splenic disease: A disease involving the spleen.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
757 |
4. Check minimum number of eventsNone |
757 |
5. Include endpoints |
780 |
6. Filter based on genotype QC (FinnGen only) |
664 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D70-D77
- Name in latin
- Morbi lienis
Similar endpoints
↥List of similar endpoints to
Diseases of spleen
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4031 | 1960 | 2041 |
| Only index persons | 3439 | 1713 | 1726 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 59.75 | 60.79 | 58.66 |
| Only index persons | 58.74 | 59.31 | 58.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 664 | 333 | 331 |
| Unadjusted period prevalence (%) | 0.13 | 0.12 | 0.15 |
| Median age at first event (years) | 61.51 | 58.02 | 65.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 700
- Matched controls
- 7000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.5
ICD-10 Finland
Infarction of spleen
+∞
263.7
236
*
D73.1
ICD-10 Finland
Hypersplenism
+∞
173.3
159
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
91.5
153.9
81
10
XW000
NOMESCO Finland
Bone marrow biopsy
16.1
148.4
136
103
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.6
118.8
255
560
D73.9
ICD-10 Finland
Disease of spleen, unspecified
+∞
95.0
89
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
10.1
88.6
108
124
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.7
75.1
165
358
D73.4
ICD-10 Finland
Cyst of spleen
799.1
74.7
72
*
D73.8
ICD-10 Finland
Other diseases of spleen
+∞
65.7
62
*
D73.0
ICD-10 Finland
Hyposplenism
+∞
65.7
62
*
WW500
NOMESCO Finland
Blood transfusion
8.6
64.3
87
113
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.8
62.9
171
441
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.6
61.2
329
1373
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.0
59.5
151
367
JN3AD
NOMESCO Finland
Abdominal CT examination
4.1
55.0
187
567
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
19.6
49.5
39
21
L01XX05
ATC
hydroxycarbamide; oral
17.4
49.1
41
25
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
11.4
48.5
52
49
D64.9
ICD-10 Finland
Anaemia, unspecified
4.3
48.2
146
404
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
131.5
46.4
49
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
18.5
45.8
37
21
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
163.8
44.4
46
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
44.3
448
2567
R50.9
ICD-10 Finland
Fever, unspecified
3.6
44.0
185
640
C03CA01
ATC
furosemide; systemic
3.0
43.6
305
1427
WW200
NOMESCO Finland
Immunization
9.0
43.0
55
66
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.1
41.7
96
212
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
8.3
40.9
56
73
JN4AD
NOMESCO Finland
Body CT examination
3.7
40.3
153
493
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.8
39.7
348
1814
M04AA01
ATC
allopurinol; systemic
3.6
39.2
158
529
J01MA12
ATC
levofloxacin; systemic
3.2
38.2
200
785
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
37.5
230
986
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
37.3
191
739
ZX120
NOMESCO Finland
Intravenous
4.1
37.1
117
330
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
13.1
36.0
35
28
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.1
35.6
196
788
JN4BD
NOMESCO Finland
Extensive body CT
3.6
33.3
124
391
TPH07
NOMESCO Finland
Cathetrisation of artery
3.4
31.2
134
462
D70.89
ICD-10 Finland
Neutropenic splenomegaly
115.3
30.9
33
*
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
9.1
30.4
38
44
N28.0
ICD-10 Finland
Ischaemia and infarction of kidney
86.5
30.0
33
*
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
7.5
30.0
44
62
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
6.3
29.9
52
88
D73.3
ICD-10 Finland
Abscess of spleen
+∞
29.4
28
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
28.7
249
1247
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.4
28.7
76
187
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.7
27.5
188
836
B01AB05
ATC
enoxaparin; parenteral
2.4
25.4
271
1476
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
23.8
179
828
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
23.7
118
440
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.6
23.6
86
265
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
56.0
23.2
27
5
N02AA05
ATC
oxycodone; systemic
2.5
22.8
179
844
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
124.1
22.7
24
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
7.8
22.7
32
43
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
7.1
22.3
34
50
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.3
22.2
38
63
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
22.0
119
464
UJF32
NOMESCO Finland
Coloscopy
2.3
21.8
231
1240
WX892
NOMESCO Finland
Monitored bed care
3.3
21.0
86
285
B01AB10
ATC
tinzaparin; parenteral
2.9
20.8
112
435
A10AE04
ATC
insulin glargine; parenteral
3.0
20.8
105
394
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
6.0
20.4
37
65
H02AB06
ATC
prednisolone; systemic
2.1
20.3
377
2501
C03DA01
ATC
spironolactone; oral
2.7
20.1
125
523
A10AB05
ATC
insulin aspart; parenteral
3.2
19.9
87
300
A41.9
ICD-10 Finland
Sepsis, unspecified
4.6
19.5
47
107
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.0
19.3
58
156
C07AB07
ATC
bisoprolol; oral
2.1
19.3
383
2588
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
19.2
215
1170
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.6
19.0
47
109
TK800
NOMESCO Finland
Hemodialysis
6.0
19.0
34
59
A02BC02
ATC
pantoprazole; systemic
2.2
18.8
514
3892
I50.9
ICD-10 Finland
Heart failure, unspecified
2.5
18.8
136
612
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.6
18.2
44
100
B03XA02
ATC
darbepoetin alfa; parenteral
5.9
18.2
33
58
JN6AD
NOMESCO Finland
CT of torso and neck
6.9
18.0
28
42
B01AA03
ATC
warfarin; systemic
2.3
17.8
160
793
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
17.7
214
1194
JAH00
NOMESCO Finland
Laparotomy
4.8
17.7
41
90
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.0
17.6
51
134
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.2
17.5
72
239
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.0
17.4
81
289
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
17.3
138
648
D45
ICD-10 Finland
Polycythaemia vera
15.3
17.3
28
19
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
5.0
17.2
38
80
K86.3
ICD-10 Finland
Pseudocyst of pancreas
26.4
17.0
23
9
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
65.0
16.8
19
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
7.5
16.6
24
33
Z3231
NOMESCO Finland
Registered nurse
2.1
16.6
219
1259
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
28.3
16.6
22
8
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
16.4
263
1620
N02AX02
ATC
tramadol; systemic, rectal
1.9
16.1
334
2242
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.1
16.0
69
235
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
6.3
16.0
27
44
A05AA02
ATC
ursodeoxycholic acid; oral
5.9
16.0
29
51
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
5.7
15.8
30
55
D73.2
ICD-10 Finland
Chronic congestive splenomegaly
+∞
15.7
15
*
D75.2
ICD-10 Finland
Essential thrombocytosis
163.5
15.5
16
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.9
15.4
47
128
AA1AD
NOMESCO Finland
CT of head and brain
2.0
15.3
240
1461
R4110
NOMESCO Finland
Physiotherapy
2.0
15.3
221
1308
ZXD05
NOMESCO Finland
Urgent procedure
2.0
15.1
235
1426
SPAT1255
SPAT
Intravenous administration of medicine
3.0
15.0
68
239
WX402
NOMESCO Finland
General anaesthesia
2.1
14.9
181
1004
Z2221
NOMESCO Finland
Medical doctor
2.0
14.7
209
1227
PD5AD
NOMESCO Finland
CT of aorta
4.6
14.6
35
79
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.3
14.5
57
184
L03AA02
ATC
filgrastim; parenteral
4.6
14.4
35
80
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
14.3
117
553
127
Kela drug reimbursment
Transplant complication
6.0
14.1
25
43
A03FA01
ATC
metoclopramide; systemic, rectal
2.1
14.1
174
969
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
14.0
152
806
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.2
14.0
57
188
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
13.9
384
2783
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
54.5
13.9
16
*
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
10.8
13.8
26
25
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
13.7
162
887
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
76.7
13.6
15
*
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
76.7
13.6
15
*
ZXE00
NOMESCO Finland
One hour or less
1.9
13.6
283
1874
S36.0
ICD-10 Finland
Injury of spleen
26.3
13.4
18
7
JAH01
NOMESCO Finland
Laparoscopy
3.7
13.4
44
126
WX872
NOMESCO Finland
Intensive care
3.3
13.2
52
168
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.1
13.1
37
95
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.3
13.1
34
82
K83.0
ICD-10 Finland
Cholangitis
6.3
13.0
22
36
A46
ICD-10 Finland
Erysipelas
2.2
13.0
128
652
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
5.7
13.0
24
43
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
19.5
13.0
19
10
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
12.9
97
440
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
12.8
130
670
N18.8
ICD-10 Finland
Other chronic renal failure
4.9
12.7
28
59
TGC00
NOMESCO Finland
Bronchial lavation
4.0
12.7
36
93
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
12.6
12.7
22
18
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
6.1
12.7
22
37
9689/3-C42.2
ICD-O-3
Splenic marginal zone B-cell lymphoma of spleen
+∞
12.5
12
*
374
Kela drug reimbursment
Ruxolitinib
132.3
12.5
13
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
132.3
12.5
13
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.8
12.5
63
235
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.4
12.4
90
402
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
12.4
112
550
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
12.2
276
1859
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.8
12.1
37
101
R11
ICD-10 Finland
Nausea and vomiting
2.5
12.1
82
355
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.0
12.0
35
92
A06AD11
ATC
lactulose; oral
2.2
12.0
120
613
J01DB01
ATC
cefalexin; oral
2.1
12.0
588
4992
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.7
11.9
38
107
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
9.2
11.8
24
27
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.6
11.8
28
63
J01MA02
ATC
ciprofloxacin; systemic
1.8
11.7
286
1965
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
19.3
11.6
17
9
Z51.5
ICD-10 Finland
Palliative care
2.4
11.6
81
355
174
Kela drug reimbursment
Ruxolitinib
121.9
11.5
12
*
P01AB01
ATC
metronidazole; oral, rectal
1.8
11.4
284
1959
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.8
11.4
35
96
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
15.4
11.4
18
12
JKA20
NOMESCO Finland
Cholecystectomy
4.1
11.3
31
78
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
35.7
11.3
14
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.9
11.3
56
207
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.1
11.3
49
168
L04AA06
ATC
mycophenolic acid; systemic
4.9
11.3
25
53
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.4
11.2
40
121
A07AA09
ATC
vancomycin; oral
5.7
11.2
21
38
B99
ICPC
Blood/lymph/spleen disease other
25.5
11.2
15
6
I50.0
ICD-10 Finland
Congestive heart failure
2.6
10.9
67
276
UJK02
NOMESCO Finland
ERCP
4.1
10.9
30
76
JLC10
NOMESCO Finland
Distal pancreatectomy
28.5
10.8
14
5
TQW11
NOMESCO Finland
Vacuum treatment of wound
4.3
10.6
27
64
K50.9
ICD-10 Finland
Crohn disease, unspecified
5.1
10.6
22
44
L01EJ01
ATC
ruxolitinib; oral
111.6
10.4
11
*
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
10.4
86
406
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
3.8
10.4
32
88
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.3
10.3
40
128
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
23.8
10.3
14
6
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
10.1
251
1717
R06.0
ICD-10 Finland
Dyspnoea
1.8
10.1
206
1334
120
Kela drug reimbursment
Hypogammaglobulinaemia
40.7
10.0
12
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.6
10.0
57
227
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
7.8
10.0
22
29
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
5.2
9.9
20
39
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
9.9
170
1045
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
4.5
9.9
24
55
K92.0
ICD-10 Finland
Haematemesis
3.9
9.9
29
77
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
4.8
9.8
22
47
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.9
9.8
48
176
K86.1
ICD-10 Finland
Other chronic pancreatitis
9.7
9.8
19
20
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.9
9.7
140
812
J01MA14
ATC
moxifloxacin; systemic
2.3
9.7
74
338
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
11.6
9.6
17
15
WZC30
NOMESCO Finland
Teaching
1.9
9.4
130
743
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
30.5
9.4
12
*
GD1AD
NOMESCO Finland
Thorax CT examination
2.5
9.4
59
246
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
5.0
9.4
20
41
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.1
9.3
93
473
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
8.8
9.3
19
22
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
13.9
9.2
15
11
R04.0
ICD-10 Finland
Epistaxis
2.3
9.1
68
307
WX882
NOMESCO Finland
High dependency care
3.6
9.0
29
82
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.8
9.0
46
173
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.6
8.9
51
203
I81
ICD-10 Finland
Portal vein thrombosis
12.7
8.9
15
12
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
3.6
8.9
29
83
K55.0
ICD-10 Finland
Acute vascular disorders of intestine
9.6
8.8
17
18
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.9
8.8
42
152
S97
ICPC
Chronic ulcer skin
2.4
8.8
59
254
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
7.3
8.8
20
28
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.7
8.8
28
79
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
8.7
252
1779
L04AD02
ATC
tacrolimus; systemic
7.8
8.7
19
25
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.8
8.7
26
70
M10.9
ICD-10 Finland
Gout, unspecified
2.4
8.7
60
262
ZX112
NOMESCO Finland
Subcutaneous
4.0
8.7
24
61
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
8.6
151
930
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.4
8.6
31
95
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
9.1
8.6
17
19
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.5
8.5
52
214
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
4.3
8.5
22
53
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
3.5
8.4
29
86
Z3226
NOMESCO Finland
Physiotherapist
1.8
8.4
129
762
A41.8
ICD-10 Finland
Other specified sepsis
4.1
8.4
23
58
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
8.4
158
993
L03AA13
ATC
pegfilgrastim; parenteral
2.9
8.3
38
134
L01XX35
ATC
anagrelide; oral
+∞
8.3
8
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
8.3
104
574
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
10.9
8.3
15
14
B01AB04
ATC
dalteparin; parenteral
2.8
8.3
42
157
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.9
8.3
39
140
L04AD01
ATC
ciclosporin; systemic
4.3
8.2
21
50
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.8
8.2
42
158
K65.0
ICD-10 Finland
Acute peritonitis
7.7
8.2
18
24
Z49.1
ICD-10 Finland
Extracorporeal dialysis
4.8
8.2
18
38
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
2.8
8.1
41
153
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
8.1
103
572
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
9.1
8.1
16
18
R10.0
ICD-10 Finland
Acute abdomen
3.4
8.0
29
89
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.8
8.0
39
143
D64.8
ICD-10 Finland
Other specified anaemias
4.4
8.0
20
47
N03AX16
ATC
[U] pregabalin
1.7
7.9
159
1016
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
13.2
7.9
13
10
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
7.9
97
533
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
7.8
137
843
K29.7
ICD-10 Finland
Gastritis, unspecified
3.0
7.8
33
112
KH1AD
NOMESCO Finland
CT of urinary organs
3.0
7.8
33
112
K76.6
ICD-10 Finland
Portal hypertension
45.5
7.7
9
*
N05CF01
ATC
zopiclone; oral
1.6
7.6
218
1526
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
8.2
7.6
16
20
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
18.6
7.6
11
6
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
18.6
7.6
11
6
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.8
7.6
39
147
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
3.4
7.6
27
82
K86.01
ICD-10 Finland
Late effects of pancreatitis caused by alcohol
25.3
7.6
10
*
3AC01, ,
NOMESCO Finland
9.0
7.6
15
17
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
9.0
7.6
15
17
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.6
7.6
42
165
R53
ICD-10 Finland
Malaise and fatigue
1.7
7.5
183
1230
UJF92
NOMESCO Finland
Capsular endoscopy
4.0
7.5
21
54
E87.5
ICD-10 Finland
Hyperkalaemia
4.0
7.5
21
54
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.4
7.4
26
78
XF600
NOMESCO Finland
Bloodpressure measurement
2.5
7.4
48
203
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
3.1
7.4
31
104
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
7.4
190
1293
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
7.4
54
242
A02BC05
ATC
esomeprazole; systemic
1.6
7.4
273
2029
N02BE01
ATC
paracetamol; systemic, rectal
1.9
7.3
619
5585
JJ1CE
NOMESCO Finland
Liver, bile duct and pancreas endoscopic ultrasound examination
11.0
7.3
13
12
WX002
NOMESCO Finland
Sedation and analgesia
1.8
7.3
133
825
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
7.3
7
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.1
7.3
68
337
K76.9
ICD-10 Finland
Liver disease, unspecified
6.3
7.3
18
29
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.9
7.3
34
122
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.1
7.2
71
359
I50.1
ICD-10 Finland
Left ventricular failure
2.6
7.2
43
175
SPAT1262
SPAT
Handing over of treatment supplies
1.8
7.2
121
733
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
7.2
491
4171
H02AB04
ATC
methylprednisolone; systemic
1.9
7.2
103
594
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
30.3
7.2
9
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.9
7.2
34
123
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
12.2
7.1
12
10
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
8.9
7.1
14
16
ZX108
NOMESCO Finland
Inhalation
10.2
7.1
13
13
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.2
7.0
61
294
205
Kela drug reimbursment
Chronic hypertension
1.6
7.0
177
1198
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
7.0
198
1379
K92.1
ICD-10 Finland
Melaena
2.5
6.9
44
185
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
6.9
127
789
A04AA01
ATC
ondansetron; systemic, rectal
2.2
6.9
61
296
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
13.9
6.9
11
8
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
6.9
414
3402
B01AF02
ATC
apixaban; oral
1.8
6.9
100
580
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
5.7
6.8
18
32
D75.1
ICD-10 Finland
Secondary polycythaemia
40.5
6.8
8
*
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
16.9
6.8
10
6
JLB28
NOMESCO Finland
Endoscopic internal drainage of pancreatic duct
16.9
6.8
10
6
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.5
6.7
23
68
R4190
NOMESCO Finland
Nutritional therapy
2.7
6.7
35
133
TPH40
NOMESCO Finland
Insertion of a long peripheral venous catheter
7.3
6.7
15
21
N06AX11
ATC
mirtazapine; oral
1.6
6.7
229
1662
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.7
6.7
36
139
B03BA03
ATC
hydroxocobalamin; parenteral
2.4
6.7
45
194
PG1PT
NOMESCO Finland
Extensive endovascular embolisation for bleeding with radiological guidance not elsewhere classified
22.8
6.7
9
*
JLW98
NOMESCO Finland
Other transluminal endoscopic operation on pancreas
22.8
6.7
9
*
A04AA02
ATC
granisetron; systemic, transdermal
2.3
6.6
48
214
A40.8
ICD-10 Finland
Other streptococcal sepsis
5.6
6.6
18
33
R02
ICPC
Shortness of breath/dyspnoea
1.8
6.6
96
555
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
6.6
172
1170
ZYC01
NOMESCO Finland
Remote contact by phone
2.2
6.6
53
247
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
6.6
296
2278
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.1
6.6
61
301
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.1
6.6
61
301
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
12.4
6.6
11
9
Z94.4
ICD-10 Finland
Liver transplant status
12.4
6.6
11
9
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
4.2
6.6
17
41
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
6.6
172
1173
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
10.2
6.6
12
12
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
10.2
6.6
12
12
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.4
6.5
44
190
D68.8
ICD-10 Finland
Other specified coagulation defects
6.9
6.5
15
22
H02AB07
ATC
prednisone; oral
1.9
6.5
91
520
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.4
6.5
46
203
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.0
6.5
28
96
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
4.0
6.5
18
46
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
6.5
148
975
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
70.5
6.4
7
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
2.8
6.4
32
119
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
6.6
6.4
15
23
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.3
6.4
45
199
V03AE01
ATC
polystyrene sulfonate; oral
5.3
6.4
18
35
J01FF01
ATC
clindamycin; systemic
1.6
6.3
185
1293
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
6.3
97
572
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
18.2
6.3
9
5
Z2446
NOMESCO Finland
Social worker
2.2
6.3
53
253
2895A
ICD-9 Finland
Other diseases of blood and blood-forming organs, Other diseases of spleen
+∞
6.3
6
*
JM1AT
NOMESCO Finland
Cytology of spleen with ultrasound guidance
+∞
6.3
6
*
JMW97
NOMESCO Finland
Other laparoscopic operation on spleen
+∞
6.3
6
*
SPAT1263
SPAT
Sampling
1.5
6.2
276
2114
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.5
6.2
38
157
R18
ICD-10 Finland
Ascites
3.5
6.2
21
62
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
6.1
275
2109
R60.0
ICD-10 Finland
Localized oedema
1.8
6.1
89
515
N19
ICD-10 Finland
Unspecified kidney failure
2.5
6.1
36
146
T81.9
ICD-10 Finland
Unspecified complication of procedure
3.8
6.1
18
48
A12AA04
ATC
calcium carbonate; oral
3.8
6.1
18
48
D07AC01
ATC
betamethasone; topical
1.5
6.1
241
1799
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
4.2
6.1
16
39
A07AA11
ATC
rifaximin; oral
12.7
6.1
10
8
A11CC03
ATC
alfacalcidol; systemic
3.2
6.1
23
73
D47.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
10.1
6.0
11
11
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
6.1
6.0
15
25
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
5.6
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
330
696
8.08
166.41
8.3
4.4
287.21
240.61
u/l
3.04
322
663
225
552
5.53
90.45
6.8
2.9
83.32
69.08
e9/l
4.25
176
410
213
512
5.54
87.37
3.9
2.5
10.80
10.87
g/l
0.07
198
477
99
106
10.71
85.38
3.1
3.0
709.08
3506.00
u/ml
—
12
7
109
136
9.31
83.75
7.8
5.6
183.57
461.89
iu/ml
0.77
21
18
283
919
4.49
79.10
4.5
2.6
22.61
23.05
%
0.17
270
863
119
181
7.72
77.22
3.6
2.8
199.16
188.82
%
0.47
113
174
289
992
4.26
74.19
4.3
2.6
2.23
2.29
g/l
1.02
275
925
288
998
4.20
72.74
3.9
2.2
31.36
29.60
s
2.63
281
974
298
1066
4.13
71.82
4.4
2.6
11.76
13.14
umol/l
2.33
284
996
173
409
5.29
71.20
2.3
1.6
1.13
1.44
g/l
0.98
160
384
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
119
205
6.79
68.47
4.3
2.7
0.29
0.33
iu/ml
0.65
86
105
264
894
4.14
68.20
9.5
6.1
1.07
1.02
mmol/l
1.45
250
824
210
622
4.39
64.78
3.9
2.4
0.19
0.21
g/l
2.53
200
584
564
3291
4.67
63.28
16.8
6.8
14.10
11.61
umol/l
3.56
555
3148
138
299
5.50
62.26
2.7
1.9
1.25
1.51
g/l
2.06
114
273
199
584
4.36
61.87
12.5
8.1
11.15
9.77
mmol/l
1.57
193
559
506
2769
3.99
61.59
12.5
5.2
33.78
35.71
g/l
9.29
492
2610
185
518
4.50
61.13
2.1
2.8
64.74
66.57
g/l
1.89
178
484
98
157
7.10
60.18
1.8
1.6
—
—
—
0
0
282
1085
3.68
59.08
5.4
3.5
0.80
0.82
mmol/l
1.21
271
1033
358
1626
3.46
57.28
3.3
2.2
3.74
2.87
mg/l
5.17
318
1406
570
3537
4.29
54.04
21.6
9.3
4.62
4.15
e9/l
2.03
528
3094
207
698
3.79
52.06
7.6
3.3
10.41
8.54
umol/l
0.63
193
624
102
197
5.89
51.78
2.2
3.5
1.55
2.45
ratio
0.98
61
114
72
97
8.16
51.37
1.3
1.2
118.74
36.53
u/l
0.85
60
85
106
217
5.58
50.50
2.2
3.8
44.31
41.40
mg/l
0.09
89
186
106
217
5.58
50.50
2.2
3.7
55.87
76.69
mg/l
0.32
88
185
393
1994
3.21
50.41
5.4
2.7
65.56
100.61
u/l
0.42
374
1877
336
1559
3.22
50.28
11.7
4.3
80.74
89.65
%
8.24
329
1534
61
69
9.59
50.00
1.1
1.0
—
—
—
0
0
496
2913
3.41
48.91
26.1
15.0
1.36
1.26
inr
3.61
453
2419
41
27
16.07
47.18
2.1
1.7
—
—
—
0
0
478
2787
3.25
46.87
14.8
6.9
1.20
1.21
mmol/l
3.22
455
2581
110
250
5.03
46.39
2.4
1.8
2.54
2.70
ug/l
0.04
101
223
511
3111
3.38
46.24
16.5
7.7
1.20
1.21
mmol/l
1.78
447
2710
85
154
6.14
45.96
4.9
3.0
39.78
34.04
umol/l
1.19
77
140
331
1595
3.04
45.19
4.8
2.9
349.23
352.77
umol/l
0.23
304
1411
44
39
11.97
42.61
2.4
1.7
568.42
687.94
e6/l
0.19
38
31
74
128
6.35
41.84
1.4
1.2
299.59
279.03
u/ml
0.17
46
78
71
118
6.58
41.75
1.7
1.5
151.81
162.91
au/ml
0.29
21
30
84
169
5.51
40.53
2.2
1.6
—
—
—
0
0
149
471
3.75
40.35
2.4
1.7
—
—
—
0
0
85
177
5.33
39.45
2.3
1.6
—
—
—
0
0
383
2107
2.81
39.24
6.9
3.5
38.32
33.79
u/l
1.03
373
2005
248
1086
2.99
39.18
3.3
1.9
—
—
—
0
0
201
795
3.14
37.85
2.9
1.8
—
—
—
0
0
469
2897
2.88
37.84
7.0
2.8
—
—
estimate
—
0
0
465
2877
2.84
37.07
6.8
3.1
280.77
128.51
ug/l
3.07
447
2688
98
243
4.53
36.86
2.0
2.1
6.79
7.36
g/l
2.21
92
224
98
243
4.53
36.86
2.0
2.1
4.10
4.23
g/l
0.58
92
224
234
1032
2.90
36.03
2.0
1.7
1132.56
1190.82
nmol/l
0.42
186
796
97
243
4.47
35.99
2.0
2.1
3.32
3.74
g/l
1.67
92
224
269
1283
2.78
35.62
2.1
1.4
2.48
2.46
g/l
0.03
195
819
367
2046
2.67
35.53
5.0
3.4
41.62
83.61
e6/l
0.61
305
1573
329
1749
2.66
34.94
4.9
3.3
0.33
0.44
e6/l
0.94
267
1280
88
210
4.65
34.67
2.1
2.2
10.36
10.60
g/l
0.18
81
190
280
1388
2.70
34.07
3.2
1.7
1.70
1.34
mg/l
1.17
232
1079
36
33
11.45
34.01
1.4
1.2
—
—
—
0
0
396
2329
2.61
33.78
5.8
4.0
106.26
105.27
e6/l
0.01
318
1655
72
154
5.10
32.28
1.7
1.5
—
—
—
0
0
155
574
3.18
32.17
5.4
2.6
37.65
42.50
u/l
0.24
139
478
36
36
10.49
32.06
1.5
1.5
—
—
—
0
0
36
36
10.49
32.06
1.5
1.5
—
—
—
0
0
185
766
2.92
31.48
12.9
9.3
11.64
12.18
kpa
0.67
177
743
185
766
2.92
31.48
13.0
9.3
5.02
5.11
kpa
0.54
178
741
618
4651
3.81
31.47
23.0
8.4
92.60
78.60
u/l
9.52
605
4415
278
1417
2.60
31.45
3.7
2.7
7.02
5.28
e6/l
1.03
267
1297
341
1914
2.52
31.43
4.9
3.3
2087.08
1380.36
ng/l
1.53
322
1649
183
755
2.93
31.33
13.0
9.4
0.99
0.90
mmol/l
0.10
155
626
183
756
2.92
31.24
3.2
1.9
—
—
—
0
0
88
228
4.27
31.12
2.1
2.1
3.05
3.04
g/l
0.02
82
209
35
36
10.18
30.55
3.0
3.6
86.49
105.22
%
1.62
35
36
56
100
6.00
30.52
1.6
1.3
10.12
4.14
u/ml
0.46
34
37
97
275
3.93
30.33
2.2
2.1
42.68
38.86
u/l
0.59
88
252
56
101
5.94
30.20
1.5
1.2
5.71
4.44
u/ml
0.20
35
41
48
75
6.80
29.79
2.4
2.5
34.68
55.69
iu/ml
—
6
10
162
646
2.96
29.32
9.1
3.5
1.61
1.96
mmol/l
0.67
141
553
58
112
5.56
29.10
2.3
1.8
—
—
—
0
0
160
637
2.96
29.02
3.4
4.6
21.70
28.46
ug/l
0.13
130
532
63
133
5.11
28.62
1.6
1.4
—
—
—
0
0
285
1530
2.46
28.20
6.7
2.4
—
—
—
0
0
81
213
4.17
28.02
2.2
2.4
0.41
0.94
g/l
0.80
75
187
79
204
4.24
27.99
1.6
1.3
—
—
—
0
0
75
189
4.32
27.43
1.7
2.3
0.01
0.03
g/l
0.29
70
168
74
185
4.35
27.34
2.2
1.6
—
—
—
0
0
51
99
5.48
25.40
1.2
1.2
—
—
—
0
0
517
3717
2.50
25.00
12.6
5.4
7.06
6.68
mmol/l
2.93
504
3513
587
4518
2.85
24.00
7.7
4.4
16.97
11.92
mm/h
8.05
568
4221
70
187
4.05
23.62
1.7
2.3
0.00
0.00
g/l
-0.00
64
158
412
2740
2.22
23.14
2.7
2.1
94.06
95.30
pmol/l
0.21
262
1466
44
83
5.59
22.58
1.7
1.5
—
—
—
0
0
43
80
5.66
22.39
1.8
1.5
—
—
—
0
0
408
2736
2.18
22.01
28.4
11.3
0.07
0.00
e9/l
1.58
345
2250
98
344
3.15
21.81
1.7
1.4
—
—
—
0
0
536
4035
2.40
21.44
7.1
4.7
35.33
1874.66
e6/l
—
6
68
55
134
4.37
20.93
1.8
1.5
—
—
—
0
0
76
236
3.49
20.58
2.4
2.9
—
—
—
0
0
30
42
7.42
20.49
2.1
2.5
45.77
42.59
%
0.30
16
23
78
251
3.37
19.97
3.3
3.7
50.52
5219.01
u/ml
0.73
67
218
47
106
4.68
19.68
1.8
1.5
—
—
—
0
0
194
1004
2.29
19.65
4.2
3.2
4.28
2.33
e6/l
1.39
99
485
110
438
2.79
19.45
4.4
3.2
256.04
213.63
ng/l
0.50
104
403
138
620
2.53
19.15
2.3
2.0
387.87
377.77
nmol/l
0.19
131
579
203
1090
2.21
18.68
4.1
3.0
1.31
1.07
e6/l
0.39
109
571
116
487
2.66
18.46
6.1
4.0
110.14
86.95
ng/l
1.23
108
427
100
389
2.83
18.44
2.5
1.7
—
—
—
0
0
77
259
3.22
18.32
2.2
2.2
9.61
7.74
iu/ml
0.19
20
65
67
207
3.47
18.25
1.3
1.3
—
—
—
0
0
95
362
2.88
18.19
7.4
2.4
0.65
0.63
%
0.28
95
362
216
1201
2.15
18.13
5.5
4.0
306.66
426.64
ng/l
0.40
178
932
38
78
5.09
17.76
2.4
2.0
—
—
—
0
0
36
71
5.29
17.59
2.4
2.1
—
—
—
0
0
96
375
2.81
17.54
4.8
3.8
1.85
1.70
mmol/l
0.16
68
290
450
3291
2.03
17.39
5.5
3.9
21.99
5.00
estimate
0.54
117
701
293
1849
2.01
17.29
2.3
1.7
19.29
20.26
nmol/l
0.50
268
1577
446
3257
2.02
17.24
5.5
3.9
0.00
0.00
estimate
0.50
115
686
38
81
4.90
17.00
4.7
2.6
32.13
33.43
pg
1.09
38
81
50
138
3.82
16.07
2.0
1.6
—
—
—
0
0
386
2727
1.93
15.91
3.4
2.5
74.43
76.36
nmol/l
0.66
358
2464
446
3314
1.95
15.70
5.6
3.9
0.01
0.01
estimate
0.10
110
654
26
42
6.39
15.57
4.5
1.5
—
—
—
0
0
52
157
3.50
14.65
1.3
1.2
—
—
—
0
0
25
22
11.74
13.88
1.0
1.0
—
—
—
0
0
32
71
4.68
13.66
1.2
1.2
—
—
—
0
0
56
187
3.17
13.45
1.5
1.4
265.42
283.56
ug/g
0.26
38
112
30
64
4.85
13.41
1.5
1.8
—
—
—
0
0
313
2153
1.82
13.21
5.7
3.5
2.33
2.35
mmol/l
1.36
293
1958
29
61
4.92
13.17
2.6
1.8
—
—
—
0
0
29
61
4.92
13.17
2.6
1.8
—
—
—
0
0
29
61
4.92
13.17
2.6
1.8
—
—
—
0
0
48
148
3.41
13.10
4.7
3.3
5.09
1.89
index
1.15
33
83
22
36
6.28
13.00
4.9
3.4
0.95
0.83
index
0.30
22
36
110
530
2.28
12.77
2.8
2.4
10.67
7.25
ug/l
0.78
91
481
509
4085
1.90
12.68
7.1
3.5
76.02
49.62
u/l
6.34
486
3877
22
38
5.94
12.33
1.5
1.2
—
—
—
0
0
42
126
3.48
11.96
2.4
3.8
642.78
454.48
u/ml
0.12
34
121
336
2412
1.76
11.87
6.8
3.9
58.07
70.90
ng/l
0.14
276
1760
34
94
3.75
10.92
1.2
1.4
—
—
—
0
0
21
22
9.80
10.81
3.2
2.0
6789.75
787.82
e6/l
0.44
16
17
201
1271
1.82
10.75
4.1
2.9
2.45
2.45
mmol/l
0.39
182
1147
45
152
3.10
10.61
1.6
1.5
—
—
—
0
0
38
116
3.41
10.54
1.5
1.2
—
—
—
0
0
38
116
3.41
10.54
1.5
1.2
—
—
—
0
0
136
768
1.96
10.29
2.1
1.8
1.67
1.50
%
1.39
116
677
20
38
5.39
10.16
1.1
1.0
—
—
—
0
0
119
644
2.02
10.15
5.7
3.3
—
—
—
0
0
45
157
2.99
10.04
3.6
2.3
118.91
129.65
g/l
1.22
32
125
21
44
4.89
9.59
1.9
1.4
—
—
—
0
0
18
18
10.23
9.56
3.1
1.6
30263.10
4673.90
e6/l
—
10
10
52
206
2.65
9.19
2.0
1.4
—
—
—
0
0
166
1039
1.78
8.99
1.3
1.3
18.67
11.73
u/ml
0.36
51
419
93
481
2.08
8.93
7.4
3.8
1.22
1.23
mmol/l
0.47
86
420
50
197
2.66
8.93
1.7
1.6
0.00
0.10
iu/ml
—
10
35
26
69
3.87
8.85
1.3
1.4
—
—
—
0
0
94
490
2.06
8.84
3.7
2.7
51.20
65.21
ml/min/173m2
2.54
49
203
213
1442
1.69
8.67
1.4
1.3
1.22
1.58
u/ml
0.33
51
419
27
75
3.70
8.63
1.5
1.4
1286.79
1795.02
e6/l
0.66
19
48
175
1134
1.72
8.33
1.5
1.3
82.36
33.06
iu/ml
0.89
54
345
36
124
3.01
8.24
4.2
3.1
0.76
0.87
nmol/l
0.80
25
103
257
1845
1.62
8.23
5.9
4.0
0.77
0.01
estimate
0.49
97
638
23
59
4.00
8.21
1.1
1.0
—
—
—
0
0
18
38
4.84
8.15
1.9
1.3
—
—
—
0
0
18
38
4.84
8.15
1.9
1.3
—
—
—
0
0
44
174
2.63
7.82
1.5
1.3
8.13
2.10
u/ml
—
8
29
44
174
2.63
7.82
1.4
1.2
1.40
2.52
u/ml
—
5
19
649
5934
2.29
7.75
49.3
16.2
28.74
24.21
mg/l
3.39
623
4899
70
346
2.14
7.56
3.8
3.9
4.19
4.55
pmol/l
2.67
64
309
12
9
13.54
7.40
1.5
1.2
—
—
—
0
0
133
823
1.76
7.37
3.1
2.5
256.40
128.11
ug/g
0.92
109
660
445
3691
1.56
7.29
3.8
3.0
—
—
—
0
0
27
89
3.12
6.68
1.1
1.1
—
—
—
0
0
653
6039
2.21
6.67
52.6
19.4
138.92
139.69
mmol/l
11.54
646
5932
52
240
2.26
6.65
5.0
4.5
25.12
24.91
mmol/l
0.25
47
227
322
2522
1.51
6.63
5.9
3.8
0.00
0.04
estimate
2.82
101
572
41
171
2.48
6.57
1.7
1.3
—
—
—
0
0
15
22
6.94
6.54
3.7
3.1
0.64
0.61
mmol/l
0.89
15
22
530
4636
1.59
6.36
5.2
4.3
14.96
14.82
pmol/l
0.64
502
4262
21
61
3.52
6.33
2.6
2.9
—
—
—
0
0
19
52
3.73
6.23
1.0
1.5
—
—
—
0
0
652
6051
2.13
6.19
54.0
19.5
3.98
3.98
mmol/l
0.05
645
5934
17
32
5.42
6.18
1.7
2.0
55.67
58.95
umol/l
—
6
19
16
39
4.18
6.11
1.8
1.3
—
—
—
0
0
10
8
12.66
6.09
1.1
1.6
—
—
—
0
0
183
1301
1.55
5.76
1.9
1.8
457.06
10724540.74
pmol/l
0.50
163
1091
13
19
6.95
5.75
2.3
3.7
6.77
5.99
ug/l
0.11
13
19
23
77
3.05
5.57
2.4
3.8
—
—
—
0
0
16
33
4.94
5.45
3.3
1.9
—
—
—
0
0
16
33
4.94
5.45
3.3
1.9
—
—
—
0
0
16
33
4.94
5.45
3.3
1.9
—
—
—
0
0
16
33
4.94
5.45
3.3
1.9
—
—
—
0
0
8
5
16.17
5.42
1.0
2.0
—
—
—
0
0
13
21
6.29
5.40
1.0
1.8
—
—
—
0
0
14
25
5.69
5.39
3.5
2.2
—
—
—
0
0
14
25
5.69
5.39
3.5
2.2
—
—
—
0
0
619
5697
1.75
5.32
40.3
15.5
78.98
81.07
ml/min/173m2
1.23
587
5294
14
26
5.47
5.24
3.5
2.1
—
—
—
0
0
33
140
2.42
5.14
1.2
1.3
—
—
—
0
0
21
70
3.06
5.14
1.1
1.2
—
—
—
0
0
237
1815
1.46
5.12
4.9
3.3
2.67
0.02
estimate
0.49
94
546
14
27
5.27
5.10
2.6
1.8
1.55
1.89
umol/l
0.72
14
22
10
12
8.43
5.07
2.1
1.3
—
—
—
0
0
45
222
2.10
4.93
5.4
3.4
1.47
1.35
mmol/l
0.41
45
217
15
33
4.62
4.89
1.1
1.2
99.73
74.04
u/l
0.94
15
27
20
67
3.04
4.86
1.5
1.5
51117.00
42821.41
e6/l
—
10
34
9
10
9.10
4.79
1.3
1.2
89.78
91.20
%
—
9
10
50
261
1.99
4.72
3.1
1.9
—
—
—
0
0
11
18
6.19
4.61
1.0
1.4
74.67
88.30
%
—
6
10
7
5
14.12
4.58
1.7
1.8
7503.86
21.60
u/l
—
7
5
56
308
1.89
4.55
2.1
1.6
0.43
0.31
mg/l
0.63
26
143
44
223
2.04
4.51
2.4
1.6
—
—
—
0
0
40
196
2.10
4.48
1.3
1.3
126.95
238.29
miu/ml
—
8
96
38
183
2.14
4.45
1.2
1.1
—
—
—
0
0
38
183
2.14
4.45
1.2
1.1
—
—
—
0
0
30
131
2.35
4.42
6.9
3.5
16.56
9.39
pmol/l
1.19
30
131
11
20
5.57
4.30
1.0
2.4
85.83
85.83
%
—
6
12
7
6
11.77
4.28
1.1
1.0
—
—
—
0
0
46
242
1.96
4.26
2.4
1.8
—
—
—
0
0
195
1486
1.43
4.20
5.8
4.0
1.02
1.02
kg/l
1.19
145
984
22
85
2.64
4.17
2.9
1.5
—
—
—
0
0
22
85
2.64
4.17
2.9
1.5
—
—
—
0
0
22
86
2.61
4.09
2.9
1.5
—
—
—
0
0
22
86
2.61
4.09
2.9
1.5
—
—
—
0
0
260
2095
1.38
4.03
4.9
4.3
24.37
8.84
mg/mmol
2.15
194
1352
7
7
10.08
4.01
13.1
6.4
5.39
6.03
mmol/l
—
7
7
13
32
4.12
3.92
1.9
1.3
—
—
—
0
0
270
2197
1.37
3.91
4.0
3.4
6.89
7.87
mmol/l
3.52
233
1867
22
88
2.55
3.91
2.9
1.5
—
—
—
0
0
22
88
2.55
3.91
2.9
1.5
—
—
—
0
0
21
83
2.58
3.83
3.3
2.9
15.50
5.44
umol/l
1.00
13
58
13
33
3.99
3.81
2.2
1.3
—
—
—
0
0
13
33
3.99
3.81
1.9
1.3
—
—
—
0
0
13
33
3.99
3.81
2.2
1.3
—
—
—
0
0
7
8
8.82
3.78
1.9
1.9
—
—
—
0
0
659
6273
1.86
3.75
55.5
21.1
88.51
79.11
umol/l
4.17
653
6201
13
34
3.88
3.70
7.8
3.6
0.77
0.94
%
0.26
13
34
8
12
6.73
3.68
1.9
2.2
—
—
—
0
0
15
51
2.98
3.59
1.4
1.1
—
—
—
0
0
32
158
2.07
3.56
2.1
1.5
21038.30
15951.84
e6/l
0.30
23
120
654
6229
1.76
3.46
29.5
12.2
31.24
26.54
u/l
1.43
646
6066
17
64
2.70
3.41
1.0
1.1
—
—
—
0
0
12
32
3.80
3.40
1.2
1.1
0.57
0.52
ratio
—
7
18
28
134
2.13
3.38
1.5
1.2
5.15
18.53
e6/l
0.95
20
98
15
53
2.87
3.37
1.0
1.1
—
—
—
0
0
15
53
2.87
3.37
1.3
1.1
—
—
—
0
0
8
14
5.77
3.35
1.0
1.3
—
—
—
0
0
591
5510
1.47
3.34
6.5
5.3
1.94
1.92
mu/l
0.07
561
5101
16
59
2.75
3.34
1.4
1.1
—
—
—
0
0
28
135
2.12
3.32
1.5
1.3
1878.22
1038.16
e6/l
0.17
23
105
35
627
0.53
3.32
1.5
2.0
3.58
3.54
ratio
0.08
29
504
15
54
2.82
3.27
1.4
1.1
—
—
—
0
0
15
54
2.82
3.27
1.4
1.1
—
—
—
0
0
22
453
0.47
3.18
1.3
1.8
3.05
3.46
mmol/l
1.07
15
338
20
85
2.39
3.18
4.3
2.9
1.21
1.20
mmol/l
0.27
20
85
13
44
2.99
3.15
1.0
1.2
—
—
—
0
0
595
5572
1.45
3.11
8.0
6.5
40.24
39.36
mmol/mol
1.09
549
5263
10
25
4.04
3.09
1.0
1.1
—
—
—
0
0
10
25
4.04
3.09
1.2
1.3
—
—
—
0
0
16
62
2.62
3.06
1.4
1.1
—
—
—
0
0
13
45
2.92
3.04
2.1
1.5
—
—
—
0
0
21
94
2.27
2.99
1.4
1.3
0.61
19.69
nmol/l
0.49
21
89
10
26
3.89
2.99
1.1
1.1
—
—
—
0
0
20
88
2.31
2.96
4.3
2.9
103.50
105.30
mmol/l
0.66
20
88
20
88
2.31
2.96
4.3
2.9
4.19
4.05
mmol/l
0.97
20
88
6
9
6.71
2.87
2.5
3.4
27.47
70.08
pmol/l
—
6
9
61
401
1.57
2.70
2.3
2.5
8.40
20.83
au/ml
—
5
35
10
30
3.37
2.61
1.1
1.0
1619.00
1475.83
miu/ml
—
10
30
18
81
2.25
2.56
1.3
1.2
0.18
0.18
nmol/l
0.07
13
61
10
32
3.16
2.44
1.5
1.0
—
—
—
0
0
48
306
1.61
2.43
1.5
1.3
—
—
—
0
0
5
8
6.28
2.37
1.2
1.1
—
—
—
0
0
5
8
6.28
2.37
1.4
1.1
—
—
—
0
0
603
5722
1.39
2.35
6.1
5.2
6.16
5.96
mmol/l
2.30
557
5278
6
13
4.65
2.27
2.0
1.2
—
—
—
0
0
31
180
1.76
2.22
1.4
1.3
—
—
—
0
0
8
24
3.36
2.18
1.1
1.2
116.60
213.11
iu/ml
—
8
24
8
24
3.36
2.18
1.0
1.1
—
—
—
0
0
7
19
3.71
2.15
1.6
1.2
11.19
8.84
ug/l
—
7
19
68
482
1.45
2.15
1.4
1.4
—
—
—
0
0
8
25
3.22
2.10
1.8
1.3
—
—
—
0
0
8
25
3.22
2.10
2.1
4.2
—
—
—
0
0
10
37
2.73
2.07
1.0
1.0
—
—
—
0
0
13
56
2.35
2.06
1.8
1.2
49190.00
364166.80
e6/l
—
6
40
10
38
2.65
2.01
1.0
1.1
—
—
—
0
0
5
11
4.57
1.94
7.6
10.7
10.06
10.68
%
—
5
11
8
28
2.88
1.86
1.3
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
40
2.52
1.67
1.1
1.2
—
—
—
0
0
5
14
3.59
1.62
7.6
9.9
4.82
4.74
kpa
—
5
14
33
215
1.56
1.59
2.0
2.2
115.06
4499.07
u/l
1.78
12
84
11
50
2.22
1.57
1.2
1.1
71.55
102.72
pmol/l
1.69
11
50
11
50
2.22
1.57
1.9
2.9
7.11
8.02
mmol/l
0.38
11
50
29
184
1.60
1.57
5.9
3.2
1.54
1.56
mmol/l
0.07
29
179
19
108
1.78
1.52
1.8
1.7
—
—
—
0
0
29
187
1.57
1.48
1.7
1.9
2.40
36.56
iu/l
—
10
73
6
22
2.74
1.43
1.5
1.1
—
—
—
0
0
580
5569
1.24
1.37
5.1
4.3
1.41
1.29
mmol/l
3.19
535
5163
659
6433
1.42
1.37
69.5
24.6
252.11
246.79
e9/l
0.53
652
6332
659
6434
1.41
1.36
69.1
24.5
91.14
91.11
fl
0.05
654
6374
659
6436
1.41
1.33
69.3
24.6
4.24
4.50
e12/l
21.14
650
6320
659
6436
1.41
1.33
71.6
25.2
37.94
40.48
%
24.87
654
6372
9
44
2.06
1.27
3.6
2.5
21.07
55.90
u/ml
—
9
44
6
25
2.41
1.24
1.8
1.5
—
—
—
0
0
55
419
1.34
1.22
1.2
1.2
129.80
150.94
u/ml
0.09
17
168
5
19
2.64
1.22
6.0
3.6
4.95
4.68
kpa
—
5
19
5
19
2.64
1.22
6.0
3.6
8.66
10.49
kpa
—
5
19
41
302
1.38
1.13
5.2
3.7
1.02
1.02
ratio
0.55
35
285
7
31
2.27
1.10
2.0
1.4
—
—
—
0
0
23
152
1.53
1.10
6.2
3.3
7.55
7.43
mmol/l
0.08
23
147
15
89
1.70
1.08
1.1
1.1
—
1.89
—
0
16
7
32
2.20
1.08
1.1
2.1
—
33.58
—
0
5
5
22
2.28
1.03
1.4
1.5
42.20
41.10
g/l
—
5
22
610
5934
1.22
0.98
6.2
5.8
2.40
2.68
mmol/l
13.32
570
5554
12
69
1.75
0.97
1.6
1.4
23.72
25.01
u/l
0.04
12
58
126
1094
1.19
0.95
1.6
1.5
—
—
—
0
0
6
29
2.08
0.89
3.3
2.9
229.67
201.52
u/l
—
6
29
16
103
1.57
0.88
1.3
1.5
0.18
0.36
nmol/l
1.92
11
81
6
30
2.01
0.87
2.2
2.3
—
—
—
0
0
34
260
1.32
0.79
1.4
1.4
31.94
21.53
iu/l
0.87
28
222
9
53
1.71
0.75
2.1
1.2
—
—
—
0
0
9
54
1.68
0.74
2.1
1.2
—
—
—
0
0
599
5851
1.16
0.72
5.6
5.2
4.19
4.58
mmol/l
17.51
563
5492
7
41
1.71
0.70
1.1
1.6
—
—
—
0
0
16
111
1.45
0.66
2.2
1.8
—
—
—
0
0
7
44
1.60
0.65
1.3
1.8
—
—
—
0
0
14
200
0.69
0.63
1.1
1.1
1.40
1.51
g/l
1.05
14
200
80
695
1.17
0.63
13.7
7.3
—
—
—
0
0
33
264
1.26
0.59
1.6
1.6
1074.55
974.58
mu/l
0.26
27
220
594
5820
1.14
0.57
5.6
5.0
1.26
1.44
mmol/l
21.77
550
5439
27
212
1.28
0.56
2.0
1.8
—
—
—
0
0
36
301
1.21
0.46
2.0
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
40.68
—
0
19
5
36
1.39
0.38
1.6
1.8
118.80
82.73
ng/l
—
5
36
9
69
1.31
0.37
1.0
1.2
—
—
—
0
0
14
180
0.77
0.37
1.6
1.6
—
—
—
0
0
9
70
1.29
0.36
1.9
1.5
—
—
—
0
0
42
366
1.16
0.36
2.2
1.8
—
—
—
0
0
168
1779
0.93
0.36
4.5
4.5
21.87
21.59
%
0.08
85
862
6
46
1.31
0.33
1.8
1.5
73.83
77.78
umol/l
—
6
46
35
305
1.16
0.31
1.1
1.0
—
—
—
0
0
13
164
0.79
0.31
1.2
1.4
—
—
—
0
0
17
143
1.19
0.23
1.4
1.6
1.30
1.14
ratio
—
10
93
17
143
1.19
0.23
1.4
1.6
0.92
0.95
ratio
—
10
93
17
143
1.19
0.23
1.4
1.6
1.52
1.14
ratio
—
10
93
15
179
0.83
0.23
2.1
2.0
163.60
217.72
pmol/l
0.95
15
169
7
91
0.77
0.22
8.0
3.1
23.00
18.88
u/ml
—
7
91
0
12
0.00
0.21
0.0
1.3
—
1.17
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
6
49
1.23
0.20
1.2
1.1
—
15.36
—
0
23
79
838
0.94
0.20
1.4
1.5
—
—
—
0
0
19
165
1.16
0.19
2.4
2.4
83.42
87.95
ug/min
0.04
12
98
73
688
1.07
0.18
2.2
2.0
—
—
—
0
0
67
635
1.06
0.15
2.0
1.9
—
—
—
0
0
11
94
1.17
0.13
2.0
1.6
51.74
48.73
ug/l
0.08
11
94
78
747
1.05
0.13
5.3
4.8
32.34
31.79
%
0.15
56
506
16
142
1.13
0.12
1.4
1.6
—
—
—
0
0
217
2212
0.97
0.11
5.4
5.5
3.58
2.77
ug/l
0.32
195
2004
10
86
1.17
0.11
1.2
1.1
—
—
—
0
0
128
1313
0.97
0.10
3.0
3.2
0.77
0.77
ug/l
0.04
85
854
254
2559
0.99
0.04
2.0
1.9
1.69
1.35
mmol/l
2.83
225
2179
18
187
0.96
0.01
1.6
1.5
—
—
—
0
0
23
224
1.03
0.00
1.7
2.0
41.70
39.55
nmol/l
0.15
23
215
12
115
1.04
0.00
1.2
1.1
0.18
1.07
u/ml
—
6
62
13
125
1.04
0.00
1.9
1.7
—
—
—
0
0
21
208
1.01
0.00
2.1
1.2
0.82
0.90
g/l
0.75
21
208
0
7
0.00
0.00
0.0
1.0
—
89.86
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
10.67
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_SPLEENDISEASE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENDISEASE | 3.971 [3.07, 5.14] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 415 out of 1386 females with D3_SPLEENDISEASE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENDISEASE | 3.698 [2.92, 4.68] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 499 out of 1462 males with D3_SPLEENDISEASE died.
Mortality risk
Mortality risk for people of age
years, who have D3_SPLEENDISEASE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.481% | 0.759% |
| 5 | 2.249% | 4.089% |
| 10 | 5.579% | 10.28% |
| 15 | 10.302% | 19.424% |
| 20 | 17.274% | 31.076% |
Relationships between endpoints
↥Index endpoint: D3_SPLEENDISEASE – Diseases of spleen
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data