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Hypersplenism

DOID EFO Endpoint Browser PheWeb

D3_HYPERSPLENISM

hypersplenism: Overactive functioning of the spleen, resulting in excessive destruction of blood cells.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D73.1
  • Hospital discharge: ICD-9 — 2894
  • Cause of death: ICD-10 — D73.1
  • Cause of death: ICD-9 — 2894

2 out of 7 registries used, show all original rules.

162

4. Check minimum number of events

None

162

5. Include endpoints

None

162

6. Filter based on genotype QC (FinnGen only)

158

Control definitions (FinnGen only)

Control exclude
D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D73
Name in latin
Hypersplenismus

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1082 469 602
Only index persons 882 381 501
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 58.66 59.57 57.67
Only index persons 56.73 57.62 56.06

-FinnGen-

Key figures

All Female Male
Number of individuals 158 72 86
Unadjusted period prevalence (%) 0.03 0.03 0.04
Median age at first event (years) 58.41 56.36 60.12

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
162
Matched controls
1620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.1
ICD-10 Finland
Hypersplenism
+∞
225.4
159
*
XW000
NOMESCO Finland
Bone marrow biopsy
36.7
82.6
56
23
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
11.1
52.0
77
122
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
76.4
32.6
36
6
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
382.7
32.0
31
*
D64.9
ICD-10 Finland
Anaemia, unspecified
8.2
32.0
53
91
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.2
30.5
95
300
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
11.8
28.6
32
33
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
7.1
24.5
44
81
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.1
22.5
48
104
C03CA01
ATC
furosemide; systemic
4.5
20.4
81
292
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
36.6
19.9
25
8
J01MA12
ATC
levofloxacin; systemic
4.7
19.2
60
179
R50.9
ICD-10 Finland
Fever, unspecified
4.8
18.7
56
161
JMA10
NOMESCO Finland
Transabdominal total splenectomy
106.9
18.0
19
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
71.2
17.1
19
*
D70.89
ICD-10 Finland
Neutropenic splenomegaly
188.6
16.8
17
*
JN4BD
NOMESCO Finland
Extensive body CT
5.1
16.3
41
101
WW500
NOMESCO Finland
Blood transfusion
13.8
16.3
28
24
C03DA01
ATC
spironolactone; oral
4.9
16.0
43
112
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
15.8
111
569
ZX120
NOMESCO Finland
Intravenous
5.3
15.4
36
83
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
6.4
15.4
28
51
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
+∞
14.8
14
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.1
13.8
26
49
JN4AD
NOMESCO Finland
Body CT examination
4.4
12.8
38
106
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.6
12.1
33
86
TPH04
NOMESCO Finland
Cathetrisation of vein
3.4
11.6
57
224
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
128.8
11.6
12
*
TPH07
NOMESCO Finland
Cathetrisation of artery
4.4
11.4
32
85
A05AA02
ATC
ursodeoxycholic acid; oral
27.3
11.4
15
6
WW200
NOMESCO Finland
Immunization
14.3
11.0
18
14
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
30.4
10.9
14
5
M04AA01
ATC
allopurinol; systemic
3.7
10.4
39
128
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.1
10.3
60
259
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
28.0
10.0
13
5
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.7
9.9
37
121
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
58.6
9.8
11
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
9.8
45
168
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
+∞
9.5
9
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
16.9
9.2
14
9
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.7
9.1
32
100
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.6
9.1
23
56
JN3AD
NOMESCO Finland
Abdominal CT examination
3.5
9.0
36
122
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
8.9
78
413
127
Kela drug reimbursment
Transplant complication
21.4
8.6
12
6
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
94.8
8.5
9
*
L04AD02
ATC
tacrolimus; systemic
94.8
8.5
9
*
9689/3-C42.2
ICD-O-3
Splenic marginal zone B-cell lymphoma of spleen
+∞
8.4
8
*
K92.1
ICD-10 Finland
Melaena
5.2
8.3
18
38
C07AB07
ATC
bisoprolol; oral
2.6
8.2
94
560
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
23.4
8.1
11
5
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.5
8.1
21
52
R18
ICD-10 Finland
Ascites
14.0
8.0
13
10
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.8
7.9
19
44
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
16.1
7.8
12
8
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
47.3
7.8
9
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
26.4
7.7
10
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.7
7.7
27
84
JN6AD
NOMESCO Finland
CT of torso and neck
14.3
7.5
12
9
UJF32
NOMESCO Finland
Coloscopy
2.7
7.5
55
262
I81
ICD-10 Finland
Portal vein thrombosis
83.8
7.5
8
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
83.8
7.5
8
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
16.7
7.3
11
7
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
7.3
49
223
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
10.8
7.2
13
13
L01XX05
ATC
hydroxycarbamide; oral
14.6
7.0
11
8
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
8.9
7.0
14
17
C07AG02
ATC
carvedilol; oral
4.4
6.8
18
45
120
Kela drug reimbursment
Hypogammaglobulinaemia
41.9
6.8
8
*
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
8.4
6.8
14
18
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
23.7
6.7
9
*
A46
ICD-10 Finland
Erysipelas
2.9
6.7
38
157
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
6.7
6.7
16
26
A10AE04
ATC
insulin glargine; parenteral
3.2
6.6
28
98
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
8.0
6.6
14
19
I50.0
ICD-10 Finland
Congestive heart failure
3.9
6.5
20
56
GD1AD
NOMESCO Finland
Thorax CT examination
3.9
6.5
20
56
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
15.1
6.5
10
7
L01EJ01
ATC
ruxolitinib; oral
72.6
6.5
7
*
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
72.6
6.5
7
*
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
72.6
6.5
7
*
374
Kela drug reimbursment
Ruxolitinib
72.6
6.5
7
*
174
Kela drug reimbursment
Ruxolitinib
72.6
6.5
7
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
7.6
6.4
14
20
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
27.9
6.3
8
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
6.3
6
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
+∞
6.3
6
*
A07AA11
ATC
rifaximin; oral
+∞
6.3
6
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
7.7
6.1
13
18
A06AD11
ATC
lactulose; oral
2.8
6.0
33
134

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Thrombocytopenia, unspecified
D69.6 (45581327)
Hypersplenism
D73.1 (45595776)
B-cell lymphoma in marginal zone
C83.80 (2000501237)
Bone marrow biopsy
XW000 (2001310618)
IgM [Mass/volume] in Serum or Plasma
2472-9 (3028026)
Morphology [Interpretation] in Bone marrow Narrative
51628-6 (3042111)
Bone marrow Pathology biopsy report
33721-2 (3045142)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Other and unspecified cirrhosis of liver
K74.6 (45538546)
Anaemia, unspecified
D64.9 (45600610)
Thorax X-ray examination
GD1AA (2001303617)
Esophagoscopy, gastroscopy and duodenoscopy
UJD10 (2001304788)
Abdominal ultrasound examination
JN3AE (2001305555)
SMOKING - SMOKE2: no - SMOKE3: never - SMOKE5: Unspecified
SMOKING-2-3-0 (2002330113)
Monocytes [#/volume] in Blood
26484-6 (3001604)
Lymphocytes/Leukocytes in Blood
26478-8 (3002030)
IgG [Mass/volume] in Serum or Plasma
2465-3 (3005719)
Bilirubin.total [Moles/volume] in Serum or Plasma
14631-6 (3006140)
Basophils [#/volume] in Blood
26444-0 (3006315)
Eosinophils/Leukocytes in Blood
26450-7 (3006504)
Kappa light chains/Lambda light chains [Mass Ratio] in Serum
15189-4 (3007778)
Eosinophils [#/volume] in Blood
26449-9 (3013115)
Neutrophils [#/volume] in Blood by Automated count
751-8 (3013650)
Neutrophils/Leukocytes in Blood
26511-6 (3018010)
Monocytes/Leukocytes in Blood
26485-3 (3019069)
Lymphocytes [#/volume] in Blood
26474-7 (3019198)
Basophils/Leukocytes in Blood
30180-4 (3022096)
Bacteria identified in Blood by Culture
600-7 (3023368)
Reticulocytes [#/volume] in Blood
14196-0 (3023520)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
INR in Blood by Coagulation assay
34714-6 (3032080)
Prothrombin time (PT) actual/Normal
5894-1 (3033658)
Kappa light chains.free [Mass/volume] in Serum
36916-5 (3034860)
Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
6768-6 (3035995)
Lambda light chains.free [Mass/volume] in Serum or Plasma
33944-0 (3047169)
Gastroenterology
10 (38004455)
Infectious Disease
44 (38004484)
Hematology
82 (38004501)
Emergency Medicine
93 (38004510)
CBC W Ordered Manual Differential panel - Blood
57782-5 (40760892)
Differential panel, method unspecified - Blood
69738-3 (42870588)
Essential (primary) hypertension
I10 (45591453)
Inpatient Hospital
21 (8717)
Outpatient Hospital
22 (8756)
Emergency Room Visit
ER (9203)
Reticulocytes/Erythrocytes in Blood
4679-7 (3027945)
Outpatient Visit
OP (9202)
Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
14804-9 (3022250)
Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1920-8 (3013721)
Calcium.ionized [Moles/volume] in Serum or Plasma
1995-0 (3021347)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
19072-8 (3016431)
Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method
4537-7 (3013707)
Ferritin [Mass/volume] in Serum or Plasma
2276-4 (3001122)
Internal Medicine
11 (38004456)
Upper gastrointestinal surgery
106 (44777669)
Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
30248-9 (3015399)
Blood group antibody screen [Presence] in Serum or Plasma
890-4 (3001079)
Laboratory Visit
OMOP4822461 (32036)
Normoblasts [#/volume] in Blood
715-3 (3021589)
Prealbumin [Mass/volume] in Serum or Plasma
14338-8 (3013742)
Iron/Transferrin [Ratio] in Serum or Plasma
60517-0 (40763571)
Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
2324-2 (3026910)
furosemide; oral, parenteral
C03CA01 (21601518)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
Transferrin [Mass/volume] in Serum or Plasma
3034-6 (3004789)
Iron [Moles/volume] in Serum or Plasma
14798-3 (3022948)
Blood type and Crossmatch panel - Blood
34531-4 (3044640)
Supplier / Service Provider
OMOP5117446 (33004)
Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1742-6 (3006923)
IgA [Mass/volume] in Serum or Plasma
2458-8 (3007164)
Case Management Agency
251B00000X (38004193)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
aPTT in Platelet poor plasma by Coagulation assay
14979-9 (3018677)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
Hepatitis B virus surface Ag [Presence] in Serum
5195-3 (3019284)
Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M
62238-1 (40764999)
Magnesium [Moles/volume] in Serum or Plasma
2601-3 (3012095)
Urate [Moles/volume] in Serum or Plasma
14933-6 (3026493)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
Platelets [#/volume] in Blood
26515-7 (3007461)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
MCH [Entitic mass]
28539-5 (3035941)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
CBC panel - Blood by Automated count
58410-2 (40761511)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
Phosphate [Moles/volume] in Serum or Plasma
14879-1 (3003458)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)
Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay
3255-7 (3016407)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
45
12
51.54
74.98
1.8
1.2
—
—
—
0
0
64
79
12.74
52.23
3.0
1.9
1.24
1.64
g/l
0.43
58
73
86
156
10.62
51.94
5.3
2.6
2.31
1.65
%
2.78
80
139
70
109
10.55
47.49
4.5
2.6
0.18
0.22
g/l
2.32
65
101
73
124
9.90
45.95
6.1
2.5
83.64
66.30
e9/l
2.12
58
89
60
87
10.37
42.71
2.0
1.8
—
—
—
0
0
38
39
12.42
34.37
1.3
1.1
—
—
—
0
0
124
464
8.13
33.91
19.1
5.8
—
—
—
0
0
36
38
11.89
31.84
2.3
3.6
1.77
2.08
ratio
0.13
22
19
77
195
6.62
31.73
4.3
2.4
21.96
23.84
%
0.45
72
183
30
27
13.41
29.32
1.7
1.3
—
—
—
0
0
42
63
8.65
28.30
3.0
1.7
0.79
1.51
g/l
5.38
30
55
68
185
5.61
25.09
1.9
1.5
—
—
—
0
0
136
667
7.47
24.38
20.8
6.2
2.93
2.76
%
0.23
131
636
136
668
7.45
24.31
21.1
6.4
0.82
0.69
%
0.54
131
633
136
672
7.38
24.02
21.5
6.5
9.04
8.76
%
0.44
131
642
74
224
5.24
23.92
2.1
1.6
—
—
—
0
0
29
9
38.81
23.35
1.2
1.0
—
—
—
0
0
98
380
5.00
23.05
10.7
4.7
—
—
—
0
0
68
201
5.11
22.41
1.8
1.4
517.33
525.45
titre
0.01
15
44
27
9
35.60
21.36
1.1
1.0
—
—
—
0
0
52
128
5.51
21.13
1.6
1.5
—
—
—
0
0
29
39
8.84
21.09
1.5
1.3
—
—
—
0
0
131
672
5.96
20.77
20.0
6.3
58.35
58.07
%
0.09
126
648
50
121
5.53
20.68
1.8
1.3
—
—
—
0
0
85
316
4.56
20.60
3.5
2.1
3.40
2.83
mg/l
1.18
75
277
59
167
4.98
20.26
9.9
2.9
11.76
4.88
umol/l
2.84
52
145
47
110
5.61
20.14
10.4
5.8
0.83
0.28
%
1.25
35
38
138
751
6.65
20.02
20.4
6.3
0.21
0.19
e9/l
0.24
121
659
48
117
5.41
19.60
11.3
5.7
1.28
0.95
%
0.32
37
43
136
743
6.17
19.29
19.4
6.3
1.54
1.87
e9/l
2.38
126
657
134
736
5.75
18.53
19.3
6.1
0.55
0.58
e9/l
0.16
121
632
134
737
5.73
18.47
19.2
6.1
0.05
0.04
e9/l
0.24
120
632
29
21
16.54
18.13
2.1
5.1
—
—
—
0
0
79
301
4.17
18.03
2.7
1.4
2.52
2.55
g/l
0.03
62
180
141
821
6.53
17.75
25.4
9.5
4.36
4.16
e9/l
0.14
130
708
44
108
5.22
17.70
11.2
6.0
0.15
0.18
%
0.09
33
34
73
280
3.93
16.18
2.2
1.8
—
—
—
0
0
59
196
4.16
16.02
2.1
1.7
1253.33
1203.06
nmol/l
0.14
47
161
43
112
4.87
16.01
11.9
6.7
0.31
0.26
%
0.06
32
34
27
26
12.22
14.92
1.9
1.2
148.60
169.29
au/ml
—
5
7
22
13
19.35
14.78
2.7
1.8
35.71
42.78
%
0.78
22
13
19
7
30.45
14.65
3.8
2.6
1460.21
708.57
u/ml
—
19
7
114
619
3.84
14.37
27.7
12.5
1.37
1.22
inr
2.18
105
520
20
10
22.57
14.18
1.2
1.4
—
—
—
0
0
119
669
3.93
14.12
16.2
7.7
1.19
1.21
mmol/l
1.88
105
593
25
23
12.63
14.10
1.6
1.2
272.50
175.36
u/ml
0.53
12
14
25
29
9.98
12.57
1.1
1.3
—
—
—
0
0
89
447
3.20
12.05
5.7
2.8
57.30
72.91
u/l
0.51
83
417
56
222
3.33
11.18
3.8
2.5
—
—
—
0
0
27
65
4.78
10.84
2.7
3.1
14.06
7.44
iu/ml
—
5
15
48
177
3.43
10.71
1.6
1.3
—
—
—
0
0
20
37
6.03
10.70
1.1
1.3
—
—
—
0
0
20
21
10.69
10.61
1.1
1.0
—
—
—
0
0
86
449
2.95
10.47
8.0
2.3
—
—
—
0
0
22
47
5.26
10.11
2.3
1.9
1.08
1.16
g/l
0.61
22
47
18
17
11.75
10.07
1.2
1.0
—
—
—
0
0
43
157
3.37
9.66
1.9
1.8
—
—
—
0
0
37
129
3.42
8.89
13.8
8.4
—
—
—
0
0
79
423
2.69
8.76
9.0
4.0
7.40
7.40
ph
0.06
66
308
22
55
4.47
8.38
2.6
1.8
2.05
1.36
ug/l
0.19
22
49
13
9
15.56
8.36
1.5
1.7
3.94
4.60
mg/l
—
13
9
24
67
4.03
7.92
5.4
3.2
—
—
—
0
0
95
583
2.52
7.61
3.1
2.0
101.58
95.66
pmol/l
0.43
61
298
103
658
2.55
7.55
7.4
2.9
—
—
estimate
—
0
0
14
15
10.09
7.45
4.9
1.3
33.00
34.00
pg
0.37
14
15
61
313
2.52
7.09
4.2
2.7
4.96
3.96
e6/l
0.25
61
285
40
171
2.78
6.66
10.6
10.3
7.42
7.42
ph
0.02
23
108
12
12
10.69
6.65
2.9
3.1
43.22
40.27
%
—
6
6
60
315
2.44
6.55
3.0
1.6
1.62
1.00
mg/l
0.89
47
248
36
147
2.86
6.52
7.2
3.5
1.71
1.88
mmol/l
0.13
31
123
13
16
8.72
6.47
1.2
1.3
—
—
—
0
0
12
13
9.86
6.41
2.3
1.1
—
—
—
0
0
37
155
2.80
6.38
7.5
3.6
7.37
7.38
ph
0.71
26
98
9
5
18.94
6.34
2.8
1.4
22.44
23.40
%
—
9
5
9
5
18.94
6.34
1.2
1.0
—
—
—
0
0
39
169
2.72
6.30
10.4
10.4
0.98
1.25
mmol/l
0.15
34
144
24
80
3.35
6.10
10.8
14.4
14.45
15.87
%
1.96
24
80
9
6
15.77
5.97
1.0
1.7
—
—
—
0
0
12
15
8.54
5.95
1.3
1.3
6.52
5.53
g/l
—
7
9
12
15
8.54
5.95
1.3
1.3
0.59
0.36
g/l
—
7
9
14
23
6.55
5.84
5.3
3.3
3.87
4.52
e9/l
0.23
14
23
77
469
2.22
5.80
5.4
3.2
43.09
168.29
e6/l
0.42
63
352
12
16
8.00
5.74
1.3
1.3
—
—
—
0
0
11
13
8.98
5.65
1.5
1.0
—
—
—
0
0
16
34
5.10
5.47
6.1
3.1
58.38
60.56
%
0.18
16
34
14
26
5.79
5.36
1.3
2.5
0.44
1.03
g/l
—
9
20
82
524
2.14
5.36
6.4
3.7
52.63
92.64
e6/l
0.49
65
367
39
184
2.47
5.25
2.6
1.6
—
—
—
0
0
23
82
3.10
5.24
13.8
8.3
24.27
24.94
mmol/l
0.32
23
82
64
377
2.15
5.11
4.6
3.0
—
—
—
0
0
67
403
2.13
5.06
5.4
3.1
0.25
0.46
e6/l
1.05
52
288
59
340
2.16
4.95
13.1
5.3
—
—
—
0
0
32
145
2.50
4.66
11.7
11.6
111.44
122.01
g/l
2.01
32
145
21
76
3.03
4.66
2.1
1.4
0.25
0.33
mg/l
—
10
35
7
5
14.54
4.62
4.3
2.2
0.64
0.61
mmol/l
—
7
5
32
147
2.47
4.52
2.6
5.1
2.69
35.07
ug/l
0.61
27
126
35
172
2.32
4.26
1.6
1.4
—
—
—
0
0
55
330
2.01
4.02
1.4
1.3
0.89
1.20
u/ml
0.31
15
102
22
89
2.70
4.00
4.1
9.6
—
—
—
0
0
29
135
2.40
3.97
1.6
1.6
—
—
—
0
0
11
24
4.84
3.82
2.2
1.8
—
—
—
0
0
11
24
4.84
3.82
2.2
1.8
—
—
—
0
0
11
24
4.84
3.82
2.2
1.7
—
—
—
0
0
11
24
4.84
3.82
2.2
1.8
—
—
—
0
0
8
12
6.95
3.72
1.0
1.3
—
—
—
0
0
64
415
1.90
3.68
13.0
6.1
—
—
—
0
0
33
169
2.20
3.62
4.9
3.8
8.83
5.54
e9/l
0.40
28
148
37
199
2.11
3.59
13.6
6.8
103.30
104.10
mmol/l
0.45
37
199
88
637
1.84
3.53
34.2
11.0
0.08
0.00
e9/l
0.78
78
516
40
225
2.03
3.45
3.9
2.9
1.89
1.66
e6/l
0.09
18
113
13
38
3.63
3.40
7.8
3.0
7.39
7.42
ph
1.08
13
38
21
91
2.50
3.34
4.8
2.5
2.20
1.41
%
0.86
21
91
9
19
4.95
3.29
1.1
1.2
—
—
—
0
0
11
29
3.99
3.25
7.0
22.7
104.91
105.62
mmol/l
0.17
11
29
11
29
3.99
3.25
7.0
22.7
10.82
10.69
mmol/l
0.04
11
29
8
15
5.55
3.23
1.0
1.3
—
—
—
0
0
8
15
5.55
3.23
2.3
2.0
—
—
—
0
0
20
87
2.48
3.16
1.8
1.2
—
—
—
0
0
6
8
7.73
3.08
1.2
1.1
—
—
—
0
0
98
753
1.76
3.05
5.7
3.6
88.72
0.00
estimate
0.79
29
168
5
5
10.26
3.00
1.2
1.0
—
—
—
0
0
81
593
1.73
2.96
4.7
3.3
6.17
6.14
ph
0.12
46
353
8
17
4.89
2.96
1.8
2.4
—
—
—
0
0
76
547
1.73
2.95
7.7
3.8
27.54
36.15
ng/l
0.55
61
385
10
27
3.88
2.93
8.5
2.4
7.86
8.72
kpa
—
10
27
10
27
3.88
2.93
8.5
2.4
4.78
4.86
kpa
—
10
27
96
744
1.71
2.80
5.8
3.6
0.00
0.00
estimate
-0.00
27
165
13
48
2.86
2.79
1.8
2.7
—
—
—
0
0
5
6
8.55
2.77
4.8
1.0
—
—
—
0
0
97
756
1.71
2.75
5.7
3.7
0.00
0.00
estimate
-0.00
25
151
6
10
6.18
2.72
1.3
1.1
—
—
—
0
0
7
15
4.82
2.62
3.1
1.7
8.54
10.71
%
—
7
15
40
247
1.82
2.58
1.4
1.3
37.35
4.60
u/ml
—
10
100
5
7
7.32
2.56
1.2
1.3
—
—
iu/ml
—
0
0
65
463
1.67
2.54
5.7
4.2
33.85
11.48
mg/mmol
0.85
44
309
9
26
3.60
2.52
2.1
2.8
—
—
—
0
0
19
90
2.26
2.50
1.2
1.2
26.89
138.63
u/ml
—
8
32
10
32
3.26
2.48
8.0
2.6
—
—
—
0
0
6
12
5.15
2.42
1.0
1.1
—
—
—
0
0
7
18
4.01
2.28
1.3
1.2
—
—
—
0
0
18
87
2.20
2.27
4.7
2.5
0.70
0.61
%
0.65
18
87
62
448
1.62
2.24
4.4
3.5
213.38
68.16
mg/l
1.00
42
307
5
9
5.69
2.23
1.6
1.2
—
—
—
0
0
11
42
2.73
2.19
1.2
1.2
—
—
—
0
0
42
276
1.70
2.17
1.5
1.3
124.81
34.24
iu/ml
0.54
16
88
73
553
1.58
2.15
2.2
2.0
—
—
—
0
0
40
576
0.59
2.14
3.5
3.2
—
—
—
0
0
8
25
3.31
2.12
1.4
1.5
—
—
—
0
0
59
428
1.60
2.07
3.4
2.0
103.59
225.35
u/l
1.96
59
410
6
15
4.11
2.06
1.2
1.2
—
—
—
0
0
58
421
1.59
2.02
6.5
3.6
3.13
0.00
estimate
0.48
24
151
64
477
1.56
1.99
4.5
3.3
7.04
8.29
mmol/l
1.72
54
407
6
16
3.85
1.95
1.3
1.3
—
—
—
0
0
39
259
1.67
1.93
5.6
3.8
584.23
489.35
ng/l
0.06
33
203
120
1034
1.62
1.93
5.0
4.2
14.68
14.86
pmol/l
0.41
113
956
5
12
4.26
1.83
1.4
1.5
—
—
—
0
0
19
103
1.96
1.81
3.2
2.3
17.28
9.39
ug/l
0.35
13
92
55
404
1.55
1.79
1.8
1.4
—
—
—
0
0
13
62
2.19
1.71
1.2
1.1
—
—
—
0
0
149
1381
1.98
1.58
54.9
15.5
23.18
24.38
mg/l
0.21
144
1127
61
471
1.47
1.54
6.0
3.5
—
—
—
0
0
12
59
2.12
1.47
2.9
2.3
—
—
—
0
0
55
420
1.47
1.46
5.2
3.1
10.87
0.01
estimate
0.48
23
128
6
22
2.79
1.45
11.3
3.4
13.93
9.36
pmol/l
—
6
22
45
332
1.49
1.41
5.2
3.5
1.02
1.02
kg/l
0.61
32
217
70
569
1.41
1.30
6.0
3.5
0.00
0.00
estimate
-0.00
25
134
5
18
2.83
1.29
4.4
3.4
3.42
3.09
nmol/l
—
5
18
6
25
2.45
1.25
1.3
1.1
—
—
—
0
0
6
25
2.45
1.25
3.7
1.8
—
—
—
0
0
6
25
2.45
1.25
1.3
1.1
—
—
—
0
0
15
90
1.73
1.08
1.4
1.3
—
—
—
0
0
5
22
2.31
1.04
3.4
1.1
—
—
—
0
0
127
1356
0.71
0.97
6.1
4.9
1.17
1.43
mmol/l
11.40
120
1271
21
144
1.53
0.93
2.9
1.5
—
—
—
0
0
25
179
1.47
0.91
1.0
1.2
—
—
—
0
0
122
1303
0.74
0.83
6.0
4.2
1.44
1.30
mmol/l
1.21
114
1217
0
27
0.00
0.78
0.0
3.3
—
18.78
—
0
27
17
116
1.52
0.78
10.0
3.6
—
—
—
0
0
131
1381
0.73
0.77
6.6
5.7
2.28
2.70
mmol/l
6.45
125
1294
125
1163
1.33
0.76
65.1
19.2
15.12
13.54
%
10.12
125
1156
129
1362
0.74
0.75
6.2
5.0
4.03
4.60
mmol/l
8.87
123
1283
7
42
1.70
0.69
1.7
1.2
—
—
—
0
0
136
1289
1.34
0.66
9.3
6.3
39.37
39.44
mmol/mol
0.02
126
1231
17
121
1.45
0.65
2.8
2.7
0.07
0.78
e6/l
0.48
17
115
11
71
1.59
0.64
5.0
4.0
37.02
37.00
°c
0.06
11
71
5
30
1.69
0.62
1.8
1.2
0.93
0.88
nmol/l
—
5
24
0
20
0.00
0.61
0.0
1.1
—
1.80
—
0
7
0
21
0.00
0.60
0.0
1.0
—
0.77
—
0
11
133
1265
1.29
0.56
6.3
5.0
2.10
1.93
mu/l
0.71
125
1172
13
168
0.75
0.38
1.7
1.4
—
—
—
0
0
15
124
1.23
0.25
1.2
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
0.14
—
0
7
0
13
0.00
0.21
0.0
1.2
—
169.03
—
0
13
6
49
1.23
0.20
3.0
1.1
0.69
0.86
g/l
—
6
49
29
319
0.89
0.18
3.1
3.0
0.72
0.74
ug/l
0.06
20
206
6
75
0.79
0.16
1.7
1.8
—
—
—
0
0
145
1429
1.14
0.14
48.5
13.8
—
—
—
0
0
6
57
1.05
0.08
1.0
1.0
—
—
—
0
0
133
1321
1.04
0.02
7.1
4.9
6.46
5.95
mmol/l
2.08
125
1228
12
119
1.01
0.00
1.9
2.1
6.00
6.12
ph
—
5
83
15
153
0.98
0.00
2.5
2.4
11.25
13.94
nmol/l
0.78
15
144
6
59
1.02
0.00
3.7
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
32.08
—
0
5
0
5
0.00
0.00
0.0
1.2
—
29.00
—
0
5
0
5
0.00
0.00
0.0
1.0
—
7.12
—
0
5
6
60
1.00
0.00
3.8
1.5
—
—
—
0
0
6
59
1.02
0.00
3.7
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
1.75
—
0
5
0
8
0.00
0.00
0.0
1.1
—
0.00
—
0
8
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
143.33
—
0
6
6
61
0.98
-0.00
3.8
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
49.50
—
0
6
6
61
0.98
-0.00
3.5
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
17.72
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint D3_HYPERSPLENISM and mortality.

Females

Parameter HR [95% CI] p-value
D3_HYPERSPLENISM 6.062 [3.72, 9.87] < 0.001
Birth year 0.995 [0.99, 1.0] 0.274

During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 361 females with D3_HYPERSPLENISM died.

Males

Parameter HR [95% CI] p-value
D3_HYPERSPLENISM 4.648 [3.31, 6.52] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 174 out of 469 males with D3_HYPERSPLENISM died.

Mortality risk

Mortality risk for people of age

years, who have D3_HYPERSPLENISM.

N-year risk Females Males
1 0.658% 0.829%
5 3.469% 5.303%
10 8.399% 13.102%
15 16.608% 22.798%
20 27.309% 36.245%

Relationships between endpoints

↥

Index endpoint: D3_HYPERSPLENISM – Hypersplenism

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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