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Benign neoplasm of thyroid gland

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_THYROID

thyroid carcinoma: A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D34&
  • Hospital discharge: ICD-9 — 226
  • Hospital discharge: ICD-8 — 2261
  • Cause of death: ICD-10 — D34&
  • Cause of death: ICD-9 — 226
  • Cause of death: ICD-8 — 2261

2 out of 7 registries used, show all original rules.

1381

4. Check minimum number of events

None

1381

5. Include endpoints

None

1381

6. Filter based on genotype QC (FinnGen only)

1247

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Neoplasma benignum glandulae thyreoideae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7907 6229 1639
Only index persons 7326 5875 1451
Unadjusted period prevalence (%)
Whole population 0.15 0.18 0.05
Only index persons 0.18 0.22 0.06
Median age at first event (years)
Whole population 51.68 50.47 56.14
Only index persons 50.64 49.65 54.67

-FinnGen-

Key figures

All Female Male
Number of individuals 1247 966 281
Unadjusted period prevalence (%) 0.29 0.34 0.13
Median age at first event (years) 51.85 49.73 59.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1279
Matched controls
12790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
76.2
307.7
571
134
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
53.9
307.7
296
71
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
11615.8
307.7
1045
*
2260A
ICD-9 Finland
Benign neoplasm of thyroid gland[NEOPLASMA BENIGNUM GLANDULAE THYREOIDEAE]
+∞
243.8
226
*
2504
FHL
Unilateral resection or enucleation
37.3
204.0
128
38
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
18.7
202.5
167
102
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
17.9
195.9
165
105
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
22.0
175.7
133
67
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
9.5
167.7
218
272
H03AA01
ATC
levothyroxine sodium; systemic
4.3
145.5
641
2420
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
19.6
138.8
110
61
104
Kela drug reimbursment
Thyroid insufficiency
6.1
138.7
283
572
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.5
129.8
239
436
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
11.9
124.4
131
121
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
10.9
122.3
138
141
BAA60
NOMESCO Finland
Total thyroidectomy
9.7
111.4
137
157
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
12.4
97.4
99
86
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
23.1
92.9
68
31
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
9.9
41.4
48
50
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
10.8
39.5
43
41
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.5
36.2
280
1294
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
4.0
33.8
101
269
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
6.2
32.7
57
96
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
31.7
28.2
37
12
BA1AE, ,
SPAT
6.9
26.4
41
61
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
26.4
26.3
36
14
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
25.6
25.4
35
14
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.1
25.3
113
390
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
29.8
24.1
32
11
T86
ICPC
Hypothyroidism/myxoedema
3.0
21.7
100
351
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
19.7
19.6
29
15
BAA30
NOMESCO Finland
Excision of thyroid isthmus
40.8
19.5
24
6
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.0
18.1
85
301
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
19.6
16.9
25
13
E03
ICD-10 Finland
Other hypothyroidism
2.4
16.3
115
501
EP1AE, ,
SPAT
3.8
16.1
49
132
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
24.8
16.0
22
9
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
33.8
15.8
20
6
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
4.9
14.5
32
67
E04.8
ICD-10 Finland
Other specified nontoxic goitre
14.0
13.3
22
16
WZC30
NOMESCO Finland
Teaching
1.8
12.9
231
1411
WX402
NOMESCO Finland
General anaesthesia
1.7
12.8
299
1967
2506
FHL
Thyroidectomy
14.8
11.8
19
13
T72
ICPC
Benign neoplasm thyroid
16.6
11.7
18
11
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
11.3
323
2226
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
11.3
309
2109
ZX114
NOMESCO Finland
Intramuscular
4.0
11.1
31
79
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
5.6
10.7
20
36
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
4.1
10.3
28
70
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
10.0
487
3749
SPAT1359
SPAT
Use of symptom diary
3.1
9.8
41
137
UKC02
NOMESCO Finland
Cystoscopy
1.7
9.5
177
1090
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
9.3
266
1824
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
8.5
439
3398
A02BC05
ATC
esomeprazole; systemic
1.4
8.4
520
4157
106
Kela drug reimbursment
Hypoparathyroidism
9.5
8.3
16
17
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.0
8.1
87
449
Z00.0
ICD-10 Finland
General medical examination
1.6
8.1
243
1681
A11CC03
ATC
alfacalcidol; systemic
3.0
8.1
34
114
BA1NN
NOMESCO Finland
I-131 dose capsel measurement
17.3
8.1
12
7
4CJ01, ,
NOMESCO Finland
17.3
8.1
12
7
E83.51
ICD-10 Finland
Hypocalcemia
6.1
7.9
20
33
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
8.5
7.8
16
19
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
15.1
7.7
12
8
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
3.4
7.7
27
81
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
2.8
7.7
38
140
S18
ICPC
Laceration/cut
1.4
7.6
589
4865
R01AD09
ATC
mometasone; nasal
1.4
7.6
569
4674
UJF32
NOMESCO Finland
Coloscopy
1.5
7.4
323
2411
R13
ICD-10 Finland
Dysphagia
1.9
7.3
98
546
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.3
1139
10631
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.7
7.2
22
60
BA3AT, ,
SPAT
20.1
7.1
10
5
Q18.8
ICD-10 Finland
Other specified congenital malformations of face and neck
20.1
7.1
10
5
RD211, ,
NOMESCO Finland
2.2
7.1
61
290
WX704
NOMESCO Finland
Intubation
1.8
6.9
103
595
J02AC01
ATC
fluconazole; systemic
1.4
6.8
522
4281
T71
ICPC
Malignant neoplasm thyroid
16.8
6.7
10
6
XKD00
NOMESCO Finland
Uroflowmetry
1.7
6.7
126
776
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
6.7
446
3574
8340/3-C73.9
ICD-O-3
Papillary carcinoma, follicular variant of thyroid gland
22.6
6.7
9
*
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.7
6.6
114
685
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
6.5
6.6
16
25
XX2RW, ,
NOMESCO Finland
3.3
6.6
24
74
J01FA09
ATC
clarithromycin; systemic
1.4
6.6
376
2936
WZC00
NOMESCO Finland
Treatment plan or consultation
1.4
6.5
448
3606
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.8
6.5
89
501
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
6.4
365
2844
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
8.2
6.3
13
16
A12AA04
ATC
calcium carbonate; oral
3.5
6.3
21
61
WZC15, ,
NOMESCO Finland
3.9
6.3
18
47
D44
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of endocrine glands
+∞
6.3
6
*
E06
ICD-10 Finland
Thyroiditis
+∞
6.3
6
*
D44.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Endocrine gland, unspecified
26.8
6.2
8
*
ZSB00
NOMESCO Finland
Procedure related to previous procedure classified in chapter B
26.8
6.2
8
*
A02BC01
ATC
omeprazole; systemic
1.4
6.2
325
2497
R07.0
ICD-10 Finland
Pain in throat
1.8
6.2
87
494
UDC00
NOMESCO Finland
Ear microscopy
1.8
6.2
91
524
S04
ICPC
Lump/swelling localized
1.6
6.1
142
925
E04
ICD-10 Finland
Other nontoxic goitre
8.6
6.1
12
14
D25.1
ICD-10 Finland
Intramural leiomyoma of uterus
1.8
6.0
82
461

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
130
65
22.15
172.25
7.1
6.7
168.60
268.08
ug/l
0.14
71
43
139
110
14.06
145.72
6.8
5.0
28.18
46.15
u/ml
0.76
51
37
216
349
7.24
132.02
1.4
1.2
—
—
—
0
0
224
781
3.26
50.44
4.9
3.5
4.46
4.48
pmol/l
0.11
210
688
1141
9297
3.11
37.01
8.4
4.7
15.56
14.78
pmol/l
18.41
1079
8564
819
6125
1.94
27.33
8.8
6.7
1.21
1.22
mmol/l
1.18
710
5311
1198
10689
2.91
20.54
9.9
5.9
1.74
1.91
mu/l
4.60
1129
9919
715
5499
1.68
18.00
6.7
6.0
1.21
1.21
mmol/l
1.17
677
5087
184
969
2.05
16.40
4.8
3.5
1.22
1.23
mmol/l
0.96
166
835
512
3735
1.62
14.95
4.9
4.0
7.40
7.40
ph
0.28
382
2691
257
1574
1.79
14.38
1.4
1.3
—
—
—
0
0
632
4907
1.57
13.80
2.6
2.2
—
—
—
0
0
176
997
1.89
12.56
2.9
3.5
71.12
81.02
ng/l
1.09
152
866
181
1072
1.80
11.15
1.6
1.4
—
—
—
0
0
561
4395
1.49
10.83
3.2
3.5
2.34
2.36
mmol/l
4.10
499
3991
366
2653
1.53
10.11
5.7
4.8
—
—
—
0
0
675
5581
1.44
9.37
2.9
2.7
—
—
estimate
—
0
0
686
5695
1.44
9.27
2.8
2.5
79.38
78.61
nmol/l
0.32
632
5143
185
1163
1.69
9.17
5.8
4.0
7.38
7.36
ph
1.34
151
827
717
6064
1.42
8.37
6.4
6.2
0.04
0.04
e9/l
0.02
630
5198
714
6053
1.41
8.10
6.4
6.1
0.56
0.57
e9/l
0.46
627
5188
725
6181
1.40
7.85
6.4
6.2
1.90
1.91
e9/l
0.07
653
5431
677
5709
1.39
7.80
6.5
6.3
27.89
27.82
%
0.05
642
5408
165
1064
1.63
7.37
4.4
4.3
0.07
0.12
%
0.51
47
269
144
901
1.67
7.23
1.3
1.2
99.12
138.42
u/ml
0.67
61
359
660
5590
1.37
7.15
6.6
6.3
2.78
2.80
%
0.09
623
5228
170
1115
1.61
7.09
4.4
4.2
0.74
0.98
%
0.78
51
323
658
5579
1.37
7.04
6.7
6.4
0.69
0.70
%
0.09
621
5205
660
5603
1.37
6.98
6.7
6.4
8.79
8.72
%
0.25
623
5245
162
1059
1.61
6.84
4.4
4.1
0.43
0.70
%
1.36
47
299
219
1537
1.51
6.75
3.1
3.2
4.00
4.61
e9/l
1.28
185
1327
724
6266
1.36
6.62
6.7
6.4
0.19
0.19
e9/l
0.06
652
5454
780
6833
1.36
6.57
4.9
4.7
6.58
6.65
mmol/l
0.45
749
6458
1200
11410
1.84
6.49
20.9
18.6
139.86
139.67
mmol/l
1.99
1189
11201
629
5340
1.35
6.46
15.2
14.1
1.22
1.23
inr
0.33
523
4417
657
5615
1.35
6.45
6.5
6.2
57.40
57.32
%
0.06
633
5355
1200
11428
1.81
6.20
21.1
18.8
3.94
3.96
mmol/l
2.19
1188
11200
475
3909
1.34
5.82
2.4
2.4
—
—
—
0
0
1174
11144
1.65
5.73
18.2
15.9
21.40
22.86
mg/l
0.82
983
9186
770
6817
1.33
5.57
10.2
9.7
4.01
4.05
e9/l
0.18
683
5943
142
945
1.57
5.56
5.0
3.9
—
—
—
0
0
157
1070
1.53
5.53
4.9
4.5
0.00
0.45
%
0.78
37
244
978
9023
1.36
5.00
9.9
8.2
78.72
78.46
u/l
0.06
945
8556
60
326
1.88
4.93
4.5
5.9
1.23
1.29
mmol/l
0.33
53
295
479
4022
1.31
4.88
5.7
6.0
—
—
—
0
0
45
225
2.04
4.70
3.8
3.3
—
—
—
0
0
62
347
1.83
4.66
8.5
9.4
—
—
—
0
0
423
3511
1.31
4.65
5.0
4.2
0.00
0.00
estimate
1.47
188
1243
363
2959
1.32
4.53
2.5
2.3
—
—
—
0
0
26
105
2.51
4.48
1.2
1.1
108.92
108.79
pmol/l
0.00
26
105
643
5661
1.27
4.37
3.3
3.1
122.65
106.76
ug/l
0.97
595
5270
451
3803
1.29
4.33
2.9
2.5
52.27
61.16
u/l
3.62
411
3526
1219
11787
1.73
4.22
24.5
21.0
76.07
73.92
umol/l
1.43
1210
11667
14
41
3.44
4.19
2.9
1.9
28.64
31.00
%
0.22
14
41
97
633
1.58
4.17
2.0
1.8
—
—
—
0
0
403
3372
1.28
4.06
4.4
3.5
1.93
0.05
estimate
0.69
172
1050
1188
11438
1.54
3.90
17.2
14.4
—
—
—
0
0
1237
12032
1.86
3.89
28.6
24.6
253.45
255.68
e9/l
0.64
1214
11825
1237
12035
1.85
3.84
28.4
24.5
91.00
91.23
fl
1.18
1228
11928
1237
12037
1.84
3.81
28.5
24.6
4.45
4.43
e12/l
1.19
1210
11792
1237
12037
1.84
3.81
28.9
25.0
40.11
39.89
%
0.88
1225
11925
1237
12037
1.84
3.81
28.4
24.5
30.18
30.29
pg
1.51
1228
11928
1237
12038
1.84
3.79
28.5
24.7
6.55
6.72
e9/l
1.19
1211
11789
255
2025
1.32
3.77
3.0
3.0
0.83
0.82
mmol/l
0.75
239
1916
1237
12041
1.83
3.74
28.7
24.8
133.73
133.22
g/l
0.70
1228
11931
311
2540
1.30
3.74
1.8
1.7
31801204.11
33602715.72
pmol/l
0.02
261
2107
609
5392
1.25
3.72
4.7
4.7
35.97
35.79
g/l
0.37
566
5068
701
6314
1.24
3.64
7.5
6.4
11.09
10.95
umol/l
0.09
672
6033
40
213
1.91
3.57
3.4
3.5
3.86
4.24
e9/l
0.48
40
213
221
1735
1.33
3.53
1.3
1.2
—
—
—
0
0
40
214
1.90
3.52
2.1
3.8
2.35
2.82
mmol/l
0.72
27
153
514
4503
1.24
3.36
4.2
3.8
28.13
54.14
ng/l
0.86
356
3162
537
4729
1.23
3.33
4.8
4.1
0.17
0.07
estimate
0.31
171
1081
26
121
2.17
3.33
3.0
2.6
—
—
—
0
0
44
248
1.80
3.31
2.0
2.0
4.26
4.94
mmol/24h
0.82
38
220
20
83
2.43
3.31
1.9
1.6
109.35
94.89
ng/l
0.21
20
83
59
364
1.65
3.24
1.9
2.0
2.21
19.56
iu/l
0.58
21
151
583
5194
1.23
3.20
14.6
11.3
0.00
0.00
e9/l
0.27
490
4241
101
709
1.46
3.14
3.0
3.5
7.42
7.42
ph
0.90
84
591
839
7768
1.23
3.13
5.4
5.0
68.60
2201.54
e6/l
—
5
108
1207
11720
1.53
3.11
14.4
12.4
23.96
24.68
u/l
1.12
1174
11410
421
3635
1.24
3.10
3.1
3.1
945.84
1108.55
ng/l
0.50
360
3092
293
2437
1.26
2.99
1.4
1.3
26.54
31.71
iu/ml
0.33
102
774
11
31
3.57
2.99
1.5
1.2
14.14
6.24
pmol/l
—
5
8
444
3871
1.23
2.95
3.6
3.4
54.31
40.86
mg/l
0.56
253
2354
179
1401
1.32
2.92
1.3
1.3
—
—
—
0
0
8
17
4.73
2.92
1.5
1.5
—
—
—
0
0
463
4060
1.22
2.90
3.6
3.3
6.75
7.07
mmol/l
0.97
383
3441
690
6292
1.21
2.88
4.8
4.2
6.66
5.82
estimate
0.04
204
1354
113
828
1.40
2.81
1.3
1.3
157.82
172.47
u/ml
0.10
106
762
217
1756
1.28
2.77
1.5
1.4
586.67
534.94
titre
0.14
51
399
696
6367
1.20
2.76
4.7
4.1
0.02
0.25
estimate
0.48
197
1274
683
6239
1.20
2.75
4.8
4.1
0.00
0.00
estimate
0.50
199
1310
125
943
1.36
2.62
3.8
2.9
10.82
10.69
g/l
0.12
116
864
40
237
1.71
2.60
4.4
3.7
151.66
1563.19
u/ml
0.73
32
224
70
476
1.50
2.59
2.2
1.9
0.91
1.96
ug/l
0.88
62
424
365
3157
1.22
2.57
4.0
4.1
—
—
—
0
0
1128
10880
1.31
2.53
5.6
5.3
5.88
5.91
mmol/l
0.31
1035
9990
350
3023
1.22
2.49
2.5
2.6
320.07
331.09
umol/l
1.35
303
2672
445
3936
1.20
2.47
4.5
4.0
10.46
7.86
mg/mmol
0.40
244
2332
25
130
1.94
2.46
1.2
1.2
—
—
—
0
0
153
1201
1.31
2.46
2.8
2.0
354.97
382.26
nmol/l
0.92
136
1120
1146
11097
1.31
2.34
5.4
5.2
4.67
4.71
mmol/l
0.65
1059
10346
288
2456
1.22
2.31
1.6
1.5
2.27
2.40
g/l
0.79
191
1492
223
1858
1.24
2.23
2.6
2.4
2.37
2.34
g/l
0.47
205
1713
85
620
1.40
2.22
1.2
1.2
—
—
—
0
0
237
1989
1.24
2.22
2.7
2.4
13.55
12.86
umol/l
0.78
222
1844
32
188
1.72
2.18
1.5
1.3
0.65
10.13
nmol/l
0.50
32
179
24
129
1.88
2.17
1.7
1.6
23.50
25.15
ng/l
0.17
24
129
1160
11272
1.31
2.13
6.3
6.0
2.70
2.73
mmol/l
0.60
1071
10474
24
130
1.86
2.13
2.2
2.4
—
—
—
0
0
267
2279
1.22
2.12
1.4
1.3
6.38
13.69
u/ml
1.79
114
847
1139
11044
1.29
2.11
5.4
5.1
1.53
1.52
mmol/l
0.04
1051
10232
79
576
1.40
2.08
2.6
2.2
0.00
0.01
estimate
0.50
31
176
144
1149
1.29
2.07
2.3
2.2
0.22
0.21
g/l
0.87
129
1083
42
270
1.57
2.05
4.2
2.8
7.96
8.01
kpa
0.07
42
264
37
232
1.61
2.00
4.6
2.7
90.33
89.70
%
0.29
37
224
27
157
1.74
1.93
1.5
1.3
—
—
nmol/l
—
0
0
323
2831
1.19
1.93
1.3
1.3
0.97
1.50
u/ml
0.96
98
758
76
559
1.38
1.92
1.3
1.2
—
—
—
0
0
294
2557
1.19
1.91
2.6
2.8
2.44
2.46
mmol/l
1.21
267
2306
203
1706
1.23
1.88
2.6
2.4
22.70
22.26
%
0.17
186
1588
416
3734
1.17
1.86
2.0
2.1
157.54
210.05
u/l
0.97
395
3548
41
270
1.54
1.83
3.7
3.4
56.07
59.18
%
0.75
41
270
97
749
1.32
1.81
2.0
1.8
1.21
1.37
g/l
0.41
90
684
24
138
1.75
1.80
5.4
2.2
32.37
31.96
pg
0.25
24
138
7
23
3.05
1.80
1.3
1.1
—
—
—
0
0
1091
10569
1.22
1.76
4.5
4.3
1.26
1.27
mmol/l
0.09
990
9688
544
5010
1.15
1.69
2.0
1.9
1.30
1.35
mmol/l
0.44
450
4234
185
1564
1.21
1.63
5.4
4.8
1.03
1.03
mmol/l
0.03
173
1442
90
1143
0.77
1.60
2.1
2.3
53.61
37.18
u/l
0.44
79
954
441
4016
1.15
1.59
3.5
3.3
—
—
—
0
0
49
347
1.43
1.57
1.9
2.1
9027.54
5207.76
u/l
0.26
19
143
47
331
1.44
1.56
1.0
1.1
—
—
—
0
0
15
78
1.93
1.54
3.0
2.0
74.07
72.78
%
0.14
15
73
351
3150
1.16
1.54
2.5
2.2
2.88
2.85
mg/l
0.08
296
2706
6
140
0.43
1.52
1.7
1.6
—
—
—
0
0
123
1009
1.24
1.46
4.1
2.6
68.28
71.69
e9/l
0.43
97
730
47
336
1.41
1.45
2.8
2.6
1.44
1.50
mg/l
0.20
42
303
79
614
1.31
1.45
1.4
1.4
28.30
30.18
iu/l
0.21
69
534
390
3547
1.14
1.41
1.7
1.7
20.81
20.85
nmol/l
0.02
333
2967
53
391
1.37
1.38
3.2
2.6
—
—
—
0
0
37
256
1.46
1.37
1.3
1.2
14.99
11.99
u/l
0.53
32
206
182
1564
1.19
1.37
2.6
2.3
125.67
120.96
ug/g
0.08
141
1251
150
1268
1.21
1.35
1.5
1.5
—
—
—
0
0
0
40
0.00
1.32
0.0
2.1
—
—
—
0
0
25
160
1.57
1.32
2.8
2.5
—
—
—
0
0
297
2663
1.15
1.31
2.8
2.6
4.73
6.80
e6/l
1.82
266
2435
150
1275
1.20
1.28
4.6
4.1
12.84
17.99
ug/l
0.28
116
1038
68
529
1.30
1.27
1.4
1.2
0.26
1.05
u/ml
—
9
32
255
2270
1.15
1.25
3.1
2.8
509.00
512.97
mosm/kgh2o
0.11
219
1997
1092
10649
1.17
1.25
6.8
6.4
39.41
39.21
mmol/mol
0.34
1016
9969
6
25
2.41
1.24
1.3
2.2
—
—
—
0
0
50
661
0.75
1.23
4.0
2.9
24.88
24.28
mmol/l
0.96
50
650
15
85
1.77
1.23
3.0
1.9
44.11
39.60
%
0.41
15
85
65
508
1.29
1.18
2.1
3.5
—
—
—
0
0
19
117
1.63
1.18
1.8
2.1
14.04
5.87
umol/l
0.35
11
79
170
1473
1.18
1.18
1.3
1.4
—
—
—
0
0
22
141
1.57
1.17
5.2
2.3
1.72
1.10
g/24h
0.51
16
87
19
118
1.62
1.15
2.4
1.3
7.45
6.90
g/l
0.17
13
91
19
118
1.62
1.15
2.4
1.3
2.96
2.83
g/l
0.13
13
89
19
118
1.62
1.15
2.4
1.3
0.52
0.35
g/l
0.78
13
90
21
134
1.58
1.14
1.5
1.1
—
—
—
0
0
14
80
1.76
1.13
1.7
1.7
13.00
18.98
nmol/l
2.48
14
75
5
114
0.44
1.12
1.0
1.1
—
—
—
0
0
19
119
1.61
1.12
2.4
1.3
—
—
—
0
0
192
1689
1.16
1.11
1.6
1.6
—
—
—
0
0
12
207
0.58
1.10
2.2
1.9
—
—
—
0
0
22
144
1.54
1.09
1.3
1.2
—
—
—
0
0
21
137
1.54
1.06
1.7
1.6
45.71
59.53
%
0.69
14
89
33
451
0.72
1.04
1.8
1.5
0.23
0.32
mg/l
0.78
11
195
15
90
1.67
1.04
1.1
1.3
—
—
—
0
0
114
968
1.20
1.02
3.2
2.8
6.08
6.08
ph
0.00
69
648
5
107
0.47
1.01
1.0
1.1
—
—
—
0
0
792
7611
1.11
1.00
3.4
3.3
48.30
46.32
u/l
0.23
745
7147
12
68
1.77
1.00
1.3
3.0
17.40
16.65
%
0.27
12
68
152
1326
1.17
0.99
3.0
2.6
1.72
1.85
%
0.64
134
1181
27
189
1.44
0.99
1.3
1.3
—
—
—
0
0
9
49
1.84
0.98
1.0
1.1
—
—
—
0
0
5
23
2.18
0.98
9.6
2.7
—
—
—
0
0
895
9218
0.90
0.92
22.5
21.0
331.49
331.32
g/l
0.23
887
9174
6
28
2.15
0.91
1.2
1.3
—
0.32
—
0
5
212
1910
1.13
0.89
1.8
1.8
—
—
—
0
0
459
4315
1.10
0.89
3.3
3.2
—
—
—
0
0
134
1172
1.16
0.87
2.3
2.1
0.00
0.02
estimate
0.78
38
224
217
1965
1.13
0.85
6.3
5.7
2.63
2.54
ug/l
0.07
200
1758
31
231
1.35
0.83
1.2
1.4
—
—
—
0
0
6
32
1.88
0.82
1.2
1.2
—
12.00
%
—
0
7
187
1683
1.13
0.81
2.2
1.9
—
—
—
0
0
16
236
0.67
0.81
2.6
3.1
32.88
34.64
umol/l
0.18
16
209
18
122
1.48
0.80
1.2
1.1
—
—
—
0
0
0
26
0.00
0.78
0.0
1.7
—
—
—
0
0
13
82
1.59
0.78
1.9
2.3
503.38
611.78
ml
—
8
55
21
292
0.71
0.78
2.5
2.2
69.06
60.20
%
1.20
21
279
24
174
1.39
0.77
1.1
1.1
79.94
98.22
iu/ml
—
10
36
6
34
1.77
0.76
2.7
2.0
0.00
0.00
estimate
—
6
34
22
302
0.72
0.76
1.0
1.2
—
—
—
0
0
25
183
1.37
0.76
1.4
1.4
0.27
0.35
nmol/l
0.49
20
137
65
776
0.83
0.76
12.0
8.6
1.31
1.32
%
0.03
65
769
10
59
1.70
0.76
1.3
1.2
595.10
449.04
u/l
—
10
54
404
3805
1.09
0.74
3.3
3.3
87.94
65.86
e6/l
0.18
316
2893
17
116
1.47
0.74
1.4
1.5
1.73
3.76
ug/l
1.11
12
99
62
741
0.83
0.73
12.4
9.0
0.68
0.65
%
0.24
62
736
15
100
1.51
0.73
3.3
2.0
1178.07
1187.74
e6/l
0.02
15
89
5
25
2.00
0.72
1.6
1.3
—
—
—
0
0
6
110
0.54
0.72
1.2
1.1
—
—
—
0
0
18
126
1.43
0.70
1.3
1.8
89.96
89.66
%
0.06
18
126
17
238
0.71
0.67
3.1
4.0
20.85
24.84
mg/l
—
8
162
129
1151
1.13
0.67
3.6
3.1
7.38
7.38
ph
0.39
77
640
16
111
1.45
0.66
1.1
1.2
—
—
—
0
0
125
1115
1.13
0.65
3.7
3.1
2.40
1.87
mmol/l
1.16
112
965
15
212
0.70
0.63
1.7
1.5
—
—
—
0
0
109
966
1.14
0.63
1.6
1.7
—
—
—
0
0
74
637
1.17
0.63
2.4
2.4
—
—
—
0
0
49
406
1.22
0.63
4.7
4.0
34.67
71.54
mg/l
1.35
42
351
44
361
1.23
0.62
4.4
3.8
1.28
3.36
ratio
1.27
32
204
8
50
1.60
0.61
1.3
1.6
—
76.13
%
—
0
8
290
2716
1.09
0.61
2.0
1.7
0.97
1.17
mg/l
0.81
229
2108
15
210
0.71
0.61
1.6
1.6
—
—
—
0
0
49
408
1.21
0.60
4.7
4.0
33.07
51.51
mg/l
1.03
42
354
0
20
0.00
0.60
0.0
2.1
—
2.30
—
0
20
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.4
—
62.57
—
0
23
40
328
1.23
0.57
1.3
1.2
—
—
—
0
0
952
9330
1.08
0.57
21.3
19.8
13.64
13.66
%
0.13
940
9208
12
171
0.70
0.55
1.2
1.1
—
—
—
0
0
94
835
1.14
0.54
2.5
2.5
29.84
24.29
au/ml
—
7
83
43
358
1.21
0.54
1.2
1.3
189.42
229.51
miu/ml
0.37
22
164
64
553
1.17
0.54
4.8
4.3
36.91
36.91
°c
0.00
64
548
97
865
1.13
0.53
2.7
2.6
—
—
—
0
0
129
1171
1.11
0.53
3.9
3.3
0.80
0.77
ug/l
0.12
88
763
15
204
0.73
0.53
1.5
1.5
—
—
—
0
0
9
136
0.66
0.51
1.7
1.4
—
—
—
0
0
61
528
1.16
0.51
2.8
2.3
12.20
12.58
nmol/l
0.14
54
480
25
197
1.27
0.51
2.4
1.6
0.84
0.81
g/l
0.04
19
159
26
206
1.27
0.51
1.5
1.5
—
—
—
0
0
456
4375
1.07
0.50
4.0
3.9
72.72
96.06
e6/l
0.55
333
3035
9
65
1.39
0.50
1.1
1.1
1.20
1.06
ratio
—
9
54
330
3133
1.07
0.50
3.1
3.1
—
0.00
estimate
—
0
9
240
2252
1.08
0.50
4.0
3.9
229.95
361.77
ng/l
0.50
174
1730
97
872
1.12
0.48
1.3
1.3
—
—
—
0
0
26
208
1.26
0.48
2.8
1.3
—
10.40
—
0
5
12
85
1.42
0.47
1.2
1.2
—
—
—
0
0
5
81
0.62
0.46
1.2
1.1
—
—
—
0
0
5
84
0.59
0.45
1.0
1.1
—
—
—
0
0
7
50
1.40
0.45
1.0
1.5
2.57
1.99
umol/l
—
7
43
38
448
0.84
0.44
2.5
2.4
9.33
10.39
g/l
0.73
31
408
43
367
1.18
0.44
2.2
1.6
297.54
302.45
mu/l
0.05
43
337
83
923
0.89
0.44
1.3
1.4
—
—
—
0
0
45
386
1.17
0.44
2.3
3.4
4211.90
279.97
mg/l
0.52
20
155
190
2029
0.93
0.44
3.0
2.8
1.01
1.14
e6/l
0.25
106
1043
344
3288
1.06
0.43
3.4
3.1
0.39
0.45
e6/l
0.16
257
2402
8
57
1.41
0.42
1.0
1.1
1745.13
1762.18
miu/ml
—
8
57
113
1036
1.10
0.41
2.7
2.9
68.19
66.86
g/l
1.17
104
953
0
15
0.00
0.41
0.0
1.1
—
0.03
—
0
15
0
15
0.00
0.41
0.0
1.4
—
1.38
—
0
8
0
15
0.00
0.41
0.0
1.0
—
74.67
—
0
15
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
1.95
—
0
9
0
17
0.00
0.40
0.0
1.0
—
5.32
—
0
10
0
17
0.00
0.40
0.0
1.1
—
6.48
—
0
17
518
5019
1.05
0.40
4.0
3.6
6.16
6.25
ph
1.00
289
2810
5
34
1.47
0.40
1.2
1.3
2.00
2.90
%
—
5
29
65
579
1.13
0.39
1.0
1.1
—
122.00
—
0
13
10
71
1.41
0.39
1.3
1.3
100.90
76.61
umol/l
—
10
71
14
106
1.32
0.39
1.1
1.1
—
—
—
0
0
187
1758
1.07
0.39
2.1
1.9
28.82
29.26
s
0.56
178
1708
94
858
1.10
0.38
1.3
1.4
—
—
—
0
0
8
114
0.70
0.37
1.3
1.4
—
—
—
0
0
45
393
1.15
0.37
1.4
1.4
261.96
291.40
ug/g
0.40
23
232
69
764
0.90
0.36
11.4
8.9
92.76
93.89
%
0.37
69
757
21
172
1.22
0.34
1.1
1.1
1.36
0.68
u/ml
0.29
13
81
25
209
1.20
0.34
1.4
1.3
—
—
—
0
0
21
253
0.83
0.33
1.3
1.4
—
—
—
0
0
6
46
1.31
0.33
1.2
2.1
42.15
40.92
g/l
—
6
46
61
550
1.11
0.32
2.1
1.8
5.42
8.22
iu/ml
0.43
20
122
18
146
1.24
0.32
1.1
1.4
6.42
7.52
mmol/l
1.53
13
123
143
1343
1.07
0.32
7.8
7.3
7.41
7.42
ph
0.11
79
766
22
183
1.21
0.32
1.1
1.2
—
—
—
0
0
143
1345
1.07
0.31
7.7
7.2
5.13
5.08
kpa
0.31
138
1302
143
1345
1.07
0.31
7.7
7.2
12.19
12.28
kpa
0.07
138
1303
25
212
1.18
0.30
1.8
1.8
46.84
44.51
nmol/l
0.16
25
202
551
5380
1.04
0.30
2.2
2.1
102.49
97.00
pmol/l
1.76
286
2732
102
949
1.08
0.30
2.4
2.4
4.59
7.32
ug/l
1.21
80
838
19
157
1.21
0.29
5.0
2.3
1.02
0.90
%
0.39
14
100
22
185
1.19
0.29
1.3
1.3
121.33
165.26
au/ml
—
6
51
8
109
0.73
0.29
1.9
1.6
—
—
—
0
0
24
204
1.18
0.28
1.5
1.2
284.60
248.52
u/ml
—
10
113
45
501
0.89
0.28
2.2
1.8
1.42
1.52
g/l
0.32
40
440
145
1372
1.06
0.27
2.0
1.7
—
—
—
0
0
21
246
0.85
0.26
1.4
1.3
65.21
59.18
mmol/l
0.30
14
200
213
2043
1.05
0.26
1.8
1.7
1130.86
1192.94
nmol/l
0.47
165
1531
64
588
1.09
0.26
1.7
2.0
—
—
—
0
0
49
444
1.11
0.25
1.1
1.1
—
—
—
0
0
9
72
1.25
0.25
3.0
2.0
—
—
—
0
0
21
179
1.18
0.25
1.0
1.2
—
—
—
0
0
9
76
1.19
0.24
1.0
1.0
—
—
—
0
0
130
1371
0.94
0.24
2.1
2.6
8.42
7.29
umol/l
0.19
105
1207
177
1849
0.95
0.24
3.1
3.0
2.33
3.15
e6/l
0.72
89
861
38
341
1.12
0.24
1.1
1.2
—
1108.46
—
0
13
126
1195
1.06
0.23
7.9
7.5
95.69
95.61
%
0.04
121
1162
105
990
1.07
0.23
1.2
1.2
—
—
—
0
0
5
38
1.32
0.23
1.2
1.3
58.80
59.25
%
—
5
32
55
598
0.92
0.23
3.8
3.5
1.02
1.02
ratio
0.21
48
545
27
238
1.14
0.22
1.2
1.2
—
—
—
0
0
5
41
1.22
0.22
2.0
1.7
65.60
78.51
nmol/24h
—
5
41
0
11
0.00
0.21
0.0
1.4
—
51.82
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
0.07
—
0
5
0
11
0.00
0.21
0.0
4.5
—
0.18
—
0
11
0
11
0.00
0.21
0.0
1.2
—
43.50
—
0
6
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
3.0
—
—
—
0
0
17
145
1.17
0.20
1.2
1.1
4.32
2.98
u/ml
—
9
55
0
14
0.00
0.20
0.0
1.0
—
9.24
—
0
14
9
115
0.78
0.20
2.6
2.6
—
—
—
0
0
13
154
0.84
0.19
1.6
1.2
—
—
—
0
0
6
53
1.13
0.18
2.0
2.4
39.85
171.00
ug/l
—
6
46
7
59
1.19
0.18
4.0
1.7
—
—
—
0
0
18
157
1.15
0.17
1.2
1.1
0.93
2.50
u/ml
1.27
11
72
42
388
1.09
0.17
1.4
1.2
30.52
2.76
u/ml
—
6
38
8
69
1.16
0.16
1.6
1.3
—
—
—
0
0
9
79
1.14
0.15
1.1
1.1
351.78
225.21
mg/l
—
9
68
370
3632
1.03
0.15
5.7
6.2
—
—
—
0
0
138
1333
1.04
0.14
7.9
7.2
1.11
1.09
mmol/l
0.03
123
1112
13
112
1.16
0.14
1.7
1.7
—
—
—
0
0
32
347
0.92
0.14
1.2
1.2
—
—
—
0
0
28
256
1.10
0.14
1.3
1.5
—
—
—
0
0
58
548
1.06
0.14
1.1
1.1
—
—
—
0
0
14
158
0.88
0.12
1.9
2.8
—
—
—
0
0
23
210
1.10
0.12
1.1
1.1
39.40
17.21
au/ml
—
5
59
46
435
1.06
0.11
1.3
1.2
—
—
—
0
0
30
322
0.93
0.11
2.0
3.3
2.22
2.02
index
0.07
18
161
20
219
0.91
0.11
1.1
1.2
21.17
21.01
u/l
0.01
15
188
11
96
1.15
0.10
1.8
1.6
13.20
33.29
%
—
5
58
5
44
1.14
0.10
1.6
3.9
—
—
—
0
0
5
46
1.09
0.09
1.0
1.2
134.40
185.13
iu/ml
—
5
46
5
47
1.06
0.09
2.2
1.1
—
—
—
0
0
5
47
1.06
0.09
2.2
1.1
—
—
—
0
0
5
47
1.06
0.09
2.2
1.1
—
—
—
0
0
13
145
0.90
0.09
4.0
6.1
14.25
12.51
mg/l
0.64
13
138
42
399
1.05
0.09
1.3
1.3
—
—
—
0
0
6
55
1.09
0.09
6.7
2.5
—
—
—
0
0
30
318
0.94
0.08
1.5
1.6
12625.62
12075.51
e6/l
0.03
21
227
28
297
0.94
0.08
1.3
1.4
—
—
—
0
0
16
174
0.92
0.07
1.1
1.1
0.34
1.54
u/ml
—
9
72
17
184
0.92
0.07
1.2
1.2
10.14
4.53
u/ml
—
7
70
30
284
1.06
0.07
2.1
2.0
133.12
126.98
g/l
0.78
25
226
7
82
0.85
0.07
1.3
1.6
5.51
7.84
ug/l
—
7
70
7
84
0.83
0.07
1.1
1.0
—
—
—
0
0
11
122
0.90
0.07
1.0
1.1
—
—
—
0
0
28
265
1.06
0.07
2.5
2.3
32.72
103.24
ug/min
1.65
15
153
38
396
0.96
0.06
1.4
1.2
0.88
0.89
g/l
0.07
38
396
40
416
0.96
0.06
1.4
1.6
1205.66
1028.95
mu/l
0.39
33
335
87
850
1.03
0.06
1.7
1.8
3.58
3.52
mmol/l
0.18
59
596
61
628
0.97
0.06
3.0
2.4
1.17
1.21
%
0.17
61
623
33
316
1.05
0.05
1.3
1.4
—
—
—
0
0
18
169
1.07
0.05
1.0
1.1
1.53
2.11
eliau/ml
—
8
67
17
181
0.94
0.05
1.1
1.0
5.35
3.87
u/ml
—
9
90
34
353
0.96
0.04
1.2
1.1
0.71
0.67
ratio
—
7
45
20
189
1.06
0.04
1.2
1.0
—
—
—
0
0
27
282
0.96
0.04
2.1
1.7
—
—
—
0
0
115
1132
1.02
0.04
2.1
2.0
3.43
3.37
ratio
0.25
84
880
96
977
0.98
0.04
9.0
7.8
—
—
—
0
0
326
3237
1.01
0.04
1.6
1.4
—
—
—
0
0
89
875
1.02
0.04
4.1
3.1
121.85
194.90
ng/l
3.30
82
804
22
230
0.96
0.03
1.2
1.7
1.08
0.88
nmol/l
0.52
17
189
19
181
1.05
0.03
1.2
1.1
—
—
—
0
0
50
489
1.02
0.03
1.6
1.6
7.53
12.48
u/ml
—
9
97
14
132
1.06
0.02
1.4
1.5
—
—
—
0
0
399
3976
1.01
0.02
3.3
3.1
31.27
31.47
u/l
0.04
373
3767
31
318
0.97
0.02
1.3
1.4
—
—
—
0
0
14
133
1.05
0.01
1.1
1.0
0.56
0.23
u/ml
—
5
40
109
1082
1.01
0.01
1.7
1.4
—
—
—
0
0
14
136
1.03
0.00
1.1
1.1
—
—
—
0
0
20
196
1.02
0.00
1.0
1.1
—
—
—
0
0
32
324
0.99
0.00
1.2
1.4
516.47
521.06
mg/l
0.03
32
310
12
118
1.02
0.00
1.3
1.2
—
—
—
0
0
13
128
1.02
0.00
3.0
2.3
—
—
—
0
0
13
128
1.02
0.00
1.9
2.2
—
—
—
0
0
27
272
0.99
0.00
4.8
4.6
—
—
—
0
0
14
141
0.99
0.00
1.8
1.5
36.21
33.11
g/l
0.37
14
127
16
161
0.99
0.00
1.1
1.4
—
—
—
0
0
16
161
0.99
0.00
1.1
1.4
—
—
—
0
0
16
161
0.99
0.00
1.1
1.4
—
—
—
0
0
16
161
0.99
0.00
1.1
1.4
—
—
—
0
0
38
381
1.00
0.00
1.4
1.1
1.59
1.59
g/l
0.02
38
381
11
113
0.97
0.00
1.7
1.5
—
—
—
0
0
15
153
0.98
0.00
1.3
1.2
—
—
—
0
0
276
2757
1.00
0.00
4.8
4.4
1.02
1.57
kg/l
0.50
190
1832
22
217
1.01
0.00
1.1
1.1
0.97
1.75
u/ml
0.52
14
116
25
247
1.01
0.00
1.8
1.8
—
—
—
0
0
32
315
1.02
0.00
1.3
1.4
—
—
—
0
0
32
315
1.02
0.00
1.3
1.4
—
—
—
0
0
20
195
1.03
0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
90.83
—
0
6
5
51
0.98
-0.00
1.6
3.5
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.6
10.29
11.97
umol/l
—
8
72
338
3380
1.00
-0.00
3.3
3.1
0.00
0.03
—
5
79
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
8.0
—
10.38
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
-0.00
1.0
1.3
31.83
29.91
umol/l
—
6
58
0
5
0.00
-0.00
0.0
1.2
—
30.86
—
0
5
6
67
0.90
-0.00
1.0
3.1
1.00
0.78
index
—
6
67
0
5
0.00
-0.00
0.0
2.0
—
283.80
—
0
5
0
7
0.00
-0.00
0.0
4.1
—
12.66
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.0
—
37.50
—
0
8
5
54
0.93
-0.00
1.2
1.2
5.40
9.59
mm/h
—
5
54
0
5
0.00
-0.00
0.0
1.4
—
2.60
—
0
5
7
76
0.92
-0.00
1.4
2.8
8.71
9.16
mmol/l
—
7
76
0
5
0.00
-0.00
0.0
1.0
—
0.06
—
0
5
11
110
1.00
-0.00
1.5
1.4
20533.33
104277.98
e6/l
—
6
51
0
6
0.00
-0.00
0.0
1.5
—
383.17
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
12
120
1.00
-0.00
1.2
3.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
65
0.92
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
3.74
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
-0.00
4.4
2.2
—
22.34
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_THYROID and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_THYROID 0.943 [0.83, 1.06] 0.343
Birth year 0.993 [0.98, 1.0] 0.136

During the follow-up period (1.1.1998 — 31.12.2019), 416 out of 3924 females with CD2_BENIGN_THYROID died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_THYROID 1.195 [1.01, 1.42] 0.042
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 240 out of 1134 males with CD2_BENIGN_THYROID died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_THYROID.

N-year risk Females Males
1 0.091% 0.186%
5 0.58% 1.233%
10 1.361% 3.105%
15 2.586% 5.841%
20 4.419% 10.295%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_THYROID – Benign neoplasm of thyroid gland

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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