cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleNone |
519870 |
2. Check conditionsNone |
519870 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2055 |
4. Check minimum number of eventsNone |
2055 |
5. Include endpointsNone |
2055 |
6. Filter based on genotype QC (FinnGen only) |
1971 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H65-H75
- Name in latin
- Cholesteatoma auris mediae
Similar endpoints
↥List of similar endpoints to
Cholesteatoma of middle ear
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17391 | 7390 | 9876 |
| Only index persons | 15196 | 6641 | 8555 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.21 | 0.28 |
| Only index persons | 0.29 | 0.24 | 0.33 |
| Median age at first event (years) | |||
| Whole population | 46.07 | 49.35 | 43.53 |
| Only index persons | 44.52 | 48.24 | 41.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1971 | 874 | 1097 |
| Unadjusted period prevalence (%) | 0.42 | 0.31 | 0.50 |
| Median age at first event (years) | 49.33 | 47.84 | 50.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2055
- Matched controls
- 20550
TimeCodeWAS
↥TODO / Current known limitations:
- Only showing the top 300 codes, because showing all (sometimes 20k) makes the page too slow.
- Legend / how to read the glyphs.
- Show details (e.g. Fisher or Chi-square test, LR+, etc.) when clicking on a row.
- Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
- Download CSV.
- No filters and sorters.
- Limited amount of endpoints (~400) having TimeCodeWAS data.
- Cross-links to Risteys lab test pages for lab test codes.
No TimeCodeWAS data yet for this endpoint. Try one of these:
- AB1_ASPERGILLOSIS
- AB1_CHLAMY_OTHER
- AB1_EARLY_SYPHILIS
- AB1_EARLY_SYPHILIS_WIDE
- AB1_EBV
- AB1_HIV_NOS
- AB1_INFECT_PARASIT_WIDE
- AB1_LATE_SYPHILIS_WIDE
- AB1_LYME_WIDE
- AB1_MUMPS_WIDE
- AB1_OTHER_PROTOZOAL
- AB1_OTHER_SPIROCHAETAL
- AB1_PEDICULOSIS_ACARIASIS_OTHERINFEST
- AB1_PEDICULOSIS_AND_PHTHIRIAASIS_WIDE
- AB1_PNEUMOCYSTOSIS
- AB1_SEPSIS_BACT_IMPL_WIDE
- AB1_SEPSIS_PARAS_IMPL
- AB1_SEQULAE_POLIO
- AB1_SEXUAL_TRANSMISSION_NOS
- AB1_STREPTO_SEPSIS
- AB1_SYPHILIS_NOS_WIDE
- AB1_TICK_BORNE_ENCEPHALITIS
- AB1_TICK_BORNE_ENCEPHALITIS_WIDE
- AB1_TOXOPLASMOSIS_WIDE
- AB1_VARICELLA
- AB1_VIRAL_HEPATITIS
- AB1_VIRAL_INOTHER_WIDE
- AB1_YAWNS
- AD_U
- AMN2
- ANY_CANC
- ANY_REIMB
- ASTHMA_NOS
- ASTHMA_PNEUMONIA_AND_SEPSIS
- AUD
- C3_ACCESSORY_SINUS_WIDE
- C3_AML_WIDE
- C3_BASAL_CELL_CARCINOMA
- C3_BASEOFTONGUE_WIDE
- C3_CHONDROSARCOMA
- C3_COLORECTAL
- C3_COLORECTAL_ADENO
- C3_DIGESTIVE_ORGANS_NAS
- C3_EYE_BRAIN_NEURO_WIDE
- C3_FOLLICULAR_LYMPHOMA
- C3_GASTRINT_STROM
- C3_LIVER_INTRAHEPATIC_BILE_DUCTS_WIDE
- C3_MANTLE_CELL_LYMPHOMA_WIDE
- C3_NONFOLLICULAR_LYMPHOMA
- C3_NSCLC_ADENO
- C3_NSCLC_SQUAM
- C3_PENIS_WIDE
- C3_RENAL_CELL_CARCINOMA
- C3_SALIVARYNAS_WIDE
- C3_SCLC
- C3_SMALL_INTESTINE_ADENO
- C3_TESTIS
- C3_TONGUENAS_WIDE
- C3_UNCERTAIN_SECONDARY
- C3_URETER
- C3_URETER_WIDE
- CD2_BENIGN_BRAIN_CNS
- CD2_BENIGN_BRONCHUS_LUNG
- CD2_BENIGN_CONNSOFT_NOS
- CD2_BENIGN_CONNSOFT_UPPERLIMB
- CD2_BENIGN_DESCENDING_COLON
- CD2_BENIGN_ENDOCRINE_OTH
- CD2_BENIGN_HEAMANGIOMA_LYMPHANGIOMA
- CD2_BENIGN_MELANOCYTIC_EAR
- CD2_BENIGN_MELANOCYTIC_LOWERLIMB
- CD2_BENIGN_MENINGES_SPINAL
- CD2_BENIGN_OESOPHAGUS
- CD2_BENIGN_OROPHA_OTHER
- CD2_BENIGN_PROSTATE
- CD2_BENIGN_RETROPERITONEUM_PERITONEUM
- CD2_BENIGN_SKIN_EYELID
- CD2_INSITU_BREAST_NOS
- CD2_INSITU_LARYNX
- CHIRBIL_NAS
- CHRONHEP_NAS
- COLITCOLLAG
- COLITENTER
- C_STROKE
- D3_ANAEMIA_B12_DEF
- D3_BLOODNAS
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
- D3_COMBIMMUDEF
- D3_COMPLEMENTDEF
- D3_HEREDFVIIIDEF
- D3_HYPERSPLENISM
- D3_NEFELOF
- D3_NONAIHA_OTHER
- D3_SCNDPOLYCYTHAEMIA
- D3_SICKLECELLDIS
- D3_SIDEROANAEMIAHERED
- D3_THALASSAEMIA
- D3_THROMBOCYTOPENIANAS
- DM_RETINOPATHY_EXMORE
- DRY_AMD_EARLY
- E4_ADDISON
- E4_ADRENAS
- E4_AMYL_ORGAN
- E4_CONGENITAL_HYPOTHYROIDISM_WITHOUT_GOITER
- E4_DIABINSIPIDUS
- E4_DM1
- E4_ENDONUTRMET
- E4_GRAVES_STRICT
- E4_IDIOPATHIC_HYPERCALCIURIA
- E4_IRON_MET
- E4_LACTOSEINT
- E4_MARASMUS
- E4_MINERAL_MET
- E4_NUTRIDEF
- E4_PHOS_MET
- E4_PITUDISNAS
- E4_PLASMAPROT
- E4_PORBILIRNAS
- E4_PUBDISNAS
- E4_SHORT
- E4_SHORT_STATURE_STARTING_BEFORE_BIRTH
- E4_TESTICDYSNAS
- E4_THYCRISIS
- E4_THYMUSDISNAS
- EPISEIZALCO
- F5_EATOTH
- F5_EMOPER
- F5_KELAMENT
- F5_MENTORG
- F5_MILDRET
- F5_PERSMOOD
- F5_PERSOCHANGE
- F5_SCHIZOAFF
- F5_SCHZPHR
- F5_SEDAHYP
- F5_SEVRET
- F5_SPEECH
- F5_STIMUL
- FG_OTHHEART
- G6_ALZHEIMER
- G6_CEROEDEMA
- G6_CLUSTHEADACHE_STRICT
- G6_HCOTHUNS
- G6_MENINGVIR
- G6_MONONPOTHUS
- G6_MYOTDIS
- G6_NEUATR
- G6_NMO
- G6_PARDIPLE
- G6_POLYNEU
- G6_POSTVIRFAT
- G6_POSTZOST
- G6_SCIALE
- GASTRO_OPERATIONS
- GE
- GE_MODE
- GLP1ANA
- H7_BCKRNDRETINOPAT
- H7_BINOCUMOVOTH
- H7_CHOROIDRETINA
- H7_CHORSCAR
- H7_CONJUNCTIVITIS
- H7_CONJUNCTIVITISACUNONATOPIC_WIDE
- H7_EYELIDINFLAMMATION
- H7_EYELIDINFLAMMATION_WIDE
- H7_GLAUCCLOSEPRIM
- H7_GLAUCPRIMOPEN
- H7_LENS
- H7_NYSTAGMUS
- H7_OTHENDOPHTHALMITIS
- H7_OTHERCONJ
- H7_POSTOPEYENAS
- H7_RETINANAS
- H7_VISDISTNAS
- H7_VITRBODYGLOBE
- H8_BPV
- H8_EXCESSIVE_EARWAX
- H8_EXT_MALIGN
- H8_HL_DEAFMUT
- H8_HL_NAS
- H8_MENIERE
- H8_OTIMEDNAS
- HEPATITIS_ACUTE_OTHER_VIRAL
- HERING_UNILATERAL
- HLP_C3_AML
- HLP_C3_ASTROCYTOMA
- I9_ANGIO
- I9_CARDMYOALC
- I9_CARDMYOHYP
- I9_CEREBDOTH
- I9_CONDUCTIO
- I9_HEARTFAIL_EXMORE
- I9_HYPTENSESS
- I9_HYPTENSPUL
- I9_HYPTENSRD
- I9_OTHILLHEART
- I9_PULMEMB
- I9_SAHANEUR
- I9_THROMBANG
- I9_VARICVEOES
- ILD_ENDPOINTS
- ILD_HOSPITAL_PULM_INFECT
- INCREASEDMUSCLETONE
- INSULIN_SHORTFAST
- INTERSTITIAL_CYSTIT_CHRONIC
- J10_ARDS
- J10_ASTHMA_EXMORE
- J10_CHRONRHINITIS
- J10_COPDNAS_INCLAVO
- J10_EXTERLUNG
- J10_INFLUPNEU
- J10_LOWERINF
- J10_PNEUMOBACT
- J10_PULMEOS
- J10_RESPDISOTH
- K11_ALCGASTR
- K11_APPENDECTOMY
- K11_APPENDOTH
- K11_CD_STRICT2
- K11_CHOLANGI
- K11_CHOLELITH
- K11_CONSTIPATION
- K11_EMBIMPACT_TEETH
- K11_FISSANAL
- K11_GIDISEASES
- K11_HYPOPLASIA_ENAMEL_INCLAVO
- K11_MAXIL_CANINE_OPER
- K11_MAXIL_CANINE_PALAT
- K11_MIH_CARIES
- K11_ORALCYST
- K11_OTHILEUS
- K11_PERIODONTAL_NOS
- K11_PULP_PERIAPICAL_INCLAVO
- K11_UC_STRICT2
- K11_ULCER
- K11_UMBHER
- KRA_PSY_CHILDOTH
- KRA_PSY_DEVWIDE
- KRA_PSY_EATING
- KRA_PSY_MOTOR_EXMORE
- KRA_PSY_SPEELING
- KRA_PSY_SPEELING_EXMORE
- L12_ACANTHNIGRICANS
- L12_ATROPHICSKIN
- L12_CHLOASMA
- L12_DERM_NAS
- L12_ERYTHEMANODOSUM
- L12_HAIRLOSS_SCARNAS
- L12_HYPERTRICHOSIS
- L12_INFECT_DERM
- L12_INTERNALSUBSTANCEDERM
- L12_OTHERSKINSUBCUTIS
- L12_PSORI_PUSTGEN
- L12_PSORI_VULG
- M13_ARTHROSIS_OTH
- M13_BURSELBOWOTH
- M13_CARTILAGE
- M13_DEFORMACQ
- M13_DEQUERVAIN
- M13_DERMATOMYOTH
- M13_DISSYNOTENDNAS
- M13_EARLY_LUMBAR_PROLAPSE
- M13_JUVERHEU
- M13_KNEEDERANGEMENTS
- M13_KNUCKLEPADS
- M13_OSTEOCHONDRO
- M13_OSTEOMYELITIS
- M13_OTERSPECARTHR
- M13_PROGRESSIVE_SYSTEMIC_SCLEROSIS
- M13_RELAPSPOLYCHONDR
- M13_SHOULDERBURSITIS
- M13_SPONDYLINFLAMNAS
- M13_SPONTRUPTSYNOTEND
- M13_SYSTCONNECT
- M13_SYSTSLCE
- M13_THORACISPINEPAIN
- M13_TIBIALCOLLATERAL
- M13_VERTEBCOLLAPSE
- MNMED_RILUZOLE
- N14_BARTHOABSCESS
- N14_CALCULOWER
- N14_ENDOMET_INFERT
- N14_FEMALEGENNONINF
- N14_MEMBRANOUS_NEPHROPATHY
- N14_MESNRUIRREG
- N14_OTHFEMPELINF
- N14_OTHNONINFVAG
- N14_PROSTHYPERPLA
- N14_URETHRITISANDURSYNDR
- N14_UTER_POLYP
- N14_VULVAL_HSIL
- O15_ANTEPART_HAEM_NAS
- O15_CONCEPT_ABNORM
- O15_DELIV_SPONT
- O15_ICP
- O15_PREG_BIRTH_PUERP
- O15_PRE_OR_ECLAMPSIA
- OFFICIAL_TILASTOKESKUS_DEATH
- OPER_JFB31
- PD2ND_EXMORE
- PDMED_PERGOLIDE
- PD_DEMENTIA_EXMORE
- PNEUMO_SEPTHICHE
- Q17_ASD
- Q17_AVSD
- Q17_CLEFT_HARD_PALATE_NOS
- Q17_CLEFT_LIP_CLEFT_PALATE
- Q17_CLEFT_PALATE
- Q17_CONGENITAL_PTOSIS
- Q17_CONGENITAL_VESICOURETERAL_REFLUX
- Q17_CONGEN_ICHTHYOSIS
- Q17_CONGEN_MALFO_LUNG
- Q17_CONGEN_MALFO_MUSCULOS_SYSTEM_NOT_ELSEW_CLASSIFIED
- Q17_CONGEN_MALFO_OESOPHAGUS
- Q17_CYSTIC_DISEASE_OF_LIVER
- Q17_CYSTIC_KIDNEY_DISEA_WIDE
- Q17_ECTOPIC_TESTIS
- Q17_FAMILIAL_BENIGN_PEMPHIGUS
- Q17_FOLLICULAR_KERATOSIS_WIDE
- Q17_HYPOSPADIAS
- Q17_NEUROFIBROMATOSIS_1
- Q17_OSTEOGEN_IMPERFECTA
- Q17_OTHER_CONGEN_MALFO_BRAIN
- Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM
- Q17_OTHER_CONGEN_MALFO_INTEG_WIDE
- Q17_OTHER_CONGEN_MALFO_INTESTINE_WIDE
- Q17_OTHER_CONGEN_MALFO_WIDE
- Q17_REDUCT_DEFECTS_LOWER_LIMB
- Q17_SUPERNUMERARY_URETER
- Q17_TUBEROUS_SCLEROSIS
- R18_ABNORMAL_FINDI_EXAMI_BLOOD_WO_DIAGNOSIS
- R18_ABNORMAL_FINDI_EXAMI_URINE_WO_DIAGNOSIS
- R18_ABNORMAL_FINDI_NIPPLE_DISCH_SYNOVIAL_FLUID_WOUND_SECRE
- R18_DISTU_SMELL_TASTE
- R18_ENLARGED_LYMPH_NODES
- R18_OTHER_ABNORMALITI_PLASMA_PROTEINS
- R18_OTHER_SYMPTOMS_SIGNS_INVOLVI_COGNITIVE_FUNCTIONS_AWARE
- R18_OTHER_SYMPTOMS_SIGNS_INVOLVI_GENERAL_SENSA_PERCEP
- R18_OTHER_SYMPTOMS_SIGNS_INVOLVI_URINARY_SYSTEM
- R18_RASH_OTHER_NONSPECIFIC_SKIN_ERUPT
- R18_SYMPTOMS_SIGNS_CONCERNI_FOOD_FLUID_INTAKE
- R18_SYMPTOMS_SIGNS_INVOLVI_COGNITION_PERCEP_EMOTIONAL_STATE_BEHVI
- R18_SYMPTOMS_SIGNS_INVOLVI_URINARY_SYSTEM
- R18_UNSPE_HAEMATU
- RHEUMA_OTHER_WIDE
- RX_ASTMA_BIOL
- RX_CROHN_2NDLINE
- RX_GLUCOSAMINE
- RX_L01XE
- RX_OPIOIDS
- RX_TRAMADOL
- SPONDYLOARTHRITIS
- ST19_BURNS_CORROSIO_MULTIPLE_UNSPE_BODY_REGIONS
- ST19_BURN_CORROSION_ANKLE_FOOT
- ST19_BURN_CORROSION_BODY_REGION_UNSPE
- ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT
- ST19_BURN_CORROSION_OTHER_INTERNAL_ORGANS
- ST19_BURN_CORROSION_WRIST_HAND
- ST19_COMPLICATIO_PECUL_REATTACHM_AMPUT
- ST19_EFFEC_OTHER_DEPRI
- ST19_FOREI_BODY_RESPI_TRACT
- ST19_FRACT_LOWER_LEG_INCLU_ANKLE
- ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS
- ST19_INJURI_THORAX
- ST19_INJURY_BLOOD_VESSE_LOWER_LEG_LEVEL
- ST19_INJURY_NERVES_LUMBAR_SPINAL_CORD_ABDOMEN_LOWER_BACK_PELVIS_LEVEL
- ST19_INJURY_POISO_CERTA_OTHER_CONSE_EXTER_CAUSES
- ST19_OPEN_WOUND_ANKLE_FOOT
- ST19_OTHER_INJURI_LOWER_LIMB_LEVEL_UNSPE
- ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT
- ST19_OTHER_UNSPE_INJURI_LOWER_LEG
- ST19_POISO_MEDICI_ADVERSE
- ST19_SEQUEL_INJURI_NECK_TRUNK
- ST19_SUPERF_INJURY_HIP_THIGH
- ST19_SUPERF_INJURY_NECK
- ST19_TRAUMAT_SUBAR_HAEMORRHAGE
- T1D_WIDE2
- T2D
- THYGROWTHS
- TRIPTAN1
- VWXY20_DIVING_JUMPI_WATER_CAUSI_INJURY_OTHER_DROWN_SUBME
- VWXY20_INTENTI_SELF_H_JUMPI_LYING_MOVING_OBJECT
- VWXY20_JAAMI_PURISTUK_TAI_MURSK_JOUTU_ESINEI_SISAAN_TAI_VALIIN
- VWXY20_LIFESTYLE__CONDI
- VWXY20_MOTOR_NONMOTOR__ACCIDENT_TYPE_VEHIC_UNSPE_NONTRAF_ACCIDENT
- VWXY20_OCCUPANT_HEAVY_TRANSPO_VEHIC_INJURED_OTHER_UNSPE_TRANSPO_ACCIDENTS
- VWXY20_OTHER_FACTOR_ENVIRONMENT
- VWXY20_PEDES_INJURED_COLLIS_W_OTHER_NONMOTOR_VEHIC
- VWXY20_PEDES_INJURED_COLLIS_W_PEDAL_CYCLE
- VWXY20_STERI_VAROT_PETTA_KIRURGISEN_TAI_MUUN_LAAKETIETEELLISEN_HOIDON_AIKANA
- Z21_FAMILY_HISTORY_OTH_SPECIFIC_DISORD
- Z21_NEED_IMMUNI_OTH_SINGLE_VIRAL_DISEA
- Z21_NEED_IMMUNI_SINGLE_BACTERIAL_DISEA
- Z21_OTHER_ORTHOPA_FOLLOW__CARE
- Z21_PERSONS_ENCOUNTERI_HEALTH_SERVI_CIRCUMSTANC_RELATED_REPRODUCTION
- Z21_PROBL_RELATED_CARE__DEPENDENCY
- Z21_PROCREATIVE_MANAG
- Z21_TOBAC_USE
- Z21_UPPER_ARM
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint H8_CHOLEASTOMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_CHOLEASTOMA | 1.047 [0.94, 1.16] | 0.395 |
| Birth year | 0.997 [0.99, 1.01] | 0.45 |
During the follow-up period (1.1.1998 — 31.12.2019), 785 out of 4102 females with H8_CHOLEASTOMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_CHOLEASTOMA | 1.029 [0.93, 1.14] | 0.572 |
| Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 1025 out of 5237 males with H8_CHOLEASTOMA died.
Mortality risk
Mortality risk for people of age
years, who have H8_CHOLEASTOMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.193% |
| 5 | 0.634% | 1.217% |
| 10 | 1.682% | 3.257% |
| 15 | 3.035% | 6.167% |
| 20 | 5.517% | 10.486% |
Relationships between endpoints
↥Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear
GWS hits: -