No definition available.
Inflammation of lacrimal passages (acute and unspecified)
DOID EFO Endpoint Browser PheWeb
H7_LACRIMINFLAMACU
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
777 |
4. Check minimum number of eventsNone |
777 |
5. Include endpointsNone |
777 |
6. Filter based on genotype QC (FinnGen only) |
689 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H04
- Name in latin
- Inflammatio viarum lacrimalium acuta sive non specificata
Similar endpoints
↥List of similar endpoints to
Inflammation of lacrimal passages (acute and unspecified)
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5708 | 4089 | 1592 |
| Only index persons | 4945 | 3555 | 1390 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.12 | 0.04 |
| Only index persons | 0.11 | 0.13 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 58.12 | 62.11 | 48.00 |
| Only index persons | 56.05 | 59.83 | 46.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 689 | 511 | 178 |
| Unadjusted period prevalence (%) | 0.16 | 0.18 | 0.08 |
| Median age at first event (years) | 58.35 | 57.61 | 60.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 716
- Matched controls
- 7160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
828.9
307.7
297
6
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
14111.1
307.7
687
12
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
1361.9
214.0
198
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
+∞
134.7
125
*
H04.4
ICD-10 Finland
Chronic inflammation of lacrimal passages
+∞
108.1
101
*
H04.10
ICD-10 Finland
Dry eye syndrome
7.6
91.2
146
233
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.6
88.7
419
1692
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
897.2
83.3
80
*
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
784.8
73.5
71
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
65.6
62
*
H04.0
ICD-10 Finland
Dacryoadenitis
217.9
59.0
60
*
H02.3
ICD-10 Finland
Blepharochalasis
22.2
56.2
42
20
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.8
42.0
104
244
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.7
39.7
101
242
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
37.6
396
2241
H01.0
ICD-10 Finland
Blepharitis
5.2
36.9
81
171
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.5
34.2
91
225
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.2
30.4
88
232
F29
ICPC
Eye symptom/complaint other
3.5
29.6
117
382
F03
ICPC
Eye discharge
4.1
29.5
88
237
H04.2
ICD-10 Finland
Epiphora
59.4
29.4
34
6
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.8
29.3
179
753
J01DB01
ATC
cefalexin; oral
3.6
26.5
640
5034
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
+∞
25.1
24
*
S01AX11
ATC
[U] ofloxacin
5.1
24.7
54
113
UDM02
NOMESCO Finland
Sinoscopy
6.6
23.8
39
62
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.2
23.3
105
369
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
226.6
21.7
22
*
H00.03
ICD-10 Finland
Preseptal cellulite in the eyelid
44.8
21.5
26
6
S01ED01
ATC
timolol; ophthalmic
4.9
20.4
46
99
36803
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Dacryocystitis acuta, phlegmonosa
+∞
19.9
19
*
CCA30
NOMESCO Finland
Incision of lacrimal sac
+∞
18.8
18
*
H57.1
ICD-10 Finland
Ocular pain
4.4
18.6
48
115
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
+∞
17.8
17
*
CCD40
NOMESCO Finland
Percutaneous dacryocystorhinostomy
+∞
17.8
17
*
H02.4
ICD-10 Finland
Ptosis of eyelid
26.3
17.0
23
9
R01AD09
ATC
mometasone; nasal
1.9
16.8
354
2394
S01EE04
ATC
travoprost; ophthalmic
7.2
16.6
25
36
S01ED51
ATC
timolol, combinations; ophthalmic
2.9
15.4
78
292
S01XA18
ATC
ciclosporin; ophthalmic
57.9
14.8
17
*
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
14.6
166
897
H00.1
ICD-10 Finland
Chalazion
5.2
14.4
30
60
J01FF01
ATC
clindamycin; systemic
2.0
14.4
213
1265
H10
ICD-10 Finland
Conjunctivitis
2.8
14.0
72
271
CCC50
NOMESCO Finland
Dacryocystectomy
+∞
13.6
13
*
R06AE07
ATC
cetirizine; oral
1.8
13.6
334
2325
114
Kela drug reimbursment
Glaucoma
2.6
13.4
85
357
H02AB06
ATC
prednisolone; systemic
1.8
13.0
349
2481
H02.1
ICD-10 Finland
Ectropion of eyelid
71.2
12.6
14
*
A02BC02
ATC
pantoprazole; systemic
1.8
12.5
494
3921
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
12.4
198
1197
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
4.2
12.2
33
82
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
12.0
380
2810
XCK00
NOMESCO Finland
Perimetry
3.0
11.9
55
195
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
11.7
277
1883
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.5
11.7
40
118
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
11.5
11
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
11.4
144
801
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.3
11.4
94
444
R51.80
ICD-10 Finland
Headache
2.0
11.3
132
714
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.4
11.3
86
392
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.6
11.3
38
111
H16.0
ICD-10 Finland
Corneal ulcer
3.2
11.0
44
143
S01AA01
ATC
chloramphenicol; ophthalmic
3.1
10.9
47
160
L04AX03
ATC
methotrexate; systemic
2.3
10.8
83
379
S01AD03
ATC
aciclovir; ophthalmic
4.0
10.8
31
81
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
10.7
363
2706
H02AB04
ATC
methylprednisolone; systemic
2.1
10.6
114
597
L01BA01
ATC
methotrexate; systemic
3.5
10.5
37
111
3753A
ICD-9 Finland
Disorders of lachrymal system, Acute and unspecified inflammation of lachrymal passages
+∞
10.4
10
*
CC1CB
NOMESCO Finland
Dacryocystography
+∞
10.4
10
*
F73
ICPC
Eye infection/inflammation other
4.3
10.4
27
65
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
16.3
10.4
16
10
S01EX03, ,
ATC
4.4
10.4
26
61
XCH00
NOMESCO Finland
Eye pressure measurement
3.1
10.3
44
149
H00.00
ICD-10 Finland
Hordeolum
3.3
10.3
40
128
H10.5
ICD-10 Finland
Blepharoconjunctivitis
4.8
10.3
23
49
S01EA05
ATC
brimonidine; ophthalmic
4.1
10.1
28
71
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
10.1
305
2196
H16.9
ICD-10 Finland
Keratitis, unspecified
5.2
9.9
20
39
S29
ICPC
Skin symptom/complaint other
1.9
9.9
154
917
M79.6
ICD-10 Finland
Pain in limb
1.7
9.7
325
2394
ZXA05
NOMESCO Finland
Left side
1.8
9.6
177
1107
J01DA01
ATC
[U] cefalexin
1.7
9.6
440
3506
WX002
NOMESCO Finland
Sedation and analgesia
1.9
9.5
135
778
A02BC05
ATC
esomeprazole; systemic
1.7
9.5
290
2083
J01AA02
ATC
doxycycline; systemic
1.8
9.5
547
4625
H04
ICD-10 Finland
Disorders of lacrimal system
+∞
9.4
9
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.0
9.4
119
661
L02.0
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of face
4.8
9.3
21
45
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.5
9.3
32
95
S01GX08
ATC
ketotifen; ophthalmic
3.0
9.2
42
148
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
9.2
331
2473
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.7
9.2
29
81
S01EE01
ATC
latanoprost; ophthalmic
2.5
9.1
58
243
J01MA02
ATC
ciprofloxacin; systemic
1.6
9.0
268
1907
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
9.0
90
458
J01FA10
ATC
azithromycin; systemic
1.6
9.0
408
3220
H40.0
ICD-10 Finland
Glaucoma suspect
2.3
8.8
65
292
R01AD12
ATC
fluticasone furoate; nasal
1.7
8.8
218
1479
M54.5
ICD-10 Finland
Low back pain
1.6
8.6
264
1888
S01EC01
ATC
acetazolamide; systemic
3.9
8.6
25
66
H40.9
ICD-10 Finland
Glaucoma, unspecified
4.3
8.5
22
53
ZXA00
NOMESCO Finland
Right side
1.7
8.5
185
1210
CCD30
NOMESCO Finland
Reconstruction of lacrimal canaliculus
91.1
8.4
9
*
H04.9
ICD-10 Finland
Disorder of lacrimal system, unspecified
91.1
8.4
9
*
H02.8
ICD-10 Finland
Other specified disorders of eyelid
91.1
8.4
9
*
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
+∞
8.3
8
*
N02AX02
ATC
tramadol; systemic, rectal
1.6
8.2
296
2196
L04AA06
ATC
mycophenolic acid; systemic
6.9
8.1
19
28
H00.01
ICD-10 Finland
Abscess of the eyelid
33.8
8.1
10
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
8.1
96
520
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.4
8.0
55
239
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.7
8.0
42
160
N02BE01
ATC
paracetamol; systemic, rectal
2.0
8.0
635
5707
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
7.4
8.0
18
25
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.2
7.9
69
333
P01BA02
ATC
hydroxychloroquine; oral
2.2
7.9
67
320
A02BC01
ATC
omeprazole; systemic
1.7
7.9
195
1317
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
3.9
7.8
23
61
WX402
NOMESCO Finland
General anaesthesia
1.7
7.8
154
977
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
7.8
199
1354
F01
ICPC
Eye pain
3.3
7.7
28
86
H16.8
ICD-10 Finland
Other keratitis
45.5
7.7
9
*
J01CA04
ATC
amoxicillin; systemic
1.7
7.6
569
4972
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.4
7.6
50
214
S18
ICPC
Laceration/cut
1.6
7.5
317
2423
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
3.0
7.5
32
109
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.6
7.5
43
172
S01EC03
ATC
dorzolamide; ophthalmic
6.1
7.4
19
32
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.1
7.4
74
377
L30.0
ICD-10 Finland
Nummular dermatitis
3.2
7.4
29
94
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
+∞
7.3
7
*
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
+∞
7.3
7
*
3755A
ICD-9 Finland
Disorders of lachrymal system, Stenosis and insufficiency of lachrymal passages
+∞
7.3
7
*
E0000UV, ,
ATC
1.6
7.3
288
2166
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
7.3
241
1741
R05
ICPC
Cough
1.6
7.3
182
1229
S01EE05
ATC
tafluprost; ophthalmic
3.0
7.3
32
111
R42
ICD-10 Finland
Dizziness and giddiness
1.7
7.2
169
1121
R60.0
ICD-10 Finland
Localized oedema
1.9
7.2
94
525
H20.1
ICD-10 Finland
Chronic iridocyclitis
7.4
7.2
16
22
R50.9
ICD-10 Finland
Fever, unspecified
1.8
7.2
109
639
B00.5
ICD-10 Finland
Herpesviral ocular disease
30.3
7.2
9
*
J02AC01
ATC
fluconazole; systemic
1.5
7.2
281
2109
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
12.2
7.1
12
10
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.2
7.1
27
86
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.2
7.0
58
274
D23.1
ICD-10 Finland
Benign neoplasm: Skin of eyelid, including canthus
3.1
7.0
29
97
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
7.0
487
4129
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.7
6.8
21
58
K07.60
ICD-10 Finland
Snapping jaw
2.4
6.8
45
193
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.0
6.7
69
355
R29
ICPC
Respiratory symptom/complaint other
2.2
6.7
55
259
R07.0
ICD-10 Finland
Pain in throat
2.3
6.6
50
228
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
6.5
169
1149
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
2.7
6.5
34
130
127
Kela drug reimbursment
Transplant complication
7.5
6.4
14
19
L13
ICPC
Hip symptom/complaint
1.7
6.4
142
926
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.5
6.4
41
173
XQ802
NOMESCO Finland
Epicutan test
2.7
6.4
33
125
J20
ICD-10 Finland
Acute bronchitis
1.9
6.4
77
419
H26.4
ICD-10 Finland
After-cataract
1.9
6.4
77
419
R21
ICPC
Throat symptom/complaint
1.7
6.4
144
944
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
6.4
278
2121
ZXA10
NOMESCO Finland
Bilateral
1.7
6.4
126
798
R52.9
ICD-10 Finland
Pain, unspecified
1.9
6.3
75
406
M31.3
ICD-10 Finland
Wegener granulomatosis
11.1
6.3
11
10
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
2.0
6.3
68
356
XCK10
NOMESCO Finland
Photography of fundus of eye
2.0
6.3
65
335
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
18.2
6.3
9
5
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
18.2
6.3
9
5
M05BX04
ATC
denosumab; parenteral
2.1
6.3
57
280
36802
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Obstructio, stenosis viarum lacrimalium
+∞
6.3
6
*
H04.6
ICD-10 Finland
Other changes in lacrimal passages
+∞
6.3
6
*
CBN99
NOMESCO Finland
Other operation on eyelid for malposition
+∞
6.3
6
*
H03.1*B02.3
ICD-10 Finland
Zoster blepharitis
+∞
6.3
6
*
R03AC03
ATC
terbutaline; inhalant
1.8
6.3
96
565
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
3.4
6.2
22
67
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.6
6.2
189
1334
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.3
6.1
47
215
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.8
6.1
93
545
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.4
6.1
42
183
WX199
NOMESCO Finland
Other local analgesia
2.8
6.1
29
105
R60.9
ICD-10 Finland
Oedema, unspecified
2.3
6.1
47
216
L05
ICPC
Flank/axilla symptom/complaint
2.2
6.1
50
236
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
6.0
152
1024
H15.1
ICD-10 Finland
Episcleritis
6.1
6.0
15
25
J01FA06
ATC
roxithromycin; oral
1.5
6.0
266
2030
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.6
6.0
155
1050
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
438
3514
1.63
9.06
13.5
9.3
4.01
4.13
e9/l
0.70
387
3076
418
3352
1.59
8.35
5.1
3.9
0.00
0.02
estimate
1.32
92
694
439
3568
1.60
8.23
6.3
4.6
6.52
6.63
mmol/l
0.59
419
3365
354
2745
1.57
8.07
7.3
4.6
35.77
35.58
g/l
0.26
334
2584
410
3294
1.57
7.96
4.9
3.9
0.00
0.00
estimate
0.50
87
716
411
3319
1.56
7.68
5.0
3.9
0.00
6.57
estimate
1.07
93
730
172
1131
1.69
7.66
1.4
1.3
4.74
11.76
u/ml
1.74
67
449
270
1996
1.57
7.42
4.5
3.2
122.39
51.10
e6/l
0.39
212
1513
537
4650
1.62
7.10
10.9
7.7
79.37
79.41
u/l
0.01
515
4403
387
3116
1.53
7.10
9.6
6.7
1.22
1.21
mmol/l
0.72
340
2684
199
1394
1.59
6.79
2.2
1.7
1.40
1.25
mg/l
0.20
164
1102
352
2798
1.51
6.73
8.6
5.9
1.22
1.21
mmol/l
0.32
332
2580
80
435
1.94
6.66
1.9
1.6
—
—
—
0
0
482
4129
1.51
6.15
6.1
4.7
20.90
2500.31
e6/l
—
10
65
231
1707
1.52
6.11
4.3
3.1
0.22
0.37
e6/l
1.38
173
1242
358
2898
1.47
6.01
3.1
2.5
79.55
78.25
nmol/l
0.40
340
2617
117
742
1.69
5.86
2.2
1.8
—
—
—
0
0
173
1216
1.56
5.70
1.4
1.3
28.46
30.33
iu/ml
0.08
46
384
252
1930
1.47
5.49
3.7
2.5
66.64
61.79
u/l
0.24
237
1787
645
5968
1.81
5.43
23.1
15.1
20.11
23.53
mg/l
2.40
580
4921
52
263
2.05
5.32
1.9
1.8
7.45
8.88
iu/ml
0.18
15
68
549
4896
1.52
5.25
5.2
4.5
14.90
14.82
pmol/l
0.35
517
4502
149
1034
1.56
5.15
3.9
2.8
0.81
1.16
e6/l
0.85
86
519
189
1383
1.50
5.11
3.7
2.6
6.26
6.50
e6/l
0.08
174
1275
515
4545
1.47
5.08
6.6
4.3
13.35
12.42
mm/h
0.84
493
4233
109
706
1.64
5.02
2.3
1.8
—
—
—
0
0
200
1487
1.48
4.98
4.0
2.6
327.29
332.78
umol/l
0.32
182
1312
15
33
4.62
4.89
4.0
2.2
—
—
—
0
0
99
630
1.66
4.88
3.7
1.9
332.86
382.18
nmol/l
2.04
93
584
146
1021
1.54
4.86
2.3
1.9
—
—
—
0
0
25
96
2.66
4.77
14.8
5.4
337.40
200.00
iu/ml
—
5
11
160
1150
1.50
4.68
4.9
3.8
488.15
299.26
ng/l
0.40
116
880
665
6257
1.88
4.64
16.1
11.5
26.16
24.78
u/l
0.93
641
6084
309
2520
1.40
4.56
4.7
3.9
6.53
0.04
estimate
0.49
77
600
649
6069
1.74
4.54
25.4
17.8
3.95
3.96
mmol/l
0.27
632
5940
72
430
1.75
4.48
1.6
1.2
167.61
250.55
u/ml
0.51
67
395
48
253
1.96
4.42
2.5
2.4
37.43
40.60
u/l
0.47
42
228
134
944
1.52
4.29
4.0
3.0
2.64
2.88
e6/l
0.09
68
431
668
6316
1.86
4.26
27.9
19.6
75.45
74.70
umol/l
0.20
660
6235
142
1019
1.49
4.15
5.0
3.1
0.82
0.82
mmol/l
0.05
134
962
37
183
2.08
4.06
2.3
2.8
—
—
—
0
0
189
1440
1.42
4.04
4.9
4.1
1.02
1.02
kg/l
0.06
133
968
343
2890
1.36
3.97
3.1
2.7
—
—
estimate
—
0
0
645
6065
1.64
3.85
25.2
17.7
139.57
139.62
mmol/l
0.18
631
5947
81
521
1.63
3.84
3.3
2.4
0.31
0.43
e6/l
0.42
76
494
329
2771
1.35
3.74
20.9
13.7
1.24
1.23
inr
0.15
288
2304
20
78
2.61
3.74
1.1
1.1
—
—
—
0
0
235
1882
1.37
3.70
2.4
2.1
137.93
223.84
u/l
1.60
224
1793
195
1515
1.39
3.69
2.7
2.2
—
—
—
0
0
154
1149
1.43
3.66
1.6
1.6
—
—
—
0
0
600
5572
1.47
3.59
6.8
6.2
38.77
39.12
mmol/mol
0.52
563
5220
612
5718
1.48
3.43
5.5
5.0
5.83
5.90
mmol/l
0.77
566
5242
424
3738
1.33
3.40
3.4
3.1
—
—
—
0
0
18
70
2.61
3.40
2.0
1.2
—
—
—
0
0
281
2341
1.33
3.34
4.3
3.8
25.69
78.72
ng/l
1.19
184
1654
32
163
2.01
3.29
1.4
1.6
7626.38
17974.10
e6/l
1.22
26
113
32
163
2.01
3.29
1.2
1.4
—
—
—
0
0
207
1651
1.36
3.28
2.7
2.3
2.73
2.94
mg/l
0.88
193
1406
677
6488
1.80
3.23
33.6
23.3
256.55
255.51
e9/l
0.14
662
6373
170
1318
1.38
3.21
1.8
1.7
470.32
16047583.42
pmol/l
1.07
145
1103
677
6490
1.79
3.20
33.5
23.2
91.69
90.99
fl
3.39
667
6427
677
6491
1.79
3.18
34.3
23.6
39.69
39.96
%
0.59
667
6423
677
6491
1.79
3.18
33.6
23.2
4.42
4.44
e12/l
0.70
659
6362
139
1045
1.41
3.15
2.7
2.5
12.68
12.71
umol/l
0.02
134
965
677
6495
1.78
3.12
33.9
23.4
133.30
133.40
g/l
0.07
668
6429
34
181
1.92
3.10
1.7
1.2
7.82
1.92
u/ml
—
6
21
17
69
2.50
2.98
2.8
2.2
16.50
24.01
mg/l
—
10
29
61
393
1.60
2.91
2.3
2.4
19.71
22.14
au/ml
—
7
45
371
3253
1.29
2.90
8.3
6.2
10.71
11.21
umol/l
0.48
361
3101
163
1275
1.36
2.90
3.4
2.8
2.45
2.46
mmol/l
0.48
145
1146
76
516
1.53
2.90
4.6
3.5
1.23
1.23
mmol/l
0.16
69
434
77
525
1.52
2.88
4.2
2.7
66.33
67.22
g/l
0.52
72
483
34
187
1.86
2.84
2.1
1.6
0.22
0.23
g/l
0.48
34
180
110
808
1.43
2.83
8.2
6.1
103.97
104.05
mmol/l
0.06
110
808
262
2201
1.30
2.83
4.3
3.4
2.36
2.36
mmol/l
0.16
235
1978
11
33
3.37
2.82
1.9
3.8
105.09
101.30
%
0.10
11
33
33
182
1.85
2.74
1.6
1.2
3.67
7.64
u/ml
—
7
37
603
5680
1.39
2.65
6.6
5.5
1.84
1.90
mu/l
0.76
569
5266
163
1293
1.34
2.63
1.7
1.4
2.26
2.39
g/l
0.55
113
795
26
135
1.96
2.58
1.4
1.4
—
—
—
0
0
34
194
1.79
2.55
2.0
1.6
1.15
1.19
g/l
0.42
34
187
6
11
5.49
2.55
1.0
1.0
—
—
—
0
0
219
1820
1.29
2.52
4.1
3.4
0.34
0.01
estimate
0.52
79
583
604
5705
1.38
2.49
19.8
14.7
81.03
80.73
ml/min/173m2
0.13
565
5278
348
3067
1.26
2.47
3.9
3.0
113.65
112.17
ug/l
0.04
330
2855
12
46
2.64
2.37
2.9
2.7
572.17
805.13
mg
0.42
12
46
222
1865
1.28
2.32
5.4
4.1
0.00
0.01
estimate
0.99
82
673
68
475
1.48
2.30
4.3
2.7
64.86
65.73
ml/min/173m2
0.06
29
215
312
2732
1.25
2.29
2.3
2.1
96.46
96.38
pmol/l
0.01
164
1393
28
156
1.83
2.29
1.5
1.3
10.28
11.34
u/l
0.20
22
130
135
1063
1.33
2.28
1.9
1.8
1193.03
1215.54
nmol/l
0.11
109
791
84
613
1.42
2.26
7.2
3.3
1.79
1.92
mmol/l
0.15
73
517
244
2079
1.26
2.26
4.3
3.1
29.43
30.68
u/l
0.48
225
1962
29
164
1.80
2.26
1.3
1.2
—
—
—
0
0
108
825
1.36
2.23
8.5
5.0
1.04
1.04
mmol/l
0.04
101
747
22
114
1.96
2.22
1.3
1.1
0.70
1.93
u/ml
0.57
12
55
57
387
1.51
2.21
4.6
3.2
4.41
4.57
pmol/l
0.61
46
341
5
9
5.58
2.21
1.6
1.0
78.60
107.67
%
—
5
9
34
205
1.69
2.15
2.7
2.0
0.56
1.24
g/l
0.75
29
179
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
29
168
1.76
2.10
4.2
2.5
0.39
0.40
iu/ml
0.09
17
95
88
658
1.38
2.07
7.6
7.1
0.59
1.18
mmol/l
0.64
71
541
10
37
2.73
2.07
1.1
1.2
—
—
—
0
0
538
5039
1.27
2.07
27.0
18.8
13.74
13.65
%
0.81
531
4981
19
96
2.01
2.07
2.3
1.5
151.57
158.98
au/ml
—
7
29
6
15
4.02
2.04
2.3
3.5
0.59
0.62
mmol/l
—
6
15
111
865
1.34
2.02
3.8
4.5
23.58
22.00
%
0.43
49
415
52
355
1.50
1.99
1.5
1.7
—
—
—
0
0
28
164
1.74
1.97
1.3
1.2
—
—
—
0
0
6
16
3.77
1.94
1.0
1.0
—
—
—
0
0
21
113
1.88
1.93
1.4
1.4
—
—
—
0
0
66
479
1.42
1.86
2.3
2.4
7.51
6.32
ug/l
0.25
56
420
20
108
1.88
1.83
1.3
1.1
32.68
14.98
au/ml
—
5
31
14
66
2.14
1.83
1.2
1.1
0.01
0.50
u/ml
—
7
18
26
153
1.73
1.82
2.4
3.5
0.80
1.26
index
0.46
15
86
30
184
1.66
1.81
1.7
1.3
316.20
305.79
ug/g
0.11
20
107
32
200
1.63
1.80
3.2
3.5
33.62
76.85
mg/l
0.79
26
170
44
297
1.51
1.79
1.3
1.4
—
—
—
0
0
533
5017
1.24
1.79
30.0
19.5
331.48
331.50
g/l
0.01
527
4987
102
800
1.32
1.79
2.9
2.4
107.02
117.89
ug/g
0.26
83
630
30
185
1.65
1.78
1.4
1.3
—
—
—
0
0
32
201
1.62
1.77
3.2
3.5
22.88
61.39
mg/l
1.25
26
171
438
4050
1.21
1.71
4.2
3.2
51.69
44.96
u/l
0.49
413
3811
84
645
1.34
1.70
2.9
3.0
0.78
0.77
ug/l
0.02
52
390
17
90
1.91
1.66
1.2
1.1
0.17
1.06
u/ml
—
10
41
7
25
2.82
1.65
1.3
1.4
—
—
—
0
0
46
320
1.47
1.64
1.3
1.3
25.16
26.63
iu/l
0.10
40
277
212
1835
1.22
1.64
3.7
3.1
1398.38
1374.39
ng/l
0.03
186
1554
27
166
1.65
1.63
2.1
1.5
—
—
—
0
0
27
166
1.65
1.63
2.1
1.5
—
—
—
0
0
134
1104
1.26
1.62
4.4
5.1
5.34
2.45
ug/l
0.61
122
989
176
1497
1.23
1.60
1.4
1.3
1.00
1.58
u/ml
0.69
61
387
15
77
1.97
1.60
1.3
1.4
—
—
—
0
0
31
200
1.57
1.56
1.2
1.2
—
—
—
0
0
24
146
1.67
1.52
1.3
1.2
—
1.99
—
0
12
617
5940
1.28
1.49
6.0
5.6
2.72
2.74
mmol/l
0.15
571
5518
19
109
1.76
1.48
1.3
1.3
—
—
—
0
0
19
109
1.76
1.48
1.3
1.3
—
—
—
0
0
44
311
1.44
1.47
3.7
3.4
1.02
1.02
ratio
0.04
39
288
7
28
2.51
1.45
1.0
1.8
—
1.11
—
0
5
11
52
2.13
1.45
1.8
1.3
0.46
0.35
u/ml
—
5
27
6
22
2.74
1.43
1.2
1.0
—
—
—
0
0
29
189
1.56
1.42
1.2
1.3
—
—
—
0
0
28
181
1.57
1.42
3.0
3.2
2.08
4.38
ratio
0.56
18
108
45
323
1.42
1.40
1.5
1.5
—
—
—
0
0
27
174
1.57
1.39
1.4
1.2
—
—
—
0
0
9
41
2.21
1.37
1.2
1.2
—
—
—
0
0
86
686
1.29
1.36
7.8
6.9
—
—
—
0
0
208
1827
1.20
1.36
2.0
1.7
20.73
20.39
nmol/l
0.12
182
1539
20
120
1.69
1.35
3.0
2.7
10.01
8.26
pmol/l
0.19
20
120
21
128
1.66
1.34
1.2
1.5
—
—
—
0
0
19
113
1.70
1.33
1.1
1.4
—
—
—
0
0
0
41
0.00
1.31
0.0
1.0
—
624.19
—
0
26
0
41
0.00
1.31
0.0
1.0
—
38.97
—
0
24
9
43
2.11
1.30
1.1
1.6
—
594.29
—
0
7
8
34
2.37
1.29
1.9
1.4
—
—
—
0
0
8
35
2.30
1.27
1.0
1.2
—
—
—
0
0
14
77
1.83
1.26
2.6
1.4
—
—
—
0
0
71
559
1.30
1.25
3.2
2.3
35.23
33.78
u/l
0.14
61
468
5
20
2.51
1.15
1.0
1.5
—
—
—
0
0
7
31
2.27
1.10
1.7
2.8
510.86
883.13
u/ml
—
7
31
36
262
1.39
1.08
2.1
1.8
1.38
1.26
ug/l
0.07
29
230
11
59
1.88
1.08
1.0
1.2
—
—
—
0
0
5
22
2.28
1.03
5.0
6.0
—
—
—
0
0
13
75
1.75
1.03
1.3
1.3
—
—
—
0
0
77
630
1.25
1.03
3.4
3.3
—
—
—
0
0
64
513
1.27
1.01
4.8
3.5
111.55
81.72
ng/l
1.49
56
446
25
172
1.47
1.01
1.6
1.9
0.00
0.00
g/l
-0.00
20
151
600
5814
1.20
1.01
5.3
4.9
1.50
1.51
mmol/l
0.07
556
5394
9
48
1.89
1.00
1.1
1.2
—
—
—
0
0
13
76
1.72
0.99
1.3
1.3
—
—
—
0
0
13
76
1.72
0.99
1.3
1.3
—
—
—
0
0
9
49
1.85
0.99
2.8
1.3
—
—
—
0
0
18
116
1.57
0.97
1.6
1.2
354.62
213.36
u/ml
—
9
58
35
259
1.37
0.97
2.1
1.8
1.26
1.43
g/l
0.64
29
227
602
5841
1.19
0.96
5.5
5.0
4.68
4.70
mmol/l
0.13
561
5450
6
27
2.23
0.93
1.0
1.1
—
—
—
0
0
227
2066
1.14
0.92
3.6
3.3
7.18
7.25
mmol/l
0.07
192
1754
6
29
2.08
0.89
1.7
4.2
1.33
0.86
index
—
6
29
19
128
1.50
0.86
1.7
1.3
—
—
—
0
0
85
721
1.20
0.83
4.3
2.7
6.72
8.00
umol/l
0.40
69
618
12
73
1.65
0.82
1.3
1.3
—
—
—
0
0
12
73
1.65
0.82
1.3
1.3
—
—
—
0
0
6
32
1.88
0.82
1.0
1.1
1105.17
1662.75
miu/ml
—
6
32
8
48
1.67
0.79
1.0
1.0
—
—
—
0
0
8
48
1.67
0.79
1.0
1.2
—
—
—
0
0
8
48
1.67
0.79
1.0
1.2
—
—
—
0
0
12
74
1.63
0.78
1.3
1.3
—
—
—
0
0
45
359
1.27
0.78
4.6
3.7
1.65
1.84
mmol/l
0.19
34
269
12
75
1.61
0.75
1.2
1.1
—
—
—
0
0
7
38
1.85
0.73
2.7
3.5
74.57
144.95
nmol/l
—
7
38
22
159
1.40
0.73
2.2
1.5
—
—
—
0
0
12
77
1.57
0.69
1.0
1.0
—
—
—
0
0
10
61
1.65
0.68
1.4
1.3
101340.00
46138.54
e6/l
—
5
35
5
29
1.73
0.64
2.2
1.5
—
—
—
0
0
12
79
1.53
0.63
2.7
1.4
—
—
—
0
0
8
50
1.61
0.61
1.0
1.2
—
—
—
0
0
8
50
1.61
0.61
1.0
1.2
—
—
—
0
0
28
218
1.30
0.61
1.1
1.1
0.91
0.90
g/l
0.09
28
218
8
52
1.54
0.59
1.0
1.2
—
—
—
0
0
8
53
1.52
0.58
2.0
2.5
—
—
—
0
0
20
149
1.35
0.58
1.8
2.0
132.69
128.56
g/l
0.33
13
122
266
2510
1.10
0.55
2.1
1.9
1.35
1.34
mmol/l
0.05
225
2123
9
63
1.43
0.52
2.0
1.8
—
—
—
0
0
6
40
1.50
0.51
1.2
1.3
—
—
—
0
0
124
1130
1.12
0.51
1.5
1.5
—
—
—
0
0
22
171
1.30
0.50
1.3
1.6
84.74
61.34
ug/l
0.82
16
143
210
1970
1.09
0.49
4.6
4.1
8.00
9.57
mg/mmol
0.22
124
1206
21
163
1.30
0.48
1.3
1.5
—
—
—
0
0
13
93
1.41
0.48
1.0
1.1
3.27
1.75
eliau/ml
—
6
35
11
76
1.45
0.48
2.2
1.9
33.18
32.18
pg
0.37
11
76
21
165
1.28
0.45
1.4
1.5
0.92
0.96
ratio
0.28
13
105
21
165
1.28
0.45
1.4
1.5
1.54
1.21
ratio
0.31
13
105
21
165
1.28
0.45
1.4
1.5
1.09
1.20
ratio
0.24
14
105
52
451
1.16
0.45
1.6
1.5
—
—
—
0
0
29
238
1.23
0.44
2.4
1.9
—
—
—
0
0
10
140
0.71
0.43
3.2
1.2
4.13
3.63
mmol/l
—
10
133
566
5550
1.09
0.43
4.6
4.2
1.30
1.27
mmol/l
0.54
522
5111
41
351
1.18
0.42
1.7
2.0
—
—
—
0
0
5
33
1.52
0.41
1.2
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.9
—
8.36
—
0
8
28
232
1.22
0.40
1.8
2.1
2265.18
6227.86
u/l
0.99
11
88
26
214
1.22
0.40
1.8
1.5
—
—
—
0
0
5
35
1.43
0.39
1.2
1.4
—
—
—
0
0
5
35
1.43
0.39
4.6
1.5
—
—
—
0
0
5
35
1.43
0.39
4.6
1.5
—
—
—
0
0
9
66
1.37
0.38
2.2
2.3
12.94
13.06
%
—
9
66
5
36
1.39
0.38
1.0
1.7
65.00
106.26
ng/l
—
5
36
5
37
1.35
0.37
1.4
1.2
2.89
2.04
mmol/l
—
5
37
6
42
1.43
0.35
1.0
1.3
—
—
—
0
0
6
42
1.43
0.35
1.0
1.3
—
—
—
0
0
10
73
1.38
0.34
1.0
1.2
—
—
—
0
0
11
82
1.35
0.34
1.5
1.3
—
0.60
nmol/l
—
0
6
6
45
1.34
0.34
1.5
1.0
448.33
219.82
mg/l
—
6
38
47
417
1.14
0.33
1.9
2.1
—
—
—
0
0
12
154
0.78
0.32
2.9
1.3
514.83
500.66
mg/l
0.03
12
148
26
220
1.19
0.32
2.3
1.7
—
—
—
0
0
19
156
1.22
0.31
2.0
1.6
—
—
—
0
0
71
651
1.10
0.29
1.8
2.1
—
—
—
0
0
25
213
1.18
0.29
1.1
1.1
1.57
1.59
g/l
0.12
25
213
7
57
1.23
0.29
2.3
1.8
—
—
—
0
0
8
64
1.25
0.27
1.1
1.1
105.88
93.60
%
—
8
57
9
120
0.75
0.27
1.7
1.8
—
—
—
0
0
13
104
1.25
0.26
2.6
1.6
—
—
—
0
0
24
209
1.15
0.23
1.3
1.4
290.08
246.37
miu/ml
0.18
12
103
5
39
1.28
0.23
1.2
1.2
—
—
—
0
0
5
39
1.28
0.23
1.2
1.4
—
—
—
0
0
5
40
1.25
0.22
1.2
1.3
—
—
—
0
0
14
116
1.21
0.22
4.1
3.8
998.19
2433.92
u/ml
0.29
14
109
0
10
0.00
0.21
0.0
1.4
—
54.20
—
0
10
75
703
1.07
0.21
1.9
2.2
—
—
—
0
0
5
43
1.16
0.21
1.2
1.8
5.94
7.96
mmol/l
—
5
43
17
145
1.18
0.20
2.3
1.8
42.65
42.84
nmol/l
0.01
17
140
33
297
1.12
0.20
1.1
1.1
—
—
—
0
0
27
241
1.13
0.19
1.3
1.5
—
—
—
0
0
11
91
1.21
0.17
1.1
1.4
—
—
—
0
0
18
204
0.88
0.16
1.3
1.6
—
—
—
0
0
11
94
1.17
0.13
1.5
1.2
5.83
4.14
u/ml
—
6
37
50
472
1.06
0.13
1.1
1.2
226.12
135.84
u/ml
0.54
17
173
12
104
1.16
0.12
1.3
1.3
—
—
—
0
0
75
720
1.05
0.11
5.4
4.9
33.41
32.65
%
0.28
49
468
20
219
0.91
0.11
2.2
1.8
—
—
—
0
0
5
45
1.11
0.10
1.2
1.9
—
—
—
0
0
60
625
0.96
0.09
2.0
1.9
3.43
3.42
ratio
0.03
47
498
5
48
1.04
0.09
1.4
1.4
—
—
—
0
0
6
55
1.09
0.09
1.0
1.3
—
—
—
0
0
18
165
1.09
0.09
1.3
1.2
—
—
—
0
0
10
88
1.14
0.08
1.4
1.7
—
—
—
0
0
7
65
1.08
0.08
2.9
3.5
—
—
—
0
0
6
73
0.82
0.07
1.5
1.6
—
—
—
0
0
8
75
1.07
0.07
2.1
2.5
105.38
105.73
mmol/l
—
8
75
8
75
1.07
0.07
2.1
2.5
1.19
1.19
mmol/l
—
8
75
71
690
1.03
0.06
1.9
1.7
1.42
1.44
%
0.07
64
613
9
102
0.88
0.06
1.1
1.6
102.02
50.98
ug/l
—
9
102
27
256
1.06
0.06
1.4
1.5
0.15
0.34
mg/l
—
7
111
13
136
0.96
0.00
1.3
1.7
—
—
—
0
0
18
174
1.04
0.00
3.7
1.8
2.79
4.56
iu/l
—
7
66
13
135
0.96
0.00
2.1
2.2
248.80
100.65
ug/min
—
6
74
11
108
1.02
0.00
2.6
2.0
213.18
223.84
pmol/l
0.14
11
99
47
473
0.99
0.00
1.8
1.7
3.47
3.48
mmol/l
0.02
33
348
65
647
1.01
0.00
4.8
4.2
12.47
25.95
ug/l
0.45
54
533
23
231
1.00
0.00
1.2
1.5
—
—
—
0
0
30
299
1.00
0.00
1.4
1.6
975.30
978.47
mu/l
0.01
23
246
7
74
0.95
0.00
1.1
1.4
7.44
7.48
mmol/l
—
7
62
5
51
0.98
0.00
1.0
1.1
1.55
1.37
nmol/l
—
5
42
0
8
0.00
0.00
0.0
8.0
—
5.88
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
13.73
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
9.86
—
0
7
0
6
0.00
-0.00
0.0
3.7
—
58.62
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
90
1.00
-0.00
1.1
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
6.10
—
0
7
0
9
0.00
-0.00
0.0
2.1
—
0.56
—
0
9
0
7
0.00
-0.00
0.0
7.1
—
9.37
—
0
7
5
56
0.89
-0.00
1.0
1.3
152.60
493.13
u/l
—
5
56
7
75
0.93
-0.00
1.9
3.1
13.00
75.90
u/ml
—
7
75
Mortality – FinRegistry
↥Association
Association between endpoint H7_LACRIMINFLAMACU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LACRIMINFLAMACU | 1.139 [1.0, 1.3] | 0.053 |
| Birth year | 0.995 [0.99, 1.0] | 0.211 |
During the follow-up period (1.1.1998 — 31.12.2019), 749 out of 3226 females with H7_LACRIMINFLAMACU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LACRIMINFLAMACU | 1.276 [1.02, 1.59] | 0.031 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1257 males with H7_LACRIMINFLAMACU died.
Mortality risk
Mortality risk for people of age
years, who have H7_LACRIMINFLAMACU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.103% | 0.272% |
| 5 | 0.591% | 1.552% |
| 10 | 1.593% | 3.938% |
| 15 | 2.97% | 7.327% |
| 20 | 5.483% | 12.006% |
Relationships between endpoints
↥Index endpoint: H7_LACRIMINFLAMACU – Inflammation of lacrimal passages (acute and unspecified)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data