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Hyposplenism

DOID EFO Endpoint Browser PheWeb

D3_HYPOSPLENISM

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D73.0
  • Cause of death: ICD-10 — D73.0

2 out of 7 registries used, show all original rules.

74

4. Check minimum number of events

None

74

5. Include endpoints

None

74

6. Filter based on genotype QC (FinnGen only)

51

Control definitions (FinnGen only)

Control exclude
D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D73
Name in latin
Hyposplenismus

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 277 148 127
Only index persons 251 138 113
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.01 0.00
Median age at first event (years)
Whole population 52.16 52.98 51.62
Only index persons 52.71 52.98 52.39

-FinnGen-

Key figures

All Female Male
Number of individuals 51 32 19
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 58.55 52.80 68.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
61
Matched controls
610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.0
ICD-10 Finland
Hyposplenism
+∞
87.5
61
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
249.6
18.6
18
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
9.9
17.9
29
51
XW000
NOMESCO Finland
Bone marrow biopsy
44.5
17.5
21
7
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
17.5
16
*
WX408
NOMESCO Finland
General anesthesy, balanced
8.1
15.4
35
87
XF400
NOMESCO Finland
ECG with 12 standard connections
8.4
15.1
28
56
WW200
NOMESCO Finland
Immunization
41.5
14.9
18
6
R4110
NOMESCO Finland
Physiotherapy
7.8
14.6
39
113
Z2221
NOMESCO Finland
Medical doctor
7.8
14.4
40
120
WW500
NOMESCO Finland
Blood transfusion
27.6
13.4
18
9
ZXD10
NOMESCO Finland
Scheduled procedure
7.5
13.0
44
156
ZXE10
NOMESCO Finland
More than one and less than three hours
6.5
12.0
39
131
TPH04
NOMESCO Finland
Cathetrisation of vein
6.2
11.5
30
82
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
35.5
11.3
14
5
ZX120
NOMESCO Finland
Intravenous
12.2
11.3
21
25
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
17.6
11.0
17
13
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
131.7
10.8
11
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
6.1
10.5
25
62
ZXE00
NOMESCO Finland
One hour or less
6.0
10.2
43
174
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
10.5
9.6
19
25
Z3226
NOMESCO Finland
Physiotherapist
5.4
9.2
25
69
ZXE20
NOMESCO Finland
More than three and less than five hours
6.1
8.8
19
42
R4190
NOMESCO Finland
Nutritional therapy
17.9
8.7
13
9
JN4BD
NOMESCO Finland
Extensive body CT
7.9
8.1
19
33
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.8
8.0
26
82
Z3231
NOMESCO Finland
Registered nurse
4.6
8.0
32
119
R50.9
ICD-10 Finland
Fever, unspecified
5.0
7.9
23
66
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.5
7.8
33
127
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
90.7
7.6
8
*
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
90.7
7.6
8
*
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
+∞
7.4
7
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
7.4
7
*
TPH07
NOMESCO Finland
Cathetrisation of artery
7.1
6.6
16
29
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.7
6.5
19
54
JLC10
NOMESCO Finland
Distal pancreatectomy
+∞
6.3
6
*
ZXD05
NOMESCO Finland
Urgent procedure
3.9
6.3
29
115
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
6.2
39
191
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
8.4
6.1
13
19
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
6.0
6.1
17
37
B01AB04
ATC
dalteparin; parenteral
10.9
6.1
11
12
WX302
NOMESCO Finland
Thoracal epidural anesthesy
13.0
6.0
10
9

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
28
43
11.19
19.40
20.2
5.1
93.85
72.93
e9/l
0.94
19
31
34
69
9.87
18.61
11.8
7.7
1.12
1.05
mmol/l
0.60
34
64
29
49
10.38
18.53
26.9
11.5
—
—
—
0
0
51
176
12.58
16.63
30.3
5.2
—
—
—
0
0
35
84
8.43
16.08
4.7
3.0
3.63
1.02
e6/l
0.86
16
36
23
36
9.65
15.35
20.9
4.6
24.48
24.83
mmol/l
0.24
23
36
52
198
11.98
15.14
6.3
4.1
526.16
23.39
e6/l
0.50
35
127
25
24
16.79
15.12
6.7
1.7
21.52
20.00
s
1.27
25
24
44
145
8.30
14.41
5.8
3.0
0.54
0.33
e6/l
0.42
34
99
25
47
8.32
14.17
23.8
9.8
1.23
1.16
mmol/l
0.14
25
47
47
168
8.83
14.06
31.6
5.1
—
—
—
0
0
44
153
7.73
13.35
11.5
4.7
7.40
7.39
ph
0.71
32
103
45
169
7.34
12.27
5.7
3.3
154.67
24.21
e6/l
0.47
35
124
28
70
6.55
11.81
29.4
8.7
104.29
104.23
mmol/l
0.02
28
70
52
240
8.88
11.63
40.4
9.3
0.16
0.00
e9/l
0.89
47
180
29
76
6.37
11.61
5.4
3.6
0.81
0.80
mmol/l
0.10
29
70
24
53
6.82
11.44
1.8
1.5
—
—
—
0
0
14
5
35.51
11.31
1.6
1.0
—
—
—
0
0
38
134
5.87
10.75
2.9
2.0
3.20
2.42
mg/l
0.76
31
117
24
57
6.29
10.54
20.1
4.3
7.38
7.40
ph
0.75
19
37
53
279
7.84
9.63
31.7
5.8
0.06
0.04
e9/l
4.52
47
238
53
279
7.84
9.63
31.7
5.8
0.91
0.56
e9/l
6.24
46
239
53
287
7.44
9.15
31.7
5.9
2.63
1.98
e9/l
1.89
47
252
34
123
4.99
8.97
9.2
1.8
1.60
1.10
mg/l
0.86
29
101
30
106
4.60
7.98
4.6
3.1
21.53
438.29
ng/l
0.79
25
73
11
6
21.90
7.93
1.1
1.0
—
—
—
0
0
19
34
7.62
7.92
20.3
13.1
93.21
93.59
%
0.07
19
34
19
47
5.42
7.76
20.2
20.4
108.16
123.26
g/l
1.91
19
47
33
132
4.27
7.32
18.9
4.8
—
—
—
0
0
18
34
7.05
7.20
19.3
12.9
10.26
9.89
mmol/l
0.06
18
34
18
34
7.05
7.20
31.8
8.9
25.06
25.04
mmol/l
0.00
18
34
12
11
13.22
7.17
1.4
2.1
—
—
—
0
0
16
27
7.63
6.89
9.3
30.9
14.39
15.45
%
0.73
16
27
23
73
4.45
6.89
3.8
3.0
—
—
—
0
0
32
130
4.07
6.85
2.4
1.6
2.14
2.54
g/l
0.33
21
73
24
80
4.30
6.73
2.6
1.6
—
—
—
0
0
38
176
4.07
6.70
15.9
2.3
—
—
—
0
0
45
235
4.49
6.67
2.7
2.0
95.48
95.38
pmol/l
0.01
28
127
18
49
4.79
6.49
1.8
1.3
—
—
—
0
0
33
142
3.88
6.41
6.0
3.4
291.50
333.70
umol/l
1.35
28
124
24
85
4.01
6.12
1.9
1.5
703.33
1069.92
nmol/l
2.18
18
67
32
141
3.67
5.89
2.6
2.1
—
—
—
0
0
28
114
3.69
5.79
2.4
1.9
—
—
—
0
0
19
60
4.15
5.62
20.4
16.7
-0.19
0.58
mmol/l
0.25
19
47
16
36
5.64
5.57
2.5
3.6
—
—
—
0
0
46
268
3.91
5.30
20.5
3.1
325.11
80.47
ug/l
1.18
46
248
8
7
12.89
4.94
1.1
1.3
—
—
—
0
0
10
14
8.29
4.87
21.8
4.1
66.55
58.42
%
—
10
14
9
11
9.36
4.74
1.0
1.4
—
—
—
0
0
16
53
3.74
4.35
1.7
1.2
—
—
—
0
0
43
259
3.24
4.31
14.5
3.0
—
—
estimate
—
0
0
18
66
3.45
4.20
1.9
1.2
—
—
—
0
0
7
7
11.08
4.12
1.1
1.1
—
—
—
0
0
11
26
4.92
3.73
1.3
1.2
—
—
—
0
0
18
71
3.18
3.71
1.6
1.4
320.00
848.57
titre
—
6
14
7
9
8.60
3.66
2.0
1.4
—
—
—
0
0
7
9
8.60
3.66
2.0
1.4
—
—
—
0
0
7
9
8.60
3.66
2.0
1.4
—
—
—
0
0
7
9
8.60
3.66
2.0
1.4
—
—
—
0
0
7
9
8.60
3.66
1.0
1.3
—
—
—
0
0
8
13
6.89
3.63
2.6
3.2
5.48
8.93
u/ml
—
8
13
8
14
6.39
3.47
26.1
2.4
61.63
54.79
%
—
8
14
6
7
9.33
3.34
1.0
1.0
—
—
—
0
0
8
15
5.96
3.31
1.0
1.3
—
—
—
0
0
7
11
7.02
3.28
1.0
1.3
—
—
—
0
0
36
217
2.61
3.27
3.6
2.0
—
—
—
0
0
8
16
5.58
3.17
1.4
1.1
—
—
—
0
0
10
27
4.22
3.04
1.3
1.1
—
—
—
0
0
8
17
5.24
3.03
1.3
1.5
—
—
—
0
0
5
5
10.72
3.03
1.4
1.4
—
—
—
0
0
10
28
4.06
2.94
21.1
2.7
0.79
0.66
%
—
10
28
6
9
7.24
2.94
1.3
1.0
—
—
—
0
0
7
14
5.49
2.81
2.0
2.4
—
—
—
0
0
5
6
8.93
2.80
1.0
1.0
—
—
—
0
0
5
6
8.93
2.80
14.0
13.3
10.58
12.53
mg/l
—
5
6
5
6
8.93
2.80
1.2
1.0
—
—
—
0
0
5
6
8.93
2.80
1.2
1.0
—
—
—
0
0
15
64
2.78
2.64
2.1
2.2
—
—
—
0
0
6
11
5.91
2.61
1.3
1.7
—
—
—
0
0
5
7
7.64
2.59
2.0
2.0
—
—
—
0
0
5
7
7.64
2.59
2.8
2.7
—
—
—
0
0
7
16
4.79
2.55
1.6
1.1
—
—
—
0
0
16
72
2.66
2.55
1.4
1.2
—
—
—
0
0
29
173
2.29
2.52
4.2
3.1
62.44
93.78
mg/l
0.27
21
113
9
28
3.59
2.42
23.3
2.7
0.88
1.22
%
—
9
28
48
363
2.51
2.28
7.4
4.6
—
349.00
—
0
10
5
9
5.93
2.25
15.8
2.2
9.74
8.89
%
—
5
9
25
146
2.21
2.24
6.0
2.6
96.56
50.42
u/l
0.84
25
132
28
173
2.14
2.17
4.8
3.5
16.07
15.78
mg/mmol
0.01
20
113
6
15
4.31
2.09
2.5
1.5
1.22
1.18
g/l
—
6
15
6
15
4.31
2.09
2.0
1.2
—
—
—
0
0
6
15
4.31
2.09
2.5
1.4
0.18
0.23
g/l
—
6
15
34
230
2.08
2.04
3.0
3.3
6.35
6.38
ph
—
10
121
6
16
4.04
1.99
1.3
1.2
—
—
—
0
0
14
67
2.41
1.94
2.2
1.9
—
—
—
0
0
7
23
3.30
1.86
1.3
1.2
—
—
—
0
0
11
200
0.45
1.58
3.5
3.0
—
—
—
0
0
6
22
2.91
1.47
1.5
1.8
—
—
—
0
0
11
56
2.18
1.32
2.0
1.8
—
—
—
0
0
54
471
2.27
1.31
4.2
4.3
1.27
1.26
mmol/l
0.03
49
430
56
500
2.46
1.29
5.8
4.8
5.66
5.86
mmol/l
0.68
51
455
23
157
1.75
1.20
1.8
2.2
126.83
182.52
u/l
0.55
23
147
24
167
1.72
1.17
1.9
1.5
—
—
—
0
0
56
503
2.38
1.15
5.9
5.6
2.47
2.63
mmol/l
0.70
51
463
55
495
2.13
1.08
4.9
4.9
1.35
1.48
mmol/l
1.43
50
455
23
162
1.67
1.06
4.4
2.5
—
—
—
0
0
6
31
2.03
0.87
6.3
7.9
0.00
0.20
%
—
6
10
6
32
1.97
0.84
6.5
7.8
0.08
0.73
%
—
6
11
0
24
0.00
0.81
0.0
1.3
—
—
—
0
0
0
26
0.00
0.80
0.0
2.0
—
0.00
—
0
7
5
24
2.18
0.76
3.4
2.3
—
—
—
0
0
5
25
2.09
0.74
1.0
1.3
—
—
—
0
0
9
58
1.65
0.74
1.1
1.2
—
—
—
0
0
5
27
1.93
0.70
1.8
1.1
—
—
—
0
0
23
177
1.48
0.69
3.0
3.5
20.39
57.17
ng/l
1.25
18
116
5
28
1.85
0.68
6.4
8.0
0.00
0.00
%
—
5
7
5
32
1.61
0.43
7.6
8.6
0.00
0.11
%
—
5
9
0
15
0.00
0.42
0.0
1.1
—
15.17
—
0
6
0
16
0.00
0.41
0.0
1.0
—
0.71
—
0
6
0
16
0.00
0.41
0.0
16.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
6.25
—
0
7
0
18
0.00
0.40
0.0
1.0
—
1.40
—
0
7
0
18
0.00
0.40
0.0
1.0
—
2.86
—
0
11
5
36
1.42
0.39
4.4
4.0
5.18
5.25
kpa
—
5
36
10
75
1.40
0.32
1.7
1.5
—
—
—
0
0
13
105
1.30
0.27
1.2
1.2
23.80
27.88
iu/ml
—
5
35
0
11
0.00
0.21
0.0
1.8
—
0.20
—
0
6
0
11
0.00
0.21
0.0
1.3
—
8.15
—
0
11
0
10
0.00
0.21
0.0
1.8
—
10.30
—
0
10
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
7.4
—
34.08
—
0
12
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
49
468
1.24
0.20
8.8
5.7
39.81
38.81
mmol/mol
0.20
44
444
56
541
1.43
0.18
32.7
12.5
—
—
—
0
0
5
45
1.12
0.10
1.4
2.1
6.20
5.83
ph
—
5
30
11
123
0.87
0.09
8.5
5.4
—
—
—
0
0
7
64
1.11
0.08
1.4
1.1
—
—
—
0
0
14
151
0.91
0.06
3.9
3.7
—
—
—
0
0
14
144
0.96
0.00
5.1
5.5
2.04
1.81
ug/l
0.16
14
127
0
7
0.00
-0.00
0.0
71.9
—
105.57
—
0
7
0
7
0.00
-0.00
0.0
71.9
—
11.86
—
0
7
0
5
0.00
-0.00
0.0
3.8
—
1.56
—
0
5
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
96
0.93
-0.00
1.8
1.8
—
—
—
0
0
12
120
1.00
-0.00
1.7
3.9
1.01
1.02
kg/l
—
7
78
0
5
0.00
-0.00
0.0
1.2
—
221.80
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
37.67
—
0
8

Mortality – FinRegistry

↥

Association

Association between endpoint D3_HYPOSPLENISM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_HYPOSPLENISM.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: D3_HYPOSPLENISM – Hyposplenism

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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