONI – Other drug-induced secondary parkinsonism

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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