splenic disease: A disease involving the spleen.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
184 |
4. Check minimum number of eventsNone |
184 |
5. Include endpointsNone |
184 |
6. Filter based on genotype QC (FinnGen only) |
151 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified diseases of spleen
based on the number of shared cases.
Similar with more cases:
- Diseases of spleen
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 905 | 489 | 409 |
| Only index persons | 758 | 427 | 331 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.59 | 60.01 | 56.88 |
| Only index persons | 56.10 | 56.89 | 55.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 151 | 81 | 70 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 58.08 | 56.66 | 59.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 161
- Matched controls
- 1610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.9
ICD-10 Finland
Disease of spleen, unspecified
+∞
103.7
88
*
D73.8
ICD-10 Finland
Other diseases of spleen
+∞
70.0
62
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
161.0
26.5
27
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.2
18.0
46
116
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
201.2
17.9
18
*
XW000
NOMESCO Finland
Bone marrow biopsy
11.3
13.8
26
27
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
25.3
10.4
14
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.0
10.4
69
320
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
106.0
9.5
10
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.8
8.9
31
96
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
8.8
51
217
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.0
8.7
27
77
J01MA12
ATC
levofloxacin; systemic
3.1
8.6
45
180
D64.9
ICD-10 Finland
Anaemia, unspecified
3.6
8.5
31
99
M04AA01
ATC
allopurinol; systemic
3.5
8.5
33
110
D73.5
ICD-10 Finland
Infarction of spleen
+∞
8.4
8
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.6
7.4
27
86
JN4AD
NOMESCO Finland
Body CT examination
3.4
7.4
29
97
UJF32
NOMESCO Finland
Coloscopy
2.6
7.3
56
273
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.4
7.2
18
31
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
8.4
6.8
14
18
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
23.7
6.7
9
*
B01AB05
ATC
enoxaparin; parenteral
2.5
6.7
60
313
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.9
6.6
20
56
X59
ICD-10 Finland
Exposure to unspecified factor
2.7
6.3
39
169
2895A
ICD-9 Finland
Other diseases of blood and blood-forming organs, Other diseases of spleen
+∞
6.3
6
*
D73.1
ICD-10 Finland
Hypersplenism
+∞
6.3
6
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
9.2
6.2
12
14
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
6.2
73
427
R50.9
ICD-10 Finland
Fever, unspecified
2.7
6.0
36
153
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
116
5.31
18.88
2.6
2.5
10.65
10.90
g/l
0.14
42
104
88
465
2.97
10.50
5.3
2.6
81.27
63.29
u/l
0.27
82
428
104
631
2.83
9.12
5.0
2.7
—
—
estimate
—
0
0
69
353
2.67
8.30
4.0
2.9
360.68
342.27
umol/l
0.66
62
311
50
217
2.89
8.25
1.9
1.7
1149.90
1165.53
nmol/l
0.04
42
167
46
196
2.89
7.81
12.2
5.7
0.99
1.01
mmol/l
0.23
41
179
34
122
3.27
7.75
2.4
2.6
0.22
0.21
g/l
0.12
34
114
18
41
4.82
7.64
3.0
3.9
1.31
2.70
ratio
—
9
21
117
802
2.68
7.30
12.8
10.2
4.16
4.14
e9/l
0.02
106
712
104
678
2.51
7.16
16.3
7.3
1.21
1.21
mmol/l
0.31
81
590
94
611
2.29
6.17
13.7
6.4
1.21
1.22
mmol/l
0.64
85
565
63
349
2.32
6.02
3.0
2.1
4.00
2.82
mg/l
2.28
55
306
57
313
2.27
5.48
1.5
1.8
1.45
0.92
mg/l
0.63
45
252
80
506
2.15
5.39
3.9
3.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
35
4.96
5.35
4.5
2.2
0.32
0.35
iu/ml
0.10
11
16
34
150
2.61
5.26
10.6
8.3
0.60
1.17
mmol/l
0.46
29
126
34
153
2.55
5.04
2.2
4.5
4.38
5.90
ug/l
0.31
26
126
133
1057
2.49
4.73
15.1
8.3
82.32
77.06
u/l
0.84
126
1002
12
24
5.31
4.41
1.5
1.3
409.40
142.36
u/ml
—
5
11
15
39
4.13
4.33
1.1
2.0
—
—
—
0
0
54
324
2.00
3.95
3.2
2.2
—
—
—
0
0
24
107
2.46
3.60
2.0
1.5
—
—
—
0
0
7
9
8.07
3.59
1.6
1.3
—
—
—
0
0
6
6
10.32
3.52
1.8
1.0
736.00
510.67
u/ml
—
6
6
121
971
1.99
3.51
4.5
3.3
67.79
47.69
u/l
0.92
111
927
84
605
1.81
3.39
2.5
2.1
88.60
97.46
pmol/l
1.18
55
318
8
14
5.95
3.38
1.5
1.1
—
—
—
0
0
81
578
1.81
3.37
5.2
3.6
0.00
0.01
estimate
0.50
30
140
62
408
1.85
3.36
4.0
3.4
0.26
0.42
e6/l
0.73
51
291
14
49
3.03
3.28
1.8
1.7
—
—
—
0
0
11
29
3.99
3.25
4.3
1.3
—
—
—
0
0
14
50
2.97
3.17
1.8
1.7
—
—
—
0
0
64
436
1.78
3.04
4.5
3.2
0.00
0.02
estimate
0.75
26
132
126
1051
1.91
2.92
7.3
4.6
15.98
11.60
mm/h
1.79
121
982
12
38
3.33
2.92
1.3
1.7
—
—
—
0
0
6
9
6.87
2.89
2.7
1.7
5.97
4.13
mg/l
—
6
9
35
201
1.95
2.82
10.1
7.5
103.80
104.31
mmol/l
0.25
35
201
5
165
0.28
2.75
1.2
2.1
3.70
3.50
ratio
—
5
133
7
15
4.83
2.62
1.0
1.1
—
—
—
0
0
17
75
2.42
2.61
6.3
2.4
0.68
0.64
%
0.29
17
75
96
754
1.68
2.59
5.4
3.7
0.00
0.00
estimate
-0.00
31
163
12
45
2.80
2.51
1.3
1.6
—
—
—
0
0
39
241
1.82
2.51
2.7
1.9
—
—
—
0
0
0
64
0.00
2.49
0.0
1.8
—
5.92
—
0
46
17
77
2.35
2.47
6.0
2.5
1.17
1.29
%
0.20
17
77
43
275
1.77
2.47
1.7
1.8
432.82
449.48
pmol/l
0.16
38
239
5
8
6.40
2.39
1.0
2.3
—
—
—
0
0
5
8
6.40
2.39
1.0
2.3
—
—
—
0
0
7
17
4.25
2.38
3.9
2.8
1.21
1.20
mmol/l
—
7
17
7
17
4.25
2.38
3.9
2.8
100.71
106.53
mmol/l
—
7
17
58
409
1.65
2.32
5.1
3.9
0.00
0.00
estimate
-0.00
25
145
26
144
1.96
2.32
5.4
3.1
—
—
—
0
0
39
247
1.76
2.30
1.3
1.3
1.02
5.80
u/ml
—
9
97
58
412
1.64
2.25
2.0
1.8
21.22
21.89
nmol/l
0.09
48
347
41
267
1.72
2.19
1.4
1.3
114.73
33.47
iu/ml
—
8
90
95
765
1.59
2.16
5.5
3.7
0.00
9.90
estimate
0.50
31
164
8
25
3.31
2.12
1.3
1.7
—
—
—
0
0
51
356
1.63
2.10
1.3
1.3
0.82
1.69
u/ml
0.83
12
102
12
50
2.51
2.08
1.2
1.3
—
—
—
0
0
9
33
2.83
1.96
1.2
1.6
—
—
—
0
0
95
777
1.54
1.93
5.5
3.8
0.03
0.00
estimate
0.49
29
149
147
1343
2.09
1.90
32.4
15.6
25.25
22.93
mg/l
0.41
140
1112
8
28
2.95
1.89
6.3
3.4
17.56
11.73
pmol/l
—
8
28
14
66
2.23
1.88
1.9
1.2
—
—
—
0
0
71
557
1.49
1.69
6.0
3.8
33.18
41.34
ng/l
0.29
56
394
62
476
1.49
1.63
7.3
3.2
2.33
2.35
mmol/l
0.47
56
436
10
43
2.41
1.62
1.2
1.3
—
—
—
0
0
6
20
3.07
1.59
2.0
2.2
—
—
—
0
0
5
15
3.40
1.53
1.0
1.3
—
—
—
0
0
31
208
1.61
1.47
1.5
1.5
—
—
—
0
0
9
39
2.38
1.45
1.1
1.6
—
—
—
0
0
5
16
3.19
1.45
1.0
1.3
—
—
—
0
0
6
22
2.79
1.45
2.0
2.1
—
—
—
0
0
28
184
1.63
1.44
2.5
1.7
—
—
—
0
0
76
623
1.42
1.36
3.3
2.6
71.57
76.69
nmol/l
0.89
68
573
118
1048
1.47
1.35
6.0
4.3
14.76
14.74
pmol/l
0.03
111
973
11
55
2.07
1.30
2.3
2.7
—
—
—
0
0
5
18
2.83
1.29
2.4
1.8
—
—
—
0
0
5
18
2.83
1.29
2.4
1.8
—
—
—
0
0
5
18
2.83
1.29
2.4
1.8
—
—
—
0
0
8
35
2.35
1.29
1.9
1.9
—
—
—
0
0
8
36
2.28
1.26
1.0
1.3
—
—
—
0
0
10
49
2.11
1.25
1.5
1.2
—
—
—
0
0
43
323
1.45
1.22
5.3
3.7
1.02
1.02
kg/l
1.45
34
216
6
26
2.36
1.20
1.0
1.2
1.46
1.37
g/l
—
6
21
139
1291
1.56
1.13
26.2
15.5
78.24
81.34
ml/min/173m2
0.76
127
1205
17
105
1.69
1.11
3.0
3.1
50.58
63.17
ml/min/173m2
0.76
12
42
5
21
2.42
1.10
1.2
1.2
—
—
—
0
0
5
21
2.42
1.10
1.2
1.2
—
—
—
0
0
5
21
2.42
1.10
1.2
1.2
—
—
—
0
0
5
21
2.42
1.10
1.2
1.2
—
—
—
0
0
25
173
1.53
1.05
2.6
1.8
—
—
—
0
0
5
22
2.31
1.04
1.2
1.2
—
—
—
0
0
5
22
2.31
1.04
1.2
1.2
—
—
—
0
0
37
280
1.42
1.01
5.0
3.6
103.38
226.91
ng/l
0.49
27
215
10
54
1.91
0.99
2.5
2.0
—
—
—
0
0
9
50
1.85
0.98
1.9
1.8
—
—
—
0
0
32
239
1.42
0.94
3.2
3.1
1.39
0.85
e6/l
0.43
18
121
8
42
1.95
0.90
2.0
3.2
0.00
0.00
g/l
—
8
42
6
31
1.97
0.85
1.0
1.2
—
—
—
0
0
10
59
1.74
0.77
2.1
3.5
21.00
601.00
u/ml
—
5
51
29
222
1.37
0.75
3.3
3.3
5.69
2.05
e6/l
0.87
14
105
5
25
2.03
0.73
1.2
1.5
—
—
—
0
0
7
40
1.78
0.72
1.3
1.2
—
—
—
0
0
5
26
1.95
0.71
1.2
1.7
—
—
—
0
0
7
41
1.74
0.71
1.3
1.2
—
—
—
0
0
10
61
1.68
0.70
1.5
1.7
—
—
—
0
0
5
28
1.81
0.66
1.6
1.2
—
—
—
0
0
11
71
1.59
0.64
2.0
1.8
—
—
—
0
0
0
20
0.00
0.61
0.0
1.7
—
—
—
0
0
151
1463
1.52
0.56
47.9
23.8
4.31
4.51
e12/l
3.75
146
1437
5
32
1.58
0.42
1.8
1.3
14744.80
3754.91
e6/l
—
5
23
16
123
1.33
0.42
3.9
2.8
0.15
0.17
e6/l
0.07
16
115
17
132
1.32
0.42
13.9
7.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
6.62
—
0
9
5
35
1.44
0.39
1.2
1.3
2.00
31.64
e6/l
—
5
25
5
36
1.40
0.38
1.2
1.6
—
—
—
0
0
5
36
1.40
0.38
1.2
1.4
2.60
202.41
e6/l
—
5
27
9
69
1.32
0.38
2.4
1.3
—
—
—
0
0
24
285
0.81
0.36
3.9
3.1
0.72
0.87
ug/l
0.42
17
186
130
1256
1.18
0.32
7.3
5.3
1.85
1.96
mu/l
0.52
120
1158
133
1289
1.18
0.30
7.0
6.4
40.70
39.20
mmol/mol
0.72
120
1223
10
76
1.34
0.29
1.2
1.5
—
—
—
0
0
50
456
1.14
0.28
6.2
4.0
24.62
9.13
mg/mmol
1.19
38
290
91
863
1.13
0.27
3.1
3.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
7.79
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
187.39
—
0
14
6
50
1.21
0.20
1.8
1.7
—
—
—
0
0
14
160
0.86
0.15
2.4
1.8
—
—
—
0
0
11
127
0.86
0.13
1.6
1.4
—
—
—
0
0
29
269
1.10
0.12
1.3
1.6
—
—
—
0
0
35
372
0.92
0.11
4.7
4.4
19.99
22.31
%
0.50
21
177
5
47
1.07
0.09
1.0
1.3
—
—
—
0
0
133
1312
1.08
0.09
5.8
4.9
6.08
5.94
mmol/l
0.54
122
1220
133
1341
0.95
0.04
5.6
5.1
1.31
1.45
mmol/l
3.20
121
1251
134
1350
0.96
0.03
5.5
5.1
4.38
4.63
mmol/l
2.01
124
1268
58
588
0.98
0.01
2.2
2.0
1.79
1.39
mmol/l
0.66
49
493
129
1286
1.02
0.00
4.9
4.3
1.42
1.29
mmol/l
0.96
116
1194
47
471
1.00
0.00
4.8
5.2
2.54
2.82
ug/l
0.13
40
428
14
145
0.96
0.00
2.3
1.8
—
—
—
0
0
136
1362
0.99
0.00
6.1
5.8
2.55
2.72
mmol/l
1.42
125
1278
0
8
0.00
-0.00
0.0
1.0
—
26.73
—
0
8
0
5
0.00
-0.00
0.0
2.2
—
1.18
—
0
5
8
83
0.96
-0.00
6.6
3.0
23.25
24.75
mmol/l
—
8
83
0
6
0.00
-0.00
0.0
1.0
—
174.17
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
8.57
—
0
7
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
74
0.94
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_SPLEENNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENNAS | 3.05 [2.07, 4.49] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 308 females with D3_SPLEENNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENNAS | 2.705 [1.59, 4.59] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 259 males with D3_SPLEENNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_SPLEENNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.325% | 0.504% |
| 5 | 1.613% | 2.996% |
| 10 | 4.027% | 8.117% |
| 15 | 7.92% | 15.309% |
| 20 | 13.948% | 25.008% |
Relationships between endpoints
↥Index endpoint: D3_SPLEENNAS – Other and unspecified diseases of spleen
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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