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Secondary polycythaemia

DOID EFO Endpoint Browser PheWeb

D3_SCNDPOLYCYTHAEMIA

polycythemia: Abnormally high mass or concentration of red blood cells in the blood, either due to an increase in erythropoiesis or a decrease in plasma volume.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D75.1
  • Hospital discharge: ICD-9 — 2890
  • Hospital discharge: ICD-8 — 28900
  • Cause of death: ICD-10 — D75.1
  • Cause of death: ICD-9 — 2890
  • Cause of death: ICD-8 — 28900

2 out of 7 registries used, show all original rules.

950

4. Check minimum number of events

None

950

5. Include endpoints

None

950

6. Filter based on genotype QC (FinnGen only)

921

Control definitions (FinnGen only)

Control exclude
D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D75
Name in latin
Polycythaemia secundaria

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5793 1925 3795
Only index persons 4662 1564 3098
Unadjusted period prevalence (%)
Whole population 0.09 0.06 0.11
Only index persons 0.10 0.06 0.12
Median age at first event (years)
Whole population 58.75 60.79 57.65
Only index persons 57.47 60.07 56.16

-FinnGen-

Key figures

All Female Male
Number of individuals 921 326 595
Unadjusted period prevalence (%) 0.22 0.12 0.27
Median age at first event (years) 58.55 57.35 59.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
950
Matched controls
9500
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D75.1
ICD-10 Finland
Secondary polycythaemia
16384.0
307.7
886
5
D45
ICD-10 Finland
Polycythaemia vera
75.8
242.4
131
20
XW000
NOMESCO Finland
Bone marrow biopsy
11.3
121.9
136
138
SPAT1074
SPAT
Venesection
38.1
86.9
54
15
TPH00
NOMESCO Finland
Phlebotomy
80.1
53.7
60
8
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
4.6
53.5
143
356
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
524.8
50.9
50
*
D75.0
ICD-10 Finland
Familial erythrocytosis
513.7
49.9
49
*
28900
ICD-8 Finland
Other disease of blood and blood-forming organs, Polycythaemia, secondary
+∞
48.3
46
*
G47.3
ICD-10 Finland
Sleep apnoea
2.8
47.7
363
1732
T90
ICPC
Diabetes non-insulin dependent
2.8
46.2
348
1647
103
Kela drug reimbursment
Diabetes, insulin-treated
2.7
45.4
372
1834
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.7
44.8
340
1610
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.7
44.8
347
1661
A10BA02
ATC
metformin; oral
2.6
43.1
383
1955
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
17.3
42.0
35
21
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
9.3
39.2
48
54
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
35.1
191
749
L01XX05
ATC
hydroxycarbamide; oral
12.6
34.3
34
28
SPAT1262
SPAT
Handing over of treatment supplies
2.7
33.1
227
1002
E29.1
ICD-10 Finland
Testicular hypofunction
7.2
32.9
50
73
R71
ICD-10 Finland
Abnormality of red blood cells
50.7
32.7
39
8
C03CA01
ATC
furosemide; systemic
2.3
30.9
343
1878
J96.1
ICD-10 Finland
Chronic respiratory failure
5.7
27.2
52
96
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.7
26.4
158
646
C01AA05
ATC
digoxin; systemic
3.3
25.9
107
355
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
25.7
520
3520
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.4
25.6
212
1011
A10BH01
ATC
sitagliptin; oral
2.8
24.5
137
539
I50.9
ICD-10 Finland
Heart failure, unspecified
2.5
24.1
177
797
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.2
24.1
100
332
R5140
NOMESCO Finland
Monitoring the use of the aid
2.5
23.5
167
740
A10BJ06
ATC
semaglutide; parenteral
3.3
23.2
92
297
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.1
22.4
284
1604
C07AB07
ATC
bisoprolol; oral
1.9
22.1
508
3525
I10
ICD-10 Finland
Essential (primary) hypertension
2.0
21.8
635
4768
D75.2
ICD-10 Finland
Essential thrombocytosis
117.7
21.7
23
*
205
Kela drug reimbursment
Chronic hypertension
2.0
21.2
289
1671
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
20.7
118
468
E66.8
ICD-10 Finland
Other obesity
3.5
20.6
73
219
B99
ICPC
Blood/lymph/spleen disease other
42.7
20.5
25
6
C03DA01
ATC
spironolactone; oral
2.4
20.4
154
699
207
Kela drug reimbursment
Chronic arrhythmias
2.3
20.3
185
912
C07AB02
ATC
metoprolol; systemic
2.2
20.0
214
1126
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.1
19.9
88
303
A10AE04
ATC
insulin glargine; parenteral
2.5
19.4
131
564
M04AA01
ATC
allopurinol; systemic
2.3
19.2
159
751
R03BB04
ATC
tiotropium bromide; inhalant
2.5
19.0
130
563
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
56.2
19.0
22
*
A10BK03
ATC
empagliflozin; oral
2.4
18.4
141
644
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.0
18.1
233
1309
SPAT1249
SPAT
Treatment-related counselling outside office
1.9
18.1
366
2393
C08CA01
ATC
amlodipine; oral
1.8
17.9
402
2713
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
5.1
17.5
37
75
E66.00
ICD-10 Finland
Metabolic syndrome
3.0
17.3
81
288
R06.0
ICD-10 Finland
Dyspnoea
1.9
17.2
288
1765
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
15.1
17.2
28
19
A10BK01
ATC
dapagliflozin; oral
2.6
16.8
107
447
E66.01
ICD-10 Finland
Obesity due to excess calories
2.5
16.4
108
458
TPH00, ,
SPAT
40.8
16.4
20
5
XG466
NOMESCO Finland
Sleep oxymetry
3.6
16.0
53
152
N06AX12
ATC
bupropion; oral
2.8
16.0
86
330
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.2
15.7
155
784
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.5
15.7
54
159
D58.2
ICD-10 Finland
Other haemoglobinopathies
+∞
15.7
15
*
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
6.6
15.4
25
39
121
Kela drug reimbursment
Severe hypofunction of sexual glands
5.3
15.4
31
60
B01AA03
ATC
warfarin; systemic
2.0
15.3
197
1100
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.0
14.9
67
233
R03AC02
ATC
salbutamol; inhalant
1.7
14.4
512
3862
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.3
14.4
124
593
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.8
14.3
72
267
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.8
14.2
253
1567
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.0
14.0
175
964
201
Kela drug reimbursment
Chronic cardiac insufficiency
2.8
13.6
70
262
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.3
13.3
50
156
N02AX02
ATC
tramadol; systemic, rectal
1.7
12.9
428
3139
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.8
12.9
65
241
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
12.8
194
1139
I50.0
ICD-10 Finland
Congestive heart failure
2.5
12.8
85
362
OAB50, ,
SPAT
2.3
12.7
98
447
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
6.1
12.6
22
37
C09AA02
ATC
enalapril; systemic
1.9
12.6
196
1159
2890X
ICD-9 Finland
Other diseases of blood and blood-forming organs, Polycythaemia, secondary[ERYTHROCYTOSIS SECUNDARIA, NUD]
+∞
12.5
12
*
E66.9
ICD-10 Finland
Obesity, unspecified
3.4
12.5
44
132
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.4
12.4
86
373
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.3
12.3
46
143
WX723
NOMESCO Finland
CPAP therapy
2.8
12.3
65
247
I48.1
ICD-10 Finland
Persistent atrial fibrillation
3.0
12.2
56
197
A10BJ02
ATC
liraglutide; parenteral
3.4
12.2
43
129
C02AC05
ATC
moxonidine; oral
2.8
11.9
62
234
H02AB06
ATC
prednisolone; systemic
1.6
11.8
446
3354
WX780
NOMESCO Finland
Remote monitoring CPAP
2.7
11.6
65
255
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
11.6
189
1133
N06AX11
ATC
mirtazapine; oral
1.7
11.5
316
2191
Y28
ICPC
Limited function/disability (Y)
13.8
11.5
19
14
SPAT1377
SPAT
Polysomnography
3.3
11.3
43
135
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.0
11.3
127
671
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.7
11.2
60
230
A10AB05
ATC
insulin aspart; parenteral
2.3
11.1
88
405
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
43.8
10.9
13
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
10.9
177
1059
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
10.7
177
1062
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
10.4
212
1354
ZXE00
NOMESCO Finland
One hour or less
1.6
10.1
341
2471
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
3.2
10.1
39
124
A02BC02
ATC
pantoprazole; systemic
1.6
10.1
633
5285
SPAT1260
SPAT
Consultation of another employee
1.8
10.0
158
935
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.9
9.8
132
742
M10.9
ICD-10 Finland
Gout, unspecified
2.2
9.8
82
387
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
9.8
312
2229
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
9.8
122
669
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
9.2
9.5
19
21
E83.1
ICD-10 Finland
Disorders of iron metabolism
10.2
9.5
18
18
SPAT1263
SPAT
Sampling
1.6
9.5
360
2671
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.8
9.5
146
856
TFP20
NOMESCO Finland
Cardiodefibrillation
2.2
9.5
83
399
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
9.4
271
1885
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
2.7
9.4
50
191
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
3.8
9.4
28
75
J45.8
ICD-10 Finland
Mixed asthma
3.4
9.4
33
99
C09AA05
ATC
ramipril; oral
1.6
9.3
249
1703
L28
ICPC
Limited function/disability (L)
1.8
9.2
167
1029
I48.2
ICD-10 Finland
Chronic atrial fibrillation
2.5
9.1
55
224
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
9.1
255
1761
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
37.1
9.0
11
*
N06AB10
ATC
escitalopram; oral
1.7
8.9
175
1103
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
8.8
165
1024
C09CA01
ATC
losartan; oral
1.6
8.8
248
1714
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.8
8.8
136
799
R53
ICD-10 Finland
Malaise and fatigue
1.6
8.8
227
1536
N07BA03
ATC
varenicline; oral
2.5
8.7
56
235
Z72.0
ICD-10 Finland
Tobacco use
3.1
8.7
36
120
I42.0
ICD-10 Finland
Dilated cardiomyopathy
3.1
8.7
36
120
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.1
8.7
87
441
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.1
8.6
79
386
C10AA01
ATC
simvastatin; oral
1.5
8.6
382
2918
I50.1
ICD-10 Finland
Left ventricular failure
2.5
8.5
54
225
D70.82
ICD-10 Finland
Drug-induced neutropenia
90.8
8.4
9
*
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
12.9
8.4
14
11
Q21.81
ICD-10 Finland
Eisenmenger's syndrome
+∞
8.3
8
*
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.2
8.3
32
102
SPAT1281
SPAT
Other administrative function
2.1
8.1
74
362
JN3AD
NOMESCO Finland
Abdominal CT examination
1.8
8.0
128
758
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.5
8.0
27
79
C08CA02
ATC
felodipine; oral
2.0
7.9
89
470
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
7.9
110
624
A10BB12
ATC
glimepiride; oral
2.2
7.9
69
332
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
7.7
352
2688
M54.5
ICD-10 Finland
Low back pain
1.5
7.7
324
2434
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.6
7.7
219
1510
N06AB06
ATC
sertraline; oral
1.9
7.7
100
555
I50
ICD-10 Finland
Heart failure
3.0
7.6
33
113
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
3.9
7.6
22
58
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
2.8
7.5
37
136
R03BA05
ATC
fluticasone; inhalant
1.7
7.4
155
990
212
Kela drug reimbursment
Gout
3.8
7.4
22
59
M10
ICD-10 Finland
Gout
2.4
7.4
51
222
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
3.0
7.3
32
110
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
9.5
7.3
14
15
XFE00
NOMESCO Finland
Epicardial ultrasonography
3.3
7.3
27
84
A10BH02
ATC
vildagliptin; oral
3.4
7.3
25
74
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.9
7.3
95
528
J01AA02
ATC
doxycycline; systemic
1.5
7.2
702
6184
A10BJ01
ATC
exenatide; parenteral
4.5
7.2
17
38
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
7.2
109
635
H02AB09
ATC
hydrocortisone; systemic
3.3
7.1
26
80
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.3
7.1
26
80
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
7.1
123
745
T82
ICPC
Obesity
2.5
7.1
42
170
WZC00, ,
SPAT
1.7
7.1
131
809
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
7.1
185
1249
B04
ICPC
Blood symptom/complaint
10.1
7.0
13
13
SPAT1254
SPAT
Administration of medicine
1.7
7.0
124
755
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
7.0
125
763
A12BA01
ATC
potassium chloride; oral
2.6
7.0
39
153
K99
ICPC
Cardiovascular disease other
3.1
7.0
29
97
GX2D5
NOMESCO Finland
Sleep oximetry
7.6
6.9
15
20
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.9
342
2644
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
6.8
172
1150
C03AA03
ATC
hydrochlorothiazide; oral
2.0
6.8
77
408
R95
ICPC
Chron obstructive pulmonary disease
2.7
6.8
35
132
J01DB01
ATC
cefalexin; oral
1.5
6.8
746
6687
OAB75, ,
SPAT
3.1
6.8
27
88
D75.8
ICD-10 Finland
Other specified diseases of blood and blood-forming organs
40.3
6.8
8
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
6.8
634
5503
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
3.3
6.7
24
73
H03AA01
ATC
levothyroxine sodium; systemic
1.6
6.6
169
1133
N05BA04
ATC
oxazepam; oral
1.5
6.6
222
1584
G04CA02
ATC
tamsulosin; oral
1.5
6.6
249
1820
SPAT1310
SPAT
Counselling related to known health issue
1.5
6.6
259
1909
N05CF02
ATC
zolpidem; oral
1.6
6.6
149
970
C09DA01
ATC
losartan and diuretics; oral
1.8
6.5
101
594
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.3
6.4
45
197
ZXD05
NOMESCO Finland
Urgent procedure
1.5
6.4
255
1881
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
6.4
160
1066
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.8
6.4
97
565
Z02.7
ICD-10 Finland
Issue of medical certificate
2.0
6.3
70
368
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.1
6.3
61
305
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
6.3
234
1703
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.8
6.3
88
501
A10AE05
ATC
insulin detemir; parenteral
2.2
6.3
53
252
D70.89
ICD-10 Finland
Neutropenic splenomegaly
26.9
6.2
8
*
S01
ICPC
Pain/tenderness of skin
2.3
6.2
44
194
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.5
6.2
38
157
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.9
6.2
83
466
R52.9
ICD-10 Finland
Pain, unspecified
1.8
6.2
92
534
160
Kela drug reimbursment
exenatide
3.0
6.1
26
88
JAF30
NOMESCO Finland
Repair of umbilical hernia using prosthetic material
2.9
6.1
28
99
B01AB05
ATC
enoxaparin; parenteral
1.5
6.1
264
1979
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
6.1
454
3753
N05AH04
ATC
quetiapine; oral
1.6
6.1
158
1064

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Secondary polycythaemia
D75.1 (45532998)
Hemoglobin electrophoresis panel in Blood
43113-0 (3032868)
Essential thrombocytosis
D75.2 (45557096)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Disease of blood and blood-forming organs, unspecified
D75.9 (45576417)
Venesection
SPAT1074 (2001700175)
Familial erythrocytosis
D75.0 (45576416)
Phlebotomy
TPH00 (2001309596)
SMOKING - SMOKE2: no - SMOKE3: former - SMOKE5: Unspecified
SMOKING-2-2-0 (2002330110)
SMOKING - SMOKE2: no - SMOKE3: never - SMOKE5: Unspecified
SMOKING-2-3-0 (2002330113)
SMOKING - SMOKE2: yes - SMOKE3: current - SMOKE5: Unspecified
SMOKING-1-1-0 (2002330116)
JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
80187-8 (21494670)
Erythropoietin (EPO) [Units/volume] in Serum or Plasma
15061-5 (3024172)
Hypothyroidism, unspecified
E03.9 (45537945)
Abnormality of red blood cells
R71 (45573038)
Other disease of blood and blood-forming organs, Polycythaemia, secondary
28900 (2000301664)
Other diseases of blood and blood-forming organs, Polycythaemia, secondary[ERYTHROCYTOSIS SECUNDARIA, NUD]
2890X (2000402710)
Hypogonadotropic hypogonadism
E23.04 (2000501472)
Metabolic syndrome
E66.00 (2000501500)
Ultrasound examination of upper part of abdomen
JN1AE (2001305517)
Abdominal ultrasound examination
JN3AE (2001305555)
Bone marrow biopsy
XW000 (2001310618)
CPAP therapy
WX723 (2001310826)
Diabetes, non-insulin-treated
215 (2001600211)
Karyotype in Bone marrow
81861-7 (21494434)
Ferritin [Mass/volume] in Serum or Plasma
2276-4 (3001122)
Gas panel - Arterial blood
24336-0 (3019060)
Reticulocytes [#/volume] in Blood
14196-0 (3023520)
Reticulocytes/Erythrocytes in Blood
4679-7 (3027945)
Morphology [Interpretation] in Bone marrow Narrative
51628-6 (3042111)
Supplier / Service Provider
OMOP5117446 (33004)
Hematology
82 (38004501)
Short blood count panel - Blood
55429-5 (40758558)
Hyperplasia of prostate
N40 (45563015)
Testicular hypofunction
E29.1 (45576454)
Other specified chronic obstructive pulmonary disease
J44.8 (45586673)
Polycythaemia vera
D45 (45595761)
androstanolone
G03BB02 (21602513)
androstanolone
A14AA01 (21600917)
Internal Medicine
11 (38004456)
testosterone; oral, parenteral, rectal, sublingual, transdermal
G03BA03 (21602510)
Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
14804-9 (3022250)
Normoblasts [#/volume] in Blood
715-3 (3021589)
Sleep apnoea
G47.3 (45562094)
Neutrophils [#/volume] in Blood by Automated count
751-8 (3013650)
Iron/Transferrin [Ratio] in Serum or Plasma
60517-0 (40763571)
Microorganisms panel - Urine sediment
58435-9 (40761536)
dapagliflozin; oral
A10BK01 (1123890)
Transferrin [Mass/volume] in Serum or Plasma
3034-6 (3004789)
Outpatient Visit
OP (9202)
Iron [Moles/volume] in Serum or Plasma
14798-3 (3022948)
hydroxycarbamide; oral
L01XX05 (21603787)
CBC W Ordered Manual Differential panel - Blood
57782-5 (40760892)
empagliflozin; oral
A10BK03 (1123740)
Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
13317-3 (3019902)
Testosterone [Moles/volume] in Serum or Plasma
14913-8 (3017446)
tibolone; oral
G03CX01 (21602536)
pH of Capillary blood
2745-8 (3009343)
Carbon dioxide [Partial pressure] in Capillary blood
2020-6 (3023024)
Cardiology
6 (38004451)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
Differential panel, method unspecified - Blood
69738-3 (42870588)
Monocytes [#/volume] in Blood
26484-6 (3001604)
Basophils [#/volume] in Blood
26444-0 (3006315)
Monocytes/Leukocytes in Blood
26485-3 (3019069)
Emergency Room Visit
ER (9203)
Eosinophils/Leukocytes in Blood
26450-7 (3006504)
Eosinophils [#/volume] in Blood
26449-9 (3013115)
Basophils/Leukocytes in Blood
30180-4 (3022096)
Base excess in Blood by calculation
11555-0 (3012501)
Carbon dioxide [Partial pressure] in Blood
11557-6 (3013290)
Oxygen [Partial pressure] in Blood
11556-8 (3027315)
Other specified special examinations
Z01.8 (45581003)
Lymphocytes/Leukocytes in Blood
26478-8 (3002030)
Lymphocytes [#/volume] in Blood
26474-7 (3019198)
Metamyelocytes/Leukocytes in Blood
28541-1 (3002179)
Platelets [#/volume] in Blood
26515-7 (3007461)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
MCH [Entitic mass]
28539-5 (3035941)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
Calcium.ionized [Moles/volume] in Serum or Plasma
1995-0 (3021347)
Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M
62238-1 (40764999)
Neutrophils/Leukocytes in Blood
26511-6 (3018010)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
19072-8 (3016431)
Blasts/Leukocytes in Blood
26446-5 (3025159)
digoxin; oral, parenteral
C01AA05 (21600234)
Dyspnoea
R06.0 (45558449)
Urate [Moles/volume] in Serum or Plasma
14933-6 (3026493)
Promyelocytes/Leukocytes in Blood
26524-9 (3021440)
Myelocytes/Leukocytes in Blood
26498-6 (3017181)
INR in Blood by Coagulation assay
34714-6 (3032080)
Pulmonary Disease
29 (38004472)
CBC panel - Blood by Automated count
58410-2 (40761511)
Forced vital capacity [Volume] Respiratory system --post bronchodilation
19875-4 (3001668)
FEV1 --post bronchodilation
20155-8 (3023550)
FEV1/FVC --post bronchodilation
69970-2 (42868459)
FVC percent change Respiratory system
69982-7 (42868471)
FEV1 percent change
69983-5 (42868472)
pH of Blood
11558-4 (3010421)
FEV1/FVC
19926-5 (3011505)
Forced vital capacity [Volume] Respiratory system
19870-5 (3020158)
FEV1
20150-9 (3024653)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
Gas panel - Central venous blood
97535-9 (1616796)
Testosterone Free [Moles/volume] in Serum or Plasma by calculation
96559-0 (36032269)
Epithelial cells [#/volume] in Urine
30383-4 (3000850)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1742-6 (3006923)
Laboratory Visit
OMOP4822461 (32036)
tadalafil; oral
G04BE08 (21602653)
Lutropin [Units/volume] in Serum or Plasma
10501-5 (3009214)
Bilirubin.total [Moles/volume] in Serum or Plasma
14631-6 (3006140)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)
Atrial fibrillation and flutter
I48 (45596206)
pH of Serum or Plasma
2753-2 (3018418)
Diabetes non-insulin dependent
T90 (2002001131)
tiotropium bromide; inhalant
R03BB04 (21603296)
Case Management Agency
251B00000X (38004193)
Remote monitoring CPAP
WX780 (2001310837)
Bacteria [Presence] in Urine
87829-8 (36304419)
Handing over of treatment supplies
SPAT1262 (2001700363)
Albumin [Presence] in Urine by Test strip
50949-7 (3029937)
Thorax X-ray examination
GD1AA (2001303617)
Type 2 diabetes mellitus, without complications
E11.9 (45561952)
spironolactone; oral
C03DA01 (21601534)
Endocrinology
46 (38004485)
Sex hormone binding globulin [Moles/volume] in Serum or Plasma
13967-5 (3004248)
Oxygen [Partial pressure] in Capillary blood
2704-5 (3028626)
Bicarbonate [Moles/volume] in Serum or Plasma
1963-8 (3016293)
Type 2 diabetes mellitus
E11 (45571656)
Chronic respiratory failure
J96.1 (45557632)
Asthma, unspecified
J45.9 (45562456)
bisoprolol; oral
C07AB07 (21601689)
Casts [#/volume] in Urine by Automated count
51483-6 (3030467)
furosemide; oral, parenteral
C03CA01 (21601518)
Pharmacy visit
OMOP4822462 (581458)
Extreme obesity with alveolar hypoventilation
E66.2 (45581373)
Psychiatry
26 (38004469)
Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
30248-9 (3015399)
semaglutide; oral, parenteral
A10BJ06 (1501778)
Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
6768-6 (3035995)
warfarin; oral, parenteral
B01AA03 (21600965)
Glucose [Moles/volume] in Serum or Plasma
14749-6 (3013826)
Extensive CT examination of arteria pulmonalis
FB1BD (2001302407)
Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method
4537-7 (3013707)
Neurology
13 (38004458)
Treatment-related counselling outside office
SPAT1249 (2001700350)
Leukocytes [#/volume] in Urine
30405-5 (3018095)
Prothrombin time (PT) actual/Normal
5894-1 (3033658)
Overnight pulse oximetry
252568001 (4091874)
12 lead EKG panel
34534-8 (3044889)
Oxygen saturation in Capillary blood
2709-4 (3021901)
Base excess in Arterial blood by calculation
1925-7 (3003396)
Albumin [Mass/volume] in Urine
1754-1 (3012516)
Leukocyte esterase [Presence] in Urine by Automated test strip
60026-2 (40763086)
Essential (primary) hypertension
I10 (45591453)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1920-8 (3013721)
Thyroxine (T4) free [Moles/volume] in Serum or Plasma
14920-3 (3008486)
Creatinine [Moles/volume] in Urine
14683-7 (3009508)
salbutamol; inhalant
R03AC02 (21603256)
One hour or less
ZXE00 (2001311394)
Lipid panel - Serum or Plasma
100898-6 (1761868)
Ketones [Presence] in Urine by Test strip
2514-8 (3035350)
Monitoring the use of the aid
R5140 (2001310249)
Glucose [Presence] in Urine by Test strip
25428-4 (3009261)
Comprehensive monitoring of chronic illness
SPAT1250 (2001700351)
Albumin/Creatinine [Ratio] in Urine
32294-1 (3020682)
amlodipine; oral
C08CA01 (21601747)
Other administrative function
SPAT1281 (2001700382)
Hemoglobin A1c/Hemoglobin.total in Blood
4548-4 (3004410)
Inpatient Hospital
21 (8717)
Thyrotropin [Units/volume] in Serum or Plasma
3016-3 (3009201)
metoprolol; oral, parenteral
C07AB02 (21601684)
Outpatient Hospital
22 (8756)
Cholesterol in HDL [Moles/volume] in Serum or Plasma
14646-4 (3023602)
Inpatient Visit
IP (9201)
Cholesterol [Moles/volume] in Serum or Plasma
14647-2 (3019900)
Triglyceride [Moles/volume] in Serum or Plasma --fasting
47210-0 (3048773)
Cholesterol in LDL [Moles/volume] in Serum or Plasma
22748-8 (3001308)
metformin; oral
A10BA02 (21600747)
Fasting glucose [Moles/volume] in Serum or Plasma
14771-0 (3018251)
tramadol; oral, parenteral, rectal
N02AX02 (21604298)
paracetamol; oral, parenteral, rectal
N02BE01 (21604344)
pantoprazole; oral, parenteral
A02BC02 (21600097)
cefalexin; oral
J01DB01 (21602870)
codeine and paracetamol
N02AJ06 (1123647)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
505
139
76.43
307.65
1.4
1.3
14.69
45.38
u/l
1.31
450
120
110
106
11.61
101.74
1.1
1.9
—
—
—
0
0
356
1208
4.11
91.31
2.5
2.8
25.38
23.27
%
1.98
331
1134
364
1292
3.95
86.90
2.5
2.7
2.55
2.29
g/l
15.44
338
1202
724
4152
4.13
80.71
7.2
6.3
0.05
0.04
e9/l
12.55
655
3565
372
1398
3.73
80.64
2.7
2.7
15.57
13.29
umol/l
6.04
347
1307
719
4139
4.03
78.85
7.3
6.3
0.65
0.60
e9/l
7.64
651
3553
725
4221
4.03
77.57
7.2
6.4
2.07
1.97
e9/l
0.68
676
3726
727
4274
3.99
75.84
7.6
6.6
0.21
0.20
e9/l
2.18
672
3742
550
2734
3.40
74.84
7.1
6.2
—
—
—
0
0
669
3812
3.55
71.36
7.7
6.6
0.78
0.68
%
4.14
641
3572
668
3809
3.54
71.03
7.6
6.5
2.78
2.90
%
0.70
641
3574
667
3812
3.52
70.39
7.7
6.6
8.71
9.01
%
2.41
639
3581
672
3889
3.49
68.79
7.7
6.5
26.27
27.13
%
1.36
648
3696
73
9
87.85
66.02
1.3
1.4
—
—
—
0
0
655
3828
3.29
63.93
7.4
6.4
58.23
57.67
%
0.66
632
3661
733
4603
3.59
62.92
10.9
9.8
4.63
4.18
e9/l
5.43
659
4003
264
942
3.50
59.62
2.3
2.7
1.78
1.80
%
0.10
235
851
65
72
9.62
53.93
1.1
1.4
—
—
—
0
0
377
1815
2.79
48.91
5.0
4.8
—
—
—
0
0
96
194
5.39
45.80
4.2
3.9
—
—
—
0
0
204
722
3.32
45.58
2.5
2.7
93.00
69.47
e9/l
11.72
156
532
85
162
5.66
43.19
5.8
4.7
3.32
2.59
mmol/l
0.86
60
109
484
2805
2.48
40.91
4.2
3.6
66.68
53.51
mg/l
0.47
347
1871
490
2859
2.47
40.77
5.4
4.3
11.72
9.39
mg/mmol
0.52
333
1845
409
2237
2.45
38.73
3.3
2.8
372.25
355.04
umol/l
2.72
365
1984
566
3584
2.43
38.43
16.9
11.5
0.00
0.00
e9/l
0.56
486
2954
494
2974
2.38
37.23
4.2
3.5
7.98
8.09
mmol/l
0.20
407
2519
636
4347
2.40
34.76
7.8
6.9
13.92
12.00
umol/l
3.52
620
4165
555
3600
2.30
33.99
3.7
3.0
148.58
148.91
ug/l
0.01
521
3350
797
6201
2.77
30.38
10.9
8.5
83.07
79.05
u/l
1.30
768
5893
405
2402
2.20
29.70
5.5
4.4
7.40
7.40
ph
0.26
312
1717
63
130
5.12
29.19
2.8
2.8
4.69
4.30
e9/l
0.69
63
130
55
107
5.39
27.20
1.8
2.2
33.40
33.01
pg
0.22
55
107
168
703
2.69
26.81
4.0
4.6
0.98
0.55
%
0.72
59
208
153
613
2.78
26.55
4.8
3.6
—
—
—
0
0
172
732
2.65
26.52
3.9
4.7
0.93
0.86
%
0.12
60
226
86
245
3.76
26.30
1.8
1.4
6.22
7.79
u/l
0.76
65
197
42
65
6.71
26.18
1.0
1.2
—
—
—
0
0
536
3656
2.07
26.09
8.8
7.3
1.21
1.21
mmol/l
0.74
506
3378
71
178
4.23
25.89
3.2
2.6
19.56
16.53
%
7.48
71
173
166
702
2.65
25.88
4.0
4.8
0.11
0.11
%
0.01
54
196
68
170
4.23
24.88
3.0
2.7
58.72
58.53
%
0.04
68
170
164
707
2.60
24.52
4.2
5.2
0.08
0.12
%
0.26
53
173
150
626
2.66
23.91
4.4
4.1
1.22
1.22
mmol/l
0.28
133
541
573
4079
2.02
23.89
9.2
7.9
1.21
1.21
mmol/l
0.31
469
3529
400
2534
2.00
23.05
4.2
3.2
1384.70
1330.58
ng/l
0.12
334
2152
556
3948
1.98
22.97
22.2
14.6
1.34
1.25
inr
2.89
482
3285
520
3624
1.96
22.52
5.9
5.4
35.60
35.75
g/l
0.25
489
3401
644
4885
1.99
21.11
7.9
5.6
7.23
6.77
mmol/l
5.49
633
4680
219
1141
2.19
21.07
6.6
6.8
1.03
1.03
mmol/l
0.05
207
1058
203
1048
2.19
19.87
5.2
2.4
14.11
13.70
nmol/l
0.26
186
960
81
266
3.24
19.84
2.7
3.1
1.50
1.59
mg/l
0.44
68
243
136
605
2.46
18.78
4.4
3.5
7.41
7.42
ph
0.12
118
512
188
963
2.19
18.67
2.7
2.8
9.12
8.49
umol/l
0.19
171
863
344
2199
1.88
18.28
4.2
3.2
—
0.00
estimate
—
0
11
268
1579
1.97
18.19
3.5
3.0
526.25
547.97
mosm/kgh2o
0.90
235
1382
417
2840
1.83
18.04
4.1
3.6
34.41
35.02
u/l
0.11
402
2677
403
2722
1.83
17.87
4.5
3.4
101.44
76.11
e6/l
0.21
324
2095
304
1884
1.90
17.66
3.8
2.8
4.20
4.27
e6/l
0.05
275
1719
357
2329
1.85
17.66
4.3
3.3
0.54
0.46
e6/l
0.15
282
1714
465
3289
1.81
17.63
5.2
3.8
23.55
42.34
ng/l
4.85
371
2394
64
204
3.29
16.44
2.3
2.3
161.35
131.69
g/l
11.07
57
162
190
1025
2.07
16.32
9.5
9.8
1.88
0.90
mmol/l
1.89
158
846
719
5898
1.90
15.83
5.2
3.9
15.21
14.81
pmol/l
3.79
660
5403
100
423
2.52
15.29
2.9
2.0
32.00
37.67
nmol/l
2.48
100
409
428
3053
1.73
14.97
5.4
4.1
110.23
90.70
e6/l
0.25
337
2193
186
1034
1.99
14.57
9.8
9.8
7.41
7.41
ph
0.12
117
585
235
1431
1.85
13.93
4.4
3.5
0.82
0.82
mmol/l
0.02
224
1357
284
1835
1.78
13.83
2.0
1.7
1.03
1.24
mg/l
0.77
219
1437
29
59
5.04
13.64
1.6
1.9
18.54
19.66
nmol/l
0.25
29
53
306
2055
1.72
12.84
4.8
4.3
83.29
88.97
%
3.23
297
2021
63
231
2.85
12.74
1.9
1.7
233.24
266.41
mu/l
0.62
58
219
339
2345
1.69
12.74
4.7
3.9
0.01
0.01
estimate
0.04
150
796
314
2141
1.70
12.38
3.5
3.2
—
—
—
0
0
145
781
2.01
12.29
2.9
2.0
354.40
373.70
nmol/l
0.64
138
735
545
4283
1.64
12.24
4.6
3.8
0.02
0.02
estimate
0.05
145
806
342
2392
1.67
12.21
5.4
4.4
—
—
—
0
0
371
2653
1.65
12.13
3.4
2.8
50.50
61.38
u/l
3.86
344
2485
542
4265
1.63
12.01
4.6
3.8
8.02
5.95
estimate
0.09
168
888
536
4214
1.62
11.86
4.6
3.8
0.00
0.00
estimate
-0.00
166
873
90
413
2.30
11.46
3.5
3.7
4.66
4.56
pmol/l
0.47
80
374
329
2309
1.65
11.43
4.2
3.2
0.00
0.01
estimate
0.99
137
675
32
83
3.95
11.18
1.8
1.3
26.98
28.35
ng/l
0.09
32
83
146
814
1.94
11.16
8.7
8.4
9.76
9.97
mmol/l
0.16
141
779
125
662
2.02
11.07
2.6
2.9
64.96
66.76
g/l
1.60
112
614
56
212
2.74
10.69
3.4
3.8
9.57
1.84
index
0.88
30
125
61
243
2.61
10.54
2.3
3.9
1.78
2.54
ratio
0.72
30
141
121
646
2.00
10.46
2.3
2.5
9.70
10.92
g/l
2.91
108
599
46
163
2.91
9.93
3.6
3.3
0.78
0.88
nmol/l
0.56
39
136
64
270
2.47
9.84
2.7
4.1
48.38
46.93
mg/l
0.03
49
234
64
271
2.46
9.76
2.7
4.1
48.23
74.60
mg/l
0.59
48
233
805
7170
1.80
9.70
6.6
4.9
1.90
1.92
mu/l
0.18
739
6603
103
534
2.04
9.64
10.8
12.6
24.51
24.35
mmol/l
0.17
103
527
100
516
2.05
9.48
1.6
1.6
1.10
1.46
g/l
1.15
94
483
32
95
3.45
9.24
1.7
1.5
0.20
0.27
nmol/l
0.68
24
71
419
3233
1.53
9.17
4.4
3.7
0.20
0.02
estimate
0.53
147
725
148
884
1.80
9.04
1.7
1.5
—
—
—
0
0
133
770
1.85
8.99
11.1
11.0
—
—
—
0
0
448
3522
1.51
8.90
2.8
2.4
72.51
75.91
nmol/l
1.92
409
3167
288
2063
1.57
8.74
2.8
2.2
5.00
2.93
mg/l
7.41
248
1777
746
6565
1.63
8.71
30.2
19.9
14.42
13.62
%
20.29
741
6492
24
61
4.01
8.64
2.9
2.9
18.82
16.58
%
1.88
24
61
106
584
1.92
8.34
4.3
4.3
97.05
95.56
ng/l
0.06
85
509
349
2635
1.51
8.23
2.4
2.2
250.63
251.08
u/l
0.00
320
2505
857
7871
1.91
8.13
23.8
16.1
21.32
25.19
mg/l
3.35
776
6482
599
5056
1.50
8.09
6.1
4.5
177.43
958.59
e6/l
0.86
14
76
95
510
1.96
8.06
5.1
3.9
23.92
24.24
mmol/l
0.36
95
504
147
907
1.73
7.99
5.3
3.8
7.37
7.38
ph
0.58
85
524
142
868
1.75
7.98
4.8
3.8
1.54
1.87
mmol/l
0.46
128
738
99
544
1.92
7.85
2.3
2.6
—
—
—
0
0
239
1677
1.57
7.81
2.0
1.7
70968168.07
23016874.43
pmol/l
0.45
186
1399
42
162
2.67
7.78
1.6
1.4
—
—
—
0
0
29
92
3.22
7.58
1.3
1.3
0.21
0.18
nmol/l
0.55
21
71
26
77
3.44
7.56
3.4
4.2
18.09
12.11
index
1.06
11
54
833
7622
1.75
7.49
9.9
6.5
42.43
39.53
mmol/mol
10.88
770
7181
318
2401
1.49
7.31
7.6
6.2
—
—
—
0
0
355
2742
1.47
7.26
3.7
3.6
2.37
2.35
mmol/l
1.63
321
2498
649
5644
1.47
6.97
4.3
3.5
62.34
52.80
u/l
1.67
609
5341
868
8081
1.86
6.78
30.0
19.4
139.67
139.73
mmol/l
0.35
862
7944
38
153
2.55
6.50
1.6
1.4
160.50
162.82
au/ml
0.04
12
48
868
8100
1.83
6.46
30.5
19.6
4.00
3.99
mmol/l
0.02
862
7953
441
3616
1.41
6.25
2.1
2.1
89.95
94.99
pmol/l
1.53
245
1956
26
89
2.98
6.03
1.8
1.3
161.72
165.46
pmol/l
0.04
26
89
424
3469
1.40
6.01
2.3
2.0
1.74
1.41
mmol/l
6.82
333
2931
163
1110
1.57
5.94
1.2
1.2
—
—
—
0
0
154
1038
1.58
5.87
4.7
3.4
5.27
5.38
e9/l
0.05
131
907
375
3014
1.40
5.86
2.3
2.2
—
—
—
0
0
99
597
1.73
5.82
12.7
12.3
91.18
94.07
%
3.37
99
592
149
999
1.58
5.81
2.0
1.8
—
—
—
0
0
820
7581
1.60
5.76
5.5
4.4
1.63
1.35
mmol/l
14.18
749
7027
160
1097
1.55
5.65
1.4
1.3
581.43
415.46
titre
0.39
28
238
182
1284
1.52
5.64
1.9
1.9
—
—
—
0
0
829
7695
1.61
5.59
7.0
5.2
6.51
6.02
mmol/l
12.30
759
7094
413
3405
1.38
5.42
3.8
3.4
6.12
6.17
ph
0.48
243
1970
21
68
3.14
5.36
2.5
2.3
573.69
640.20
ml
0.51
13
40
100
629
1.66
5.04
3.5
3.1
299.16
196.43
ng/l
1.50
87
570
24
88
2.77
4.97
1.2
1.3
—
—
nmol/l
—
0
0
28
112
2.55
4.91
2.0
2.2
0.86
0.94
%
—
10
78
51
265
1.98
4.82
1.8
1.4
13.22
24.69
iu/l
3.43
46
218
17
52
3.31
4.76
2.2
2.4
499.50
495.77
min
—
10
35
205
1532
1.43
4.69
1.4
1.4
2.88
2.59
g/l
0.71
145
960
83
510
1.69
4.58
1.3
1.3
161.93
259.44
u/ml
0.93
78
478
38
181
2.15
4.53
1.7
2.0
2.67
4.37
iu/l
1.11
14
72
146
1028
1.50
4.53
1.5
1.5
—
—
—
0
0
18
59
3.09
4.53
1.1
1.1
—
—
—
0
0
56
308
1.87
4.49
2.6
2.1
22.47
20.66
s
0.71
49
277
44
223
2.02
4.47
2.4
2.4
63.99
143.22
ug/min
0.97
23
134
97
625
1.61
4.46
2.6
2.5
5.94
6.07
ph
0.71
65
423
132
918
1.51
4.35
1.8
1.7
—
—
—
0
0
32
145
2.25
4.32
1.4
1.3
63.36
60.07
mmol/l
0.19
25
123
854
8072
1.57
4.30
7.5
5.9
2.55
2.70
mmol/l
5.51
790
7541
26
108
2.45
4.25
3.2
2.5
2.96
1.30
g/24h
1.66
15
71
146
1042
1.47
4.24
1.3
1.3
—
—
—
0
0
55
307
1.84
4.23
1.2
1.2
—
—
—
0
0
148
1063
1.46
4.16
1.7
1.6
—
—
—
0
0
840
7925
1.52
4.11
6.5
5.1
1.20
1.40
mmol/l
47.81
776
7390
69
417
1.71
4.07
4.3
3.6
—
—
—
0
0
843
7964
1.52
4.04
6.6
5.2
4.29
4.58
mmol/l
14.90
784
7470
32
150
2.17
4.00
1.2
1.1
252.20
79.06
iu/ml
—
10
28
167
1238
1.42
3.96
2.1
2.2
—
—
—
0
0
177
1327
1.41
3.94
2.8
2.2
31.88
29.63
s
2.89
171
1294
91
598
1.58
3.88
13.5
12.1
1.68
1.33
%
1.97
91
593
34
166
2.09
3.85
1.3
1.2
312.38
285.08
u/ml
0.20
24
95
102
692
1.53
3.78
1.4
1.4
—
—
—
0
0
46
252
1.87
3.78
1.7
1.4
286.33
274.97
ug/g
0.12
27
160
61
368
1.70
3.64
1.8
1.9
0.58
2.25
ug/l
1.36
54
326
36
184
1.99
3.62
1.3
1.3
38.31
1181.48
e6/l
0.90
29
141
62
379
1.68
3.54
1.7
1.9
1.34
1.54
g/l
1.09
57
333
35
180
1.98
3.47
1.3
1.2
10.58
14.89
e6/l
0.20
26
131
32
160
2.03
3.43
4.2
4.4
9.55
9.87
pmol/l
0.09
32
160
43
240
1.83
3.36
1.4
1.3
—
—
—
0
0
438
3817
1.27
3.35
5.3
5.1
1.81
2.26
ug/l
1.75
398
3464
874
8373
1.55
3.34
17.5
12.2
34.19
28.29
u/l
5.15
854
8161
34
177
1.96
3.27
1.2
1.7
—
—
—
0
0
77
513
1.55
3.13
12.9
13.3
17.72
16.06
%
4.36
77
494
50
299
1.71
3.12
5.4
4.2
1.36
1.40
mmol/l
0.12
50
291
27
132
2.08
3.09
1.8
2.3
—
—
—
0
0
174
1353
1.35
3.08
4.2
3.1
2.87
1.63
e6/l
0.56
93
678
187
1472
1.34
3.05
4.2
3.0
0.99
0.92
e6/l
0.08
108
798
109
794
1.42
2.86
2.6
2.5
38.50
40.43
u/l
0.08
96
674
19
83
2.32
2.85
1.1
1.2
—
—
—
0
0
24
116
2.10
2.84
1.4
1.2
—
—
—
0
0
18
77
2.36
2.83
1.4
1.3
—
—
—
0
0
201
1617
1.31
2.81
5.2
4.0
1535.73
530.98
ng/l
0.36
157
1289
170
1336
1.33
2.80
1.9
1.7
1135.71
1179.05
nmol/l
0.25
129
1017
424
3743
1.24
2.72
3.2
2.8
—
—
estimate
—
0
0
26
133
1.98
2.67
1.2
1.1
0.57
1.72
u/ml
0.85
17
77
195
1573
1.30
2.66
3.0
3.1
2.48
2.44
mmol/l
3.69
168
1416
128
972
1.37
2.64
1.4
1.4
—
—
—
0
0
379
3315
1.24
2.62
4.3
3.2
—
—
—
0
0
30
163
1.87
2.60
3.6
3.8
11.77
27.74
mg/l
4.66
22
110
5
7
7.17
2.55
1.0
1.4
—
—
—
0
0
15
62
2.44
2.55
1.2
1.2
—
—
—
0
0
26
136
1.94
2.52
2.1
1.7
0.92
0.81
g/l
0.18
17
110
51
326
1.60
2.51
4.2
4.0
25.09
24.87
mmol/l
0.24
45
303
17
76
2.26
2.45
1.4
1.3
5.46
6.64
g/l
—
8
56
17
76
2.26
2.45
1.4
1.3
0.35
0.37
g/l
—
8
55
17
76
2.26
2.45
1.4
1.3
2.35
2.90
g/l
—
8
55
209
1720
1.28
2.44
1.3
1.3
0.84
1.82
u/ml
1.84
75
491
113
854
1.37
2.41
1.7
1.5
—
—
—
0
0
53
346
1.56
2.40
1.2
1.3
—
—
—
0
0
22
111
2.01
2.37
1.8
1.5
—
—
—
0
0
22
111
2.01
2.37
1.8
1.5
—
—
—
0
0
22
111
2.01
2.37
1.8
1.5
—
—
—
0
0
22
111
2.01
2.37
1.8
1.5
—
—
—
0
0
34
199
1.73
2.34
1.1
1.8
1.04
0.89
nmol/l
0.54
29
170
19
91
2.11
2.34
2.7
3.2
4.69
4.94
nmol/l
0.04
19
91
14
59
2.39
2.30
1.2
1.4
—
—
—
0
0
18
85
2.14
2.30
1.2
1.1
—
—
—
0
0
12
47
2.57
2.27
1.6
1.2
0.51
0.51
ratio
—
5
28
16
73
2.21
2.22
1.4
1.5
553.09
295.73
mu/l
0.42
11
56
10
35
2.88
2.21
5.5
4.3
—
—
—
0
0
66
461
1.46
2.21
1.3
1.2
147.25
133.68
u/ml
0.07
20
178
302
2619
1.22
2.19
2.7
2.5
—
—
—
0
0
83
612
1.39
2.08
1.6
1.5
—
—
—
0
0
28
161
1.76
2.07
1.3
1.2
—
—
—
0
0
10
37
2.72
2.07
6.7
7.3
3.28
25.48
ug/l
—
5
27
5
10
5.02
2.07
1.2
1.1
—
—
—
0
0
70
509
1.41
1.92
2.0
1.8
—
—
—
0
0
22
121
1.84
1.89
1.8
1.2
4.00
5.61
u/ml
0.29
12
57
14
65
2.17
1.88
1.5
1.4
—
—
—
0
0
45
301
1.52
1.88
3.1
4.0
1196.03
244.64
mg/l
0.61
31
140
11
46
2.41
1.85
4.1
2.6
—
—
—
0
0
22
122
1.82
1.85
2.0
2.8
—
—
—
0
0
265
2303
1.21
1.85
1.5
1.4
—
—
—
0
0
13
59
2.22
1.84
1.1
1.2
43.64
45.10
mg/l
—
7
49
56
394
1.45
1.84
1.3
1.2
—
—
—
0
0
8
29
2.77
1.79
1.0
1.2
—
—
—
0
0
33
208
1.61
1.79
1.2
1.3
116.43
217.59
miu/ml
1.18
12
85
65
473
1.40
1.79
1.1
1.1
—
—
—
0
0
61
443
1.40
1.71
1.5
1.7
0.19
0.33
mg/l
3.18
32
225
17
89
1.93
1.70
3.2
2.3
—
—
—
0
0
17
89
1.93
1.70
3.1
2.3
—
—
—
0
0
8
31
2.59
1.66
1.4
1.7
—
—
—
0
0
7
25
2.81
1.65
1.3
3.3
3.00
5.60
ug/l
—
7
25
14
69
2.04
1.65
1.1
1.1
—
—
—
0
0
5
14
3.58
1.61
1.8
2.1
—
—
—
0
0
5
14
3.58
1.61
1.0
1.1
—
—
—
0
0
7
26
2.70
1.58
1.6
1.3
33.71
27.65
s
—
7
26
12
57
2.12
1.55
1.0
1.2
0.02
0.38
u/ml
—
6
32
39
267
1.48
1.51
1.4
1.6
12.62
11.46
u/ml
—
5
62
16
86
1.88
1.51
1.3
1.2
—
—
—
0
0
882
8614
1.33
1.50
39.3
24.4
243.94
244.26
e9/l
0.04
877
8463
27
170
1.61
1.50
1.8
1.5
—
—
—
0
0
14
72
1.96
1.49
2.1
1.4
26.13
25.35
%
—
7
48
882
8618
1.33
1.46
39.4
24.4
7.74
6.76
e9/l
24.94
875
8441
882
8618
1.33
1.46
39.3
24.3
5.27
4.56
e12/l
137.80
874
8442
53
388
1.39
1.45
4.0
3.5
1.02
1.02
ratio
0.00
39
365
14
73
1.93
1.44
3.3
2.8
1139.93
1285.74
mg
0.14
14
73
6
22
2.74
1.43
1.7
1.4
33.83
24.36
%
—
6
22
6
22
2.74
1.43
1.2
1.2
46.00
66.41
nmol/24h
—
6
22
24
149
1.63
1.42
1.0
1.1
—
—
—
0
0
7
29
2.42
1.39
1.0
1.1
—
—
—
0
0
13
67
1.95
1.38
1.3
1.5
75.92
82.10
umol/l
0.45
13
67
264
2349
1.17
1.38
1.8
1.7
17.91
19.75
nmol/l
1.48
226
1978
259
2303
1.17
1.37
3.3
3.0
0.72
0.73
ug/l
0.17
165
1388
105
856
1.25
1.36
3.9
4.7
4.42
23.98
ug/l
1.35
95
721
93
748
1.27
1.35
2.7
2.3
10.39
7.93
ug/l
0.28
78
672
10
47
2.14
1.34
1.0
1.0
—
—
—
0
0
12
61
1.98
1.33
1.6
2.0
41.52
41.14
%
0.03
12
61
25
160
1.58
1.32
1.1
1.1
—
—
—
0
0
15
83
1.82
1.32
1.1
1.4
10.60
26.24
u/l
2.61
15
67
9
44
2.06
1.27
1.1
1.1
164.11
141.03
nmol/l
—
9
44
44
321
1.39
1.25
1.6
1.9
7.01
6.66
iu/ml
—
7
80
95
774
1.25
1.25
2.3
2.2
0.00
0.02
estimate
0.50
25
160
117
978
1.22
1.22
2.4
2.6
99.76
125.11
ug/g
0.88
99
800
21
321
0.65
1.18
1.0
1.1
1.34
1.49
g/l
1.39
21
321
7
30
2.34
1.12
1.0
1.0
—
—
—
0
0
7
31
2.27
1.10
3.7
3.1
0.60
0.60
mmol/l
—
7
31
14
81
1.74
1.09
1.9
2.4
—
—
—
0
0
15
89
1.70
1.08
1.3
1.7
—
—
—
0
0
23
336
0.68
1.06
1.3
1.2
0.87
0.91
g/l
0.37
23
336
15
90
1.68
1.04
2.1
1.6
61.87
62.47
%
—
8
60
5
22
2.28
1.03
20.6
7.5
7.20
5.25
kpa
—
5
22
18
114
1.59
1.03
1.3
1.2
—
—
—
0
0
47
361
1.32
1.01
3.1
2.7
—
—
—
0
0
19
283
0.66
0.97
1.1
1.1
—
—
—
0
0
7
36
1.95
0.97
1.6
1.6
—
3232.00
—
0
5
37
276
1.35
0.97
1.7
2.6
—
—
—
0
0
9
52
1.74
0.92
2.7
1.8
89.33
106.83
ng/l
—
9
52
15
94
1.61
0.91
1.3
1.4
—
—
—
0
0
17
111
1.54
0.88
1.0
1.1
0.66
1.29
u/ml
—
10
63
153
1354
1.15
0.88
1.3
1.3
6.46
10.40
u/ml
0.46
66
540
15
95
1.59
0.87
2.2
1.9
11.85
10.61
%
0.37
15
95
45
352
1.29
0.87
2.8
1.8
—
—
—
0
0
6
31
1.94
0.84
1.0
1.0
—
—
—
0
0
55
676
0.80
0.84
1.7
1.8
3.24
3.50
mmol/l
0.82
39
499
12
73
1.65
0.82
1.1
1.2
—
—
—
0
0
38
294
1.30
0.81
1.7
2.5
—
—
—
0
0
63
759
0.82
0.81
1.7
1.4
—
—
—
0
0
0
24
0.00
0.79
0.0
2.0
—
10.03
—
0
18
0
25
0.00
0.79
0.0
2.2
—
4838.38
—
0
13
38
299
1.28
0.73
1.7
2.4
—
—
—
0
0
38
299
1.28
0.73
1.7
2.5
—
—
—
0
0
7
39
1.80
0.72
1.4
1.7
—
—
—
0
0
10
60
1.67
0.72
1.8
1.1
78.00
102.52
pmol/l
—
10
60
12
76
1.59
0.72
1.4
1.1
—
—
—
0
0
7
41
1.71
0.70
1.0
1.3
138.71
184.82
mmol/24h
—
7
41
7
42
1.67
0.68
1.1
1.1
179.34
252.46
iu/ml
—
7
42
26
196
1.34
0.68
1.2
1.2
—
—
—
0
0
17
119
1.44
0.67
1.0
1.1
3.72
6.25
u/ml
—
6
65
37
296
1.26
0.64
1.7
2.3
—
—
—
0
0
66
563
1.19
0.63
2.4
2.5
25.18
19.39
au/ml
—
5
59
28
217
1.30
0.62
1.3
1.2
—
—
—
0
0
162
1477
1.12
0.62
1.3
1.3
17.34
30.22
iu/ml
3.68
49
440
5
30
1.67
0.61
1.2
1.4
0.00
1.38
%
—
5
25
0
20
0.00
0.60
0.0
1.5
—
28.22
—
0
15
0
21
0.00
0.60
0.0
5.5
—
8.62
—
0
21
0
21
0.00
0.60
0.0
2.8
—
43.67
—
0
21
206
1907
1.10
0.59
4.2
3.9
1.02
1.02
kg/l
0.12
149
1285
0
22
0.00
0.59
0.0
1.2
—
137.81
—
0
16
16
114
1.41
0.59
1.0
1.1
0.13
1.08
u/ml
—
5
51
42
346
1.22
0.58
2.4
3.9
122.80
4308.26
u/ml
0.82
35
295
13
89
1.47
0.58
1.2
1.1
—
—
—
0
0
34
419
0.80
0.58
2.1
2.4
0.00
1.95
estimate
0.51
13
130
36
292
1.24
0.57
2.9
2.7
22.23
81.32
u/ml
0.83
36
279
9
61
1.48
0.53
1.3
1.1
—
—
—
0
0
6
39
1.54
0.53
1.0
1.0
1796.83
1516.18
miu/ml
—
6
39
17
127
1.34
0.50
2.3
3.2
—
—
—
0
0
14
101
1.39
0.49
1.0
1.1
2.87
2.18
u/ml
—
8
57
14
102
1.38
0.47
3.9
2.6
—
—
—
0
0
27
221
1.23
0.42
1.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
5
34
1.47
0.40
2.2
1.3
0.60
0.09
estimate
—
5
34
5
35
1.43
0.39
1.0
1.3
116.60
111.65
nmol/l
—
5
26
9
66
1.37
0.38
1.3
1.1
—
—
—
0
0
9
69
1.31
0.37
1.0
1.0
—
—
—
0
0
27
228
1.19
0.33
1.2
1.2
—
—
—
0
0
12
92
1.31
0.32
1.0
1.1
0.51
2.31
u/ml
—
6
45
12
93
1.29
0.30
1.3
1.3
30960.00
17611.22
e6/l
—
5
49
13
103
1.27
0.28
1.4
1.3
3133.29
1760.53
e6/l
—
7
64
17
140
1.22
0.27
1.0
1.1
13.92
20.83
au/ml
—
5
40
11
87
1.27
0.24
1.4
1.4
—
—
—
0
0
5
42
1.19
0.21
1.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
17.31
—
0
12
0
13
0.00
0.21
0.0
1.0
—
18.67
—
0
6
27
240
1.13
0.20
1.4
1.6
14952.06
16777.18
e6/l
0.14
17
168
0
14
0.00
0.20
0.0
1.9
—
0.25
—
0
5
53
567
0.93
0.17
1.1
1.2
—
—
—
0
0
17
148
1.15
0.17
1.2
1.1
—
—
—
0
0
17
148
1.15
0.17
1.2
1.1
—
—
—
0
0
5
70
0.71
0.16
1.2
1.2
—
—
—
0
0
13
111
1.17
0.16
1.2
1.2
—
—
—
0
0
48
513
0.93
0.15
1.2
1.3
—
—
—
0
0
7
86
0.81
0.14
2.4
2.1
—
—
—
0
0
12
103
1.17
0.13
1.2
1.1
—
—
—
0
0
20
180
1.11
0.13
11.3
9.5
11.75
11.50
mmol/l
0.10
20
163
20
180
1.11
0.13
11.3
9.5
104.70
105.40
mmol/l
0.31
20
163
10
87
1.15
0.09
1.6
1.2
—
—
—
0
0
10
87
1.15
0.09
1.0
1.0
0.00
0.29
u/ml
—
5
39
5
48
1.04
0.09
1.2
1.5
—
—
—
0
0
28
264
1.06
0.07
1.3
1.6
—
—
—
0
0
9
87
1.03
0.07
1.0
1.2
—
—
—
0
0
12
109
1.10
0.06
1.2
1.1
17.34
2.70
eliau/ml
—
5
42
39
375
1.04
0.06
2.3
2.4
—
—
—
0
0
20
189
1.06
0.04
5.8
4.6
—
—
—
0
0
77
754
1.02
0.04
4.8
4.2
7.37
7.35
ph
0.85
59
551
26
251
1.04
0.02
19.6
10.5
—
—
—
0
0
35
341
1.03
0.02
1.5
1.6
—
—
—
0
0
15
149
1.01
0.00
1.4
1.4
—
—
—
0
0
7
74
0.95
0.00
1.1
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
245.82
—
0
6
9
95
0.95
-0.00
1.1
1.4
7.29
6.24
mmol/l
—
9
90
8
88
0.91
-0.00
1.8
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.06
—
0
6
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
402.00
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
0.16
—
0
5
0
5
0.00
-0.00
0.0
2.6
—
194.80
—
0
5
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint D3_SCNDPOLYCYTHAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_SCNDPOLYCYTHAEMIA 2.337 [1.94, 2.81] < 0.001
Birth year 0.998 [0.99, 1.01] 0.556

During the follow-up period (1.1.1998 — 31.12.2019), 330 out of 1298 females with D3_SCNDPOLYCYTHAEMIA died.

Males

Parameter HR [95% CI] p-value
D3_SCNDPOLYCYTHAEMIA 1.929 [1.65, 2.25] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 574 out of 2522 males with D3_SCNDPOLYCYTHAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_SCNDPOLYCYTHAEMIA.

N-year risk Females Males
1 0.314% 0.369%
5 1.509% 2.132%
10 3.477% 5.162%
15 6.641% 10.023%
20 12.368% 16.089%

Relationships between endpoints

↥

Index endpoint: D3_SCNDPOLYCYTHAEMIA – Secondary polycythaemia

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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