splenic infarction: Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
252 |
4. Check minimum number of eventsNone |
252 |
5. Include endpointsNone |
252 |
6. Filter based on genotype QC (FinnGen only) |
228 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D73
- Name in latin
- Infarctus lienis
Similar endpoints
↥List of similar endpoints to
Infarction of spleen
based on the number of shared cases.
Similar with more cases:
- Diseases of spleen
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1148 | 520 | 622 |
| Only index persons | 1015 | 470 | 545 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 67.93 | 70.81 | 65.47 |
| Only index persons | 67.43 | 70.42 | 64.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 228 | 103 | 125 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | 69.07 | 68.52 | 69.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 237
- Matched controls
- 2370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.5
ICD-10 Finland
Infarction of spleen
+∞
307.7
236
*
JN3AD
NOMESCO Finland
Abdominal CT examination
8.0
52.9
98
192
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.8
43.7
75
133
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
9.9
35.5
45
55
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.9
34.0
78
181
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.9
32.4
73
166
R10.1
ICD-10 Finland
Pain localized to upper abdomen
4.8
28.6
90
269
N28.0
ICD-10 Finland
Ischaemia and infarction of kidney
114.0
28.4
30
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.1
27.1
55
112
B01AB05
ATC
enoxaparin; parenteral
4.0
25.1
131
557
C03CA01
ATC
furosemide; systemic
4.0
25.0
132
565
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.3
23.1
174
932
B01AA03
ATC
warfarin; systemic
4.1
22.9
90
311
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.8
22.9
130
576
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.6
22.5
40
71
JN4AD
NOMESCO Finland
Body CT examination
4.5
21.4
64
180
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
21.0
90
327
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.6
19.4
89
336
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.5
19.3
42
90
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
19.2
81
289
L01XX05
ATC
hydroxycarbamide; oral
23.2
19.1
27
13
TPH07
NOMESCO Finland
Cathetrisation of artery
4.3
18.9
58
165
WW500
NOMESCO Finland
Blood transfusion
6.8
18.6
31
51
I50.9
ICD-10 Finland
Heart failure, unspecified
3.8
18.5
72
243
XW000
NOMESCO Finland
Bone marrow biopsy
7.0
18.0
29
46
M04AA01
ATC
allopurinol; systemic
3.7
16.6
64
213
N02AA05
ATC
oxycodone; systemic
3.3
16.6
87
353
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.0
15.4
106
499
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.0
15.1
101
468
B01AB10
ATC
tinzaparin; parenteral
3.9
15.0
51
155
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.8
14.7
52
162
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
13.8
84
366
AA1AD
NOMESCO Finland
CT of head and brain
2.7
13.0
110
568
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
137.0
12.6
13
*
D45
ICD-10 Finland
Polycythaemia vera
19.3
12.3
18
10
C07AB07
ATC
bisoprolol; oral
2.7
12.1
157
991
WX892
NOMESCO Finland
Monitored bed care
3.9
12.0
39
114
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.2
11.9
34
90
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.1
11.9
36
100
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.4
11.6
31
78
I50.0
ICD-10 Finland
Congestive heart failure
3.7
11.1
38
115
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
10.3
10.5
20
21
C03DA01
ATC
spironolactone; oral
3.1
10.4
51
194
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.7
10.3
25
58
A10AE04
ATC
insulin glargine; parenteral
3.3
10.1
43
150
JAH00
NOMESCO Finland
Laparotomy
5.5
10.0
20
39
H02AB06
ATC
prednisolone; systemic
2.4
9.9
139
878
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.7
9.8
24
56
WX402
NOMESCO Finland
General anaesthesia
2.6
9.8
72
338
A41.9
ICD-10 Finland
Sepsis, unspecified
5.4
9.8
20
40
D64.9
ICD-10 Finland
Anaemia, unspecified
3.1
9.7
45
165
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.8
9.5
22
49
R10.0
ICD-10 Finland
Acute abdomen
9.3
9.5
19
22
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
9.4
55
229
D75.2
ICD-10 Finland
Essential thrombocytosis
+∞
9.4
9
*
JN4BD
NOMESCO Finland
Extensive body CT
3.1
9.3
43
157
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
9.1
86
452
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.9
9.1
49
195
K78
ICPC
Atrial fibrillation/flutter
3.4
9.1
35
114
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.8
9.0
21
47
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
8.6
45
176
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.1
8.6
25
67
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.5
8.5
66
317
A03FA01
ATC
metoclopramide; systemic, rectal
2.5
8.4
70
346
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.4
8.4
76
391
Z3231
NOMESCO Finland
Registered nurse
2.3
8.3
82
438
K86.3
ICD-10 Finland
Pseudocyst of pancreas
34.6
8.1
10
*
R11
ICD-10 Finland
Nausea and vomiting
3.1
8.1
37
134
SPAT1262
SPAT
Handing over of treatment supplies
2.5
7.9
58
270
WX872
NOMESCO Finland
Intensive care
4.0
7.8
23
62
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
7.8
76
402
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
46.5
7.8
9
*
N02AX02
ATC
tramadol; systemic, rectal
2.2
7.7
121
774
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
19.1
7.7
11
6
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
7.6
57
267
A02BC02
ATC
pantoprazole; systemic
2.4
7.6
180
1352
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
8.1
7.5
16
21
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.2
7.5
32
111
D70.89
ICD-10 Finland
Neutropenic splenomegaly
82.6
7.5
8
*
PD5AD
NOMESCO Finland
CT of aorta
7.2
7.4
17
25
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
7.4
38
147
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
7.4
61
299
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.6
7.3
25
75
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.7
7.3
17
38
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
16.4
7.3
11
7
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
4.3
7.2
19
47
Z51.5
ICD-10 Finland
Palliative care
2.8
7.2
39
155
JMA10
NOMESCO Finland
Transabdominal total splenectomy
20.8
7.2
10
5
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.3
7.2
28
92
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
9.2
7.2
14
16
A06AD11
ATC
lactulose; oral
2.5
7.1
49
220
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.9
7.1
35
132
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.8
7.1
19
35
I50.1
ICD-10 Finland
Left ventricular failure
3.9
7.1
21
57
R50.9
ICD-10 Finland
Fever, unspecified
2.5
7.0
51
235
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.0
7.0
32
116
ZXD05
NOMESCO Finland
Urgent procedure
2.2
6.9
83
475
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
17.3
6.8
10
6
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
41.3
6.8
8
*
R4110
NOMESCO Finland
Physiotherapy
2.1
6.8
83
478
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.2
6.7
77
431
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
23.3
6.7
9
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.4
6.7
17
41
K55.0
ICD-10 Finland
Acute vascular disorders of intestine
12.7
6.6
11
9
SPAT1255
SPAT
Intravenous administration of medicine
3.2
6.6
27
91
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.8
6.6
36
144
N07BB01
ATC
disulfiram; oral
3.8
6.5
20
56
374
Kela drug reimbursment
Ruxolitinib
71.7
6.5
7
*
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
71.7
6.5
7
*
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
+∞
6.3
6
*
L01XX35
ATC
anagrelide; oral
+∞
6.3
6
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.3
6.3
58
297
J01MA12
ATC
levofloxacin; systemic
2.3
6.3
58
297
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.0
6.2
28
100
M10.9
ICD-10 Finland
Gout, unspecified
3.0
6.2
29
106
KH1AD
NOMESCO Finland
CT of urinary organs
5.5
6.1
17
33
207
Kela drug reimbursment
Chronic arrhythmias
2.3
6.1
54
271
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
10.4
6.1
11
11
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
10.4
6.1
11
11
ZXE00
NOMESCO Finland
One hour or less
2.0
6.0
101
646
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
7.6
6.0
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
68
71
13.03
61.42
4.5
2.0
0.31
0.31
iu/ml
0.00
54
30
105
298
5.53
36.72
7.1
5.6
1.08
1.05
mmol/l
0.40
98
280
31
25
14.12
32.14
1.2
1.1
—
—
—
0
0
35
35
11.56
31.71
1.6
1.3
6.18
1.27
u/ml
0.78
22
11
36
39
10.70
30.84
1.4
1.2
66.21
21.41
u/l
1.20
29
33
35
37
10.93
30.49
1.6
1.2
7.24
4.80
u/ml
0.24
21
15
158
718
4.60
28.54
6.0
2.6
56.59
68.29
u/l
0.65
152
674
199
1082
6.23
28.30
36.3
14.0
1.51
1.27
inr
5.65
180
900
32
37
9.84
26.02
8.6
5.3
209.38
290.60
iu/ml
—
8
5
31
36
9.76
25.10
1.3
1.1
—
—
—
0
0
134
581
4.01
24.88
3.3
2.2
4.17
3.06
mg/l
2.36
127
505
61
150
5.13
24.25
2.1
1.6
—
—
—
0
0
193
1125
4.85
22.40
15.3
7.5
1.20
1.21
mmol/l
1.27
177
984
200
1210
5.18
21.73
20.4
9.8
5.34
4.19
e9/l
3.04
187
1065
86
306
3.84
20.70
2.9
1.8
—
—
—
0
0
101
404
3.61
20.31
3.3
1.9
—
—
—
0
0
174
989
3.86
19.81
7.3
2.9
—
—
estimate
—
0
0
48
122
4.68
18.03
2.0
1.8
1.38
1.54
g/l
0.56
42
110
147
781
3.32
18.02
4.8
3.3
2081.53
1356.68
ng/l
1.46
138
658
36
73
5.64
17.52
1.5
1.2
—
—
—
0
0
79
293
3.54
17.49
14.9
7.6
1.44
1.02
mmol/l
0.41
67
252
60
192
3.85
16.48
2.6
2.6
12.20
9.12
ug/l
0.37
50
172
108
499
3.14
16.47
2.6
1.8
2.15
1.61
mg/l
0.87
91
404
142
766
3.13
16.46
5.5
3.4
21.30
137.38
e6/l
0.77
123
592
39
90
4.99
16.39
1.2
3.9
42.61
51.62
mg/l
0.16
31
77
39
90
4.99
16.39
1.2
3.9
49.66
124.04
mg/l
0.56
31
76
37
82
5.16
16.29
1.2
3.5
1.32
3.70
ratio
1.21
21
44
162
946
3.25
16.26
5.0
3.0
262.55
140.48
ug/l
2.99
155
873
77
293
3.41
16.23
3.1
1.9
—
—
—
0
0
112
533
3.09
16.15
3.7
2.7
7.38
4.46
e6/l
0.93
107
491
70
252
3.52
16.09
6.4
3.5
1.78
1.94
mmol/l
0.15
61
214
49
138
4.22
16.04
2.6
1.7
—
—
—
0
0
23
34
7.38
15.15
1.3
1.1
—
—
—
0
0
125
656
2.92
14.75
5.2
3.3
0.34
0.41
e6/l
0.31
108
480
45
127
4.14
14.63
1.6
1.3
—
—
—
0
0
107
519
2.94
14.59
6.6
2.5
—
—
—
0
0
22
33
7.25
14.28
1.7
1.3
—
—
—
0
0
22
33
7.25
14.28
1.8
1.3
161.86
176.53
au/ml
—
7
12
58
199
3.53
14.21
6.3
2.7
35.18
32.88
u/l
0.14
51
161
29
59
5.46
13.98
1.8
1.5
—
—
—
0
0
113
576
2.84
13.88
5.5
3.0
361.80
358.86
umol/l
0.11
106
502
48
150
3.76
13.48
5.1
2.8
1.48
1.26
%
0.59
48
150
31
70
4.94
13.28
2.0
1.5
—
—
—
0
0
30
67
4.98
13.01
1.9
1.5
—
—
—
0
0
29
64
5.02
12.75
1.7
1.5
—
—
—
0
0
92
445
2.74
12.19
6.5
4.1
387.19
333.15
ng/l
0.12
82
365
25
51
5.36
11.98
1.5
1.5
—
—
—
0
0
45
147
3.54
11.76
5.2
2.8
0.59
0.63
%
0.50
45
147
84
402
2.69
11.22
2.0
1.8
1177.86
1246.34
nmol/l
0.30
69
303
27
63
4.71
11.09
2.2
1.7
—
—
—
0
0
124
725
2.49
10.78
4.9
3.5
2.33
2.35
mmol/l
1.05
117
656
29
74
4.33
10.66
1.9
1.6
10.84
5.99
iu/ml
—
10
19
61
253
2.90
10.65
4.0
4.5
10.14
23.50
ug/l
0.36
52
215
25
58
4.70
10.32
1.5
1.4
—
—
—
0
0
24
54
4.83
10.27
5.1
3.3
6.44
1.64
index
0.84
16
28
22
46
5.17
10.23
2.0
1.6
—
—
—
0
0
167
1178
2.41
8.78
6.1
4.4
0.00
6.06
estimate
0.50
41
268
43
163
3.00
8.71
13.9
6.2
24.14
24.56
mmol/l
0.20
43
156
165
1163
2.38
8.61
6.2
4.4
0.00
0.00
estimate
-0.00
41
265
202
1569
2.95
8.47
7.2
4.5
19.42
12.87
mm/h
4.92
195
1445
167
1189
2.37
8.43
6.2
4.4
0.00
0.01
estimate
0.50
41
248
21
50
4.51
8.38
1.3
1.2
—
—
—
0
0
112
686
2.20
8.07
2.5
1.7
17.83
20.58
nmol/l
1.17
101
567
21
52
4.33
7.99
1.3
1.2
—
—
—
0
0
20
48
4.46
7.90
1.7
1.4
—
—
—
0
0
146
999
2.20
7.88
2.9
2.1
91.39
96.34
pmol/l
0.76
99
510
12
8
15.71
7.80
1.8
1.0
89.75
102.63
%
—
12
8
22
58
4.08
7.72
1.8
1.4
—
—
—
0
0
158
1122
2.22
7.68
3.7
2.8
—
—
—
0
0
71
373
2.29
7.33
5.2
3.2
4.95
2.29
e6/l
0.75
39
183
27
86
3.41
7.25
2.0
3.2
—
—
—
0
0
75
409
2.22
7.04
4.9
3.0
1.05
1.14
e6/l
0.12
43
214
137
946
2.06
6.84
7.5
4.2
97.63
38.35
ng/l
0.55
119
740
21
59
3.81
6.76
1.6
1.2
—
—
—
0
0
12
12
10.46
6.61
1.4
1.2
—
—
—
0
0
33
126
2.88
6.55
5.7
3.6
24.35
24.91
mmol/l
0.36
33
121
36
147
2.71
6.31
6.8
4.6
57.26
47.37
%
1.56
36
142
31
118
2.87
6.19
13.9
5.0
1.88
1.54
%
1.47
31
111
132
925
1.96
6.05
2.9
2.5
77.49
77.56
nmol/l
0.01
121
818
16
40
4.22
6.00
1.2
1.1
—
—
—
0
0
77
448
2.06
5.99
4.2
3.1
2.48
2.45
mmol/l
0.83
66
404
11
14
8.18
5.40
1.4
1.0
—
—
—
0
0
10
11
9.43
5.34
1.7
2.2
—
—
—
0
0
10
11
9.43
5.34
1.7
2.2
—
—
—
0
0
19
60
3.36
5.16
1.4
1.4
—
—
—
0
0
14
28
5.25
5.03
1.7
1.9
—
—
—
0
0
15
33
4.78
4.96
1.9
1.3
—
—
—
0
0
100
673
1.84
4.89
6.5
4.4
0.00
0.01
estimate
0.50
36
243
13
26
5.23
4.70
1.8
1.9
—
—
—
0
0
57
328
1.97
4.44
1.4
1.3
22.01
9.58
u/ml
0.50
22
137
168
1348
1.85
4.38
7.0
3.4
76.51
53.82
u/l
2.84
163
1265
8
9
9.15
4.31
2.3
1.1
—
—
—
0
0
43
227
2.09
4.22
1.7
1.7
1.73
1.60
%
0.36
35
188
9
13
7.15
4.20
7.0
3.7
1.22
0.77
index
—
9
13
17
58
3.08
4.10
2.0
1.3
—
—
—
0
0
11
22
5.19
4.05
1.1
1.6
—
—
—
0
0
11
23
4.96
3.92
1.7
1.5
—
—
—
0
0
19
72
2.78
3.83
2.2
1.7
—
—
—
0
0
20
78
2.71
3.83
2.4
1.8
—
—
—
0
0
13
35
3.87
3.65
4.0
2.3
31.92
33.77
pg
1.00
13
35
13
35
3.87
3.65
2.0
1.4
—
—
—
0
0
10
21
4.92
3.59
1.7
2.0
—
—
—
0
0
10
21
4.92
3.59
1.1
1.0
—
—
—
0
0
10
21
4.92
3.59
1.7
2.0
—
—
—
0
0
10
21
4.92
3.59
1.7
2.0
—
—
—
0
0
106
779
1.65
3.50
3.8
4.0
18.73
7.86
mg/mmol
0.73
83
497
23
101
2.41
3.49
1.8
2.1
40.39
40.52
u/l
0.01
18
90
118
899
1.62
3.33
6.6
4.4
0.00
0.04
estimate
1.41
36
221
8
15
5.48
3.22
1.9
2.5
—
—
—
0
0
8
15
5.48
3.22
2.3
1.3
594.63
594.90
e6/l
—
8
10
8
16
5.13
3.07
1.3
2.0
12.10
12.57
umol/l
—
8
16
181
1550
1.71
3.07
5.2
4.2
15.37
14.99
pmol/l
1.18
170
1394
10
26
3.97
3.01
1.7
1.5
92624.00
30293.21
e6/l
—
5
14
58
378
1.71
2.95
1.6
1.3
31.37
39.36
iu/ml
0.34
19
120
8
18
4.56
2.82
1.6
1.1
—
—
—
0
0
72
505
1.61
2.75
6.8
4.9
1.02
1.02
kg/l
1.57
56
327
27
141
2.03
2.74
4.4
3.6
2.66
1.97
mmol/l
0.52
19
104
41
251
1.77
2.59
6.9
3.4
—
—
—
0
0
5
7
7.27
2.56
1.0
2.1
—
—
—
0
0
5
7
7.27
2.56
1.0
2.1
—
—
—
0
0
11
37
3.07
2.52
1.2
1.3
—
—
—
0
0
11
37
3.07
2.52
1.2
1.3
—
—
—
0
0
9
26
3.56
2.51
2.0
1.6
—
—
—
0
0
7
16
4.47
2.49
3.0
1.5
—
—
—
0
0
8
22
3.73
2.38
1.9
1.3
—
—
—
0
0
8
22
3.73
2.38
1.9
1.3
—
—
—
0
0
8
22
3.73
2.38
1.9
1.3
—
—
—
0
0
5
8
6.35
2.38
1.0
2.1
—
—
—
0
0
5
8
6.35
2.38
1.0
2.0
—
—
—
0
0
5
8
6.35
2.38
1.0
2.1
—
—
—
0
0
5
8
6.35
2.38
1.0
2.1
—
—
—
0
0
5
8
6.35
2.38
4.0
1.9
0.67
0.61
mmol/l
—
5
8
5
8
6.35
2.38
1.0
2.1
—
—
—
0
0
15
65
2.40
2.37
1.2
1.3
—
—
—
0
0
15
65
2.40
2.37
1.2
1.3
—
—
—
0
0
8
23
3.56
2.29
1.9
1.3
—
—
—
0
0
8
23
3.56
2.29
1.9
1.3
—
—
—
0
0
8
23
3.56
2.29
1.9
1.3
—
—
—
0
0
32
195
1.74
2.06
3.7
3.7
1.22
1.22
mmol/l
0.05
32
172
6
15
4.07
2.05
7.7
3.1
0.83
1.00
%
—
6
15
5
11
4.62
1.95
1.8
2.7
9.00
5.17
ug/l
—
5
11
6
16
3.82
1.94
1.0
1.0
—
—
—
0
0
66
488
1.49
1.93
1.9
1.9
483.28
439.76
pmol/l
0.58
57
400
6
17
3.59
1.85
1.7
1.2
—
—
—
0
0
6
18
3.39
1.76
1.2
1.1
—
—
—
0
0
7
24
2.97
1.73
1.6
1.3
—
—
—
0
0
204
1885
1.59
1.69
6.4
5.2
1.95
1.97
mu/l
0.09
197
1710
209
1943
1.64
1.68
8.7
7.0
41.66
39.89
mmol/mol
1.42
193
1814
5
14
3.62
1.62
1.0
1.1
80.80
102.64
pmol/l
—
5
14
211
1973
1.63
1.57
46.8
17.1
75.60
78.02
ml/min/173m2
0.75
205
1844
18
101
1.85
1.53
2.5
1.4
0.37
0.31
mg/l
—
9
43
81
652
1.37
1.45
5.6
3.8
0.03
0.00
estimate
0.49
35
208
17
96
1.83
1.43
1.4
1.3
—
—
—
0
0
11
53
2.13
1.41
1.5
1.7
7.36
3.53
mg/l
0.61
11
41
12
60
2.05
1.40
1.8
1.6
—
—
—
0
0
211
1985
1.57
1.37
6.2
5.4
6.41
6.04
mmol/l
2.28
190
1812
6
24
2.54
1.31
1.0
1.3
—
—
—
0
0
6
24
2.54
1.31
1.5
1.1
—
—
—
0
0
9
44
2.09
1.28
3.4
3.4
6.78
10.06
pmol/l
—
9
44
35
248
1.48
1.26
17.2
8.5
—
—
—
0
0
8
36
2.26
1.25
2.4
4.1
—
—
—
0
0
6
25
2.44
1.25
1.5
1.1
—
—
—
0
0
6
25
2.44
1.25
1.5
1.1
—
—
—
0
0
6
25
2.44
1.25
1.5
1.1
—
—
—
0
0
10
49
2.09
1.24
1.4
1.3
—
—
—
0
0
204
1916
1.46
1.22
5.4
4.5
1.49
1.27
mmol/l
4.02
185
1755
10
50
2.04
1.18
1.1
1.4
—
—
—
0
0
182
1686
1.34
1.11
67.6
21.4
15.19
13.72
%
15.83
182
1671
5
21
2.41
1.09
1.0
1.2
1.53
1.48
g/l
—
5
21
5
22
2.30
1.04
1.0
1.2
—
—
—
0
0
9
49
1.87
1.00
1.1
1.1
—
2.99
—
0
8
5
23
2.20
0.98
1.0
1.7
—
—
—
0
0
213
2036
1.46
0.95
6.8
6.2
2.31
2.62
mmol/l
6.54
196
1881
225
2176
1.67
0.94
79.2
26.5
123.18
134.88
g/l
16.39
225
2154
58
473
1.30
0.93
1.4
1.3
1.04
1.64
u/ml
0.57
11
146
6
28
2.17
0.92
1.5
1.1
—
—
—
0
0
6
28
2.17
0.92
1.5
1.1
—
—
—
0
0
6
29
2.10
0.90
1.0
1.1
—
0.96
—
0
7
15
226
0.64
0.88
1.3
1.5
—
—
—
0
0
10
58
1.76
0.81
1.9
1.9
—
—
—
0
0
25
184
1.40
0.78
4.3
3.1
54.93
61.67
ml/min/173m2
0.40
15
81
7
39
1.82
0.73
5.0
3.5
1.21
1.19
mmol/l
—
7
39
7
39
1.82
0.73
5.0
3.5
103.71
105.67
mmol/l
—
7
39
208
1998
1.34
0.72
6.1
5.5
4.03
4.50
mmol/l
9.47
193
1849
0
20
0.00
0.60
0.0
1.4
—
51.61
—
0
20
0
21
0.00
0.60
0.0
1.0
—
41.24
—
0
12
0
21
0.00
0.60
0.0
1.0
—
527.92
—
0
13
206
1990
1.27
0.56
6.0
5.3
1.18
1.43
mmol/l
14.82
186
1833
23
184
1.28
0.45
1.5
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
13
97
1.36
0.40
1.1
1.1
—
—
—
0
0
15
115
1.32
0.40
1.4
1.2
200.27
561.38
u/ml
0.71
15
108
9
71
1.28
0.36
3.2
2.0
—
—
—
0
0
6
43
1.41
0.35
2.2
1.8
—
—
—
0
0
8
62
1.30
0.28
3.4
1.8
—
—
—
0
0
5
41
1.22
0.22
5.0
2.4
10.40
10.61
mmol/l
—
5
41
0
10
0.00
0.21
0.0
1.7
—
8.01
—
0
10
5
43
1.17
0.21
1.0
1.1
—
3.88
—
0
6
91
867
1.08
0.20
2.0
2.0
1.52
1.29
mmol/l
2.36
81
701
35
318
1.12
0.20
1.5
1.5
—
—
—
0
0
24
261
0.91
0.12
5.5
4.9
32.06
32.06
%
0.00
16
169
5
44
1.14
0.10
1.0
1.5
—
—
—
0
0
16
145
1.11
0.09
2.5
1.8
—
—
—
0
0
53
510
1.05
0.08
2.5
3.4
0.67
0.83
ug/l
0.73
32
341
17
156
1.10
0.08
2.6
2.0
—
—
—
0
0
68
698
0.96
0.06
3.4
4.8
22.41
22.14
%
0.04
31
352
89
881
1.02
0.02
5.0
5.6
4.75
2.62
ug/l
0.44
78
787
0
9
0.00
0.00
0.0
1.0
—
41.56
—
0
9
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
23.09
—
0
7
0
6
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
-0.00
2.4
1.2
1.00
0.85
g/l
—
5
50
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_INFARCTSPLEEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_INFARCTSPLEEN | 4.274 [2.49, 7.33] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.268 |
During the follow-up period (1.1.1998 — 31.12.2019), 141 out of 337 females with D3_INFARCTSPLEEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_INFARCTSPLEEN | 3.945 [2.59, 6.01] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 407 males with D3_INFARCTSPLEEN died.
Mortality risk
Mortality risk for people of age
years, who have D3_INFARCTSPLEEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.375% | 0.58% |
| 5 | 2.654% | 3.864% |
| 10 | 6.187% | 9.639% |
| 15 | 12.077% | 17.816% |
| 20 | 20.399% | 28.01% |
Relationships between endpoints
↥Index endpoint: D3_INFARCTSPLEEN – Infarction of spleen
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data