No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
647 |
4. Check minimum number of eventsNone |
647 |
5. Include endpointsNone |
647 |
6. Filter based on genotype QC (FinnGen only) |
576 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis non specificata
Similar endpoints
↥List of similar endpoints to
Thyroiditis, unspecified
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4136 | 3328 | 780 |
| Only index persons | 3597 | 2934 | 663 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.02 |
| Only index persons | 0.09 | 0.11 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 43.92 | 43.41 | 45.87 |
| Only index persons | 42.03 | 41.65 | 43.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 576 | 481 | 95 |
| Unadjusted period prevalence (%) | 0.15 | 0.17 | 0.04 |
| Median age at first event (years) | 41.60 | 41.17 | 43.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 599
- Matched controls
- 5990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
114.7
307.7
336
66
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
184.4
307.7
198
16
E06.9
ICD-10 Finland
Thyroiditis, unspecified
+∞
307.7
434
*
104
Kela drug reimbursment
Thyroid insufficiency
447.7
142.3
137
*
24509
ICD-8 Finland
Thyroiditis, Unspecified
+∞
116.6
108
*
H03BB01
ATC
carbimazole; oral
302.9
102.2
101
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
84.4
79
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
280.8
74.2
74
*
E03
ICD-10 Finland
Other hypothyroidism
267.9
70.9
71
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
172.5
60.2
62
*
2459X
ICD-9 Finland
Thyroiditis, unspecified
+∞
59.4
56
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
553.8
52.3
51
*
T86
ICPC
Hypothyroidism/myxoedema
73.9
48.0
54
8
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
45.4
43
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
71.2
35.4
40
6
BAA60
NOMESCO Finland
Total thyroidectomy
345.2
33.2
33
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
31.5
30
*
E06.3
ICD-10 Finland
Autoimmune thyroiditis
116.2
31.0
33
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.3
30.0
64
132
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
94.1
24.9
27
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
23.2
23.3
33
15
C07AA05
ATC
propranolol; systemic
2.5
20.5
170
825
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
37.2
20.0
25
7
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
19.9
19
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
57.0
19.0
22
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
35.6
19.0
24
7
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
18.0
267
1637
H02AB06
ATC
prednisolone; systemic
2.1
17.1
312
2056
H02AB07
ATC
prednisone; oral
2.6
16.4
106
453
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
13.0
185
1090
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
12.5
12
*
E06
ICD-10 Finland
Thyroiditis
+∞
12.5
12
*
A02BC02
ATC
pantoprazole; systemic
2.0
12.2
425
3330
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.1
12.2
34
87
A04
ICPC
Weakness/tiredness general
2.2
12.0
113
568
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
11.6
134
728
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
9.5
11.6
23
25
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
11.5
11
*
BA1AE, ,
SPAT
12.2
10.9
19
16
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
10.4
10
*
M79.6
ICD-10 Finland
Pain in limb
1.7
10.1
293
2121
T85
ICPC
Hyperthyroidism/thyrotoxicosis
40.8
10.0
12
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
9.9
93
465
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
101.6
9.4
10
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
9.4
9
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
9.3
87
434
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
12.8
8.9
15
12
N02AX02
ATC
tramadol; systemic, rectal
1.7
8.9
254
1813
C07AB07
ATC
bisoprolol; oral
1.7
8.8
263
1896
A02BC05
ATC
esomeprazole; systemic
1.7
8.8
252
1797
R52.9
ICD-10 Finland
Pain, unspecified
2.3
8.5
71
337
R53
ICD-10 Finland
Malaise and fatigue
1.8
8.5
165
1053
N03AX16
ATC
[U] pregabalin
1.8
8.5
149
924
R06.0
ICD-10 Finland
Dyspnoea
1.8
8.4
165
1056
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
91.3
8.4
9
*
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
8.3
8
*
E03.82
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
8.3
8
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
8.3
8
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
8.3
101
556
M54.5
ICD-10 Finland
Low back pain
1.7
8.2
234
1660
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
8.2
130
781
UJF32
NOMESCO Finland
Coloscopy
1.8
8.1
150
945
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
7.8
113
657
R51.80
ICD-10 Finland
Headache
1.9
7.7
115
675
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
18.6
7.6
11
6
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
7.5
79
411
XF404
NOMESCO Finland
Ambulatory ECG
2.4
7.5
53
235
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
81.1
7.4
8
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
7.4
165
1092
D02
ICPC
Abdominal pain epigastric
2.4
7.4
49
211
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
7.3
7
*
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
7.3
7
*
N06AX11
ATC
mirtazapine; oral
1.6
7.3
210
1485
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.8
7.2
120
728
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.7
7.2
39
152
R06AX27
ATC
desloratadine; oral
1.7
7.2
191
1322
K30
ICD-10 Finland
Functional dyspepsia
2.0
7.0
79
421
UKC02
NOMESCO Finland
Cystoscopy
2.0
6.9
73
380
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
6.9
72
373
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
6.9
258
1934
R03AC02
ATC
salbutamol; inhalant
1.6
6.8
340
2723
G44.2
ICD-10 Finland
Tension-type headache
1.8
6.7
100
586
A10AB01
ATC
insulin (human); parenteral
3.3
6.6
25
79
A02BA02
ATC
ranitidine; systemic
1.8
6.6
112
683
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.1
6.6
27
90
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
6.5
68
353
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.5
212
1535
A02BC01
ATC
omeprazole; systemic
1.7
6.5
159
1074
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
6.5
162
1100
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
6.4
164
1119
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
6.4
200
1433
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
6.3
326
2615
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
6.3
6
*
D11
ICPC
Diarrhoea
1.9
6.2
83
469
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.8
6.1
18
48
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
6.1
130
844
H92.0
ICD-10 Finland
Otalgia
2.3
6.1
45
203
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
2.4
6.1
41
178
SPAT1262
SPAT
Handing over of treatment supplies
1.9
6.1
86
496
R06.2
ICD-10 Finland
Wheezing
2.6
6.1
33
129
B03BA03
ATC
hydroxocobalamin; parenteral
2.6
6.1
34
135
A02BC03
ATC
lansoprazole; oral
1.6
6.0
168
1168
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
172
166
14.13
163.91
4.2
1.4
4.46
4.49
pmol/l
0.11
156
147
113
71
19.38
136.24
2.5
1.2
2.23
1.44
iu/l
1.78
43
18
154
298
6.61
80.24
1.6
1.1
262.91
72.64
u/ml
4.75
74
94
546
4059
4.90
31.67
10.0
2.8
15.31
14.33
pmol/l
14.40
521
3739
368
2666
1.99
14.49
3.8
2.9
104.08
91.36
ug/l
0.78
333
2507
480
3878
2.20
13.34
5.9
4.2
12.68
11.41
mm/h
1.09
458
3628
557
4829
3.19
12.92
11.7
3.9
1.86
1.84
mu/l
0.13
529
4498
395
3024
1.90
12.15
9.9
9.0
4.14
4.04
e9/l
0.36
356
2620
307
2182
1.83
11.88
6.7
5.3
1.21
1.22
mmol/l
0.43
281
2020
479
3929
2.09
11.85
8.5
7.3
78.82
77.35
u/l
0.15
457
3738
382
2918
1.85
11.55
5.4
4.3
6.59
6.47
mmol/l
0.65
366
2734
327
2413
1.78
10.77
2.9
2.5
78.94
77.64
nmol/l
0.35
291
2213
329
2448
1.76
10.38
7.6
6.0
1.22
1.22
mmol/l
0.00
280
2130
260
1810
1.77
10.34
4.9
3.4
26.88
31.11
ng/l
0.36
165
1162
295
2144
1.74
9.98
15.8
11.7
1.23
1.18
inr
0.84
263
1745
198
1302
1.78
9.38
2.5
2.2
2.73
2.79
mg/l
0.14
170
1124
58
241
2.56
9.37
2.2
2.1
6.23
7.77
iu/ml
0.16
18
57
35
110
3.32
9.32
1.3
1.2
—
—
—
0
0
86
436
2.14
8.80
2.2
1.9
376.35
383.86
nmol/l
0.14
74
408
131
772
1.89
8.79
2.7
2.3
12.89
13.39
umol/l
0.33
117
717
198
1328
1.73
8.63
1.5
1.3
1.35
2.06
u/ml
0.41
42
356
290
2158
1.67
8.54
2.3
2.0
96.60
95.69
pmol/l
0.11
148
1106
177
1153
1.76
8.53
1.7
1.4
2.12
2.36
g/l
1.18
100
714
420
3448
1.73
8.46
6.0
4.5
3911.00
4571.85
e6/l
—
8
46
184
1216
1.74
8.41
2.2
1.7
0.83
1.10
mg/l
1.33
139
932
345
2693
1.66
8.37
5.9
5.8
9.42
10.91
umol/l
1.87
325
2570
215
1497
1.68
8.05
2.5
2.0
148.06
172.29
u/l
0.40
205
1432
121
725
1.84
7.63
2.6
2.2
2.38
2.34
g/l
0.30
105
675
191
1311
1.67
7.45
3.5
2.9
2213.82
991.26
ng/l
1.88
159
1111
239
1755
1.60
7.03
2.5
3.3
2.33
2.36
mmol/l
3.58
210
1603
220
1585
1.61
6.99
3.0
2.3
56.78
65.30
u/l
0.89
208
1471
357
2892
1.58
6.79
4.6
3.8
0.00
0.02
estimate
1.23
64
550
110
663
1.81
6.76
2.6
2.3
21.47
22.92
%
0.48
94
620
353
2869
1.56
6.49
4.5
3.8
0.00
11.16
estimate
1.33
66
575
349
2839
1.55
6.31
4.5
3.7
0.00
0.00
estimate
0.50
66
562
280
2171
1.54
6.30
4.2
4.4
35.53
36.12
g/l
0.98
263
2045
560
5160
2.31
6.25
22.4
15.3
3.93
3.94
mmol/l
0.26
554
5033
114
713
1.74
6.14
1.9
1.7
1183.43
1208.13
nmol/l
0.09
96
535
558
5143
2.24
6.07
21.3
13.4
19.75
22.54
mg/l
1.41
476
4179
558
5152
2.21
5.89
22.5
15.2
139.55
139.70
mmol/l
0.76
553
5046
175
1237
1.59
5.84
2.2
2.4
321.31
320.72
umol/l
0.02
152
1113
33
133
2.57
5.71
2.6
2.5
—
—
—
0
0
40
177
2.35
5.69
1.4
1.2
9.86
25.46
u/ml
—
5
13
153
1054
1.61
5.67
1.5
1.3
7.40
9.49
u/ml
0.23
68
420
66
358
1.95
5.60
3.1
3.5
95.13
79.27
ng/l
0.54
60
314
120
789
1.65
5.33
3.2
2.9
0.85
0.82
mmol/l
2.45
114
750
46
225
2.13
5.17
3.5
3.6
3.22
1.88
mmol/l
0.94
37
164
60
325
1.94
5.12
3.2
2.9
145.12
159.99
ng/l
0.15
55
300
230
1782
1.47
4.84
3.3
3.0
29.65
29.77
u/l
0.03
220
1692
19
62
3.13
4.83
1.2
1.2
—
—
—
0
0
19
62
3.13
4.83
1.1
1.2
—
—
—
0
0
171
1249
1.52
4.80
4.5
3.8
1.01
2.25
kg/l
0.50
125
821
212
1629
1.47
4.60
3.4
3.0
45.40
103.47
e6/l
0.63
167
1218
530
4895
1.72
4.35
17.5
13.1
83.25
83.74
ml/min/173m2
0.21
491
4489
158
1159
1.49
4.29
1.5
1.3
24.06
30.24
iu/ml
0.45
57
344
35
166
2.18
4.28
1.5
1.3
5.30
3.21
u/ml
—
6
19
35
166
2.18
4.28
1.5
1.3
8.70
6.28
u/ml
—
7
29
134
950
1.53
4.27
5.2
3.5
57.21
316.94
ng/l
2.55
89
680
18
62
2.96
4.20
1.1
1.2
—
—
—
0
0
203
1583
1.43
3.96
3.5
3.1
0.02
0.02
estimate
0.01
52
458
150
1105
1.48
3.95
2.7
2.5
10.82
6.64
e6/l
0.81
136
1000
35
172
2.10
3.93
1.7
1.4
0.01
0.10
iu/ml
—
8
32
17
59
2.94
3.93
1.2
1.2
—
—
—
0
0
17
60
2.89
3.82
1.2
1.2
—
—
—
0
0
17
60
2.89
3.82
1.2
1.2
—
—
—
0
0
39
202
2.00
3.82
1.6
1.7
—
—
—
0
0
77
492
1.65
3.80
2.5
2.2
30.22
36.40
u/l
0.88
63
405
16
55
2.96
3.76
1.2
1.2
—
—
—
0
0
148
1105
1.45
3.61
1.9
1.6
—
—
—
0
0
527
4910
1.61
3.56
5.4
4.7
5.87
5.79
mmol/l
0.60
485
4540
14
46
3.09
3.55
1.2
1.2
—
—
—
0
0
262
2168
1.37
3.51
4.4
3.6
0.08
0.05
estimate
0.14
53
471
114
813
1.50
3.50
2.1
1.9
—
—
—
0
0
180
1403
1.40
3.45
1.9
1.6
18.61
21.57
nmol/l
2.17
147
1180
165
1268
1.42
3.42
2.8
2.1
—
—
—
0
0
567
5399
1.94
3.39
14.1
10.9
25.02
24.52
u/l
0.40
554
5265
177
1380
1.40
3.37
3.3
2.9
0.33
0.45
e6/l
0.55
132
972
203
1620
1.38
3.37
3.3
3.2
6.70
7.26
mmol/l
0.86
165
1390
16
59
2.76
3.34
1.2
1.5
285.82
307.47
mu/l
0.25
11
49
192
1520
1.39
3.34
3.9
3.9
10.65
9.76
mg/mmol
0.08
122
932
514
4777
1.54
3.34
6.8
5.6
39.47
38.42
mmol/mol
1.63
474
4512
14
48
2.96
3.32
1.2
1.1
—
—
—
0
0
14
48
2.96
3.32
1.2
1.1
—
—
—
0
0
35
184
1.96
3.31
2.1
1.9
1.75
1.43
g/l
0.98
29
164
132
980
1.45
3.30
1.8
1.7
421.74
38164684.95
pmol/l
1.58
104
828
169
1314
1.40
3.26
4.6
3.7
95.34
94.34
%
0.23
163
1286
33
172
1.97
3.21
2.3
1.8
—
—
—
0
0
55
338
1.69
3.17
2.1
2.3
3.94
5.58
ug/l
1.02
46
300
398
3551
1.36
3.12
3.8
3.3
—
—
—
0
0
191
1532
1.36
3.02
4.7
3.9
0.00
0.00
estimate
0.80
60
536
398
3560
1.35
3.01
3.7
3.1
41.62
41.34
u/l
0.03
377
3378
20
88
2.32
2.96
1.7
1.7
—
—
—
0
0
55
345
1.65
2.94
1.6
1.5
—
—
—
0
0
13
46
2.87
2.93
1.2
1.2
—
—
—
0
0
14
52
2.73
2.90
1.2
1.1
—
—
—
0
0
30
157
1.96
2.90
2.2
1.7
—
—
—
0
0
86
602
1.50
2.89
6.2
5.8
104.23
104.47
mmol/l
0.16
86
602
10
28
3.61
2.79
3.4
4.3
1165.20
601.39
u/ml
—
10
28
9
23
3.96
2.78
1.2
1.0
5.57
5.82
umol/l
—
9
18
35
197
1.82
2.74
1.3
1.8
4.05
4.26
g/l
1.02
30
184
35
197
1.82
2.74
1.3
1.8
7.17
7.41
g/l
0.31
30
184
57
369
1.60
2.71
2.0
2.5
65.45
67.65
g/l
1.20
48
344
31
169
1.88
2.68
1.6
1.8
0.81
2.66
ug/l
0.56
26
155
57
372
1.59
2.63
7.1
5.8
11.30
8.61
mmol/l
1.80
57
358
36
210
1.76
2.53
2.3
2.1
9.39
11.98
nmol/l
1.05
31
192
46
288
1.65
2.51
1.6
1.7
—
—
—
0
0
85
613
1.45
2.47
1.9
1.8
—
—
—
0
0
28
152
1.88
2.47
1.3
1.2
—
—
—
0
0
34
197
1.77
2.45
1.3
1.8
3.59
3.86
g/l
0.62
29
184
42
260
1.66
2.40
9.5
6.7
25.03
24.56
mmol/l
0.42
42
248
60
407
1.53
2.35
1.4
1.3
135.14
195.22
u/ml
0.54
55
380
101
760
1.40
2.33
3.3
2.8
4.43
3.44
e6/l
0.27
49
336
62
426
1.51
2.30
7.9
7.2
119.97
119.73
g/l
0.03
62
417
32
186
1.76
2.29
1.3
1.8
3.01
2.93
g/l
0.13
27
173
6
13
4.65
2.27
1.2
1.2
—
—
—
0
0
80
580
1.44
2.27
2.5
2.7
5.45
6.62
umol/l
0.62
66
503
71
508
1.45
2.16
7.3
6.7
1.69
1.09
mmol/l
0.86
65
415
7
19
3.71
2.15
1.1
1.3
156.37
206.07
iu/ml
—
7
19
30
176
1.74
2.10
1.3
2.0
0.00
1.04
g/l
2.22
24
154
125
991
1.33
2.07
2.3
2.6
2.42
2.45
mmol/l
3.26
112
894
5
10
5.03
2.07
1.2
1.1
103.00
101.30
%
—
5
10
578
5614
1.84
2.07
32.3
20.8
263.23
258.52
e9/l
0.98
570
5514
578
5617
1.83
2.01
32.2
20.7
90.45
90.93
fl
1.96
578
5565
37
233
1.63
2.01
1.7
1.9
2.99
3.17
mg/l
0.08
26
172
71
516
1.43
2.00
6.6
6.2
—
—
—
0
0
578
5618
1.82
2.00
32.3
20.8
4.43
4.45
e12/l
0.41
570
5497
578
5620
1.81
1.96
32.5
20.9
132.14
133.46
g/l
1.72
578
5564
280
2477
1.24
1.91
3.2
2.5
—
—
estimate
—
0
0
77
573
1.39
1.91
5.0
4.4
32.94
32.62
%
0.09
54
380
505
4796
1.34
1.83
4.7
3.9
1.29
1.23
mmol/l
1.12
467
4461
18
94
1.94
1.82
1.1
1.3
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
7
23
3.07
1.80
1.4
2.5
97.19
125.13
%
—
7
23
531
5085
1.39
1.80
5.6
4.7
4.69
4.78
mmol/l
1.14
492
4789
23
132
1.77
1.76
3.1
3.6
2.00
2.48
index
0.17
14
67
8
30
2.69
1.73
1.3
1.1
11.50
9.47
mm/h
—
8
30
8
30
2.69
1.73
1.4
1.1
—
—
—
0
0
18
96
1.90
1.72
2.0
2.0
3.69
4.68
mmol/24h
1.08
18
85
529
5071
1.37
1.70
5.5
4.6
1.51
1.55
mmol/l
1.50
486
4753
33
212
1.59
1.69
1.8
1.7
8.73
10.08
u/ml
—
10
47
53
378
1.44
1.68
3.2
3.3
1.22
1.23
mmol/l
1.12
41
335
28
173
1.65
1.67
1.3
1.7
10.14
10.45
g/l
0.16
23
159
14
71
2.00
1.55
1.2
1.3
—
—
—
0
0
8
33
2.44
1.54
1.3
1.9
22.79
22.55
nmol/l
—
8
33
21
123
1.73
1.52
1.6
1.3
—
—
—
0
0
7
27
2.61
1.52
1.3
1.1
—
—
—
0
0
18
101
1.81
1.50
2.1
2.6
4.03
6.71
umol/l
0.87
13
75
37
254
1.49
1.44
8.2
7.3
15.79
15.66
%
0.12
37
244
51
373
1.40
1.43
2.5
2.4
11.15
19.98
au/ml
—
6
40
103
839
1.27
1.41
3.3
2.7
1.07
1.19
e6/l
0.20
54
416
9
41
2.21
1.37
2.0
2.1
—
—
—
0
0
6
23
2.62
1.37
1.2
1.1
—
—
—
0
0
9
42
2.16
1.34
1.3
1.1
128.78
121.60
pmol/l
—
9
42
53
396
1.37
1.33
1.6
1.5
—
—
—
0
0
39
276
1.44
1.32
2.9
2.1
1263.45
6039.07
u/l
1.67
21
111
6
24
2.51
1.30
1.7
1.2
—
—
—
0
0
6
24
2.51
1.30
1.7
1.2
—
—
—
0
0
5
18
2.79
1.28
1.4
2.2
41.96
43.56
g/l
—
5
18
15
84
1.81
1.28
1.3
1.4
—
—
—
0
0
15
84
1.81
1.28
1.3
1.4
—
—
—
0
0
16
93
1.74
1.22
1.7
1.2
5.00
2.94
u/ml
—
7
34
22
141
1.58
1.19
1.4
1.2
—
—
—
0
0
532
5152
1.29
1.18
6.3
5.3
2.73
2.79
mmol/l
0.93
490
4834
40
292
1.40
1.17
3.4
2.8
132.53
128.97
g/l
0.48
40
282
36
258
1.42
1.16
1.3
1.5
—
—
—
0
0
19
118
1.63
1.16
2.2
2.1
134.71
129.07
g/l
0.73
14
89
73
585
1.28
1.16
2.0
1.8
—
—
—
0
0
5
21
2.39
1.09
1.2
1.0
—
—
—
0
0
25
169
1.50
1.09
1.3
1.3
—
—
—
0
0
15
89
1.70
1.08
1.9
2.5
8.65
8.31
pmol/l
0.04
15
89
21
137
1.55
1.07
1.2
1.1
0.75
2.19
u/ml
—
10
69
7
33
2.13
1.06
2.3
2.2
—
—
—
0
0
10
53
1.90
1.01
1.1
1.1
—
—
—
0
0
10
176
0.56
1.01
1.7
1.6
—
—
—
0
0
0
30
0.00
0.97
0.0
1.6
—
—
—
0
0
6
27
2.23
0.93
1.7
3.8
128.67
100.11
%
—
6
27
239
2195
1.15
0.90
2.1
1.9
1.39
1.33
mmol/l
0.34
192
1888
12
71
1.70
0.89
1.8
1.4
—
—
—
0
0
24
169
1.44
0.89
1.7
1.3
—
—
—
0
0
16
103
1.57
0.88
1.8
1.8
—
—
—
0
0
15
95
1.59
0.88
1.7
1.2
1.40
4.07
u/ml
—
5
29
23
162
1.44
0.85
1.2
1.1
—
—
—
0
0
49
393
1.27
0.81
2.1
2.4
68.79
71.81
ml/min/173m2
0.17
19
158
29
216
1.36
0.80
1.4
1.6
58.00
62.18
ug/l
0.21
23
180
10
58
1.74
0.80
1.3
1.1
—
—
—
0
0
16
106
1.52
0.79
5.0
3.4
26.25
29.16
mg/l
—
8
67
8
48
1.68
0.79
1.3
1.4
—
—
—
0
0
10
59
1.71
0.76
3.7
3.7
—
—
—
0
0
7
38
1.85
0.73
1.3
1.3
—
—
—
0
0
20
142
1.42
0.73
1.4
3.1
1.26
4.61
ratio
0.64
14
75
7
39
1.80
0.72
1.3
1.4
—
—
—
0
0
22
161
1.38
0.69
1.2
1.1
—
—
—
0
0
18
127
1.43
0.68
1.4
1.4
3.62
3.66
mmol/l
0.04
18
118
75
646
1.18
0.66
5.9
5.2
5.85
2.54
ug/l
0.42
70
578
60
507
1.20
0.65
1.8
1.8
3.66
3.45
mmol/l
0.67
45
365
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
5
30
1.67
0.61
1.0
1.1
—
—
—
0
0
19
139
1.38
0.61
1.5
1.5
565.16
491.48
mg/l
0.31
19
131
13
88
1.49
0.61
2.0
1.6
—
—
—
0
0
8
51
1.58
0.60
1.3
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
70
607
1.17
0.58
1.5
1.8
1.42
1.41
%
0.05
62
535
74
648
1.16
0.55
2.0
2.0
3.40
3.30
ratio
0.29
56
507
26
204
1.29
0.55
1.4
1.5
—
—
—
0
0
60
517
1.18
0.54
2.4
4.0
2.56
17.38
ug/l
1.08
44
412
46
387
1.20
0.54
3.1
3.0
0.67
0.75
ug/l
0.49
33
244
26
205
1.28
0.53
1.4
1.5
1.03
1.17
ratio
0.25
16
133
26
205
1.28
0.53
1.4
1.5
1.13
1.21
ratio
0.23
16
133
26
205
1.28
0.53
1.4
1.5
0.90
0.95
ratio
0.31
16
133
16
117
1.38
0.52
1.5
1.4
—
—
—
0
0
44
370
1.20
0.52
1.5
1.6
934.33
995.74
mu/l
0.23
36
304
38
316
1.22
0.51
1.0
1.0
—
—
—
0
0
28
226
1.25
0.49
1.5
1.3
168.27
257.35
miu/ml
0.71
15
120
31
254
1.23
0.48
1.4
1.5
—
—
—
0
0
55
478
1.17
0.47
2.4
1.9
—
—
—
0
0
47
405
1.17
0.44
1.3
1.4
31.16
28.94
iu/l
0.14
37
350
17
131
1.31
0.42
1.3
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
2.0
—
—
—
0
0
5
34
1.47
0.40
1.6
1.0
—
—
—
0
0
8
60
1.34
0.40
2.0
2.2
1.19
1.19
mmol/l
—
8
60
8
61
1.32
0.39
2.0
2.2
105.00
106.26
mmol/l
—
8
61
5
35
1.43
0.39
1.6
1.3
—
—
—
0
0
15
115
1.31
0.39
2.1
1.6
10291.10
11600.91
e6/l
—
10
76
12
158
0.75
0.37
2.3
1.7
—
—
—
0
0
5
37
1.35
0.37
1.2
1.6
0.18
1.16
promille
—
5
28
55
490
1.13
0.36
3.5
3.0
—
—
—
0
0
58
519
1.13
0.35
4.4
4.3
19.17
22.11
%
0.98
29
241
11
82
1.35
0.34
1.4
1.1
—
—
—
0
0
13
101
1.29
0.32
2.8
1.6
9.89
2.69
ug/l
0.38
13
91
13
102
1.28
0.30
1.5
1.6
—
—
—
0
0
7
57
1.23
0.29
1.3
1.1
—
—
—
0
0
24
205
1.18
0.28
6.8
4.3
1.73
1.51
%
0.45
24
192
28
243
1.16
0.27
2.6
3.3
1.01
1.02
ratio
0.53
23
228
8
66
1.21
0.27
1.1
1.6
—
—
—
0
0
10
77
1.30
0.26
1.6
1.3
—
—
—
0
0
24
207
1.17
0.25
3.8
3.1
25.91
25.25
mmol/l
0.46
24
201
9
75
1.20
0.25
1.4
1.4
—
—
—
0
0
19
223
0.85
0.24
1.4
1.1
1.59
1.58
g/l
0.10
19
223
12
96
1.26
0.24
1.4
1.4
—
—
—
0
0
12
96
1.26
0.24
1.3
1.4
—
—
—
0
0
16
134
1.20
0.23
1.4
1.6
—
—
—
0
0
15
125
1.21
0.22
2.0
1.5
—
—
—
0
0
5
40
1.25
0.22
1.0
2.0
—
—
—
0
0
24
210
1.15
0.22
3.1
1.7
—
—
—
0
0
5
42
1.19
0.21
1.2
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
1.20
—
0
10
14
117
1.20
0.20
1.1
1.1
2.41
0.70
u/ml
—
7
55
0
14
0.00
0.20
0.0
1.4
—
8.20
—
0
8
20
227
0.88
0.18
1.4
1.2
0.97
0.90
g/l
0.39
20
227
7
59
1.19
0.18
3.9
2.3
10.71
10.43
mmol/l
—
7
59
7
62
1.13
0.17
1.3
1.1
—
—
—
0
0
7
62
1.13
0.17
1.1
1.5
—
—
—
0
0
15
129
1.17
0.17
1.1
1.4
236.75
308.12
ug/g
—
8
75
5
67
0.74
0.17
1.0
1.1
—
—
—
0
0
14
123
1.14
0.12
1.4
1.8
366.43
274.96
e6/l
0.09
14
91
75
719
1.05
0.12
2.1
2.2
—
—
—
0
0
127
1233
1.04
0.12
1.6
1.5
—
—
—
0
0
31
288
1.08
0.12
1.5
1.5
—
—
—
0
0
5
44
1.14
0.10
1.0
1.9
—
—
—
0
0
7
65
1.08
0.08
2.1
1.3
0.73
29.38
nmol/l
—
7
59
6
73
0.82
0.07
1.3
1.3
7.18
7.30
mmol/l
—
6
59
8
76
1.05
0.07
1.1
1.1
—
—
—
0
0
32
304
1.06
0.07
1.6
1.4
—
—
—
0
0
20
212
0.94
0.05
1.2
1.6
0.14
0.36
mg/l
—
8
88
68
664
1.03
0.05
1.8
2.0
—
—
—
0
0
40
387
1.04
0.04
2.1
1.8
—
—
—
0
0
15
157
0.95
0.01
2.2
3.3
1.35
1.40
mg/l
0.24
15
143
13
134
0.97
0.00
1.8
1.5
62.89
54.10
ug/l
0.20
13
134
25
254
0.98
0.00
1.2
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
1.3
1.3
16.28
13.64
u/l
—
7
64
5
59
0.85
-0.00
1.4
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
14.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
-0.00
2.9
1.9
13.10
13.26
%
—
7
77
8
82
0.98
-0.00
1.1
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITNAS | 1.07 [0.88, 1.3] | 0.502 |
| Birth year | 0.992 [0.98, 1.0] | 0.081 |
During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 1872 females with E4_THYROIDITNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITNAS | 1.031 [0.79, 1.35] | 0.827 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 435 males with E4_THYROIDITNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYROIDITNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.199% |
| 5 | 0.55% | 1.133% |
| 10 | 1.31% | 2.965% |
| 15 | 2.674% | 5.73% |
| 20 | 4.741% | 9.773% |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITNAS – Thyroiditis, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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