cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2215 |
4. Check minimum number of eventsNone |
2215 |
5. Include endpointsNone |
2215 |
6. Filter based on genotype QC (FinnGen only) |
1971 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H65-H75
- Name in latin
- Cholesteatoma auris mediae
Similar endpoints
↥List of similar endpoints to
Cholesteatoma of middle ear
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17391 | 7390 | 9876 |
| Only index persons | 15196 | 6641 | 8555 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.21 | 0.28 |
| Only index persons | 0.29 | 0.24 | 0.33 |
| Median age at first event (years) | |||
| Whole population | 46.07 | 49.35 | 43.53 |
| Only index persons | 44.52 | 48.24 | 41.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1971 | 874 | 1097 |
| Unadjusted period prevalence (%) | 0.42 | 0.31 | 0.50 |
| Median age at first event (years) | 49.33 | 47.84 | 50.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2055
- Matched controls
- 20550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.1
319.0
755
1795
H66.0
ICD-10 Finland
Acute suppurative otitis media
10.8
310.7
366
403
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
113.8
307.7
177
17
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
325.1
307.7
328
12
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
35.1
307.7
349
119
H65.3
ICD-10 Finland
Chronic mucoid otitis media
295.8
307.7
281
11
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
307.7
346
*
DC1AD
NOMESCO Finland
Temporalbone CT
142.8
307.7
355
30
DFF00
NOMESCO Finland
Pure tone audiometry
7.5
307.7
693
1298
UDC00
NOMESCO Finland
Ear microscopy
14.2
307.7
684
696
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
189.1
307.7
189
11
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
307.7
466
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
307.7
1669
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
30.3
306.3
205
75
H66.9
ICD-10 Finland
Otitis media, unspecified
9.6
245.9
311
373
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
235.0
221
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
106.1
233.0
120
12
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
24.2
217.4
157
70
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
39.1
214.5
132
36
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
205.8
194
*
DCD10
NOMESCO Finland
Tympanoplasty
547.6
203.5
199
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
198.2
187
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
190.6
180
*
DCD00
NOMESCO Finland
Myringoplasty
1994.8
182.0
174
*
DEB30
NOMESCO Finland
Radical mastoidectomy
954.3
181.1
175
*
H60.4
ICD-10 Finland
Cholesteatoma of external ear
76.6
176.8
95
13
TDA90
NOMESCO Finland
Removal wax from ear
16.1
171.5
149
99
H60.9
ICD-10 Finland
Otitis externa, unspecified
5.9
168.8
342
677
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
34.6
160.4
102
31
H74.1
ICD-10 Finland
Adhesive middle ear disease
1516.9
145.6
140
*
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
1476.7
142.4
137
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
142.4
135
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
10.4
141.8
162
167
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
21.2
138.7
105
52
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
192.0
138.5
143
8
H65.2
ICD-10 Finland
Chronic serous otitis media
244.5
134.7
137
6
Z97.4
ICD-10 Finland
Presence of external hearing-aid
5.3
128.4
285
607
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
4.6
125.1
341
860
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.2
124.8
677
2717
H60.3
ICD-10 Finland
Other infective otitis externa
9.4
124.4
153
174
S02CA02
ATC
flumetasone and antiinfectives; otic
5.4
120.7
261
542
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
118.9
113
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
110.4
105
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
376.6
108.4
108
*
DFF15
NOMESCO Finland
Speech audiometry
4.7
100.6
252
590
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
41.2
99.0
60
15
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
4.4
96.8
265
665
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
96.6
92
*
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
94.5
90
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.8
94.1
331
996
H65.0
ICD-10 Finland
Acute serous otitis media
17.0
92.1
77
47
H60.8
ICD-10 Finland
Other otitis externa
7.1
90.7
142
214
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
5.0
87.5
202
441
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
446.0
86.8
86
*
H61.2
ICD-10 Finland
Impacted cerumen
3.9
83.0
268
757
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
6.6
82.9
139
225
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
78.6
75
*
R5120
NOMESCO Finland
Preparation of an aid
5.2
75.8
163
334
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.5
75.7
691
3490
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
14.2
75.2
69
50
DAX08
NOMESCO Finland
Fitting of hearing aid
3.7
73.0
253
748
4151
FHL
Reoperation for chronic otitis media
+∞
71.3
68
*
H66.1
ICD-10 Finland
Chronic tubotympanic suppurative otitis media
364.5
71.1
71
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
5.3
66.5
140
281
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
30.0
66.3
44
15
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
66.0
63
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
63.9
61
*
4143
FHL
Atticotomy or atticoanthromy through the ear canal
+∞
62.8
60
*
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
14.6
59.7
54
38
H66
ICD-10 Finland
Suppurative and unspecified otitis media
7.1
59.2
90
131
4146
FHL
Radical cutting (bridge broken)
+∞
58.6
56
*
4145
FHL
Tympanomastoidectomy, includes possible tympanoplasty
552.3
54.8
54
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
53.8
1122
7615
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
278.2
53.4
54
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
53.4
51
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
53.2
371
1621
DEB35
NOMESCO Finland
Radical mastoidectomy with tympanoplasty
+∞
50.2
48
*
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
+∞
50.2
48
*
4122
FHL
Tympanostomy (tympanic tube)
130.7
48.0
51
*
H92.0
ICD-10 Finland
Otalgia
3.5
47.5
172
520
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
240.4
46.2
47
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
160.2
45.0
47
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
4.0
44.1
130
341
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
6.9
43.4
68
102
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
42.9
41
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
7.1
42.5
64
92
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
415.7
41.3
41
*
DCB00
NOMESCO Finland
Excision of lesion of middle ear
415.7
41.3
41
*
H61.8
ICD-10 Finland
Other specified disorders of external ear
7.8
40.9
57
75
S02AA03
ATC
boric acid; otic
8.7
39.2
50
59
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
+∞
38.7
37
*
ZXC10
NOMESCO Finland
Use of laser
4.8
37.3
86
186
H66.2
ICD-10 Finland
Chronic atticoantral suppurative otitis media
+∞
36.6
35
*
H04
ICPC
Ear discharge
3.7
35.7
117
330
DCA30
NOMESCO Finland
Exploration of middle ear
353.1
35.0
35
*
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
+∞
34.5
33
*
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
39.0
33.5
42
11
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
33.1
570
3484
H60
ICD-10 Finland
Otitis externa
3.2
32.9
135
440
EMB30
NOMESCO Finland
Adenotomy
8.7
31.4
40
47
R5140
NOMESCO Finland
Monitoring the use of the aid
2.2
31.0
282
1365
4451
FHL
Guitar cutting
7.1
31.0
47
68
H01
ICPC
Ear pain/earache
2.3
30.9
252
1166
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
30.5
336
1754
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
+∞
30.3
29
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
3.3
30.1
119
379
DE2DG
NOMESCO Finland
Acoustic channel very extensive MRI examination with high intensity magnet
83.9
29.8
33
*
R4135
NOMESCO Finland
Rehabilitation for hearing problems
4.3
29.6
78
188
1450
FHL
Otomicroscopy
30.5
29.5
39
13
J01DA01
ATC
[U] cefalexin
1.7
29.4
1241
9694
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
+∞
29.2
28
*
38299
ICD-8 Finland
Unspecified otitis media with mastoiditis
+∞
29.2
28
*
H90.2
ICD-10 Finland
Conductive hearing loss, unspecified
10.1
29.2
33
33
J01MA02
ATC
ciprofloxacin; systemic
1.7
27.5
851
6089
J01DC02
ATC
cefuroxime; systemic
3.0
27.4
123
422
4144
FHL
Mastoidectomy or aticomastoidectomy
+∞
27.1
26
*
UDC10
NOMESCO Finland
Tympanoscopy
98.1
26.7
29
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
26.1
25
*
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
6.9
25.9
40
59
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
+∞
25.0
24
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
253.1
24.7
25
*
H61.3
ICD-10 Finland
Acquired stenosis of external ear canal
22.2
24.3
35
16
H70.0
ICD-10 Finland
Acute mastoiditis
+∞
23.0
22
*
4148
FHL
Radical cutting and cavity filling
+∞
23.0
22
*
DEB00
NOMESCO Finland
Cortical mastoidectomy
121.4
22.6
24
*
J01CA04
ATC
amoxicillin; systemic
1.7
22.6
1596
13747
DED00
NOMESCO Finland
Obliteration of cavity after partial excision of mastoid
+∞
21.9
21
*
ZXA05
NOMESCO Finland
Left side
1.7
21.4
532
3548
J01DA06
ATC
[U] cefuroxime
1.9
21.3
291
1627
H29
ICPC
Ear symptom/complaint other
1.9
21.0
274
1508
DDD20
NOMESCO Finland
Interposition between eardrum and footplate of stapes
+∞
20.9
20
*
RK320, ,
NOMESCO Finland
6.8
20.4
32
48
ZXA00
NOMESCO Finland
Right side
1.6
20.1
564
3869
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
5.8
19.3
35
61
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
19.2
168
796
H71
ICPC
Acute otitis media/myringitis
5.7
19.0
35
62
DDD10
NOMESCO Finland
Interposition between malleus and stapes
+∞
18.8
18
*
H73.8
ICD-10 Finland
Other specified disorders of tympanic membrane
101.0
18.6
20
*
DEE00
NOMESCO Finland
Osseous fixation of hearing aid
101.0
18.6
20
*
H69.0
ICD-10 Finland
Patulous Eustachian tube
18.2
17.8
27
15
J01DB01
ATC
cefalexin; oral
1.6
17.7
1611
14193
4111
FHL
Ear canal extension
+∞
17.7
17
*
DFX03
NOMESCO Finland
Review, maintenance and user education for hearing aid
6.2
17.7
30
49
RK110, ,
NOMESCO Finland
6.4
17.6
29
46
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
181.5
17.5
18
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.3
17.5
142
652
R01AD08
ATC
fluticasone; nasal
1.6
17.2
506
3490
H72
ICD-10 Finland
Perforation of tympanic membrane
31.7
17.0
22
7
Z97.8
ICD-10 Finland
Presence of other specified devices
7.6
17.0
24
32
H91.9
ICD-10 Finland
Hearing loss, unspecified
2.3
16.8
128
572
H74.4
ICD-10 Finland
Polyp of middle ear
+∞
16.7
16
*
RK520, ,
NOMESCO Finland
13.7
16.0
27
20
ZZG00
NOMESCO Finland
Graft of cartilage
22.2
15.5
22
10
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
2.0
15.4
168
867
H80.9
ICD-10 Finland
Otosclerosis, unspecified
5.5
15.3
29
53
J01DA08
ATC
[U] cefaclor
2.0
15.2
183
976
J35.2
ICD-10 Finland
Hypertrophy of adenoids
5.3
15.1
30
57
H92.1
ICD-10 Finland
Otorrhoea
23.6
15.1
21
9
H60.1
ICD-10 Finland
Cellulitis of external ear
5.1
15.1
31
61
38400
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) acuta
+∞
14.6
14
*
R01AD09
ATC
mometasone; nasal
1.5
14.2
782
6107
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
13.9
716
5516
H83.1
ICD-10 Finland
Labyrinthine fistula
53.7
13.8
16
*
DCW00
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
13.6
13
*
3824A
ICD-9 Finland
Suppurative and unspecified otitis media, Unspecified suppurative otitis media
+∞
13.6
13
*
R42
ICD-10 Finland
Dizziness and giddiness
1.5
13.4
467
3322
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
15.5
12.6
20
13
H02AB06
ATC
prednisolone; systemic
1.4
12.6
911
7426
DC1BD
NOMESCO Finland
Temporal bone extensive CT
70.3
12.6
14
*
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
130.8
12.4
13
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
12.4
677
5245
R01BA52
ATC
pseudoephedrine, combinations; oral
1.5
12.2
498
3651
DCA40
NOMESCO Finland
Fat patching or other similar technique without opening of tympanic membrane
+∞
11.5
11
*
H74.0
ICD-10 Finland
Tympanosclerosis
+∞
11.5
11
*
RK120, ,
NOMESCO Finland
12.8
11.1
19
15
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.3
11.0
41
127
H92.2
ICD-10 Finland
Otorrhagia
9.6
10.7
21
22
H81.3
ICD-10 Finland
Other peripheral vertigo
2.6
10.7
62
245
RK530, ,
NOMESCO Finland
60.3
10.6
12
*
3810A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Acute nonsuppurative otitis media
+∞
10.4
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
10.3
347
2437
ZXD20
NOMESCO Finland
Day surgery
1.6
10.3
228
1455
ZXA10
NOMESCO Finland
Bilateral
1.5
10.3
354
2498
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
13.2
10.2
17
13
J01DA09
ATC
[U] cefadroxil
1.4
10.1
457
3402
38408
ICD-8 Finland
Other inflammatory diseases of ear, Alii definiti
40.3
10.0
12
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
9.9
1297
11447
N07CA01
ATC
betahistine; oral
1.8
9.7
150
868
H60.0
ICD-10 Finland
Abscess of external ear
7.8
9.6
21
27
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.4
9.5
65
278
DFF10
NOMESCO Finland
Measurement of acoustic impedance (tympanometry and reflex testing)
15.1
9.5
15
10
3890A
ICD-9 Finland
Deafness, Conductive deafness
100.5
9.4
10
*
4741B
ICD-9 Finland
Chronic disease of tonsils and adenoids, Hypertrophy of tonsils and adenoids[HYPERTROPHIA TONSILLAE PHARYNGICAE]
7.6
9.4
21
28
5251
FHL
Hypotension
+∞
9.4
9
*
DCB10
NOMESCO Finland
Freeing of adhesions of middle ear
+∞
9.4
9
*
RK420, ,
NOMESCO Finland
24.1
8.9
12
5
D23.2
ICD-10 Finland
Benign neoplasm: Skin of ear and external auricular canal
3.5
8.8
29
83
J01FA10
ATC
azithromycin; systemic
1.3
8.7
940
7996
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
8.7
664
5375
DEW99
NOMESCO Finland
Other operation on mastoid and temporal bone
90.4
8.4
9
*
H74.8
ICD-10 Finland
Other specified disorders of middle ear and mastoid
90.4
8.4
9
*
H91
ICD-10 Finland
Other hearing loss
3.5
8.4
28
81
3851A
ICD-9 Finland
Other disorders of middle ear and mastoid, Adhesive middle ear disease
+∞
8.3
8
*
H73.0
ICD-10 Finland
Acute myringitis
9.5
8.3
16
17
ZYC03
NOMESCO Finland
Remote contact, text-based
6.5
8.2
20
31
DBB02
NOMESCO Finland
Excision of a neoplasm from external auditory canal
33.5
8.1
10
*
H90
ICD-10 Finland
Conductive and sensorineural hearing loss
7.8
7.9
17
22
38798
ICD-8 Finland
Other disease of ear and mastoid process, Alii definiti
8.5
7.8
16
19
H95.9
ICD-10 Finland
Postprocedural disorder of ear and mastoid process, unspecified
45.1
7.7
9
*
H74.9
ICD-10 Finland
Disorder of middle ear and mastoid, unspecified
45.1
7.7
9
*
G51.0
ICD-10 Finland
Bell palsy
2.4
7.7
51
216
H70
ICPC
Otitis externa
2.6
7.6
42
163
H02
ICPC
Hearing complaint
1.4
7.5
292
2107
J01FA09
ATC
clarithromycin; systemic
1.4
7.4
492
3883
J01AA02
ATC
doxycycline; systemic
1.3
7.4
1433
13077
1451
FHL
Otomicroscopy and paper place
+∞
7.3
7
*
DC1AA
NOMESCO Finland
Temporalbone X-ray examination
+∞
7.3
7
*
H70.9
ICD-10 Finland
Mastoiditis, unspecified
+∞
7.3
7
*
DDA10
NOMESCO Finland
Exploration of ossicular chain
+∞
7.3
7
*
J01FA01
ATC
erythromycin; systemic
1.5
7.3
199
1335
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
7.2
521
4160
DDA00
NOMESCO Finland
Stapedotomy
4.3
7.2
18
42
50499
ICD-8 Finland
Deflected nasal septum
2.6
7.1
39
151
DE2BG
NOMESCO Finland
Acoustic channel MRI examination with high intensity magnet
3.4
7.1
25
75
A02BC01
ATC
omeprazole; systemic
1.3
7.1
495
3933
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
7.0
505
4033
J01FF01
ATC
clindamycin; systemic
1.3
7.0
468
3696
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.6
6.8
144
908
UKC02
NOMESCO Finland
Cystoscopy
1.4
6.8
328
2455
4161
FHL
Exploratory tympanotomy
40.2
6.8
8
*
ZZC00
NOMESCO Finland
Graft of fascia
16.7
6.7
10
6
S02CA03
ATC
hydrocortisone and antiinfectives; otic
16.7
6.7
10
6
DC1AI
NOMESCO Finland
Cone beam CT of ear
22.6
6.7
9
*
N02BE01
ATC
paracetamol; systemic, rectal
1.4
6.7
1721
16206
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.6
6.7
163
1066
WX002
NOMESCO Finland
Sedation and analgesia
1.4
6.6
346
2626
T16
ICD-10 Finland
Foreign body in ear
3.5
6.6
22
64
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
70.1
6.4
7
*
DCA00
NOMESCO Finland
Biopsy of tympanic membrane or middle ear
70.1
6.4
7
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
70.1
6.4
7
*
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
3.3
6.4
23
70
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.4
353
2700
H93.8
ICD-10 Finland
Other specified disorders of ear
14.3
6.4
10
7
R01AD12
ATC
fluticasone furoate; nasal
1.3
6.4
459
3655
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.3
6.4
531
4317
DFE00
NOMESCO Finland
Insertion of cochlear implant
8.2
6.3
13
16
WX402
NOMESCO Finland
General anaesthesia
1.4
6.3
366
2823
DDD30
NOMESCO Finland
Fixation of tympanic membrane to stapes
+∞
6.3
6
*
TDC10
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
6.3
6
*
4119
FHL
Other measure in this category
+∞
6.3
6
*
DGB00
NOMESCO Finland
Obliteration of eustachian tube
+∞
6.3
6
*
DBW99
NOMESCO Finland
Other operation on external auditory canal
26.8
6.2
8
*
P01AB01
ATC
metronidazole; oral, rectal
1.3
6.2
655
5490
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1387
12893
1.23
4.64
4.5
4.4
12.88
13.22
mm/h
0.38
1303
12012
1739
16681
1.28
3.86
18.9
18.0
27.01
26.26
mg/l
0.34
1506
14027
1183
10953
1.19
3.63
5.2
5.4
6.73
6.81
mmol/l
0.64
1124
10445
925
8418
1.18
3.38
2.3
2.2
93.42
94.73
pmol/l
0.35
503
4530
1371
12905
1.19
3.31
4.5
4.3
14.95
14.93
pmol/l
0.08
1242
11717
1779
17198
1.26
3.11
23.2
21.9
4.00
3.99
mmol/l
0.65
1740
16845
16
62
2.59
3.04
1.6
1.2
—
—
—
0
0
1775
17179
1.24
2.91
23.1
21.8
139.67
139.61
mmol/l
0.45
1736
16854
54
340
1.60
2.75
1.5
1.2
106.67
397.27
titre
—
6
22
1430
13612
1.17
2.63
7.8
8.5
78.71
80.79
u/l
0.79
1350
12928
23
114
2.03
2.56
1.8
1.8
98.36
109.79
ng/l
0.30
23
114
729
6626
1.16
2.51
3.5
3.5
7.36
7.48
mmol/l
0.30
605
5594
710
6461
1.15
2.38
4.1
4.2
7.47
9.37
mg/mmol
0.72
429
4116
1814
17669
1.23
2.34
25.4
23.8
83.37
81.58
umol/l
0.89
1791
17459
1795
17468
1.22
2.32
12.9
12.7
25.75
25.93
u/l
0.14
1740
16954
1673
16178
1.18
2.32
5.3
5.2
1.41
1.43
mmol/l
1.54
1524
14889
1712
16589
1.19
2.31
6.3
6.0
2.58
2.60
mmol/l
0.23
1572
15320
1248
11820
1.14
2.27
5.4
5.0
1169.64
1573.79
e6/l
0.13
25
182
1606
15493
1.17
2.23
5.6
5.3
2.02
1.97
mu/l
0.82
1466
14222
1683
16298
1.18
2.22
5.4
5.3
4.47
4.49
mmol/l
0.39
1548
15106
1011
9454
1.14
2.22
4.2
4.1
14.21
3.91
estimate
0.50
204
2092
910
8461
1.14
2.17
4.9
5.2
35.12
35.12
g/l
0.00
844
7922
1667
16141
1.17
2.15
5.6
5.4
6.01
6.03
mmol/l
0.20
1525
14697
543
4879
1.15
2.14
3.1
3.1
0.00
0.05
1.24
14
129
518
4649
1.15
2.07
2.2
2.5
—
—
—
0
0
208
1727
1.23
2.05
2.4
2.4
5.94
7.72
ug/l
1.37
178
1534
259
2198
1.20
2.05
5.0
5.1
31.80
32.82
%
0.65
162
1422
1840
17991
1.22
2.01
29.0
27.2
245.62
244.65
e9/l
0.25
1801
17627
575
5208
1.14
2.01
2.4
2.3
2.62
2.85
mg/l
1.92
491
4466
1841
18002
1.22
2.01
29.1
27.3
134.55
134.25
g/l
0.37
1818
17799
1840
17995
1.22
1.98
28.8
27.0
91.34
91.40
fl
0.22
1817
17788
1840
17998
1.21
1.96
29.5
27.7
40.26
40.32
%
0.09
1816
17782
1840
17998
1.21
1.96
28.9
27.1
4.47
4.45
e12/l
0.62
1794
17581
1840
18000
1.21
1.95
28.9
27.2
7.03
6.87
e9/l
1.58
1794
17579
1411
13536
1.14
1.94
24.6
23.5
332.19
332.09
g/l
0.17
1403
13458
42
274
1.54
1.93
4.8
6.4
12.74
12.24
mg/l
0.18
37
257
197
1640
1.22
1.90
2.6
2.5
0.37
0.47
e6/l
0.46
188
1573
677
6222
1.13
1.88
3.6
3.3
1790.75
1571.73
ng/l
0.30
586
5416
103
796
1.31
1.86
1.9
1.4
32.72
11.82
iu/ml
—
5
17
1033
9751
1.12
1.80
5.9
6.7
11.28
12.08
umol/l
1.49
988
9318
73
541
1.36
1.75
1.4
1.6
25.36
13.50
iu/ml
0.17
19
100
1601
15521
1.14
1.75
4.5
4.4
1.31
1.28
mmol/l
0.60
1459
14130
1647
15998
1.15
1.75
18.8
17.8
77.94
77.49
ml/min/173m2
0.36
1545
14911
1630
15822
1.15
1.75
7.1
6.8
39.96
39.88
mmol/mol
0.14
1523
14713
990
9336
1.12
1.74
4.2
4.1
0.00
0.00
estimate
0.50
200
2046
908
8524
1.12
1.72
2.7
2.9
—
—
estimate
—
0
0
99
770
1.30
1.72
2.0
1.9
—
—
—
0
0
164
1357
1.23
1.70
3.9
3.9
5.20
5.16
kpa
0.20
154
1301
1007
9512
1.12
1.70
4.3
4.1
0.00
0.17
estimate
0.55
188
1945
21
118
1.79
1.70
1.4
1.3
—
—
—
0
0
21
118
1.79
1.70
1.4
1.3
—
—
—
0
0
958
9038
1.11
1.64
18.6
17.7
1.31
1.31
inr
0.03
796
7582
35
230
1.53
1.60
1.4
1.4
—
—
—
0
0
99
782
1.28
1.56
1.9
1.9
40.74
38.82
u/l
0.36
83
684
35
232
1.52
1.54
1.4
1.4
—
—
—
0
0
481
4377
1.13
1.54
3.0
2.8
4.73
5.12
e6/l
0.32
439
4007
387
3475
1.14
1.53
1.8
1.8
1060.71
1163.15
nmol/l
1.41
286
2618
421
3807
1.13
1.49
4.6
4.2
194.93
691.55
ng/l
1.36
362
3145
9
37
2.44
1.48
1.2
1.2
1.16
1.16
mmol/l
—
9
37
15
266
0.56
1.44
1.6
1.5
—
—
—
0
0
195
1671
1.18
1.44
4.2
3.1
233.45
221.60
ng/l
0.09
185
1537
639
5934
1.11
1.43
2.3
2.2
255.21
235.44
u/l
0.14
608
5631
6
22
2.73
1.43
1.0
1.1
—
—
—
0
0
117
955
1.24
1.42
3.1
3.3
25.36
25.19
mmol/l
0.17
112
916
57
423
1.36
1.41
1.4
1.3
—
—
—
0
0
18
103
1.75
1.41
1.3
2.2
723.38
546.65
e6/l
0.73
13
88
34
231
1.48
1.37
1.4
1.4
—
—
—
0
0
616
5723
1.11
1.36
1.8
1.7
19.21
20.00
nmol/l
0.65
530
4831
76
592
1.29
1.36
1.7
1.6
16.21
18.19
u/ml
0.17
24
119
5
17
2.95
1.36
2.0
2.8
0.00
0.53
u/field
—
5
17
28
183
1.54
1.34
3.9
3.7
11.33
11.46
index
0.04
18
110
89
709
1.27
1.34
2.0
1.8
—
—
—
0
0
908
8606
1.10
1.34
6.9
6.8
1.21
1.21
mmol/l
0.22
841
7945
1004
9562
1.10
1.33
7.6
7.6
1.21
1.21
mmol/l
0.24
880
8230
631
5878
1.11
1.32
2.8
2.7
55.02
74.24
u/l
0.79
598
5444
530
4894
1.11
1.31
2.7
2.9
351.71
354.52
umol/l
0.24
469
4285
773
7279
1.10
1.30
4.2
4.2
120.45
72.46
ng/l
0.29
590
5497
58
756
0.76
1.27
2.7
3.3
29.54
5482.60
u/ml
0.88
48
651
20
123
1.63
1.24
1.5
1.8
—
—
—
0
0
24
155
1.55
1.23
1.4
1.9
5.56
7.20
umol/l
0.48
16
111
162
1388
1.18
1.23
1.5
1.5
—
—
—
0
0
332
2998
1.13
1.22
1.3
1.3
41.95
33.53
iu/ml
0.28
93
922
8
38
2.11
1.18
1.8
1.2
—
—
—
0
0
19
117
1.63
1.18
1.8
1.5
93.32
89.53
umol/l
0.11
19
117
16
261
0.61
1.17
1.7
1.5
—
—
—
0
0
451
4157
1.11
1.16
4.4
4.3
1.02
1.02
kg/l
0.39
304
2793
65
511
1.28
1.13
4.4
3.5
3.85
2.12
index
0.52
34
268
61
477
1.29
1.11
1.5
1.6
6828.26
14113.58
e6/l
2.34
39
332
505
4696
1.10
1.09
3.7
4.3
85.63
86.12
%
0.16
487
4602
745
7051
1.09
1.09
4.2
4.1
0.01
0.05
estimate
1.25
159
1705
9
163
0.55
1.08
1.4
1.5
—
—
—
0
0
90
740
1.23
1.08
3.9
4.0
24.79
24.83
mmol/l
0.05
81
687
136
1168
1.18
1.03
3.8
3.7
1.45
1.92
mmol/l
0.86
101
870
5
22
2.28
1.03
1.0
1.1
—
—
—
0
0
839
8002
1.08
1.00
2.4
2.4
79.15
77.85
nmol/l
0.64
741
7137
135
1559
0.86
0.98
4.0
3.8
1.23
1.22
mmol/l
0.31
114
1337
55
692
0.79
0.97
1.3
1.6
0.16
0.33
mg/l
5.17
26
325
379
3498
1.10
0.96
2.1
1.9
—
—
—
0
0
1062
10235
1.08
0.96
9.4
9.5
4.42
4.26
e9/l
0.84
913
8860
236
2124
1.13
0.95
7.5
7.5
—
—
—
0
0
9
51
1.77
0.94
2.1
1.3
7.48
9.11
ug/l
—
9
51
14
85
1.65
0.94
1.4
1.4
—
—
—
0
0
14
85
1.65
0.94
1.4
1.4
—
—
—
0
0
993
9552
1.08
0.93
2.7
2.8
—
—
—
0
0
31
226
1.38
0.92
1.4
1.4
—
—
—
0
0
19
126
1.51
0.91
1.7
1.6
0.77
1.10
promille
0.54
14
103
19
126
1.51
0.91
1.9
1.1
103.26
104.45
pmol/l
0.04
19
126
1149
11121
1.08
0.90
3.2
3.4
47.97
52.76
u/l
0.90
1070
10392
341
3145
1.10
0.88
3.1
2.6
2.32
2.27
g/l
0.79
317
2900
60
485
1.24
0.88
1.7
2.2
9.69
12.10
mg/l
1.61
53
448
164
1451
1.14
0.87
1.8
1.6
—
—
—
0
0
28
203
1.38
0.87
3.0
3.2
6.38
5.84
nmol/l
0.07
28
197
47
593
0.79
0.87
4.5
3.3
1.83
1.63
mg/l
0.64
41
532
33
436
0.75
0.86
1.2
1.3
254.00
238.56
miu/ml
—
10
185
624
5916
1.08
0.86
2.9
3.3
36.18
38.46
u/l
0.19
576
5584
13
80
1.63
0.84
1.0
1.2
162.58
204.79
iu/ml
0.42
13
80
128
1116
1.16
0.84
1.6
1.8
1.10
1.45
g/l
2.21
119
1024
364
3377
1.09
0.84
1.4
1.5
2.42
2.58
g/l
0.73
232
2060
51
407
1.26
0.84
1.2
1.1
3.25
3.77
—
8
47
77
644
1.20
0.83
1.4
1.3
—
—
—
0
0
226
2049
1.12
0.82
2.2
2.4
136.67
136.70
ug/g
0.00
177
1634
355
3294
1.09
0.82
3.3
3.3
0.81
0.82
mmol/l
0.11
333
3098
25
180
1.39
0.82
1.4
1.5
0.25
0.29
nmol/l
0.24
20
139
41
521
0.78
0.81
1.4
1.5
—
—
—
0
0
13
81
1.61
0.81
1.0
1.1
—
—
—
0
0
42
329
1.28
0.80
3.6
3.8
1.05
1.67
%
0.47
37
293
30
224
1.34
0.80
1.4
1.4
—
—
—
0
0
49
392
1.26
0.80
2.8
2.3
1465.85
6055.65
u/l
1.78
16
160
126
1435
0.87
0.80
1.8
2.0
3.48
3.53
ratio
0.17
89
1139
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
117
1020
1.16
0.78
1.5
1.3
64.73
51.39
au/ml
0.26
11
78
732
7001
1.07
0.78
2.0
1.9
1.41
1.34
mmol/l
1.29
605
5850
62
511
1.22
0.78
1.1
1.3
—
—
—
0
0
30
225
1.34
0.78
1.4
1.4
—
—
—
0
0
42
528
0.79
0.77
1.5
1.5
—
—
—
0
0
676
6453
1.07
0.76
3.2
3.6
2.35
2.35
mmol/l
0.04
615
5836
0
28
0.00
0.76
0.0
1.2
—
—
—
0
0
848
8166
1.07
0.73
3.3
3.1
128.80
140.67
ug/l
0.54
783
7546
23
311
0.74
0.73
1.5
1.4
—
—
—
0
0
272
2513
1.09
0.71
1.5
1.5
—
—
—
0
0
526
4992
1.07
0.70
3.6
3.6
0.01
0.04
estimate
0.71
146
1603
28
212
1.33
0.70
1.3
1.5
—
—
—
0
0
731
7016
1.07
0.70
6.0
5.8
2.99
3.83
ug/l
0.47
644
6328
5
27
1.85
0.68
1.0
1.0
81.40
36.42
iu/ml
—
5
27
45
551
0.81
0.68
1.9
1.8
3.06
5.18
mg/l
1.08
35
415
17
119
1.43
0.67
1.3
2.3
—
—
—
0
0
5
28
1.79
0.66
1.4
1.0
—
—
—
0
0
358
3363
1.08
0.64
3.1
2.7
12.75
12.58
umol/l
0.18
332
3124
404
3814
1.07
0.63
1.3
1.3
2.26
1.77
u/ml
0.25
116
1018
314
2936
1.08
0.63
3.1
2.7
21.93
22.40
%
0.29
288
2736
169
1536
1.11
0.63
3.8
3.9
93.10
93.17
ng/l
0.00
145
1320
20
147
1.36
0.61
1.1
1.3
—
—
—
0
0
89
778
1.15
0.61
1.0
1.1
—
—
—
0
0
89
1015
0.87
0.61
2.0
1.8
1.54
1.52
g/l
0.06
74
891
191
2082
0.91
0.61
4.1
4.3
8.04
19.69
ug/l
1.65
160
1737
68
583
1.17
0.60
1.9
1.7
—
—
—
0
0
290
2712
1.08
0.59
5.8
5.7
1.04
1.04
mmol/l
0.15
270
2504
7
114
0.61
0.58
1.6
1.5
—
—
—
0
0
24
309
0.77
0.57
1.3
1.4
—
—
—
0
0
28
352
0.79
0.56
1.6
1.6
—
—
—
0
0
8
55
1.46
0.56
1.1
1.1
—
—
—
0
0
125
1127
1.12
0.55
2.8
2.5
45.87
20.26
au/ml
1.10
13
100
409
3885
1.07
0.55
2.8
3.1
2.46
2.46
mmol/l
0.09
363
3497
46
387
1.19
0.52
3.9
3.6
23.28
28.68
mg/l
0.56
31
267
21
161
1.31
0.51
1.0
1.4
—
—
—
0
0
21
161
1.31
0.51
1.0
1.4
—
—
—
0
0
21
161
1.31
0.51
1.0
1.4
—
—
—
0
0
9
64
1.41
0.51
1.3
1.3
8.67
9.81
mm/h
—
9
64
26
206
1.27
0.51
1.3
1.4
—
—
—
0
0
103
925
1.12
0.50
1.8
1.9
1.14
2.43
ug/l
1.03
91
819
323
3055
1.07
0.50
1.9
2.1
29.60
29.87
s
0.29
314
2966
14
190
0.74
0.49
2.9
2.7
—
—
—
0
0
14
190
0.74
0.49
1.8
1.7
—
—
—
0
0
28
225
1.25
0.49
1.0
1.1
—
—
—
0
0
15
110
1.37
0.48
1.9
2.1
0.67
0.66
e9/l
0.01
15
104
56
484
1.16
0.48
3.0
3.4
0.81
0.82
nmol/l
0.10
45
400
15
111
1.35
0.46
1.0
1.0
—
—
—
0
0
113
1027
1.11
0.46
1.2
1.2
131.19
134.37
u/ml
0.03
47
384
8
117
0.68
0.46
1.5
1.5
—
—
—
0
0
48
412
1.17
0.45
1.3
1.3
—
—
—
0
0
48
412
1.17
0.45
1.3
1.3
—
—
—
0
0
152
1404
1.09
0.45
2.4
2.7
10.50
10.80
g/l
0.42
143
1291
207
1937
1.08
0.44
2.4
2.6
66.47
69.03
e9/l
0.55
147
1448
30
247
1.22
0.44
1.7
2.4
13.30
20.34
mg/l
—
10
91
205
1919
1.08
0.44
6.4
7.1
11.30
10.64
mmol/l
0.61
196
1840
28
339
0.82
0.43
1.3
1.5
35.03
31.60
g/l
0.73
23
309
11
78
1.41
0.43
2.6
2.8
23.84
21.69
mu/l
0.12
11
71
9
131
0.69
0.43
1.4
1.4
—
—
—
0
0
5
32
1.56
0.42
1.4
1.3
—
—
—
0
0
25
203
1.23
0.42
1.4
1.6
59.50
63.23
%
0.19
16
133
13
96
1.36
0.41
1.0
1.5
—
—
—
0
0
13
96
1.36
0.41
1.0
1.5
—
—
—
0
0
13
96
1.36
0.41
1.0
1.5
—
—
—
0
0
13
96
1.36
0.41
1.0
1.5
—
—
—
0
0
49
562
0.87
0.41
1.3
1.4
326.19
268.60
ug/g
1.27
31
345
204
1915
1.07
0.41
2.1
2.3
0.20
0.20
g/l
0.29
191
1781
0
16
0.00
0.41
0.0
1.8
—
16.56
—
0
9
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
25
304
0.82
0.40
1.4
1.3
—
—
—
0
0
30
250
1.20
0.40
1.1
1.1
—
16.11
—
0
9
45
518
0.87
0.40
2.3
2.4
209.85
198.53
%
0.30
39
495
298
2837
1.06
0.39
1.3
1.3
14.28
11.24
u/ml
0.32
120
1040
13
97
1.34
0.39
1.1
1.1
14.34
16.23
u/ml
—
5
40
0
19
0.00
0.39
0.0
1.2
—
67.32
—
0
19
37
316
1.17
0.39
1.4
1.2
257.79
263.11
u/ml
0.05
24
181
12
159
0.75
0.38
1.4
1.1
—
—
—
0
0
31
366
0.84
0.38
1.5
1.4
—
—
—
0
0
14
181
0.77
0.38
1.3
1.3
13.29
12.40
u/l
0.11
14
164
582
5644
1.04
0.37
5.1
4.7
21.11
21.82
%
0.56
297
2873
35
300
1.17
0.36
1.8
1.9
4.35
4.69
mmol/24h
0.25
29
256
62
555
1.12
0.35
1.3
1.3
—
—
—
0
0
9
124
0.72
0.35
1.3
1.2
—
—
—
0
0
56
499
1.13
0.35
1.3
1.4
27.15
26.46
iu/l
0.06
48
417
32
373
0.86
0.35
1.4
1.4
—
—
—
0
0
192
2032
0.94
0.34
3.7
3.6
—
—
—
0
0
12
156
0.77
0.34
1.0
1.0
—
—
—
0
0
6
45
1.33
0.33
1.7
3.2
4.33
5.18
ug/l
—
6
45
31
265
1.17
0.33
1.6
1.6
55.64
59.01
ug/l
0.18
25
226
55
614
0.89
0.33
1.7
2.0
—
—
—
0
0
6
86
0.70
0.33
1.2
2.3
1202.33
864.96
e6/l
—
6
68
16
198
0.81
0.32
1.3
1.0
6.00
2.75
eliau/ml
—
8
82
549
5340
1.04
0.31
4.5
4.2
0.00
0.00
estimate
1.15
178
1865
201
1909
1.06
0.31
1.4
1.5
—
—
—
0
0
225
2144
1.06
0.31
2.1
2.8
8.06
8.79
umol/l
0.24
197
1901
11
142
0.77
0.30
1.4
1.1
—
—
—
0
0
12
153
0.78
0.30
1.6
1.6
55.80
51.05
ug/l
0.18
12
153
49
438
1.12
0.30
1.5
1.8
191.56
206.62
pmol/l
0.87
43
416
71
775
0.91
0.29
2.2
2.4
10.22
10.49
g/l
0.28
66
695
47
420
1.12
0.29
1.3
1.4
508.45
779.97
e6/l
0.34
40
335
403
4161
0.96
0.29
3.7
3.4
0.90
0.78
ug/l
0.59
275
2826
40
451
0.88
0.29
2.2
2.3
176.01
88.24
ug/min
0.57
24
273
1386
13708
1.03
0.29
23.4
22.2
13.82
13.76
%
0.87
1372
13536
53
478
1.11
0.29
1.2
1.1
—
—
—
0
0
23
270
0.85
0.28
1.3
1.1
—
—
—
0
0
643
6285
1.03
0.28
4.0
3.5
51.51
86.92
e6/l
1.23
515
4890
13
103
1.26
0.28
3.2
3.7
—
—
—
0
0
11
140
0.78
0.28
1.1
1.0
240.00
311.48
ng/l
—
5
90
10
129
0.77
0.28
1.4
1.1
—
—
—
0
0
33
375
0.88
0.27
4.6
5.3
1140.29
860.15
iu/ml
—
7
54
8
64
1.25
0.27
2.0
2.5
0.63
0.60
mmol/l
—
8
64
46
413
1.12
0.27
1.3
1.3
86.21
28.63
e6/l
0.41
38
313
67
729
0.92
0.27
1.7
2.1
—
—
—
0
0
39
347
1.13
0.27
1.4
1.4
—
16.78
—
0
10
35
395
0.88
0.27
1.5
1.5
—
—
—
0
0
22
187
1.18
0.26
1.2
1.1
—
55.14
—
0
14
29
253
1.15
0.26
1.1
1.1
2.23
20.55
au/ml
—
7
61
5
75
0.67
0.25
1.0
2.1
18508.80
27001.72
e6/l
—
5
43
20
235
0.85
0.25
1.4
1.4
278.93
277.73
mosm/kgh2o
0.09
15
171
27
235
1.15
0.25
2.9
7.1
9.13
7.50
mmol/l
0.58
19
197
53
483
1.10
0.25
1.2
1.1
—
—
—
0
0
12
96
1.25
0.24
2.3
3.0
1.33
1.04
%
0.30
12
96
59
641
0.92
0.24
1.8
2.3
0.00
0.00
g/l
-0.00
52
564
5
38
1.32
0.23
1.0
1.3
—
—
—
0
0
273
2639
1.04
0.23
2.1
1.8
—
—
—
0
0
216
2079
1.04
0.22
3.8
3.6
1.99
1.81
mmol/l
0.29
186
1781
44
483
0.91
0.22
1.2
1.2
0.93
0.90
g/l
0.35
44
483
27
238
1.14
0.22
1.3
1.3
0.70
8.10
nmol/l
0.49
27
228
11
135
0.81
0.22
1.4
1.1
—
—
—
0
0
11
135
0.81
0.22
1.4
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
4.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
12
98
1.23
0.21
1.1
1.1
0.45
0.53
ratio
—
7
63
5
43
1.16
0.21
1.0
1.2
35.78
30.86
nmol/l
—
5
36
178
1710
1.04
0.20
2.3
2.2
390.96
379.56
nmol/l
0.37
159
1576
83
882
0.94
0.20
2.1
2.4
3.67
3.76
g/l
0.27
78
807
47
511
0.92
0.20
1.3
1.8
—
—
—
0
0
98
1035
0.94
0.20
1.5
1.8
3.38
3.45
mmol/l
0.25
62
745
42
458
0.92
0.19
1.2
1.1
1.46
1.50
g/l
0.58
42
458
256
2485
1.03
0.18
2.1
1.9
—
—
—
0
0
6
53
1.13
0.18
1.2
1.1
—
—
—
0
0
53
492
1.08
0.18
1.2
1.2
2.01
9.31
u/ml
—
7
74
251
2436
1.03
0.18
8.1
7.8
1.14
0.94
mmol/l
0.37
199
1999
222
2150
1.04
0.18
3.7
3.6
5.81
5.81
kpa
0.01
217
2091
105
1000
1.05
0.18
3.6
3.5
4.39
4.48
pmol/l
0.39
93
881
19
166
1.15
0.18
1.3
1.3
—
—
—
0
0
24
268
0.89
0.17
1.3
1.4
44592.00
84561.00
e6/l
0.42
12
150
27
243
1.11
0.17
1.2
1.2
1.43
3.58
u/ml
—
7
77
11
131
0.84
0.17
1.4
1.1
—
—
—
0
0
8
68
1.18
0.16
2.6
2.8
10.75
10.28
kpa
—
8
68
8
68
1.18
0.16
2.6
2.8
5.61
4.81
kpa
—
8
68
12
141
0.85
0.16
1.1
1.0
24.98
42.66
ng/l
—
6
87
12
141
0.85
0.16
1.1
1.0
604.83
662.76
ng/l
—
6
89
14
162
0.86
0.16
2.1
2.0
0.89
1.49
u/field
—
9
89
14
162
0.86
0.16
1.6
1.5
—
—
—
0
0
8
71
1.13
0.16
1.0
1.5
—
—
—
0
0
8
71
1.13
0.16
1.0
1.5
—
—
—
0
0
252
2454
1.03
0.16
8.1
7.9
5.08
5.09
kpa
0.06
245
2364
252
2455
1.03
0.15
8.1
7.9
12.26
12.06
kpa
0.20
244
2369
32
349
0.92
0.15
1.4
1.4
—
—
—
0
0
8
73
1.10
0.15
1.1
1.1
—
—
—
0
0
8
73
1.10
0.15
1.0
1.5
—
—
—
0
0
84
882
0.95
0.15
2.1
2.4
4.08
4.19
g/l
0.69
78
808
84
882
0.95
0.15
2.1
2.4
7.39
7.44
g/l
0.09
77
806
9
78
1.15
0.15
1.1
1.5
40.68
40.51
g/l
—
9
78
27
245
1.10
0.15
1.6
1.5
—
—
—
0
0
137
1321
1.04
0.15
2.0
1.7
—
—
—
0
0
54
507
1.07
0.15
1.3
1.4
—
—
—
0
0
407
3995
1.02
0.15
1.8
1.8
114373510.02
21950915.70
pmol/l
1.11
327
3312
109
1046
1.04
0.15
1.5
1.5
—
—
—
0
0
75
713
1.05
0.14
1.5
1.6
3.94
7.72
iu/ml
1.55
17
167
9
83
1.08
0.14
1.1
1.1
1916.00
1512.82
miu/ml
—
9
83
347
3401
1.02
0.14
3.3
3.1
1.21
1.24
e6/l
0.05
188
1867
40
429
0.93
0.14
1.4
1.4
—
—
—
0
0
17
191
0.89
0.14
1.7
1.5
—
—
—
0
0
47
441
1.07
0.13
1.7
1.6
—
—
—
0
0
80
764
1.05
0.13
3.4
2.6
—
—
—
0
0
30
276
1.09
0.13
2.3
1.7
36.47
24.55
ug/l
0.31
30
270
30
276
1.09
0.13
1.1
1.1
2.31
2.20
u/ml
0.02
13
154
15
132
1.14
0.13
1.3
1.2
—
—
—
0
0
39
364
1.07
0.13
1.5
1.8
1.01
0.84
nmol/l
0.58
29
301
13
113
1.15
0.13
1.4
1.4
114.25
169.93
pmol/l
1.25
13
113
19
211
0.90
0.13
1.6
1.5
—
—
—
0
0
393
3867
1.02
0.12
1.6
1.7
1.32
1.44
mg/l
0.30
300
3028
28
303
0.92
0.12
1.3
1.4
13339.78
4445.23
e6/l
0.45
18
213
12
137
0.88
0.12
1.5
1.5
—
—
—
0
0
27
249
1.09
0.12
1.6
1.5
0.93
0.95
ratio
0.18
18
163
27
249
1.09
0.12
1.6
1.5
1.02
1.24
ratio
0.78
18
163
27
249
1.09
0.12
1.6
1.5
1.09
1.10
ratio
0.01
18
163
15
168
0.89
0.11
1.3
1.4
13.47
13.80
u/l
0.05
15
158
21
230
0.91
0.11
1.0
1.0
—
—
—
0
0
13
147
0.88
0.11
1.5
1.1
—
138.93
—
0
28
250
2451
1.02
0.11
3.7
4.2
238.24
247.53
u/l
0.59
239
2328
92
949
0.97
0.09
3.9
3.7
1.02
1.02
ratio
0.06
85
873
72
746
0.96
0.09
3.7
3.6
36.17
88.24
u/ml
1.88
72
720
6
54
1.11
0.09
15.5
7.1
63.00
71.22
%
—
6
41
188
1844
1.02
0.08
1.5
1.8
1.53
1.54
%
0.02
163
1576
22
204
1.08
0.08
1.1
1.1
1.91
4.18
—
5
30
6
57
1.05
0.08
1.2
1.1
—
—
—
0
0
6
57
1.05
0.08
1.2
1.1
—
—
—
0
0
5
60
0.83
0.08
1.0
1.4
—
—
—
0
0
39
371
1.05
0.08
1.1
1.2
34.90
50.48
u/ml
—
7
35
5
63
0.79
0.08
1.2
1.1
—
—
—
0
0
142
1450
0.98
0.08
2.5
3.0
67.60
63.03
ml/min/173m2
0.78
63
652
6
73
0.82
0.07
1.2
1.0
—
—
—
0
0
144
1411
1.02
0.07
1.9
2.1
—
—
—
0
0
8
75
1.07
0.07
1.4
1.2
—
—
—
0
0
8
76
1.05
0.07
1.4
2.3
—
—
—
0
0
8
77
1.04
0.07
1.3
1.1
—
—
—
0
0
80
823
0.97
0.07
1.9
2.4
2.95
2.99
g/l
0.18
74
749
13
118
1.10
0.07
2.7
2.2
67.40
161.00
ug/min
—
5
28
43
447
0.96
0.06
1.3
1.2
—
—
—
0
0
9
100
0.90
0.06
1.2
1.4
—
—
—
0
0
67
689
0.97
0.06
2.5
3.2
1.79
3.50
ratio
1.27
43
406
46
444
1.04
0.06
1.9
2.0
2.99
16.77
iu/l
0.54
20
180
44
456
0.96
0.06
1.6
1.6
966.79
1000.64
mu/l
0.06
36
386
222
2195
1.01
0.05
8.3
8.1
95.31
95.53
%
0.19
217
2128
135
1329
1.02
0.05
10.9
9.8
0.57
0.63
%
1.33
135
1319
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
110
0.91
0.05
1.2
1.2
—
—
—
0
0
12
110
1.09
0.05
1.3
2.0
—
—
—
0
0
78
763
1.02
0.05
2.5
3.4
37.21
80.55
mg/l
1.25
71
654
75
767
0.98
0.05
1.9
2.5
0.76
1.17
g/l
0.91
69
660
42
434
0.97
0.05
1.3
1.4
11.14
8.59
u/l
0.52
29
345
21
221
0.95
0.04
1.0
1.1
1.96
1.44
u/ml
—
9
111
49
477
1.03
0.04
2.3
2.3
134.72
127.92
g/l
1.21
39
378
18
170
1.06
0.04
1.2
1.3
390954.29
142427.58
e6/l
—
7
113
23
220
1.05
0.03
2.1
1.5
28.57
31.08
ng/l
0.11
23
220
13
139
0.93
0.03
1.3
1.4
—
275.38
—
0
13
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
73
717
1.02
0.03
4.1
2.8
0.36
0.35
iu/ml
0.16
43
391
10
92
1.09
0.03
2.4
2.8
577.80
1195.63
u/ml
—
10
92
317
3153
1.01
0.02
3.5
3.2
2.10
1.94
e6/l
0.18
156
1609
46
450
1.02
0.02
1.4
1.5
—
—
—
0
0
15
158
0.95
0.02
1.3
1.1
—
—
—
0
0
543
5412
1.00
0.02
3.8
3.4
0.24
0.47
e6/l
4.91
419
4068
20
208
0.96
0.02
1.4
1.6
—
—
—
0
0
137
1381
0.99
0.02
10.6
9.5
1.19
1.29
%
0.79
137
1370
27
278
0.97
0.02
2.9
2.6
29.83
1127.16
u/ml
0.62
27
272
164
1629
1.01
0.02
2.3
2.3
12.62
13.18
nmol/l
0.42
149
1457
43
422
1.02
0.01
1.2
1.1
0.61
0.69
ratio
—
6
55
131
1302
1.01
0.01
1.9
2.0
—
—
—
0
0
56
567
0.99
0.01
1.6
1.6
—
—
—
0
0
12
114
1.05
0.00
1.0
2.2
—
—
—
0
0
12
114
1.05
0.00
1.0
2.2
—
—
—
0
0
11
116
0.95
0.00
1.3
1.2
—
—
—
0
0
17
164
1.04
0.00
1.0
1.1
—
—
—
0
0
180
1793
1.00
0.00
2.2
2.6
66.30
66.31
g/l
0.00
168
1649
24
234
1.03
0.00
1.2
1.2
3.00
6.90
u/ml
—
8
111
10
105
0.95
0.00
1.3
1.4
—
—
—
0
0
10
105
0.95
0.00
2.5
2.5
—
—
—
0
0
11
115
0.96
0.00
1.2
1.1
—
—
—
0
0
27
265
1.02
0.00
1.7
1.5
—
—
—
0
0
12
116
1.03
0.00
1.2
1.1
—
—
—
0
0
27
266
1.02
0.00
1.1
1.1
343.60
58.74
iu/ml
—
5
54
76
764
0.99
0.00
2.6
3.4
42.97
126.62
mg/l
0.63
69
654
180
1804
1.00
0.00
2.1
2.5
307.31
39.27
u/l
0.49
150
1513
31
308
1.01
0.00
1.5
1.4
153.08
154.17
au/ml
0.02
13
88
12
117
1.03
0.00
1.2
1.1
—
—
—
0
0
179
1793
1.00
0.00
3.2
3.0
4.53
4.51
kpa
0.04
174
1741
74
743
1.00
0.00
1.5
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.01
—
0
5
0
5
0.00
0.00
0.0
6.2
—
—
—
0
0
0
5
0.00
0.00
0.0
8.4
—
74.80
—
0
5
0
5
0.00
0.00
0.0
1.0
—
1745.20
—
0
5
5
53
0.94
0.00
2.0
1.7
16.42
14.55
pmol/l
—
5
43
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.79
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
77
0.91
-0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
98
0.92
-0.00
1.6
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
2.04
—
0
7
5
50
1.00
-0.00
1.0
1.2
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.2
0.33
0.28
g/l
—
5
39
6
63
0.95
-0.00
1.0
1.2
—
—
—
0
0
5
52
0.96
-0.00
1.2
1.2
107.00
107.30
%
—
5
44
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
2.67
—
0
9
8
82
0.98
-0.00
1.4
1.2
—
—
—
0
0
22
220
1.00
-0.00
2.4
3.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_CHOLEASTOMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_CHOLEASTOMA | 1.047 [0.94, 1.16] | 0.395 |
| Birth year | 0.997 [0.99, 1.01] | 0.45 |
During the follow-up period (1.1.1998 — 31.12.2019), 785 out of 4102 females with H8_CHOLEASTOMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_CHOLEASTOMA | 1.029 [0.93, 1.14] | 0.572 |
| Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 1025 out of 5237 males with H8_CHOLEASTOMA died.
Mortality risk
Mortality risk for people of age
years, who have H8_CHOLEASTOMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.193% |
| 5 | 0.634% | 1.217% |
| 10 | 1.682% | 3.257% |
| 15 | 3.035% | 6.167% |
| 20 | 5.517% | 10.486% |
Relationships between endpoints
↥Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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