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Abnormality of red blood cells

Endpoint Browser

R18_ABNORMALITY_RED_BLOOD_CELLS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — R71
  • Cause of death: ICD-10 — R71

2 out of 7 registries used, show all original rules.

228

4. Check minimum number of events

None

228

5. Include endpoints

None

228

6. Filter based on genotype QC (FinnGen only)

199

Control definitions (FinnGen only)

Control exclude
R18_ABNORMAL_FINDI_EXAMI_BLOOD_WO_DIAGNOSIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
R7
Name in latin
Abnormitas erythrocytorum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 199 100 99
Unadjusted period prevalence (%) 0.04 0.04 0.05
Median age at first event (years) 58.21 53.42 63.05

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
206
Matched controls
2060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R71
ICD-10 Finland
Abnormality of red blood cells
+∞
295.9
206
*
D75.1
ICD-10 Finland
Secondary polycythaemia
295.8
26.3
26
*
XW000
NOMESCO Finland
Bone marrow biopsy
10.2
24.8
30
34
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.7
12.9
33
81
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
9.4
60
265
D45
ICD-10 Finland
Polycythaemia vera
15.3
8.3
13
9
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
23.1
8.1
11
5
M10.9
ICD-10 Finland
Gout, unspecified
3.7
7.1
23
67
207
Kela drug reimbursment
Chronic arrhythmias
2.7
6.8
40
167
ZXE00
NOMESCO Finland
One hour or less
2.1
6.2
90
555

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
78
224
4.99
26.27
2.8
3.1
1.85
1.75
%
0.24
69
207
80
262
4.36
22.30
2.1
2.2
2.40
2.29
g/l
0.77
72
241
82
280
4.20
21.48
2.1
2.2
15.65
13.11
umol/l
2.15
76
262
75
247
4.20
20.53
2.0
2.2
28.88
22.20
%
2.62
68
233
59
174
4.35
18.56
3.3
3.2
80.10
69.93
e9/l
1.24
41
132
159
916
4.23
18.23
6.3
6.8
0.62
0.58
e9/l
1.51
139
794
151
842
3.97
18.14
6.6
6.8
0.78
0.66
%
2.04
141
799
159
921
4.18
17.96
6.3
6.8
0.05
0.04
e9/l
1.45
141
797
121
592
3.53
17.72
6.3
6.3
—
—
—
0
0
160
938
4.16
17.58
6.4
6.8
2.06
1.94
e9/l
0.30
144
833
150
845
3.85
17.46
6.6
6.7
2.78
2.81
%
0.05
141
804
150
848
3.83
17.29
6.7
6.7
9.11
8.79
%
0.71
140
810
152
868
3.87
17.22
6.5
6.7
28.37
27.43
%
0.45
141
835
160
946
4.10
17.17
6.8
7.0
0.20
0.19
e9/l
0.50
144
830
148
859
3.57
15.72
6.3
6.7
56.07
57.52
%
0.66
141
829
163
1021
3.86
15.00
9.5
10.4
4.20
4.11
e9/l
0.18
144
891
35
83
4.88
14.27
1.5
2.3
1.37
1.49
g/l
0.27
30
74
86
403
2.95
12.51
5.1
5.6
—
—
—
0
0
132
802
2.80
11.34
4.0
2.8
160.11
112.87
ug/l
1.96
122
750
36
105
3.94
11.17
2.0
2.5
—
—
—
0
0
64
280
2.87
10.28
2.3
1.7
1186.81
1240.59
nmol/l
0.15
49
212
141
925
2.66
9.76
6.3
6.7
13.92
12.03
umol/l
1.00
135
883
83
429
2.57
9.48
3.0
2.2
3.01
2.89
mg/l
0.14
71
381
22
50
4.81
9.33
1.6
3.8
26.36
1.88
ratio
0.46
11
30
91
499
2.48
9.08
2.2
1.7
21.36
21.91
nmol/l
0.12
79
413
122
771
2.43
8.78
2.6
2.0
93.64
95.46
pmol/l
0.16
71
391
29
92
3.50
7.89
1.6
1.5
0.20
0.33
mg/l
0.95
13
44
132
889
2.35
7.87
6.4
7.3
1.20
1.21
mmol/l
0.29
105
781
19
31
6.64
7.75
1.2
1.6
—
—
—
0
0
122
812
2.23
7.25
7.2
6.5
1.20
1.21
mmol/l
0.43
109
750
53
254
2.46
6.82
1.2
1.2
—
—
—
0
0
115
766
2.13
6.60
5.6
4.5
35.61
35.65
g/l
0.02
105
719
67
361
2.27
6.59
1.9
1.8
480.45
38235741.97
pmol/l
0.50
47
306
171
1344
2.60
6.44
9.2
7.8
82.15
78.35
u/l
0.62
160
1270
33
128
2.88
6.43
7.0
10.3
24.70
25.13
mmol/l
0.35
33
128
17
34
5.35
6.03
3.2
2.8
8.24
8.71
kpa
0.44
17
34
17
34
5.35
6.03
3.2
2.8
2.36
2.78
mmol/l
0.32
12
22
17
34
5.35
6.03
3.2
2.8
4.92
4.99
kpa
0.14
17
34
13
19
7.22
5.83
1.0
1.1
—
—
—
0
0
17
46
3.94
5.77
3.5
3.2
7.43
7.42
ph
0.16
17
46
116
805
2.01
5.64
14.4
11.9
0.01
0.00
e9/l
0.60
92
657
88
562
1.99
5.35
5.0
3.9
7.40
7.40
ph
0.17
61
389
35
154
2.53
5.33
5.0
5.7
0.00
0.11
%
1.24
11
47
36
163
2.46
5.16
4.9
5.5
0.50
0.67
%
0.22
12
56
78
488
1.96
4.96
4.7
4.1
—
—
—
0
0
34
153
2.46
4.93
4.5
5.4
0.09
0.60
%
1.66
11
47
12
21
6.00
4.83
1.2
1.2
—
—
—
0
0
112
805
1.86
4.55
18.7
11.8
1.25
1.22
inr
0.28
92
670
13
28
4.88
4.45
3.3
2.4
34.77
33.11
pg
0.66
13
28
31
142
2.39
4.32
5.8
4.1
1.20
1.22
mmol/l
1.10
24
121
135
1041
1.86
4.26
5.0
5.0
6.75
6.69
mmol/l
0.12
129
997
65
404
1.89
4.10
1.7
1.4
2.47
2.41
g/l
0.12
50
219
150
1204
1.90
4.08
3.9
3.4
63.89
49.20
u/l
1.02
140
1141
30
139
2.36
4.07
3.3
3.9
—
—
—
0
0
73
473
1.84
4.03
3.1
3.1
369.81
344.41
umol/l
1.06
64
419
13
33
4.13
3.87
2.0
2.4
—
—
—
0
0
57
346
1.90
3.83
2.6
2.9
535.71
533.03
mosm/kgh2o
0.04
48
303
38
204
2.06
3.61
1.4
1.4
—
—
—
0
0
88
619
1.74
3.60
3.7
3.2
7.79
7.93
mmol/l
0.08
67
532
11
27
4.24
3.45
4.0
3.0
4.74
5.45
e9/l
0.42
11
27
48
285
1.89
3.42
4.8
3.2
4.55
3.15
e6/l
0.23
28
140
32
165
2.11
3.37
9.2
9.4
—
—
—
0
0
14
48
3.06
3.37
1.2
1.2
—
—
—
0
0
32
166
2.10
3.32
5.7
5.9
0.00
0.19
%
—
9
48
73
498
1.72
3.28
1.4
1.4
—
—
—
0
0
82
585
1.67
3.09
4.4
3.2
15.57
155.96
e6/l
0.67
63
440
73
505
1.69
3.08
4.6
3.1
0.28
0.36
e6/l
0.32
55
364
61
402
1.74
3.07
2.4
2.5
5.24
5.41
e6/l
0.04
52
365
5
5
10.20
2.99
1.2
5.6
84.00
58.60
nmol/l
—
5
5
181
1605
2.05
2.93
5.0
4.3
1.50
1.27
mmol/l
2.74
169
1468
61
407
1.71
2.92
1.9
2.0
1.81
1.38
mg/l
0.23
49
320
75
530
1.65
2.89
3.0
3.4
0.00
0.17
estimate
0.55
24
163
89
665
1.60
2.71
5.4
3.9
53.93
82.68
e6/l
0.32
67
465
8
19
4.34
2.70
1.1
1.2
—
—
—
0
0
188
1702
2.20
2.68
20.0
15.5
26.67
24.42
mg/l
0.39
162
1392
78
569
1.60
2.60
3.5
3.3
56.36
62.40
mg/l
0.08
51
367
180
1611
1.93
2.56
7.3
6.5
38.81
39.60
mmol/mol
0.55
166
1503
81
598
1.58
2.56
4.5
4.0
8.97
10.23
mg/mmol
0.11
50
373
178
1589
1.88
2.53
6.2
5.3
1.99
1.91
mu/l
0.33
165
1467
88
668
1.55
2.44
4.2
3.9
23.12
113.68
ng/l
0.58
66
496
64
451
1.61
2.44
1.7
1.3
2.61
1.82
u/ml
0.24
20
108
38
233
1.77
2.42
1.4
1.4
285.71
424.73
titre
—
7
55
154
1329
1.63
2.39
5.0
4.3
14.72
14.80
pmol/l
0.15
140
1206
5
8
6.37
2.38
1.6
1.3
1.08
1.15
ratio
—
5
8
185
1681
1.99
2.36
6.0
5.0
1.33
1.47
mmol/l
5.13
172
1549
11
40
2.85
2.31
4.0
2.9
62.00
62.33
%
0.04
11
40
185
1684
1.97
2.30
6.1
5.2
4.44
4.59
mmol/l
1.22
173
1562
5
9
5.66
2.22
1.0
1.0
133.80
147.56
nmol/l
—
5
9
182
1652
1.87
2.22
6.1
5.0
6.10
5.97
mmol/l
0.75
157
1514
75
564
1.52
2.11
2.9
2.4
51.15
63.20
u/l
0.80
68
525
10
37
2.79
2.10
1.5
2.0
62.43
62.02
%
—
10
37
16
76
2.20
2.08
2.0
1.6
18.00
22.12
iu/l
0.25
16
61
34
211
1.73
2.08
1.4
1.4
—
—
—
0
0
12
50
2.49
2.06
1.3
1.1
—
—
—
0
0
101
811
1.48
2.06
2.7
2.8
—
—
estimate
—
0
0
94
746
1.48
2.02
2.9
3.3
6.11
6.15
ph
0.13
50
417
7
22
3.26
1.89
1.1
1.7
—
—
—
0
0
50
352
1.56
1.88
3.4
2.6
2.46
2.46
mmol/l
0.10
45
316
14
66
2.20
1.86
1.2
1.4
—
—
—
0
0
12
53
2.34
1.84
4.0
3.1
—
—
—
0
0
9
35
2.64
1.82
1.3
1.8
—
—
—
0
0
76
588
1.46
1.82
3.5
3.6
—
—
—
0
0
77
599
1.46
1.79
2.9
3.0
2.38
2.36
mmol/l
0.90
71
539
31
196
1.68
1.79
5.6
3.7
7.34
7.39
ph
2.16
16
122
185
1712
1.79
1.77
6.7
5.9
2.67
2.68
mmol/l
0.03
173
1582
6
18
3.40
1.76
1.7
1.7
—
—
—
0
0
85
677
1.44
1.73
1.9
2.1
—
—
—
0
0
113
948
1.43
1.73
3.5
3.7
0.00
0.00
estimate
-0.00
32
199
6
19
3.22
1.67
3.5
3.4
—
—
—
0
0
7
25
2.86
1.66
2.4
1.6
9.89
5.68
u/ml
—
7
25
10
42
2.45
1.64
1.2
1.7
—
—
—
0
0
10
42
2.45
1.64
1.1
1.5
3.56
3.90
mmol/l
—
10
36
5
14
3.63
1.62
1.8
1.3
—
—
—
0
0
192
1805
1.94
1.61
15.2
12.0
27.75
26.17
u/l
0.67
182
1761
19
107
1.85
1.61
3.4
4.4
—
—
—
0
0
36
248
1.55
1.49
3.3
2.5
118.10
134.94
ug/g
0.21
31
196
18
103
1.82
1.46
1.2
1.1
—
—
—
0
0
5
16
3.18
1.44
1.2
1.1
—
—
—
0
0
87
717
1.37
1.39
3.1
3.7
0.00
0.01
estimate
0.50
28
167
65
511
1.40
1.38
3.4
3.3
—
—
—
0
0
6
23
2.66
1.37
1.7
1.7
31.25
33.71
g/l
—
6
23
110
942
1.36
1.37
3.4
3.7
0.00
0.00
estimate
-0.00
30
194
30
202
1.57
1.37
1.3
1.7
—
—
—
0
0
112
963
1.36
1.36
3.6
3.7
0.00
1.63
estimate
0.50
33
184
30
203
1.56
1.34
2.0
1.6
—
—
—
0
0
28
187
1.58
1.33
5.9
3.7
0.85
1.98
mmol/l
0.54
21
156
9
43
2.14
1.32
1.1
1.1
—
—
—
0
0
36
255
1.50
1.32
7.9
7.3
103.97
104.21
mmol/l
0.11
36
255
6
24
2.54
1.31
2.3
3.7
—
—
—
0
0
6
24
2.54
1.31
1.2
2.2
—
—
—
0
0
22
139
1.65
1.29
2.3
4.6
7.38
7.34
ph
0.51
16
95
70
565
1.36
1.26
2.7
2.4
—
—
—
0
0
32
225
1.50
1.22
1.3
1.2
—
—
—
0
0
22
143
1.60
1.17
1.4
1.4
—
—
—
0
0
5
20
2.54
1.16
1.8
1.9
13.66
11.62
%
—
5
20
26
184
1.47
0.97
2.9
4.2
3.05
33.69
ug/l
0.72
20
150
14
85
1.69
0.97
3.5
4.7
—
—
—
0
0
65
538
1.30
0.96
7.9
6.7
—
—
—
0
0
87
749
1.28
0.95
2.2
1.9
1.45
1.32
mmol/l
0.71
65
627
7
37
1.92
0.95
3.3
1.8
—
—
—
0
0
6
28
2.18
0.92
1.3
1.2
—
—
—
0
0
6
28
2.18
0.92
1.8
2.1
—
—
—
0
0
184
1753
1.46
0.91
18.2
13.6
—
—
—
0
0
38
294
1.36
0.88
1.3
1.3
0.65
9.56
u/ml
—
10
113
62
516
1.29
0.88
3.5
3.7
0.00
0.02
estimate
0.50
30
179
28
208
1.40
0.83
7.3
8.6
7.41
7.42
ph
0.13
11
121
0
25
0.00
0.79
0.0
1.9
—
10.72
—
0
25
40
318
1.32
0.79
1.4
1.3
49.86
34.53
iu/ml
—
10
109
23
170
1.40
0.71
1.8
1.7
—
—
—
0
0
11
69
1.63
0.70
2.7
1.6
—
—
—
0
0
19
136
1.44
0.69
1.3
1.6
—
—
—
0
0
33
261
1.31
0.68
1.7
1.7
—
—
—
0
0
79
695
1.22
0.68
3.8
3.3
—
—
—
0
0
27
208
1.34
0.66
7.3
8.6
1.10
1.12
mmol/l
0.01
21
181
11
71
1.58
0.63
2.7
1.5
—
—
—
0
0
11
71
1.58
0.63
2.7
1.5
—
—
—
0
0
11
71
1.58
0.63
2.7
1.5
—
—
—
0
0
8
49
1.66
0.63
3.3
2.0
—
—
—
0
0
41
342
1.25
0.57
3.8
3.8
11.37
179.94
ng/l
2.31
27
267
31
250
1.28
0.57
2.4
1.9
—
—
—
0
0
9
65
1.40
0.51
3.1
1.6
—
—
—
0
0
23
181
1.30
0.50
2.0
1.6
—
—
—
0
0
21
166
1.30
0.45
1.2
1.2
—
—
—
0
0
46
400
1.19
0.44
3.3
3.7
1.02
1.02
kg/l
0.19
33
258
8
57
1.42
0.42
1.9
1.5
—
—
—
0
0
5
32
1.58
0.42
2.8
2.8
6.26
9.05
pmol/l
—
5
32
11
79
1.41
0.41
1.8
1.8
0.00
0.00
estimate
—
5
26
11
79
1.41
0.41
8.2
4.2
36.81
36.99
°c
0.58
11
79
12
160
0.73
0.41
2.6
2.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
13
99
1.33
0.36
5.4
3.6
4.12
4.55
pmol/l
0.78
13
88
57
519
1.14
0.31
3.1
3.0
—
0.17
—
0
12
7
57
1.24
0.29
1.3
1.2
—
—
—
0
0
14
170
0.81
0.26
1.9
2.2
6.29
6.17
ph
—
7
114
9
72
1.26
0.26
1.4
1.8
—
—
—
0
0
6
83
0.71
0.24
1.2
1.3
—
—
—
0
0
10
125
0.79
0.23
2.7
3.3
—
—
—
0
0
11
88
1.26
0.23
3.4
2.5
—
—
—
0
0
5
40
1.26
0.22
2.4
5.9
—
—
—
0
0
5
41
1.22
0.22
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
6.9
—
6.70
—
0
12
0
12
0.00
0.21
0.0
1.3
—
7.15
—
0
12
0
14
0.00
0.20
0.0
3.4
—
43.00
—
0
6
6
50
1.21
0.20
1.0
1.1
—
—
—
0
0
14
118
1.20
0.19
1.1
1.2
—
—
—
0
0
6
52
1.16
0.19
1.0
1.3
—
—
—
0
0
40
370
1.10
0.17
3.3
3.0
0.65
0.81
ug/l
0.71
26
219
7
63
1.11
0.17
13.4
8.3
—
—
—
0
0
12
101
1.20
0.17
1.2
1.1
—
—
—
0
0
9
78
1.16
0.15
1.6
2.0
—
—
—
0
0
63
604
1.06
0.12
5.7
4.6
1.40
2.03
ug/l
1.40
54
535
11
96
1.15
0.10
1.2
1.2
—
—
—
0
0
14
153
0.91
0.07
1.4
1.4
—
—
—
0
0
35
336
1.05
0.06
2.0
2.1
—
—
—
0
0
21
198
1.07
0.05
1.3
1.5
—
—
—
0
0
16
153
1.05
0.01
1.8
1.9
0.00
0.00
estimate
—
5
32
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
348.01
—
0
8
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.4
—
48.33
—
0
9
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.3
—
0.33
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: R18_ABNORMALITY_RED_BLOOD_CELLS – Abnormality of red blood cells

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).