Benign neoplasm: Vulva

CD2_BENIGN_VAGINA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D28.0&
  • Hospital discharge: ICD-8 2212
  • Cause of death: ICD-10 D28.0&
  • Cause of death: ICD-8 2212

2 out of 7 registries used, show all original rules.

838

4. Check minimum number of events

None

838

5. Include endpoints

None

838

6. Filter based on genotype QC (FinnGen only)

760

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D28
Name in latin
Neoplasma benignum vulvae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5127 5127 -
Only index persons 4729 4729 -
Unadjusted period prevalence (%)
Whole population 0.15 0.15 -
Only index persons 0.17 0.17 -
Median age at first event (years)
Whole population - 42.27 -
Only index persons - 41.49 -

-FinnGen-

Key figures

All Female Male
Number of individuals 760 760 -
Unadjusted period prevalence (%) 0.27 0.27 -
Median age at first event (years) 42.15 42.15 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
784
Matched controls
7840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
84.3
307.7
206
33
D28.0
ICD-10 Finland
Benign neoplasm: Vulva
4334.0
307.7
543
*
22120
ICD-8 Finland
Benign neoplasm of other female genital organs, Vulva
+∞
141.0
131
*
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
27.8
75.7
52
20
22121, ,
ICD-8 Finland
+∞
57.0
54
*
22122, ,
ICD-8 Finland
+∞
54.8
52
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
6.5
51.5
90
154
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.4
14.9
110
495
N75.0
ICD-10 Finland
Cyst of Bartholin gland
5.7
12.5
23
41
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.1
12.0
134
712
LFW96
NOMESCO Finland
Other operation on vulva or perineum
66.0
11.6
13
*
N90.7
ICD-10 Finland
Vulvar cyst
15.3
11.3
18
12
ULA02
NOMESCO Finland
Kolposcopy
2.0
10.4
116
615
X01
ICPC
Genital pain female
5.4
9.7
19
36
LFC00
NOMESCO Finland
Partial excision of vulva
12.9
8.4
14
11
J02AC01
ATC
fluconazole; systemic
1.6
8.3
399
3141
A02BC05
ATC
esomeprazole; systemic
1.5
8.1
348
2669
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.0
317
2384
R01AD09
ATC
mometasone; nasal
1.5
7.6
393
3119
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
7.6
88
472
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.6
7.5
554
4744
62212
ICD-8 Finland
Infective diseases of uterus (except cervix), vagina and vulva, Bartholinitis acuta
13.5
7.4
12
9
M79.1
ICD-10 Finland
Myalgia
1.7
7.4
147
932
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
7.2
297
2239
8473
FHL
Guinea pig or gland excision
8.0
7.1
15
19
J01DA01
ATC
[U] cefalexin
1.5
7.0
497
4187
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.7
243
1778
J01CA04
ATC
amoxicillin; systemic
1.6
6.5
645
5791
UKC02
NOMESCO Finland
Cystoscopy
1.9
6.4
89
507
R03AC02
ATC
salbutamol; inhalant
1.5
6.4
459
3842
J01AA02
ATC
doxycycline; systemic
1.6
6.3
626
5594
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
6.2
243
1804
N02AX02
ATC
tramadol; systemic, rectal
1.5
6.0
327
2585

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
396
3197
1.48
6.78
2.4
2.2
—
—
—
0
0
118
741
1.70
6.08
5.2
3.9
7.35
7.36
ph
0.24
75
513
143
1005
1.52
4.58
1.3
1.3
—
—
—
0
0
412
3505
1.37
4.51
5.8
5.8
1.22
1.22
mmol/l
0.42
371
3232
530
4697
1.40
4.50
3.8
3.2
48.14
41.68
u/l
0.68
501
4391
378
3175
1.37
4.47
13.1
13.1
1.21
1.19
inr
0.26
304
2621
49
264
1.91
4.23
2.3
2.0
4227.92
4701.03
u/l
0.05
17
113
156
1134
1.47
4.23
1.3
1.2
—
—
—
0
0
620
5672
1.45
4.21
8.2
8.0
78.56
77.85
u/l
0.15
590
5360
290
2369
1.36
3.97
2.8
2.4
105.51
62.29
u/l
0.40
273
2169
446
3892
1.34
3.89
7.6
6.6
1.22
1.22
mmol/l
0.41
382
3368
20
78
2.61
3.74
1.6
1.2
—
—
—
0
0
451
3963
1.32
3.65
5.5
6.1
10.38
10.42
umol/l
0.02
427
3772
294
2437
1.33
3.57
2.3
2.2
—
—
—
0
0
746
7159
1.87
3.56
19.6
18.0
3.95
3.94
mmol/l
0.65
736
6996
732
6988
1.72
3.55
17.2
15.4
19.13
20.95
mg/l
0.92
631
5721
165
1252
1.40
3.51
1.7
1.7
1240.96
1205.13
nmol/l
0.15
123
915
26
119
2.23
3.48
1.6
1.4
26.50
28.27
u/l
0.10
21
98
475
4225
1.32
3.42
4.5
4.6
6.66
6.54
mmol/l
0.60
453
3977
49
285
1.77
3.37
2.1
3.7
—
—
—
0
0
22
97
2.30
3.22
1.5
1.3
—
—
nmol/l
—
0
0
549
5008
1.32
3.15
5.6
5.1
1000.78
2810.60
e6/l
—
9
70
18
74
2.47
3.06
2.0
2.7
—
—
—
0
0
743
7153
1.74
3.05
19.4
17.8
139.68
139.71
mmol/l
0.12
734
7006
104
746
1.45
3.01
2.3
2.2
374.19
376.28
nmol/l
0.04
90
694
63
406
1.60
2.99
2.7
3.6
7.41
7.42
ph
1.10
39
345
403
3546
1.28
2.97
2.8
2.6
—
—
estimate
—
0
0
192
1538
1.33
2.86
1.4
1.3
5.36
11.58
u/ml
1.25
75
562
217
1782
1.30
2.69
2.6
2.6
328.22
314.36
umol/l
1.11
194
1566
226
1866
1.30
2.69
2.8
2.1
—
—
—
0
0
440
3945
1.26
2.66
7.1
6.4
0.18
0.18
e9/l
0.16
379
3427
303
2604
1.27
2.61
3.5
3.4
—
0.70
—
0
10
148
1157
1.34
2.59
1.4
1.4
762.96
583.53
titre
0.29
27
272
742
7172
1.65
2.57
15.2
13.7
—
—
—
0
0
715
6857
1.49
2.56
7.0
6.3
1.88
1.89
mu/l
0.07
665
6383
202
1654
1.30
2.55
1.5
1.3
14.47
31.85
iu/ml
5.81
59
538
403
3589
1.25
2.53
7.1
6.2
27.44
28.57
%
1.47
382
3378
118
896
1.37
2.49
1.3
1.3
—
—
—
0
0
18
82
2.22
2.49
11.2
6.1
12.89
12.99
mg/l
0.03
18
75
274
2338
1.26
2.48
2.0
2.1
126.62
148.21
u/l
0.81
256
2223
36
211
1.74
2.47
2.8
3.2
2.00
2.02
index
0.01
16
101
432
3886
1.25
2.45
6.9
6.1
1.84
1.93
e9/l
1.19
374
3404
424
3810
1.25
2.42
6.8
6.1
0.56
0.55
e9/l
0.34
362
3247
755
7342
1.77
2.40
13.5
12.4
23.22
23.38
u/l
0.10
732
7128
395
3529
1.24
2.35
6.9
6.1
58.29
56.91
%
1.78
377
3347
110
835
1.37
2.33
2.1
2.5
6.78
6.37
umol/l
0.08
97
726
310
2703
1.24
2.29
3.6
3.7
22.91
64.88
ng/l
1.00
189
1852
423
3817
1.23
2.26
7.1
6.1
0.04
0.04
e9/l
0.12
362
3251
553
5139
1.26
2.25
5.7
4.9
—
2.23
—
0
7
106
809
1.36
2.18
1.8
1.6
—
—
—
0
0
102
781
1.35
2.06
1.6
1.4
—
—
—
0
0
13
56
2.34
2.05
4.1
1.6
103.79
91.66
ng/l
0.26
13
56
22
118
1.89
2.03
1.4
1.3
0.61
15.82
nmol/l
0.50
22
112
756
7378
1.69
2.03
21.9
20.2
71.70
69.63
umol/l
0.80
749
7293
391
3525
1.22
2.02
7.3
6.3
8.55
8.55
%
0.00
365
3275
469
4306
1.22
2.02
8.8
9.5
4.18
3.95
e9/l
1.16
398
3745
693
6655
1.36
2.01
6.7
6.3
39.43
38.86
mmol/mol
0.95
640
6204
405
3673
1.21
1.95
3.5
3.1
86.04
88.56
ug/l
0.15
373
3421
10
39
2.58
1.94
1.0
1.1
0.45
0.19
u/ml
—
5
18
133
1074
1.29
1.86
2.5
2.2
85.25
118.64
ug/g
1.32
110
836
388
3516
1.20
1.85
7.2
6.3
0.67
0.71
%
0.85
362
3254
120
958
1.30
1.83
3.3
3.4
4.35
4.58
e9/l
0.21
97
829
388
3522
1.20
1.80
7.1
6.2
2.75
2.75
%
0.03
362
3269
24
139
1.75
1.77
1.4
1.2
—
—
—
0
0
225
1942
1.22
1.76
1.3
1.3
0.52
1.81
u/ml
2.92
63
484
6
18
3.35
1.75
1.0
1.4
—
—
—
0
0
227
1963
1.22
1.74
2.8
2.3
2.72
2.87
mg/l
0.41
200
1672
27
164
1.67
1.70
1.5
1.8
—
—
—
0
0
70
525
1.37
1.64
1.7
1.3
—
—
—
0
0
683
6584
1.29
1.61
4.6
4.3
1.30
1.24
mmol/l
1.35
626
6006
6
20
3.01
1.58
1.5
1.1
—
—
—
0
0
89
698
1.31
1.56
1.6
1.6
—
—
—
0
0
87
681
1.31
1.55
3.1
3.3
100.91
77.18
ng/l
1.08
70
592
248
2185
1.20
1.55
2.6
3.0
1053.98
944.14
ng/l
0.17
206
1849
638
6110
1.24
1.54
5.7
5.1
14.62
14.83
pmol/l
1.33
585
5637
279
2490
1.19
1.50
3.0
2.9
25.91
28.99
u/l
2.33
260
2349
33
220
1.52
1.46
2.5
3.7
24.94
25.09
mmol/l
0.11
27
208
5
16
3.14
1.44
1.0
1.5
—
—
—
0
0
5
16
3.14
1.44
1.0
1.0
—
—
—
0
0
214
1876
1.19
1.40
3.7
3.7
95.49
94.28
%
0.30
205
1832
349
3194
1.17
1.35
2.0
1.9
1.31
1.32
mmol/l
0.12
275
2691
14
75
1.88
1.35
1.2
1.1
—
—
—
0
0
303
2744
1.17
1.34
3.5
3.3
—
—
—
0
0
95
772
1.26
1.29
4.5
2.7
1.82
1.87
%
0.16
78
684
141
1199
1.21
1.27
3.1
2.4
12.72
12.57
umol/l
0.09
133
1116
13
70
1.87
1.24
1.2
1.1
—
—
—
0
0
144
1232
1.21
1.22
3.2
2.9
0.81
0.81
mmol/l
0.15
126
1162
8
37
2.17
1.21
2.6
3.3
—
—
—
0
0
23
148
1.57
1.21
1.4
1.3
67.11
59.79
mmol/l
0.34
18
119
9
170
0.52
1.19
6.2
4.5
—
—
—
0
0
74
590
1.28
1.19
4.8
2.7
72.10
72.96
e9/l
0.07
61
423
87
708
1.26
1.18
2.6
2.2
0.21
0.21
g/l
0.18
79
671
8
38
2.12
1.18
1.6
2.0
67.78
48.08
ug/l
—
8
38
368
3407
1.15
1.18
2.4
2.1
104.44
98.84
pmol/l
0.95
181
1632
84
683
1.26
1.16
1.3
1.4
—
—
—
0
0
407
3799
1.15
1.15
2.8
2.6
79.45
80.12
nmol/l
0.18
355
3435
7
30
2.34
1.12
1.0
1.2
11.14
8.07
mm/h
—
7
30
7
30
2.34
1.12
2.6
2.5
—
—
—
0
0
8
40
2.01
1.12
4.4
1.9
—
—
—
0
0
145
1253
1.19
1.11
2.0
1.8
—
—
—
0
0
362
3359
1.14
1.10
5.4
4.5
35.83
35.97
g/l
0.21
339
3148
434
4078
1.14
1.10
4.2
4.3
0.08
0.02
estimate
0.58
85
801
19
120
1.60
1.09
1.1
1.1
9.77
1.68
u/ml
—
9
59
764
7538
1.53
1.08
26.9
24.0
264.23
261.83
e9/l
0.48
754
7398
50
384
1.32
1.07
1.9
2.2
0.00
0.01
estimate
0.50
12
114
49
376
1.32
1.06
1.3
1.9
6.78
8.14
iu/ml
—
9
86
764
7540
1.52
1.05
26.9
24.0
6.65
6.57
e9/l
0.58
749
7371
764
7540
1.52
1.05
26.9
24.0
4.40
4.39
e12/l
0.43
750
7375
764
7540
1.52
1.05
27.2
24.3
39.60
39.51
%
0.20
759
7458
9
46
1.97
1.04
1.3
1.8
6.61
8.72
ug/l
—
9
39
17
106
1.62
1.03
1.1
1.1
—
—
—
0
0
13
75
1.75
1.03
3.2
2.2
2.48
0.90
g/24h
—
6
43
196
1749
1.16
1.03
1.8
1.7
0.95
1.06
mg/l
0.38
146
1344
14
83
1.70
1.02
1.9
1.4
—
—
—
0
0
14
83
1.70
1.02
1.9
1.4
—
—
—
0
0
14
83
1.70
1.02
1.9
1.4
—
—
—
0
0
14
83
1.70
1.02
1.9
1.4
—
—
—
0
0
708
6919
1.24
1.01
5.5
5.1
1.56
1.59
mmol/l
1.23
655
6386
21
139
1.52
1.01
1.2
1.1
4.79
1.88
u/ml
0.51
11
75
18
115
1.58
1.00
1.1
1.1
1.22
0.80
u/ml
—
7
45
47
362
1.32
1.00
1.1
1.2
—
—
—
0
0
128
1106
1.19
0.99
1.7
1.6
—
—
—
0
0
711
6954
1.24
0.99
5.6
5.2
4.72
4.81
mmol/l
1.73
660
6457
703
6868
1.23
0.98
5.5
5.2
5.88
5.84
mmol/l
0.49
646
6280
26
183
1.44
0.95
1.6
1.6
6211.00
14409.31
e6/l
1.01
13
124
720
7058
1.25
0.93
6.3
6.0
2.72
2.77
mmol/l
0.90
669
6541
11
63
1.76
0.90
2.9
2.7
—
—
—
0
0
569
5886
0.88
0.87
21.4
19.4
13.72
13.62
%
1.17
561
5800
6
30
2.01
0.87
1.0
1.1
—
—
—
0
0
84
708
1.21
0.87
1.2
1.2
—
—
—
0
0
34
257
1.34
0.84
1.9
1.8
4.92
2.13
ug/l
0.36
29
230
6
32
1.88
0.82
3.0
3.7
—
—
—
0
0
14
89
1.58
0.81
1.2
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.4
—
110.39
—
0
24
6
33
1.82
0.79
2.2
1.5
173.67
144.69
mmol/24h
—
6
33
82
697
1.20
0.79
1.6
1.5
—
—
—
0
0
16
107
1.51
0.76
1.1
1.1
0.42
0.55
u/ml
—
8
51
10
59
1.70
0.76
1.2
1.2
—
—
—
0
0
43
535
0.79
0.76
2.4
2.5
—
—
—
0
0
182
1652
1.13
0.75
1.4
1.5
2.20
2.23
g/l
0.09
95
949
75
636
1.20
0.75
2.4
2.9
6.02
6.11
ph
0.37
46
431
26
193
1.36
0.74
1.2
1.3
—
—
—
0
0
128
1137
1.15
0.73
2.5
3.0
4.23
4.45
e6/l
0.06
58
507
7
39
1.80
0.72
2.9
3.4
1.57
0.82
index
—
7
39
48
390
1.25
0.72
1.9
2.1
—
—
—
0
0
5
26
1.93
0.70
2.2
2.4
38.56
41.79
g/l
—
5
26
7
42
1.67
0.68
2.0
1.4
75.57
76.19
umol/l
—
7
42
125
1115
1.14
0.68
3.1
2.4
2.43
2.37
g/l
0.49
117
1031
91
794
1.17
0.67
3.6
4.0
3.15
10.35
ug/l
4.23
76
641
422
4033
1.10
0.67
4.2
4.2
0.00
7.58
estimate
1.33
87
847
105
927
1.15
0.66
7.0
4.5
1.07
1.04
mmol/l
0.40
96
841
171
1561
1.12
0.65
1.6
1.7
59712684.83
13530779.85
pmol/l
0.35
139
1286
10
62
1.62
0.65
1.1
1.2
—
—
—
0
0
18
246
0.73
0.64
1.6
1.3
170.33
234.71
miu/ml
0.42
11
118
31
244
1.28
0.62
2.5
3.0
343.64
295.57
mg/l
0.13
14
86
13
88
1.49
0.61
1.1
1.6
—
—
—
0
0
8
51
1.57
0.60
1.0
1.0
397.50
358.57
ng/l
—
8
35
15
209
0.71
0.60
1.8
1.9
—
—
—
0
0
417
3997
1.09
0.60
4.2
4.2
0.00
0.00
estimate
0.50
87
820
8
52
1.54
0.59
1.0
1.0
813.25
703.94
ng/l
—
8
36
292
2755
1.10
0.59
3.7
4.0
79.72
98.30
e6/l
0.31
189
1858
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
229
2136
1.10
0.59
3.7
3.6
0.01
0.01
estimate
0.01
70
654
16
114
1.41
0.59
1.4
1.3
—
—
—
0
0
15
106
1.42
0.58
1.0
1.1
5.18
2.73
eliau/ml
—
5
46
266
2502
1.10
0.58
3.7
3.2
6.16
6.47
mmol/l
0.65
218
2109
86
759
1.15
0.56
5.4
6.9
1.26
1.15
mmol/l
0.10
77
634
89
788
1.15
0.56
1.9
2.2
0.00
0.03
estimate
0.78
14
147
74
647
1.16
0.55
1.2
1.2
164.07
155.67
u/ml
0.07
27
268
8
122
0.65
0.55
1.1
1.2
—
—
—
0
0
256
2410
1.09
0.54
4.4
3.9
14.07
6.93
mg/mmol
0.90
151
1352
14
99
1.42
0.54
2.2
1.3
367.30
357.27
pmol/l
0.04
14
86
13
91
1.44
0.53
2.9
1.7
36.52
47.36
u/ml
0.08
13
91
6
39
1.54
0.53
1.7
3.5
761.83
635.15
u/ml
—
6
39
16
117
1.38
0.52
1.4
1.2
—
—
—
0
0
30
242
1.25
0.51
1.5
1.4
0.47
0.31
mg/l
—
8
85
67
587
1.15
0.50
7.4
7.1
—
—
—
0
0
301
2865
1.08
0.49
3.6
3.5
2.37
2.37
mmol/l
0.03
257
2604
248
2343
1.09
0.48
3.1
3.3
141.26
48.13
e6/l
0.61
179
1764
46
392
1.18
0.48
1.1
1.1
—
187.73
—
0
11
55
632
0.86
0.47
3.1
3.6
1.23
1.24
mmol/l
0.47
46
542
18
137
1.32
0.47
1.3
1.5
—
—
—
0
0
173
1612
1.09
0.46
2.6
2.7
5.45
7.98
e6/l
2.62
153
1475
113
1031
1.11
0.46
3.0
2.4
21.58
21.39
%
0.05
102
963
84
753
1.13
0.46
2.2
2.3
35.45
37.23
u/l
0.14
67
625
5
82
0.61
0.46
1.4
2.1
31.20
31.40
pg
—
5
82
32
384
0.83
0.45
2.7
3.5
1.02
1.02
ratio
0.11
27
354
73
649
1.14
0.45
3.4
4.2
0.00
0.09
%
2.96
15
156
7
51
1.38
0.44
1.1
1.6
—
—
—
0
0
21
166
1.27
0.43
3.3
2.3
12.98
7.21
pmol/l
0.66
21
166
5
31
1.62
0.43
4.0
1.5
—
—
—
0
0
5
31
1.62
0.43
1.4
1.4
14.88
14.47
pmol/l
—
5
24
5
31
1.62
0.43
2.0
1.9
—
—
—
0
0
6
94
0.64
0.42
2.2
2.8
—
—
—
0
0
17
131
1.30
0.42
5.8
3.5
—
—
—
0
0
149
1386
1.09
0.42
2.6
2.8
449.25
490.01
mosm/kgh2o
1.76
124
1213
81
731
1.12
0.41
1.3
1.4
—
—
—
0
0
15
114
1.32
0.41
1.3
1.3
264.75
244.58
u/ml
—
8
66
15
114
1.32
0.41
1.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
29.35
—
0
17
42
362
1.17
0.40
7.0
9.0
15.96
15.60
%
0.46
42
349
12
88
1.37
0.40
1.2
1.1
—
—
—
0
0
249
2372
1.07
0.39
3.7
3.3
65.65
31.06
mg/l
1.04
147
1366
111
1022
1.10
0.39
2.0
1.9
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
869.40
1733.43
miu/ml
—
5
35
71
639
1.12
0.38
5.5
7.4
117.63
118.39
g/l
0.12
71
625
84
764
1.11
0.38
5.6
6.9
7.42
7.42
ph
0.01
43
434
73
659
1.12
0.37
3.8
4.5
0.07
0.09
%
0.08
14
145
16
125
1.29
0.37
1.0
1.1
—
—
—
0
0
16
125
1.29
0.37
1.0
1.1
—
—
—
0
0
65
584
1.12
0.36
1.4
1.3
—
—
—
0
0
72
651
1.12
0.36
3.5
4.1
0.87
0.77
%
0.09
15
178
49
432
1.14
0.36
1.1
1.3
—
—
—
0
0
158
1678
0.93
0.35
3.2
2.7
2.46
2.46
mmol/l
0.06
139
1521
212
2016
1.07
0.35
3.1
3.2
0.29
0.42
e6/l
0.64
145
1451
14
108
1.30
0.35
2.1
1.4
25.69
85.16
mu/l
0.72
14
99
15
117
1.29
0.35
1.0
1.0
—
—
—
0
0
6
43
1.40
0.35
2.5
1.8
314.00
203.09
e6/l
—
6
35
335
3237
1.06
0.34
3.8
3.7
6.27
6.28
ph
0.06
185
1772
19
232
0.81
0.34
1.3
1.2
0.93
0.91
g/l
0.09
19
232
6
45
1.34
0.34
1.0
1.0
—
—
—
0
0
13
100
1.31
0.33
1.1
1.0
2.06
2.24
u/ml
—
6
44
6
47
1.28
0.32
1.0
1.2
—
—
—
0
0
22
183
1.21
0.32
2.4
1.9
132.87
127.82
g/l
0.43
15
148
16
129
1.25
0.30
1.4
1.4
—
—
—
0
0
60
544
1.11
0.30
1.5
1.3
—
—
—
0
0
133
1253
1.07
0.29
2.6
2.9
1.55
1.26
e6/l
0.27
65
629
61
556
1.11
0.28
2.3
2.5
22.46
21.43
au/ml
—
10
50
45
403
1.12
0.28
2.7
2.4
—
—
—
0
0
74
683
1.09
0.27
3.4
4.2
1.13
0.99
%
0.06
16
191
161
1690
0.94
0.27
4.4
4.7
—
—
—
0
0
8
65
1.23
0.27
1.5
1.2
—
—
—
0
0
69
636
1.09
0.26
6.2
6.1
1.13
1.28
mmol/l
1.25
69
625
5
73
0.68
0.26
1.2
1.1
115.00
113.41
pmol/l
—
5
73
47
425
1.11
0.26
1.9
1.8
—
—
—
0
0
23
198
1.17
0.25
4.3
2.2
58.70
58.77
%
0.01
23
190
11
87
1.27
0.24
1.4
1.1
—
—
—
0
0
30
265
1.14
0.24
1.3
1.2
—
—
—
0
0
17
143
1.19
0.23
3.1
3.8
22.52
19.13
mg/l
0.15
12
93
36
323
1.12
0.23
1.3
1.3
—
—
—
0
0
169
1761
0.95
0.23
4.5
4.4
1.02
1.87
kg/l
0.50
120
1179
212
2047
1.05
0.22
1.4
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
4.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
18
154
1.17
0.21
1.1
1.5
—
—
—
0
0
15
126
1.19
0.21
5.9
7.1
11.00
11.04
mmol/l
0.02
15
113
15
126
1.19
0.21
6.0
7.1
104.07
105.31
mmol/l
0.48
15
113
49
532
0.92
0.21
2.1
2.3
4.13
6.75
ug/l
1.55
41
464
22
192
1.15
0.21
1.0
1.3
445.82
498.94
mg/l
0.61
22
182
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
1.36
—
0
7
190
1834
1.05
0.20
4.3
3.8
—
—
—
0
0
100
948
1.06
0.20
1.7
1.4
—
—
—
0
0
13
155
0.84
0.20
1.2
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
22
193
1.14
0.19
2.4
2.5
—
—
—
0
0
6
51
1.18
0.19
1.2
1.2
—
—
—
0
0
11
90
1.23
0.19
1.2
1.1
—
—
—
0
0
6
53
1.13
0.18
1.7
1.3
—
—
—
0
0
7
59
1.19
0.18
1.1
1.4
—
—
—
0
0
21
186
1.13
0.17
1.0
1.2
—
—
—
0
0
5
68
0.73
0.17
1.2
1.1
6.52
6.72
mmol/l
—
5
62
15
173
0.86
0.17
1.6
1.4
—
—
—
0
0
29
265
1.10
0.15
1.8
1.8
19.54
20.39
s
0.81
24
238
15
171
0.87
0.14
1.6
1.4
1.16
1.30
mm
—
10
115
7
90
0.78
0.14
1.3
1.7
—
—
—
0
0
144
1397
1.04
0.13
4.0
3.8
226.98
365.40
ng/l
0.35
102
1038
9
106
0.85
0.13
1.8
1.4
—
—
—
0
0
20
221
0.90
0.13
1.5
1.1
1.49
1.64
g/l
1.85
20
221
10
85
1.18
0.12
1.2
1.5
16.45
21.88
ng/l
—
10
85
59
618
0.95
0.11
3.0
2.9
65.28
67.05
g/l
0.78
53
570
260
2644
0.98
0.11
3.0
3.2
—
—
—
0
0
29
311
0.93
0.10
1.0
1.1
—
—
—
0
0
16
177
0.90
0.10
1.6
1.5
—
—
—
0
0
22
203
1.09
0.09
2.4
1.3
—
—
—
0
0
192
1884
1.03
0.09
3.9
4.1
—
0.06
—
0
17
25
268
0.93
0.09
4.5
4.8
1.02
0.88
%
1.31
25
251
22
204
1.08
0.08
2.9
1.4
—
—
—
0
0
22
204
1.08
0.08
2.9
1.4
—
—
—
0
0
71
686
1.04
0.08
6.5
3.0
2.14
2.01
mmol/l
0.11
63
600
6
56
1.07
0.08
1.3
1.2
506.00
374.74
nmol/l
—
6
50
12
107
1.12
0.08
4.2
6.0
325.17
371.06
umol/l
0.56
12
95
28
263
1.07
0.08
1.2
1.4
278.50
299.56
ug/g
0.15
14
155
22
205
1.08
0.08
2.9
1.4
—
—
—
0
0
7
68
1.03
0.08
2.9
2.0
—
—
—
0
0
8
75
1.07
0.07
2.0
1.3
—
—
—
0
0
8
77
1.04
0.07
1.8
3.0
—
—
—
0
0
13
118
1.10
0.07
1.3
1.1
2.50
2.58
u/ml
—
6
48
231
2339
0.98
0.06
6.1
6.3
—
—
—
0
0
54
558
0.97
0.06
6.1
3.3
4.48
4.49
pmol/l
0.02
48
493
226
2233
1.02
0.06
4.1
4.3
0.00
0.00
estimate
1.08
82
785
15
162
0.92
0.06
3.4
1.8
—
—
—
0
0
13
119
1.09
0.06
1.0
1.1
—
—
—
0
0
16
172
0.93
0.06
3.2
3.1
60.44
59.24
%
0.13
16
172
28
267
1.05
0.05
3.0
2.0
4.17
25.75
iu/l
—
10
106
31
297
1.05
0.05
4.0
4.5
1.86
1.52
%
0.68
31
281
245
2427
1.01
0.05
3.9
3.8
7.40
7.40
ph
0.10
168
1749
332
3297
1.01
0.04
11.3
11.0
0.00
0.00
e9/l
1.70
266
2682
44
427
1.03
0.04
5.5
2.9
24.79
24.48
mmol/l
0.27
44
419
29
300
0.97
0.03
1.1
1.1
—
—
—
0
0
41
400
1.03
0.02
5.4
6.7
25.39
24.73
mmol/l
0.66
41
383
21
202
1.04
0.02
17.5
8.4
—
—
—
0
0
84
850
0.99
0.02
1.9
1.8
—
—
—
0
0
15
143
1.05
0.01
7.1
1.6
—
—
—
0
0
71
717
0.99
0.01
6.5
3.0
5.87
5.81
kpa
0.21
71
697
22
214
1.03
0.00
4.4
3.9
2.07
3.91
ratio
0.46
16
120
25
256
0.98
0.00
1.1
1.2
—
—
—
0
0
42
426
0.99
0.00
1.5
1.3
19.31
28.77
iu/l
1.45
37
371
17
165
1.03
0.00
3.3
1.4
—
—
—
0
0
17
165
1.03
0.00
1.1
1.5
261.92
16.58
e6/l
0.46
12
117
11
106
1.04
0.00
3.4
1.4
—
—
—
0
0
35
345
1.02
0.00
1.5
1.5
1133.12
1044.03
mu/l
0.20
25
276
18
177
1.02
0.00
1.0
1.2
3.69
3.77
mmol/l
0.20
18
167
53
533
0.99
0.00
1.5
1.8
3.34
3.49
mmol/l
0.46
34
380
14
139
1.01
0.00
3.4
3.2
4.60
4.31
e9/l
0.15
14
139
20
199
1.01
0.00
1.2
1.1
—
—
—
0
0
299
2987
1.00
0.00
4.2
4.1
0.01
0.04
estimate
0.86
70
657
60
601
1.00
0.00
3.8
4.0
—
—
—
0
0
225
2249
1.00
0.00
1.8
1.7
21.73
21.70
nmol/l
0.01
185
1876
8
84
0.95
0.00
1.0
1.2
—
—
—
0
0
6
63
0.95
0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
82.29
—
0
7
71
710
1.00
-0.00
6.6
3.1
7.38
7.38
ph
0.34
41
383
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
2.6
1.6
39.38
42.50
%
—
5
50
0
5
0.00
-0.00
0.0
1.0
—
0.16
—
0
5
9
90
1.00
-0.00
2.2
2.8
—
—
—
0
0
7
77
0.91
-0.00
1.9
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
506.35
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
19
190
1.00
-0.00
3.1
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.1
—
7.91
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
0.03
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
73
0.96
-0.00
1.4
1.2
33.24
34.67
g/l
—
7
66
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_VAGINA and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_VAGINA 0.981 [0.85, 1.14] 0.799
Birth year 0.997 [0.99, 1.01] 0.46

During the follow-up period (1.1.1998 — 31.12.2019), 326 out of 2726 females with CD2_BENIGN_VAGINA died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_VAGINA.

N-year risk Females Males
1 0.083% No data
5 0.496% No data
10 1.422% No data
15 2.908% No data
20 5.287% No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_VAGINA – Benign neoplasm: Vulva

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data