Acute myringitis

H8_MYRINGACU

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H73.0
  • Hospital discharge: ICD-9 3840
  • Cause of death: ICD-10 H73.0
  • Cause of death: ICD-9 3840

2 out of 7 registries used, show all original rules.

308

4. Check minimum number of events

None

308

5. Include endpoints

None

308

6. Filter based on genotype QC (FinnGen only)

272

Control definitions (FinnGen only)

Control exclude
H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H73
Name in latin
Myringitis acuta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3427 1705 1712
Only index persons 2624 1359 1265
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.05
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 11.72 13.87 9.40
Only index persons 19.24 21.74 16.56

-FinnGen-

Key figures

All Female Male
Number of individuals 272 173 99
Unadjusted period prevalence (%) 0.06 0.06 0.05
Median age at first event (years) 41.81 37.30 49.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
285
Matched controls
2850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H73.0
ICD-10 Finland
Acute myringitis
10277.3
307.7
270
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
14.3
96.7
108
117
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
+∞
48.3
45
*
H66.9
ICD-10 Finland
Otitis media, unspecified
8.6
46.8
69
102
UDC00
NOMESCO Finland
Ear microscopy
8.4
42.6
63
93
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
60.4
32.2
37
7
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
123.9
31.4
33
*
H65.2
ICD-10 Finland
Chronic serous otitis media
+∞
26.5
25
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
99.1
25.1
27
*
H92.0
ICD-10 Finland
Otalgia
6.1
24.9
48
92
H60.9
ICD-10 Finland
Otitis externa, unspecified
5.0
21.7
53
125
DCD00
NOMESCO Finland
Myringoplasty
+∞
19.0
18
*
H65.0
ICD-10 Finland
Acute serous otitis media
24.8
18.1
25
11
DFF00
NOMESCO Finland
Pure tone audiometry
4.3
16.4
47
125
H01
ICPC
Ear pain/earache
3.4
16.4
70
246
3840A
ICD-9 Finland
Other disorders of tympanic membrane, Acute myringitis without mention of otitis media
+∞
15.8
15
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
15.8
15
*
S02CA02
ATC
flumetasone and antiinfectives; otic
5.6
14.2
28
54
DC1AD
NOMESCO Finland
Temporalbone CT
56.3
14.0
16
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.3
13.3
58
205
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
52.5
13.0
15
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
+∞
12.6
12
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
12.6
12
*
4122
FHL
Tympanostomy (tympanic tube)
124.8
11.5
12
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
29.3
10.8
14
5
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.4
10.8
182
1221
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
10.5
10
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.4
10.3
103
552
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
41.6
10.0
12
*
DFF15
NOMESCO Finland
Speech audiometry
5.1
9.7
21
44
H60.8
ICD-10 Finland
Other otitis externa
5.2
9.5
20
41
M54.5
ICD-10 Finland
Low back pain
2.1
8.8
121
730
H60.3
ICD-10 Finland
Other infective otitis externa
7.3
8.7
20
29
TDA90
NOMESCO Finland
Removal wax from ear
13.3
8.5
14
11
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
8.4
8
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
8.2
124
770
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
22.8
8.1
11
5
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
7.4
82
450
H60
ICD-10 Finland
Otitis externa
3.4
7.3
27
85
M54.4
ICD-10 Finland
Lumbago with sciatica
2.3
7.3
64
319
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
8.3
7.2
15
19
J01CA04
ATC
amoxicillin; systemic
2.8
7.2
255
2138
J01DA08
ATC
[U] cefaclor
2.6
7.1
46
199
DAX08
NOMESCO Finland
Fitting of hearing aid
3.6
6.9
23
68
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
6.8
68
357
R01AD09
ATC
mometasone; nasal
1.9
6.7
143
982
4451
FHL
Guitar cutting
6.2
6.7
17
29
H29
ICPC
Ear symptom/complaint other
2.5
6.6
44
193
H02AB06
ATC
prednisolone; systemic
1.9
6.3
131
887
ZZG00
NOMESCO Finland
Graft of cartilage
+∞
6.3
6
*
H73.8
ICD-10 Finland
Other specified disorders of tympanic membrane
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
74
270
3.35
16.33
2.3
1.5
—
—
—
0
0
65
332
2.24
6.95
2.4
1.9
—
—
—
0
0
178
1420
1.68
4.21
6.0
5.7
6.47
6.57
mmol/l
0.20
169
1309
91
610
1.72
4.18
4.3
4.0
—
—
—
0
0
52
297
1.92
4.03
1.7
1.3
—
—
—
0
0
15
50
3.11
3.74
3.7
7.0
1.14
1.22
mmol/l
0.21
15
43
150
1169
1.60
3.71
3.6
2.8
—
—
estimate
—
0
0
136
1043
1.58
3.55
8.1
7.6
1.20
1.21
mmol/l
0.96
126
972
102
740
1.59
3.33
3.2
2.7
61.00
70.81
u/l
0.32
91
693
76
517
1.64
3.21
2.7
2.5
7.02
7.32
e6/l
0.04
65
471
165
1345
1.54
3.15
3.8
3.7
0.00
0.00
estimate
-0.00
30
269
12
36
3.43
3.05
3.1
7.2
102.17
104.52
mmol/l
0.80
12
31
12
36
3.43
3.05
3.1
7.2
11.92
10.52
mmol/l
1.33
12
31
108
808
1.54
3.03
3.6
2.3
—
—
—
0
0
162
1327
1.51
2.94
3.7
3.6
0.00
0.00
estimate
-0.00
31
293
101
749
1.54
2.93
8.2
6.5
—
—
—
0
0
163
1340
1.51
2.89
3.7
3.6
0.00
5.54
estimate
0.50
29
293
144
1154
1.50
2.89
9.9
8.0
1.21
1.21
mmol/l
0.47
128
1006
92
671
1.55
2.87
4.2
3.0
0.40
0.44
e6/l
0.06
65
474
135
1075
1.49
2.75
3.4
3.3
6.31
6.28
ph
0.13
70
598
6
10
6.10
2.71
2.0
1.1
—
—
—
0
0
70
486
1.58
2.69
1.6
1.3
39.22
29.89
iu/ml
0.21
21
149
11
35
3.23
2.67
2.6
1.5
—
—
—
0
0
201
1742
1.52
2.65
3.5
3.3
39.96
42.35
u/l
0.29
190
1659
24
123
2.04
2.54
7.9
14.1
16.77
15.92
%
0.92
24
117
112
870
1.47
2.54
9.2
7.0
—
—
—
0
0
13
51
2.62
2.48
1.0
1.2
3.40
2.63
u/ml
—
5
27
16
70
2.36
2.46
3.6
5.2
1.01
0.90
%
0.61
16
63
85
628
1.50
2.45
3.0
2.4
2.35
2.81
mg/l
1.61
77
550
5
8
6.34
2.38
1.6
1.4
—
—
—
0
0
63
439
1.56
2.37
3.1
2.8
577.25
539.87
mosm/kgh2o
0.52
52
386
20
99
2.10
2.32
1.6
1.7
—
—
—
0
0
103
799
1.45
2.31
4.0
3.5
714.26
32.95
ng/l
0.48
63
509
30
173
1.82
2.28
1.3
1.2
—
—
—
0
0
63
443
1.54
2.27
1.5
1.3
18.67
9.36
u/ml
0.29
22
186
121
970
1.43
2.27
15.4
11.4
1.24
1.19
inr
0.54
104
789
101
788
1.44
2.18
4.2
3.1
24.82
126.66
e6/l
0.64
73
590
82
617
1.46
2.13
1.7
1.8
—
—
—
0
0
72
530
1.48
2.09
3.2
2.1
1.15
1.19
mg/l
0.05
58
416
120
974
1.40
2.05
2.3
2.0
101.89
96.22
pmol/l
0.90
74
510
48
325
1.57
2.04
3.1
2.6
29.19
29.35
s
0.07
48
317
201
1784
1.43
2.01
12.2
8.0
79.76
78.59
u/l
0.15
195
1683
47
319
1.57
1.98
3.6
2.9
4.22
5.01
e9/l
0.50
42
284
7
21
3.39
1.97
1.0
1.0
—
—
—
0
0
10
39
2.62
1.96
1.0
1.4
—
—
—
0
0
10
39
2.62
1.96
1.0
1.4
—
—
—
0
0
10
39
2.62
1.96
1.0
1.4
—
—
—
0
0
10
39
2.62
1.96
1.0
1.4
—
—
—
0
0
5
11
4.60
1.95
2.6
3.4
—
—
—
0
0
30
182
1.72
1.94
2.9
4.5
7.34
7.35
ph
0.07
20
128
86
664
1.42
1.93
5.0
4.2
10.45
8.89
mg/mmol
0.15
56
420
85
655
1.42
1.93
4.4
3.5
79.69
54.76
mg/l
0.27
55
430
76
974
0.70
1.90
3.0
2.9
—
—
—
0
0
55
391
1.50
1.88
4.5
2.9
2.98
2.61
e6/l
0.11
23
179
78
595
1.43
1.87
3.2
3.5
1.02
1.02
kg/l
0.05
56
380
5
12
4.22
1.83
1.2
1.8
63.80
68.83
umol/l
—
5
12
41
276
1.57
1.79
1.4
1.4
—
—
—
0
0
169
1472
1.36
1.79
12.8
10.4
4.09
3.99
e9/l
0.22
151
1273
261
2461
1.72
1.78
22.2
13.8
26.26
22.79
mg/l
0.71
227
1965
16
291
0.52
1.77
1.4
1.4
—
—
—
0
0
6
18
3.38
1.75
7.5
1.6
2.77
3.72
mg/l
—
6
18
83
647
1.40
1.75
1.8
1.6
20.68
20.58
nmol/l
0.02
74
562
97
778
1.37
1.72
4.3
3.2
7.48
8.11
mmol/l
0.66
86
668
150
1288
1.35
1.72
4.0
3.2
108.03
96.07
ug/l
0.16
143
1221
19
105
1.87
1.67
1.4
1.3
—
1.63
—
0
6
8
31
2.63
1.67
2.6
1.7
896.25
1261.60
e6/l
—
8
20
8
31
2.63
1.67
1.3
1.7
—
—
—
0
0
31
199
1.63
1.65
8.1
13.7
24.44
24.78
mmol/l
0.31
31
199
29
184
1.64
1.62
3.7
4.8
7.42
7.41
ph
0.29
22
146
55
407
1.44
1.55
1.7
1.6
—
—
—
0
0
5
15
3.37
1.53
1.4
1.1
—
—
—
0
0
77
607
1.37
1.51
4.0
3.4
—
0.00
—
0
6
278
2698
2.24
1.48
32.0
21.5
261.38
256.17
e9/l
0.56
273
2646
15
80
1.92
1.47
3.7
4.9
1.59
1.55
%
0.08
15
73
50
372
1.42
1.37
1.4
1.4
750.77
504.00
titre
0.45
13
85
5
17
2.97
1.36
1.2
1.0
—
—
—
0
0
278
2702
2.17
1.36
31.6
21.5
7.17
6.75
e9/l
1.33
271
2641
54
408
1.40
1.36
5.7
3.3
28.44
287.49
ng/l
2.37
35
286
278
2701
2.19
1.36
31.6
21.4
4.52
4.52
e12/l
0.06
272
2644
9
42
2.18
1.35
1.0
1.4
—
—
—
0
0
69
544
1.35
1.34
5.2
3.0
334.97
334.26
umol/l
0.02
58
485
142
1240
1.29
1.33
9.2
6.7
12.44
12.32
umol/l
0.02
135
1172
61
473
1.37
1.32
1.8
1.9
—
—
—
0
0
5
18
2.81
1.29
10.6
3.6
—
—
—
0
0
5
18
2.81
1.29
1.0
1.1
—
—
—
0
0
237
2224
1.39
1.27
4.9
4.5
6.02
5.78
mmol/l
1.45
218
2061
48
360
1.40
1.26
3.9
2.6
2.42
2.36
g/l
0.31
42
335
17
100
1.74
1.26
1.2
1.7
—
18.88
—
0
5
6
25
2.43
1.25
2.8
1.6
254.17
185.13
e6/l
—
6
15
21
132
1.64
1.24
1.1
1.1
—
—
—
0
0
85
699
1.31
1.24
6.7
4.2
7.40
7.39
ph
0.08
63
484
30
206
1.51
1.24
7.7
11.4
124.13
121.16
g/l
0.45
30
201
117
1007
1.27
1.20
3.1
3.5
0.00
0.01
estimate
0.80
25
247
6
26
2.33
1.19
2.8
1.6
364.67
534.93
e6/l
—
6
15
8
39
2.08
1.16
1.1
1.1
—
—
—
0
0
19
119
1.64
1.15
4.5
6.4
25.45
24.66
mmol/l
0.65
19
112
34
244
1.45
1.14
7.5
10.5
7.42
7.42
ph
0.02
20
133
263
2525
1.54
1.14
19.3
12.2
—
—
—
0
0
8
40
2.03
1.13
1.1
1.2
—
—
—
0
0
97
821
1.28
1.13
1.7
1.6
—
—
—
0
0
22
147
1.54
1.04
1.4
1.2
—
—
—
0
0
5
22
2.29
1.04
1.0
1.2
—
—
—
0
0
85
715
1.27
1.03
3.4
2.7
—
—
—
0
0
87
735
1.26
1.02
2.3
2.2
—
—
—
0
0
21
140
1.54
1.00
1.4
1.4
—
—
—
0
0
9
49
1.86
0.99
1.0
1.1
—
—
—
0
0
91
776
1.25
0.98
5.0
3.2
2.33
2.35
mmol/l
1.12
86
716
52
413
1.32
0.97
3.4
2.7
79.65
91.44
ug/g
0.30
43
330
35
261
1.39
0.97
1.5
1.6
1034.40
988.65
mu/l
0.08
30
231
30
218
1.42
0.96
7.9
11.1
97.28
95.54
%
1.54
30
212
43
333
1.34
0.95
4.0
2.7
23.74
23.67
%
0.01
38
317
20
134
1.53
0.94
4.7
5.6
—
—
—
0
0
6
27
2.25
0.94
1.7
2.0
42.17
39.87
%
—
6
27
10
55
1.85
0.93
1.1
1.1
—
—
—
0
0
38
290
1.36
0.92
2.2
1.9
—
—
—
0
0
33
246
1.39
0.92
7.5
10.4
5.19
5.12
kpa
0.23
33
237
33
246
1.39
0.92
7.5
10.3
13.59
12.82
kpa
0.48
33
237
34
256
1.37
0.90
1.1
1.2
—
—
—
0
0
30
221
1.40
0.90
2.9
3.0
0.21
0.22
g/l
0.37
30
210
106
928
1.23
0.89
5.9
3.6
82.15
109.89
e6/l
0.21
76
627
8
43
1.88
0.88
1.0
1.1
—
—
—
0
0
20
137
1.49
0.86
1.5
1.3
205.09
276.11
miu/ml
0.61
11
66
152
1383
1.21
0.86
8.8
7.3
0.20
0.19
e9/l
0.50
136
1226
35
267
1.35
0.86
4.5
5.7
7.38
7.38
ph
0.12
21
155
147
1337
1.21
0.83
8.4
6.9
0.61
0.56
e9/l
1.48
131
1158
147
1338
1.20
0.82
8.4
6.9
0.05
0.04
e9/l
2.32
130
1158
151
1379
1.20
0.81
8.3
6.8
2.44
1.95
e9/l
0.72
138
1229
24
174
1.41
0.80
1.1
1.1
—
—
—
0
0
15
99
1.54
0.77
1.2
1.2
—
—
—
0
0
207
1955
1.21
0.74
4.9
4.5
14.69
14.70
pmol/l
0.02
195
1785
123
1110
1.19
0.73
3.0
2.5
79.57
74.58
nmol/l
1.01
115
1011
16
109
1.50
0.72
3.0
4.6
—
—
—
0
0
5
26
1.94
0.71
2.2
1.7
—
—
—
0
0
5
26
1.94
0.71
5.2
3.0
—
—
—
0
0
86
754
1.20
0.70
2.7
3.1
0.00
0.00
estimate
0.50
25
233
22
162
1.39
0.68
1.9
1.5
18.53
19.59
iu/l
0.08
22
133
225
2154
1.21
0.63
6.5
5.7
39.86
38.70
mmol/mol
0.75
208
2031
10
63
1.61
0.62
3.3
2.9
58.98
59.09
%
—
10
63
17
122
1.42
0.61
10.9
2.6
—
—
—
0
0
8
51
1.58
0.61
1.0
1.1
—
—
—
0
0
22
166
1.35
0.60
8.4
4.5
76.23
73.39
ng/l
0.08
22
151
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
19
140
1.38
0.60
2.3
1.8
—
—
—
0
0
0
22
0.00
0.59
0.0
10.8
—
974.68
—
0
22
238
2298
1.22
0.57
5.9
5.4
1.83
1.86
mu/l
0.17
220
2130
63
548
1.19
0.56
5.6
5.0
1.44
1.92
ug/l
1.13
57
494
6
37
1.63
0.56
1.7
2.2
—
—
—
0
0
36
299
1.23
0.51
7.9
9.9
105.61
104.41
mmol/l
0.98
36
299
26
208
1.28
0.50
4.3
5.3
0.56
1.08
%
—
9
65
261
2551
1.27
0.49
16.5
11.1
27.14
26.15
u/l
0.46
255
2487
50
432
1.19
0.48
1.8
1.6
—
—
—
0
0
26
210
1.26
0.47
3.0
3.6
—
—
—
0
0
11
78
1.43
0.43
2.0
1.4
—
—
—
0
0
5
31
1.62
0.43
1.2
1.5
283.60
283.68
mosm/kgh2o
—
5
22
84
765
1.14
0.42
1.5
1.4
0.64
2.23
u/ml
2.04
18
203
25
204
1.25
0.42
4.5
5.1
0.67
0.81
%
—
9
62
0
17
0.00
0.41
0.0
1.1
—
279.55
—
0
11
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
10
71
1.42
0.39
1.6
1.4
198.80
303.31
ug/g
—
5
37
5
35
1.44
0.39
1.2
1.4
11.70
28.93
ng/l
—
5
35
5
35
1.44
0.39
2.4
2.4
8.34
8.61
kpa
—
5
35
5
35
1.44
0.39
1.2
1.3
—
—
—
0
0
5
35
1.44
0.39
2.6
2.4
5.06
4.78
kpa
—
5
35
23
188
1.24
0.39
5.7
6.2
23.02
23.82
mmol/l
0.74
23
188
22
179
1.25
0.38
2.3
2.4
20764.89
4807.61
u/l
—
9
80
29
244
1.21
0.38
10.5
10.9
—
—
—
0
0
40
348
1.17
0.37
1.9
1.6
1023.98
1188.88
nmol/l
0.62
35
266
34
292
1.19
0.36
1.5
1.3
—
—
—
0
0
103
959
1.12
0.36
2.3
2.0
—
—
—
0
0
6
42
1.44
0.36
1.8
2.6
4.03
6.46
pmol/l
—
6
42
13
100
1.31
0.34
2.5
1.6
42.54
42.28
nmol/l
0.01
13
100
6
45
1.34
0.34
1.2
1.5
189.28
310.26
mu/l
—
6
39
30
257
1.19
0.33
3.5
3.5
1.72
1.81
%
0.23
24
238
80
739
1.11
0.32
3.2
3.6
0.00
0.00
estimate
-0.00
28
274
106
995
1.10
0.32
2.1
2.0
1.50
1.33
mmol/l
1.31
98
856
7
52
1.35
0.31
2.3
2.4
7.43
7.41
ph
—
7
52
23
195
1.20
0.29
4.6
5.4
0.00
0.21
%
—
6
53
8
66
1.22
0.27
1.1
1.1
—
—
—
0
0
8
66
1.22
0.27
1.1
1.1
—
—
—
0
0
17
141
1.22
0.26
1.1
1.1
—
—
—
0
0
222
2169
1.11
0.26
25.1
17.6
13.51
13.45
%
0.30
222
2156
49
446
1.12
0.26
1.6
1.7
178571824.17
10471642.87
pmol/l
0.45
42
382
238
2334
1.12
0.26
5.6
5.1
2.74
2.74
mmol/l
0.00
219
2195
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.6
—
589.20
—
0
5
0
10
0.00
0.21
0.0
1.2
—
6.32
—
0
10
0
12
0.00
0.21
0.0
1.3
—
80.93
—
0
7
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
0.00
—
0
13
0
14
0.00
0.20
0.0
1.3
—
1.56
—
0
14
22
193
1.15
0.20
4.4
3.4
66.66
71.81
e9/l
0.42
16
136
30
270
1.12
0.20
1.6
1.5
—
—
—
0
0
234
2304
1.09
0.18
4.9
4.5
1.40
1.47
mmol/l
1.70
216
2162
28
253
1.12
0.17
1.3
1.5
—
—
—
0
0
11
92
1.20
0.16
1.0
1.4
—
—
—
0
0
8
73
1.10
0.16
9.1
10.1
—
—
—
0
0
6
77
0.77
0.16
1.2
1.3
—
—
—
0
0
33
304
1.10
0.15
1.3
1.2
—
—
—
0
0
22
198
1.12
0.15
1.3
1.3
—
—
—
0
0
18
202
0.88
0.15
1.3
1.6
—
—
—
0
0
18
202
0.88
0.15
1.3
1.6
—
—
—
0
0
7
88
0.79
0.14
1.3
1.2
—
—
—
0
0
14
160
0.87
0.14
1.3
1.5
—
—
—
0
0
10
84
1.20
0.14
1.1
1.3
—
—
—
0
0
10
84
1.20
0.14
1.3
1.1
—
—
—
0
0
9
106
0.84
0.13
2.9
2.4
—
—
—
0
0
9
107
0.84
0.13
1.0
1.1
1.41
1.53
g/l
—
9
107
9
110
0.81
0.13
1.0
1.2
0.96
0.89
g/l
—
9
110
31
334
0.92
0.13
3.0
3.0
0.68
0.77
ug/l
0.17
16
202
234
2312
1.07
0.13
5.1
4.7
4.61
4.65
mmol/l
0.28
217
2178
18
200
0.89
0.13
1.3
1.6
—
—
—
0
0
13
114
1.15
0.12
1.8
1.5
—
—
—
0
0
18
199
0.90
0.12
1.3
1.6
—
—
—
0
0
19
209
0.90
0.11
1.2
1.3
78.37
129.76
u/ml
—
6
81
63
606
1.05
0.10
6.0
5.1
—
—
—
0
0
72
696
1.05
0.09
1.7
1.4
1.90
2.20
g/l
1.29
46
416
13
116
1.13
0.09
1.8
1.6
—
—
—
0
0
215
2173
0.96
0.09
4.2
3.9
1.33
1.25
mmol/l
0.77
198
2033
5
65
0.77
0.08
1.0
1.4
—
—
—
0
0
7
65
1.08
0.08
3.0
8.8
75.93
64.79
%
—
7
65
12
133
0.90
0.08
1.6
1.8
—
—
—
0
0
8
74
1.08
0.07
2.9
1.9
200.00
307.58
ug/l
—
8
67
17
183
0.92
0.06
1.3
1.6
—
—
—
0
0
115
1170
0.97
0.06
12.4
11.3
0.00
0.00
e9/l
0.75
90
952
13
119
1.10
0.06
1.3
1.5
8.13
10.82
u/l
0.58
13
97
10
90
1.12
0.05
1.4
1.9
—
—
—
0
0
13
140
0.93
0.04
1.8
1.7
—
—
—
0
0
10
92
1.09
0.03
10.3
6.8
1.36
1.22
mg/l
—
10
82
13
138
0.94
0.02
1.5
1.4
0.21
0.31
mg/l
—
7
54
21
204
1.03
0.00
4.9
5.9
0.00
0.13
%
—
5
52
21
212
0.99
0.00
2.7
4.7
2.81
8.96
ug/l
2.39
16
172
13
127
1.02
0.00
2.2
6.0
0.58
0.58
%
0.03
13
127
19
187
1.02
0.00
1.2
1.2
—
55.83
—
0
6
21
214
0.98
0.00
1.5
2.0
6.00
6.21
ph
0.65
13
143
31
314
0.99
0.00
14.6
6.7
1.05
1.11
mmol/l
0.63
31
296
0
6
0.00
0.00
0.0
2.3
—
33.67
—
0
6
0
6
0.00
0.00
0.0
24.3
—
0.42
—
0
6
0
6
0.00
0.00
0.0
4.7
—
8.67
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
50.33
—
0
6
6
67
0.89
0.00
1.2
1.8
3.53
3.59
mmol/l
—
6
62
5
58
0.86
0.00
2.0
1.9
—
—
—
0
0
9
96
0.94
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
11441.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
139.40
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
2.2
4.4
—
—
—
0
0
7
78
0.89
-0.00
2.3
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
18.60
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_MYRINGACU and mortality.

Females

Parameter HR [95% CI] p-value
H8_MYRINGACU 1.323 [0.97, 1.81] 0.079
Birth year 0.995 [0.99, 1.0] 0.313

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 1464 females with H8_MYRINGACU died.

Males

Parameter HR [95% CI] p-value
H8_MYRINGACU 1.3 [0.92, 1.83] 0.133
Birth year 0.99 [0.98, 1.0] 0.04

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 1363 males with H8_MYRINGACU died.

Mortality risk

Mortality risk for people of age

years, who have H8_MYRINGACU.

N-year risk Females Males
1 0.129% 0.354%
5 0.737% 1.732%
10 2.045% 4.315%
15 4.011% 8.126%
20 6.719% 13.886%

Relationships between endpoints

Index endpoint: H8_MYRINGACU – Acute myringitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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